ng nitroarginine methyl ester

Summary

Summary: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.

Top Publications

  1. ncbi Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines
    Ming Hao Yin
    Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Medicinal Resources Research Institute MeRRI, Wonkwang University, Iksan, Jeonbuk 570 749, Republic of Korea
    J Ethnopharmacol 99:113-7. 2005
  2. ncbi Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin
    K Kimura
    Division of Cardiology, Wakayama Medical College, Wakayama, Japan
    Biochem Biophys Res Commun 273:745-9. 2000
  3. ncbi Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide
    G Fruhbeck
    Metabolic Research Laboratory, University of Navarra, 31008, Pamplona, Spain
    Cell Signal 13:827-33. 2001
  4. ncbi Nitric oxide decreases subventricular zone stem cell proliferation by inhibition of epidermal growth factor receptor and phosphoinositide-3-kinase/Akt pathway
    Ana Torroglosa
    Area de Fisiologia, Facultad de Medicina, Universidad de Cadiz, Plaza Falla 9, 11003 Cadiz, Spain
    Stem Cells 25:88-97. 2007
  5. ncbi Nitric oxide induces [Ca2+]i oscillations in pituitary GH3 cells: involvement of IDR and ERG K+ currents
    Agnese Secondo
    Division of Pharmacology, Dept of Neuroscience, School of Medicine, Federico II Univ of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
    Am J Physiol Cell Physiol 290:C233-43. 2006
  6. ncbi Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy
    Chandrashekhar S Patil
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Pharmacology 72:190-5. 2004
  7. pmc Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila
    Edan Foley
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143, USA
    Genes Dev 17:115-25. 2003
  8. ncbi Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries
    Wendy W Batenburg
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    Circulation 109:2296-301. 2004
  9. ncbi Chronic blockade of NO synthase paradoxically increases islet NO production and modulates islet hormone release
    R Henningsson
    Institute of Physiological Sciences, University of Lund, Lund, Sweden
    Am J Physiol Endocrinol Metab 279:E95-E107. 2000
  10. ncbi Effects of Cudrania tricuspidata water extract on blood pressure and renal functions in NO-dependent hypertension
    Dae Gill Kang
    Department of Herbal Resources, Professional Graduate School of Oriental Medicine, and Medicinal Resources Research Centre, Wonkwang University, Iksan, Jeonbuk, Republic of Korea
    Life Sci 70:2599-609. 2002

Detail Information

Publications197 found, 100 shown here

  1. ncbi Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines
    Ming Hao Yin
    Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Medicinal Resources Research Institute MeRRI, Wonkwang University, Iksan, Jeonbuk 570 749, Republic of Korea
    J Ethnopharmacol 99:113-7. 2005
    ..These results will be useful to further analyze those medicinal plants that contain the vasorelaxant activity in order to identify the active principles...
  2. ncbi Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin
    K Kimura
    Division of Cardiology, Wakayama Medical College, Wakayama, Japan
    Biochem Biophys Res Commun 273:745-9. 2000
    ..These results suggest that arterial relaxation by leptin is mediated by nitric oxide released from endothelium, and Cl(-) plays an important role in leptin-induced nitric oxide release...
  3. ncbi Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide
    G Fruhbeck
    Metabolic Research Laboratory, University of Navarra, 31008, Pamplona, Spain
    Cell Signal 13:827-33. 2001
    ..These findings suggest that NO is a potential regulator of leptin-induced lipolysis...
  4. ncbi Nitric oxide decreases subventricular zone stem cell proliferation by inhibition of epidermal growth factor receptor and phosphoinositide-3-kinase/Akt pathway
    Ana Torroglosa
    Area de Fisiologia, Facultad de Medicina, Universidad de Cadiz, Plaza Falla 9, 11003 Cadiz, Spain
    Stem Cells 25:88-97. 2007
    ....
  5. ncbi Nitric oxide induces [Ca2+]i oscillations in pituitary GH3 cells: involvement of IDR and ERG K+ currents
    Agnese Secondo
    Division of Pharmacology, Dept of Neuroscience, School of Medicine, Federico II Univ of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
    Am J Physiol Cell Physiol 290:C233-43. 2006
    ..The present study suggests that in GH3 cells, endogenous NO plays a permissive role for the occurrence of spontaneous [Ca2+]i oscillations through an inhibitory effect on IDR and on IERG...
  6. ncbi Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy
    Chandrashekhar S Patil
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Pharmacology 72:190-5. 2004
    ..The results in the present study demonstrate that the decreased nNOS-cGMP system may play a crucial role in the pathogenesis of diabetic neuropathy...
  7. pmc Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila
    Edan Foley
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143, USA
    Genes Dev 17:115-25. 2003
    ..We propose that NO mediates an early step of the signal transduction pathway, inducing the innate immune response upon natural infection with gram-negative bacteria...
  8. ncbi Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries
    Wendy W Batenburg
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    Circulation 109:2296-301. 2004
    ..In contrast, AT2 receptor-mediated vasodilation could not be observed in large human coronary arteries. We studied Ang II-induced vasodilation of human coronary microarteries (HCMAs)...
  9. ncbi Chronic blockade of NO synthase paradoxically increases islet NO production and modulates islet hormone release
    R Henningsson
    Institute of Physiological Sciences, University of Lund, Lund, Sweden
    Am J Physiol Endocrinol Metab 279:E95-E107. 2000
    ....
  10. ncbi Effects of Cudrania tricuspidata water extract on blood pressure and renal functions in NO-dependent hypertension
    Dae Gill Kang
    Department of Herbal Resources, Professional Graduate School of Oriental Medicine, and Medicinal Resources Research Centre, Wonkwang University, Iksan, Jeonbuk, Republic of Korea
    Life Sci 70:2599-609. 2002
    ..Taken together, these results suggest that C tricuspidata water extract prevents the increase of SBP in the L-NAME-induced hypertension that may have been caused by enhanced generation of vascular NO/cGMP...
  11. ncbi Effects of L-NAME and inhaled nitric oxide on ventilator-induced lung injury in isolated, perfused rabbit lungs
    Alain F Broccard
    University of Minnesota, Pulmonary and Critical Care Division, Regions Hospital, St Paul, MN, USA
    Crit Care Med 32:1872-8. 2004
    ..To determine whether nitric oxide (NO) might modulate ventilator-induced lung injury...
  12. ncbi Role of nitric oxide on in vitro human eosinophil migration
    S M Thomazzi
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, P.O. Box 6111, 13081-970, SP, Campinas, Brazil
    Biochem Pharmacol 62:1417-21. 2001
    ..0 mM dibutyryl cyclic GMP. In conclusion, this study demonstrates that human eosinophils present a nitric oxide-cyclic GMP pathway that is involved in the in vitro locomotion of this cell type...
