arginine

Summary

Summary: An essential amino acid that is physiologically active in the L-form.

Top Publications

  1. pmc Protein arginine methylation in mammals: who, what, and why
    Mark T Bedford
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, P O Box 389, Smithville, TX 78957, USA
    Mol Cell 33:1-13. 2009
  2. ncbi The L-arginine-nitric oxide pathway
    S Moncada
    Wellcome Research Laboratories, Beckenham, Kent, United Kingdom
    N Engl J Med 329:2002-12. 1993
  3. ncbi Protein arginine methyltransferases and cancer
    Yanzhong Yang
    Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, P O Box 389, Smithville, Texas 78957, USA
    Nat Rev Cancer 13:37-50. 2013
  4. ncbi Arginine methylation an emerging regulator of protein function
    Mark T Bedford
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Mol Cell 18:263-72. 2005
  5. ncbi Regulation of immune responses by L-arginine metabolism
    Vincenzo Bronte
    Cancer Center of Veneto Region, Department of Oncological and Surgical Sciences, Padua University, Via Gattamelata 64, Padua, Italy
    Nat Rev Immunol 5:641-54. 2005
  6. pmc Arginine catabolic mobile element encoded speG abrogates the unique hypersensitivity of Staphylococcus aureus to exogenous polyamines
    Gauri S Joshi
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Microbiol 82:9-20. 2011
  7. pmc Arginine metabolism: nitric oxide and beyond
    G Wu
    Departments of Animal Science, Medical Physiology, and Veterinary Anatomy and Public Health, and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Biochem J 336:1-17. 1998
  8. ncbi A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)
    Shao En Ong
    The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Protoc 1:2650-60. 2006
  9. pmc Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy
    S Armando Villalta
    Molecular, Cellular and Integrative Physiology Program, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095 1606, USA
    Hum Mol Genet 18:482-96. 2009
  10. pmc Arginase: a critical regulator of nitric oxide synthesis and vascular function
    William Durante
    Department of Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Clin Exp Pharmacol Physiol 34:906-11. 2007

Detail Information

Publications363 found, 100 shown here

  1. pmc Protein arginine methylation in mammals: who, what, and why
    Mark T Bedford
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, P O Box 389, Smithville, TX 78957, USA
    Mol Cell 33:1-13. 2009
    The covalent marking of proteins by methyl group addition to arginine residues can promote their recognition by binding partners or can modulate their biological activity...
  2. ncbi The L-arginine-nitric oxide pathway
    S Moncada
    Wellcome Research Laboratories, Beckenham, Kent, United Kingdom
    N Engl J Med 329:2002-12. 1993
  3. ncbi Protein arginine methyltransferases and cancer
    Yanzhong Yang
    Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, P O Box 389, Smithville, Texas 78957, USA
    Nat Rev Cancer 13:37-50. 2013
    There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian genomes, the protein products of which catalyse three types of arginine methylation--monomethylation and two types of dimethylation...
  4. ncbi Arginine methylation an emerging regulator of protein function
    Mark T Bedford
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Smithville, Texas 78957, USA
    Mol Cell 18:263-72. 2005
    b>Arginine methylation is now coming out of the shadows of protein phosphorylation and entering the mainstream, largely due to the identification of the family of enzymes that lay down this modification...
  5. ncbi Regulation of immune responses by L-arginine metabolism
    Vincenzo Bronte
    Cancer Center of Veneto Region, Department of Oncological and Surgical Sciences, Padua University, Via Gattamelata 64, Padua, Italy
    Nat Rev Immunol 5:641-54. 2005
    L-Arginine is an essential amino acid for birds and young mammals, and it is a conditionally essential amino acid for adult mammals, as it is important in situations in which requirements exceed production, such as pregnancy...
  6. pmc Arginine catabolic mobile element encoded speG abrogates the unique hypersensitivity of Staphylococcus aureus to exogenous polyamines
    Gauri S Joshi
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Microbiol 82:9-20. 2011
    ..aureus (CA-MRSA). We identified one gene within the USA-300-specific arginine catabolic mobile element (ACME) encoding a Spm/Spd N-acetyltransferase that is necessary and sufficient for ..
  7. pmc Arginine metabolism: nitric oxide and beyond
    G Wu
    Departments of Animal Science, Medical Physiology, and Veterinary Anatomy and Public Health, and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Biochem J 336:1-17. 1998
    b>Arginine is one of the most versatile amino acids in animal cells, serving as a precursor for the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline, glutamate, creatine and agmatine...
  8. ncbi A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)
    Shao En Ong
    The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Protoc 1:2650-60. 2006
    ..This procedure can be completed in 8 days...
  9. pmc Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy
    S Armando Villalta
    Molecular, Cellular and Integrative Physiology Program, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095 1606, USA
    Hum Mol Genet 18:482-96. 2009
    ..through the competition of arginase in M2a cells with iNOS in M1 cells for their common, enzymatic substrate, arginine. During the transition from the acute peak of mdx pathology to the regenerative stage, expression of IL-4 and IL-..
