phosphocreatine

Summary

Summary: An endogenous substance found mainly in skeletal muscle of vertebrates. It has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1996)

Top Publications

  1. ncbi Creatine kinase in non-muscle tissues and cells
    T Wallimann
    Institute for Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich
    Mol Cell Biochem 133:193-220. 1994
  2. ncbi Repeated-sprint ability - part I: factors contributing to fatigue
    Olivier Girard
    Aspetar Qatar Orthopaedic and Sports Medicine Hospital, Research and Education Centre, Doha, Qatar
    Sports Med 41:673-94. 2011
  3. ncbi Repeated-sprint ability - part II: recommendations for training
    David Bishop
    Institute of Sport, Exercise and Active Living ISEAL, School of Sport and Exercise Science, Victoria University, Melbourne, Vic, Australia
    Sports Med 41:741-56. 2011
  4. ncbi Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy
    S Neubauer
    Department of Medicine, Wurzburg University, Germany
    Circulation 96:2190-6. 1997
  5. ncbi Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review
    Graham J Kemp
    Division of Metabolic and Cellular Medicine, Faculty of Medicine, University of Liverpool, Liverpool, UK
    NMR Biomed 20:555-65. 2007
  6. ncbi Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity
    Laudiene Evangelista Meyer
    Instituto de Bioquimica Medica, Programa de Biofísica e Bioquímica Celular and Programa de Biologia Molecular e Biotecnologia
    J Biol Chem 281:37361-71. 2006
  7. pmc Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis
    Dhaval P Bhatt
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Neurochem Int 62:296-305. 2013
  8. ncbi Metabolism of preconditioned myocardium: effect of loss and reinstatement of cardioprotection
    R B Jennings
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Mol Cell Cardiol 33:1571-88. 2001
  9. ncbi Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders
    Taro Endo
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Science, Niigata City, Niigata, Japan
    Biol Psychiatry 62:1030-7. 2007
  10. ncbi A novel relationship between creatine transport at the blood-brain and blood-retinal barriers, creatine biosynthesis, and its use for brain and retinal energy homeostasis
    Masanori Tachikawa
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan
    Subcell Biochem 46:83-98. 2007

Detail Information

Publications258 found, 100 shown here

  1. ncbi Creatine kinase in non-muscle tissues and cells
    T Wallimann
    Institute for Cell Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich
    Mol Cell Biochem 133:193-220. 1994
    ..Most interesting in this respect is the observed upregulation of CK expression by adenoviral oncogenes...
  2. ncbi Repeated-sprint ability - part I: factors contributing to fatigue
    Olivier Girard
    Aspetar Qatar Orthopaedic and Sports Medicine Hospital, Research and Education Centre, Doha, Qatar
    Sports Med 41:673-94. 2011
    ..At the muscle level, limitations in energy supply, which include energy available from phosphocreatine hydrolysis, anaerobic glycolysis and oxidative metabolism, and the intramuscular accumulation of metabolic by-..
  3. ncbi Repeated-sprint ability - part II: recommendations for training
    David Bishop
    Institute of Sport, Exercise and Active Living ISEAL, School of Sport and Exercise Science, Victoria University, Melbourne, Vic, Australia
    Sports Med 41:741-56. 2011
    ..g. oxidative capacity, phosphocreatine recovery and H+ buffering) and neural factors (e.g...
  4. ncbi Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy
    S Neubauer
    Department of Medicine, Wurzburg University, Germany
    Circulation 96:2190-6. 1997
    ..dilated cardiomyopathy, cardiac energy metabolism is impaired, as indicated by a reduction of the myocardial phosphocreatine-to-ATP ratio, measured noninvasively by 31P-MR spectroscopy...
  5. ncbi Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review
    Graham J Kemp
    Division of Metabolic and Cellular Medicine, Faculty of Medicine, University of Liverpool, Liverpool, UK
    NMR Biomed 20:555-65. 2007
    ..Inter-study correlation of estimates of [Pi] and [phosphocreatine (PCr)] in a number of published studies suggest that the main technical problem in calibrated 31P MRS studies ..
  6. ncbi Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity
    Laudiene Evangelista Meyer
    Instituto de Bioquimica Medica, Programa de Biofísica e Bioquímica Celular and Programa de Biologia Molecular e Biotecnologia
    J Biol Chem 281:37361-71. 2006
    ..The extension of the preventive antioxidant role of mt-CK depended on the phosphocreatine (PCr)/Cr ratio...
  7. pmc Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis
    Dhaval P Bhatt
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    Neurochem Int 62:296-305. 2013
    ..However, after 4h of treatment brain phosphocreatine levels were significantly elevated with a concomitant reduction in AMP levels with no change in glycogen ..
  8. ncbi Metabolism of preconditioned myocardium: effect of loss and reinstatement of cardioprotection
    R B Jennings
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Mol Cell Cardiol 33:1571-88. 2001
    ..However, the mechanism through which ischemic preconditioning results in lower energy demand remains to be established...
  9. ncbi Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders
    Taro Endo
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Science, Niigata City, Niigata, Japan
    Biol Psychiatry 62:1030-7. 2007
    ..The objective of the present study was to determine whether individuals with ASD have altered brain chemical metabolites and whether such alterations are related to their autistic symptoms...
  10. ncbi A novel relationship between creatine transport at the blood-brain and blood-retinal barriers, creatine biosynthesis, and its use for brain and retinal energy homeostasis
    Masanori Tachikawa
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan
    Subcell Biochem 46:83-98. 2007
    Evidence is increasing that the creatine/phosphocreatine shuttle system plays an essential role in energy homeostasis in the brain and retina to ensure proper development and function...
  11. ncbi Phosphocreatine and ATP content in human single muscle fibres before and after maximum dynamic exercise
    C Karatzaferi
    Neuromuscular Biology Research Group, Manchester Metropolitan University, UK
    Pflugers Arch 442:467-74. 2001
    ..Fibres were analysed for adenosine 5'-triphosphate (ATP), inosine-5'-monophosphate (IMP), phosphocreatine (PCr) and creatine (Cr) levels. Type I fibres had a lower Cr content than type II fibres (P<0.01)...
  12. ncbi Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons
    G J Brewer
    Department of Medical Microbiology Immunology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9626, USA
    J Neurochem 74:1968-78. 2000
    ..We hypothesize that cells supplemented with the precursor creatine make more phosphocreatine (PCr) and create larger energy reserves with consequent neuroprotection against stressors...
  13. ncbi Live high:train low increases muscle buffer capacity and submaximal cycling efficiency
    C J Gore
    Australian Institute of Sport, Adelaide, South Australia, Australia
    Acta Physiol Scand 173:275-86. 2001
    ..This is the first study to show that hypoxic exposure, per se, increases muscle buffer capacity. Further, reduced VO2 during normoxic exercise after LHTL suggests that improved exercise efficiency is a fundamental adaptation to LHTL...
  14. ncbi Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice
    Ronglih Liao
    Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 106:2125-31. 2002
    ..Although these changes have been considered part of the fetal gene reactivation program, the functional significance of increased glucose utilization in hypertrophied and failing myocardium is poorly understood...
  15. ncbi In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism
    Lisa A Page
    Section of Brain Maturation, Institute of Psychiatry, London
    Am J Psychiatry 163:2189-92. 2006
    ..However, the concentration of glutamate/glutamine in brain regions implicated in autistic spectrum disorders has not yet been examined in vivo...