  13. pmc Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues
    G Panagiotidis
    Department of Pharmacology, University of Lund, Sweden
    Br J Pharmacol 114:289-96. 1995
    ..8. Taken together with previous data the present results suggest that islet production of low physiological levels of free radicals such as NO and H202 may serve as important modulators of insulin secretory processes...
  14. ncbi Age related differences in stress-induced neurobehavioral responses in rats: modulation by antioxidants and nitrergic agents
    Ayanabha Chakraborti
    Department of Pharmacology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India
    Behav Brain Res 194:86-91. 2008
    ....
  15. ncbi Role of nitric oxide synthase isoforms in glucose-stimulated insulin release
    Ragnar Henningsson
    Institute of Physiological Sciences, Department of Pharmacology, University of Lund, S 221 84 Lund, Sweden
    Am J Physiol Cell Physiol 283:C296-304. 2002
    ..The results also suggest that hyperglycemia-evoked islet NOS activity might be one of multiple factors involved in the impairment of glucose-stimulated insulin release in type II diabetes mellitus...
  16. ncbi Arginase activity is inhibited by L-NAME, both in vitro and in vivo
    Daniele Reisser
    Faculty of Medicine and Pharmacy, Cancer Immunotherapy Research Laboratory, Ecole Pratique des Hautes Etudes, INSERM U517, 7 bd Jeanne d Arc, 21079 Dijon, France
    J Enzyme Inhib Med Chem 17:267-70. 2002
    ..The effect of L-NAME on arginase requires consideration when it is used in vivo in animal models with the aim of inhibiting endothelial NO-synthase, another enzyme using arginine as substrate...
  17. ncbi Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis
    Yasushi Nakamura
    Department of Pathology, Wakayama Medical University, Wakayama City, Wakayama, Japan
    Clin Cancer Res 12:1201-7. 2006
    ..Nitric oxide (NO) may also increase metastatic ability in human cancers...
  18. ncbi Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products
    Biao Xu
    Center for Cardiovascular Biology and Medicine, King s College London, London SE1 1UL, UK
    FASEB J 17:1289-91. 2003
    ..Furthermore, these effects all occurred at CML concentrations similar to those found in the plasma of diabetic patients. These results suggest an important role of AGE in the pathogenesis of diabetic vasculopathy...
  19. ncbi Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase
    F Tao
    Department of Anesthesiology and Critical Care Medicine, Blalock 1415, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287 4965, USA
    Neuroscience 120:847-54. 2003
    ..This suggests that iNOS may be sufficient, but not essential, for the late phase of the carrageenan-induced thermal hyperalgesia...
  20. ncbi Evaluation of islet heme oxygenase-CO and nitric oxide synthase-NO pathways during acute endotoxemia
    R Henningsson
    Department of Pharmacology, Institute of Physiological Sciences, University of Lund, S 223 62 Lund, Sweden
    Am J Physiol Cell Physiol 280:C1242-54. 2001
    ....
  21. ncbi Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes
    M G Petroff
    Laboratory of Cardiovascular Science, Gerontology Research Center, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224-6825, USA
    Nat Cell Biol 3:867-73. 2001
    ..We propose that myocyte NO produced by activation of the PI(3)K-Akt-endothelial NOS axis acts as a second messenger of stretch by enhancing RyRC activity, contributing to myocardial contractile activation...
  22. ncbi Role of endogenous nitric oxide in endotoxin-induced alteration of hypoxic pulmonary vasoconstriction in mice
    Fabian Spöhr
    Department of Anaesthesiology, Ruprecht Karls University, Heidelberg, Germany
    Am J Physiol Heart Circ Physiol 289:H823-31. 2005
    ..Furthermore, impaired HPV during endotoxemia may be at least in part mediated by mechanisms other than simply pulmonary vasodilation by NOS2-derived NO overproduction...
  23. ncbi Changes in the dimeric state of neuronal nitric oxide synthase affect the kinetics of secretagogue-induced insulin response
    Anne Dominique Lajoix
    CNRS UMR 5160, Institut de Biologie, 4 Boulevard Henri IV, 34960 Montpellier Cedex 2, France
    Diabetes 53:1467-74. 2004
    ..We conclude that intracellular factors able to induce abnormalities in the nNOS monomer/dimer equilibrium could lead to pancreatic beta-cell dysfunction...
  24. ncbi Glucose stimulates the expression and activities of nitric oxide synthases in incubated rat islets: an effect counteracted by GLP-1 through the cyclic AMP/PKA pathway
    Javier Jimenez-Feltstrom
    Department of Pharmacology, Institute of Physiological Sciences, University of Lund, 221 84 Lund, Sweden
    Cell Tissue Res 319:221-30. 2005
    ..The inhibition of iNOS expression by the GLP-1/cyclic AMP/PKA pathway might possibly be of therapeutic potential in NO-mediated beta-cell dysfunction and destruction...
  25. ncbi Contributions of nitric oxide synthase isozymes to exhaled nitric oxide and hypoxic pulmonary vasoconstriction in rabbit lungs
    David J Vaughan
    Department of Pediatrics, Children s Hospital and Regional Medical Center, Seattle 98105, USA
    Am J Physiol Lung Cell Mol Physiol 284:L834-43. 2003
    ..Our findings show virtually all exhaled NO in the rabbit lung is produced by eNOS, which is present throughout the airways, alveoli, and vessels. Both vascular and epithelial-derived NO modulate HPV...
  26. ncbi Vascular reactivity in intrapulmonary arteries of chicken embryos during transition to ex ovo life
    Eduardo Villamor
    Department of Pediatrics, University Hospital Maastricht, Research Institute Growth and Development, University of Maastricht, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 282:R917-27. 2002
    ..Chicken embryo pulmonary arteries show a marked endothelium-dependent relaxation that is unaffected by transition to ex ovo life. Endothelium-derived NO seems to be the main mediator responsible for this relaxation...
  27. ncbi Nitric oxide in papillary thyroid carcinoma: induction of vascular endothelial growth factor D and correlation with lymph node metastasis
    Yasushi Nakamura
    Department of Pathology, Wakayama Medical University, 811 1 Kimiidera, 641 8509 Wakayama City, Japan
    J Clin Endocrinol Metab 91:1582-5. 2006
    ..Although PTC metastasizes to regional lymph nodes at a high frequency, the regulation of VEGF-D expression is largely unknown...
  28. ncbi Nitric oxide participates in cataract development in selenite-treated rats
    Y Ito
    School of Pharmaceutical Sciences, Kinki University, Osaka, Japan
    Curr Eye Res 22:215-20. 2001
    ..The results also suggest that nitric oxide had an important role in the development of selenite-induced cataracts...
