omega n methylarginine

Summary

Summary: A competitive inhibitor of nitric oxide synthetase.

Top Publications

  1. ncbi The contribution of nitric oxide to exercise hyperemia in the human forearm
    Mary Beth Gordon
    Harvard Medical School 03, Boston, MA, USA
    Vasc Med 7:163-8. 2002
  2. ncbi beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine
    Markus P Schlaich
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, Melbourne, Australia
    J Hypertens 22:1917-25. 2004
  3. ncbi Nitric oxide- and EDHF-mediated arteriolar tone in uremia is unaffected by selective inhibition of vascular cytochrome P450 2C9
    Jens Passauer
    Division of Nephrology, Department of Medicine, University Hospital Carl Gustav Carus, Dresden, Germany
    Kidney Int 67:1907-12. 2005
  4. ncbi Interaction between nitric oxide and the cholinergic and sympathetic nervous system in cardiovascular control in humans
    Claudio Sartori
    Botnar Center for Clinical Research, Department of Internal Medicine, BH 10 642, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Pharmacol Ther 106:209-20. 2005
  5. ncbi Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
    Petra Kleinbongard
    Department of Medicine, Division of Cardiology, Pulmonary Diseases, Angiology, Heinrich Heine University, Duesseldorf, Germany
    Free Radic Biol Med 35:790-6. 2003
  6. ncbi Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover study
    N Tzemos
    Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Circulation 104:511-4. 2001
  7. ncbi Prostaglandins are involved in acetylcholine- and 5-hydroxytryptamine-induced, nitric oxide-mediated vasodilatation in human forearm
    Adriaan M Kamper
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Pharmacol 40:922-9. 2002
  8. ncbi Endogenous estrogen mediates vascular reactivity and distensibility in pregnant rat mesenteric arteries
    Y Zhang
    Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Am J Physiol Heart Circ Physiol 280:H956-61. 2001
  9. ncbi Enhanced endothelium-dependent vasodilation in Fabry disease
    G Altarescu
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1260, USA
    Stroke 32:1559-62. 2001
  10. ncbi Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure
    Matthias Schmitt
    Wales Heart Research Institute, Cardiff, UK
    Arterioscler Thromb Vasc Biol 24:911-7. 2004

Research Grants

  1. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
  2. IN VIVO MECHANICAL LOADING EARLY RESPONSE GENES
    Diane Cullen; Fiscal Year: 2000
  3. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2006
  4. Cerebrovascular Disease in Type 1 Diabetes
    WILLIAM MAYHAN; Fiscal Year: 2007
  5. Cerebral Microcirculation During Alcohol Consumption
    WILLIAM MAYHAN; Fiscal Year: 2008
  6. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
  7. Endothelial Abnormalities in Obesity/Insulin Resistance
    CHRISTOPHER DESOUZA; Fiscal Year: 2005
  8. MMP-9-Dependent Vessel Wall Remodeling is NO-Dependent
    Gilbert Upchurch; Fiscal Year: 2005
  9. Urine protein markers of disease in lupus nephritis
    James Oates; Fiscal Year: 2005
  10. Host Factors in Susceptibility to Chlamydial Disease
    KYLE RAMSEY; Fiscal Year: 2006

Detail Information

Publications223 found, 100 shown here

  1. ncbi The contribution of nitric oxide to exercise hyperemia in the human forearm
    Mary Beth Gordon
    Harvard Medical School 03, Boston, MA, USA
    Vasc Med 7:163-8. 2002
    ..This study indicates that NO is not a major regulator of peak limb blood flow measured immediately after cessation of dynamic exercise. The contribution of NO to exercise hyperemia is limited to the recovery period after exercise...
  2. ncbi beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine
    Markus P Schlaich
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, Melbourne, Australia
    J Hypertens 22:1917-25. 2004
    ..It is unknown whether beta-adrenoceptor-mediated vasodilatation is altered in early hypertension and whether it can be modulated by L-arginine...
  3. ncbi Nitric oxide- and EDHF-mediated arteriolar tone in uremia is unaffected by selective inhibition of vascular cytochrome P450 2C9
    Jens Passauer
    Division of Nephrology, Department of Medicine, University Hospital Carl Gustav Carus, Dresden, Germany
    Kidney Int 67:1907-12. 2005
    ..We therefore determined whether one of these pathways is involved in endothelial dysfunction of uremia...
  4. ncbi Interaction between nitric oxide and the cholinergic and sympathetic nervous system in cardiovascular control in humans
    Claudio Sartori
    Botnar Center for Clinical Research, Department of Internal Medicine, BH 10 642, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Pharmacol Ther 106:209-20. 2005
    ....
  5. ncbi Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
    Petra Kleinbongard
    Department of Medicine, Division of Cardiology, Pulmonary Diseases, Angiology, Heinrich Heine University, Duesseldorf, Germany
    Free Radic Biol Med 35:790-6. 2003
    ..These results provide evidence for a uniform constitutive vascular NOS-activity across mammalian species...
  6. ncbi Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover study
    N Tzemos
    Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Circulation 104:511-4. 2001
    ..We hypothesized that nebivolol, a vasodilating beta-blocker, could improve endothelial dysfunction. We tested this hypothesis by comparing the effects of nebivolol and atenolol on endothelial function...
  7. ncbi Prostaglandins are involved in acetylcholine- and 5-hydroxytryptamine-induced, nitric oxide-mediated vasodilatation in human forearm
    Adriaan M Kamper
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Cardiovasc Pharmacol 40:922-9. 2002
    ..It is concluded that in the human forearm, the prostaglandin pathway is involved in both the Ach- and 5HT-induced NO-mediated vasodilatation...
  8. ncbi Endogenous estrogen mediates vascular reactivity and distensibility in pregnant rat mesenteric arteries
    Y Zhang
    Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Am J Physiol Heart Circ Physiol 280:H956-61. 2001
    ..05) compared with nonpregnant and tamoxifen-treated pregnant animals. In summary, endogenous estrogen during pregnancy increases NO-dependent modulation of vessel tone and arterial distensibility...
  9. ncbi Enhanced endothelium-dependent vasodilation in Fabry disease
    G Altarescu
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1260, USA
    Stroke 32:1559-62. 2001
    ..The increased vessel response to acetylcholine with and without L-NMMA suggests altered functionality of non-NO endothelium-dependent vasodilatory pathways...
