valine

Summary

Summary: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.

Top Publications

  1. ncbi The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
  2. ncbi Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression
    F Al-Mulla
    The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    J Pathol 187:433-8. 1999
  3. ncbi Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus
    Nicolas Nagot
    Centre Muraz, Bobo Dioulasso, Burkina Faso
    N Engl J Med 356:790-9. 2007
  4. ncbi Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
  5. ncbi The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria
    Angela Sutton
    Institut National de la Santé et de la Recherche Médicale Unité 481, Hopital Beaujon, Clichy, France
    Pharmacogenetics 13:145-57. 2003
  6. ncbi Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study
    Seibu Mochizuki
    Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Lancet 369:1431-9. 2007
  7. ncbi Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression
    Justine M Gatt
    Brain Dynamics Center, University of Sydney Medical School and Westmead Millennium Institute, Australia
    Biol Psychiatry 68:818-24. 2010
  8. ncbi Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia
    Monica Gratacos
    Genes and Disease Program, Center for Genomic Regulation CRG, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain
    Biol Psychiatry 61:911-22. 2007
  9. ncbi Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
    Richard A Zuckerman
    Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Infect Dis 196:1500-8. 2007
  10. ncbi A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition
    Anil K Malhotra
    Unit of Molecular Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 159:652-4. 2002

Detail Information

Publications380 found, 100 shown here

  1. ncbi The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    ..We examined the effects of a valine (val) to methionine (met) substitution in the 5' pro-region of the human BDNF protein...
  2. ncbi Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression
    F Al-Mulla
    The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    J Pathol 187:433-8. 1999
    Recent evidence associates the codon 12 valine-for-glycine (G12V) mutant Ki-Ras protein with higher stage and increased lethality of colorectal carcinomas, while the codon 12 aspartate-for-glycine (G12D) Ras mutation shows no such ..
  3. ncbi Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus
    Nicolas Nagot
    Centre Muraz, Bobo Dioulasso, Burkina Faso
    N Engl J Med 356:790-9. 2007
    ..Epidemiologic data suggest that infection with herpes simplex virus type 2 (HSV-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (HIV-1) RNA and HIV-1 transmissibility...
  4. ncbi Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression
    Thomas Frodl
    Department of Psychiatry and Psychotherapy and Radiology, Ludwig Maximilians University, Munich, Germany
    Arch Gen Psychiatry 64:410-6. 2007
    ..Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression...
  5. ncbi The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria
    Angela Sutton
    Institut National de la Santé et de la Recherche Médicale Unité 481, Hopital Beaujon, Clichy, France
    Pharmacogenetics 13:145-57. 2003
    A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence (MTS) of human manganese superoxide dismutase (MnSOD) and has been reported to modulate the risk of some cancers, ..
  6. ncbi Valsartan in a Japanese population with hypertension and other cardiovascular disease (Jikei Heart Study): a randomised, open-label, blinded endpoint morbidity-mortality study
    Seibu Mochizuki
    Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Lancet 369:1431-9. 2007
    ..We aimed to investigate whether addition of an angiotensin receptor blocker, valsartan, to conventional cardiovascular treatment was effective in Japanese patients with cardiovascular disease...
  7. ncbi Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depression
    Justine M Gatt
    Brain Dynamics Center, University of Sydney Medical School and Westmead Millennium Institute, Australia
    Biol Psychiatry 68:818-24. 2010
    ..They have largely been studied in isolation...
  8. ncbi Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia
    Monica Gratacos
    Genes and Disease Program, Center for Genomic Regulation CRG, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain
    Biol Psychiatry 61:911-22. 2007
    ..The valine (Val)66-to-methionine (Met) variant, located in the pro brain-derived neurotrophic factor (BDNF) sequence, has ..
  9. ncbi Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial
    Richard A Zuckerman
    Section of Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    J Infect Dis 196:1500-8. 2007
    ..We studied HIV-1 levels during HSV suppression in coinfected persons in a placebo-controlled crossover trial...
  10. ncbi A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition
    Anil K Malhotra
    Unit of Molecular Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 159:652-4. 2002
    ..The COMT gene contains a functional polymorphism, Val158Met, that exerts a fourfold effect on enzyme activity. The current study investigated whether prefrontal cognition varies with COMT genotype...
  11. ncbi Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors
    Francesca Carlomagno
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Via S Pansini 5, Napoli, Italia
    Oncogene 23:6056-63. 2004
    ..In contrast, MEN2-associated swap of bulky hydrophobic leucine or methionine residues for valine 804 in the RET kinase domain causes resistance to the three compounds...
  12. pmc Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase
    Xin Chen
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, The Chinese Academy of Sciences, Shanghai 200031, China
    Nucleic Acids Res 39:235-47. 2011
    ..Post-transfer editing as a final checkpoint of the reaction was very important to prevent mis-incorporation in vitro. These results provide insight into the modular editing pathways created to prevent genetic code ambiguity by evolution...
  13. ncbi Importance of NADPH supply for improved L-valine formation in Corynebacterium glutamicum
    Tobias Bartek
    Institute of Biotechnology 2, Forschungszentrum Julich, Julich 52425, Germany
    Biotechnol Prog 26:361-71. 2010
    Cofactor recycling is known to be crucial for amino acid synthesis. Hence, cofactor supply was now analyzed for L-valine to identify new targets for an improvement of production...
  14. ncbi Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
    ..Individuals homozygous for the high-activity valine ("val") allele show greater activity and poorer performance than val/methionine ("met") heterozygotes, who in turn ..
  15. ncbi A family with Stickler syndrome type 2 has a mutation in the COL11A1 gene resulting in the substitution of glycine 97 by valine in alpha 1 (XI) collagen
    A J Richards
    Department of Pathology, University of Cambridge, UK
    Hum Mol Genet 5:1339-43. 1996
    ..vitreous and retinal abnormalities is linked to the COL11A1 gene and characterise the mutation as a Glycine to Valine substitution at position 97 of the triple helical domain caused by a single base G-->T mutation...
  16. pmc Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation
    Jin Hwan Park
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305 701, Korea
    Proc Natl Acad Sci U S A 104:7797-802. 2007
    The L-valine production strain of Escherichia coli was constructed by rational metabolic engineering and stepwise improvement based on transcriptome analysis and gene knockout simulation of the in silico genome-scale metabolic network...
  17. pmc High-dose valacyclovir HSV-2 suppression results in greater reduction in plasma HIV-1 levels compared with standard dose acyclovir among HIV-1/HSV-2 coinfected persons: a randomized, crossover trial
    Kenneth Mugwanya
    Infectious Diseases Institute, Makerere University, Kampala, Uganda
    J Infect Dis 204:1912-7. 2011
    ..Standard-dose HSV-2 suppressive therapy (acyclovir 400 mg twice daily) reduces plasma HIV-1 levels by 0.25-0.50 log(10) copies/mL. It is not known if higher doses might further suppress HIV-1 levels...