  16. ncbi Short-term high-intensity interval training improves phosphocreatine recovery kinetics following moderate-intensity exercise in humans
    Sean C Forbes
    Department of Physiology, Michigan State University, East Landing, MI 48824, USA
    Appl Physiol Nutr Metab 33:1124-31. 2008
    ..study was to examine the effect of short-term high-intensity interval training on the time constant () of phosphocreatine (PCr) recovery following moderate-intensity exercise, an in vivo measure of functional oxidative capacity...
  17. ncbi Effect of two different intense training regimens on skeletal muscle ion transport proteins and fatigue development
    Magni Mohr
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 292:R1594-602. 2007
    ..Adaptations with training do have an effect on the metabolic response to exercise and specific improvement in work capacity...
  18. ncbi Phosphorus-31 two-dimensional chemical shift imaging in the myocardium of patients with late onset of Friedreich ataxia
    Christian Wolf
    Department of Radiology I, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Mol Imaging Biol 10:24-9. 2008
    ..The purpose of this study was to investigate cardiac function and high-energy phosphate metabolism in FRDA patients with late disease onset...
  19. ncbi Metabolism and performance in repeated cycle sprints: active versus passive recovery
    Matt Spencer
    Team Sport Research Group, School of Human Movement and Exercise Science, The University of Western Australia, Crawley, Australia
    Med Sci Sports Exerc 38:1492-9. 2006
    ..To compare active versus passive recovery on performance and metabolism during a test of repeated-sprint ability...
  20. ncbi Effects of high-intensity training on muscle lactate transporters and postexercise recovery of muscle lactate and hydrogen ions in women
    David Bishop
    School of Human Movement and Exercise Science, The University of Western Australia, Crawley, Western Australia, Australia
    Am J Physiol Regul Integr Comp Physiol 295:R1991-8. 2008
    ..Muscle samples were analyzed for ATP, phosphocreatine (PCr), lactate, and H+; MCT1 and MCT4 relative abundance and betam(in vitro) were also determined in resting ..
  21. pmc Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects
    Malgorzata Tokarska-Schlattner
    University Joseph Fourier, Laboratory of Fundamental and Applied Bioenergetics, Grenoble, France
    PLoS ONE 7:e43178. 2012
    A broad spectrum of beneficial effects has been ascribed to creatine (Cr), phosphocreatine (PCr) and their cyclic analogues cyclo-(cCr) and phospho-cyclocreatine (PcCr)...
  22. ncbi Asperger syndrome: a proton magnetic resonance spectroscopy study of brain
    Declan G M Murphy
    Department of Psychological Medicine, St George s Hospital Medical School, London, England
    Arch Gen Psychiatry 59:885-91. 2002
    ..Nobody has examined the relationship between abnormalities in the frontal and parietal lobes and clinical symptoms in people with AS...
  23. ncbi Influence of hyperoxia on muscle metabolic responses and the power-duration relationship during severe-intensity exercise in humans: a 31P magnetic resonance spectroscopy study
    Anni Vanhatalo
    School of Sport and Health Sciences, St Luke s Campus, University of Exeter, Exeter EX1 2LU, UK
    Exp Physiol 95:528-40. 2010
    ..severe-intensity exercise would be associated with the attainment of consistently low values of intramuscular phosphocreatine ([PCr]) and pH, as determined using (31)P magnetic resonance spectroscopy, irrespective of the work rate and ..
  24. ncbi Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma
    Subrata Patra
    Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India
    FEBS J 275:3236-47. 2008
    In vertebrates, phosphocreatine and ATP are continuously interconverted by the reversible reaction of creatine kinase in accordance with cellular energy needs...
  25. ncbi Structural and functional determinants of human muscle power
    Anthony J Sargeant
    Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Hassall Road, Alsager, Cheshire ST7 2HL, UK
    Exp Physiol 92:323-31. 2007
    ..The microdissection technique can also be used to measure phosphocreatine concentration ([PCr]), which is an exquisitely sensitive indicator of muscle fibre activity; thus, in just ..
  26. pmc Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger's disorder
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
    J Autism Dev Disord 39:1079-86. 2009
    ..Magnetic resonance spectroscopy was used to measure N-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala...
  27. ncbi Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure
    Gabriele Fragasso
    Department of Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico Universita San Raffaele, Via Olgettina 60, 20132 Milano, Italy
    Eur Heart J 27:942-8. 2006
    ..study is to non-invasively assess, by means of in vivo 31P-magnetic resonance spectroscopy (31P-MRS), the effects of trimetazidine on LV cardiac phosphocreatine and adenosine triphosphate (PCr/ATP) ratio in patients with heart failure.
  28. ncbi Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian cells via direct antioxidant activity
    Piero Sestili
    Istituto di Ricerca sull Attività Motoria, Universita degli Studi di Urbino Carlo Bo, Italy
    Free Radic Biol Med 40:837-49. 2006
    ..In conclusion, it is suggested that Cr exerts a mild, although significant, antioxidant activity in living cells, via a mechanism depending on direct scavenging of reactive oxygen (in particular hydroxyl radical) and nitrogen species...
  29. pmc Mitochondrial dysfunction in patients with primary congenital insulin resistance
    Alison Sleigh
    Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom
    J Clin Invest 121:2457-61. 2011
    ..We found that phosphocreatine recovery after exercise, a measure of skeletal muscle mitochondrial function in vivo, was significantly ..
  30. ncbi Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage
    Javier Inserte
    Servicio de Cardiologia, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, Barcelona, Spain
    Cardiovasc Res 77:782-90. 2008
    ..However, contradictory reports exist on the effects of acidic reperfusion on myocardial salvage. Here we characterized the effect of lowering the pH of the reperfusion media (pHo) on intracellular pH (pHi) and cell death...
  31. pmc Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases
    Peter J Adhihetty
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Neuromolecular Med 10:275-90. 2008
    ..into cells, creatine kinase catalyzes the reversible transphosphorylation of creatine via ATP to enhance the phosphocreatine energy pool...
  32. ncbi Phosphocreatine restores high-energy phosphates in ischemic myocardium: implication for off-pump cardiac revascularization
    Ganga Prabhakar
    West Virginia University, Department of Surgery, Morgantown, WV 26506 9238, USA
    J Am Coll Surg 197:786-91. 2003
    High-energy phosphate metabolism is altered in the ischemic myocardium. We investigated the effects of in vivo administration of phosphocreatine (PCr) in a transient ischemic rat model to emulate off-pump myocardial revascularization.
  33. ncbi Influence of dietary creatine supplementation on muscle phosphocreatine kinetics during knee-extensor exercise in humans
    Andrew M Jones
    University of Exeter, Exeter, Devon EX1 2 LU, UK
    Am J Physiol Regul Integr Comp Physiol 296:R1078-87. 2009
    ..skeletal muscle total creatine (Cr) content through dietary Cr supplementation would result in slower muscle phosphocreatine concentration ([PCr]) kinetics, as assessed using (31)P magnetic resonance spectroscopy, following the onset ..
  34. ncbi Human muscle performance and PCr hydrolysis with varied inspired oxygen fractions: a 31P-MRS study
    M C Hogan
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 86:1367-73. 1999
    ..05) greater as FIO2 was increased. Muscle phosphocreatine (PCr) concentration, Pi concentration, and pH at exhaustion were not significantly different among the three ..
  35. ncbi Recruitment of fibre types and quadriceps muscle portions during repeated, intense knee-extensor exercise in humans
    Peter Krustrup
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen O, Denmark
    Pflugers Arch 449:56-65. 2004
    ....
