glycine

Summary

Summary: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.

Top Publications

  1. doi Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
    Wen cai Zhang
    Stem Cell and Developmental Biology, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672
    Cell 148:259-72. 2012
  2. pmc Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
    Mohit Jain
    Broad Institute, Cambridge, MA 02142, USA
    Science 336:1040-4. 2012
  3. pmc Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells
    P M Tedeschi
    1 Department of Medicine, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA 2 Department of Pharmacology, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
    Cell Death Dis 4:e877. 2013
  4. ncbi The inferior colliculus of the rat: quantitative immunocytochemical study of GABA and glycine
    M Merchan
    Laboratory for the Neurobiology of Hearing, Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, Salamanca, Spain
    Neuroscience 136:907-25. 2005
  5. pmc Serine, glycine and one-carbon units: cancer metabolism in full circle
    Jason W Locasale
    Field of Biochemistry and Molecular Cell Biology, Cornell University, Ithaca New York 14850, USA
    Nat Rev Cancer 13:572-83. 2013
  6. pmc Bile salts and glycine as cogerminants for Clostridium difficile spores
    Joseph A Sorg
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Bacteriol 190:2505-12. 2008
  7. pmc Reciprocal regulation of glycine-rich RNA-binding proteins via an interlocked feedback loop coupling alternative splicing to nonsense-mediated decay in Arabidopsis
    Jan C Schöning
    Molecular Cell Physiology, Bielefeld University, Bielefeld, Germany
    Nucleic Acids Res 36:6977-87. 2008
  8. pmc A bimodal distribution of two distinct categories of intrinsically disordered structures with separate functions in FG nucleoporins
    Justin Yamada
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    Mol Cell Proteomics 9:2205-24. 2010
  9. ncbi A shared vesicular carrier allows synaptic corelease of GABA and glycine
    Sonja M Wojcik
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Neuron 50:575-87. 2006
  10. ncbi Colocalization of GABA and glycine in the ventral nucleus of the lateral lemniscus in rat: an in situ hybridization and semiquantitative immunocytochemical study
    R Riquelme
    Laboratory for the Neurobiology of Hearing, Department of Cell Biology and Pathology, University of Salamanca, , E-37007 Salamanca, Spain
    J Comp Neurol 432:409-24. 2001

Research Grants

Detail Information

Publications439 found, 100 shown here

  1. doi Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
    Wen cai Zhang
    Stem Cell and Developmental Biology, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672
    Cell 148:259-72. 2012
    ..Here we show that the metabolic enzyme glycine decarboxylase (GLDC) is critical for TICs in non-small cell lung cancer (NSCLC)...
  2. pmc Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
    Mohit Jain
    Broad Institute, Cambridge, MA 02142, USA
    Science 336:1040-4. 2012
    ..This analysis identified glycine consumption and expression of the mitochondrial glycine biosynthetic pathway as strongly correlated with rates of ..
  3. pmc Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells
    P M Tedeschi
    1 Department of Medicine, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA 2 Department of Pharmacology, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
    Cell Death Dis 4:e877. 2013
    ..The pathway is composed by reactions from serine synthesis, one-carbon (folate) metabolism and the glycine cleavage system (SOG pathway)...
  4. ncbi The inferior colliculus of the rat: quantitative immunocytochemical study of GABA and glycine
    M Merchan
    Laboratory for the Neurobiology of Hearing, Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, Salamanca, Spain
    Neuroscience 136:907-25. 2005
    Both GABA and glycine (Gly) containing neurons send inhibitory projections to the inferior colliculus (IC), whereas inhibitory neurons within the IC are primarily GABAergic...
  5. pmc Serine, glycine and one-carbon units: cancer metabolism in full circle
    Jason W Locasale
    Field of Biochemistry and Molecular Cell Biology, Cornell University, Ithaca New York 14850, USA
    Nat Rev Cancer 13:572-83. 2013
    ..Given the wealth of clinically available agents that target one-carbon metabolism, these new findings could present opportunities for translation into precision cancer medicine. ..
  6. pmc Bile salts and glycine as cogerminants for Clostridium difficile spores
    Joseph A Sorg
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Bacteriol 190:2505-12. 2008
    ..difficile spores to bile. We found that cholate derivatives and the amino acid glycine act as cogerminants...
  7. pmc Reciprocal regulation of glycine-rich RNA-binding proteins via an interlocked feedback loop coupling alternative splicing to nonsense-mediated decay in Arabidopsis
    Jan C Schöning
    Molecular Cell Physiology, Bielefeld University, Bielefeld, Germany
    Nucleic Acids Res 36:6977-87. 2008
    ..A high degree of evolutionary sequence conservation in the introns retained in as_AtGRP8 or as_AtGRP7 points to an important function of these sequences...
  8. pmc A bimodal distribution of two distinct categories of intrinsically disordered structures with separate functions in FG nucleoporins
    Justin Yamada
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    Mol Cell Proteomics 9:2205-24. 2010
    ..gate is formed by nucleoporins containing large intrinsically disordered domains with multiple phenylalanine-glycine repeats (FG domains)...
  9. ncbi A shared vesicular carrier allows synaptic corelease of GABA and glycine
    Sonja M Wojcik
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Neuron 50:575-87. 2006
    ..both GABAergic and glycinergic neurons, indicating that glycinergic neurons do not express a separate vesicular glycine transporter...
  10. ncbi Colocalization of GABA and glycine in the ventral nucleus of the lateral lemniscus in rat: an in situ hybridization and semiquantitative immunocytochemical study
    R Riquelme
    Laboratory for the Neurobiology of Hearing, Department of Cell Biology and Pathology, University of Salamanca, , E-37007 Salamanca, Spain
    J Comp Neurol 432:409-24. 2001
    ..immunocytochemistry in consecutive semithin sections, the expression of gamma-aminobutyric acid (GABA) and glycine in cell bodies and axosomatic puncta of the rat ventral nucleus of the lateral lemniscus (VNLL), a prominent ..
  11. pmc Lack of sugar discrimination by human Pol mu requires a single glycine residue
    Jose F Ruiz
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Campus de la Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Nucleic Acids Res 31:4441-9. 2003
    ..The unusual capacity to insert both rNTPs and dNTPs will be discussed in the context of the predicted roles of Pol mu in DNA repair...
  12. pmc N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
    Douglas McHugh
    The Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    BMC Neurosci 11:44. 2010
    ..N-arachidonoyl glycine (NAGly) is an endogenous metabolite of the endocannabinoid anandamide and acts as an efficacious agonist at GPR18...
  13. ncbi Structure validation by Calpha geometry: phi,psi and Cbeta deviation
    Simon C Lovell
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    Proteins 50:437-50. 2003
    ..To run our geometrical evaluations on a user-uploaded file, see MOLPROBITY (http://kinemage.biochem.duke.edu) or RAMPAGE (http://www-cryst.bioc.cam.ac.uk/rampage)...
  14. doi Glyphosate: a once-in-a-century herbicide
    Stephen O Duke
    USDA ARS, Natural Products Utilization Research Unit, National Center for Natural Products Research, PO Box 8048, University, MS 38677, USA
    Pest Manag Sci 64:319-25. 2008
    Since its commercial introduction in 1974, glyphosate [N-(phosphonomethyl)glycine] has become the dominant herbicide worldwide. There are several reasons for its success...
  15. pmc Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis
    G Scott Pesiridis
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 18:R156-62. 2009
    ..TDP-43 possesses two RNA binding domains (RBD) and a glycine-rich C terminus classifying it with other heterogeneous nuclear ribonucleoproteins known as 2XRBD-Gly proteins...
