tyrosine

Summary

Summary: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.

Top Publications

  1. ncbi Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
    John Rush
    Cell Signaling Technology Inc, 166B Cummings Center, Beverly, Massachusetts 01915, USA
    Nat Biotechnol 23:94-101. 2005
  2. ncbi Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    Z Zhong
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
    Science 264:95-8. 1994
  3. pmc L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, Memphis, TN, USA
    Pigment Cell Melanoma Res 25:14-27. 2012
  4. ncbi Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    J Raingeaud
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    J Biol Chem 270:7420-6. 1995
  5. pmc Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses
    Li Zhong
    Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 105:7827-32. 2008
  6. ncbi Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif
    Ruth Rollason
    Department of Biochemistry, University of Bristol, Bristol, BS8 1T, UK
    J Cell Sci 120:3850-8. 2007
  7. pmc In vivo protein tyrosine nitration in Arabidopsis thaliana
    Jorge Lozano-Juste
    Instituto de Biologia Molecular y Celular de Plantas, CSIC Universidad Politecnica de Valencia, CPI Ed 8E, Camino de Vera s n, 46022 Valencia, Spain
    J Exp Bot 62:3501-17. 2011
  8. doi Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
    Carsten Janke
    Department of Signalling, Neurobiology and Cancer, Institut Curie, Bat 110, Centre Universitaire, 91405 Orsay Cedex, France
    Nat Rev Mol Cell Biol 12:773-86. 2011
  9. doi CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II
    Andreas Mayer
    Gene Center and Department of Biochemistry, Center for Integrated Protein Science Munich, Ludwig Maximilians Universitat Munchen, Feodor Lynen Strasse 25, 81377 Munich, Germany
    Science 336:1723-5. 2012
  10. ncbi Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
    G Levkowitz
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell 4:1029-40. 1999

Research Grants

  1. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
  2. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
  3. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
  4. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
  5. CLIFFORD RUSSELL GREYSON; Fiscal Year: 2016
  6. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
  7. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
  8. Michael Demetriou; Fiscal Year: 2014
  9. Mitchell Kronenberg; Fiscal Year: 2014
  10. Maria Diakonova; Fiscal Year: 2014

Detail Information

Publications403 found, 100 shown here

  1. ncbi Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
    John Rush
    Cell Signaling Technology Inc, 166B Cummings Center, Beverly, Massachusetts 01915, USA
    Nat Biotechnol 23:94-101. 2005
    b>Tyrosine kinases play a prominent role in human cancer, yet the oncogenic signaling pathways driving cell proliferation and survival have been difficult to identify, in part because of the complexity of the pathways and in part because of ..
  2. ncbi Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    Z Zhong
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
    Science 264:95-8. 1994
    ..A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon ..
  3. pmc L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, Memphis, TN, USA
    Pigment Cell Melanoma Res 25:14-27. 2012
    There is evidence that L-tyrosine and L-dihydroxyphenylalanine (L-DOPA), besides serving as substrates and intermediates of melanogenesis, are also bioregulatory agents acting not only as inducers and positive regulators of melanogenesis ..
  4. ncbi Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    J Raingeaud
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    J Biol Chem 270:7420-6. 1995
    ..Immunofluorescence microscopy demonstrated that p38 MAP kinase is present in both the nucleus and cytoplasm of activated cells. Together, these data establish that p38 is a member of the mammalian MAP kinase group...
  5. pmc Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses
    Li Zhong
    Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 105:7827-32. 2008
    ..We have reported that epidermal growth factor receptor protein tyrosine kinase (EGFR-PTK) signaling negatively affects transduction by AAV2 vectors by impairing nuclear transport of the ..
  6. ncbi Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif
    Ruth Rollason
    Department of Biochemistry, University of Bristol, Bristol, BS8 1T, UK
    J Cell Sci 120:3850-8. 2007
    ..protein is internalised through a clathrin-dependent pathway, internalisation is dependent upon a novel dual-tyrosine-based motif in the cytosolic domain of CD317, the cytosolic domain of CD317 can interact with the mu subunits of ..
  7. pmc In vivo protein tyrosine nitration in Arabidopsis thaliana
    Jorge Lozano-Juste
    Instituto de Biologia Molecular y Celular de Plantas, CSIC Universidad Politecnica de Valencia, CPI Ed 8E, Camino de Vera s n, 46022 Valencia, Spain
    J Exp Bot 62:3501-17. 2011
    Nitration of tyrosine (Y) residues of proteins is a low abundant post-translational modification that modulates protein function or fate in animal systems...
  8. doi Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
    Carsten Janke
    Department of Signalling, Neurobiology and Cancer, Institut Curie, Bat 110, Centre Universitaire, 91405 Orsay Cedex, France
    Nat Rev Mol Cell Biol 12:773-86. 2011
    ....
  9. doi CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II
    Andreas Mayer
    Gene Center and Department of Biochemistry, Center for Integrated Protein Science Munich, Ludwig Maximilians Universitat Munchen, Feodor Lynen Strasse 25, 81377 Munich, Germany
    Science 336:1723-5. 2012
    ..These results show that CTD modifications trigger and block factor recruitment and lead to an extended CTD code that explains transcription cycle coordination on the basis of differential phosphorylation of Tyr(1), Ser(2), and Ser(5)...
  10. ncbi Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
    G Levkowitz
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell 4:1029-40. 1999
    ..This is followed by tyrosine phosphorylation of c-Cbl at a site flanking its RING finger, which enables receptor ubiquitination and ..
  11. ncbi Protein tyrosine phosphatases in the human genome
    Andres Alonso
    Program of Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 117:699-711. 2004
    b>Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome...
  12. pmc Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center, and Departmentof Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 24:5434-46. 2004
    ..In concordance with these increases by LPS, tyrosine phosphorylation of the insulin receptor (IR) is partially impaired and phosphorylation of the insulin receptor ..
  13. doi Cyclic adenosine monophosphate-independent tyrosine phosphorylation of NR2B mediates cocaine-induced extracellular signal-regulated kinase activation
    Vincent Pascoli
    Centre National de la Recherche Scientifique Unite Mixte de Recherche, Paris, France
    Biol Psychiatry 69:218-27. 2011
    ..However, the mechanisms responsible for this activation, especially the respective contribution of D1R and NMDAR, remain unknown...