  36. ncbi 31P MRS measurement of mitochondrial function in skeletal muscle: reliability, force-level sensitivity and relation to whole body maximal oxygen uptake
    D E Larson-Meyer
    Department of Nutrition Sciences, Division of Physiology and Metabolism, The University of Alabama at Birmingham, Birmingham, AL 35205, USA
    NMR Biomed 13:14-27. 2000
    ..70 and 100% of maximum voluntary contraction, skeletal muscle mitochondrial function was determined from the phosphocreatine recovery time constant (TC(PCr)), the ADP recovery time constant (TC(ADP)), and the rate of change in PCr ..
  37. ncbi Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: mitochondrial interactosome
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
    Biochim Biophys Acta 1797:678-97. 2010
    ..ATP synthasome amplifies this signal by recycling adenine nucleotides in mitochondria coupled to effective phosphocreatine synthesis...
  38. ncbi Intersubject differences in the effect of acidosis on phosphocreatine recovery kinetics in muscle after exercise are due to differences in proton efflux rates
    Nicole M A van den Broek
    Biomedical NMR, Dept of Biomedical Engineering, Eindhoven University of Technology, N laag b1 08, PO Box 513, 5600 MB Eindhoven, The Netherlands
    Am J Physiol Cell Physiol 293:C228-37. 2007
    ..The time constant of phosphocreatine (PCr) recovery (tau(PCr)) has been used as a measure of mitochondrial function...
  39. pmc The creatine kinase system and pleiotropic effects of creatine
    Theo Wallimann
    Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    Amino Acids 40:1271-96. 2011
    ..Cr) are based mostly on the functions of the enzyme creatine kinase (CK) and its high-energy product phosphocreatine (PCr)...
  40. ncbi Is the failing heart energy starved? On using chemical energy to support cardiac function
    Joanne S Ingwall
    Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Res 95:135-45. 2004
    ..We present an analysis of what is now known about the causes and consequences of these energetic changes and conclude by commenting on unsolved problems and opportunities for future basic and clinical research...
  41. ncbi Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage
    M Balestrino
    Department of Neurological and Vision Sciences, University of Genova, Italy
    Amino Acids 23:221-9. 2002
    b>Phosphocreatine can to some extent compensate for the lack of ATP synthesis that is caused in the brain by deprivation of oxygen or glucose...
  42. ncbi Effects of recovery time on phosphocreatine kinetics during repeated bouts of heavy-intensity exercise
    S C Forbes
    School of Kinesiology, The University of Western Ontario, London, Ontario, Canada
    Eur J Appl Physiol 103:665-75. 2008
    The purpose of this study was to examine the kinetics of phosphocreatine (PCr) breakdown in repeated bouts of heavy-intensity exercise separated by three different durations of resting recovery...
  43. ncbi Kinetics of creatine in blood and brain after intraperitoneal injection in the rat
    Luisa Perasso
    Dipartimento di Neuroscienze, Oftalmologia e Genetica, Universita di Genova, Via De Toni 5, Italy
    Brain Res 974:37-42. 2003
    ..liquid chromatography in the brain levels of either this compound or its phosphorylated derivative, phosphocreatine. Although our data clearly show some passage of serum creatine into the brain, other strategies are needed to ..
  44. ncbi Control of glycolysis in contracting skeletal muscle. II. Turning it off
    Gregory J Crowther
    Department of Physiology and Biophysics, University of Washington Medical Center, Seattle, Washington 98195 7115, USA
    Am J Physiol Endocrinol Metab 282:E74-9. 2002
    ..Glycolytic H(+) and ATP production were quantified from changes in muscle pH, phosphocreatine concentration, and P(i) concentration as measured by 31P magnetic resonance spectroscopy...
  45. pmc AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    Haihong Zong
    Howard Hughes Medical Institute and the Departments of Internal Medicine, Cell Biology, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:15983-7. 2002
    ..acid (GPA), a creatine analog, which led to similar reductions in the intramuscular ATPAMP ratio and phosphocreatine concentrations. In WT mice, GPA treatment resulted in activation of muscle AMPK and mitochondrial biogenesis...
  46. ncbi Adenine nucleotide-creatine-phosphate module in myocardial metabolic system explains fast phase of dynamic regulation of oxidative phosphorylation
    Johannes H G M van Beek
    Dept of Molecular Cell Physiology, FALW, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam
    Am J Physiol Cell Physiol 293:C815-29. 2007
    ....
  47. ncbi Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls
    Yousha Mirza
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 21:106-11. 2006
    Altered brain creatine-phosphocreatine levels might reflect changes in brain energy use and have been implicated in the pathogenesis of obsessive-compulsive disorder and major depressive disorder...
  48. ncbi Delayed metabolic activation of oxidative phosphorylation in skeletal muscle at exercise onset
    Bruno Grassi
    Department of Science and Biomedical Technologies Università degli Studi di Milano, Italy
    Med Sci Sports Exerc 37:1567-73. 2005
    ....
  49. ncbi Dynamics of intramuscular 31P-MRS P(i) peak splitting and the slow components of PCr and O2 uptake during exercise
    H B Rossiter
    Department of Physiology, St George s Hospital Medical School, Tooting, London SW17 0RE, United Kingdom
    J Appl Physiol 93:2059-69. 2002
    ..therefore investigated the dynamics of Vo(2) (using a turbine and mass spectrometry) and intramuscular ATP, phosphocreatine (PCr), and P(i) concentrations and pH, estimated from the (31)P MR spectrum...
  50. ncbi Performance and metabolism in repeated sprint exercise: effect of recovery intensity
    Matt Spencer
    School of Human Movement and Exercise Science, The University of Western Australia, Crawley, WA, Australia
    Eur J Appl Physiol 103:545-52. 2008
    ..pre- and immediately post-test during the MI and LI trials to determine adenosine triphosphate (ATP), phosphocreatine (PCr) and lactate (MLa(-)) content. Compared to passive, significant reductions in peak power of 3.4-6...
  51. ncbi High-energy phosphate metabolism during incremental calf exercise in patients with unilaterally symptomatic peripheral arterial disease measured by phosphor 31 magnetic resonance spectroscopy
    Andreas Greiner
    Department of Surgery, Division of Vascular Surgery, Innsbruck Medical University, Innsbruck, Austria
    J Vasc Surg 43:978-86. 2006
    ..The purpose of this study was to investigate the high-energy metabolism in the calf muscle during incremental progressive plantar flexion exercise of a selected peripheral arterial disease (PAD) patient group...
  52. ncbi Exertional oxygen uptake kinetics: a stamen of stamina?
    Brian J Whipp
    Centre for Exercise Science and Medicine, University of Glasgow, Glasgow, G12 8QQ, Scotland, U K
    Biochem Soc Trans 30:237-47. 2002
    ..VO(2) kinetics reflecting intramuscular O(2) uptake (.QO(2)) kinetics, to within 10%. The role of phosphocreatine (PCr) turnover in .QO(2) control can be explored using (31)P-MR spectroscopy, simultaneously with .VO(2)...
  53. pmc Spectrally selective 3D TSE imaging of phosphocreatine in the human calf muscle at 3 T
    Prodromos Parasoglou
    Quantitative Multinuclear Musculoskeletal Imaging Group, Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, New York 10016, USA
    Magn Reson Med 69:812-7. 2013
    ..spectrally selective turbo spin-echo sequence, on a 3T clinical system, to map the concentration of phosphocreatine in the human calf muscle with significantly increased spatial resolution and in a clinically feasible scan ..