  16. pmc Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy
    Chatchai Muanprasat
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0521, USA
    J Gen Physiol 124:125-37. 2004
    ..small molecules revealed four novel chemical classes of CFTR inhibitors with Ki < 10 microM, one of which (glycine hydrazides) had many active structural analogues...
  17. pmc UGA is an additional glycine codon in uncultured SR1 bacteria from the human microbiota
    James H Campbell
    Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Proc Natl Acad Sci U S A 110:5540-5. 2013
    ..In-frame TGA (opal) codons are found in most genes (85%), often at loci normally encoding conserved glycine residues...
  18. doi Glycine regulates the production of pro-inflammatory cytokines in lean and monosodium glutamate-obese mice
    F J Alarcon-Aguilar
    Laboratorio de Farmacologia, Departamento de Ciencias de la Salud, Div de Ciencias Biologicas y de la Salud, Universidad Autonoma Metropolitana Unidad Iztapalapa, Mexico, D F Mexico
    Eur J Pharmacol 599:152-8. 2008
    ..In the present study, we investigated whether glycine, an amino acid that represses the expression in vitro of pro-inflammatory cytokines in Kupffer and 3T3-L1 cells, ..
  19. pmc Rapid, activity-independent turnover of vesicular transmitter content at a mixed glycine/GABA synapse
    Pierre F Apostolides
    Neuroscience Graduate Program, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 33:4768-81. 2013
    ..We addressed these issues by recording from synaptically coupled pairs of glycine/GABA coreleasing interneurons (cartwheel cells) of the mouse dorsal cochlear nucleus...
  20. doi Detection and diversity of a putative novel heterogeneous polymorphic proline-glycine repeat (Pgr) protein in the footrot pathogen Dichelobacter nodosus
    Leo A Calvo-Bado
    Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    Vet Microbiol 147:358-66. 2011
    ..The aim of this study was to determine the diversity of the pgr gene, which encodes a putative proline-glycine repeat protein (Pgr). The pgr gene was present in all 100 isolates of D...
  21. ncbi A glycine-dependent riboswitch that uses cooperative binding to control gene expression
    Maumita Mandal
    Department of Molecular, Cellular, and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520 8103, USA
    Science 306:275-9. 2004
    We identified a previously unknown riboswitch class in bacteria that is selectively triggered by glycine. A representative of these glycine-sensing RNAs from Bacillus subtilis operates as a rare genetic on switch for the gcvT operon, ..
  22. pmc Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation
    Johannes A Mayr
    Department of Pediatrics, Paracelsus Medical University Salzburg, Salzburg 5020, Austria
    Am J Hum Genet 89:792-7. 2011
    ..in the oxidative decarboxylation of pyruvate, α-ketoglutarate, and branched chain amino acids and in the glycine cleavage...
  23. doi Mechanism of resistance of evolved glyphosate-resistant Palmer amaranth (Amaranthus palmeri)
    Todd A Gaines
    Department of Bioagricultural Sciences and Pest Management, Colorado State University, 1177 Campus Delivery, Fort Collins, Colorado 80523, USA
    J Agric Food Chem 59:5886-9. 2011
    ..Questions remain related to how the EPSPS amplification initially occurred and the occurrence of this mechanism in other Palmer amaranth populations and other glyphosate-resistant species...
  24. ncbi Distribution of glutamate-, glycine- and GABA-immunoreactive nerve terminals on dendrites in the cat spinal motor nucleus
    G Ornung
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Exp Brain Res 118:517-32. 1998
    ..In this study we examined the distribution of glutamate-, GABA- and glycine-like immunoreactivity in boutons apposing dendrites in the L7 spinal cord motor nucleus, by use of postembedding ..
  25. ncbi Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition
    C A Hübner
    Zentrum fur Molekulare Neurobiologie Hamburg, ZMNH, Universitat Hamburg, Martinistr 52, D 20246, Hamburg, Germany
    Neuron 30:515-24. 2001
    Synaptic inhibition by GABA(A) and glycine receptors, which are ligand-gated anion channels, depends on the electrochemical potential for chloride...
  26. ncbi Plasma glutamate and glycine levels in patients with amyotrophic lateral sclerosis
    Elisabeth Andreadou
    Department of Neurology, Athens National University, Aeginition Hospital, Athens, Greece
    In Vivo 22:137-41. 2008
    ..b>Glycine (Gly), the main inhibitory neurotransmitter, has been shown to potentiate excitatory transmission...
  27. doi Structures of the glycine-rich diastereomeric peptides bombinin H2 and H4
    Klaus Zangger
    Institute of Chemistry, University of Graz, Heinrichstrasse 28, A 8010 Graz, Austria
    Toxicon 52:246-54. 2008
    ..These peptides are rich in glycine (25%), which may allow structural polymorphism...
  28. doi Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant
    Masanori Tachikawa
    Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    J Neurochem 107:768-78. 2008
    ..However, in the presence of endogenous creatine in the CSF, CRT may make only a limited contribution to the GAA efflux transport at the BCSFB...
  29. pmc Long-term potentiation depends on release of D-serine from astrocytes
    Christian Henneberger
    UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Nature 463:232-6. 2010
    ..This LTP blockade can be reversed by exogenous D-serine or glycine, whereas depletion of D-serine or disruption of exocytosis in an individual astrocyte blocks local LTP...
  30. ncbi Heteromeric NMDA receptors: molecular and functional distinction of subtypes
    H Monyer
    Center for Molecular Biology, University of Heidelberg, Germany
    Science 256:1217-21. 1992
    ..possesses high calcium permeability and unique voltage-dependent sensitivity to magnesium and is modulated by glycine. Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits ..
  31. pmc Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine
    Yunlei Yang
    Institute of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 100:15194-9. 2003
    ..Supplement of D-serine, an agonist for the glycine-binding site of N-methyl-D-aspartate (NMDA) receptors, enhanced NMDA receptor activation and enabled LTP ..
  32. pmc Genome analysis: RNA recognition motif (RRM) and K homology (KH) domain RNA-binding proteins from the flowering plant Arabidopsis thaliana
    Zdravko J Lorkovic
    Institute of Medical Biochemistry, Vienna University, Dr Bohrgasse 9 3, 1030 Vienna, Austria
    Nucleic Acids Res 30:623-35. 2002
    ..This survey provides a first systematic analysis of plant RNA-binding proteins, which may serve as a basis for functional characterisation of this important protein group in plants...
  33. ncbi Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity
    Theresa M Ballard
    Preclinical CNS Research, F Hoffmann La Roche Limited, CH 4070 Basel, Switzerland
    J Neurosci 22:6713-23. 2002
    ..We previously have described two mouse lines carrying point mutations in the NMDA receptor glycine binding site, Grin1(D481N) and Grin1(K483Q), which exhibit 5- and 86-fold reductions in receptor glycine affinity,..
  34. ncbi The functional role of GABA and glycine in monaural and binaural processing in the inferior colliculus of horseshoe bats
    M Vater
    , FRG
    J Comp Physiol A 171:541-53. 1992
    The functional role of GABA and glycine in monaural and binaural signal analysis was studied in single unit recordings from the central nucleus of the inferior colliculus (IC) of horseshoe bats (Rhinolophus rouxi) employing ..
  35. pmc Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine
    Rajagopal V Sekhar
    Translational Metabolism Unit, Baylor College of Medicine, Houston, Texas, USA
    Diabetes Care 34:162-7. 2011
    ..GSH in adult patients with uncontrolled type 2 diabetes is attributed to decreased synthesis and measured the effect of dietary supplementation with its precursors cysteine and glycine on GSH synthesis rate and oxidative stress.
  36. pmc A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth
    H Nishiyama
    Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan
    J Cell Biol 137:899-908. 1997
    ..The cirp cDNA encoded an 18-kD protein consisting of an amino-terminal RNAbinding domain and a carboxyl-terminal glycine-rich domain and exhibited structural similarity to a class of stress-induced RNA-binding proteins found in plants...