  14. pmc Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif
    Chenqi Xu
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 135:702-13. 2008
    Many immune system receptors signal through cytoplasmic tyrosine-based motifs (ITAMs), but how receptor ligation results in ITAM phosphorylation remains unknown...
  15. pmc Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
    The occurrence of protein tyrosine nitration under disease conditions is now firmly established and represents a shift from the signal transducing physiological actions of (.)NO to oxidative and potentially pathogenic pathways...
  16. pmc Tyrosine phosphorylation: thirty years and counting
    Tony Hunter
    The Salk Institute, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 21:140-6. 2009
    In the 30 years since its discovery, tyrosine phosphorylation has emerged as a fundamentally important mechanism of signal transduction and regulation in all eukaryotic cells, governing many processes, including cell proliferation, cell ..
  17. pmc Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression
    Justin M Drake
    Department of Microbiology, Immunology, and Molecular Genetics, Crump Institute for Molecular Imaging, Institute for Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 109:1643-8. 2012
    Dominant mutations or DNA amplification of tyrosine kinases are rare among the oncogenic alterations implicated in prostate cancer...
  18. pmc Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event
    Adam Cole
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 377:249-55. 2004
    ..inhibitor, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4- d ]pyrimidine (PP2), or a general protein tyrosine kinase inhibitor (genistein)...
  19. ncbi Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine
    F Yamakura
    Department of Chemistry, Juntendo University School of Medicine, Inba, Chiba 270 16, Japan
    J Biol Chem 273:14085-9. 1998
    ..This study proposes that nitration of a specific tyrosine residue is responsible for inactivation of recombinant human mitochondrial manganese-superoxide dismutase (Mn-SOD)..
  20. pmc Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors
    S Costagliola
    I R I B H N and Department of Medical Genetics, ULB, 808 Lennik Street, B 1070 Brussels, Belgium
    EMBO J 21:504-13. 2002
    ..Site-directed mutagenesis experiments indicate that the motif, which is conserved in all members of the glycoprotein hormone receptor family, seems to play a similar role in the LH/CG and FSH receptors...
  21. ncbi c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs
    Markus Stein
    IRIS Chiron S p A, Via Fiorentina 1, 53100 Siena, Italy
    Mol Microbiol 43:971-80. 2002
    ..Following transfer, CagA is phosphorylated on tyrosine residues by a host cell kinase...
  22. ncbi Biochemistry of protein tyrosine nitration in cardiovascular pathology
    Gonzalo Peluffo
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Cardiovasc Res 75:291-302. 2007
    ..Proteins nitrated at tyrosine residues have been detected in several compartments of the cardiovascular system...
  23. ncbi The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
    Benjamin G Neel
    Cancer Biology Program Division of Hematology Oncology Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Trends Biochem Sci 28:284-93. 2003
    Src homology-2 (SH2) domain-containing phosphatases (Shps) are a small, highly conserved subfamily of protein-tyrosine phosphatases, members of which are present in both vertebrates and invertebrates...
  24. ncbi Regulation of androgen receptor activity by tyrosine phosphorylation
    Zhiyong Guo
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Cell 10:309-19. 2006
    The androgen receptor (AR) is essential for the growth of prostate cancer cells. Here, we report that tyrosine phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors...
  25. ncbi MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
    Pearl Gray
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 281:10489-95. 2006
    ..When overexpressed we have found that Mal undergoes tyrosine phosphorylation...
  26. pmc Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
    M D Schaller
    Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville 22908
    Mol Cell Biol 14:1680-8. 1994
    The phosphorylation of protein tyrosine kinases (PTKs) on tyrosine residues is a critical regulatory event that modulates catalytic activity and triggers the physical association of PTKs with Src homology 2 (SH2)-containing proteins...
  27. pmc A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases
    Silke Wiesner
    Structural Biology and Biochemistry, Hospital for Sick Children, Toronto, Ontario, Canada
    EMBO J 25:4686-96. 2006
    Eph receptor tyrosine kinases (RTKs) mediate numerous developmental processes. Their activity is regulated by auto-phosphorylation on two tyrosines within the juxtamembrane segment (JMS) immediately N-terminal to the kinase domain (KD)...
  28. pmc Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth
    Jonathan Degeer
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 33:739-51. 2013
    ..Together, these findings demonstrate that Trio(Y2622) phosphorylation is essential for the regulation of the DCC/Trio signaling complex in cortical neurons during netrin-1-mediated axon outgrowth...
  29. ncbi Interaction of tyrosine-based sorting signals with clathrin-associated proteins
    H Ohno
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Science 269:1872-5. 1995
    b>Tyrosine-based signals within the cytoplasmic domain of integral membrane proteins mediate clathrin-dependent protein sorting in the endocytic and secretory pathways...
  30. ncbi SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
    Jens M Chemnitz
    Abramson Family Cancer Research Institute and Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 173:945-54. 2004
    ..The cytoplasmic tail of PD-1 contains two structural motifs, an ITIM and an immunoreceptor tyrosine-based switch motif (ITSM). Mutation of the ITIM had little effect on PD-1 signaling or functional activity...
  31. doi Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau
    Alessia Usardi
    Department of Neuroscience, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King s College London, UK
    FEBS J 278:2927-37. 2011
    ..reports have demonstrated that interactions between the microtubule-associated protein tau and the nonreceptor tyrosine kinase Fyn play a critical role in mediating synaptic toxicity and neuronal loss in response to β-amyloid (Aβ) ..
  32. pmc Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes
    Ahmed Bettaieb
    Department of Nutrition, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e34412. 2012
    Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and body mass, and has been implicated in endoplasmic reticulum (ER) stress...
  33. pmc Protein tyrosine nitration: biochemical mechanisms and structural basis of functional effects
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Acc Chem Res 46:550-9. 2013
    In proteins, the nitration of tyrosine residues to 3-nitro-tyrosine represents an oxidative post-translational modification that disrupts nitric oxide ((•)NO) signaling and skews metabolism towards pro-oxidant processes...
  34. pmc A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5
    M Farzan
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 72:1160-4. 1998
    ..Here we identify a small tyrosine-rich region of CCR5 proximal to the N-terminal cysteine that is critical for entry of macrophage-tropic and dual-..