  18. ncbi A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder
    Avshalom Caspi
    Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 65:203-10. 2008
    ..Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous neurodevelopmental disorder that in some cases is accompanied by antisocial behavior...
  19. ncbi The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life
    Marieke Wichers
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 33:3030-6. 2008
    ..Genetic moderation of ecological measures of reward experience is hypothesized to be of major relevance to the development of various behavioral disorders, including depression and addiction...
  20. ncbi Clinical characteristics of patients with asymptomatic recurrences of atrial fibrillation in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Atrial Fibrillation (GISSI-AF) trial
    Marcello Disertori
    Department of Cardiology, Santa Chiara Hospital, Trento, Italy
    Am Heart J 162:382-9. 2011
    ..In a consistent percentage of cases, AF recurrences are asymptomatic, thus making its clinical management difficult in relation to both therapeutic efficacy and thromboembolic risk...
  21. ncbi Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models
    Cathy C Zhang
    Oncology Research Unit and Drug Safety, Pfizer Global Research and Development, La Jolla, CA 92129, USA
    Clin Cancer Res 18:5008-19. 2012
    ..We aimed to assess the biologic activity of PF-03084014 in breast xenograft models. The biomarkers for mechanism and patient stratification were also explored...
  22. pmc Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers
    Beng Choon Ho
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, USA
    Arch Gen Psychiatry 63:731-40. 2006
    ..suggest that a brain-derived neurotrophic factor (BDNF) prodomain single nucleotide polymorphism resulting in a valine (Val)-to-methionine (Met) substitution is associated with impaired declarative memory in healthy volunteers and ..
  23. pmc Effect of Renin-Angiotensin system blockade on insulin resistance and inflammatory parameters in patients with impaired glucose tolerance
    Stefan Pscherer
    Department of Nephrology and Diabetology, KlinikumTraunstein, Traunstein, Germany
    Diabetes Care 33:914-9. 2010
    ..The study investigated the effect of angiotensin receptor blockers (ARB) on glucose homeostasis and inflammatory parameters in patients with impaired glucose tolerance (IGT)...
  24. ncbi Variant BDNF (Val66Met) impact on brain structure and function
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 244, New York, NY 10021, USA
    Cogn Affect Behav Neurosci 6:79-85. 2006
    ..We review the recent literature linking this BDNF polymorphism to cognitive impairment in the context of in vitro and transgenic animal studies that have established BDNF's central role in neuronal functioning in the adult brain...
  25. ncbi Valsartan: more than a decade of experience
    Henry R Black
    New York University Center for the Prevention of Cardiovascular Disease, New York University School of Medicine, New York, New York 10003, USA
    Drugs 69:2393-414. 2009
    ..The combination of valsartan/HCTZ was better tolerated than HCTZ alone. Valsartan is administered once daily for hypertension; doses are usually taken upon awakening. In patients with HF or MI, valsartan is administered twice daily...
  26. pmc Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease
    Jun Wang
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Clin Invest 117:3393-402. 2007
    ..These preclinical studies suggest that certain antihypertensive drugs may have AD-modifying activity and may protect against progressive Abeta-related memory deficits in subjects with AD or in those at high risk of developing AD...
  27. pmc CDK5 serves as a major control point in neurotransmitter release
    Sung Hyun Kim
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
    Neuron 67:797-809. 2010
    ..These studies thus pinpoint CDK5 as a major control point for modulation of neurotransmitter release in mammalian neurons...
  28. pmc COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals
    Nancy A Dennis
    Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA
    Cereb Cortex 20:672-83. 2010
    ..Taken together, the results suggest that although the COMT val108/158met genotype has no effect on cognitive behavioral measures in healthy individuals, it is associated with differences in neural process underlying cognitive output...
  29. ncbi Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial
    Stevo Julius
    University of Michigan, Ann Arbor, USA
    Lancet 363:2022-31. 2004
    ....
  30. pmc COMT Val158Met Genotype and Individual Differences in Executive Function in Healthy Adults
    Heather A Wishart
    Department of Psychiatry, Dartmouth Medical School, Lebanon, New Hampshire 03756 0001, USA
    J Int Neuropsychol Soc 17:174-80. 2011
    ..This study suggests the heterogeneity in COMT effects reported in the literature may be due in part to gene-gene interactions that influence central dopaminergic systems...
  31. pmc Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia
    Diana P Prata
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London WC2R 2LS, United Kingdom
    Proc Natl Acad Sci U S A 106:13600-5. 2009
    ....
  32. ncbi The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism
    Iris Tatjana Kolassa
    University of Konstanz, Germany
    Biol Psychiatry 67:304-8. 2010
    ..The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders...
  33. pmc Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls
    Catherine M Diaz-Asper
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 63:72-9. 2008
    ..Recently, other single nucleotide polymorphisms (SNPs) across the gene have emerged as additional risk factors for schizophrenia: namely rs737865, rs165599, and rs2097603. In a large sample, we examined whether these SNPs affect WM...
  34. ncbi Influence of methionine/valine-depleted enteral nutrition on nucleic acid and protein metabolism in tumor-bearing rats
    Yin Cheng He
    Department of General Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    World J Gastroenterol 9:771-4. 2003
    To investigate the effects of methionine/valine-depleted enteral nutrition (EN) on RNA, DNA and protein metabolism in tumor-bearing (TB) rats.
  35. ncbi V180I mutation of the prion protein gene associated with atypical PrPSc glycosylation
    Stephanie Chasseigneaux
    UPRES EA 3621, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris 5 et Service de Biochimie et Biologie Moléculaire, Hopital Lariboisiere, 2 rue A Pare, 75475 Paris Cedex 10, France
    Neurosci Lett 408:165-9. 2006
    A valine to isoleucine mutation at residue 180 was identified in a French patient with Creutzfeldt-Jakob disease (CJD)...
  36. ncbi Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure
    Eiichiro Yamamoto
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjyo, Kumamoto 860 8556, Japan
    Arterioscler Thromb Vasc Biol 27:2569-75. 2007
    ..We examined the molecular mechanism of angiotensin (AII)-induced vascular endothelial injury and its significance for hypertensive diastolic heart failure...
  37. ncbi Role of valine 464 in the flavin oxidation reaction catalyzed by choline oxidase
    Steffan Finnegan
    Department of Chemistry, Georgia State University, Atlanta, Georgia 30302 4098, USA
    Biochemistry 49:2952-61. 2010
    ..Mechanistic considerations provide rationalization for the differences between sites in monooxygenases and oxidases...
  38. ncbi [Overproduction of noncanonical amino acids by Escherichia coli cells]
    E V Sycheva
    Mikrobiologiia 76:805-12. 2007
    ..When grown under valine limitation, E...
  39. ncbi Efficacy of various antihypertensive agents as evaluated by indices of vascular stiffness in elderly hypertensive patients
    Takeshi Takami
    Clinic Jinguumae, Kashihara, Japan
    Hypertens Res 26:609-14. 2003
    ....