  37. pmc Structural transitions and thermodynamics of a glycine-dependent riboswitch from Vibrio cholerae
    Jan Lipfert
    Department of Physics, Stanford University, Stanford, CA 94305, USA
    J Mol Biol 365:1393-406. 2007
    ..Recently, Breaker and coworkers reported a tandem aptamer riboswitch (VCI-II) that binds glycine cooperatively...
  38. pmc Novel functions of prototype foamy virus Gag glycine- arginine-rich boxes in reverse transcription and particle morphogenesis
    Erik Müllers
    Institut fur Virologie, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr 74, 01307 Dresden, Germany
    J Virol 85:1452-63. 2011
    ..Instead, it contains three glycine-arginine-rich boxes (GR boxes) in its C terminus that putatively represent a functional equivalent...
  39. ncbi Elimination and strengthening of glycinergic/GABAergic connections during tonotopic map formation
    Gunsoo Kim
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 6:282-90. 2003
    ..These results provide new insights into the mechanisms by which precisely organized inhibitory circuits are established during development...
  40. pmc Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants
    Pascal Maser
    Division of Biology, Cell and Developmental Biology Section, and Center for Molecular Genetics, University of California at San Diego, La Jolla, CA 92093 0116, USA
    Proc Natl Acad Sci U S A 99:6428-33. 2002
    ..A single-point mutation, Ser-68 to glycine, was sufficient to restore K(+) permeability to AtHKT1...
  41. ncbi Proline-induced distortions of transmembrane helices
    Frank S Cordes
    Laboratory of Molecular Biophysics, The Rex Richards Building, Department of Biochemistry, University of Oxford, South Parks Road, UK
    J Mol Biol 323:951-60. 2002
    ..A superposition of proline-containing TM helices structures shows that the distortion induced is anisotropic and favours certain relative orientations (defined by helix kink and swivel angles) of the two helix segments...
  42. pmc Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors
    Alexei Vazquez
    Center for Systems Biology and Department of Radiation Oncology, Graduate School of Biomedical Sciences, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
    Cancer Res 73:478-82. 2013
    ..Recent studies have shown that the mitochondrial enzymes in the cellular metabolism of serine, folate, and glycine are overexpressed in a subset of human cancers and that their expression is required for tumor maintenance...
  43. pmc High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors
    Valeria Righi
    NMR Surgical Laboratory, Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Oncol 36:301-6. 2010
    The non-essential amino acid neurotransmitter glycine (Gly) may serve as a biomarker for brain tumors...
  44. doi Glycine-mediated changes of onset reliability at a mammalian central synapse
    C Kopp-Scheinpflug
    Institute of Biology II, University of Leipzig, Talstrasse 33, 04103 Leipzig, Germany
    Neuroscience 157:432-45. 2008
    b>Glycine is an inhibitory neurotransmitter activating a chloride conductance in the mammalian CNS...
  45. doi Glycine regulates inflammatory markers modifying the energetic balance through PPAR and UCP-2
    J C Almanza-Perez
    Posgrado en Biologia Experimental, Division de Ciencias Biologicas y de Salud, Universidad Autonoma Metropolitana Unidad Iztapalapa, Apdo Postal 55 535, CP 09340, DF Mexico, Mexico
    Biomed Pharmacother 64:534-40. 2010
    ..and participates in a broad spectrum of processes. Recently, glycine has been reported to have anti-inflammatory properties which reduce TNF-α and IL-6 levels and increase ..
  46. pmc Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes
    Weijia Xie
    Genetics of Complex Traits, Peninsula School of Medicine, University of Exeter, Exeter, UK
    Diabetes 62:2141-50. 2013
    ..The top-ranking metabolites were in the glutathione and glycine biosynthesis pathways...
  47. doi Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor- independent mechanical allodynia
    Loïs S Miraucourt
    INSERM, U929, F 63000 Clermont Ferrand, France
    J Neurosci 29:2519-27. 2009
    ..provided a novel perspective on the mechanisms of this symptom by showing that a simple switch in trigeminal glycine synaptic inhibition can turn touch into pain by unmasking innocuous input to superficial dorsal horn nociceptive ..
  48. pmc Subunit-selective allosteric inhibition of glycine binding to NMDA receptors
    Kasper B Hansen
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia 30322, USA
    J Neurosci 32:6197-208. 2012
    ..NMDA receptors are activated upon simultaneous binding of coagonists glycine and glutamate to the GluN1 and GluN2 subunits, respectively...
  49. ncbi Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine
    Alan A Jackson
    Institute of Human Nutrition, Fetal Origins of Adult Disease Research Division, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Clin Sci (Lond) 103:633-9. 2002
    ..On a low-protein diet, the endogenous formation of the amino acid glycine is thought to become constrained...
  50. doi Low homoarginine concentration is a novel risk factor for heart disease
    Stefan Pilz
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
    Heart 97:1222-7. 2011
    ..Homoarginine is an amino acid which may play a role in nitric oxide and energy metabolism. Low homoarginine concentrations have previously been linked to increased mortality, but the underlying mechanisms remain unknown...
  51. ncbi Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme
    Thomas Dierks
    Biochemie II, Universitat Gottingen, Germany
    Cell 113:435-44. 2003
    ..The gene encoding FGE is highly conserved among pro- and eukaryotes and has a paralog of unknown function in vertebrates. FGE is localized in the endoplasmic reticulum and is predicted to have a tripartite domain structure...
  52. pmc Chemical basis of glycine riboswitch cooperativity
    Miyun Kwon
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    RNA 14:25-34. 2008
    The glycine binding riboswitch forms a unique tandem aptamer structure that binds glycine cooperatively...
  53. doi Physical and chemical factors influencing the germination of Clostridium difficile spores
    L J Wheeldon
    School of Life and Health Sciences, Biomedical Sciences, Aston University, Aston Triangle, Birmingham, UK
    J Appl Microbiol 105:2223-30. 2008
    ..To investigate the influence of chemical and physical factors on the rate and extent of germination of Clostridium difficile spores...
  54. pmc Activity of the small modified amino acid alpha-hydroxy glycineamide on in vitro and in vivo human immunodeficiency virus type 1 capsid assembly and infectivity
    Samir Abdurahman
    Division of Clinical Microbiology, Karolinska Institutet, F68 Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Antimicrob Agents Chemother 52:3737-44. 2008
    ..As an antiviral compound, alpha-HGA has an unusually simple structure, a pronounced antiviral specificity, and a novel mechanism of antiviral action. As such, it might prove to be a lead compound for a new class of anti-HIV substances...
  55. pmc The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation
    Jane Ding
    Cancer Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA
    Cell Metab 18:896-907. 2013
    Increased activation of the serine-glycine biosynthetic pathway is an integral part of cancer metabolism that drives macromolecule synthesis needed for cell proliferation. Whether this pathway is under epigenetic control is unknown...
  56. doi Glycine receptors influence radial migration in the embryonic mouse neocortex
    Birgit Nimmervoll
    Institute of Physiology and Pathophysiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Neuroreport 22:509-13. 2011
    To investigate whether glycine receptors influence radial migration in the neocortex, we analyzed the effect of glycine and the glycinergic antagonist strychnine, on the distribution of 5-bromo-2'deoxyuridine-labeled neurons in ..
  57. ncbi Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate
    L M Stead
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3X9
    Am J Physiol Endocrinol Metab 281:E1095-100. 2001
    ..The activity of kidney L-arginine:glycine amidinotransferase, the enzyme catalyzing the synthesis of guanidinoacetate, was significantly decreased in both ..