  35. pmc Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
    Taro Hitosugi
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Sci Signal 2:ra73. 2009
    ..To better understand how tyrosine kinase signaling, which is commonly increased in tumors, regulates the Warburg effect, we performed ..
  36. pmc Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
    Kiran Mahajan
    Drug Discovery Program, Moffitt Cancer Center, Tampa, Florida, United States of America
    PLoS ONE 5:e9646. 2010
    ..Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosphatidylinositol-3-OH kinase (PI3K) activation or loss of Phosphatase and Tensin ..
  37. pmc MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA
    Jianmin Meng
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 285:27935-43. 2010
    ..Thus, surface charge differences at the two MD-2/TLR4 interfaces determine the species-specific activation of lipid IV(A)...
  38. ncbi Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
    K Shuai
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021
    Cell 76:821-8. 1994
    ..of transcription) is inactive in the cytoplasm of untreated cells but is activated by phosphorylation on tyrosine in response to a number of polypeptide ligands, including interferon alpha (IFN-alpha) and IFN-gamma...
  39. pmc High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors
    Hilda Petrs-Silva
    Department of Ophthalmology, University of Florida, Gainesville, Florida 32610 0284, USA
    Mol Ther 17:463-71. 2009
    ..Recently, it was shown that phosphorylation of surface-exposed tyrosine residues from AAV2 capsid targets the viral particles for ubiquitination and proteasome- mediated degradation, ..
  40. pmc Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth
    Tsai Der Chuang
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Biol Chem 285:23598-606. 2010
    Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2...
  41. pmc Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity
    Sushma J Bhakta
    Emory Vaccine Center at the Yerkes National Primate Research Center and Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30329, USA
    Retrovirology 8:37. 2011
    ..Virus (HIV) envelope glycoprotein (Env) contains a long cytoplasmic domain (CD) with multiple highly conserved tyrosine (Y) and dileucine (LL) motifs...
  42. pmc Glutamine synthetase is a molecular target of nitric oxide in root nodules of Medicago truncatula and is regulated by tyrosine nitration
    Paula M Melo
    Instituto de Biologia Molecular e Celular da Universidade do Porto, 4150 180 Porto, Portugal
    Plant Physiol 157:1505-17. 2011
    ..root nodule metabolism, is a molecular target of NO in root nodules of Medicago truncatula, being regulated by tyrosine (Tyr) nitration in relation to active nitrogen fixation...
  43. pmc STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
    J Chung
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 17:6508-16. 1997
    ..STAT3 serine phosphorylation, not its tyrosine phosphorylation, results in retarded mobility of the STAT3 protein on sodium dodecyl sulfate-polyacrylamide gel ..
  44. doi Inside the human cancer tyrosine phosphatome
    Sofi G Julien
    Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Nat Rev Cancer 11:35-49. 2011
    Members of the protein tyrosine phosphatase (Ptp) family dephosphorylate target proteins and counter the activities of protein tyrosine kinases that are involved in cellular phosphorylation and signalling...
  45. ncbi Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
    M Farzan
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:667-76. 1999
    ..Each of these otherwise diverse coreceptors contains an N-terminal region that is acidic and tyrosine rich...
  46. ncbi Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    T Hiesberger
    Department of Molecular Genetics, UT Southwestern Dallas, Texas 75235, USA
    Neuron 24:481-9. 1999
    ..of VLDLR and ApoER2 in vitro and that blockade of VLDLR and ApoER2 correlates with loss of Reelin-induced tyrosine phosphorylation of Disabled-1 in cultured primary embryonic neurons...
  47. ncbi Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB
    Maristela Lika Onozato
    Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
    Kidney Int 61:186-94. 2002
    ..We tested the hypothesis that Ang II subtype 1 (AT1) receptor activation enhances oxidative stress and nitrotyrosine deposition in the kidneys of rats with diabetes mellitus (DM)...
  48. pmc c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs
    Antje Ostareck-Lederer
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell Biol 22:4535-43. 2002
    ..We show that hnRNP K and the c-Src kinase specifically interact with each other, leading to c-Src activation and tyrosine phosphorylation of hnRNP K in vivo and in vitro...
  49. ncbi Post-translational modifications regulate microtubule function
    Stefan Westermann
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Rev Mol Cell Biol 4:938-47. 2003
  50. pmc Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
    Chih Chin Huang
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:2706-11. 2004
    ..mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-..
  51. pmc FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion
    Keefe T Chan
    Department of Molecular and Cellular Pharmacology, University of Wisconsin, Madison, WI 53706, USA
    J Cell Biol 185:357-70. 2009
    ..of invadopodia that are rescued by expression of wild-type FAK but not by FAK that cannot be phosphorylated at tyrosine 397...
  52. pmc Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer
    Lei Zheng
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 6:e19390. 2011
    ..Furthermore, cell-surface localization of ANXA2 is tyrosine 23 phosphorylation-dependent; and tyrosine 23 phosphorylation is required for PDA invasion...
  53. ncbi JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
    B A Witthuhn
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Cell 74:227-36. 1993
    ..Although EPOR is a member of the cytokine receptor superfamily and lacks a kinase domain, EPO induces tyrosine phosphorylation, which is correlated with gene transcription and mitogenesis...
  54. doi Annexin A2 binding to endosomes and functions in endosomal transport are regulated by tyrosine 23 phosphorylation
    Etienne Morel
    Department of Biochemistry, University of Geneva, Sciences II, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
    J Biol Chem 284:1604-11. 2009
    ..We found that endosomal AnxA2 was partially tyrosine-phosphorylated and that mutation of Tyr-23 to Ala (AnxA2Y23A), but not of Ser-25 to Ala, impaired AnxA2 endosome ..
  55. doi Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells
    Falko Hochgräfe
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital Clinical School and Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, New South Wales, Australia
    Cancer Res 70:9391-401. 2010
    ..for basal breast cancers, breast cancer cell lines were subjected to mass spectrometry-based profiling of protein tyrosine phosphorylation events...
  56. ncbi Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state
    Matthew D Potter
    Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    J Biol Chem 280:31906-12. 2005
    ..We show here that tyrosine phosphorylation of the adherens junction protein VE-cadherin at two critical tyrosines, Tyr-658 and Tyr-731, via ..