  40. ncbi The association between the methionine/valine (M/V) polymorphism (rs1799990) in the PRNP gene and the risk of Alzheimer disease: an update by meta-analysis
    Jie He
    West China Medical School West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
    J Neurol Sci 326:89-95. 2013
    ..The aim of this study is to evaluate the association between the M/V polymorphism in the PRNP gene and the risk of AD...
  41. pmc Nicotine abstinence-induced cerebral blood flow changes by genotype
    Ze Wang
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, United States
    Neurosci Lett 438:275-80. 2008
    ..While preliminary, these results suggest a neural mechanism through which these genetic variants may be linked with nicotine dependence, and provide further support for increased biological vulnerability in these subgroups of smokers...
  42. ncbi Corynebacterium glutamicum tailored for high-yield L-valine production
    Bastian Blombach
    Institute of Microbiology and Biotechnology, University of Ulm, Ulm, Germany
    Appl Microbiol Biotechnol 79:471-9. 2008
    We recently engineered the wild type of Corynebacterium glutamicum for the growth-decoupled production of L: -valine from glucose by inactivation of the pyruvate dehydrogenase complex and additional overexpression of the ilvBNCE genes, ..
  43. pmc A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments
    Raquel Y Salinas
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 8:e54292. 2013
    ..We also conducted alanine scanning of all residues within this sequence and found that only a single residue, valine at position 332, is essential for outer segment targeting...
  44. ncbi Catechol-o-methyltransferase (COMT) and proline dehydrogenase (PRODH) mRNAs in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and major depression
    Elizabeth Tunbridge
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford, OX3 7JX, UK
    Synapse 51:112-8. 2004
    ....
  45. ncbi Rationale and design of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial
    Augustine N Odili
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Blood Press 20:256-66. 2011
    ....
  46. ncbi Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health
    Craig A Olsson
    Centre for Adolescent Health, Murdoch Children s Research Institute, Royal Children s Hospital, University of Melbourne, Victoria, Australia
    Psychiatr Genet 15:109-15. 2005
    ..Two recent reports have observed the association between the MetMet genotype and risk of anxiety in adult populations. We examined the association between the ValMet genotypes and propensity to anxiety across adolescence...
  47. ncbi Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51
    Kazuhiko Ochiai
    Department of Basic Science, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan
    FEBS Lett 585:1771-7. 2011
    ..between BRC repeat 4 (BRC4) and RAD51 was strengthened by the substitution of a single BRC4 amino acid from valine to isoleucine (V1532I). However, the cancer-associated V1532F mutant exhibited very weak interaction with RAD51...
  48. ncbi Beneficial effects of l-leucine and l-valine on arrhythmias, hemodynamics and myocardial morphology in rats
    Katarzyna Mitrega
    Chair and Department of Pharmacology, Medical University of Silesia, ul Jordana 19, 41 808 Zabrze, Poland
    Pharmacol Res 64:218-25. 2011
    ..Our study was performed to evaluate whether an infusion of either l-leucine or l-valine in a dose of 1mgkg(-1)h(-1) 10min before a 7-min period of left anterior descending artery occlusion followed by ..
  49. ncbi Irbesartan prevents metabolic syndrome in rats via activation of peroxisome proliferator-activated receptor γ
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki, Osaka, Japan
    J Pharmacol Sci 116:309-15. 2011
    ..These findings suggest that through PPARγ stimulation along with angiotensin II inhibition, irbesartan may be an optimal treatment option in the prevention of metabolic syndrome as well as hypertension...
  50. ncbi Beneficial effects of combination of valsartan and amlodipine on salt-induced brain injury in hypertensive rats
    Yi Fei Dong
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjyo, Kumamoto 860 8556, Japan
    J Pharmacol Exp Ther 339:358-66. 2011
    ..Our results suggest that the combination of valsartan and amlodipine may be a promising strategy for the prevention of salt-related brain injury in hypertensive patients...
  51. ncbi Quantification of hydroxyl radical-derived oxidation products in peptides containing glycine, alanine, valine, and proline
    Philip E Morgan
    Free Radical Group, The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, NSW 2042, Australia
    Free Radic Biol Med 52:328-39. 2012
    ..Summation of the product concentrations provides clear evidence for the occurrence of chain reactions in peptides exposed to HO(•)/O(2), with the overall product yields exceeding that of the initial HO(•) generated...
  52. pmc Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function
    Pieter J Meuwissen
    Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University, Ghent, B 9000, Belgium
    Retrovirology 9:34. 2012
    ..of nef alleles from clinical isolates, we identified a dysfunctional HIV group O Nef in which a highly conserved valine-glycine-phenylalanine (VGF) region, which links a preceding acidic cluster with the following proline-rich motif ..
  53. ncbi Isobutanol production in engineered Saccharomyces cerevisiae by overexpression of 2-ketoisovalerate decarboxylase and valine biosynthetic enzymes
    Won Heong Lee
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Bioprocess Biosyst Eng 35:1467-75. 2012
    ..was attempted by overexpression of effective 2-keto acid decarboxylase (KDC) and combinatorial overexpression of valine biosynthetic enzymes in S. cerevisiae D452-2...
  54. ncbi Study and reengineering of the binding sites and allosteric regulation of biosynthetic threonine deaminase by isoleucine and valine in Escherichia coli
    Lin Chen
    Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People s Republic of China
    Appl Microbiol Biotechnol 97:2939-49. 2013
    ..This work builds a solid basis for the reengineering of TD and related microorganisms for Ile production...
  55. pmc Engineering of Corynebacterium glutamicum for high-yield L-valine production under oxygen deprivation conditions
    Satoshi Hasegawa
    Research Institute of Innovative Technology for the Earth, Kizugawadai, Kizugawa, Kyoto, Japan
    Appl Environ Microbiol 79:1250-7. 2013
    We previously demonstrated efficient L-valine production by metabolically engineered Corynebacterium glutamicum under oxygen deprivation...
  56. ncbi Effects of an N-type calcium antagonist on angiotensin II-renin feedback
    Shizuka Aritomi
    Pharmaceutical Research Laboratories, Ajinomoto Co, Inc, Kawasaki, Japan
    Am J Nephrol 33:168-75. 2011
    ....
  57. ncbi Association between BDNF Val66Met polymorphism and age at onset in Huntington disease
    J Alberch
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
    Neurology 65:964-5. 2005
  58. ncbi Familial amyloidotic polyneuropathy: a new transthyretin position 30 mutation (alanine for valine) in a family of German descent
    L A Jones
    Department of Medicine, Boston City Hospital, MA
    Clin Genet 41:70-3. 1992
    ..This mutation results in a previously undescribed substitution of an alanine for valine in the final TTR protein...