  10. pmc Arginase: a critical regulator of nitric oxide synthesis and vascular function
    William Durante
    Department of Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, Missouri 65212, USA
    Clin Exp Pharmacol Physiol 34:906-11. 2007
    1. Arginase is the focal enzyme of the urea cycle hydrolysing L-arginine to urea and L-ornithine...
  11. ncbi Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt
    Kazuyuki Yamagata
    Center for Tsukuba Advanced Research Alliance, Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Mol Cell 32:221-31. 2008
    ..Here we show a paradigm of FOXO1 regulation by the protein arginine methyltransferase PRMT1...
  12. pmc Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives
    Paulo C Rodriguez
    Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Immunol Rev 222:180-91. 2008
    ..L-arginine (L-Arg) is a conditionally essential amino acid that is fundamental for the function of T lymphocytes...
  13. pmc Recent advances in arginine metabolism: roles and regulation of the arginases
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Br J Pharmacol 157:922-30. 2009
    As arginine can serve as precursor to a wide range of compounds, including nitric oxide, creatine, urea, polyamines, proline, glutamate and agmatine, there is considerable interest in elucidating mechanisms underlying regulation of its ..
  14. ncbi Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo
    Pascale Kropf
    Department of Immunology, Faculty of Medicine, Imperial College London, UK
    FASEB J 19:1000-2. 2005
    ..by Th2 cytokines, is a hallmark of alternatively activated macrophages and is responsible for the hydrolysis of L-arginine into ornithine, the building block for the production of polyamines...
  15. ncbi Symmetrical and asymmetrical dimethylarginine as predictors for mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study
    Andreas Meinitzer
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
    Clin Chem 57:112-21. 2011
    ..Asymmetrical dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, has been linked to cardiovascular risk. The clinical role of its structural isomer symmetrical dimethylarginine (SDMA) remains largely unclear...
  16. pmc Crystal structure of the conserved core of protein arginine methyltransferase PRMT3
    X Zhang
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    EMBO J 19:3509-19. 2000
    Protein arginine methylation has been implicated in signal transduction, nuclear transport and transcription regulation...
  17. pmc Functional modularity of the arginine catabolic mobile element contributes to the success of USA300 methicillin-resistant Staphylococcus aureus
    Lance R Thurlow
    Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell Host Microbe 13:100-7. 2013
    ..causes the majority of skin and soft tissue infections (SSTIs) and is highly associated with the carriage of the arginine catabolic mobile element (ACME)...
  18. ncbi Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase
    Ken Y Lin
    Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif 94305, USA
    Circulation 106:987-92. 2002
    ..An endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), is elevated in patients with type 2 diabetes mellitus (DM). This study explored the mechanisms by which ADMA becomes elevated in DM...
  19. pmc Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
    Antonis Kirmizis
    Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 449:928-32. 2007
    ..An adjacent arginine residue (H3R2) is also known to be asymmetrically dimethylated (H3R2me2a) in mammalian cells, but its location ..
  20. pmc Novel functions of prototype foamy virus Gag glycine- arginine-rich boxes in reverse transcription and particle morphogenesis
    Erik Müllers
    Institut fur Virologie, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Fetscherstr 74, 01307 Dresden, Germany
    J Virol 85:1452-63. 2011
    ..Instead, it contains three glycine-arginine-rich boxes (GR boxes) in its C terminus that putatively represent a functional equivalent...
  21. pmc Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
    Paulo C Rodriguez
    Department of Microbiology, Stanley S Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Cancer Res 69:1553-60. 2009
    ..MDSC inhibit T-cell function by reducing the availability of L-arginine and are therefore considered an important tumor escape mechanism...
  22. ncbi Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive
    Ernesto Guccione
    Department of Experimental Oncology, European Institute of Oncology IEO, IFOM IEO Campus, Milan 20139, Italy
    Nature 449:933-7. 2007
    ..We previously observed that asymmetric di-methylation of histone H3 arginine 2 (H3R2me2a) counter-correlates with di- and tri- methylation of H3 lysine 4 (H3K4me2, H3K4me3) on human ..
  23. pmc Arginase: an emerging key player in the mammalian immune system
    Markus Munder
    Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany
    Br J Pharmacol 158:638-51. 2009
    The enzyme arginase metabolizes L-arginine to L-ornithine and urea. Besides its fundamental role in the hepatic urea cycle, arginase is also expressed the immune system of mice and man...
  24. pmc The role of DNA shape in protein-DNA recognition
    Remo Rohs
    Howard Hughes Medical Institute, Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biophysics, Columbia University, 1130 Saint Nicholas Avenue, New York, New York 10032, USA
    Nature 461:1248-53. 2009
    ..analysing the three-dimensional structures of protein-DNA complexes, here we show that the binding of arginine residues to narrow minor grooves is a widely used mode for protein-DNA recognition...
  25. ncbi Arginine methylation regulates the p53 response
    Martin Jansson
    Laboratory of Cancer Biology, Department of Clinical Pharmacology, Medical Sciences Division, University of Oxford, Old Road Campus Research Building, Old Road Campus, off Roosevelt Drive, Oxford, OX3 7DQ, UK
    Nat Cell Biol 10:1431-9. 2008
    ..We show that the protein arginine methyltransferase (PRMT) 5, as a co-factor in a DNA damage responsive co-activator complex that interacts with ..
  26. pmc Histone arginine methylation
    Alessandra Di Lorenzo
    The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, United States
    FEBS Lett 585:2024-31. 2011
    b>Arginine methylation is a common posttranslational modification (PTM). This type of PTM occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling proteins...