  57. pmc Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases
    M B Calalb
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Mol Cell Biol 15:954-63. 1995
    Focal adhesion kinase (FAK) is a widely expressed nonreceptor protein-tyrosine kinase implicated in integrin-mediated signal transduction pathways and in the process of oncogenic transformation by v-Src...
  58. ncbi Glycogen synthase kinase 3beta is tyrosine phosphorylated by PYK2
    J A Hartigan
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0017, USA
    Biochem Biophys Res Commun 284:485-9. 2001
    ..GSK3beta is activated by tyrosine phosphorylation...
  59. pmc PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
    T Okazaki
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan
    Proc Natl Acad Sci U S A 98:13866-71. 2001
    PD-1 is an immunoreceptor that belongs to the immunoglobulin (Ig) superfamily and contains two tyrosine residues in the cytoplasmic region...
  60. ncbi Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase
    Hyun Jung Choi
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1240 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    J Mol Biol 343:1255-68. 2004
    ..Targeting the Nef hydrophobic pocket with a small molecule may be sufficient to disrupt Nef signaling through Hck in HIV-infected macrophages, slowing disease progression...
  61. ncbi Protein-tyrosine phosphatases and cancer
    Arne Ostman
    Cancer Center Karolinska, Department of Pathology and Oncology, Karolinska Institutet, Stockholm, Sweden
    Nat Rev Cancer 6:307-20. 2006
    b>Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer drugs have been introduced that target these enzymes...
  62. ncbi Protein tyrosine phosphatases: from genes, to function, to disease
    Nicholas K Tonks
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Rev Mol Cell Biol 7:833-46. 2006
    The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes...
  63. ncbi Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF
    D R Kaplan
    Eukaryotic Signal Transduction Group, NCI Frederick Cancer Research and Development Center, Maryland 21701
    Nature 350:158-60. 1991
    ..Several experiments using the NGF-responsive pheochromocytoma cell line, PC12, have implicated tyrosine phosphorylation in NGF-mediated responses, although no NGF-specific tyrosine kinases have been identified...
  64. ncbi Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    S Akira
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Cell 77:63-71. 1994
    ..The cloned APRF protein is tyrosine phosphorylated and translocated into the nucleus in response to IL-6, but not in response to IFN-gamma...
  65. ncbi A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation
    Pamela A Lochhead
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD
    Mol Cell 24:627-33. 2006
    ..Kinase activity is thought to be increased by intramolecular phosphorylation of a tyrosine in the activation loop (Y216 in GSK3beta), whose timing and mechanism is undefined...
  66. pmc Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation
    K Hughes
    Ludwig Institute for Cancer Research, London, UK
    EMBO J 12:803-8. 1993
    ..Here, we demonstrate that these two proteins and the fruit fly protein are phosphorylated on tyrosine in vivo. Moreover, GSK-3 beta activity and function are shown to be dependent on tyrosine phosphorylation...
  67. ncbi Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase
    Yasunari Takada
    Department of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:24233-41. 2003
    ..We found that H2O2 induced the tyrosine phosphorylation of IkappaBalpha, which is needed for NF-kappaB activation...
  68. ncbi Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling
    Laure Dumoutier
    Ludwig Institute for Cancer Research, Brussels Branch and the Experimental Medicine Unit, Universite de Louvain, B 1200 Brussels, Belgium
    J Biol Chem 279:32269-74. 2004
    ..interleukin-28R/likely interleukin or cytokine or receptor 2 (IL-28R/LICR2) and IL-10R beta, and mediates the tyrosine phosphorylation of STAT1, STAT2, STAT3, and STAT5...
  69. ncbi The discoidin domain receptor tyrosine kinases are activated by collagen
    W Vogel
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell 1:13-23. 1997
    Two mammalian receptor tyrosine kinases (DDR1 and DDR2) have extracellular domains closely related to a D. discoideum lectin, discoidin, required for cell aggregation...
  70. pmc Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4
    Chih Chin Huang
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 317:1930-4. 2007
    ..Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120...
  71. pmc Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells
    Haiyu Li
    Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China
    BMC Cancer 9:366. 2009
    Aberrant activity of tyrosine-phosphorylated proteins is commonly associated with HCC metastasis. Cell signaling events driven by these proteins are implicated in numerous processes that alter cancer cell behavior...
  72. pmc The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases
    Navasona Krishnan
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724 2208, USA
    FEBS J 280:2830-41. 2013
    The families of protein tyrosine phosphatases (PTPs) and protein tyrosine kinases (PTKs) function in a coordinated manner to regulate signal transduction events that are critical for cellular homeostasis...
  73. doi Protein tyrosine phosphatases: structure, function, and implication in human disease
    Lutz Tautz
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Methods Mol Biol 1053:179-221. 2013
    Protein tyrosine phosphorylation is a key regulatory mechanism in eukaryotic cell physiology...
  74. ncbi Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin
    Lu Gang Yu
    Departments of Medicine and Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3GA, UK
    J Biol Chem 279:41377-83. 2004
    ..beta1-3 N-acetylgalactosamine alpha-), we have found that this lectin (30 microg/ml) induces rapid, transient, tyrosine phosphorylation of putative human HLA-DR-associated protein I (PHAPI, also known as the tumor suppressor pp32) in ..
  75. doi Improved electrospray ionization efficiency compensates for diminished chromatographic resolution and enables proteomics analysis of tyrosine signaling in embryonic stem cells
    Scott B Ficarro
    Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Smith 1158A, Boston, Massachusetts 02115 6084, USA
    Anal Chem 81:3440-7. 2009
    ..Identification of tyrosine signaling cascades is of particular interest but is complicated by the relatively low levels of tyrosine ..
  76. pmc Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina
    Hilda Petrs-Silva
    Department of Ophthalmology, University of Florida, Gainesville, FL, USA
    Mol Ther 19:293-301. 2011
    ..present study, we evaluated the transduction characteristics of AAV2 vectors containing combinations of multiple tyrosine to phenylalanine mutations in seven highly conserved surface-exposed capsid tyrosine residues following ..