  54. ncbi Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players
    Greg Cox
    Australian Institute of Sport, Department of Sports Nutrition, Australian Capital Territory, Belconnen
    Int J Sport Nutr Exerc Metab 12:33-46. 2002
    ..05). The accuracy of shooting was unaffected in both groups. In conclusion, acute Cr supplementation improved performance of some repeated sprint and agility tasks simulating soccer match play, despite an increase in BM...
  55. pmc Postexercise phosphocreatine recovery, an index of mitochondrial oxidative phosphorylation, is reduced in diabetic patients with lower extremity complications
    Francesco Tecilazich
    Joslin Beth Israel Deaconess Foot Center and Microcirculation Lab, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA
    J Vasc Surg 57:997-1005. 2013
    To identify differences in postexercise phosphocreatine (PCr) recovery, an index of mitochondrial function, in diabetic patients with and without lower extremity complications.
  56. ncbi Gray and white matter brain chemistry in young children with autism
    Seth D Friedman
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98105 6099, USA
    Arch Gen Psychiatry 63:786-94. 2006
    ..The brain pathophysiological abnormalities underlying autism remain unclear. Neuroimaging and histological studies suggest cellular abnormalities early in the course of the disease...
  57. ncbi Relaxation times of 31P-metabolites in human calf muscle at 3 T
    Martin Meyerspeer
    NMR Group, Department of Medical Physics, Vienna University, Wahringerstrasse 13, A 1090 Vienna, Austria
    Magn Reson Med 49:620-5. 2003
    ....
  58. ncbi Skeletal muscle metabolic recovery following submaximal exercise in chronic heart failure is limited more by O(2) delivery than O(2) utilization
    Hareld M C Kemps
    Department of Cardiology, Maxima Medical Centre, Veldhoven, Netherlands
    Clin Sci (Lond) 118:203-10. 2010
    ..Post-exercise PCr (phosphocreatine) resynthesis was assessed by 31P-MRS (magnetic resonance spectroscopy)...
  59. ncbi Comparison of oxidative capacity among leg muscles in humans using gated 31P 2-D chemical shift imaging
    Sean C Forbes
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    NMR Biomed 22:1063-71. 2009
    ..The purpose of this study was to compare the rate of phosphocreatine (PCr) recovery, a functional in vivo marker of oxidative capacity, in the lateral and medial gastrocnemius, ..
  60. ncbi Stimulation of mitochondrial gene expression and proliferation of mitochondria following impairment of cellular energy transfer by inhibition of the phosphocreatine circuit in rat hearts
    R J Wiesner
    Department of Physiology II, University of Heidelberg, Germany
    J Bioenerg Biomembr 31:559-67. 1999
    ..The observed activation of the mtTFA gene corroborates the important function of this protein in nuclear-mitochondrial communication...
  61. pmc Comparative expression analysis of the phosphocreatine circuit in extant primates: Implications for human brain evolution
    Adam D Pfefferle
    Biology Department, Duke University, Durham, USA Institute for Genome Sciences and Policy, Duke University, Durham, USA
    J Hum Evol 60:205-12. 2011
    ..Five phosphocreatine circuit proteins help regulate creatine utilization within energy demanding cells...
  62. ncbi High-energy phosphate metabolism during calf ergometry in patients with isolated aorto-iliac artery stenoses
    Michael F H Schocke
    Department of Radiology, Division of Vascular Surgery, Innsbruck Medical University, Innsbruck, Austria
    Invest Radiol 41:874-82. 2006
    ..The purpose of this study was to investigate the high-energy metabolism in the calf muscle of patients with PAD with isolated aorto-iliac stenoses during incremental plantar flexion exercise...
  63. ncbi Local perfusion and metabolic demand during exercise: a noninvasive MRI method of assessment
    R S Richardson
    Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0623, USA
    J Appl Physiol (1985) 91:1845-53. 2001
    ..Because phosphocreatine (PCr) depletion is directly proportional to ATP hydrolysis, its relative depletion can be used as an index of ..
  64. ncbi High-energy phosphate metabolism during two bouts of progressive calf exercise in humans measured by phosphorus-31 magnetic resonance spectroscopy
    Michael F H Schocke
    Division of Diagnostic Radiology I, Department of Radiology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Appl Physiol 93:469-79. 2005
    According to the literature the steady-state level of phosphocreatine (PCr) has a linear relationship to the workload during muscle exercise intensities below the lactate threshold, whereas this linearity is impaired during exercise ..
  65. pmc Phosphocreatine degradation in type I and type II muscle fibres during submaximal exercise in man: effect of carbohydrate ingestion
    K Tsintzas
    Human Muscle Metabolism Research Group, Loughborough University, Loughborough LE11 3TU, UK
    J Physiol 537:305-11. 2001
    1. The aim of this study was to examine the effect of carbohydrate (CHO) ingestion on changes in ATP and phosphocreatine (PCr) concentrations in different muscle fibre types during prolonged running and relate those changes to the degree ..
  66. ncbi NaHCO3-induced alkalosis reduces the phosphocreatine slow component during heavy-intensity forearm exercise
    S C Forbes
    School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7
    J Appl Physiol 99:1668-75. 2005
    During heavy-intensity exercise, the mechanisms responsible for the continued slow decline in phosphocreatine concentration ([PCr]) (PCr slow component) have not been established...
  67. ncbi Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury: metabolite peak-area ratios, relaxation times, and absolute concentrations
    J L Y Cheong
    Department of Paediatrics and Child Health, University College London, 86 96 Chenies Mews, London WC1E 6HX, UK
    AJNR Am J Neuroradiol 27:1546-54. 2006
    ....
  68. ncbi Skeletal muscle phosphocreatine recovery in exercise-trained humans is dependent on O2 availability
    L J Haseler
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    J Appl Physiol (1985) 86:2013-8. 1999
    In skeletal muscle, phosphocreatine (PCr) recovery from submaximal exercise has become a reliable and accepted measure of muscle oxidative capacity...
  69. ncbi Effects of exercise-induced intracellular acidosis on the phosphocreatine recovery kinetics: a 31P MRS study in three muscle groups in humans
    Gwenael Layec
    Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine de Marseille, Marseille, France Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, USA Geriatric Research, Education, and Clinical Center, George E Whalen VA Medical Center, Salt Lake City, UT, USA
    NMR Biomed 26:1403-11. 2013
    ....
  70. ncbi Phosphocreatine kinetics in the calf muscle of patients with bilateral symptomatic peripheral arterial disease during exhaustive incremental exercise
    Regina Esterhammer
    Department of Radiology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Mol Imaging Biol 10:30-9. 2008
    ..relationship between the atherosclerotic lesion load determined on magnetic resonance angiography (MRA) and phosphocreatine (PCr) kinetics during incremental, exhaustive calf exercise in patients with bilateral, symptomatic ..
  71. pmc Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity
    Darci Phillips
    Department of Cardiovascular Medicine, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK
    J Mol Cell Cardiol 48:582-90. 2010
    The metabolic phenotype of the failing heart includes a decrease in phosphocreatine and total creatine concentration [Cr], potentially contributing to contractile dysfunction...
  72. ncbi Influence of ischemic preconditioning on intracellular sodium, pH, and cellular energy status in isolated perfused heart
    Andriy Babsky
    Department of Radiology, 207 Anatomy Chemistry Building, University of Pennsylvania, 37th and Hamilton Walk, Philadelphia, PA 19104, USA
    Exp Biol Med (Maywood) 227:520-8. 2002
    ....