  27. ncbi Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders
    A McQuillin
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London, UK
    Mol Psychiatry 14:614-20. 2009
    ..The effect of the polymorphism is non-conservative and results in a glutamine to arginine change (Gln460Arg), which is likely to affect P2RX7 dimerization and protein-protein interactions...
  28. pmc srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization
    Shaoshi Guo
    Key Laboratory of Molecular and Developmental Biology, Center for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Biol Chem 285:35133-41. 2010
    ..Here we report that srGAP2 physically interacts with protein arginine methyltransferase 5 (PRMT5). srGAP2 localizes to the cytoplasm and plasma membrane protrusion...
  29. ncbi Production of the amino acids l-glutamate, l-lysine, l-ornithine and l-arginine from arabinose by recombinant Corynebacterium glutamicum
    Jens Schneider
    Chair of Genetics of Prokaryotes, Bielefeld University, Germany
    J Biotechnol 154:191-8. 2011
    ..l-Ornithine and l-arginine producing strains were constructed and shown to produce l-ornithine and l-arginine from arabinose when araBAD ..
  30. ncbi Melatonin blocks oxidative stress-induced increased asymmetric dimethylarginine
    You Lin Tain
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
    Free Radic Biol Med 49:1088-98. 2010
    ..Our findings reveal a mechanistic basis of DDAH downregulation by ROS and suggest that melatonin might be a potential therapy for various diseases with elevated cellular ADMA...
  31. pmc Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production
    Roman N Rodionov
    Department of Internal Medicine, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Biol Chem 285:5385-91. 2010
    ..We conclude that mitochondrially localized human AGXT2 is able to effectively metabolize ADMA in vivo resulting in decreased ADMA levels and improved endothelial NO production...
  32. pmc Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
    T Murohara
    Department of Medicine Cardiology and Department of Cardiothoracic Surgery and Biomedical Research, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Clin Invest 101:2567-78. 1998
    ..We first administered L-arginine, previously shown to augment endogenous production of NO, to normal rabbits with operatively induced hindlimb ..
  33. ncbi Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
    John Pernow
    Department of Medicine, Cardiology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm 17176, Sweden
    Cardiovasc Res 98:334-43. 2013
    ..Recently, the enzyme arginase has emerged as an important regulator of NO production by competing for l-arginine, which is a substrate for both arginase and NO synthase...
  34. pmc L-arginine availability regulates T-lymphocyte cell-cycle progression
    Paulo C Rodriguez
    Tumor Immunology Program, Stanley S Scott Cancer Center, Lousiana State University Health Sciences Center, Department of Pediatrics, New Orleans 70112, USA
    Blood 109:1568-73. 2007
    L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function...
  35. pmc Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation
    Brian D Young
    Department of Chemistry and Biochemistry and the Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
    Biochemistry 51:5091-104. 2012
    ..We found that Rps2 is substoichiometrically modified at arginine-10 by the Rmt1 methyltransferase...
  36. pmc Proteomic analysis reveals diverse classes of arginine methylproteins in mitochondria of trypanosomes
    John C Fisk
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14124, USA
    Mol Cell Proteomics 12:302-11. 2013
    b>Arginine (arg) methylation is a widespread posttranslational modification of proteins that impacts numerous cellular processes such as chromatin remodeling, RNA processing, DNA repair, and cell signaling...
  37. ncbi Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats
    You Lin Tain
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, College of Medicine, Taiwan
    J Pineal Res 49:390-8. 2010
    ..Plasma asymmetric dimethylarginine (ADMA) levels were elevated in SHR, combined with a reduction in plasma L-arginine to ADMA ratio (AAR)...
  38. pmc A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation
    Zhenbao Yu
    Bloomfield Center for Research on Aging, Segal Cancer Centre, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Mol Cell Biol 29:2982-96. 2009
    Protein arginine methyltransferase 1 (PRMT1) is the major enzyme that generates monomethylarginine and asymmetrical dimethylarginine...
  39. pmc TDRD3 is an effector molecule for arginine-methylated histone marks
    Yanzhong Yang
    The University of Texas MD Anderson Cancer Center, Science Park Research Division, P O Box 389, Smithville, TX 78957, USA
    Mol Cell 40:1016-23. 2010
    ..Furthermore, ChIP-seq analysis of TDRD3 reveals that it is predominantly localized to transcriptional start sites. Thus, TDRD3 is an effector molecule that promotes transcription by binding methylarginine marks on histone tails...
  40. ncbi Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
    J A Ballesteros
    Novasite Pharmaceuticals, Inc, San Diego, California 92121, USA
    J Biol Chem 276:29171-7. 2001
    ..49), Arg(3.50), and Glu(6.30) may constitute a common switch governing the activation of many rhodopsin-like G-protein-coupled receptors...
  41. ncbi Alternative splicing of pre-mRNAs of Arabidopsis serine/arginine-rich proteins: regulation by hormones and stresses
    Saiprasad Goud Palusa
    Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
    Plant J 49:1091-107. 2007
    ..Here, we show that the pre-mRNAs of Arabidopsis genes that encode serine/arginine-rich (SR) proteins, a conserved family of splicing regulators in eukaryotes, are extensively alternatively ..