  77. pmc Modular engineering of L-tyrosine production in Escherichia coli
    Darmawi Juminaga
    California Institute for Quantitative Biosciences and Berkeley Center for Synthetic Biology, University of California, Berkeley, California, USA
    Appl Environ Microbiol 78:89-98. 2012
    Efficient biosynthesis of L-tyrosine from glucose is necessary to make biological production economically viable. To this end, we designed and constructed a modular biosynthetic pathway for L-tyrosine production in E...
  78. pmc S-nitrosylation of peroxiredoxin II E promotes peroxynitrite-mediated tyrosine nitration
    Maria C Romero-Puertas
    Dipartimento Scientifico e Tecnologico, Universita degli Studi di Verona, 37134 Verona, Italy
    Plant Cell 19:4120-30. 2007
    ....
  79. pmc Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment
    Béatrice Sulka
    IFR128 BioSciences Gerland Lyon Sud, Institut de Biologie et Chimie des Proteines, UMR 5086, CNRS, Université Lyon1, 7 passage du Vercors, 69367 Lyon, France
    J Biol Chem 284:10659-71. 2009
    ..Here we show that syndecan-1-mediated formation of membrane protrusions requires dephosphorylation of tyrosine residues in syndecan-1...
  80. pmc Adeno-associated virus serotype 6 capsid tyrosine-to-phenylalanine mutations improve gene transfer to skeletal muscle
    Chunping Qiao
    Division of Molecular Pharmaceutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC 27599, USA
    Hum Gene Ther 21:1343-8. 2010
    ..Selective mutation of AAV capsid surface-exposed tyrosine (Y) is a novel strategy to improve transduction efficiency...
  81. doi High temperature triggers the metabolism of S-nitrosothiols in sunflower mediating a process of nitrosative stress which provokes the inhibition of ferredoxin-NADP reductase by tyrosine nitration
    Mounira Chaki
    Grupo de Señalización Molecular y Sistemas Antioxidantes en Plantas, Unidad Asociada al CSIC, Departamento de Bioquimica y Biologia Molecular, Universidad de Jaén E 23071 Jaén, Spain
    Plant Cell Environ 34:1803-18. 2011
    ..However, the content of tyrosine nitration (NO(2) -Tyr) studied by high-performance liquid chromatography with tandem mass spectrometry (LC-MS/MS) ..
  82. pmc Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading
    Fumin Chang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e28587. 2011
    ..The activity of the Rho family member Cdc42 has been shown to be modulated by tyrosine phosphorylation at position 64...
  83. ncbi Detection of nitrotyrosine in the diabetic plasma: evidence of oxidative stress
    A Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Italy
    Diabetologia 44:834-8. 2001
    ..Peroxynitrite is responsible for nitration of tyrosine residues in proteins...
  84. pmc Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin
    Greg P Coffey
    Stanford University, School of Medicine, Division of Oncology, Stanford, CA 94305, USA
    J Cell Sci 122:3137-44. 2009
    ..We engaged CD81 on the surface of B-lymphocytes and identified the induced tyrosine-phosphorylated proteins by mass spectrometry...
  85. pmc Identification and characterization of repetitive extragenic palindromes (REP)-associated tyrosine transposases: implications for REP evolution and dynamics in bacterial genomes
    Jaroslav Nunvar
    Department of Genetics and Microbiology, Faculty of Science, Charles University, Vinicna 5, 128 44 Prague 2, Czech Republic
    BMC Genomics 11:44. 2010
    ..BIMEs and REPs have been shown to serve as binding sites for several proteins and suggested to play role in chromosome organization and transcription termination. Their origins are, at present, unknown...
  86. pmc Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity
    Galit Lazer
    Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada IMRIC, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Biol Chem 285:23075-85. 2010
    ..It is also involved in several human malignancies. Tyrosine phosphorylation at the Vav1 amino terminus plays a central role in regulating its activity; however, the role of ..
  87. pmc Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle
    Genevieve Pilon
    Department of Medicine, Quebec Heart and Lung Institute Laval Hospital, Ste Foy, Quebec, Canada
    PLoS ONE 5:e15912. 2010
    ..Here we examined the role of inducible nitric oxide synthase (iNOS) in skeletal muscle insulin resistance using LPS challenge in rats and mice as in vivo models of endotoxemia...
  88. doi Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation
    Markus P Kummer
    Clinical Neuroscience Unit, Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Neuron 71:833-44. 2011
    ..Under pathological conditions there is a shift from the signal transducing actions to the formation of protein tyrosine nitration by secondary products like peroxynitrite and nitrogen dioxide...
  89. pmc Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
    Wenqi Wang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
    BMC Cell Biol 12:49. 2011
    ..However, the mechanisms involved in the attachment of actin filaments to focal adhesions are still not fully understood...
  90. pmc Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance
    Wenji Piao
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 283:3109-19. 2008
    ..In this study we examined whether tyrosine phosphorylation of Mal regulates its interactions with TLR4, MyD88, interleukin-1 (IL-1) receptor-associated ..
  91. pmc Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885)
    Akihiro Ueda
    Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, Texas, United States of America
    PLoS Pathog 5:e1000483. 2009
    ..formation; hence, we provide a mechanism for quorum sensing control of biofilm formation through the pel locus and suggest PA3885 should be named TpbA for tyrosine phosphatase related to biofilm formation and PA1120 should be TpbB.
  92. pmc FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST
    Yanhua Zheng
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 35:11-25. 2009
    ..We demonstrate here that activated Ras induces tyrosine dephosphorylation and inhibition of FAK mediated by the Ras downstream Fgd1-Cdc42-PAK1-MEK-ERK signaling cascade...
  93. doi Wnt11/5a complex formation caused by tyrosine sulfation increases canonical signaling activity
    Sang wook Cha
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Curr Biol 19:1573-80. 2009
    ..sulfotransferase-1 (TPST-1) is required for Xenopus dorsal axis formation and that O-sulfation of specific tyrosine residues is necessary for the interaction of Wnt11 with Wnt5a and for enhanced canonical signaling activity...
  94. pmc Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation
    Li Chen
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 119:3257-65. 2009
    ..Here we report that alpha-synuclein is also phosphorylated at tyrosine 125 in transgenic Drosophila expressing wild-type human alpha-synuclein and that this tyrosine phosphorylation ..