  10. ncbi Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure
    Matthias Schmitt
    Wales Heart Research Institute, Cardiff, UK
    Arterioscler Thromb Vasc Biol 24:911-7. 2004
    ....
  11. ncbi Nitric oxide mediates abnormal responsiveness of thyroid arteries in methimazole-treated patients
    Joaquin Ortega
    Department of Surgery, Hospital Clínico Research Unit, University of Valencia, Spain
    Eur J Endocrinol 152:551-6. 2005
    ..We studied the intervention of nitric oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor (EDHF) in mediating responses to acetylcholine in thyroid arteries from euthyroid and methimazole-treated (MT) patients...
  12. ncbi Endogenous nitric oxide attenuates beta-adrenoceptor-mediated relaxation in rat aorta
    Khong Bee Kang
    School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 34:95-101. 2007
    ..The lack of cAMP participation in endothelium-intact vessels may be because NO suppresses or overrides the cAMP effect...
  13. ncbi Divergent biological actions of coronary endothelial nitric oxide during progression of cardiac hypertrophy
    D J Grieve
    Department of Cardiology, Guy's, King's and St Thomas' School of Medicine, King's College London (Denmark Hill Campus, London, United Kingdom
    Hypertension 38:267-73. 2001
    ....
  14. ncbi Age-related reduction of NO availability and oxidative stress in humans
    S Taddei
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 38:274-9. 2001
    ..These alterations are similar but anticipated in hypertensive patients compared with normotensive subjects...
  15. pmc Endothelium-dependent NO-mediated vasodilation in humans is attenuated by peripheral alpa1-adrenoceptor activation
    Adriaan M Kamper
    Department of Gerontology, Leiden University Medical Center, Leiden, The Netherlands
    Vasc Health Risk Manag 1:251-6. 2005
    ..The aim of the present study was to examine the effect of alpha1- and alpha2-adrenoceptor activation on nitric oxide-mediated vasodilation...
  16. ncbi Exercise training enhances vasodilation responses to vascular endothelial growth factor in porcine coronary arterioles exposed to chronic coronary occlusion
    Jennifer A Fogarty
    Cardiovascular Research Institute and Department of Medical Physiology, Texas A and M University System Health Science Center, College Station, Tex 77843 1114, USA
    Circulation 109:664-70. 2004
    ..We hypothesized that EX enhances vasodilation responses to vascular endothelial growth factor (VEGF165), mediated via nitric oxide (NO), in arterioles exposed to CCO...
  17. ncbi Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:3731-7. 2003
    ..Patients with sHT are characterized by endothelial dysfunction resulting from a reduction in NO availability, an alteration partially independent of dyslipidemia and reversed by levothyroxine supplementation...
  18. ncbi Repetition of ischemic preconditioning augments endothelium-dependent vasodilation in humans: role of endothelium-derived nitric oxide and endothelial progenitor cells
    Masashi Kimura
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Mimami ku, Hiroshima 734 8551, Japan
    Arterioscler Thromb Vasc Biol 27:1403-10. 2007
    ..Several studies have shown that both early and late effects of ischemic preconditioning (IPC) protect against myocardial injury after ischemic reperfusion...
  19. ncbi Effects of the reactive oxygen species hydrogen peroxide and hypochlorite on endothelial nitric oxide production
    E A Jaimes
    Nephrology and Hypertension Section, Veterans Administration Medical Center, Minneapolis, Minnesota, USA
    Hypertension 38:877-83. 2001
    ....
  20. ncbi Influence of acute and chronic mineralocorticoid excess on endothelial function in healthy men
    Fabian Nietlispach
    Clinic of Cardiology, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Hypertension 50:82-8. 2007
    ....
  21. ncbi Nitric oxide release is impaired in hypertensive individuals with familial history of stroke
    Francesco Cosentino
    Division of Cardiology, 2 nd Faculty of Medicine, University La Sapienza, Rome, Italy
    Am J Hypertens 19:1213-6. 2006
    ..We aimed to investigate whether impairment of endothelium-dependent vasodilation can be used as an informative intermediate vascular phenotype in hypertensive patients with familial history of stroke...
  22. ncbi Infliximab improves endothelial dysfunction in systemic vasculitis: a model of vascular inflammation
    A D Booth
    Clinical Pharmacology Unit, University of Cambridge, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Circulation 109:1718-23. 2004
    ....
  23. ncbi Calcium-independent release of endothelial nitric oxide in the arteriolar network: onset during rapid juvenile growth
    Timothy R Nurkiewicz
    Department of Physiology and Pharmacology, and the Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, West Virginia, USA
    Microcirculation 11:453-62. 2004
    ..The aim of this study was to determine if, in general, signaling pathways for endothelial NO release that differ in their reliance on Ca2+ may be developing at different times during normal arteriolar network growth in skeletal muscle...
  24. ncbi Reduced agonist-induced endothelium-dependent vasodilation in uremia is attributable to an impairment of vascular nitric oxide
    Jens Passauer
    Division of Nephrology, Department of Medicine, University Hospital Carl Gustav, Dresden, Germany
    J Am Soc Nephrol 16:959-65. 2005
    ....
  25. pmc Carvedilol improves endothelium-dependent vasodilation in patients with dilated cardiomyopathy
    Kenji Nishioka
    Heart 93:247-8. 2007
  26. pmc Preserved contribution of nitric oxide to baseline vascular tone in deconditioned human skeletal muscle
    Michiel W P Bleeker
    Department of Pharmacology Toxicology 233, Radboud University Nijmegen Medical Centre, Geert Grooteplein Noord 21, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Physiol 565:685-94. 2005
    ..In conclusion, two human in vivo models of deconditioning show a preserved baseline NO availability in the leg skeletal muscle vascular bed...
  27. ncbi Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases
    M B Hussain
    Centre for Clinical Pharmacology, The Rayne Institute, University College London, London WC1E 6JJ, United Kingdom
    Am J Physiol Heart Circ Physiol 280:H1151-9. 2001
    ..This cooperative interaction between NO and ANP may have important implications for human pathophysiologies involving deficiency in either mediator and the clinical use of nitrovasodilators...
  28. ncbi The phytoestrogen genistein produces acute nitric oxide-dependent dilation of human forearm vasculature with similar potency to 17beta-estradiol
    H A Walker
    Cardiothoracic Centre, St Thomas' Hospital, London, UK
    Circulation 103:258-62. 2001
    ..CONCLUSIONS: Genistein causes L-arginine/NO-dependent vasodilation in forearm vasculature of human subjects with similar potency to 17beta-estradiol and potentiates endothelium-dependent vasodilation to acetylcholine...