  42. ncbi Suppression of protein interactions by arginine: a proposed mechanism of the arginine effects
    Tsutomu Arakawa
    Alliance Protein Laboratories, Thousand Oaks, CA 91360, United States
    Biophys Chem 127:1-8. 2007
    b>Arginine has been used to suppress protein aggregation and protein-protein or protein-surface interactions during protein refolding and purification...
  43. pmc Determination of dimethylarginine dimethylaminohydrolase activity in the kidney
    Y L Tain
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610 0274, USA
    Kidney Int 72:886-9. 2007
    ..Using this assay, we found that both superoxide and nitric oxide inhibit renal cortical DDAH activity in vitro...
  44. ncbi Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery
    S Futaki
    Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Biol Chem 276:5836-40. 2001
    ..Based on the fluorescence microscopic observations of mouse macrophage RAW264.7 cells, we found that various arginine-rich peptides have a translocation activity very similar to Tat-(48-60)...
  45. ncbi Extensive coupling of alternative splicing of pre-mRNAs of serine/arginine (SR) genes with nonsense-mediated decay
    Saiprasad G Palusa
    Department of Biology, Program in Molecular Plant Biology, Program in Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA
    New Phytol 185:83-9. 2010
    In Arabidopsis, pre-mRNAs encoding serine/arginine (SR) proteins, key regulators of constitutive and alternative splicing, are extensively alternatively spliced...
  46. ncbi Arginine methylation of the histone H3 tail impedes effector binding
    Aimee N Iberg
    The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Biol Chem 283:3006-10. 2008
    ..The intimate contact between H3R2 and these domain types leads to the hypothesis that methylation of this arginine residue antagonizes the binding of effector proteins to the N-terminal tail of H3...
  47. ncbi Trypsin cleaves exclusively C-terminal to arginine and lysine residues
    Jesper V Olsen
    Center for Experimental Bioinformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Mol Cell Proteomics 3:608-14. 2004
    ..peptide sequences can be required to conform to tryptic specificity, namely, cleavage exclusively C-terminal to arginine or lysine...
  48. pmc Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
    J Exp Med 204:2693-704. 2007
    ..of parasitized erythrocytes to microvascular endothelium and reduced levels of NO and its precursor, l-arginine. Endothelial function has not been characterized in SM but can be improved by l-arginine in cardiovascular ..
  49. pmc YjdE (AdiC) is the arginine:agmatine antiporter essential for arginine-dependent acid resistance in Escherichia coli
    Shimei Gong
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    J Bacteriol 185:4402-9. 2003
    ..resistance system 1 remains enigmatic, systems 2 and 3 are known to require external glutamate (system 2) and arginine (system 3) to function...
  50. ncbi Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential
    Christopher D Krause
    Department of Molecular Genetics, Microbiology, and Immunology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Pharmacol Ther 113:50-87. 2007
    Protein arginine N-methylation is a post-translational modification whose influence on cell function is becoming widely appreciated...
  51. pmc Arginine deprivation as a targeted therapy for cancer
    L Feun
    Hematology Oncology, University of Miami School of Medicine, 1201 N W 16th Street, Miami, FL 33136, USA
    Curr Pharm Des 14:1049-57. 2008
    ..b>Arginine deprivation is a novel approach to target tumors which lack argininosuccinate synthetase (ASS) expression...
  52. pmc Protein arginine methylation in parasitic protozoa
    John C Fisk
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA
    Eukaryot Cell 10:1013-22. 2011
    ..In yeast and humans, the posttranslational methylation of arginine residues in proteins affects myriad cellular processes, including transcription, RNA processing, DNA replication ..
  53. pmc Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat
    Haran Sivakumaran
    Division of Infectious Diseases, Queensland Institute of Medical Research, Herston, Queensland 4006, Australia
    J Virol 83:11694-703. 2009
    b>Arginine methylation of human immunodeficiency virus type 1 (HIV-1) Tat protein downregulates its key function in viral-gene transactivation...
  54. ncbi Arginine functionalized peptide dendrimers as potential gene delivery vehicles
    Kui Luo
    National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
    Biomaterials 33:4917-27. 2012
    ..In this study, we report the synthesis and characterization of arginine functionalized peptide dendrimer-based vectors ranging from 5th generation (G5A) to 6th generation (G6A) via ..
  55. pmc Structural insights into protein arginine symmetric dimethylation by PRMT5
    Litao Sun
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Proc Natl Acad Sci U S A 108:20538-43. 2011
    Symmetric and asymmetric dimethylation of arginine are isomeric protein posttranslational modifications with distinct biological effects, evidenced by the methylation of arginine 3 of histone H4 (H4R3): symmetric dimethylation of H4R3 ..
  56. ncbi Regulation of enzymes of the urea cycle and arginine metabolism
    Sidney M Morris
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Nutr 22:87-105. 2002
    ..Regulation of these enzymes is largely transcriptional in virtually all cell types. This review emphasizes recent information regarding roles and regulation of urea cycle and arginine metabolic enzymes in liver and other cell types.
  57. pmc MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA
    Jianmin Meng
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 285:27935-43. 2010
    ..Thus, surface charge differences at the two MD-2/TLR4 interfaces determine the species-specific activation of lipid IV(A)...