  59. pmc Participation of valine 171 in alpha-Helix 5 of Bacillus thuringiensis Cry1Ab delta-endotoxin in translocation of toxin into Lymantria dispar midgut membranes
    Oscar Alzate
    Biochemistry Department, The Ohio State University, 484 W 12th Avenue, Columbus, Ohio 43210, USA
    Appl Environ Microbiol 76:7878-80. 2010
    ..This is an insect-specific mechanism; similar results were not observed in Manduca sexta, another Cry1Ab δ-endotoxin-susceptible insect...
  60. ncbi Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications
    Thomas W Weickert
    National Institutes of Health, National Institute of Mental Health, Clinical Brain Disorders Branch, Building 10, Room 4C 101, MSC 1379, Bethesda, MD 20892, USA
    Biol Psychiatry 56:677-82. 2004
    ..The present study tested the effects of several COMT polymorphisms on the cognitive response to antipsychotic medication in patients with schizophrenia...
  61. ncbi Maternal administration of valaciclovir in symptomatic intrauterine cytomegalovirus infection
    F Jacquemard
    Service de Medecine Foetale, Institut de Puericulture de Paris, Paris, France
    BJOG 114:1113-21. 2007
    ..To report early experience with treatment of intrauterine cytomegalovirus (CMV) infection using maternal oral administration of valaciclovir (VACV)...
  62. ncbi Metabolic engineering of the L-valine biosynthesis pathway in Corynebacterium glutamicum using promoter activity modulation
    Jiri Holátko
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic
    J Biotechnol 139:203-10. 2009
    ..with acetohydroxy acid synthase, resistant to inhibition by all three branched-chain amino acids (L-valine, L-isoleucine and L-leucine), was used as a basis to develop a new type of valine producer by genetic engineering...
  63. ncbi Catechol O-methyltransferase variants and cognitive performance in schizophrenia and bipolar disorder versus controls
    Katrine V Wirgenes
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Schizophr Res 122:31-7. 2010
    ..However, the results have been inconsistent and there are few studies addressing other COMT single nucleotide polymorphisms (SNPs)...
  64. ncbi No association between the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and schizophrenia in Asian populations: Evidence from a case-control study and meta-analysis
    Yui Naoe
    Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Neurosci Lett 415:108-12. 2007
    ..A single nucleotide polymorphism (SNP) in the BDNF gene that causes a valine to methionine substitution at codon 66 (Val66Met) has been demonstrated to affect human memory and hippocampal ..
  65. ncbi Molecular characterization of methylmalonate semialdehyde dehydrogenase deficiency
    K L Chambliss
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA
    J Inherit Metab Dis 23:497-504. 2000
    ..No abnormalities of the MMSDH cDNA were detected in the other patients. These data provide the first molecular characterization of an inborn error of metabolism specific to the L-valine catabolic pathway.
  66. ncbi Met carriers of BDNF Val66Met genotype show increased N-acetylaspartate concentration in the anterior cingulate cortex
    Jurgen Gallinat
    Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Mitte, Berlin, Germany
    Neuroimage 49:767-71. 2010
    ..We hypothesize that higher NAA levels in the ACC might contribute to the protection of Met allele carriers against major psychiatric disorders as schizophrenia and bipolar disorder...
  67. ncbi Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism
    Thomas Foltynie
    Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Mov Disord 19:885-91. 2004
    ..We suggest that polymorphisms of common genes, which regulate central nervous system dopaminergic transmission, can influence some of the phenotypic manifestations of PD...
  68. ncbi Identification of Sc-type ILV6 as a target to reduce diacetyl formation in lager brewers' yeast
    C T Duong
    Department of Microbiology and Genetics, Berlin University of Technology, Seestr 13, D 13353 Berlin, Germany
    Metab Eng 13:638-47. 2011
    ..It is spontaneously generated from α-acetolactate, an intermediate of yeast's valine biosynthesis released during the main beer fermentation...
  69. ncbi Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties
    Shiv K Dubey
    Centre for Biotechnology, University of Allahabad, and Kamla Nehru Hospital, Allahabad 211002, India
    Eur J Med Chem 43:1837-46. 2008
    The monoesters of curcumin, a symmetric diphenol with valine and glycine have been prepared by a novel solid phase synthesis and its diesters with valine, glutamic acid and demethylenated piperic acid have been prepared by solution phase ..
  70. pmc Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Psychiatry 164:1890-9. 2007
    ..Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations...
  71. pmc Single amino acid alteration between valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2
    Xiaoqiu Yuan
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Center for Structural Biology, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China
    J Biol Chem 285:28953-8. 2010
    ..comparison and biochemical analyses demonstrated that one single amino acid alteration between a corresponding valine and isoleucine determines the distinct pyrabactin selectivity by PYL1 and PYL2...
  72. pmc The importance of valine 114 in ligand binding in beta(2)-adrenergic receptor
    Makoto Arakawa
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W4
    Protein Sci 19:85-93. 2010
    ..In this study, we have investigated the structural and functional role of a highly conserved residue valine 114, in hamster beta(2)-AR by site-directed mutagenesis...
  73. pmc Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophrenia and bipolar disorder
    Vina M Goghari
    Department of Psychology, University of Minnesota, Twin Cities, United States
    Schizophr Res 103:186-91. 2008
    ..Lifetime symptomatology may be particularly useful in determining the relationship between genes and clinical phenotypes across mental disorders...
  74. pmc BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects
    Meghana S Karnik
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Psychiatry Res 178:425-9. 2010
    ..We concluded that in a large cohort of healthy human subjects, the Met allele of rs6265 is not associated with hippocampal structure or memory performance...
  75. pmc Intramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the morphological development of cortical neurons
    Yachi Chen
    Department of Neurobiology and Behavior, State University of New York, Stony Brook, Stony Brook, New York 11794, USA
    J Neurosci 30:9199-208. 2010
    ..In particular, substitutions at valine 321, previously linked to schizophrenia risks, result in NRG1 proteins that fail to undergo gamma-secretase-..
  76. ncbi Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]
    Qianni Cheng
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    J Pharmacol Exp Ther 327:683-91. 2008
    ..Valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-l-valine] is an antagonist of the angiotensin II type 1 receptor (AT1R) that reduces the incidence of type 2 diabetes ..
  77. ncbi Additive effect of ACE inhibition and angiotensin II receptor blockade in type I diabetic patients with diabetic nephropathy
    Peter Jacobsen
    Steno Diabetes Center, Gentofte, Denmark and Faculty of Health Science, University of Aarhus, Denmark
    J Am Soc Nephrol 14:992-9. 2003
    ..All treatments were safe and well tolerated. In conclusion, dual blockade of the RAS may offer additional renal and cardiovascular protection in type I diabetic patients with DN...
  78. pmc Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy and postpartum: a randomized trial
    Alison L Drake
    Department of Global Health, University of Washington, Seattle 98195 7236, USA
    J Infect Dis 205:366-75. 2012
    ..The effect of herpes simplex virus type 2 (HSV-2) suppression on human immunodeficiency virus type 1 (HIV-1) RNA in the context of prevention of mother-to-child transmission (PMTCT) interventions is unknown...