  29. ncbi Relative significance of the nitric oxide (NO)/cGMP pathway and K+ channel activation in endothelium-dependent vasodilation in the femoral artery of developing piglets
    R Støen
    Department of Pediatrics, University Hospital, 7006 Trondheim, Norway
    Acta Physiol Scand 171:29-35. 2001
    ..Lower sensitivity to NOS inhibition and a larger increase in cGMP in response to ACh could indicate a higher efficacy of the NO/cGMP pathway in this vessel in the newborn piglet...
  30. ncbi Calcium-activated potassium channels and NO regulate human peripheral conduit artery mechanics
    Jeremy Bellien
    Departement de Pharmacologie, Rouen University Hospital, France
    Hypertension 46:210-6. 2005
    ..Moreover, the synergistic effect of l-NMMA and TEA shows that KCa channels compensate for the loss of NO synthesis to maintain peripheral conduit artery diameter and mechanics...
  31. ncbi Adrenomedullin causes coronary vasodilation in humans: effects of inhibition of nitric oxide synthesis
    Kentaro Ueda
    Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Cardiovasc Pharmacol 46:534-9. 2005
    ..These findings suggest that adrenomedullin dilates human coronary arteries through an increase in NO production, at least in part...
  32. ncbi Role of nitric oxide in methacholine-induced sweating and vasodilation in human skin
    Kichang Lee
    John B Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut, USA
    J Appl Physiol 100:1355-60. 2006
    ....
  33. ncbi Preservation of venous endothelial function in the forearm venous capacitance bed of patients with chronic heart failure despite arterial endothelial dysfunction
    A K Nightingale
    Department of Cardiology, University of Wales College of Medicine, Cardiff, United Kingdom
    J Am Coll Cardiol 37:1062-8. 2001
    ..This may provide important insights into mechanisms of endothelial dysfunction in CHF and the potential for novel therapy...
  34. ncbi Exploring vascular benefits of endothelium-derived nitric oxide
    John R Cockcroft
    Department of Cardiology, Wales Heart Research Institute, Cardiff University, Cardiff, United Kingdom
    Am J Hypertens 18:177S-183S. 2005
    ....
  35. ncbi Role of Cu,Zn-SOD in the synthesis of endogenous vasodilator hydrogen peroxide during reactive hyperemia in mouse mesenteric microcirculation in vivo
    Toyotaka Yada
    Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192 Japan
    Am J Physiol Heart Circ Physiol 294:H441-8. 2008
    ..Endothelial Cu,Zn-SOD plays an important role in the synthesis of endogenous H(2)O(2) that contributes to RH in mouse mesenteric smaller arterioles...
  36. ncbi Periodontal infection is associated with endothelial dysfunction in healthy subjects and hypertensive patients
    Yukihito Higashi
    Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Hypertension 51:446-53. 2008
    ....
  37. ncbi Kidney transplantation improves endothelium-dependent vasodilation in patients with endstage renal disease
    Jens Passauer
    Universitatsklinikum Carl Gustav Carus, Technische Universitat Dresden, Medizinische Klinik III Nephrologie, Fetscherstr 74, 01307 Dresden, Germany
    Transplantation 75:1907-10. 2003
    ..01), remained unchanged after Tx. N-monomethyl-L-arginine and norepinephrine comparably reduced forearm blood flow in all groups. This is the first evidence showing an improvement of endothelial dysfunction in HD patients after Tx...
  38. pmc Increased inflammatory activity parallels increased basal nitric oxide production and blunted response to nitric oxide in vivo in rheumatoid arthritis
    H Yki-Jarvinen
    Department of Medicine, Divisions of Diabetes, University of Helsinki, Helsinki, Finland
    Ann Rheum Dis 62:630-4. 2003
    ..Endothelial dysfunction, defined as loss of bioactivity of NO in the vessel wall, is thought to precede atherosclerosis...
  39. ncbi Nitric oxide plays an insignificant role in direct vasodilator effects of calcium channel blockers in healthy humans
    Motoyuki Nakamura
    Second Department of Internal Medicine, Iwate Medical University, Morioka, Japan
    Heart Vessels 16:105-10. 2002
    ..In conclusion, direct NO liberation does not make a significant contribution to the vasodilation associated with first-generation CCBs in healthy human resistance vessels...
  40. ncbi Endothelium-dependent responses in coronary arteries are changed with puberty in male pigs
    Ritu Chatrath
    Division of Pediatric Cardiology, Department of Surgery, Mayo Clinic Rochester, 200 First Street S W, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 285:H1168-76. 2003
    ..In addition, endothelium-derived inhibitory cyclooxygenase products seem to predominate in juveniles...
  41. ncbi Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects
    Nikolaj Ihlemann
    Department of Cardiology, Bldg 40, Bispebjerg University Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen, Denmark
    Am J Physiol Heart Circ Physiol 285:H875-82. 2003
    ..0001). An oral glucose challenge causes transient, NO-specific, endothelial dysfunction, which may be reversed by BH4. Transient postprandial endothelial dysfunction may be partly explained by reduced bioavailability of BH4 and NO...
  42. ncbi PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers
    Masashi Kimura
    Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Hypertension 41:1106-10. 2003
    ....
  43. ncbi Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production
    Filippo Mariano
    Department of Area of Medicine, Nephrology and Dialysis Unit, CTO Hospital, Turin, Italy
    Shock 19:339-44. 2003
    ..The synthesis of PAF was enhanced by combined treatment with L-NAME and TNF or LPS. These results indicate an inhibitor effect of NO on the spontaneous and TNF or LPS-induced synthesis of PAF by human PMN, MO, and EC...
  44. ncbi Influence of nitric oxide on neurogenic contraction and relaxation of the human gastroepiploic artery
    Pascual Medina
    Departamento de Fisiologia, Facultad de Medicina y Odontologia, Universidad de Valencia, Valencia, Spain
    Am J Hypertens 16:28-32. 2003
    ..The objective of this study was to characterize the neurogenic contraction and relaxation of the human gastroepiploic artery and to determine whether the responses are mediated by nitric oxide (NO) from neural or endothelial origin...