  73. pmc Dynamic asymmetry of phosphocreatine concentration and O(2) uptake between the on- and off-transients of moderate- and high-intensity exercise in humans
    H B Rossiter
    Department of Physiology, St George s Hospital Medical School, Cranmer Terrace, Tooting, London, UK
    J Physiol 541:991-1002. 2002
    ..Muscle [phosphocreatine] ([PCr]) responses to exercise, however, have been proposed to be dynamically linear with respect to work ..
  74. ncbi The mono-exponential pattern of phosphocreatine recovery after muscle exercise is a particular case of a more complex behaviour
    S Iotti
    Dipartimento di Medicina Clinica e Biotecnologia Applicata D Campanacci, Universita di Bologna, Via Massarenti, 9, 40138 Bologna, Italy
    Biochim Biophys Acta 1608:131-9. 2004
    A mathematical model is proposed showing that the mono-exponential recovery of phosphocreatine (PCr) after exercise is an approximation of a more complex pattern, which is identified by a second-order differential equation...
  75. pmc Resolution of creatine and phosphocreatine 1H signals in isolated human skeletal muscle using HR-MAS 1H NMR
    Jin Hong Chen
    Sarcoma Disease Management Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Magn Reson Med 59:1221-4. 2008
    Proton NMR spectra of freshly isolated human skeletal muscle samples contain creatine and phosphocreatine resonances with distinct chemical shifts that are easily visualized with magic angle spinning (MAS, spinning the sample rapidly at ..
  76. pmc The feasibility of measuring phosphocreatine recovery kinetics in muscle using a single-shot (31)P RARE MRI sequence
    Robert L Greenman
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Acad Radiol 18:917-23. 2011
    ..The simultaneous measurement of the postexercise phosphocreatine (PCr) recovery rate across all muscles of a human limb cross-section may provide new insights into normal ..
  77. pmc Effects of prior exercise on oxygen uptake and phosphocreatine kinetics during high-intensity knee-extension exercise in humans
    H B Rossiter
    Department of Physiology, St George's Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK
    J Physiol 537:291-303. 2001
    ..2. We therefore determined the dynamics of intramuscular [phosphocreatine] ([PCr]) simultaneously with those of ...
  78. pmc In vivo reduction in ATP cost of contraction is not related to fatigue level in stimulated rat gastrocnemius muscle
    B Giannesini
    , UMR CNRS 6612, , 27 Boulevard Jean Moulin, 13005 Marseille, France
    J Physiol 536:905-15. 2001
    ....
  79. ncbi Chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate is associated with increased mortality and loss of ATP in rats after myocardial infarction
    M Horn
    Medizinische Universitatsklinik, Wurzburg University, Germany
    Circulation 104:1844-9. 2001
    The failing myocardium is characterized by reductions of phosphocreatine (PCr) and free creatine content and by decreases of energy reserve via creatine kinase (CK), ie, CK reaction velocity (Flux(CK))...
  80. ncbi Creatine and creatine kinase in health and disease--a bright future ahead?
    Markus Wyss
    DSM Nutritional Products Ltd, Biotechnology R and D, Bldg 203 17B, P O Box 3255, CH 4002 Basel, Switzerland
    Subcell Biochem 46:309-34. 2007
    Many links are reported or suspected between the functioning of creatine, phosphocreatine, the creatine kinase isoenzymes or the creatine biosynthesis enzymes on one hand, and health or disease on the other hand...
  81. ncbi Metabolite alterations in the hippocampus of high-functioning adult subjects with autism
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Neuropsychopharmacol 13:529-34. 2010
    ..We measured concentrations of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr+PCr) in the hippocampal formation by proton magnetic resonance spectroscopy in 12 non-medicated male ..
  82. pmc Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide
    Nicole Glaser
    Department of Pediatrics, University of California, Davis, California, USA
    Diabetes 59:702-9. 2010
    ..Recent data suggest that cerebral hypoperfusion and activation of cerebral ion transporters may be involved, but data describing cerebral metabolic alterations during DKA are lacking...
  83. ncbi Luminometric assays of ATP, phosphocreatine, and creatine for estimation of free ADP and free AMP
    P Ronner
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University College of Medicine, Philadelphia, Pennsylvania 19107, USA
    Anal Biochem 275:208-16. 1999
    We present methods to measure ATP, phosphocreatine, and total creatine (the sum of creatine and phosphocreatine) in alkaline cell extracts...
  84. ncbi Aspects of human bioenergetics as studied in vivo by magnetic resonance spectroscopy
    B Barbiroli
    Dipartimento di Medicina Clinica e Biotecnologia Applicata D Campanacci, Bologna, Italy
    Biochimie 80:847-53. 1998
    ..a relevant reduction of mitochondrial functionality in the skeletal muscle as shown by the reduced rate of phosphocreatine recovery from exercise, and in the occipital lobes by reduced [phosphocreatine] and a high [ADP] and [Pi]...
  85. pmc Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction
    James A Timmons
    Department of Physiology and Pharmacology, Berzelius väg 13, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Physiol 561:851-9. 2004
    ..DCA reduced phosphocreatine (PCr) degradation by 40% during the first minute of contraction, but did not prevent the almost complete ..
  86. ncbi MR spectroscopy in heart failure
    Cameron Holloway
    Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom
    Front Biosci (Schol Ed) 3:331-40. 2011
    ..quantification of the primary energy source for all myocardial cellular functions (ATP), the energy reserve phosphocreatine (PCr), and the creatine kinase reaction, which maintains cellular energy equilibrium...
  87. ncbi Reliability of 31P-magnetic resonance spectroscopy during an exhaustive incremental exercise test in children
    Alan Barker
    Children s Health, Exercise Research Centre, St Luke s Campus, University of Exeter, Exeter, UK
    Eur J Appl Physiol 98:556-65. 2006
    ..5 T, Phillips). The dynamic changes in the ratio of inorganic phosphate to phosphocreatine (Pi/PCr) and intracellular muscle pH were resolved every 30 s...
  88. ncbi Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans
    H B Rossiter
    St George s Medical School, Department of Physiology, London SW17 ORE, United Kingdom
    J Appl Physiol 95:1105-15. 2003
    ..was measured breath by breath (by use of a turbine and mass spectrometer) simultaneously with intramuscular phosphocreatine (PCr) concentration ([PCr]), [Pi], [ATP], and pH (by 31P-MRS) and arterialized-venous blood sampling...
  89. pmc The phosphocreatine-creatine kinase system helps to shape muscle cells and keep them healthy and alive
    Valdur Saks
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, Grenoble, France
    J Physiol 586:2817-8. 2008
  90. ncbi Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function
    R Guzun
    Laboratory of Fundamental and Applied Bioenergetics, INSERM U884, Joseph Fourier University, 2280 Rue de la Piscine, Grenoble Cedex 9, France
    Amino Acids 40:1333-48. 2011
    ..skeletal muscle homogenate increases strongly in the presence of creatine and with this results in phosphocreatine (PCr) production with PCr/O(2) ratio of about 5-6...
  91. pmc Muscle [phosphocreatine] dynamics following the onset of exercise in humans: the influence of baseline work-rate
    Andrew M Jones
    School of Sport and Health Sciences, St Luke s Campus, University of Exeter, Heavitree Road, Exeter EX1 2LU, UK
    J Physiol 586:889-98. 2008
    ..it is not known whether putative intracellular regulators of mitochondrial respiration (and in particular the phosphocreatine concentration, [PCr]) show similar non-linearities in their response dynamics...