  29. ncbi Spontaneous nitric oxide in hepatocyte monolayers and inhibition of compound-induced apoptosis
    C Dilworth
    Aventis CropScience, 355 rue Dostoievski, BP-153, 06903, Sophia Antipolis, France
    Toxicol In Vitro 15:623-30. 2001
    ..These findings indicate that the increased levels of NO associated with the culture of hepatocytes have an inhibitory effect on compound-induced apoptosis in the cells...
  30. ncbi Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain
    Ya Chun Chu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Pain 119:113-23. 2005
    ..Our findings suggest that spinal cord nNOS might play a critical role in central mechanisms of the development and/or maintenance of chronic inflammatory pain...
  31. pmc Nitric oxide regulates human eosinophil adhesion mechanisms in vitro by changing integrin expression and activity on the eosinophil cell surface
    N Conran
    Department of Pharmacology, FCM, UNICAMP, Campinas, Brazil
    Br J Pharmacol 134:632-8. 2001
    ..This inhibition is accompanied by a decrease in the expression and function of the eosinophil's adhesion molecules, in particular, the expression of the Mac-1 integrin and the function of the VLA-4 integrin...
  32. ncbi Chronic moderate hypoxia and protein malnutrition both induce growth retardation, but have distinct effects on arterial endothelium-dependent reactivity in the chicken embryo
    Karin Ruijtenbeek
    Department of Pediatrics, Research Institute Growth and Development GROW, University Hospital Maastricht, The Netherlands
    Pediatr Res 53:573-9. 2003
    ..Intrauterine exposure to chronic hypoxia induces changes in arterial endothelial properties that may play a role in the development of cardiovascular disease in adult life...
  33. ncbi Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition
    G J Ji
    Institute of Neurophysiology, University of Cologne, Cologne, Germany
    FASEB J 13:313-24. 1999
    ..These findings indicate a fundamental role for NO as a signaling molecule during early embryonic development and demonstrate a switch in the signaling cascades governing ICa regulation...
  34. ncbi Manganese enhances peroxynitrite and leukotriene E4 formation in bovine aortic endothelial cells exposed to arsenic
    Melisa Bunderson
    Department of Biomedical and Pharmaceutical Sciences and Center for Environmental Health Sciences, The University of Montana, Missoula, 59812, USA
    Cardiovasc Toxicol 6:15-23. 2006
    ..Overall, these data suggest that manganese may exacerbate the toxic effects of arsenic on the vascular system...
  35. ncbi Nitric oxide has a role in regulating VLA-4-integrin expression on the human neutrophil cell surface
    Nicola Conran
    Department of Pharmacology, FCM, UNICAMP, Campinas, Brazil
    Biochem Pharmacol 66:43-50. 2003
    ....
  36. ncbi Effect of N(G)-nitro-L-arginine methyl ester on intestinal permeability following intestinal ischemia-reperfusion injury in a rat model
    C C Luo
    Department of Pediatric Surgery and Pediatrics, Chang Gung Children s Hospital and College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Biol Neonate 80:60-3. 2001
    ..These results suggest that endogenous NO may play a role in the protecting intestinal integrity after IRI...
  37. ncbi Salt-sensitive hypertension in conscious rats induced by chronic nitric oxide blockade
    Kazushige Nakanishi
    Second Department of Internal Medicine, Toho University, School of Medicine, Tokyo, Japan
    Am J Hypertens 15:150-6. 2002
    ..Nitric oxide plays an important role in the development of salt-sensitive hypertension with the change of MBF...
  38. ncbi The involvement of nitric oxide in the analgesic effects of ketamine
    Fusun Bulutcu
    Department of Anesthesiology, Kadir Has University, Florance Nightingale Hospital, Istanbul, Turkey
    Life Sci 71:841-53. 2002
    ..These data suggest that the activation of the NO-cGMP pathway probably at the supraspinal level, but not spinal level, contributes to the antinociceptive effects of ketamine...
  39. ncbi Aging decreases vasoconstrictor responses of coronary resistance arterioles through endothelium-dependent mechanisms
    Robert D Shipley
    Department of Health and Kinesiology, Texas A and M University, College Station, Texas 77843, USA
    Cardiovasc Res 66:374-83. 2005
    ..This study tested the hypothesis that aging increases the vasoconstrictor responsiveness of coronary arterioles isolated from myocardium of young (4 months) and old (24 months) Fischer 344 rats...
  40. ncbi Involvement of cyclic guanosine 3',5'-monophosphate in nitric oxide-induced glucagon secretion from pancreatic alpha cells
    T Mori
    First Division, Department of Medicine, Shimane Medical University, Izumo, Japan
    Metabolism 50:703-7. 2001
    ..These findings also provide further evidence that l-arginine might play a stimulating role in regulating glucagon secretion, at least partly, through generation of NO in the islets...
  41. ncbi Resting tension effect on airway smooth muscle: the involvement of epithelium
    Apostolia A Hatziefthimiou
    Department of Physiology, Medical School, University of Thessaly, Papakiriazi 22, 41222 Larissa, Greece
    Respir Physiol Neurobiol 145:201-8. 2005
    ..5 g RT partly via NO release. At 0.5 g RT, the endogenous production of prostanoids by sources other than epithelium modulates the contractility of TSM to acetylcholine...
  42. ncbi Nitric oxide and hydroperoxide affect islet hormone release and Ca(2+) efflux
    B Akesson
    Department of Pharmacology, University of Lund, Sweden
    Endocrine 11:99-107. 1999
    ..These effects are largely independent of depolarization events. By contrast, both NO and hydroperoxide can potentiate cAMP-stimulated hormone release presumably at a distal site in the stimulus-secretion coupling...
  43. ncbi Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells
    J Dulak
    Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland
    Arterioscler Thromb Vasc Biol 20:659-66. 2000
    ..The results indicate that endogenous NO enhances VEGF synthesis. The positive interaction between endogenous NO and VEGF may have implications for endothelial regeneration after balloon angioplasty and for angiogenesis...
  44. pmc Arrest of B16 melanoma cells in the mouse pulmonary microcirculation induces endothelial nitric oxide synthase-dependent nitric oxide release that is cytotoxic to the tumor cells
    Hongming Qiu
    Department of Pathology, Faculty of Medicine, and the Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Pathol 162:403-12. 2003
    ....
  45. ncbi Pivotal role of nitric oxide in the control of blood pressure after leptin administration
    G Fruhbeck
    Department of Endocrinology, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Spain
    Diabetes 48:903-8. 1999
    ..The leptin-induced hypotension observed in the setting of ganglionic blockade was blocked by L-NAME. These findings raise the possibility that the leptin-induced release of NO may contribute to the homeostasis of BP...