  58. ncbi A family with Stickler syndrome type 2 has a mutation in the COL11A1 gene resulting in the substitution of glycine 97 by valine in alpha 1 (XI) collagen
    A J Richards
    Department of Pathology, University of Cambridge, UK
    Hum Mol Genet 5:1339-43. 1996
    ..including vitreous and retinal abnormalities is linked to the COL11A1 gene and characterise the mutation as a Glycine to Valine substitution at position 97 of the triple helical domain caused by a single base G-->T mutation...
  59. doi Structural characterization of nanoscale meshworks within a nucleoporin FG hydrogel
    Marcel Petri
    Research Group of Structural Dynamics of Bio chemical Systems, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Biomacromolecules 13:1882-9. 2012
    ..It consists of phenylalanine-glycine (FG) repeat domains apparently organized as an FG hydrogel...
  60. doi Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells
    Chengtie Wu
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
    Acta Biomater 9:9159-68. 2013
    ..Dimethyloxallyl glycine (DMOG) is a cell-permeable, competitive inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH), which ..
  61. ncbi Differential distribution of synaptic endings containing glutamate, glycine, and GABA in the rat dorsal cochlear nucleus
    Maria E Rubio
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269 4156, USA
    J Comp Neurol 477:253-72. 2004
    ..Only one category of synaptic ending was immunoreactive for glutamate and three for glycine and/or gamma-aminobutyric-acid (GABA). Among those, nine subtypes of synaptic endings were identified...
  62. doi Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients
    Mineji Hayakawa
    Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan
    Shock 33:14-8. 2010
    ..The length of ICU stay of the sivelestat group was significantly shorter than that of the control group. In addition, sivelestat administration was found to be an independent predictor of survival of those patients...
  63. ncbi Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation
    Glen B Banks
    School of Biomedical Sciences, University of Queensland, St Lucia, 4072 Queensland, Australia
    J Neurosci 25:1249-59. 2005
    ..In gephyrin-deficient mice that lack all postsynaptic glycine receptor and some GABA(A) receptor clusters, there was increased spontaneous respiratory motor activity, reduced ..
  64. ncbi The cell attachment site on foot-and-mouth disease virus includes the amino acid sequence RGD (arginine-glycine-aspartic acid)
    G Fox
    Wellcome Biotechnology Ltd, Pirbright, Surrey, U K
    J Gen Virol 70:625-37. 1989
    The amino acid sequence RGD (arginine-glycine-aspartic acid) is highly conserved in the VP1 protein of foot-and-mouth disease virus (FMDV), despite being situated in the immunodominant hypervariable region between amino acids 135 and 160...
  65. pmc Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells
    Douglas McHugh
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Br J Pharmacol 165:2414-24. 2012
    ..The endocannabinoid system regulates cellular migration. Given the growing involvement of the endocannabinoids in reproduction, we investigated the role of the endocannabinoid system in migration of endometrial cells...
  66. ncbi Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis
    Kentaro Iwata
    Division of Health Risk Management, Research Center for Urban Safety and Security, Kobe University, Kobe, Japan
    Intern Med 49:2423-32. 2010
    ..Sivelestat is neutrophil elastase inhibitor, which is widely used in Japan for the treatment of acute lung injury. However, the clinical efficacy of the medication has not been convincingly demonstrated...
  67. ncbi Proline and glycine control protein self-organization into elastomeric or amyloid fibrils
    Sarah Rauscher
    Molecular Structure and Function Programme, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Structure 14:1667-76. 2006
    ..those of elastin, amyloids, spider silks, wheat gluten, and insect resilin, reveals a threshold in proline and glycine composition above which amyloid formation is impeded and elastomeric properties become apparent...
  68. pmc Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening
    Iehab Talukder
    Graduate Program in Neuroscience, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Gen Physiol 138:179-94. 2011
    ..NMDA receptors are obligate heterotetramers typically composed of glycine-binding GluN1 and glutamate-binding GluN2 subunits that gate in a concerted fashion, requiring all four ligands ..
  69. pmc Arrangement of subunits in functional NMDA receptors
    Catherine L Salussolia
    Graduate Program in Neuroscience, Center for Nervous System Disorders, State University of New York at Stony Brook, Stony Brook, New York 11794 5230, USA
    J Neurosci 31:11295-304. 2011
    ..GluN subunits are therefore positioned in a N1/N2/N1/N2 arrangement in functional NMDA receptors...
  70. doi Dissociation of AGAT, GAMT and SLC6A8 in CNS: relevance to creatine deficiency syndromes
    Olivier Braissant
    Inborn Errors of Metabolism, Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Neurobiol Dis 37:423-33. 2010
    ..This suggests that in most brain regions, guanidinoacetate is transported from AGAT- to GAMT-expressing cells through SLC6A8 to allow creatine synthesis, thereby explaining creatine deficiency in SLC6A8-deficient CNS...
  71. doi Arginine and glycine stimulate creatine synthesis in creatine transporter 1-deficient lymphoblasts
    Vincenzo Leuzzi
    Department of Child Neurology and Psychiatry, University of Rome La Sapienza, 00185 Rome, Italy
    Anal Biochem 375:153-5. 2008
    ..The greatest effect was obtained with 10 and 15 mM Arg and 10mM Arg plus Gly. These results encourage an in vivo trial with Cr precursors in CT1 defect...
  72. doi Glycine and taurine equally prevent fatty livers from Kupffer cell-dependent injury: an in vivo microscopy study
    Helge Bruns
    Department of General and Transplantation Surgery, Ruprecht Karls University, Heidelberg, Germany
    Microcirculation 18:205-13. 2011
    ..Since steatotic livers are prone to Kupffer cell-dependent IRI, protection of steatotic livers is of special interest. This study was designed to compare the effect of taurine and glycine on IRI in steatotic livers.
  73. pmc Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits
    Juan C Piña-Crespo
    Molecular Neurobiology Laboratory, Salk Institute, and Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:11501-5. 2010
    NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits...
  74. ncbi Glycine transporter-1: a new potential therapeutic target for schizophrenia
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Curr Pharm Des 17:112-20. 2011
    ..The glycine modulatory site on NMDA receptor complex is the one of the most attractive therapeutic targets for schizophrenia...
  75. doi Creatine metabolism and the urea cycle
    John T Brosnan
    Department of Biochemistry, Memorial University of Newfoundland, St John s, NL, Canada
    Mol Genet Metab 100:S49-52. 2010
    ..It is clear that patients with urea cycle disorders also have altered creatine metabolism. Whether this contributes in a significant way to their neurological symptoms remains an open question...
  76. pmc Mapping interactions between germinants and Clostridium difficile spores
    Amber Howerton
    Department of Chemistry, University of Nevada, Las Vegas, Las Vegas, Nevada 89154, USA
    J Bacteriol 193:274-82. 2011
    ..difficile-associated disease (CDAD). Taurocholate (a bile salt) and glycine (an amino acid) have been shown to be important germinants of C. difficile spores...
  77. doi Treatment of intractable epilepsy in a female with SLC6A8 deficiency
    Saadet Mercimek-Mahmutoglu
    Department of Pediatrics, Division of Biochemical Diseases, British Columbia Children s Hospital, UBC, Canada
    Mol Genet Metab 101:409-12. 2010
    ..Treatment with creatine monohydrate, to enhance cerebral creatine transport, combined with L-arginine and L-glycine, to enhance cerebral creatine synthesis, resulted in complete resolution of seizures...
  78. doi Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, ON, Canada M5G 1X5
    Pharmacol Biochem Behav 91:610-20. 2009
    Several compounds that promote activation of the N-methyl-d-aspartate receptor (NMDAR) glycine site have been proposed as treatments for schizophrenia, but the impact of these putative antipsychotics on anxiety remains unclear...