  92. ncbi Glycogen turnover forms lactate during exercise
    Robert G Shulman
    Department of Diagnostic Radiology, Yale University School of Medicine, MR Research Center, New Haven, CT 06520 8043, USA
    Exerc Sport Sci Rev 33:157-62. 2005
    ..In this model, contributions to fatigue should be looked for in the flux of glucose through glycogen rather than in the concentrations of fuel...
  93. ncbi Impaired aerobic glycolysis in muscle phosphofructokinase deficiency results in biphasic post-exercise phosphocreatine recovery in 31P magnetic resonance spectroscopy
    T Grehl
    Department of Neurology, BG Kliniken Bergmannsheil, Ruhr University Bochum, Germany
    Neuromuscul Disord 8:480-8. 1998
    ..During ischemic exercise the absence of glycolytic ATP formation resulted in a linear time course of phosphocreatine breakdown and a moderate alkalinization...
  94. pmc Phosphocreatine as an energy source for actin cytoskeletal rearrangements during myoblast fusion
    Roddy S O'Connor
    Emory University, Department of Pharmacology, 1510 Clifton Rd, Room 5027, Atlanta, GA 30322, USA
    J Physiol 586:2841-53. 2008
    ..Here, we demonstrate a novel role for phosphocreatine (PCr) as a spatiotemporal energy buffer during primary mouse myoblast fusion with nascent myotubes...
  95. ncbi Role of creatine kinase isoenzymes on muscular and cardiorespiratory endurance: genetic and molecular evidence
    M Echegaray
    Department of Biology, University of Puerto Rico at Cayey
    Sports Med 31:919-34. 2001
    ..Among these are the genes for the various creatine kinase (CK) isoenzyme subunits. CK and phosphocreatine (PCr) form an important metabolic system for temporal and spatial energy buffering in cells with large ..
  96. ncbi Skin phosphocreatine
    Alexander Zemtsov
    Indiana University School of Medicine, Muncie, IN 47303, USA
    Skin Res Technol 13:115-8. 2007
    ..immunohistochemistry and molecular biology techniques identified the presence of large quantities of phosphocreatine in human skin. Phosphocreatine molecules regenerate ATP cellular reserves during ischemia...
  97. ncbi Effect of creatine supplementation on phosphocreatine resynthesis, inorganic phosphate accumulation and pH during intermittent maximal exercise
    R J Yquel
    Laboratoire de Physiologie de l Exercise Musculaire et du Sport, Universite Victor Segalen, Bordeaux, France
    J Sports Sci 20:427-37. 2002
    In this study, we examined the effect of creatine ingestion on muscle power output, muscle phosphocreatine resynthesis, inorganic phosphate and pH during repeated brief bouts of maximal exercise...
  98. ncbi Relation between in vivo and in vitro measurements of skeletal muscle oxidative metabolism
    D E Larson-Meyer
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
    Muscle Nerve 24:1665-76. 2001
    ..90-s isometric plantar flexion exercises, calf muscle mitochondrial function was determined from the phosphocreatine (PCr) recovery time constant, the adenosine diphosphate (ADP) recovery time constant, the rate of change of ..
  99. ncbi 31P NMR detection of subcellular creatine kinase fluxes in the perfused rat heart: contractility modifies energy transfer pathways
    Frederic Joubert
    INSERM U 446, Cardiologie Cellulaire et Moléculaire, Universite Paris Sud, Faculte de Pharmacie, 92296 Chatenay Malabry, France
    J Biol Chem 277:18469-76. 2002
    The subcellular fluxes of exchange of ATP and phosphocreatine (PCr) between mitochondria, cytosol, and ATPases were assessed by (31)P NMR spectroscopy to investigate the pathways of energy transfer in a steady state beating heart...
  100. ncbi Increased recovery rates of phosphocreatine and inorganic phosphate after isometric contraction in oxidative muscle fibers and elevated hepatic insulin resistance in homozygous carriers of the A-allele of FTO rs9939609
    Louise G Grunnet
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 94:596-602. 2009
    ..We studied the role of the A-allele in the regulation of peripheral organ functions involved in the pathogenesis of obesity and type 2 diabetes...
  101. pmc Temperature preconditioning of isolated rat hearts--a potent cardioprotective mechanism involving a reduction in oxidative stress and inhibition of the mitochondrial permeability transition pore
    Igor Khaliulin
    Department of Biochemistry, Bristol Heart Institute, University of Bristol, UK
    J Physiol 581:1147-61. 2007
    ..The presence of N-(2-mercaptopropionyl) glycine during TP also abolished cardioprotection, indicating an involvement of free radicals in the signalling mechanism...

Research Grants63

  1. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..Our preliminary data from hibernating pig hearts show that the phosphorylation state, as measured by the phosphocreatine (PCr) to ATP ratio during dobutamine is reduced proportionate to the increased UCP-2 content ex vivo...
  2. Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant Depression
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..These include beta-nucleoside triphosphate (!-NTP;largely adenosine triphosphate, or ATP) and phosphocreatine (PCr)...
  3. PET Imaging of Myocardial Oxidative Stress in T2DM
    KOORESH ISAAC SHOGHI; Fiscal Year: 2013
    ..oxidation and esterification (using [11]C-palmitate) with PET;myocardial energetics as defined by the phosphocreatine and adenosine triphosphate concentrations and their ratio and creatine kinase flux using [31]P-MRS;and left ..
  4. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
    ..results in altered glucose metabolism, the reduction of intracellular energy metabolites such as ATP, ADP and phosphocreatine and the accumulation of metabolic intermediates, such as lactate and adenosine...
  5. MAGNETIZATION TRANSFER MRS IN METHAMPHETAMINE USERS RESUBMISSION
    Young Hoon Sung; Fiscal Year: 2013
    ..Our preliminary data provides the first evidence that METH uses have decreased frontal phosphocreatine (PCr) levels compared to healthy controls...
  6. Comprehensive Magnetic Resonance in PAD
    Christopher M Kramer; Fiscal Year: 2013
    ..We have established phosphocreatine (PCr) recovery kinetics after exercise by 31P spectroscopy (MRS) as a reliable and reproducible marker of PAD...
  7. Cardiomyocyte Lineage and Turnover by Metabolic Fate-Mapping
    Richard T Lee; Fiscal Year: 2013
    ..metabolic tracer, specifically creatine, which is taken up by cells and utilized in the cytoplasmic phosphocreatine shuttle...
  8. Molecular Signaling of AMPK Activation in Sensory Hair Cells via Traumatic Noise
    KAYLA RENEE HILL; Fiscal Year: 2013
    ..The cellular energy buffer phosphocreatine will be used to prevent noise-induced energy depletion...
  9. Noninvasive assessment of microvascular function in aging
    Jill M Slade; Fiscal Year: 2013
    ..We will also examine the effect of age on phosphocreatine (PCr) recovery kinetics;PCr kinetics reflect oxidative ATP synthesis...
  10. 31P magnetization transfer study of bipolar disorder
    Chun S Zuo; Fiscal Year: 2010
    ..In such patients, magnetic resonance spectroscopy (MRS) studies have consistently found decreases in phosphocreatine (PCr) levels, PET and SPECT studies have often reported cerebral energetic alterations and mitochondrial ..
  11. Identification of MRS Markers of Glioma Progression
    Tracy Richmond McKnight; Fiscal Year: 2010
    ..The aims of this project will test the following hypotheses: (1) reductions in the creatine+phosphocreatine peak and elevations in the peak corresponding to lactate are observed more often in Grade II OD and Grade ..