  46. ncbi Inducible nitric oxide synthase inhibitors suppress airway inflammation in mice through down-regulation of chemokine expression
    A Trifilieff
    Novartis Horsham Research Centre, Horsham, United Kingdom Immuno Hematology Group, hôpital La Pitié Salpêtrière, Paris, France
    J Immunol 165:1526-33. 2000
    ..NO appears to increase lung chemokine expression and, thereby, to facilitate influx of inflammatory cells into the airways...
  47. ncbi Nitric oxide decreases lung injury after intestinal ischemia
    L S Terada
    University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Appl Physiol (1985) 81:2456-60. 1996
    ..We conclude that endogenous lung NO limits secondary lung injury after intestinal I/R by decreasing pulmonary neutrophil retention...
  48. ncbi Role of endogenous nitric oxide in liver-specific functions and survival of cultured rat hepatocytes
    M T Donato
    , Centro de Investigation, Hospital Universitario La Fe, Valencia, Spain
    Xenobiotica 31:249-64. 2001
    ..4. In conclusion, inhibition of early endogenous nitric oxide formation is an efficient procedure for obtaining hepatocyte cultures with stable expression of differentiated functions, high cell survival and few signs of cell senescence...
  49. ncbi Role of nitric oxide in histamine release from human basophils and rat peritoneal mast cells
    K H Peh
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Eur J Pharmacol 425:229-38. 2001
    ..The effects of L-arginine, D-arginine and sodium nitroprusside may involve mechanisms unrelated to NO...
  50. pmc Detrimental effects of N(omega) nitro-L-arginine methyl ester (L-NAME)in experimental Escherichia coli sepsis in the newborn piglet
    Sung Shin Kim
    Department of Pediatrics, Bucheon Hospital, Soonchunhyang University, College of Medicine, Bucheon, Korea
    J Korean Med Sci 18:637-40. 2003
    ..These findings suggest that nonselective inhibition of nitric oxide synthase with L-NAME is detrimental during the early phase of experimental neonatal sepsis...
  51. ncbi Stimulation by nitric oxide of gastric acid secretion in bullfrog fundic mucosa in vitro
    S Kawauchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Japan
    J Physiol Pharmacol 52:93-105. 2001
    ..In addition, it was speculated that the histamine releasing action of NO may be due to peroxynitrite produced by NO and superoxide radicals...
  52. ncbi Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity
    Christos Polytarchou
    Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, GR 26504, Greece
    Eur J Pharmacol 510:31-8. 2005
    ..In conclusion, superoxide and hydrogen peroxide seem to play a significant role in promoting endothelial cell proliferation and migration, possibly through regulation of eNOS activity...
  53. ncbi Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis
    F Facchinetti
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuroscience 90:1483-92. 1999
    ..Together, these results do not support a significant role for neuronal-derived nitric oxide in the pathogenesis of familial amyotrophic lateral sclerosis transgenic mice...
  54. ncbi Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: contributions of NOS isoforms to blood pressure and heart rate control
    G Kojda
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Cardiovasc Res 42:206-13. 1999
    ..It is unclear if and to what extent NOS isoforms other than eNOS contribute to this effect and how loss of one copy of the eNOS gene might impact on vascular reactivity or eNOS protein expression...
  55. ncbi Signal transduction in islet hormone release: interaction of nitric oxide with basal and nutrient-induced hormone responses
    A Salehi
    Department of Pharmacology, University of Lund, Sweden
    Cell Signal 10:645-51. 1998
    ..The observed NO effects on islet hormone release can proceed independently of membrane-depolarisation events...
  56. ncbi Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the wobbler mouse
    K Ikeda
    The Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan
    J Neurol Sci 160:9-15. 1998
    ..To a lesser degree, L-NAME-treated mice displayed slowed progression of disease. The present studies indicate that neuronal NOS inhibitor may be a candidate for promising therapy in lower motoneuron disease or motor neuropathy...
  57. ncbi Time course of nitric oxide production and epithelial dysfunction during ischemia/reperfusion of the feline small intestine
    S Kanwar
    Department of Medical Physiology, University of Calgary, Alberta, Canada
    Circ Shock 42:135-40. 1994
    ..In conclusion, a reduction in nitric oxide production was observed with time of reperfusion, possibly due to reduced nitric oxide synthase levels...
  58. ncbi The pressor effect of NO synthase inhibition correlates to pre-existing systolic BP in the rat
    Hamzeh H Elayan
    Faculty of Medicine, Jordan University
    Auton Neurosci 95:32-6. 2002
    ..36, P < 0.0003). The results suggest that shear stress generated by blood flow during the systole releases NO, and lowers BP. The pressor effect of NO synthase inhibition is closely related to pre-existing systolic BP...
  59. ncbi Role of Nitric oxide in the renal and systemic vasodilatory responses to platelet-activating factor in the rat, in vivo
    Rajash K Handa
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Kidney Blood Press Res 26:165-75. 2003
    ..Because nitric oxide (NO) and PAF have many similar cardiovascular actions, we examined whether endogenous NO contributes to the renal and systemic actions of PAF...
  60. ncbi Synergistic interaction of diazepam with 3',5'-cyclic adenosine monophosphate-elevating agents on rat aortic rings
    A Galindo
    , Facultad de Medicina, Universidad de Murcia, Espinardo-Murcia, Spain
    Eur J Pharmacol 428:269-75. 2001
    ..Our results demonstrate a functional and biochemical synergistic interaction of diazepam with cyclic AMP-elevating agents on rat aortic rings...
  61. ncbi Time-dependent reduction of acetylcholine-induced relaxation in aortic rings of cholestatic rats
    H Rastegar
    Department of Pharmacology, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Pharmacol Res 44:519-25. 2001
    ....
  62. pmc Nitric oxide-dependent beta2-adrenergic dilatation of rat aorta is mediated through activation of both protein kinase A and Akt
    Albert Ferro
    Department of Clinical Pharmacology, Division of Cardiovascular Science, GKT School of Medicine, King s College London Guy s Campus, 2 36B New Hunts House, London Bridge, London SE1 1UL
    Br J Pharmacol 143:397-403. 2004
    ..The latter is predominantly PKA-mediated, whereas the former occurs through both PKA and PI3K/Akt activation...
  63. ncbi Isoproterenol amplifies 17 beta-estradiol-mediated vasorelaxation: role of endothelium/nitric oxide and cyclic AMP
    Hoi Yun Chan
    Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Cardiovasc Res 53:627-33. 2002
    ..The present study was designed to investigate the synergistic interaction between isoproterenol and 17 beta-estradiol, and the role of endothelium and cyclic AMP-dependent pathway in this interaction...