  58. ncbi Cyclization increases the antimicrobial activity and selectivity of arginine- and tryptophan-containing hexapeptides
    Margitta Dathe
    Institute of Molecular Pharmacology, Robert Roessle Strasse 10, D 13125 Berlin, Germany
    Biochemistry 43:9140-50. 2004
    b>Arginine- and tryptophan-rich motifs have been identified in antimicrobial peptides with various secondary structures...
  59. ncbi Arginine-rich cell-penetrating peptides
    Nathan Schmidt
    Department of Physics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    FEBS Lett 584:1806-13. 2010
    b>Arginine-rich cell-penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells...
  60. ncbi Deciphering arginine methylation: Tudor tells the tale
    Chen Chen
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nat Rev Mol Cell Biol 12:629-42. 2011
    ..b>Arginine methylation was discovered half a century ago, but the ability of methylarginine sites to serve as binding motifs ..
  61. ncbi The effects of arginine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation
    Tsutomu Arakawa
    Alliance Protein Laboratories, Thousand Oaks, CA 91360, USA
    Biochem Biophys Res Commun 304:148-52. 2003
    b>Arginine is one of the universal reagents that are effective in assisting refolding of recombinant proteins from inclusion bodies. The mechanism of the effects of arginine on refolding has remained, however, to be elucidated...
  62. pmc Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members
    Vasily V Vagin
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 23:1749-62. 2009
    ..Piwi proteins were found in complex with PRMT5/WDR77, an enzyme that dimethylates arginine residues...
  63. pmc A method for large-scale identification of protein arginine methylation
    Thomas Uhlmann
    T Cell Signalling Laboratory, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Mol Cell Proteomics 11:1489-99. 2012
    The lack of methods for proteome-scale detection of arginine methylation restricts our knowledge of its relevance in physiological and pathological processes...
  64. ncbi Asymmetric and symmetric dimethylarginines are of similar predictive value for cardiovascular risk in the general population
    Stefan Kiechl
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Atherosclerosis 205:261-5. 2009
    ..While increased plasma levels of ADMA have been reported in different cardiovascular disease states, its association with symmetric dimethylarginine (SDMA) has not been evaluated in a prospective population-based study...
  65. pmc Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS
    Dorothee Dormann
    Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, Munich, Germany
    EMBO J 31:4258-75. 2012
    ..Here, we show that arginine methylation modulates nuclear import of FUS via a novel TRN-binding epitope...
  66. ncbi Beneficial effects of L-arginine on reducing obesity: potential mechanisms and important implications for human health
    Jason R McKnight
    Department of Animal Science, Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Amino Acids 39:349-57. 2010
    Over the past 20 years, growing interest in the biochemistry, nutrition, and pharmacology of L-arginine has led to extensive studies to explore its nutritional and therapeutic roles in treating and preventing human metabolic disorders...
  67. ncbi Role of asymmetric dimethylarginine (ADMA) in diabetic vascular complications
    Sho ichi Yamagishi
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830 0011, Japan
    Curr Pharm Des 14:2613-8. 2008
    ..NO is synthesized from L-arginine via the action of NO synthase (NOS), which is known to be blocked by endogenous L-arginine analogues such as ..
  68. ncbi A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
    M C Marin
    Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 25:47-54. 2000
    ..Thus, inactivation of p53 family members may contribute to the biological properties of a subset of p53 mutants, and a polymorphic residue within p53 affects mutant behaviour...
  69. ncbi Arginine containing peptides as delivery vectors
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Rm 5406, Charlestown, MA 02129, USA
    Adv Drug Deliv Rev 55:281-94. 2003
    ..In this review, we specifically focus on arginine-containing MTS, and their properties, characteristics, in vitro and in vivo applications are discussed in detail.
  70. ncbi Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression
    Ayako Ojima
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, Japan
    Am J Pathol 182:132-41. 2013
    ..This study examined the effects of GLP-1 on reactive oxygen species (ROS) generation, gene expression of protein arginine methyltransfetase-1 (PRMT-1), an enzyme that mainly generates ADMA, and ADMA levels in human proximal tubular ..
  71. ncbi Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs
    Yulan Liu
    Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China
    Br J Nutr 100:552-60. 2008
    This study evaluated whether arginine (Arg) supplementation could attenuate gut injury induced by Escherichia coli lipopolysaccharide (LPS) challenge through an anti-inflammatory role in weaned pigs...
  72. pmc Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt
    Jun ichi Sakamaki
    Life Science Center of Tsukuba Advanced Research Alliance, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Proc Natl Acad Sci U S A 108:6085-90. 2011
    Protein arginine methylation is a common posttranslational modification catalyzed by a family of the protein arginine methyltransferases (PRMTs)...
  73. pmc Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system
    Michael J Tarry
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Proc Natl Acad Sci U S A 106:13284-9. 2009
    ..Similar TatBC-substrate complexes can be generated by an alternative in vitro reconstitution method and using a different substrate protein...
  74. ncbi Intracellular delivery of quantum dots mediated by a histidine- and arginine-rich HR9 cell-penetrating peptide through the direct membrane translocation mechanism
    Betty R Liu
    Department of Natural Resources and Environmental Studies, National Dong Hwa University, Shoufeng, Hualien, Taiwan
    Biomaterials 32:3520-37. 2011
    ..Here, we demonstrate that histidine- and arginine-rich CPPs (HR9 peptides) stably and noncovalently combined with QDs are able to enter into cells in an extremely ..