  45. ncbi Endothelial NO formation does not control myocardial O2 consumption in mouse heart
    Zvezdana Z Kojic
    Institut für Herz und Kreislaufphysiologie, Heinrich Heine Universitat Dusseldorf, Postfach 10 10 07, 40001 Dusseldorf, Germany
    Am J Physiol Heart Circ Physiol 285:H392-7. 2003
    ..Because BK-induced stimulation of endothelial NO formation and basal NO are not sufficient to impair MVO2 in the saline-perfused mouse heart, a tonic control of the respiratory chain by endothelial NO is difficult to conceive...
  46. pmc Enhanced vasodilatation to endothelin antagonism in patients with compensated cirrhosis and the role of nitric oxide
    A Helmy
    Liver Unit, Department of Medicine, Royal Infirmary of Edinburgh, and Clinical Pharmacology Unit and Research Centre, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Gut 52:410-5. 2003
    ....
  47. ncbi Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm
    Nivedita Singh
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    Clin Sci (Lond) 102:595-600. 2002
    ..Defects in both pathways could contribute to the development of age-related cardiovascular disease...
  48. pmc Flow-mediated nitric oxide activity in the forearm vasculature of premenopausal women
    Dilly O C Anumba
    Departments of Obstetrics and Gynaecology, University of Newcastle upon Tyne, NE1 4LP UK
    Br J Clin Pharmacol 53:332-6. 2002
    ..Nitric oxide (NO) is involved in acute flow-mediated vasodilatation in various vascular beds. We determined whether acutely increasing flow in the human forearm of premenopausal women increases vascular NO activity...
  49. ncbi Relative contribution of vasodilator prostanoids, NO, and KATP channels to human forearm metabolic vasodilation
    H M Omar Farouque
    Cardiovascular Research Centre, Monash Medical Centre and Monash University, Melbourne 3168, Victoria, Australia
    Am J Physiol Heart Circ Physiol 284:H2405-11. 2003
    ..05). Addition of glibenclamide to l-NMMA and aspirin did not further decrease FHBF. Vascular K(ATP) channel blockade with glibenclamide does not affect resting FBF or FHBF in the setting of NO and vasodilator prostanoid inhibition...
  50. ncbi Nitric oxide mediates protective effect of endothelin receptor antagonism during myocardial ischemia and reperfusion
    Adrian T Gonon
    Department of Cardiology, Karolinska Hospital, 171 76 Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 286:H1767-74. 2004
    ..In conclusion, the dual ETA/ETB receptor antagonist bosentan preserved endothelial and cardiac contractile function during ischemia and reperfusion via a mechanism dependent on endothelial NO production...
  51. ncbi Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease
    Stephan Fichtlscherer
    Departments of Internal Medicine IV, Division of Cardiology, Johann W Goethe University, Frankfurt am Main, Germany
    Circulation 109:178-83. 2004
    ..Here, we studied the involvement of CYP 2C9 in modulating endothelium-dependent and -independent changes in forearm blood flow (FBF) in healthy volunteers and in patients with manifest coronary artery disease...
  52. ncbi Endothelial dysfunction of coronary resistance vessels in apoE-/- mice involves NO but not prostacyclin-dependent mechanisms
    Axel Gödecke
    Institut für Herz und Kreislaufphysiologie, Heinrich Heine Universitat Dusseldorf, Postfach 101007, 40001 Dusseldorf, Germany
    Cardiovasc Res 53:253-62. 2002
    ..We have analyzed the extent of endothelial dysfunction in cardiac resistance vessels of hyperlipidaemic apoE-/- mice and explored whether NO and/or prostacyclin dependent pathways are involved...
  53. ncbi The effect of nitric oxide on acetylcholine release in the rabbit bladder
    Y Miyamoto
    Department of Urology, Kumamoto University School of Medicine, Honjo, Japan
    Eur J Pharmacol 428:59-67. 2001
    ..The results suggest that there is a NO-mediated mechanism inhibiting acetylcholine release from cholinergic nerve endings in rabbit bladder, which may contribute to bladder function...
  54. ncbi Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide
    S N Doshi
    Department of Pharmacology, Cardiovascular Sciences Research Group, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Clin Sci (Lond) 101:629-35. 2001
    ..FMD following wrist occlusion may be a more valid marker of endothelial function than dilatation following upper arm occlusion...
  55. ncbi Ca2+-activated K+ channels mediate relaxation of forearm veins in chronic renal failure
    Juan B Martínez-León
    Department of Surgery, Research Unit, Hospital Clinico Universitario, University of Valencia, School of Medicine, Valencia, Spain
    J Hypertens 21:1927-34. 2003
    ..In arteries, agonists such as acetylcholine release an endothelium-derived hyperpolarizing factor (EDHF) that is neither nitric oxide nor prostacyclin...
  56. ncbi The effect of nitric oxide synthase and cyclooxygenase inhibition on cutaneous microvascular reactivity
    Helena Lenasi
    Institute of Physiology, School of Medicine, University of Ljubljana, Zaloska 4, Ljubljana, Slovenia
    Eur J Appl Physiol 103:719-26. 2008
    ..8 +/- 70.5% in control vs. 733.5 +/- 54.6% in the treated site). These findings indicate that NO- and PGI(2)-independent mechanism plays an important role in the regulation of blood flow in the human skin microcirculation...
  57. ncbi Platelet glycoprotein IIb/IIIa receptor blockade improves vascular nitric oxide bioavailability in patients with coronary artery disease
    Thomas Heitzer
    Universitatsklinikum Hamburg Eppendorf, Medizinische Klinik III, Abteilung Kardiologie und Angiologie, Martinistrasse 52, 20246 Hamburg, Germany
    Circulation 108:536-41. 2003
    ..The present study was designed to determine whether glycoprotein IIb/IIIa receptor blockade influences endothelial vasomotor function and NO bioactivity in patients with coronary artery disease...
  58. pmc Quantitative aspects of the inhibition by N(G)-monomethyl-L-arginine of responses to endothelium-dependent vasodilators in human forearm vasculature
    M Dawes
    Department of Clinical Pharmacology, St Thomas' Hospital and Centre for Cardiovascular Biology and Medicine, King's College, London SE1 7EH
    Br J Pharmacol 134:939-44. 2001
    ....
  59. ncbi Role of propofol and its solvent, intralipid, in nitric oxide-induced peripheral vasodilatation in dogs
    M F Doursout
    Department of Anesthesiology, University of Texas Houston Medical School, 6431 Fannin, MSB 5 020 Houston, TX 77030 1503, USA
    Br J Anaesth 89:492-8. 2002
    ..Both propofol and its solvent seem to stimulate the nitric oxide (NO) pathway. The role of intralipid in cardiac and regional haemodynamic changes induced by propofol and their respective interactions with the NO pathway was assessed...