  79. doi The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Neurosci Biobehav Rev 34:351-72. 2010
    ..The NMDAR contains a D-serine/glycine site on the NR1 subunit that may be a promising therapeutic target for psychiatric illness...
  80. doi Effect of the herbicide glyphosate on glyphosate-tolerant maize rhizobacterial communities: a comparison with pre-emergency applied herbicide consisting of a combination of acetochlor and terbuthylazine
    Jorge Barriuso
    Centro Nacional de Biotecnologia CSIC, C Darwin 3, Campus de Universidad Autónoma, Cantoblanco, 28049 Madrid, Spain
    Environ Microbiol 12:1021-30. 2010
    ..The results obtained strongly suggest that both herbicides do in fact affect the maize rhizobacterial communities, glyphosate being, to a great extent, the environmentally less aggressive herbicide...
  81. pmc Functional diversity of the plant glycine-rich proteins superfamily
    Amanda Mangeon
    Laboratório de Genômica Funcional e Transdução de Sinal, Departamento de Genetica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Plant Signal Behav 5:99-104. 2010
    The first plant glycine-rich proteins (GRPs) have been isolated more than 20 years ago based on their specific expression pattern and/or modulation by several biotic and abiotic factors...
  82. pmc Dual personality of GABA/glycine-mediated depolarizations in immature spinal cord
    Céline Jean-Xavier
    Laboratoire Plasticité et Physio Pathologie de la Motricité, Centre National de la Recherche Scientifique, Aix Marseille Universite, 31 Chemin Joseph Aiguier, F 13402 Marseille Cedex 20, France
    Proc Natl Acad Sci U S A 104:11477-82. 2007
    The inhibitory action of glycine and GABA in adult neurons consists of both shunting incoming excitations and moving the membrane potential away from the action potential (AP) threshold...
  83. pmc Subunit-specific contribution of pore-forming domains to NMDA receptor channel structure and gating
    Alexander I Sobolevsky
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Gen Physiol 129:509-25. 2007
    ....
  84. pmc Intramolecular cohesion of coils mediated by phenylalanine--glycine motifs in the natively unfolded domain of a nucleoporin
    V V Krishnan
    Department of Applied Science, University of California Davis, Davis, California, United States of America
    PLoS Comput Biol 4:e1000145. 2008
    ..gate formed by a family of NPC proteins that feature large, natively unfolded domains with phenylalanine-glycine repeats (FG domains)...
  85. pmc Comparison of glycine and GABA actions on the zebrafish homomeric glycine receptor
    S Fucile
    INSERM U 261, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, Cedex 15, France
    J Physiol 517:369-83. 1999
    1. Glycine and GABA can be co-released from the same presynaptic terminals and in lower vertebrates they can activate the same glycine receptors (GlyRs)...
  86. ncbi Relation of plasma glycine, serine, and homocysteine levels to schizophrenia symptoms and medication type
    Guy Neeman
    Ezrath Nashim Herzog Memorial Hospital, P O Box 3900, Jerusalem 91035, Israel
    Am J Psychiatry 162:1738-40. 2005
    Altered glycine and homocysteine levels may contribute to N-methyl-D-aspartate receptor dysfunction in schizophrenia...
  87. pmc Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics
    Y Ji
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA
    Clin Pharmacol Ther 89:97-104. 2011
    ..Metabolomic assay of plasma samples from 20 escitalopram remitters and 20 nonremitters showed that glycine was negatively associated with treatment outcome (P = 0.0054)...
  88. pmc Molecular Insight into the Synergism between the Minor Allele of Human Liver Peroxisomal Alanine:Glyoxylate Aminotransferase and the F152I Mutation
    Barbara Cellini
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    J Biol Chem 284:8349-58. 2009
    ..aminotransferase (AGT) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that converts glyoxylate into glycine. AGT deficiency causes primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder, due to a marked ..
  89. pmc Deactivation of the Arabidopsis BRASSINOSTEROID INSENSITIVE 1 (BRI1) receptor kinase by autophosphorylation within the glycine-rich loop
    Man Ho Oh
    Department of Agriculture, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 109:327-32. 2012
    ..Many arginine-aspartate (RD)-type leucine-rich repeat receptor-like kinases have a phosphorylatable residue within the ATP-binding domain, suggesting that this mechanism may play a broad role in receptor kinase deactivation...
  90. pmc Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road N W, Washington, DC 20057, USA
    Glia 57:550-60. 2009
    ..These data indicate that microglial mGluR5 may represent a novel target for modulating neuroinflammation, an important component of both acute and chronic neurodegenerative disorders...
  91. pmc The genetic and molecular basis for sunscreen biosynthesis in cyanobacteria
    Emily P Balskus
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Science 329:1653-6. 2010
    ..In addition to clarifying the origin of the MAAs, these efforts have revealed two unprecedented enzymatic strategies for imine formation...
  92. pmc Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I
    Barbara Cellini
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134 Verona, Italy
    Proc Natl Acad Sci U S A 107:2896-901. 2010
    ..The detailed insight into how G41 mutations act on the structure-function of AGT may contribute to achieve the ultimate goal of correcting the effects of these mutations...
  93. pmc Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
    Hiroyasu Furukawa
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA
    EMBO J 22:2873-85. 2003
    ..NMDA receptors require both glycine and glutamate for activation with NR1 and NR2 forming glycine and glutamate sites, respectively...
  94. ncbi Parkinsonism, Lrrk2 G2019S, and tau neuropathology
    A Rajput
    Division of Neurology, University of Saskatchewan and Saskatoon Health Region, Saskatoon, Saskatchewan, Canada
    Neurology 67:1506-8. 2006
    ..Intriguingly, we observe no evidence of a direct interaction between either the tau or alpha-synuclein protein with Lrrk2...
  95. ncbi Presence of glutamate, glycine, and gamma-aminobutyric acid in the retina of the larval sea lamprey: comparative immunohistochemical study of classical neurotransmitters in larval and postmetamorphic retinas
    Verona Villar-Cerviño
    Departamento de Biología Celular y Ecología, Facultad de Biologia, Universidad de Santiago de Compostela, Santiago de Compostela 15782, Spain
    J Comp Neurol 499:810-27. 2006
    ..via immunocytochemistry using antibodies directed against the major candidate neurotransmitters [glutamate, glycine, gamma-aminobutyric acid (GABA), aspartate, dopamine, serotonin] and the neurotransmitter-synthesizing enzyme ..
  96. pmc Molecular basis for the herbicide resistance of Roundup Ready crops
    Todd Funke
    Department of Medicinal Chemistry, University of Kansas, Lawrence, 66045, USA
    Proc Natl Acad Sci U S A 103:13010-5. 2006
    ..Glyphosate sensitivity can be restored through a single-site mutation in the active site (Ala-100-Gly), allowing glyphosate to bind in its extended, inhibitory conformation...
  97. ncbi Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters
    Toshiaki Iba
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University School of Medicine, Urayasu, Chiba, Japan
    Shock 26:95-8. 2006
    ..05). Pretreatment of sivelestat demonstrated a protective effect on both intravascular and extravascular damage in the lung, whereas posttreatment only suppressed the latter damage...
  98. doi Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice
    Elisabet Jerlhag
    Section for Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, SE 405 30 Gothenburg, Sweden
    Drug Alcohol Depend 117:126-31. 2011
    ..As the target circuits for other drugs of abuse, including nicotine, in the brain includes this reward link, we sought to determine whether the central ghrelin signalling system is involved in nicotine's activation of this system...
  99. pmc Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail
    E Schonbrunn
    Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA
    Proc Natl Acad Sci U S A 98:1376-80. 2001
    ....