  75. pmc Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease
    Eva Schepers
    Department of Internal Medicine, Nephrology Division, University Hospital Gent, De Pintelaan 185, B 9000 Gent, Belgium
    Clin J Am Soc Nephrol 6:2374-83. 2011
    ..The present study further investigates the inflammatory character of SDMA compared with its structural counterpart asymmetric dimethylarginine (ADMA)...
  76. ncbi Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations
    Miranda L Tradewell
    Department of Neurology Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    Hum Mol Genet 21:136-49. 2012
    ..The data reported herein demonstrate the importance of protein arginine methylation in nuclear-cytoplasmic shuttling of FUS and abnormalities of ALS-causing mutants...
  77. pmc Engagement of arginine finger to ATP triggers large conformational changes in NtrC1 AAA+ ATPase for remodeling bacterial RNA polymerase
    Baoyu Chen
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Structure 18:1420-30. 2010
    ..We report the first crystal structure for such an ATPase, NtrC1 of Aquifex aeolicus, in which the catalytic arginine engages the γ-phosphate of ATP...
  78. pmc L-arginine deprivation impairs Leishmania major-specific T-cell responses
    Markus Munder
    Department of Hematology, University Hospital Heidelberg, Heidelberg, Germany
    Eur J Immunol 39:2161-72. 2009
    The amino acid L-arginine plays a crucial role in the regulation of immune responses...
  79. pmc A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients
    T S Yang
    Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University, Taoyuan 33305, Taiwan
    Br J Cancer 103:954-60. 2010
    ..carcinoma (HCC) cells are largely deficient of argininosuccinate synthetase and thus auxotrophic for arginine. This study aims to investigate the efficacy and pharmacodynamics of pegylated arginine deiminase (ADI-PEG 20), a ..
  80. ncbi Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria
    Irene Gramaglia
    La Jolla Bioengineering Institute, 505 Coast Boulevard, La Jolla, California 92037, USA
    Nat Med 12:1417-22. 2006
    ..We therefore conclude that low rather than high NO bioavailability contributes to the genesis of ECM...
  81. ncbi Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases
    Teru Ogura
    Division of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 862 0976, Japan
    J Struct Biol 146:106-12. 2004
    ..In this review, we will discuss what is known about these critical arginines and what can be concluded about their role in the function of AAA and AAA+ proteins...
  82. ncbi Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity
    Markus Munder
    Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Blood 105:2549-56. 2005
    The balance of arginine metabolism via nitric oxide synthase (NOS) or arginase is an important determinant of the inflammatory response of murine macrophages and dendritic cells...
  83. pmc Life on arginine for Mycoplasma hominis: clues from its minimal genome and comparison with other human urogenital mycoplasmas
    Sabine Pereyre
    Universite de Bordeaux, Laboratoire de Bactériologie EA 3671, Bordeaux, France
    PLoS Genet 5:e1000677. 2009
    ..We identified the three proteins constituting the arginine dihydrolase pathway. This pathway was found essential to promote growth in vivo...
  84. ncbi Dietary L-arginine supplementation enhances the reproductive performance of gilts
    Ronaldo D Mateo
    Texas Tech University, Lubbock, TX 79409, USA
    J Nutr 137:652-6. 2007
    b>Arginine is a common substrate for the synthesis of nitric oxide and polyamines that are crucial for placental angiogenesis and growth in mammals...
  85. ncbi A comprehensive model for the cellular uptake of cationic cell-penetrating peptides
    Falk Duchardt
    Interfaculty Institute for Cell Biology, University of Tubingen, Auf der Morgenstelle 15, 72076 Tubingen, Germany
    Traffic 8:848-66. 2007
    ..In this study, we provide evidence that the Antennapedia-homeodomain-derived antennapedia (Antp) peptide, nona-arginine and the HIV-1 Tat-protein-derived Tat peptide simultaneously use three endocytic pathways: macropinocytosis, ..
  86. pmc A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies
    Susan P Perrine
    Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, USA
    Blood 109:2571-8. 2007
    ..As butyrate has been shown to sensitize EBV(+) lymphoma cells in vitro to apoptosis induced by ganciclovir, arginine butyrate in combination with ganciclovir was administered in 15 patients with refractory EBV(+) lymphoid ..
  87. ncbi Formation of an ATP-DnaA-specific initiation complex requires DnaA Arginine 285, a conserved motif in the AAA+ protein family
    Hironori Kawakami
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 280:27420-30. 2005
    ..Sequence and structural analyses suggest that the DnaA Arg-285 residue is an arginine finger, an AAA+ family-specific motif that recognizes ATP bound to an adjacent subunit in a multimeric complex...
  88. ncbi Maternal nutrition and fetal development
    Guoyao Wu
    Department of Animal Science, Texas A and M University, Health Science Center, College Station, TX 77843, USA
    J Nutr 134:2169-72. 2004
    ..Promoting optimal nutrition will not only ensure optimal fetal development, but will also reduce the risk of chronic diseases in adults...