  95. doi High cholesterol content and decreased membrane fluidity in human spermatozoa are associated with protein tyrosine phosphorylation and functional deficiencies
    Mariano G Buffone
    University of Pennsylvania, Center for Research on Reproduction and Women s Health, Philadelphia, Pennsylvania, USA
    J Androl 30:552-8. 2009
    Poor-quality sperm show reduced capacity to undergo capacitation-induced protein tyrosine phosphorylation and hyperactivation...
  96. doi PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect
    Chi V Dang
    Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Sci Signal 2:pe75. 2009
    New evidence suggests that the receptor tyrosine kinase FGFR1 (fibroblast growth factor receptor 1) directly phosphorylates pyruvate kinase M2 (PKM2), resulting in reduced conversion of phosphoenolpyruvate to pyruvate, which is further ..
  97. doi STAT3 tyrosine phosphorylation influences survival in glioblastoma
    Peter Birner
    Institute of Neurology, Medical University of Vienna, Vienna, Austria
    J Neurooncol 100:339-43. 2010
    ..In sum, our results suggest that STAT3 inhibition should be considered as a therapeutic approach in malignant gliomas...
  98. ncbi Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    Z Wen
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021 6399, USA
    Cell 82:241-50. 1995
    Stat1 and Stat3 are latent transcriptional factors activated initially through phosphorylation on single tyrosine residues induced by cytokine and growth factor occupation of cell surface receptors...
  99. ncbi Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
    D D Schlaepfer
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Nature 372:786-91. 1994
    The cytoplasmic focal adhesion protein-tyrosine kinase (FAK) localizes with surface integrin receptors at sites where cells attach to the extracellular matrix...
  100. ncbi Anaplasma phagocytophilum AnkA secreted by type IV secretion system is tyrosine phosphorylated by Abl-1 to facilitate infection
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
    Cell Microbiol 9:2644-57. 2007
    ..A. phagocytophilum specifically induces tyrosine phosphorylation of a 160 kDa protein (P160) in host cells...
  101. doi Src-Tyrosine kinases are major agents in mitochondrial tyrosine phosphorylation
    Elena Tibaldi
    Dipartimento di Chimica Biologica, Universita di Padova, Istituto di Neuroscienze del C N R, Via G Colombo 3, 35121 Padova, Italy
    J Cell Biochem 104:840-9. 2008
    Mitochondrial tyrosine phosphorylation is emerging as an important mechanism in regulating mitochondrial function...

Research Grants73

  1. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..These mice are immunodeficient and also deficient in the tyrosine catabolic enzyme, fumarylacetoacetate hydrolase (Fah -/-) and develop irreversible liver failure if left ..
  2. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..The brain makes dopamine from tyrosine, an amino acid present in the normal diet...
  3. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..research, we plan to use mass spectroscopy and other novel techniques to investigate site specific Ser and tyrosine (Tyr) phosphorylation of IRS-1 in relation to Ang II and aldosterone induced insulin resistance...
  4. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..complex consisting of LRP4, a low-density lipoprotein receptor-related protein, and MuSK, a muscle-specific tyrosine kinase...
  5. CLIFFORD RUSSELL GREYSON; Fiscal Year: 2016
    ..direct phosphorylation by the extracellular response kinase ERK, or by phosphorylation of calpain targets by the tyrosine kinase src...
  6. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..Interestingly, BCR, but not SDF-11 stimulation induces robust phosphorylation of ezrin on unique tyrosine residues suggesting that ezrin participates in signal transduction downstream of BCR ligation...
  7. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..2. Explore in vitro the mechanism(s) for desensitization of human mast cells involving Src and/or Syk tyrosine kinases. Although Syk depletion seems likely, the involvement of Lyn and/or Fyn is uncertain...
  8. Michael Demetriou; Fiscal Year: 2014
    ..This inhibits basal signaling by the Src tyrosine kinase Lck and TCR clustering and signaling at the immune synapse...
  9. Mitchell Kronenberg; Fiscal Year: 2014
    ..Cbl-b is composed of an N-terminal tyrosine kinase binding domain, a RING finger, and C-terminal proline-rich sequences...
  10. Maria Diakonova; Fiscal Year: 2014
    ..These results suggest the need for a more complete understanding of PRLR signaling in breast cancer. Tyrosine (Tyr) kinase JAK2 was identified as a PRLR-bound signaling molecule...
  11. ANIL KUMAR JAISWAL; Fiscal Year: 2014
    ..INrf2 from antioxidant untreated and treated cells demonstrated phosphorylation of specific serine, threonine and tyrosine residues that might control INrf2 functions but remains unknown...
  12. Protein Nitration in the Placenta
    Leslie Myatt; Fiscal Year: 2012
    Nitration of protein tyrosine residues by the pro-oxidant peroxynitrite is a prevalent, functionally significant post- translation modification leading to either a gain or loss of protein function and alterations in cellular activity...
  13. Petr Tvrdik; Fiscal Year: 2014
    ..explore the potential of using an alternative site-specific recombination system in the mouse, based on Dre, a tyrosine recombinase similar to Cre but possessing a distinct DNA specificity...
  14. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..MPO also oxidizes aromatic amino acids such as tyrosine and tryptophan to generate cytotoxic tyrosyl and tryptophanyl radicals...
  15. Subhash C Pandey; Fiscal Year: 2014
    ..Binding of BDNF to tyrosine kinase B receptors triggers the activation of the mitogen-activated protein (MAP) kinase signaling pathway, which ..
  16. Diane Lebesgue; Fiscal Year: 2014
    ..Aim 1 will use double-label immunocytochemistry for GPR30 and tyrosine hydroxylase, a marker of dopamine neurons, combined with retrograde tract tracing to identify the neuroanatomical ..
  17. Christie P Thomas; Fiscal Year: 2014
    ..and hypertension frequently seen in patients undergoing chemotherapy with anti-VEGF monoclonal antibodies or with tyrosine kinase inhibitors and provides a model to study the role of VEGF and its receptors in glomerular endothelial cell ..