  100. ncbi Characterization of storage proteins in wild (Glycine soja) and cultivated (Glycine max) soybean seeds using proteomic analysis
    Savithiry S Natarajan
    Soybean Genomics and Improvement Laboratory, Agricultural Research Service, U S Department of Agriculture, PSI, Beltsville, Maryland 20705, USA
    J Agric Food Chem 54:3114-20. 2006
    ..separation, identification, and comparison of two major storage proteins, beta-conglycinin and glycinin, in wild (Glycine soja) and cultivated (Glycine max) soybean seeds...
  101. ncbi Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate
    Juliette Johnson
    Department of Ophthalmology, University of California School of Medicine, San Francisco, California 94143 0730, USA
    J Neurosci 23:518-29. 2003
    ..Glutamate is the prominent excitatory neurotransmitter in retina; GABA and glycine are the main inhibitory neurotransmitters...

Research Grants76

  1. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..to determine how DNE exaggerates the post-synaptic response of hypoglossal motoneurons to agonists of GABAA, glycine, NMDA and AMPA receptors...
  2. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2012
    ..These two metabolic processes are connected by the enzyme, glycine N-methyltransferase, which is abundant in liver, exocrine pancreas and prostate as well as in kidney and ..
  3. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2013
    ..phosphate (PLP), B6 plays essential roles in the acquisition and processing of one-carbon (1C) units by the glycine cleavage system and serine hydroxymethyltransferase, inter conversion and catabolism of amino acids, control of ..
  4. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    Activation of glycine receptors (GlyRs) in brain stem, spinal cord and brain provides a main inhibitory control for neuronal excitability...
  5. ROLE OF SAMe IN LIVER FUNCTION AND INJURY
    SHELLY CHI LOO LU; Fiscal Year: 2012
    ..In addition, we have preliminary data that show impaired SAMe metabolism, which occurs in glycine N- methyltransferase (GNMT) KO mice and patients with GNMT mutations, can lead to steatohepatitis, increased ..
  6. High affinity capturing agents for strychnine
    Kit S Lam; Fiscal Year: 2011
    ..Strychnine is a potent antagonist for the inhibitory glycine receptor, a ligand-gated chloride channel in the spinal cord and the brain...
  7. MIF AND THE HOST RESPONSE TO INFECTION
    RICHARD J BUCALA; Fiscal Year: 2013
    ..produces an MIF protein in which the catalytic proline that mediates tautomerase activity has been replaced by glycine (P1G-MIF)...
  8. GENETIC APPROACHES TO PROTEIN-NUCLEIC ACID INTERACTIONS
    Paul R Schimmel; Fiscal Year: 2012
    ..at understanding a key mechanism by which mammalian cells overcome their struggle to avoid confusing serine and glycine for alanine...
  9. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..The technology is based on the ability of synthetic polymers of N-substituted glycine termed 'peptoids'to serve as specific ligands for immunoglobulin...
  10. CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM
    CLARK ALGAIER; Fiscal Year: 2009
    ..With the TNP-tripeptide as substrate, the two reaction products, glycine-extended intermediate (TNP-D-Tyr-Val-&#945;-hydroxy-Gly) and the amidated TNP-dipeptide (TNP-D-Tyr-Val-NH2) ..
  11. Effect of D-cycloserine on treatment of PTSD in youth
    Michael S Scheeringa; Fiscal Year: 2010
    ..DCS), an antibiotic used to treat tuberculosis and urinary tract infections, is a partial agonist at the glycine modulatory site of the N-methyl- D-aspartic acid (NMDA) receptor...
  12. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
    ..for amphetamine, cocaine, and antidepressant drugs-as well as the transporters for GABA and glycine, which are targeted for treatment of epilepsy and schizophrenia. In 2005 the Gouaux group solved at 1...
  13. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    ..ex vivo (isolated sclera and RPE-choroid-sclera) models (2) to synthesize ester-peptide (Valine-, Valine-Valine-, Glycine-Valine-, and Tyrosine-Valine-) prodrugs of dexamethasone and prednisolone targeting peptide transporters present ..
  14. The consequences of loricrin deficiency on epidermal barrier function
    DENNIS ROOP; Fiscal Year: 2013
    ..However, none of these proteins could account for the high levels of glycine and serine present in LKO CEs, suggesting that as yet unidentified proteins must be induced...
  15. Cytoskeletal Keratins in Epithelial Immunity to Bacterial Keratitis
    K P CONNIE TAM; Fiscal Year: 2013
    ..That study led us to the discovery of a novel class of antimicrobial peptides (KDAMPs), which are glycine-rich C-terminal fragments of keratin 6A, a major intermediate filament protein found in the cytoskeleton of a ..
  16. NEUROPHYSIOLOGY OF PARASYMPATHETIC CARDIAC NEURONS
    David Mendelowitz; Fiscal Year: 2013
    ..we will test if CIH prolongs and exaggerates spontaneous and hypoxia evoked increases in inhibitory GABA and glycine pathways to CVNs;inhibits both spontaneously active excitatory pathways, as well as the excitation and activation ..
  17. Estrogen and TMJ Pain
    Phillip R Kramer; Fiscal Year: 2013
    ..resulted in a 16 to 34 fold increase in the GABAA receptor subunit [unreadable]6 (Gabr[unreadable]6), the glycine receptor subunit [unreadable]2 (Glr[unreadable]2) and the beta-adrenergic receptor subunit [unreadable]1 (Adr[..
  18. Host-associated regulation of P. aeruginosa colonization and virulence
    Deborah A Hogan; Fiscal Year: 2013
    ..PlcH-mediated degradation of host phopholipids provides the bacteria with precursors necessary to derive glycine betaine (GB)...
  19. Cell Communication of the Vertebrate Retina
    ROBERT FRANCIS MILLER; Fiscal Year: 2012
    ..has a genetic defect of the regulatory mechanisms of NMDA receptor coagonist function, including a deficiency in glycine transport, a deficiency in the degradation of D-serine (DAAO) and the absence of the synthetic machinery for D-..
  20. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2010
    ..substitute arginine and other positively charged amino acids from inverted reading frame 1 for the tyrosine and glycine that are normally encoded by the preferred reading frame 1 by deletion...
  21. Varicella zoster virus-Induced Pain in a Rat Model of Post-Herpetic Neuralgia
    Paul R Kinchington; Fiscal Year: 2013
    ..We will investigate the use of HSV vectors expressing pro-enkephalin, GAD, the glycine receptor, and anti inflammatory proteins to treat VZV-induced hypersensitivity in the model, all of which have ..
  22. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John H Eisenach; Fiscal Year: 2012
    ..We hypothesize that healthy individuals carrying the haplotype homozygous for glycine at position 16 (Gly16) and glutamate at position 27 (Glu27) (haplotype 1) will demonstrate greater cardiac output ..
  23. Molecular Genetics of Sideroblastic Anemia
    Mark D Fleming; Fiscal Year: 2013
    ..Specifically, evidence would suggest that SLC25A38 transports glycine, one of the substrates of the reaction catalyzed by ALAS2, into the erythroid mitochondrion to support very high-..
  24. Regulation of a Novel Trypanosome RNA Binding Protein by Arginine Methylation
    Kaylen Lott; Fiscal Year: 2013
    ..TbMiz1 contains a C-terminal arg/glycine-rich (RG) domain, a domain commonly targeted for arg methylation...
  25. Delivery of Soluble FGFR3 as a Treatment for Achondroplasia
    Steven C Ghivizzani; Fiscal Year: 2013
    ..the phenotype is caused by a specific point mutation in FGFR3, resulting in the substitution arginine for glycine at position 380 (Gly380Arg). This mutation is one of "gain-of-function," i.e...
  26. ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLE
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..fear conditioning) led to an upregulation of gephyrin mRNA, critical for the inhibitory neurotransmitters glycine and GABA...