  89. pmc Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis
    Manuel Modolell
    Department of Cellular Immunology, Max Planck Institute for Immunobiology, Freiburg, Germany
    PLoS Negl Trop Dis 3:e480. 2009
    ..The high arginase activity causes local depletion of L-arginine, which impairs the capacity of T cells in the lesion to proliferate and to produce interferon-gamma, while T ..
  90. pmc How does the royal family of Tudor rule the PIWI-interacting RNA pathway?
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Genes Dev 24:636-46. 2010
    ..Although Tud domains in Tud family members are known to be sDMA-binding modules, involvement of the Tudor family at the molecular level in the piRNA pathway has only recently come into focus...
  91. ncbi Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells
    H Li
    Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Am J Physiol Endocrinol Metab 280:E75-82. 2001
    Endothelial cells (EC) metabolize L-arginine mainly by arginase, which exists as two distinct isoforms, arginase I and II...
  92. pmc Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes
    Macus Tien Kuo
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Oncotarget 1:246-51. 2010
    ..shown that a subset of human cancers, notably, melanoma and hepatocellular carcinoma (HCC) are auxotrophic for arginine (Arg), because they do not express argininosuccinate synthetase (ASS), the rate-limiting enzyme for the ..
  93. ncbi Asymmetrical dimethylarginine: the Uber marker?
    John P Cooke
    Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, Calif 94305, USA
    Circulation 109:1813-8. 2004
  94. ncbi Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems
    Fredrik Palm
    Division of Nephrology and Hypertension, Georgetown University, 3800 Reservoir Road N W, Washington, DC 20007, USA
    Am J Physiol Heart Circ Physiol 293:H3227-45. 2007
    ....
  95. ncbi Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway
    Patrick Vallance
    BHF Laboratories, Division of Medicine, University College London, Rayne Institute, 5 University St, London WC1 6JJ, UK
    Arterioscler Thromb Vasc Biol 24:1023-30. 2004
    ..This article describes the biology of ADMA and the implications for cardiovascular physiology and pathophysiology...
  96. pmc The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages
    V Iniesta
    Parasitology Unit, Department of Medicine and Animal Health, University of Extremadura, , Spain
    J Exp Med 193:777-84. 2001
    ..We have found that N(omega)-hydroxy-l-arginine (LOHA), a physiological inhibitor of arginase, controls cellular infection and also specifically inhibits ..
  97. ncbi Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates
    Wenjuan Shi Jobgen
    Texas A and M University, College Station, TX 77843, USA
    J Nutr Biochem 17:571-88. 2006
    Nitric oxide (NO) is synthesized from L-arginine by NO synthase in virtually all cell types. Emerging evidence shows that NO regulates the metabolism of glucose, fatty acids and amino acids in mammals...
  98. ncbi The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans
    S S Wolf
    Bayer Schering Pharma AG, Global Drug Discovery, TRG Women s Healthcare, Muellerstr 178, 13353, Berlin, Germany
    Cell Mol Life Sci 66:2109-21. 2009
    Information about the family of protein arginine methyltransferases (PRMTs) has been growing rapidly over the last few years and the emerging role of arginine methylation involved in cellular processes like signaling, RNA processing, gene ..
  99. pmc ADP-ribosylation of arginine
    Sabrina Laing
    Campus Forschung, 2 OG Rm 02 0058, Institute of Immunology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Germany
    Amino Acids 41:257-69. 2011
    b>Arginine adenosine-5'-diphosphoribosylation (ADP-ribosylation) is an enzyme-catalyzed, potentially reversible posttranslational modification, in which the ADP-ribose moiety is transferred from NAD(+) to the guanidino moiety of arginine...
  100. ncbi Down-regulation of asymmetric arginine methylation during replicative and H2O2-induced premature senescence in WI-38 human diploid fibroblasts
    Yongchul Lim
    Department of Cellular and Developmental Biology, Division of Brain Korea 21 Program for Biomedical Sciences, Korea University, College of Medicine, Seoul, Korea
    J Biochem 144:523-9. 2008
    Protein arginine methylation is one of the post-translational modifications which yield monomethyl and dimethyl (asymmetric or symmetric) arginines in proteins...
  101. pmc Early contacts between substrate proteins and TatA translocase component in twin-arginine translocation
    Julia Fröbel
    Institute of Biochemistry and Molecular Biology, Zentrum für Biochemie und Molekulare Zellforschung ZBMZ, Faculty of Biology, University of Freiburg, Freiburg, Germany
    J Biol Chem 286:43679-89. 2011
    Twin-arginine translocation (Tat) is a unique protein transport pathway in bacteria, archaea, and plastids...

Research Grants71

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..therapy among transfusion dependent beta-thalassemia patients with abnormal resting ejection fractions, 2) Arginine and sidenafil will both show clinical efficacy in the treatment of pulmonary hypertension, 3) Nine months of ..
  3. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..cell-free hemoglobin, lactate dehydrogenase), inflammation (high-sensitivity CRP), dysfunction of NO metabolism (arginine, ornithine &citrulline, vitamin C, tetrahydrobiopterin, dihydrobiopterin,) and night time hypoxia (overnight ..
  4. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..linked to DFO or to a new oral chelator derived from deferrithiocin;if needed to enhance cell uptake, nona-arginine -linked peptide will be used. 2...
  5. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..The most important modifications of histones and DNA include: histone lysine and arginine methylation;lysine acetylation;DNA cytosine methylation;and histone sumoylation, ubiquitination, ADP-ribosylation ..