  79. pmc 24-Hour ambulatory blood pressure control with triple-therapy amlodipine, valsartan and hydrochlorothiazide in patients with moderate to severe hypertension
    Y Lacourciere
    Hypertension Research Unit, Centre Hospitalier Universitaire de Quebec, Quebec, Canada
    J Hum Hypertens 25:615-22. 2011
    ..Once-daily treatment with amlodipine/valsartan/hydrochlorothiazide (10/320/25 mg) reduces ABP to a significantly greater extent than component-based dual therapy and maintains its effectiveness over the entire 24-h dosing period...
  80. pmc Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics
    Ignazio Cali
    Department of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Brain 132:2643-58. 2009
    ..distinct subtypes have been identified in sporadic Creutzfeldt-Jakob disease (sCJD), based on the methionine/valine polymorphic genotype of codon 129 of the prion protein (PrP) gene and the presence of either one of the two ..
  81. ncbi Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects
    Björn Pasternak
    Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
    JAMA 304:859-66. 2010
    ..Safety of these antivirals when used in the first trimester of pregnancy is insufficiently documented...
  82. ncbi Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans
    Tien V Nguyen
    Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA
    Mol Genet Metab 77:68-79. 2002
    ..A single patient has previously been described whose fibroblasts exhibit a specific deficit in the oxidation of valine. Amplified ACAD8 cDNA made from patient fibroblast mRNA was homozygous for a single nucleotide change (905G>A) ..
  83. ncbi Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution
    Giuseppe D Ciccotosto
    Department of Pathology, University of Melbourne, Victoria 3010, Australia
    J Biol Chem 279:42528-34. 2004
    ..We examined the effect of mutating the methionine to valine in Abeta42 (AbetaM35V)...
  84. ncbi Effect of valsartan addition to amlodipine on insulin sensitivity in overweight-obese hypertensive patients
    Roberto Fogari
    Department of Internal Medicine and Therapeutics, Centro per l Ipertensione e la Fisiopatologia Cardiovascolare, University of Pavia, Italy
    Intern Med 47:1851-7. 2008
    ..The aim of the study was to evaluate the effect of valsartan/amlodipine combination on insulin sensitivity in overweight-obese hypertensive patients...
  85. ncbi Association of the COMT val158met variant with antidepressant treatment response in major depression
    Bernhard T Baune
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 33:924-32. 2008
    ..This finding suggests a potentially beneficial effect of an antidepressive add-on therapy with substances increasing dopamine availability individually tailored according to COMT val158met genotype...
  86. ncbi Presence of alanine-to-valine substitutions in myofibrillogenesis regulator 1 in paroxysmal nonkinesigenic dyskinesia: confirmation in 2 kindreds
    Dong Hui Chen
    Department of Neurology, University of Washington, Seattle, 98195 7720, USA
    Arch Neurol 62:597-600. 2005
    ..An autosomal dominant form of this disorder was mapped to chromosome 2q33-36, and different missense mutations in exon 1 of the myofibrillogenesis regulator 1 (MR1) gene were identified recently in 2 kindreds...
  87. ncbi Fed-batch culture of Escherichia coli for L-valine production based on in silico flux response analysis
    Jin Hwan Park
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering, BK21 Program, KAIST, Daejeon 305 701, Republic of Korea
    Biotechnol Bioeng 108:934-46. 2011
    ..reported the development of a 100% genetically defined engineered Escherichia coli strain capable of producing L-valine from glucose with a high yield of 0.38 g L-valine per gram glucose (0...
  88. pmc Partitioning of tRNA-dependent editing between pre- and post-transfer pathways in class I aminoacyl-tRNA synthetases
    Morana Dulic
    Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia
    J Biol Chem 285:23799-809. 2010
    ..In both enzymes, the rates of amino acid transfer to tRNA are similar for cognate and noncognate aminoacyl-adenylates, providing a significant contrast with editing DNA polymerases...
  89. ncbi Isolated isobutyryl-CoA dehydrogenase deficiency: an unrecognized defect in human valine metabolism
    C R Roe
    Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Texas
    Mol Genet Metab 65:264-71. 1998
    ..Urine organic acids were normal. In vitro analysis of the mitochondrial pathways for beta oxidation, and leucine, valine, and isoleucine metabolism was performed in fibroblasts using stable isotope-labeled precursors to these pathways ..
  90. ncbi Changes in ventricular size and function in patients treated with valsartan, captopril, or both after myocardial infarction
    Scott D Solomon
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 111:3411-9. 2005
    ....
  91. ncbi Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
    Marc A Pfeffer
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 349:1893-906. 2003
    ..In a double-blind trial, we compared the effect of the angiotensin-receptor blocker valsartan, the ACE inhibitor captopril, and the combination of the two on mortality in this population of patients...
  92. pmc Linking central metabolism with increased pathway flux: L-valine accumulation by Corynebacterium glutamicum
    Eva Radmacher
    Institut fur Biotechnologie, Forschungszentrum Julich, D 52425 Julich, Germany
    Appl Environ Microbiol 68:2246-50. 2002
    ..acetohydroxy acid synthase) and ilvC (which encodes isomeroreductase) in the wild type, which does not excrete L-valine, to result in an accumulation of this amino acid to a concentration of 42 mM...
  93. ncbi Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R
    Osamu Akizuki
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, Shizuoka 411 8731, Japan
    Eur J Pharmacol 584:424-34. 2008
    ..T-type Ca2+ channels may contribute to additional benefits of this drug for treating renal and cardiovascular diseases, beyond its primary anti-hypertensive effects from blocking L-type Ca2+ channels...
  94. ncbi Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design
    Ping Wei
    Drug Discovery Group and Oncology Research Unit, Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California 92121, USA
    Mol Cancer Ther 9:1618-28. 2010
    ..This compound is being investigated for the treatment of T-ALL and advanced solid tumors in phase I clinical trials...
  95. ncbi Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4342-50. 2007
    ..To investigate the involvement of the renin-angiotensin system (RAS) and the nuclear factor (NF)-kappaB pathway with diabetes-induced retinal inflammation...
  96. ncbi BDNF gene is a risk factor for schizophrenia in a Scottish population
    M Neves-Pereira
    Department of Mental Health, University of Aberdeen, Institute of Medical Science, Aberdeen, Scotland AB25 2ZD, UK
    Mol Psychiatry 10:208-12. 2005
    ..The val66met single-nucleotide polymorphism (SNP) showed significant (P = 0.005) association for valine (allele G) with schizophrenia but not bipolar disorder...
  97. pmc Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice
    Banumathi K Cole
    Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Hypertension 55:715-21. 2010
    ..This study suggests that AT1R blockers provide additional therapeutic benefits in the metabolic syndrome and other obesity-related disorders beyond lowering blood pressure...