  27. Searching for Novel Analgesic and Anti-inflammatory Agents
    Guigen Li; Fiscal Year: 2010
    ..Meanwhile, new chiral amino alcohols and diamines for N-acyl glycine and ethanolamide mimetics as well as their libraries will be synthesized...
  28. smFRET Investigation of Gating in a Neurotransmitter Transporter Homolog
    RACHEL ANN KOLSTER; Fiscal Year: 2013
    ..In addition, NSS for GABA and glycine are promising targets for the treatment of epilepsy and anxiety disorders or schizophrenia, respectively...
  29. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2012
    ..This DH incorporates tyrosine and glycine in preferred reading frame 1 (RF1)...
  30. Mechanism of action of novel GluN2C NMDA receptor potentiators
    Alpa Khatri; Fiscal Year: 2013
    ..The NMDA receptor is a heteromeric receptor formed by two glycine binding GluN1 and two glutamate binding GluN2 subunits...
  31. CFTR inhibitors for therapy of polycystic kidney disease
    Alan S Verkman; Fiscal Year: 2010
    ..has identified, by high-throughput screening, two classes of small-molecule CFTR inhibitors, thiazolidinones and glycine hydrazides, which, in published proof-of-concept studies, are effective in preventing cyst fluid accumulation in ..
  32. DEVELOPING SOLUTES AS STRUCTURAL/MECHANISTIC PROBES OF PROTEIN-DNA INTERACTIONS
    M Thomas Record; Fiscal Year: 2013
    ..Insight into the roles of E. coli osmolytes (e.g. Kglutamate, glycine betaine) in the biophysics of regulation of cytoplasmic volume and biopolymer volume fraction in response to ..
  33. Neurovascular Protection for Early Brain Injury after SAH
    John H Zhang; Fiscal Year: 2013
    ..is an extracellular matrix protein that can interact with cell surface integrin receptors through its arginine-glycine- aspartate (RGD) sequence and has been implicated in promoting cell survival, proliferation and reducing cellular ..
  34. Suppression of innate immunity by an ADP-ribosyltransferase type III effector
    JAMES ROBERT ALFANO; Fiscal Year: 2012
    ..Mass spectrometry determined that chloroplast and glycine-rich RNA-binding proteins acted as in vitro substrates for HopU1. These are novel substrates for ADP-RTs...
  35. Novel function and mechanism of CFTR in heart failure
    DAYUE DARREL DUAN; Fiscal Year: 2012
    ..b) targeted inactivation of CFTR decreases mitochondrial concentration of [unreadable]- glutamyl-cysteinyl-glycine ([GSH]mito), and c) CFTR-mediated changes in [GSH]mito are closely coupled to regulation of mitochondrial ..
  36. Fragile X Mental Retardation Protein translation regulator function: interactions
    MIHAELA R MIHAILESCU; Fiscal Year: 2013
    ..Biochemical studies have determined that FMRP uses its arginine-glycine- glycine (RGG) box to bind with high affinity to RNA sequences that form G quadruplex structures...
  37. Extra-translational roles of aminoacyl tRNA synthetases in connection to disease
    Xiang Lei Yang; Fiscal Year: 2013
    ..Interestingly, the residue on NEDD8 for conjugation to substrate is the C-terminal glycine, which is conserved in ubiquitin and in almost all ubiquitin-like proteins...
  38. A novel proteolytic system of pulmonary inflammation
    Amit Gaggar; Fiscal Year: 2013
    ..We have previously demonstrated that proline-glycine-proline (PGP) peptides can cause a robust PMN influx into the airways of mice;this cellular specificity is due to ..
  39. Cyr61-induced breast cancer: Clinical relevance and therapeutic development
    Ruth Lupu; Fiscal Year: 2010
    ..Additionally, we demonstrated that functional blockage of the Cyr61 integrin receptor alpha-v-beta3 with arginine-glycine-aspartate (RGD) peptidomimetics markedly decreases cell viability in MCF-7 cells engineered to overexpress Cyr61, ..
  40. PGP, A Possible Biomarker for COPD Exacerbations and or Progression
    J Edwin Blalock; Fiscal Year: 2013
    ..MMPs) and prolyl endopeptidase (PE) which degrade collagen and generate the PMN-specific matrikine, proline-glycine-proline (PGP). PGP then propagates further PMN influx and neutrophilic inflammation after IL-8 has subsided...
  41. Correcting glutathione deficiency to restore mitochondrial fat oxidation in aging
    RAJAGOPAL VISWANATH SEKHAR; Fiscal Year: 2013
    ..due to decreased synthesis, because of decreased availability of the GSH precursor amino acids cysteine and glycine. Supplementing the diet of these elderly subjects with cysteine and glycine for 2-weeks fully restored GSH ..
  42. NOC in processed meat as a likely cause of colon cancer
    Sidney S Mirvish; Fiscal Year: 2012
    ..We will synthesize and characterize the ANCP, N-1-glucosyl glycine, its N-nitroso derivative and analogs prepared from other sugars and amino acids...
  43. Ubiquitin-like Small Archaeal Protein Modification (SAMPylation)
    Julie A Maupin-Furlow; Fiscal Year: 2013
    ..of SAMPylation appears analogous in chemistry to ubiquitination based on the requirement of the C-terminal di-glycine motif of SAMP in covalent modification and the isolation of E1-, E2- and rhodanese-like SAMP conjugates...
  44. The Molecular Basis of Alcohol's Actions
    DAVID NIGEL JONES; Fiscal Year: 2010
    ..Finally we propose to investigate the interactions between alcohol and the transmembrane domains of the glycine receptor...
  45. Chronic Pain and Emotional Learning and Memory
    APKAR VANIA APKARIAN; Fiscal Year: 2012
    ..We will extend these findings by examining effects of effects of a glycine transporter blocker (sarcosine) on the same paradigms...
  46. The combined effects of zinc and ethanol at the glycine receptor
    Lindsay M McCracken; Fiscal Year: 2011
    ..Among the strongly-supported protein targets of ethanol are glycine receptors, which in addition to being modulated by alcohol and anesthetics, are also modulated by endogenous zinc...
  47. Structure of the GABA-A Receptor Binding Sites
    CYNTHIA M CZAJKOWSKI; Fiscal Year: 2013
    ..receptors (nAChR), serotonin-type-3 receptors (5HT3R), gamma-amino butyric acid type A receptors (GABAAR) and glycine receptors...
  48. Structure of the GABA-A Receptor Binding Sites
    CYNTHIA M CZAJKOWSKI; Fiscal Year: 2012
    ..receptors (nAChR), serotonin-type-3 receptors (5HT3R), gamma-amino butyric acid type A receptors (GABAAR) and glycine receptors...
  49. Metabolomics-Measured Urinary Metabolites, Diet and BP, 17 Random Samples
    LINDA VERNER VAN HORN; Fiscal Year: 2013
    ..metabolites distinguishing INTERMAP participants with lower and higher intakes of: glutamic acid, glycine, omega-3/omega-6 PFA and their specific PFAs, oleic acid/MFA, dietary Ca, Mg, P, non-heme Fe...
  50. In vitro screening of novel therapeutic agents for the treatment of alcohol abuse
    S John Mihic; Fiscal Year: 2010
    ..antagonize alcohol actions on the two protein targets we have selected for initial study: heteromeric 11/2 glycine receptors and heteromeric NR1/2B NMDA receptors...
  51. Functional Characterization of synaptic calcium/calmodulin kinase II (CaMKII) acc
    Jacqueline K Rose; Fiscal Year: 2010
    ..wave-like propagation of synaptic CaMKII accumulation that stems from localized application of glutamate and glycine to a small portion of dendrite, activating a subset of contiguous synapses...