  60. pmc Characterization of the 5-HT receptor mediating endothelium-dependent relaxation in porcine vena cava
    M J Sumner
    Peripheral Pharmacology Department, Glaxo Group Research, Ware, Hertfordshire
    Br J Pharmacol 102:938-42. 1991
    ..The characteristics of this receptor are discussed in relation to the endothelial 5-HT receptor types in other blood vessels...
  61. pmc Endothelium-dependent relaxation to acetylcholine in the rabbit basilar artery: importance of membrane hyperpolarization
    V E Rand
    Department of Physiology and Pharmacology, University of Southampton
    Br J Pharmacol 106:143-50. 1992
    ..They indicate that nitric oxide is involved in both of these responses, but that the smooth muscle hyperpolarization is not an essential component of the relaxation...
  62. pmc Characterization of the receptor mediating relaxation to substance P in canine middle cerebral artery: no evidence for involvement of substance P in neurogenically mediated relaxation
    C M Stubbs
    Department of Neuropharmacology, Glaxo Group Research, Ware, Herts
    Br J Pharmacol 105:875-80. 1992
    ..However, substance P does not appear to be involved in NANC neurotransmission. In contrast, the marked inhibitory effect of L-NMMA on NANC relaxations implicates nitric oxide in NANC neurotransmission in this vessel...
  63. ncbi Mechanisms of cytokine induced bone resorption: role of nitric oxide, cyclic guanosine monophosphate, and prostaglandins
    S H Ralston
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Foresterhill, UK
    Bone 19:29-33. 1996
    ....
  64. ncbi Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase
    R Rajpurohit
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140
    J Biol Chem 269:1075-82. 1994
    ....
  65. pmc Growth hormone-releasing factor increases somatostatin release and mRNA levels in the rat periventricular nucleus via nitric oxide by activation of guanylate cyclase
    M C Aguila
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235 8873
    Proc Natl Acad Sci U S A 91:782-6. 1994
    ..The nitric oxide diffuses to the adjacent SRIF neurons, where it activates guanylate cyclase, leading to increased formation of cGMP. This cGMP increases SRIF mRNA and SRIF release in the periventricular nuclei of male rats...
  66. ncbi Influence of dipyridamole and its combination with NO donor or NO synthase inhibitor on adjuvant arthritis
    Adel Gomaa
    Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al madinah Almunawwarah, KSA
    Int Immunopharmacol 10:1406-14. 2010
    ..A synergistic combination between dipyridamole and NO synthase inhibitor or low dose of NO donor may have prophylactic and therapeutic values in autoimmune diseases like RA...
  67. ncbi RNase treatment of yeast and mammalian cell extracts affects in vitro substrate methylation by type I protein arginine N-methyltransferases
    A Frankel
    Department of Chemistry and Biochemistry and Molecular Biology Institute, UCLA, Los Angeles, California 90095 1569, USA
    Biochem Biophys Res Commun 259:391-400. 1999
    ..These results suggest that the methylation and RNA-binding of GAR domain-containing proteins in vivo may regulate protein-nucleic acid or protein-protein interactions...
  68. ncbi Leukotoxin (9, 10-epoxy-12-octadecenoate) impairs energy and redox state of isolated perfused rat lung
    M Akai
    Third Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Japan
    Free Radic Biol Med 25:596-604. 1998
    ..These findings indicate that Lx shifted the lung redox state toward oxidation and that Lx-induced lung injury was involved in the imbalance of the energy and redox state via production of nitric oxide and/or superoxide anion...
  69. pmc Nitric oxide and sensory nerves are involved in the vasodilator response to acetylcholine but not calcitonin gene-related peptide in rat skin microvasculature
    V Ralevic
    National Research Institute of Gerontology and Geriatric Medicine, North West Hospital Mount Royal Campus, Parkville, Australia
    Br J Pharmacol 106:650-5. 1992
    ..The vasodilator mediator(s) released by ACh from sensory nerves acts largely independently of NO.7. The vasodilator response to CGRP is independent of a prejunctional action on sensory nerves and of NO...
  70. ncbi Role of nitric oxide in leukotriene C4-induced increases in microvascular transport
    W G Mayhan
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha 68198 4575
    Am J Physiol 265:H409-14. 1993
    ....
  71. pmc Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay
    W K Alderton
    Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK
    Biochem J 332:195-201. 1998
    ..The kinetics of interaction with tetrahydrobiopterin were complex, showing a triphasic binding process and a single off rate. An alternating catalytic site mechanism for NOS is proposed...
  72. ncbi Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line
    C R Lyons
    Howard Hughes Medical Institute, Brigham and Women s Hospital, Boston, Massachusetts
    J Biol Chem 267:6370-4. 1992
    ....
  73. pmc Studies on NG-methylarginine derivatives in myelin basic protein from developing and mutant mouse brain
    N Rawal
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140
    Biochem J 287:929-35. 1992
    ..These results therefore indicate that structural integrity of myelin membrane in which MBP is embedded appears to play a pivotal role in determining the extent and the kind of Me2Arg formation in MBP at the post-translational level...
  74. ncbi The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, UK
    Cardiovasc Res 38:485-92. 1998
    ..Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man...
  75. pmc Interleukin 1beta decreases prostacyclin synthase activity in rat mesangial cells via endogenous peroxynitrite formation
    M H Zou
    Faculty of Biology, University of Konstanz, Fach X910 Sonnenbühl, D 78434 Konstanz, Germany
    Biochem J 336:507-12. 1998
    ..Taken together, our results strongly suggest that IL-1beta pretreatment of RMC via NOS-2 leads to the production of PON with the consequence of a partial nitration and inhibition of PGIS...
  76. ncbi Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4
    Ted M Lakowski
    Division of Biomolecular and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC V6T1Z3, Canada
    Biochem J 421:253-61. 2009
    ..Although PRMT2 activity is substantially lower than PRMT1 in vitro, the fact that both enzymes selectively methylate histone H4 suggest that PRMT2, like PRMT1, may act as a transcription co-activator through this modification...
  77. pmc Endogenous nitric oxide modulates adrenergic neural vasoconstriction in guinea-pig pulmonary artery
    S F Liu
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 104:565-9. 1991
    ..Basal release of nitric oxide from endothelial cells may account for this inhibition...