  64. ncbi Role of nitric oxide during coronary endothelial dysfunction after myocardial infarction
    An Berges
    Laboratory of Cardiology, University of Antwerp, Wilrijkstraat 10, Edegem 2650, Belgium
    Eur J Pharmacol 516:60-70. 2005
    ..Although the NO-mediated response is increased after ischaemia, its final action is restricted due to the presence of superoxide...
  65. ncbi alpha2-Adrenoceptor subsensitivity in mesenteric vascular bed of cholestatic rats: the role of nitric oxide and endogenous opioids
    Amir Ali Borhani
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Eur J Pharmacol 514:183-9. 2005
    ....
  66. ncbi Role of endothelium-dependent mechanism in formation of systemic hemodynamic responses to hypervolemia
    L I Osadchii
    Laboratory of Blood Circulation Physiology, I P Pavlov Institute of Physiology, Russian Academy of Sciences, St Petersburg, Russia
    Bull Exp Biol Med 136:432-4. 2003
    ..It was concluded that vasodilatation induced by increased systemic blood flow (cardiac output) modulates pressor responses under conditions of increased blood volume...
  67. ncbi Involvement of nitric oxide in both central and peripheral haemodynamic effect of D/L-nebivolol and its enantiomers in rats
    Giuseppe Sacco
    Menarini Ricerche SpA, Pharmacology, Via Tito Speri 10, 00040 Pomezia, Rome, Italy
    Eur J Pharmacol 511:167-74. 2005
    ....
  68. ncbi Administration of N(omega)-L-arginine methyl ester (L-NAME) impairs endothelium-dependent relaxation in gravid but not nongravid rats
    Jose Martinez-Orgado
    Area de Pediatría y Neonatología, Fundacion Hospital Alcorcon, Madrid, Spain
    J Soc Gynecol Investig 10:74-81. 2003
    ....
  69. ncbi Inhibition by ebselen on nitric oxide mediated relaxations in the rat anococcygeus muscle
    Yan Che
    Division of Biosciences, School of Medical Sciences, RMIT University, GPO Box 71, Bundoora, Victoria 3083, Australia
    Eur J Pharmacol 462:161-8. 2003
    ..Ebselen does not appear to directly interact with NO, but it may inhibit NO release from nitrosothiols by a thiol- and/or copper-dependent mechanism...
  70. ncbi Cyclooxygenase pathway is involved in the vascular reactivity and inhibition of the Na+, K+-ATPase activity in the tail artery from L-NAME-treated rats
    Leonardo dos Santos
    Departamento de Ciencias Fisiologicas, Centro Biomedico, Universidade Federal do Espirito Santo, Brazil
    Life Sci 74:613-27. 2003
    ....
  71. ncbi The effect of walking on regional blood flow and acetylcholine in the hippocampus in conscious rats
    Kaori Nakajima
    Graduate School of Humanities and Sciences, Ochanomizu University, Bunkyo, Tokyo 112 8610, Japan
    Auton Neurosci 103:83-92. 2003
    ....
  72. ncbi Relative roles of endothelial relaxing factors in cyclosporine-induced impairment of cholinergic and beta-adrenergic renal vasodilations
    Mahmoud M El-Mas
    Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
    Eur J Pharmacol 487:149-58. 2004
    ..It is concluded that the identity and relative contributions of endothelial factors to renal vasodilatory responses as well as to the inhibition of these responses by cyclosporine largely depend on the vasodilator stimulus...
  73. ncbi Vasoactive systems in L-NAME hypertension: the role of inducible nitric oxide synthase
    Olga Pechanova
    Center for Experimental Cardiovascular Research, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Hypertens 22:167-73. 2004
    ..Furthermore, we studied the extent of nitric oxide (NO) synthesis inhibition and the participation of remaining NO in the counterbalance of pressor systems, with a special reference to inducible nitric oxide synthase (iNOS)...
  74. ncbi Effect of L-arginine on Na+,K+-ATPase activity in rat aorta endothelium
    O V Akopova
    Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, 01024, Ukraine
    Biochemistry (Mosc) 67:1058-61. 2002
    ....
  75. ncbi Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta
    Petr Vetrovsky
    Pharmacology and Physico Chemistry, Centre National de la Recherche Scientifique Unité Mixte Recherche 7034 and University Louis Pasteur, Strasbourg, France
    J Pharmacol Exp Ther 303:823-30. 2002
    ..On one hand, L-NOHA and amidoximes may be useful tools for characterizing this pathway in blood vessels and, on the other, may offer a novel approach for treating vascular diseases with impaired endothelial NO activity...
  76. ncbi Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors
    Luciana V Rossoni
    Department of Pharmacology and Therapeutics, Faculty of Medicine, Autonomous University of Madrid, C Arzobispo Morcillo 4, 28029 Madrid, Spain
    Am J Physiol Heart Circ Physiol 283:H2110-8. 2002
    ....
  77. ncbi Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes
    Milad S Bitar
    Department of Pharmacology, Kuwait University, School of Medicine, Kuwait
    Eur J Pharmacol 511:53-64. 2005
    ..This phenomenon could play a potentially important role in the pathogenesis of diabetic endothelial dysfunction...
  78. ncbi Captopril reverses the reduced vasodilator response to bradykinin in hypertensive pregnant rats
    A C Resende
    Department of Pharmacology, IBRAG CB State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Clin Exp Pharmacol Physiol 31:756-61. 2004
    ..Pregnancy does not modify the relative contribution of the EDHF and NO to the vasodilator effect of BK...
  79. ncbi Relaxatory effect of magnesium on mesenteric vascular beds differs from normal and streptozotocin induced diabetic rats
    Nepton Soltani
    Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Engelab ave Tehran, Iran
    Eur J Pharmacol 508:177-81. 2005
    ....
  80. pmc Involvement of EDHF in the hypotension and increased gastric mucosal blood flow caused by PAR-2 activation in rats
    Atsufumi Kawabata
    School of Pharmaceutical Sciences, Kinki University, Higashi Osaka 577 8502, Japan
    Br J Pharmacol 140:247-54. 2003
    ..6. Our data suggest involvement of apamin/charybdotoxin-sensitive K+ channels in the PAR-2-triggered hypotension and increased GMBF, predicting a role of EDHF-like factors...