  52. DNA and RNA Stability in Glycine Betaine, TMAO, and Urea Solutions: Correlating S
    JEFFREY JAMES contact SCHWINEFUS; Fiscal Year: 2010
    ..The investigations detailed in this proposal will quantify accumulation or exclusion of glycine betaine, trimethylamine oxide (TMAO), and urea at nucleic acid surfaces to correlate cosolute interactions with ..
  53. Effect of cysteine on glutathione production in critically ill neonates
    STEPHEN SHEW; Fiscal Year: 2010
    ..rates of erythrocyte glutathione utilizing a novel non-radioactive, stable isotope tracer technique with [13C]-glycine, (2) to measure plasma interleukin-6, tumor necrosis factor-a, and malondialdehyde concentrations as determinants ..
  54. MODEL SYNTHETIC CHANNEL ASSEMBLIES
    John M Tomich; Fiscal Year: 2013
    ..peptide sequences are distantly related to the pore-forming transmembrane segment (M2) of the spinal cord glycine receptor (GlyR) a1-subunit...
  55. Dynamics and Homeostasis of Glycinergic Synapses
    Dawnis M Chow; Fiscal Year: 2013
    ..b>Glycine plays the dominant inhibitory role in the spinal cord and few studies have addressed homeostatic regulation of ..
  56. Bacterial N-Acetyltransferases: Resistance to Regulation
    John S Blanchard; Fiscal Year: 2013
    ..This substrate will cause the undecynoylation of the 1-N-terminal glycine of what we estimate is 60 protein substrates, based on amino terminal sequence in yeast...
  57. Mechanisms of BMP Receptor Kinase Dysregulation in Skeletal Dysplasias
    JAY CLEMENS GROPPE; Fiscal Year: 2011
    ..In this context, Arg206 appears to form a highly conserved ion pair with Asp269, situated in the glycine-serine rich (GS) regulatory region adjacent to the inhibitory protein (FKBP12) binding interface...
  58. Analysis of a Burkholderia mallei Virulence-Associated Type VI Secretion System
    Paul J Brett; Fiscal Year: 2011
    ..Included amongst these are the valine-glycine repeat (VgrG) proteins which have been shown to behave both as structural components of the T6SS machinery and as ..
  59. Structure and Function of NMDA Receptors
    Hiroyasu Furukawa; Fiscal Year: 2013
    ..NMDA receptors are multimeric ligand-gated ion channels composed of NR1 and NR2 subunits that bind to glycine and L-glutamate at the extracellular domain (ATD/S1S2), respectively...
  60. DAAO Inhibitors for the treatment of Schizophrenia
    Takashi Tsukamoto; Fiscal Year: 2013
    ..provided by applicant): Cumulative evidence suggests that allosteric activation of the NMDA receptor through the glycine modulatory site provides new therapeutic potential for the treatment of schizophrenia...
  61. Novel estrogen receptor ligands from plant genomics
    John M Littleton; Fiscal Year: 2012
    ..expressing ERalpha/GFP, and in phase 2 we propose initially to apply this approach to hairy root cultures of Glycine max (soybean - known to contain high levels of ER ligands) and Cacalia plantaginea (a native plantain with high ..
  62. The Role of N-myristylation and N-terminal Modifications on PKA Structure and Dyn
    ADAM CHRISTOPHER BASTIDAS; Fiscal Year: 2013
    ..N- myristoylation is the irreversible covalent attachment of myristic acid onto the N-terminal glycine of proteins which typically occurs co-translationally...
  63. Renally Excreted Multimodal Core-Shell Silica Nanoparticles as Tumor-Selective Ra
    Ulrich Wiesner; Fiscal Year: 2013
    ..silica nanoparticles to achieve favorable melanoma receptor binding using variable numbers of cyclic arginine-glycine-aspartic acid-tyrosine (cRGDY) peptides, PEG chain lengths, and grafting densities;(2) investigate whether ..
  64. Prodrugs of NAAG Peptidase Inhibitors for the Treatment of Schizophrenia
    Jia Zhou; Fiscal Year: 2009
    ..Among these are activators of the glycine site on the NMDA receptor and group II metabotropic glutamate receptor (mGluR) agonists...
  65. SYNAPTIC MECHANISMS OF THE GLOBUS PALLIDUS
    RONALD HUFFMAN; Fiscal Year: 1980
    ..neurons to microiontophoretically applied putative inhibitory neurotransmitters lambda-aminobutyric acid (GABA), glycine, taurine and beta-alanine was studied...
  66. STUDIES OF NEURONAL AND GLIAL GLUTAMATE DECARBOXYLASES
    Jang Yen Wu; Fiscal Year: 1990
    ..the purification of the rate-limiting enzymes involved in the synthesis of gamma-aminobutyric acid (GABA), glycine, aspartate/glutamate, and taurine, namely L-glutamate decarboxylase (GAD), serine transhydroxymethylase (serine-..
  67. AGE RELATED SYNAPTIC CHANGES IN THE AUDITORY BRAINSTEM
    Robert Helfert; Fiscal Year: 1999
    ..The neurotransmitter gamma-aminobutyric acid (GABA), along with glycine and the excitant amino acids (EAAs) have been shown to be essential for coding many of these important auditory ..
  68. SITES OF ANESTHETIC ACTION IN INHIBITORY RECEPTORS
    Eric Greenblatt; Fiscal Year: 2002
    ..ability to potentiate neuronal inhibition mediated by the neurotransmitters gamma-aminobutyric acid (GABA) and glycine at GABAa and glycine receptors, respectively...
  69. SPERM GLYCINE RECEPTORS AND ZONA-INITIATED EXOCYTOSIS
    Stanley Meizel; Fiscal Year: 2006
    The mammalian acrosome reaction (AR) is a sperm head exocytotic event essential to fertilization. A neuronal glycine receptor/Cl channel (GlyR) is present in mammalian sperm and is necessary for the AR initiated by the egg zona pellucida ..
  70. RESPIRATORY SYSTEM INTEGRATION BY THE BRAINSTEM
    ALBERT BERGER; Fiscal Year: 2002
    ..This application focuses on glycine and gamma-aminobutyric acid (GABA) ligand-gated receptors (glycine-Rs and GABAA-Rs, respectively)...
  71. ONTOGENY OF FETAL HEPATIC SERINE AND GLYCINE METABOLISM
    Michael Narkewicz; Fiscal Year: 1999
    ..We have focused our studies on serine and glycine, two amino acids with unique fetal characteristics...
  72. Identification of Novel Alpha Amidated Peptide Hormones
    ANGELO CONSALVO; Fiscal Year: 2007
    ..PAM catalyzes the conversion of glycine-extended peptides to the corresponding peptide-amide...
  73. GLYCINE POTENTIATION OF ANTICONVULSANT DRUGS
    Steven Peterson; Fiscal Year: 1991
    The 2 goals of the proposed research are to determine if: (1) systemically administered glycine potentiates the activity of anticonvulsant drugs in experimental models of epilepsy; (2) the glycine potentiation is mediated by a GABAergic ..
  74. Functional studies of the Fragile X Mental Retardation Protein: switching from re
    Mihaela Mihailescu; Fiscal Year: 2009
    ..Biochemical studies have determined that FMRP uses its arginine-glycine-glycine (RGG) box to bind with high affinity to RNA sequences that have the potential to form G quadruplex ..
  75. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2002
    ..Agonists of the strychnine-insensitive NMDA receptor glycine site offer a safe method to facilitate NMDA receptor function...
  76. ETHANOL AND NMDA RECEPTOR FUNCTION
    RUEBEN GONZALES; Fiscal Year: 1999
    ..The specific aims of this proposal are to determine (l) whether endogenous glycine agonists interact with the ability of acute ethanol to inhibit NMDA receptor function in vivo, (2) if acute ..