  98. ncbi Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis
    Steven G Chrysant
    University of Oklahoma, Oklahoma City, OK 73132, USA
    Curr Med Res Opin 24:1039-47. 2008
    ..Here we report the results of a pre-planned 6-month interim analysis of a long-term, open-label study examining the safety, tolerability and efficacy of the aliskiren/valsartan 300/320-mg combination in patients with hypertension...
  99. ncbi Newly diagnosed and previously known diabetes mellitus and 1-year outcomes of acute myocardial infarction: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial
    David Aguilar
    Cardiovascular Division, University of Texas Health Science Center, 6431 Fannin, MSB 1 246, Houston, TX 77030, USA
    Circulation 110:1572-8. 2004
    ..A prior diagnosis of diabetes mellitus is associated with adverse outcomes after acute myocardial infarction (MI), but the risk associated with a new diagnosis of diabetes in this setting has not been well defined...
  100. ncbi Amlodipine and valsartan combined and as monotherapy in stage 2, elderly, and black hypertensive patients: subgroup analyses of 2 randomized, placebo-controlled studies
    Timothy R Smith
    Mercy Health Research, Washington University School of Medicine, St Louis, MO 63141, USA
    J Clin Hypertens (Greenwich) 9:355-64. 2007
    ..These findings were consistent with the primary efficacy analysis results from the overall study populations. Combination regimens were generally well tolerated by all patient subgroups...
  101. pmc Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthood
    Fabio Sambataro
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:540-8. 2009
    ..Among these variations, those related to the dopaminergic system, particularly the valine(158)methionine polymorphism in catechol-O-methyltransferase (COMTval(158)met), have been implicated in modulating ..

Research Grants63

  1. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    ..ARPE-19 cell line) and ex vivo (isolated sclera and RPE-choroid-sclera) models (2) to synthesize ester-peptide (Valine-, Valine-Valine-, Glycine-Valine-, and Tyrosine-Valine-) prodrugs of dexamethasone and prednisolone targeting ..
  2. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    ..A single nucleotide polymorphism, a valine (Val) to methionine (Met) substitution (Val66Met) in the BDNF gene, results in increased mood and cognitive ..
  3. Tumor drug delivery systems based on polymalic acid
    Julia Y Ljubimova; Fiscal Year: 2010
    ..This includes (a) improvement of endosomal disruption activity through enhanced hydrophobicity by exchange of valine in the present carrier with leucine ethylester thereby increasing membrane permeation;(b) exchanging the existing ..
  4. Understanding the Role of COMT Variants in Sensorimotor Gating
    XIANJIN ZHOU; Fiscal Year: 2010
    A single nucleotide polymorphism (SNP), causing a missense mutation of codon 158 Valine to Methionine in the coding region (termed val158met), exists in the human catechol-o-methyltransferase (COMT) gene...
  5. In vivo phenotypic effects of naturally occuring sequence variations in WNV
    Robin M Moudy; Fiscal Year: 2010
    ..has identified a new genotype (WN02) that differs from the introduced genotype (NY99) by a single amino acid, a valine to alanine change at position 159 in the envelope (E) protein...
  6. Extracellular Scaffold Elasticity and Binding Sites in Acinar Differentiation
    Melinda Larsen; Fiscal Year: 2013
    ..IV, collagen type IV;ECM, extracellular matrix;GFP, green fluorescent protein;IKVAV, Isoleucine-Lysine-Valine-Alanine-Valine;PEG, poly(ethylene glycol);PCR, polymerase chain reaction;PEG-DMA, PEG-dimethylacrylate;PEG-TMA, ..
  7. The molecular basis for a broad range of phenotypes related to hTAS2R38
    Sarah V Lipchock; Fiscal Year: 2012
    ..Individuals expressing the amino acid combination proline- alanine-valine (PAV) find compounds with a thiourea moiety, such as 6-n-propylthiouracil (PROP), to be extremely bitter at low ..
  8. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2012
    ..The third forces use of RF2, replacing tyrosine and glycine residues with valine instead of arginine. We created these alleles in BALB/c, and then bred them onto C57BL/6 (N22)...
  9. A novel approach for quantitation of N-terminal valine adducts
    Gunnar Boysen; Fiscal Year: 2012
    ..to redesign the IAC enrichment procedure to enable simultaneous quantitation of a broad spectrum of N-terminal valine adducts...
  10. Elucidating Protein Folding Mechanisms
    Jay R Winkler; Fiscal Year: 2010
    ..Work on Aim 3 involves placement of fluorinated leucine, isoleucine, and valine residues at selected locations in four-helix-bundle proteins with the aim of optimizing and redirecting native ..
  11. Integration of metabolism and virulence in Gram-positive bacteria
    ABRAHAM LINCOLN SONENSHEIN; Fiscal Year: 2013
    ..the intracellular pools of four metabolites, the three branched-chain amino acids (BCAAs;isoleucine, leucine and valine) and GTP. In pathogenic Gram-positive bacteria, CodY is also a major regulator of virulence genes...
  12. Analysis of a Burkholderia mallei Virulence-Associated Type VI Secretion System
    Paul J Brett; Fiscal Year: 2011
    ..Included amongst these are the valine-glycine repeat (VgrG) proteins which have been shown to behave both as structural components of the T6SS machinery ..
  13. ADDUCTS AS QUANTITATIVE MARKERS OF BUTADIENE MUTAGENESIS
    James Swenberg; Fiscal Year: 2009
    ..The second aim is to determine the utility of the N-terminal valine adduct of HMVK (HMVK-Val) as a biomarker of HMVK formation by BD and BD-diol...
  14. Longitudinal Imaging of Frontal Cortex Afferents in a Mouse Model of Anxiety
    LINDA E WILBRECHT; Fiscal Year: 2013
    ..20-30% of Caucasians carry a polymorphism in the BDNF gene, where codon 66 is altered from a valine to methionine (Shimizu et al...
  15. Novel therapeutic targets for Leukemia in Elderly
    Holly Martin; Fiscal Year: 2013
    ..A single point mutation of aspartic acid to valine (KITD816V) in the activation loop of KIT, found in up to 90% of SM patients and ~ 50% of core binding factor AML ..
  16. NMR studies of the effects of mode of birth on vaginal elastin
    Gregory Boutis; Fiscal Year: 2013
    ..The first aim of the proposal is to measure the structural and dynamical properties of lysine, proline, valine, glycine and alanine rich segments of elastin of the vagina following various modes of delivery...
  17. Metabolomic analysis of acute stress hyperglycemia in ischemic stroke
    WILLIAM TAYLOR KIMBERLY; Fiscal Year: 2013
    ..setting of stroke, 2) To determine whether hyperglycemia of stroke influences the way branched chain amino acids (valine, isoleucine and leucine) are altered, and 3) To prospectively investigate whether glucose metabolism and branched ..