  81. ncbi In vivo regulation of endothelium-dependent vasodilation in the rat renal circulation and the effect of streptozotocin-induced diabetes
    Amanda J Edgley
    Department of Physiology, Monash University, Clayton, Australia
    Am J Physiol Regul Integr Comp Physiol 295:R829-39. 2008
    ..After prior inhibition of NO synthase, EDHF mediates transient renal vasodilation in vivo. Renal endothelium-dependent vasodilation is diminished in diabetes due to impaired NO function...
  82. ncbi Attenuation of nitric oxide- and prostaglandin-independent vasodilation of retinal arterioles induced by acetylcholine in streptozotocin-treated rats
    Taisuke Nakazawa
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Vascul Pharmacol 46:153-9. 2007
    ..These results suggest that diabetes impairs EDHF-mediated vasodilation of retinal arterioles induced by acetylcholine. The impaired EDHF-mediated vasodilation may contribute to alteration of retinal hemodynamics in diabetes...
  83. ncbi Protective effect of prior physical conditioning on relaxing response of corpus cavernosum from rats made hypertensive by nitric oxide inhibition
    M A Claudino
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas, Sao Paulo, Brazil
    Int J Impot Res 19:189-95. 2007
    ..In conclusion, our study shows a beneficial effect of prior physical conditioning on the impaired CC relaxing responses in rats made hypertensive by chronic NO blockade...
  84. ncbi Rho-kinase contributes to hypoxia/reoxygenation-induced cerebral endothelial dysfunction
    Hui Xie
    Department of Neonatology, Children s Research Institute, Children s National Medical Center, The George Washington University, Washington, DC 20010, USA
    J Cardiovasc Pharmacol 48:814-9. 2006
    ..Pretreatment with either Y27632 or the stable NO donor profoundly prevented H/R-mediated cerebral endothelial dysfunction...
  85. ncbi Tumor necrosis factor-alpha increases cerebral blood flow and ultrastructural capillary damage through the release of nitric oxide in the rat brain
    Eszter Farkas
    Department of Anatomy, School of Medicine, University of Szeged, Szeged, Hungary
    Microvasc Res 72:113-9. 2006
    ..Our data additionally demonstrate that the breakdown of the BBB by circulating TNFalpha may involve the astrocytic endfeet...
  86. ncbi Alpha1D-adrenoceptor-induced relaxation on rat carotid artery is impaired during the endothelial dysfunction evoked in the early stages of hyperhomocysteinemia
    Claudia Roberta de Andrade
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Eur J Pharmacol 543:83-91. 2006
    ....
  87. ncbi Vasorelaxing effects of propranolol in rat aorta and mesenteric artery: a role for nitric oxide and calcium entry blockade
    Fernanda B M Priviero
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil
    Clin Exp Pharmacol Physiol 33:448-55. 2006
    ..8. In conclusion, DL-propranolol relaxes arterial smooth muscle by mechanisms involving activation of the NO-cGMP pathway and calcium influx blockade, independent of beta-adrenoceptor blockade...
  88. ncbi The vasodilator potency of the endothelium-derived relaxing factor, L-S-nitrosocysteine, is impaired in conscious spontaneously hypertensive rats
    Stephen J Lewis
    Department of Physiology and Pharmacology, Institute of Comparative Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 7389, USA
    Vascul Pharmacol 44:476-90. 2006
    ....
  89. pmc The early effects of chronic hypoxia on the cardiovascular system in the rat: role of nitric oxide
    Martin P Walsh
    Department of Physiology, The Medical School, Birmingham B15 2TT, UK
    J Physiol 575:263-75. 2006
    ....
  90. ncbi Beneficial effects of isometric strength training on endothelial dysfunction in rats
    Hélène Figard
    UFR STAPS Besançon, 31 chemin de l Epitaphe 25000 Besançon, Universite de Franche Comte, France
    Appl Physiol Nutr Metab 31:621-30. 2006
    ..However, any benefits for age-related vascular dysfunction remain to be demonstrated...
  91. ncbi Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid
    Machha Ajay
    Department of Pharmacology, University of Malaya, Kuala Lumpur, Malaysia
    Pharmacol Res 55:385-91. 2007
    ..These effects of flavone results probably through enhanced bioactivity of nitric oxide released from the endothelium...
  92. ncbi Does the endothelium abolish or promote arterial vasomotion in rat mesenteric arteries? Explanations for the seemingly contradictory effects
    Dominique Seppey
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    J Vasc Res 45:416-26. 2008
    ..So far, contradictory results have emerged in the literature about the role of the endothelium in the onset and maintenance of vasomotion. Here our aim is to understand how the endothelium may either abolish or promote vasomotion...
  93. ncbi Vasorelaxation induced by the essential oil of Croton nepetaefolius and its constituents in rat aorta are partially mediated by the endothelium
    Pedro Jorge Caldas Magalhães
    Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brazil
    Fundam Clin Pharmacol 22:169-77. 2008
    ..Inhibition of other transduction pathways may be involved in the mediation of these effects...
  94. ncbi Role of nitric oxide and prostaglandin systems in lithium modulation of acetylcholine vasodilation
    Bahareh Rahimzadeh-Rofouyi
    Department of Pharmacology, School of Medicine, Medical Sciences Tehran University, Tehran, Iran
    J Cardiovasc Pharmacol 50:641-6. 2007
    ..NO synthesis or cyclooxygenase inhibition decreased vasorelaxation in both lower and higher doses of lithium, suggesting a role for NO and prostaglandin in this effect...
  95. ncbi Protective effects of ACE inhibitors on vascular endothelial dysfunction induced by exogenous advanced oxidation protein products in rats
    Shuang Xiu Chen
    Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, No 110 Xiang Ya Road, Changsha, Hunan 410078, China
    Eur J Pharmacol 584:368-75. 2008
    ....
  96. ncbi Effect of blood pressure on L-NAME-sensitive component of vasorelaxation in adult rats
    A Puzserova
    Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Physiol Res 56:S77-84. 2007
    ....
  97. ncbi Cerebral microvascular dilation during hypotension and decreased oxygen tension: a role for nNOS
    Holly D Bauser-Heaton
    Department of Cellular and Integrative Physiology, Indiana University Medical School, Indianapolis, Indiana 46202, USA
    Am J Physiol Heart Circ Physiol 293:H2193-201. 2007
    ..Therefore, nNOS predominantly increased NO during decreased periarteriolar oxygen tension, such as that during hypotension, but eNOS was the dominant source of NO for flow shear mechanisms...
  98. ncbi Vascular effects of long-term propranolol administration after chronic nitric oxide blockade
    Fernanda B M Priviero
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, P O Box 6111, 13084 971, Campinas, Sao Paulo, Brazil
    Eur J Pharmacol 571:189-96. 2007
    ..Additional mechanisms involving blockade of Ca2+ entry in the vascular smooth muscle and increase in NO bioavailability contributes to beneficial effects of long-term propranolol treatment...