  78. ncbi Peripheral vascular tone in patients with cirrhosis: role of the renin-angiotensin and sympathetic nervous systems
    D E Newby
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Scotland, UK
    Cardiovasc Res 38:221-8. 1998
    ..The aims of the study were to establish the roles of angiotensin II and of the cardiopulmonary baroreceptor reflex in the regulation of peripheral vascular tone in patients with cirrhosis...
  79. ncbi Ouabain enhances basal release of nitric oxide from carotid artery
    J Xie
    Department of Medicine, Louisiana State University Medical Center, New Orleans 70112
    Am J Med Sci 305:157-63. 1993
    ..Speculatively, ouabain-induced stimulation of NO release from vascular endothelium may contribute to the beneficial effect of ouabain in congestive heart failure...
  80. ncbi Comparison of P2 receptor subtypes producing dilation in rat intracerebral arterioles
    Tetsuyoshi Horiuchi
    Department of Neurosurgery, Washington University School of Medicine, Box 8057, 660 S Euclid Ave, St Louis, MO 63110, USA
    Stroke 34:1473-8. 2003
    ..We investigated the effects of activating P2Y1 and P2Y2 receptors and their underlying dilator mechanisms in rat intracerebral arterioles...
  81. ncbi Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion
    Veronika Jenei
    Department of Laboratory Medicine, Division of Experimental Pathology, Lund University, Malmo University Hospital, SE 20502 Malmo, Sweden
    J Biol Chem 281:35008-20. 2006
    ..Thus, we made the novel findings that beta2 integrin engagement on human neutrophils triggers production of nitric oxide and its downstream signaling is essential for activation of Rap GTPases and neutrophil adhesion...
  82. ncbi Nitric oxide production by Leishmania-infected macrophages and modulation by cytokines and prostaglandins
    O Brandonisio
    Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, Sezione di Microbiologia ed Immunologia, Facolta di Medicina e Chirurgia, Universita di Bari, Policlinico, Piazza G Cesare, 70124 Bari, Italy
    Parassitologia 43:1-6. 2001
    ..These results are interesting in the light of a possible immunological or pharmacological regulation of NO synthesis and microbicidal functions of macrophages...
  83. ncbi Melatonin suppresses homocysteine enhancement of serotonin-induced vasoconstriction in the human umbilical artery
    Y Okatani
    Department of Obstetrics and Gynecology, Kochi Medical School, Kochi, Japan
    J Pineal Res 31:242-7. 2001
    ..Melatonin protects against the vasospastic effect of Hcy, most likely by scavenging.OH arising from Hcy autooxidation...
  84. ncbi Early and transient cytotoxic response of peritoneal cells from Fasciola hepatica-infected rats
    Pierre Sibille
    INRA Tours, BioAgresseurs, santé, Environnement, 37380 Nouzilly, France
    Vet Res 35:573-84. 2004
    ..These data suggest that a transient control of fasciolosis may take place in the peritoneum following the parasite intrusion but that the parasite efficiently scavenges the host cellular response to avoid destruction...
  85. ncbi L-arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation
    M E Gold
    Department of Pharmacology, UCLA School of Medicine 90024
    Biochem Biophys Res Commun 161:536-43. 1989
    ..Therefore, endothelium-dependent relaxants may cause arginine depletion in endothelial cells and endogenous argininosuccinic acid may modulate the biosynthesis of endothelium-derived nitric oxide from arginine...
  86. ncbi Isolation and identification of methylarginines from bovine brain
    K Kotani
    Department of Neuropsychiatry, Ehime University School of Medicine, Japan
    J Neurochem 58:1127-9. 1992
    ..1 mumol of NG,NG-dimethylarginine, and 0.5 mumol of NG,N'G-dimethylarginine. The occurrence of these free methylarginines may have an important role in regulating the signal transduction through the nitric oxide system...
  87. ncbi Tumor necrosis factor alpha inhibits contractions to sympathetic nerve stimulation by a nitric oxide-dependent mechanism
    J Xie
    Department of Medicine, Physiology, and Pharmacology, Louisiana State University Medical Center, New Orleans 70112
    Proc Soc Exp Biol Med 203:446-53. 1993
    ..TNF alpha-induced suppression of SNS and neurotransmission may contribute to the hypotension and peripheral neuropathy of sepsis...
  88. ncbi The insertion/deletion polymorphism of the angiotensin-converting enzyme gene determines coronary vascular tone and nitric oxide activity
    A Prasad
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1650, USA
    J Am Coll Cardiol 36:1579-86. 2000
    ..We investigated whether the insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene modulates vasomotor tone and endothelial function...
  89. ncbi The effect of nitric oxide synthase inhibition on histamine induced headache and arterial dilatation in migraineurs
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
    Cephalalgia 23:877-86. 2003
    ..Our results showed for the first time a craniospecificity for the vasodilating effect of histamine and for the arterial effects of NOS inhibition...
  90. ncbi Combinatory responses of proinflamamtory cytokines on nitric oxide-mediated function in mouse calvarial osteoblasts
    Young Guk Park
    Department of Orthodondritics, Kyung Hee University College of Dental Medicine, Dongdaemun Gu, Seoul 130 701, Republic of Korea
    Cell Biol Int 33:92-9. 2009
    ..The results suggest that NO may act predominantly as a modulator of cytokine-induced effects on mouse calvarial osteoblast cells and TGF-beta is a negative regulator of the NO production stimulated by IL-1beta, TNF-alpha and IFN-gamma...
  91. ncbi PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity
    Tina Branscombe Miranda
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California 90095 1569, USA
    J Biol Chem 279:22902-7. 2004
    ..These truncated proteins were enzymatically inactive, suggesting that both domains are required for functionality...
  92. ncbi Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus
    Tina Branscombe Miranda
    Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA, Los Angeles, CA 90095 1569, USA
    Biochem Biophys Res Commun 323:382-7. 2004
    ..These results suggest that the activity responsible for the formation of asymmetric dimethylated arginine residues in Sm proteins is either PRMT5 or a protein associated with it in the immunoprecipitated complex...
  93. ncbi Renal resistive index--a valid tool to assess renal endothelial function in humans?
    Ulrike Raff
    Department of Nephrology and Hypertension, University of Erlangen Nurnberg, Germany
    Nephrol Dial Transplant 25:1869-74. 2010
    ..We hypothesized that Doppler sonographic measurements of the renal resistive index in response to inhibition of nitric oxide synthase offer a new methodological approach for testing renal endothelial function...