  18. Functional Analysis of the Dual Specificity Kinase NEK1 in Mammalian Meiosis
    JOANNA KIM HOLLOWAY; Fiscal Year: 2011
    ..NEK1 is a dual activity serine/threonine and tyrosine kinase, and is highly expressed in germ cells, particularly the narrow window encompassing the entry into, and ..
  19. Clifford A Lowell; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The Src-family tyrosine kinases play pivotal roles in initiating intracellular signaling from a diverse repertoire of receptors on innate immune leukocytes...
  20. The genetics and pathophysiology of impaired Wnt signaling in metabolic syndrome
    Arya Mani; Fiscal Year: 2012
    ..GSK3 inhibits glycogen synthase activity by phosphorylation of its serine/tyrosine residues...
  21. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..b>Tyrosine kinase inhibitors (TKI) that target Bcr-abl (the CML oncogene) induce remission in the majority of patients...
  22. Iris Z Jaffe; Fiscal Year: 2016
    ..cell proliferation, monocyte chemotaxis, and inflammation by binding to the transmembrane receptor, fms-like tyrosine kinase (Flt-1)...
  23. David E Clapham; Fiscal Year: 2014
    ..by these proteins are activated or potentiated by phospholipase C via subtypes of G protein-coupled receptors and tyrosine kinase receptors...
  24. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..It has been clearly demonstrated that the long isoform of LepRs mediates cell signaling via the JAK family of tyrosine kinases and subsequent phosphorylation of STAT3...
  25. Subhash C Pandey; Fiscal Year: 2016
    ..It is also unknown how the expression of Arc and various exons of BDNF and its receptor, tyrosine kinase B (trkB)-linked signaling [cAMP responsive-element binding protein (CREB) and extracellular regulated ..
  26. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..tracheal system is controlled by patterned interactions between a fibroblast growth factor (FGF) receptor tyrosine kinase (TK) ortholog, Breathless (Btl), and its FGF ligand, Branchless (Bnl)...
  27. MOLECULAR BIOLOGY OF HUMAN COAGULATION FACTOR V
    Thomas Ortel; Fiscal Year: 2010
    ..b>Tyrosine and leucine residues located in an analogous location within the homologous factor V C1 domain play a role in ..
  28. Gary B Kaplan; Fiscal Year: 2014
    ..Our aims will examine the BDNF and neurotrophic tyrosine kinase receptor (TrkB) receptor mechanisms in mesolimbic dopamine and prefrontal cortical neurons during COR and ..
  29. JAMES RUSSELL SOWERS; Fiscal Year: 2016
    ..b>tyrosine (p) and the resultant downstream IRS-1/PI3-K/Akt signaling.
  30. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..In this regard, recent studies showed that targeted over-expression of a structurally unique osteoclastic protein-tyrosine phosphatase (PTP-oc) in osteoclastic cells led to a large increase in bone resorption and a marked decrease in ..
  31. Moosa Mohammadi; Fiscal Year: 2016
    ..The diverse activities of FGFs are transmitted by the FGF receptor (FGFR) subfamily of receptor tyrosine kinases (RTKs)...
  32. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
    ..This project will have direct clinical application since the identification of deregulated oncogenic protein tyrosine kinases (PTK) leading to PTHrP overexpression will facilitate identification of potent and specific PTK ..
  33. Jean F Regal; Fiscal Year: 2015
    ..autoantibodies to angiotensin II type I receptor (AT1-AA) and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 despite the observation that many women do not present with increases in either...
  34. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ..of NOX5 by hydrogen peroxide (H2O2) acting through a signaling pathway involving calcium and the non-receptor tyrosine kinase c-Abl...
  35. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Quentin J Baca; Fiscal Year: 2010
    ..Specifically, we will examine the mobility control mechanisms and molecular associations of the receptor-like tyrosine phosphatase CD45, a key regulator of T cell activation...
  36. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
    ..Several tumors from this collection aberrantly expressed ret tyrosine kinase transcripts due to a ret/PTC1 or ret/PTC3 chromosomal rearrangements involving chromosome 10...
  37. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..We identified a small molecule receptor tyrosine kinase inhibitor with activity against both PDGFR and KDR...
  38. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..GFLs activate receptor tyrosine kinase Ret in nociceptors and a subset of low threshold mechanoreceptors...
  39. CLIFFORD JAMES ROSEN; Fiscal Year: 2015
    ..Dock7 is phosphorylated by ErbB2 a tyrosine kinase receptor that heterodimerizes with other ErbB receptors to enhance cell proliferation through the MAPK and ..
  40. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..In aim IV We will determine 1) the effect of Ac-SDKP on the non-receptor tyrosine kinase Src and HB-EGF on Ang II and ET-1-stimulated transactivation of the EGFR;2) whether Ac-SDKP inhibits the ..
  41. Robert F Foronjy; Fiscal Year: 2014
    ..PP2A activity is decreased by tyrosine phosphorylation of Tyr307 and disulfide cross-linking of the catalytic (C) subunit of the enzyme which are ..
  42. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..Previously, we studied how the AT1R increases tyrosine phosphorylation since tyrosine kinase pathways are closely related to pathogenic events such as VSMC ..
  43. Molecular Pathogenesis of MDS and CMML
    Jaroslaw P Maciejewski; Fiscal Year: 2013
    ..We will perform in vitro studies to delineate the effect of c-Cbl mutations on tyrosine kinase receptors and Src family kinases and explain whether pathologic mechanisms are mediated by mutant c-Cbl...
  44. Mario Strazzabosco; Fiscal Year: 2016
    ..The increased activation of NF-?B was prevented by inhibition of TLR4. We also found that the activity of Src, a tyrosine kinase involved in cell response to LPS, was upregulated in CF cells and resulted in an increased phosphorylation ..
  45. Hamid I Akbarali; Fiscal Year: 2014
    ..test the hypothesis that reactive nitrogen species produced during colonic inflammation cause nitration of the tyrosine residues within the c-terminus of the calcium channel and result in down-regulation of channel function...
  46. Lih Yun Hsu; Fiscal Year: 2016
    ..Weiss'laboratory as a postdoctoral scholar, I initiated a project aimed at definin the in vivo role of tyrosine 315 and 319 of ZAP-70 in regulating ZAP-70 function by generating a ZAP-70 knock-in mouse, the YYAA mouse...