  99. ncbi L-glutamine in vitro regulates rat aortic glutamate content and modulates nitric oxide formation and contractility responses
    David Schachter
    Dept of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Am J Physiol Cell Physiol 293:C142-51. 2007
    ..The results demonstrate that in vitro L-glutamine at its normal concentration in plasma can regulate rat aortic glutamate content and modulate NO formation and contractility responses of the thoracic aortic wall...
  100. ncbi Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta
    Francisco Aguirre-Crespo
    Facultad de Farmacia, Universidad Autonoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, 62210 Cuernavaca, Morelos, Mexico
    Life Sci 79:1062-8. 2006
    ....
  101. ncbi Native crystal structure of a nitric oxide-releasing lectin from the seeds of Canavalia maritima
    Carlos Alberto de Almeida Gadelha
    BioMol Lab Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceara, Brazil
    J Struct Biol 152:185-94. 2005
    ....

Research Grants66

  1. Pathogenesis of Exercise Pressor Reflex Dysfunction in Hypertension
    ANNA LEAL; Fiscal Year: 2009
    ....
  2. Role of Nitric Oxide in the Progression of Murine Cancer
    Rose Fife; Fiscal Year: 2002
    ..abstract_text> ..
  3. RENAL MEDULLARY NITRIC OXIDE AND BLOOD PRESSURE
    David Mattson; Fiscal Year: 2001
    ....
  4. Vascular tone and blood pressure control during exercise
    John Buckwalter; Fiscal Year: 2005
    ..This is an issue of fundamental importance that may have important implications for individuals with peripheral vascular disease. ..
  5. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  6. Old Westbury Neuroscience Research Institute MIDARP
    George Stefano; Fiscal Year: 2008
    ..abstract_text> ..
  7. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. Pulmonary Arterial Hypertension: Avian Model of Complex Vascular Lesion Developme
    ROBERT WIDEMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. MECHANISMS OF CUTANEOUS ACTIVE VASODILATION
    Dean Kellogg; Fiscal Year: 2008
    ..In addition, intradermal microdialysis will be combined with measurements of bioavailable NO by NO-selective amperometric electrode to define further how the NO system functions in cutaneous active vasodilation. ..
  10. FLAVANOL-RICH COCOA TO REVERSE VASCULAR DISEASE OF AGING
    Naomi Fisher; Fiscal Year: 2006
    ..She will be well-positioned to submit an application for an RO1 with results from this study. Therapeutic interventions aimed at restoring vascular endothelial function hold tremendous clinical promise. ..
  11. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    ..whether increased SOD1 in transgenic mice protects against hypertension similar to tempol; d. the role of NADPH oxidase, by measuring p22 phox expression and the effect of apocynin. ..
  12. Skeletal Muscle Microcirculation in Obese Zucker Rats
    Jefferson Frisbee; Fiscal Year: 2009
    ..abstract_text> ..
  13. Antioxidants and Development of Diabetic Nephropathy
    SHARON INMAN; Fiscal Year: 2007
    ..The ultimate goal of these studies is to establish better therapies that may include antioxidant therapy, to prevent the long term complications of diabetes, including nephropathy. [unreadable] [unreadable]..
  14. 2002 Myogenic Centennial Conference
    George Osol; Fiscal Year: 2002
    ....
  15. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
    ..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
  16. Muscle Pump and Chemical Dilation in Exercise Hyperemia
    William Schrage; Fiscal Year: 2004
    ..The strength of the proposed experiments is that we will manipulate both mechanical and chemical factors and assess their combined effects on muscle blood flow during acute and steady state exercise in humans. ..
  17. Cerebral Microvascular Endothelin Production
    Momoh Yakubu; Fiscal Year: 2003
    ..Our understanding of the mechanisms underlying the consequences of SAH will make it possible for early and appropriate intervention to prevent or reduce these complications from hemorrhagic stroke. ..
  18. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
    ..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
  19. Matrix Metalloproteinases in Gastric Injury
    Emily Robinson; Fiscal Year: 2008
    ..These facilities as well as close guidance and supervision from her sponsor will ensure success of the proposed project. [unreadable] [unreadable]..
  20. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 2003
    ..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
  21. Cerebral Arteriole Function during Hyperglycemic Stroke
    Marilyn Cipolla; Fiscal Year: 2009
    ....
  22. VENOARTERIAL SIGNALING IN THE UTERINE CIRCULATION
    George Osol; Fiscal Year: 2003
    ..These studies will provide new, quantitative information on the mechanisms by which molecular signals and pregnancy modulate venous permeability and signal transfer within the uterine circulation. ..
  23. REPERFUSION EFFECTS ON CEREBRAL ARTERY FUNCTION
    Marilyn Cipolla; Fiscal Year: 2003
    ..Therefore, Aim 3 will investigate the effects of two types of thrombolytic agents (tissue-type and urokinase) on cerebral artery function, including myogenic processes. ..
  24. Resistance Artery Adaptation in Hypertensive Pregnancy
    George Osol; Fiscal Year: 2009
    ..abstract_text> ..
  25. Neural Control of Sodium Balance in Hypertension: Exercise
    Noreen Rossi; Fiscal Year: 2009
    ..These studies will provide data to direct strategic pharmacologic and nonpharmacologic interventions for cardiovascular health that may be readily translated into clinical practice. ..
  26. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2008
    ..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..
  27. MECHANOTRANSDUCTION BY VASCULAR SMOOTH MUSCLE
    George Osol; Fiscal Year: 2002
    ....
  28. IGF-1, Oxidative Stress and Cardiovascular Aging
    Jun Ren; Fiscal Year: 2002
    ..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
  29. Endothelial Abnormalities in Obesity/Insulin Resistance
    CHRISTOPHER DESOUZA; Fiscal Year: 2005
    ..abstract_text> ..
  30. HYPERGLYCEMIA INHIBITION OF GLOMERULAR eNOS
    Shaoyou Chu; Fiscal Year: 2004
    ....
  31. Tetrahydrobiopterin in Hypoxia-Ischemia Induced Fetal Brain Dysfunction
    Jeannette Vasquez Vivar; Fiscal Year: 2008
    ..This information will likely define the use of tetrahydrobiopterin in the prevention and/or amelioration of H-I induced fetal brain dysfunction, which remains a major medical challenge. [unreadable] [unreadable] [unreadable]..
  32. Glial Activation Following Perinatal Hypoxia-Ischemia
    Mark Wainwright; Fiscal Year: 2008
    ..The convergent pharmacological and genetic approaches to understanding the mechanisms of glial activation in acute brain injury may lead to the identification of new therapeutic targets in perinatal asphyxia. ..