  94. ncbi Detection of NG,NG-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody
    M Kimoto
    Department of Nutrition, School of Medicine, University of Tokushima
    J Biochem 117:237-8. 1995
    ..These results are interesting in connection with the idea that the enzyme might play a role as a regulator of nitric oxide generation in human tissues...
  95. pmc Aminoguanidine selectively inhibits inducible nitric oxide synthase
    M J Griffiths
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 110:963-8. 1993
    ..6. These results in isolated main pulmonary arteries of the rat confirm previous reports that aminoguanidine is a selective inhibitor of inducible nitric oxide synthase...
  96. ncbi Endothelium-dependent nonadrenergic, noncholinergic neural relaxation in guinea pig pulmonary artery
    S F Liu
    Department of Thoracic Medicine, National Heart and Lung Institute, London, England
    J Pharmacol Exp Ther 260:541-8. 1992
    ..Both in vivo capsaicinization and in vitro desensitization with capsaicin (1 microM) caused a significant reduction of the i-NANC relaxation in main PA, but had no significant effect in the branch PA.(ABSTRACT TRUNCATED AT 250 WORDS)..
  97. ncbi Tumor necrosis factor inhibits stimulated but not basal release of nitric oxide
    J Xie
    Department of Medicine, LSU Medical Center, New Orleans
    Am Rev Respir Dis 148:627-36. 1993
    ..This effect differs from that of L-arginine-based inhibitors of NO and represents a unique physiologic mechanism of regulation of NO in the endothelium...
  98. ncbi Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries
    A H Chester
    National Heart and Lung Institute, Harefield Hospital, Middlesex, UK
    Lancet 336:897-900. 1990
    ..These findings suggest that atherosclerotic human coronary arteries lack an important protective mechanism that normally guards against vasospasm and thrombosis...
  99. ncbi Role of L-arginine/nitric oxide pathway in the antinociceptive activities of morphine and mepyramine in mice
    N Abacioglu
    Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey
    Arzneimittelforschung 51:977-83. 2001
    ..The present results suggest that morphine and mepyramine could produce peripheral antinociception by the involvement of L-arginine/NO cascade or other related pathways of nociceptive processes induced by NO...
  100. ncbi Cardiovascular effects of acute oxygen administration in healthy adults
    W Stephen Waring
    Clinical Pharmacology Unit and Research Centre, The University of Edinburgh, Western General Hospital, Porterfield Road, Edinburgh EH4 2LH, Scotland
    J Cardiovasc Pharmacol 42:245-50. 2003
    ..05). There were no effects on vascular responses in the isolated forearm bed. These findings indicate that oxygen administration causes acute effects on cardiovascular function, which might be important in the context of acute illness...
  101. ncbi Nitric oxide-induced downregulation of leptin production by 3T3-L1 adipocytes
    Yuka Unno
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Nitric Oxide 15:125-32. 2006
    ..It is likely therefore that NO mediates downregulation of leptin caused by the IFN-gamma-LPS mixture in 3T3-L1 adipocytes, which suggests an important role for NO in adipocyte functions...

Research Grants51

  1. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
    ..This research will lead to targeted and effective medical therapy for important groups of OI patients. ..
  2. IN VIVO MECHANICAL LOADING EARLY RESPONSE GENES
    Diane Cullen; Fiscal Year: 2000
    ....
  3. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2006
    ..In addition, results of these studies may provide insights regarding possible therapeutic approaches for the treatment of nicotine-induced vascular dysfunction. ..
  4. Cerebrovascular Disease in Type 1 Diabetes
    WILLIAM MAYHAN; Fiscal Year: 2007
    ..We suggest that our results will provide novel insights regarding therapeutic approaches for the treatment/prevention of cerebrovascular dysfunction in diabetes. ..
  5. Cerebral Microcirculation During Alcohol Consumption
    WILLIAM MAYHAN; Fiscal Year: 2008
    ..These studies will provide valuable new insights and will lead to new therapeutic approaches for the treatment of cerebrovascular abnormalities observed in chronic alcoholics. [unreadable] [unreadable]..
  6. PLACENTAL FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2009
    ..Results obtained from the proposed work should enhance our knowledge and establish a direct link of placental TC activity and EC dysfunction in PE. ..
  7. Endothelial Abnormalities in Obesity/Insulin Resistance
    CHRISTOPHER DESOUZA; Fiscal Year: 2005
    ..abstract_text> ..
  8. MMP-9-Dependent Vessel Wall Remodeling is NO-Dependent
    Gilbert Upchurch; Fiscal Year: 2005
    ....
  9. Urine protein markers of disease in lupus nephritis
    James Oates; Fiscal Year: 2005
    ..Due to the power of proteomic and ANN techniques, novel mediators of disease activity and damage should be identified and thus contribute to the development of more targeted therapies for LN. ..
  10. Host Factors in Susceptibility to Chlamydial Disease
    KYLE RAMSEY; Fiscal Year: 2006
    ....
  11. Automated Chip-Based Metabolomic Analysis
    James Liao; Fiscal Year: 2006
    ..abstract_text> ..
  12. PET Approach To Measuring Human Myocardial Metabolism
    Kieren Mather; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  13. Mitochondrial respiratory uncoupling and the pathogenes*
    William Sivitz; Fiscal Year: 2006
    ..This is mediated by one or more UCP subtype. 4. Altered mitochondrial coupling and consequent changes in mitochondrial ROS formation alter endothelial cell generation of nitric oxide. ..
  14. Improving the Wegner Hall Vivarium
    BRYAN SLINKER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  15. Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
    Mias Pretorius; Fiscal Year: 2010
    ..These studies promise to provide important information regarding the effects of drugs that interrupt the RAS and generate new strategies to reduce morbidity in patients undergoing CPB. ..
  16. Nitric Oxide Interaction with Red Blood Cells
    James C Liao; Fiscal Year: 2010
    ..Specific aim 2 will focus on the functional roles of this regulation using isolated porcine pulmonary and coronary microvessels. Together, these results will suggest clinical relevance and potential interventions. ..
  17. Engineering Large scale pathways from organisms to Escherichia coli
    James Liao; Fiscal Year: 2008
    ..In particular, selected projects proposed here will be used as modules in a workshop established by FRT at Ohio State and form the basis for a course (Metabolic Engineering) at UCLA. ..