  12. DETERMINANTS OF ROD AND CONE RESPONSE CHARACTERISTICS
    JAMES BRYANT HURLEY; Fiscal Year: 2013
    ..ATP in the cell body is converted to phosphocreatine by a mitochondrial creatine kinase...
  13. PCr-based fMRSI Biomarker for Schizophrenia
    Jay W Pettegrew; Fiscal Year: 2012
    ..recent in vivo 31P-1H MRS study of normal childhood and adolescent subjects (N = 105, 6-18 years) showed that phosphocreatine (PCr) is the most sensitive molecular biomarker for regionally specific synaptic elimination...
  14. Regulation of energy metabolism in the failing heart
    Raymond Russell; Fiscal Year: 2005
    ..proposed studies will test the novel hypothesis that the changes in the high energy phosphates (ATP, AMP, and phosphocreatine) that occur in the setting of heart failure regulate the switch from fatty acid oxidation to carbohydrate ..
  15. Creatine Safety, Tolerability, and Efficacy in Huntington's Disease: CREST-E
    Steven M Hersch; Fiscal Year: 2013
    ..Creatine is an inexpensive and well-tolerated nutritional supplement that is converted in the body to phosphocreatine that acts as a high- energy phosphate store for restoring ATP from ADP...
  16. GENETIC APPROACHES TO MITOCHONDRIAL VDAC FUNCTION
    William Craigen; Fiscal Year: 2001
    ..This group of kinases is important in a variety of metabolic functions including glycolysis, the phosphocreatine circuit, triglyceride metabolism, and glucose homeostasis...
  17. PHOSPHORUS MRS OF NORMAL HUMAN MASSETER MUSCLE
    Octavia Plesh; Fiscal Year: 1991
    ..are: 1) to obtain normative data on high-energy phosphorus metabolites such as adenosine triphosphate (ATP), phosphocreatine (PCr), and inorganic phosphate (Pi) as well as pH in healthy human masseter muscles at rest, and 2) to study ..
  18. NONINVASIVE HIGH ENERGY PHOSPHATE IMAGING
    PAUL BOTTOMLEY; Fiscal Year: 1999
    ..access to key HEP metabolites such as adenosine triphosphate (ATP), the body's essential energy currency, and phosphocreatine (PCr), a key energy reserve...
  19. REGULATION OF EXPRESSION OF CREATINE KINASE GENE FAMILY
    Joseph Billadello; Fiscal Year: 1992
    Creatine kinase (EC 2.7.3.2) is essential for maintaining proper intracellular ATP:ADP ratios and phosphocreatine pool size and plays a prominent role in cardiac and skeletal muscle energy metabolism...
  20. Creatine Transport Across the Blood Brain Barrier
    Joseph Clark; Fiscal Year: 2006
    ..Despite a growing body of knowledge about the Cr, Cr kinase and phosphocreatine system in the brain, there is no standardized method for improving brain function when the brain creatine ..
  21. The role of creatine in health and disease
    William Craigen; Fiscal Year: 2009
    ..The most significant utilization of creatine occurs in muscle and brain. In these organs, creatine and phosphocreatine, together with creatine kinase isozymes and ATP/ADP, provide the major reserve of energy...
  22. CREATINE KINASE AND BRAIN ENERGETICS
    David Holtzman; Fiscal Year: 1999
    ..The first hypothesis is that the phosphocreatine (PCr)/creatine kinase (CK)/ATP system, including the mitochondrial CK (MiCK), closely couples ATP synthesis ..
  23. PERFUSION AND METABOLISM IN COLLATERALIZED MYOCARDIUM
    ROBERT BACHE; Fiscal Year: 2001
    ..Myocardial phosphocreatine (PCr), ATP and inorganic phosphate (Pi) will be measured in 3 transmural left ventricular layers using 31 P ..
  24. PREDICTING HUMAN TUMOR RESPONSE BY 31P MRS
    Jeffrey Evelhoch; Fiscal Year: 1999
    ..These include elevations of phosphomonoesters (PME), phosphodiesters (PDE), and cellular pH, and dimished phosphocreatine (PCr)...
  25. CREATINE HOMEOSTASIS IN HEALTH AND DISEASE
    John Loike; Fiscal Year: 1992
    Creatine (Cr) and phosphocreatine (PCr), essentials constituents of heart, brain,-skeletal muscle, and macrophages, are involved in a variety of cellular processes including energy transduction, mitosis, and glycolysis...
  26. PHOSPHORUS NUCLEAR MAGNETIC RESONANCE ON CARDIAC TISSUE
    WILLIAM JACOBUS; Fiscal Year: 1980
    ..nuclear magnetic resonance which can non-invasively monitor tissue pH and the concentrations of ATP, ADP, phosphocreatine, orthophosphate, and other phosphorus containing metabolites within the cell...
  27. Prediction of Cardiomyopathy in Type I Diabetes by MRS
    Gerald Pohost; Fiscal Year: 2007
    ..We recently demonstrated a transient decrease in cardiac phosphocreatine (PCr)/ATP with handgrip stress, indicative of ischemia, in women with chest pain but no artery disease...
  28. LX MULTI-NUCLEAR SPECTROSCOPY PACKAGE
    Russell Richardson; Fiscal Year: 2000
    ..of information pertinent to the metabolic capacity and state of the muscle as indicated by variables such as phosphocreatine, inorganic phosphate, adenosine triphosphate concentrations and pH...
  29. BRAIN BLOOD FLOW AND METABOLISM IN HYPOXIA-ISCHEMIA
    MYRON GINSBERG; Fiscal Year: 1980
    ..In other brains, regional energy metabolites (phosphocreatine, adenosine, triphoshate (ATP), and lactate) will be assayed and correlated with regional cerebral blood flow ..
  30. NEUROIMAGING AND STROKE REHABILITATION PROGNOSIS
    James Mountz; Fiscal Year: 1999
    ..MRSI measures of lactate, choline, creatine, N-acetyl aspartate, glutamate, inorganic phosphate, ATP , and phosphocreatine. Together the measures will provide a way to identify and quantitate recoverable components of stroke effects...
  31. PREDICTING THE RESPONSE OF TUMOR TO RADIATION
    Paul Okunieff; Fiscal Year: 1992
    ..Non-invasive measurement of several tissue oxygenation related metabolic parameters including: phosphocreatine (PCr); Pi; phosphomonoesters; phosphodiesters; pH; nulceotide triphosphates; and lactate will be performed...
  32. SKELETAL MUSCLE ENERGY METABOLISM IN SURGICAL PATIENTS
    Danny Jacobs; Fiscal Year: 1993
    ..The relative quantities of ATP, phosphocreatine, and inorganic phosphate will be measured and the rate of reconstitution of the high energy pool will be ..
  33. DO GLUCOCORTICOIDS EXACERBATE GP120 NEUROENDANGERMENT
    Robert Sapolsky; Fiscal Year: 2002
    ..GCs; c) if GCs exacerbate the suppressive effects of gp120 on metabolism or gp120-induced declines in ATP and phosphocreatine content; e) if GCs increase the toxicity of gp120...
  34. NMR STUDIES OF NORMAL AND DISEASED HUMAN LIMBS
    Britton Chance; Fiscal Year: 1990
    ..of the basic "toe-up" exercise protocol are specialized for particular patient populations; 1) resting phosphocreatine/phosphate determinations in severly diseased patients and 2) in-magnet graded exercise protocols will be ..
  35. ENERGETICS OF THE FAILING HEART
    JOANNE INGWALL; Fiscal Year: 2003
    ..on results using NMR spectroscopy and chemical assay, we and others have shown that the tissue contents of phosphocreatine (PCr) and creatine and the capacity of the CK reaction (Vmax) are also lower...