  33. Obesity/Insulin Resistance and Endothelial t-PA Release
    CHRISTOPHER DESOUZA; Fiscal Year: 2003
    ..abstract_text> ..
  34. Dynamics of Oxygen Uptake in Contracting Single Myocytes
    CASEY KINDIG; Fiscal Year: 2003
    ..abstract_text> ..
  35. AGING, EXERCISE AND ENDOTHELIAL FUNCTION
    CHRISTOPHER DESOUZA; Fiscal Year: 2002
    ..He and the host department will provide Dr. DeSouza all of the necessary resources to successfully complete his training. (End of Abstract) ..
  36. Renal tubular 20-HETE and EETs on sodium retention in
    Mong Heng Wang; Fiscal Year: 2009
    ..abstract_text> ..
  37. Aging, Chronic Disease and Skeletal Muscle Perfusion
    Timothy Musch; Fiscal Year: 2002
    ....
  38. Thrombin and CNS: Gastric Dysfunction after Head Trauma
    Gerlinda Hermann; Fiscal Year: 2006
    ..e., via an R01 funding program). ..
  39. TRANSGENIC STUDY VASCULAR ROLE OF NEUROPEPTIDE Y
    Michael Michalkiewicz; Fiscal Year: 2002
    ..The NPY overexpressing rats with well defined mutation of the NPY gene will provide a new transgenic animal model of hypertension; such a model should also be very useful for development of new therapies for treating this diseases. ..
  40. AT2 RECEPTOR MECHANISMS IN ANG II DEPENDENT HYPERTENSION
    Robert Carey; Fiscal Year: 2001
    ..The proposed studies will provide for the first time in any form of hypertension an understanding of the relevance and mediators of AT2 receptors in the long term control of blood pressure and kidney function. ..
  41. Mechanisms of Ductus Arteriosus Regulation
    JOHN JEFFREY REESE; Fiscal Year: 2010
    ..These studies will examine new roles for prostaglandins and their relationship with other vasoactive mediators during development. ..
  42. Vessel Remodeling During Ductus Arteriosus Closure
    Ronald I Clyman; Fiscal Year: 2010
    ..These studies should increase our understanding of the mechanisms that prevent the preterm DA from closing and remodeling after birth. ..
  43. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
    ..We will determine if a class of drugs called statins has the potential for reducing some of the deleterious consequences of compensatory mechanisms in the heart failure state. ..
  44. Cytokine and MAP Kinase Involvement in Neuropathic Pain
    Linda Sorkin; Fiscal Year: 2008
    ..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
  45. Role of inflammation in manganese-induced neurotoxicity
    NIKOLAY FILIPOV; Fiscal Year: 2004
    ..The long-term goal of the proposed studies is to understand the role of microglia and environmental contaminants in neurodegenerative diseases. ..
  46. Interleukin and the Magnocellular Neuroendocrine System
    Joan Summy Long; Fiscal Year: 2005
    ..abstract_text> ..
  47. NO& Epithelial Repair in Cryptosporidiosis
    Jody Gookin; Fiscal Year: 2006
    ..abstract_text> ..
  48. MORPHOLOGY AND FUNCTION OF BRAIN VESSELS
    GARY BAUMBACH; Fiscal Year: 2006
    ..These studies should provide important new insight into the mechanisms of vascular remodeling. [unreadable] [unreadable] [unreadable]..
  49. 20-HETE and its interaction with NO in pregnant rats
    Mong Heng Wang; Fiscal Year: 2005
    ..Ultimately, this knowledge can uncover new therapeutic targets and provide novel loci for the control and treatment of pregnancy-induced hypertension. ..
  50. HIGH SCHOOL HONORS RESEARCH PROGRAM
    STEPHEN PRYOR; Fiscal Year: 2007
    ..The facilities and state-of-the-art equipment provide the ideal setting for the learning of advanced laboratory techniques--a rare opportunity for high school students. ..
  51. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2006
    ..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
  52. MOLECULAR MECHANISMS OF DELAYED PRECONDITIONING
    RAKESH KUKREJA; Fiscal Year: 2006
    ..The information obtained from these studies may help us design novel therapies for protection of the heart against I/R injury. ..
  53. Proton as co-transmitter of neuronal signaling
    Martin Morad; Fiscal Year: 2006
    ..abstract_text> ..
  54. Behavioral Influences on Drug Tolerance
    James Smith; Fiscal Year: 2005
    ..Additionally, "multi-chamber" procedures will study generalization of those discriminative effects to performance of the same subjects in different circumstances. ..
  55. AT2 RECEPTORS IN BLOOD PRESSURE AND RENAL FUNCTION
    Robert Carey; Fiscal Year: 2004
    ..An understanding of the function of the AT2 receptor is necessary for an assessment of its potential role in the pathophysiology of hypertension and as a target for antihypertensive therapy. ..
  56. Alcohol modulates TLR2 signaling in airway epithelium
    KRISTINA BAILEY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. EXERCISE--MUSCLE BLOOD FLOW, VASCULAR ADAPTATIONS
    RICHARD MCALLISTER; Fiscal Year: 2001
    ..This comprehensive research program, ranging from the skeletal muscle microcirculation to the intact animals will improve our understanding of the cardiovascular response to exercise in health and disease. ..
  58. Vascular Biology: Aging and Endothelial Dysfunction
    CHRISTOPHER WOODMAN; Fiscal Year: 2005
    ..The Co-Sponsor, Elmer M. Price, Ph.D., is an established investigator in the field of molecular biology. The consulting mentor, Donald D. Heistad, M.D., is a recognized expert in the field of vascular molecular biology. ..
  59. Brain Manganese Deposition in High Risk Neonates
    Judy Aschner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. Microvascular Regulation During Intestinal Absorption
    HAROLD G BOHLEN; Fiscal Year: 2010
    ..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
  61. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  62. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  63. PROSTAGLANDIN SIGNALING IN FEMALE REPRODUCTION
    John Reese; Fiscal Year: 2005
    ..The results of these experiments will enhance the understanding of maternal-fetal PG signaling, and are likely to provide new insights into premature or dysfunctional labor in women. ..
  64. MICROVASCULAR CHARACTERISTICS OF DIABETES MELLITUS
    HAROLD BOHLEN; Fiscal Year: 2002
    ..Positive results will confirm that chronic insulin resistance predisposes the microvasculature to abnormalities of endothelial function. However, antioxidants and inhibition of beta II isoenzymes of PKC may protect endothelial function. ..
  65. Genetic Analysis of Vascular Aging
    Steven Miller; Fiscal Year: 2003
    ..abstract_text> ..