  47. Jay R Winkler; Fiscal Year: 2016
    ..program, the molecular parameters that control multistep electron tunneling through tryptophan (Aim 1) and tyrosine (Aim 2) radicals will be examined...
  48. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
    ..involves the ephrin-A3 ligand expressed on the surface of astrocytes in the hippocampus and the EphA4 receptor tyrosine kinase expressed on dendritic spines...
  49. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..We have isolated a novel milk peptide mixture (AX-3) that inhibits the tyrosine kinase activity of epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor 2 (VEGFR2)..
  50. PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN
    CYNTHIA SEARS; Fiscal Year: 2010
    ..and triggers the activation of multiple signal transduction pathways including beta-catenin, gamma-secretase, tyrosine kinases, Nuclear Factor-kB (NF-kB) and mitogen-activated protein kinases (MARK) resulting in c-Myc induction, IEC ..
  51. TSAD AS AN EPOR/JAK2 ADAPTOR AND ERYTHROPOIETIC REGULATOR
    DONALD JOSEPH MCCRANN; Fiscal Year: 2010
    ..Downstream signaling pathways are then stimulated, in part via 8 phospho- tyrosine (PY) docking sites in the EPOR cytoplasmic region...
  52. MECHANISM OF DRUG TRANSPORT IN LUNG CANCER CELLS
    Sanjay Awasthi; Fiscal Year: 2011
    ..following three areas: 1) In-vivo studies of efficacy, target specificity, and toxicity, 2) Regulation of Rlip by PKC alpha and tyrosine kinases, and 3) Regulation by signaling proteins including POB1 and cdc2 involved in endocytosis.
  53. Fic-mediated Adenylylation
    CAROLYN ANN WORBY; Fiscal Year: 2013
    ..signaling of these GTPases by using ATP to catalyze the covalent addition of adenosine monophosphate (AMP) to a tyrosine (Tyr) residue in the GTPase switch I region...
  54. JULIAN G CAMBRONERO; Fiscal Year: 2016
    ..The hypothesis is that PLD2 GEF activity is regulated by tyrosine phosphorylation and by interaction with PDZ domain proteins, which lead to PX and PH domains of PLD2 and ..
  55. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    The EphA4 receptor tyrosine kinase is highly expressed in the developing and adult nervous system, and is upregulated following nervous system injury. A number of important functions have been ascribed to this receptor in neural cells...
  56. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ..Specifically, expression of fms-like tyrosine kinase 3 ligand (Flt3L) recruits antigen presenting cells (e.g...
  57. Ann Arvin; Fiscal Year: 2016
    ..This is based on our new evidence that preventing tyrosine phosphorylation of the gB cytoplasmic domain (gBcyt) leads to anomalies in cell-cell fusion and syncytia ..
  58. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    ..Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is activated by integrins and hypothesized to regulate aspects of cell survival and motility during ..
  59. Testing the efficacy of PGC-1alpha as a therapeutic target for Parkinson's diseas
    HANS BUELER; Fiscal Year: 2010
    ..hemisphere;and (3) whether viral-mediated expression of PGC-1a in dopamine neurons reduces overall protein nitration in the SNc and nitration of tyrosine hydroxylase and 1-synuclein in the striatum of MPTP-treated mice.
  60. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2012
    ..In a counterpoint to the prosurvival activity mediated by activation of CK2, CD5 also has an immunoreceptor tyrosine inhibitory motif (ITIM) necessary for negative regulation of B-cell activation...
  61. JAMES ALAN SHAYMAN; Fiscal Year: 2014
    ..Examples include the milk fat globule-EGF factor 8 and the c-mer proto-oncogene tyrosine kinase...
  62. Jordan A Kreidberg; Fiscal Year: 2014
    ..We have also demonstrated that the receptor tyrosine kinase c-Met requires interaction with 31 integrin for maximal activation in response to its ligand, HGF...
  63. C-FES PROTEIN-TYROSINE KINASE IN MYELOID DIFFERENTIATION
    Robert Glazer; Fiscal Year: 1993
    The purpose of this proposal is to determine how a myeloid-specific proto- oncogene protein-tyrosine kinase, c-fes can regulate the differentiation of myeloid leukemia cells...
  64. Tyrosine Sulfation and Chemokine Receptor Function
    Kevin Moore; Fiscal Year: 2006
    b>Tyrosine sulfation is a post-translational modification mediated by one of two Golgi tyrosylprotein sulfotransferases (TPST-1 and TPST-2), that catalyze the transfer of sulfate from PAPS to lumenally oriented tyrosine residues in secreted ..
  65. Molecular genetic analysis of tyrosine kinases in myeloproliferative disorders
    Ross L Levine; Fiscal Year: 2010
    ..We hypothesize that PV, ET and AMM are due to activating mutations in tyrosine kinases...
  66. TYROSINE PHOSPHORYLATION AT THE NEUROMUSCULAR JUNCTION
    Richard Huganir; Fiscal Year: 1999
    ..Protein tyrosine kinases, a unique class of protein kinases that exclusively phosphorylate tyrosine residues of their substrate ..
  67. Signaling by a Tyrosine-Deficient IL-2/15 Receptor Beta
    SARAH GAFFEN; Fiscal Year: 2001
    ..In particular, this work will focus on signals that are delivered by a "tyrosine-deficient" IL-2/l5R...
  68. TYROSINE PHOSPHORYLATION AND MAMMALIAN RETINA
    ABBOUD GHALAYINI; Fiscal Year: 2001
    Signaling through intracellular tyrosine phosphorylation is an integral component of many normal and aberrant cellular processes including growth, differentiation, proliferation, maintenance and survival...
  69. Dynamin Function by Tyrosine Phoshorylation
    Yehia Daaka; Fiscal Year: 2005
    ..Endocytosis of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) is dependent on the invagination and fission of clathrin coated vesicles from the plasma membrane ..
  70. FUNCTIONAL DISSECTION OF CBLS TRANSFORMING DOMAIN
    Hamid Band; Fiscal Year: 2002
    DESCRIPTION: (From PI's description) Tyrosine phosphorylation provides a universal mechanism of signal transmission in response to extracellular cues that regulate proliferation and differentiation in normal cells...