  18. COMT Genotype and Executive Function in HIV Infection and Methamphetamine Use
    Ian Paul Everall; Fiscal Year: 2010
    ..We intend to focus on a common functional polymorphism, a Valine (Val) to Methionine (Met) substitution in exon 4 of the gene that alters the amino acid codon at position 108 (..
  19. Mechanisms of Allosteric Influence on Enzymes Activity
    GREGORY DUNCAN REINHART; Fiscal Year: 2012
    ..by analogous methyl-TROSY NMR experiments measuring the side-chain dynamics of leucine, isoleucine, and valine residues...
  20. The development of novel peptidic and peptidomimetic therapies for the treatment
    BRIAN BUERK BRENNAN; Fiscal Year: 2012
    ..point mutation in the gene coding for the [unreadable]-chain of hemoglobin (Hb), leading to the incorporation of a valine surface residue in place of glutamic acid [1]...
  21. Repair of Clustered DNA Damages
    Yoke W Kow; Fiscal Year: 2010
    ..The predominant mutation signature at V599 is T to A transversion mutation (GTG to GAG), changing valine to aspartic acid...
  22. Vitreal delivery of novel AAV vectors for CNGA3 achromatopsia cone gene therapy
    Jijing Pang; Fiscal Year: 2013
    ..model of human achromatopsia with CNGA3 mutations using several novel tyrosine to phenylalanine plus threonine to valine mutant capsid AAV vectors as the gene delivery vehicles for intravitreal injection...
  23. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    ..DQ1 subtype that does not confer susceptibility to PV only at a single position of the DQbeta chain (aspartic acid/valine at DQbeta 57). This disease-associated polymorphism introduces a negative charge into the DQ1 peptide binding site...
  24. Neuregulin 1 signaling and schizophrenia: effect of transmembrane domain variants
    David A Talmage; Fiscal Year: 2012
    ..Several lines of evidence demonstrate that the affected valine residue is essential for gamma secretase mediated NRG1 intramembranous proteolysis and subsequent transcriptional ..
  25. Neuregulin 1 signaling and schizophrenia: effect of transmembrane domain variants
    David A Talmage; Fiscal Year: 2013
    ..Several lines of evidence demonstrate that the affected valine residue is essential for gamma secretase mediated NRG1 intramembranous proteolysis and subsequent transcriptional ..
  26. Ocular Disposition of Antimicrobial Agents
    Ashim K Mitra; Fiscal Year: 2010
    ..of erythromycin, levofloxacin and ofloxacin targeting amino acid (phenylalanine and glutamate prodrugs), peptide (valine, valine-valine and glycine-valine prodrugs) and ascorbate (ascorbic acid prodrugs) transporters expressed on the ..
  27. REACTIVITY MODELS FOR ISOPENICILLIN N SYNTHETASE
    PATRICIA SHAPLEY; Fiscal Year: 1992
    ..enzyme is responsible for the oxidative cyclization of the tripeptide delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N. Iron salts and molecular oxygen are required for activity...
  28. Functional analysis of variant BDNF (Val66Met)
    FRANCIS SANG YONG LEE; Fiscal Year: 2013
    ..nucleotide polymorphism (Val66Met) in the BDNF gene leading to a prodomain substitution at position 66 from a valine (Val) to methionme (Met) has been shown to lead in humans to hippocampal dependent memory impairments and ..
  29. AUTOPHAGY IN GLIA AND NEURONS
    William Dunn; Fiscal Year: 1993
    ..Cultured cells whose proteins have been previously labeled with 14C-valine will be incubated in media with or without amino acids and the release of acid-soluble radioactivity quantified ..
  30. FUNCTIONAL CHARACTERIZATION OF AGT GENETIC POLYMORPHISM
    Jun yan Hong; Fiscal Year: 2001
    ..One missense alteration occurs at the codon 143 (isoleucine to valine)...
  31. ROLE OF HUMAN GST PI POLYMORPHISM IN DRUG RESISTANCE
    Shivendra Singh; Fiscal Year: 2003
    ..which is polymorphic in human populations and involves amino acid residues in positions 104 (isoleucine or valine) and 113 (alanine or valine), is believed to be an important mechanism in tumor cell to alkylating agents...
  32. Immunoglobulin CDR-H3 and neutralizing antibodies to HIV
    Harry Schroeder; Fiscal Year: 2009
    ..where we force use of hydrophobic CDR-H3s by committing B cells to the use of a hydrophobic DH reading frame, valine-enriched DFL16.1 RF2. DFL16.1 is also two to four codons longer than the other mouse DH sequences...
  33. OXYGEN AND SPONTANEOUS MUTAGENESIS IN ESCHERICHIA COLI
    Robert Fowler; Fiscal Year: 1991
    ..facultative aerobic bacterium, Escherichia coli, measurement of forward (LacI-, rifampin resistance and valine resistance) and back (TrpA+) mutation frequencies reveal the proportion of spontaneous mutagenesis that can be ..
  34. NHLBI MINORITY INSTITUTION RESEARCH SCIENTIST DEVELOPMEN
    MARIA DEL PILAR AGUINAGA; Fiscal Year: 2004
    ..Sickle cell disease is caused by the substitution of glutamic acid with valine at the position of amino acid six in the Beta- globin chain...
  35. Poly (amino acid) as an Integrin Targeted Drug Carrier
    Xiaoling Li; Fiscal Year: 2005
    ..It is reported that the recognition of the tripeptide sequence, leucine-aspartic acid-valine, (LDV) is limited only to the a4a1 integrin...
  36. A Mouse Model of Mammalian Shaker Channel RNA Editing
    Tarun Bhalla; Fiscal Year: 2006
    ..RNA editing at this site causes an isoleucine (I) to valine (V) change at a residue important for channel function within the pore-lining $6 domain of Shaker-type K+ channels...
  37. BIOSYNTHESIS OF POLYETHER ANTIBIOTICS
    Charles Hutchinson; Fiscal Year: 1992
    ..We will clone the valine dehydrogenase genes from S. coelicolor and S...
  38. Neuropharmacology of Conophans and Hydroxyconophans
    FRANK MARI; Fiscal Year: 2007
    ..biochemistry as these compounds provide the very first examples ?- hydroxylated modifications of the amino acid Valine. We are uniquely poised to explore this great potential for "Drug discovery" as we posses nanomolar quantities of ..
  39. REGULATING BRANCHED-CHAIN--A-KETOACID DEHYDROGENASE
    R Paxton; Fiscal Year: 1992
    ..Catabolism of these essential amino acids (leucine, valine and isoleucine) is altered by various physiological conditions: diabetes, fasting, obesity and trauma...
  40. COLLABORATIVE STUDY OF 1,3 BUTADIENE BIOMARKERS
    Thomas Smith; Fiscal Year: 2002
    ..of biomarkers show promise for estimating internal dose of epoxybutene and epoxybutanediol; hemoglobin N-terminal valine adducts, lymphocyte 7- alkylguanine DNA adducts, and the urinary mercapturic acid of butenediol...