  18. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2009
    ..Mechanistic insights derived from these studies may suggest new therapeutic approaches in the treatment of acute liver injury induced by acetaminophen. ..
  19. Obesity/Insulin Resistance, Vitamin C and Endothelin-1
    CHRISTOPHER DESOUZA; Fiscal Year: 2008
    ..abstract_text> ..
  20. Biochemical and Behavioral Mechanisms of Toxicology
    JACK HINSON; Fiscal Year: 2006
    ..By training students over this continuum the investigators will add a pool of toxicologists capable of addressing our national needs. ..
  21. NOS-INDEPENDENT NO PRODUCTION IN THE NERVOUS SYSTEM
    Leonid Moroz; Fiscal Year: 2002
    ..Thus, significant gains can be made in our understanding of the synthesis of this gaseous messenger in the brain. This work will also contribute to our understanding of the neural functions in normal and pathological conditions. ..
  22. CYTOKINE DYSFUNCTION AND LUNG 5LO METABOLISM IN AIDS
    Michael Coffey; Fiscal Year: 2002
    ..This proposal will further enhance our ability to correct this defect and help boost AM, PBM, and PMN defenses against opportunistic infections in the lung in HIV disease. ..
  23. SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESS
    MICHAEL KENNEY; Fiscal Year: 2004
    ..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
  24. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2002
    ..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..
  25. RENAL INTERSTITIAL HYDROSTATIC PRESSURE IN PREGNANCY
    ALI KHRAIBI; Fiscal Year: 2003
    ....
  26. Sympathetic-Immune Interface: Central Sites & Function
    MICHAEL KENNEY; Fiscal Year: 2005
    ..Ultimately, these findings may allow for the design of intervention strategies in immune regulation fostering robust and appropriate communication between the immune and nervous systems. ..
  27. PEROXYNITRITE IN ACETAMINOPHEN INDUCED HEPATOTOXICITY
    JACK HINSON; Fiscal Year: 2002
    ..By understanding the role of peroxynitrite in acetaminophen hepatotoxicity, new treatment paradigms may be developed for hepatotoxicity, and this mechanism may be important with other toxins. ..
  28. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  29. Endothelial reactivity and nitric oxide synthetase activity in the ALMS (Aspreva
    Robert Clancy; Fiscal Year: 2009
    ..Relevance to public health: The association of markers/indices of NOS2 expression with mechanism of action of a successful drug treatment in lupus nephritis would be a major advance. ..
  30. ENDOTHELIAL BARRIER FUNCTION IN PREECLAMPSIA
    Yuping Wang; Fiscal Year: 2010
    ..The influence of CLP on placental sFlt-1 will be studied. Results obtained from the proposed work should enhance current knowledge of the role of the placenta and EC dysfunction in the pathogenesis of PE. ..
  31. Chemogenomic Analysis of E. coli Response to NO species
    James C Liao; Fiscal Year: 2010
    ..If hew TF targets are predicted, then the iteration continues. Otherwise, the predicted networks are verified using genetic and biochemical experiments. ..
  32. AGING, EXERCISE AND ENDOTHELIAL FUNCTION
    CHRISTOPHER DESOUZA; Fiscal Year: 2002
    ..He and the host department will provide Dr. DeSouza all of the necessary resources to successfully complete his training. (End of Abstract) ..
  33. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  34. Role of nitric oxide and eicosanoids in lupus nepthritis
    James Oates; Fiscal Year: 2005
    ..In either event, future studies would address the use of selective COX-2 or TXA2 synthase inhibitors/receptor blockers, antioxidants, and/or PGI2/PGE2 agonists in conduction with iNOS inhibitors as therapies for LN. ..
  35. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    ..After 7 days, the lungs will be analyzed to determine if connective tissue content and lung fluid have increased. These studies will test a previously unknown mechanism for the pulmonary edema associated with heart failure. ..
  36. Microvascular Permeability and Sex
    VIRGINIA HUXLEY; Fiscal Year: 2008
    ....
  37. HIV-1 Infection and Endothelial t-PA Release
    CHRISTOPHER DESOUZA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  38. Cardiac myofibroblasts in autoimmune-associated CHB
    Robert Clancy; Fiscal Year: 2002
    ....
  39. Inflammatory response to sleep apnea in obese subjects
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2010
    ..We propose that this study design will provide the best way to separate the independent effects of obesity and OSA on cardiovascular risk. ..
  40. ROLE OF HEMODYNAMICS IN IN VIVO INSULIN RESISTANCE
    Kieren Mather; Fiscal Year: 2003
    ..If the data confirm our hypothesis, treatment of IR patients with ET1 antagonists may be a rational and beneficial approach to reducing the dreaded cardiovascular outcomes associated with IR and type 2 diabetes. ..
  41. Nephrology Training Grant
    Scott Thomson; Fiscal Year: 2008
    ..An interactive research environment and shared seminar programs between UCSD, Salk Institute, and numerous other research institutes in La Jolla further enhances the training program. ..
  42. EFFECTS OF NITRIC OXIDE ON FETOPLACENTAL ANGIOGENESIS
    Jing Zheng; Fiscal Year: 2008
    ..An additional Specific Aim IV will use the HPME cell line to confirm the key observations made from OFPAE cells. These studies will glean important information on the mechanisms regulating placental angiogenesis. ..
  43. Aging, Exercise and Endothelin-1 Vasoconstrictor Tone
    CHRISTOPHER DESOUZA; Fiscal Year: 2007
    ....
  44. Skin Blood Flow in Diabetes: Local and Reflex Control
    Nisha Charkoudian; Fiscal Year: 2007
    ....
  45. Study of Intrinsic Bladder Activity by Optical Imaging
    Anthony Kanai; Fiscal Year: 2007
    ..To study the neural-chemical control of spontaneous detrusor activity; and III.) To determine the origin of detrusor overactivity in partially obstructed bladders. ..
  46. TOSCA-2 An Angiographic Substudy of the Occluded Arter*
    Vladimir Dzavik; Fiscal Year: 2004
    ..The Data Coordinating Center (DCC) is the Maryland Medical Research Institute, the DCC of OAT. The An2iogiraphic Core Laboratory is at the University of British Columbia. ..
  47. Hsp90, NOS3 and Cardioprotection
    Yang Shi; Fiscal Year: 2009
    ..abstract_text> ..
  48. Obesity/Insulin Resistance and Endothelial t-PA Release
    CHRISTOPHER DESOUZA; Fiscal Year: 2003
    ..abstract_text> ..