  36. CREATINE THERAPY TO TREAT HUNTINGTON'S DISEASE: A PHASE 3 STUDY
    Steven M Hersch; Fiscal Year: 2010
    ..potential and calcium homeostasis, the loss of either of which leads to neuronal dysfunction and death;(2) phosphocreatine regenerates ATP in the cytoplasm that is then utilized by the sodium potassium ATPase to maintain membrane ..
  37. IN VIVO MR STUDIES OF METABOLISM IN ALZHEIMERS DISEASE
    JAY PETTEGREW; Fiscal Year: 2000
    ..increased membrane synthesis [increased phosphomonoesters (PME)] and increased energetic stress [decreased phosphocreatine (PCr)]...
  38. Neural Damage in Methamphetamine Users: An MRS Study
    THOMAS NORDAHL; Fiscal Year: 2004
    ..in conjunction with mature neurons (primarily N- acetyl aspartase [NAA], high energy metabolic products (phosphocreatine and creatine [Cr], cell membrane synthesis or degradation (choline [Cho]), and glia (myoInositol [mI)...
  39. ANNUAL MRI, MTR AND HMRSI IN HEALTHY CONTROLS AND PPMS
    Stephen Hauser; Fiscal Year: 2001
    ..of MT ratios, T2 relaxation times and HMRSI spectral intensities of N-acetyl aspartate (NAA), creatine/phosphocreatine (Cr) and choline (Chol) in patients randomly assigned to treatment with MTXN 12 mg/m2 or placebo administered ..
  40. NO-MEDIATED MODIFICATION OF NMDA RECEPTOR DURING HYPOXIA
    Om Mishra; Fiscal Year: 2008
    ..abstract_text> ..
  41. NO-MEDIATED MODIFICATION OF NMDA RECEPTOR DURING HYPOXIA
    Om Mishra; Fiscal Year: 2006
    ..abstract_text> ..
  42. IN VIVO NMR STUDIES IN SCHIZOPHRENIA
    JAY PETTEGREW; Fiscal Year: 2000
    ..to date demonstrate decreased membrane synthesis [phosphomonoesters (PME)] and decreased energy consumption [phosphocreatine (PCr) and ATP] in the drug-naive, first-episode schizophrenics as contrasted with increased PME in autistics...
  43. PREDICTING HUMAN TUMOR RESPONSE BY 31P MRS
    Martin Leach; Fiscal Year: 1999
    ..These include raised levels of phosphomonoesters (PME), phosphodiesters (PDE) and cellular pH, and reduced phosphocreatine (PCr)...
  44. GLUTAMATE, EXCITOTOXINS AND NEURONAL/GLIAL INTERACTIONS
    WILLIAM NICKLAS; Fiscal Year: 1999
    ..by hypothermia, and include studies of temperature range effects on protection, measurement of ATP and phosphocreatine levels, and the possible role of Na+,K+-ATPase in this protection...
  45. RESPONSE OF THE AGING NERVOUS SYSTEM TO TRAUMA
    Stephen Scheff; Fiscal Year: 2007
    ..Specific aim #4 will use a 'creatine-supplemented' dietary intervention that enhances cytosolic phosphocreatine and increases the ability of neurons to produce ATP, an intervention to reverse the age-related response to ..
  46. ADAPTATION TO FUNCTIONAL OVERLOAD IN MUSCLE FIBER TYPES
    KENNETH BALDWIN; Fiscal Year: 1980
    ..properties of the enlarged muscles in terms of contractile and relaxation speed and endogenous utilization of phosphocreatine and glycogen...
  47. IN VIVO CEREBRAL OXIDATIVE METABOLISM IN HYPOXIC NEWBORNS
    MARIA D DELIVORIA PAPADOPOULOS; Fiscal Year: 2010
    ..abstract_text> ..
  48. RESPIRATION AND GLYCOLYSIS--INTEGRATION IN ACTIVE MUSCLE
    Kevin Conley; Fiscal Year: 2002
    ..g., diabetes. An understanding of the integration of metabolism in healthy tissue is the first step to understanding how failure of integration limits function in diseased muscle. ..
  49. Magnetic Resonance Spectroscopy in Affective Illness
    CONSTANCE MOORE; Fiscal Year: 2005
    ..Decreased caudate nucleus beta-NTP will be associated with depression. An increase in caudate nucleus PME will occur as a result of lithium treatment. ..
  50. SODIUM IMAGING IN ISCHEMIC HEART DISEASE
    PAUL BOTTOMLEY; Fiscal Year: 2002
    ..The availability of thousands of clinical MRI scanners offers a great opportunity for advancing 23Na MRI as a tool for assessing sodium pump function in human heart disease. ..
  51. MYOCARDIAL ENERGY METABOLISM IN THE DYSFUNCTIONAL LV
    Jianyi Zhang; Fiscal Year: 2003
    ..contributes to the transition between stable remodeling and CHF and, iii. Whether a metabolic intervention can attenuate the remodeling response and the transition from stable remodeling to CHF. ..
  52. Innovative MRI Research Technology
    PAUL BOTTOMLEY; Fiscal Year: 2005
    ..The work will be implemented at 1 .5T and will directly and positively benefit 21 other funded research grants at this institution, with broad potential benefit to noninvasive imaging in a wide range of patients and diseases. ..
  53. Stem cell patch therapy in hearts with LV infarction
    Jianyi Zhang; Fiscal Year: 2004
    ..By providing insight into the effects of the cellular patch transplantation, the results may lead to better preventive, diagnostic and therapeutic modalities for LV injury. ..
  54. MR Studies of Myocardial Creatine Kinase Metabolism
    PAUL BOTTOMLEY; Fiscal Year: 2007
    ..phosphorus (31P) is uniquely able to noninvasively assess key metabolites, adenosine triphosphate (ATP) and phosphocreatine (PCr), in the heart. Patient MRS studies show reduced PCr and ATP: levels in myocardial infarction (MI)...
  55. ENERGETICS IN HYPERTROPHIED AND REMODELED LEFT VENTRICLE
    Jianyi Zhang; Fiscal Year: 2009
    ..The results of these experiments may lead to better preventive and therapeutic modalities for heart failure. ..
  56. Metabolic MRI of Diabetic Lower Extremity Disease
    Robert L Greenman; Fiscal Year: 2010
    ....
  57. Phosphorus MRI of the Lower Extremeties in Diabetics
    ROBERT GREENMAN; Fiscal Year: 2003
    ..g. phosphocreatine) in human skeletal muscle...
  58. Cerebral edema in pediatric ketoacidosis
    Nicole Glaser; Fiscal Year: 2009
    ..This initial animal data will form the basis for a randomized clinical trial of interventions for the prevention of CE in children with DKA which will be the main focus of the study. ..
  59. Brain Imaging in Panic Disorder at High-Field
    Seth Friedman; Fiscal Year: 2008
    ..By integrating time-resolved central and peripheral nervous system measures of physiological regulation, the components of altered physiology in PD will be elucidated. ..
  60. Brain Chemistry and Treatment Response in Pediatric MDD
    David Rosenberg; Fiscal Year: 2005
    ..An understanding of the neurochemical disturbances in MDD may be important for the development of new treatment approaches. ..
  61. Central Adaptations to Creatine Supplementation in Older Men and Women
    ERIC RAWSON; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  62. 23NaMRI of breast cancer
    Ronald Ouwerkerk; Fiscal Year: 2004
    ..abstract_text> ..