  41. AMINOKETONE INHIBITORS OF THE DOPAMINE TRANSPORTER
    JOHN REINHARD; Fiscal Year: 2005
    ..g. valine) of either the aminoketone precursor of 1555U88 or of 1555U88 itself...
  42. IMPLICATION OF BRANCHED-CHAIN AMINO AND KETOACIDS
    Mackenzie Walser; Fiscal Year: 1980
    Branched-chain amino acids (valine, leucine and isoleucine) and their nitrogen-free analogues, the branched-chain ketoacids, have become a subject of rapidly increasing interest in recent years...
  43. Understanding the Role of COMT Variants in Sensorimotor Gating
    Victoria Risbrough; Fiscal Year: 2009
    A single nucleotide polymorphism (SNP), causing a missense mutation of codon 158 Valine to Methionine in the coding region (termed val158met), exists in the human catechol-o-methyltransferase (COMT) gene...
  44. CONTROL OF CELL GROWTH, DIFFERENTIATION, AND FUNCTION
    CHARITY WAYMOUTH; Fiscal Year: 1980
    ..The use of D-valine and cis-hydroxyproline for selection against fibroblastic and for epithelial cells, in cultures in defined media, ..
  45. FETAL HB GENE FOR SICKLE CELL AND BETA-THALASSEMIA
    John Haley; Fiscal Year: 1993
    ..The disease results from a glutamic acid to valine change at position 6 of the adult beta-globin gene (Hb to HbS) resulting in an irreversible deformation of red ..
  46. MOLECULAR CHARACTERIZATION OF ACYL-COA DEHYDROGENASES
    Gerard Vockley; Fiscal Year: 2004
    ..in the first step of the B-oxidation of fatty acids and in the intermediate metabolism of leucine, isoleucine and valine. Deficiencies of these enzymes are important causes of inherited defects of metabolism in humans...
  47. NEUTRON DIFFRACTION STUDIES OF VIRUSES
    Lee Makowski; Fiscal Year: 1992
    ..diffraction from specifically deuterated phage particles has been used to determine the positions of the five valine residues in Pf1 in three dimensions...
  48. TRANSFER RNA MIMICRY AND GENOME REPLICATIONS
    Theo Dreher; Fiscal Year: 2000
    ..The goal of this research is to obtain a detailed understanding of the role of a valine-specific TLS that is present at the 3' end of the turnip yellow mosaic virus (TYMV) RNA genome...
  49. TrialNet: University of Florida Clinical Center and Network
    Desmond Schatz; Fiscal Year: 2007
    ..amino acid peptide (Po-102), having the sequence of p277, in which two cysteine residues have been substituted by valine. It has been shown to prevent diabetes in animal models (NOD, streptozotocin-induced) of Type 1 diabetes...
  50. BEDREST AND PROTEIN LOSS IN THE ELDERLY
    T Stein; Fiscal Year: 2000
    ..kg-1.d-1 each of leucine, isoleucine and valine. Protein kinetics (whole body with 1-13C phenylalanine) and muscle (with 15N phenylalanine) and the tissue free ..
  51. Cadmium, K-ras, and Pancreatic Cancer in Egypt
    AMR SOLIMAN; Fiscal Year: 2003
    ..of pancreatic cancer tumors of patients from this region [unusually high rate of GGT --> GTT (glycine --> valine) K-ras mutation]...
  52. Amyloid beta Peptide and Apolipoprotein E
    Thomas Wisniewski; Fiscal Year: 2009
    ..of apoE on Aa (Aa residues 12-28), we synthesized an end-protected, D-amino acid peptide Abeta12-28P, where the valine at residue 18 is substituted by proline...
  53. Toxicological Relevance of Human GST P1-1 Polymorphism
    Shivendra Singh; Fiscal Year: 2005
    ..hGSTPI-1 is polymorphic in human populations, and involves amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine). However, the toxicological relevance of hGSTPI-1 polymorphism is not well defined...
  54. MELANOTIC EXPRESSION IN CARCINOGEN-INDUCED MELANOMAS
    J Whittaker; Fiscal Year: 1980
    ..tyrosinase activity, and tyrosine pool size; rates of growth and metabolism as rates of radioactive thymidine, L-valine, and D-glucose incorporations...
  55. Human Amino Acid Requirements
    Vernon Young; Fiscal Year: 2004
    ..dietary tyrosine on the requirement for phenylaIanine alone; 5) to confirm the predictions of the requirements for valine as derived from the requirements for leucine; 6) to examine the consequences of adaptation to a low lysine and low ..
  56. TRIPLEX BASED REPAIR OF THE SICKLE CELL MUTATION
    JACQUES FRESCO; Fiscal Year: 2003
    ..This malformation is the result of a single amino acid substitution (glutamic -> acid valine) at position 6 of the beta-globin chain, which, in turn, is due to an A ->T transversion mutation on chromosome ..
  57. EXPRESSION OF IMMUNOGLOBULIN GENES
    Ursula Storb; Fiscal Year: 2005
    ..Previous findings suggest that a point mutation in the lambda1 constant region changing a glycine to a valine codon may be responsible...
  58. PROTEIN BIOSYNTHESIS AS A FUNCTION OF AGE OR CANCER
    ROBERT LOFTFIELD; Fiscal Year: 1980
    ..Previous experiments have shown that (3H)valine substitutes for threonine and isoleucine to the extent of about .03%...
  59. Characterization of FOXO3A 419T Variant in Fragile X Premutation-Related POF
    Stephen Collins; Fiscal Year: 2009
    ..The 419T variant causes an alanine to valine substitution at amino acid 140, a residue conserved in mammals, and therefore is likely to alter FOXO3A function...
  60. MICROELECTRODES FOR THE DETERMINATION OF NEUROREGULATORS
    GLENN LUBRANO; Fiscal Year: 1992
    ..acid (GABA), choline, acetylcholine, glycine and the amino acids glutamine, histidine, alanine, asparagine, valine, isoleucine, leucine, arginine, methionine, tryptophan and phenylalanine, which are possible neurotransmitters...
  61. ENZYMIC MECHANISMS IN BIOSYNTHETIC PATHWAYS
    H Umbarger; Fiscal Year: 1991
    ..The system currently studied consists of the pathways to isoleucine and valine in bacteria...
  62. UNIQUE PROTEIN AND ENERGY DEMANDS OF SICKLE CELL DISEASE
    Paul Flakoll; Fiscal Year: 2000
    ..disorder Characterized by the sickling of red blood cells (RBC) due to the replacement of glutamic acid with valine in position 6 on the beta chains of hemoglobin...
  63. AB INITIO STUDIES OF BIOMOLECULES
    Alice Chung Phillips; Fiscal Year: 2000
    ..Conformational potential energy surfaces around the low energy minima of glycine, alanine, serine, valine, and threonine will be calculated for internal rotations about the single bonds of alpha- and beta-carbon atoms in ..