  6. Epigenetic mechanisms relevant to the pathogenesis of ALS
    Neil W Kowall; Fiscal Year: 2013
    ..We recently reported that the amino acid L-arginine slows disease progression in mutant SOD1 (G93A) transgenic ALS mice...
  7. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..The mutation, substitutes cysteine for arginine (R611C) at a highly conserved residue of the second epidermal growth factor precursor domain in the LDL receptor ..
  8. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..Female sex hormone, estrogen, is involved in pathogenesis by enhancing production of peptidyl arginine deiminase (PAD) enzyme that leads to citrullination of synovial proteins...
  9. Alternative Macrophage Activation Limits Immunopathology
    DEBROSKI R HERBERT; Fiscal Year: 2011
    ..AAMF selectively express arginases (isoforms I and II) to metabolize L-arginine into polyamines and proline, implicating AAMF as regulators of cellular proliferation and fibrosis during the ..
  10. Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22
    Yaya Wang; Fiscal Year: 2013
    ..One such genetic variant is the PTPN22 C1858T, which leads to an Arginine to Tryptophan (R->W) change in the Lymphoid tryrosine phosphatase (Lyp)...
  11. Arginine Availability and Metabolism in the Immune Evasion of H. pylori
    Keith T Wilson; Fiscal Year: 2013
    ..pylori fails to eradicate the organism. Our work has focused on the role of L-arginine (L-Arg) in the macrophage response to H. pylori...
  12. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..The role of nitric oxide in the statin effect will be determined by employing L-NMMA (NG-monomethyl L-arginine), an inhibitor of the NO synthase pathway...
  13. Citrulline to Prevent or Mitigate Acute Lung Injury in Severe Sepsis
    Todd W Rice; Fiscal Year: 2013
    ..Inflammation results in plasma citrulline deficiency which leads to arginine deficiency and uncoupling of nitric oxide synthase (NOS)...
  14. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..glutathione will lower levels of inflammatory markers, and whether the presence or absence of supplemental arginine will add to the effectiveness of the glutathione therapy...
  15. Novel Collagen II Alternative Transcripts and Mouse Skeletal Development
    Audrey McAlinden; Fiscal Year: 2010
    ..IID mRNA contains an extra three nucleotides at the end of exon 2 that encodes either tryptophan (in human) or arginine (in mouse) without altering the subsequent protein reading frame...
  16. KCNQ Channels and Vasoconstrictor Signal Transduction
    Kenneth L Byron; Fiscal Year: 2013
    ..that suggest that regulation of arterial myocyte excitability by physiological vasoconstrictor concentrations of arginine vasopressin (AVP, 10-100 pM) involves protein-kinase C-dependent suppression of KCNQ5 channel activity...
  17. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
    ..in mosaic 2 [unreadable]m stacks equal to158 terabytes, 3) Reconstruct the hypothalamic- projections found with arginine-vasopressin and a Williams syndrome gene product to a subset of limbic targets from serial images into a single ..
  18. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
    ..whether inhibition of neurotransmission is NO-specific by repeating studies after NOS inhibition with nitro-L-arginine (NLA) and after repletion of NO during perfusion with NLA+sodium nitroprusside (SNP)...
  19. Mechanism of eNOS Uncoupling in the Renal Microvasculature
    YVES CLAUDE GORIN; Fiscal Year: 2013
    ..synthase (eNOS), which generates nitric oxide (NO) in the presence of optimal concentrations of the substrate L-arginine and the cofactor tetrahydrobiopterin (BH4)...
  20. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation
    Xianxin Hua; Fiscal Year: 2013
    ..Menin interacts with PRMT5, a histone arginine methytransferase that represses gene transcription...
  21. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Veena Taneja; Fiscal Year: 2013
    ..Female sex hormone, estrogen, is involved in pathogenesis by enhancing production of peptidyl arginine deiminase (PAD) enzyme that leads to citrullination of synovial proteins...
  22. CONTROL OF EUCARYOTIC FUNCTION BY METHYLATION
    Steven G Clarke; Fiscal Year: 2013
    ..are controlled by methylation reactions, focusing on the enzymes that catalyze the modification of protein arginine, lysine, and isoaspartyl residues...
  23. The Role of Carboxypeptidase B and its Substrates in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    ..These substrates are involved in inflammatory pathways including chemotaxis and T cell activation. CPB removes arginine residues from the C-terminus of these substrates and is thereby postulated to modulate biologic function of these ..
  24. Regulation of Lung Fibrosis by Alternatively Activated Macrophages and Arginase-1
    ROBERT MATTHEW TIGHE; Fiscal Year: 2013
    ..It has the potential to directly mediate fibrogenesis. Arginase-1 is responsible for the conversion of L-arginine to proline and polyamines...
  25. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..cortiocotropin releasing hormone (CRH), BDNF, GABA, GLU, neuronal NO (nNOS), estrogen receptors (ER)a and p, and arginine vasopressin (AVP))...
  26. Moraxella catarrhalis: virulence-based prevention
    Timothy F Murphy; Fiscal Year: 2013
    ..M. catarrhalis has a strict growth requirement for arginine. We showed that OppA transports arginine-containing peptides...
  27. Is symmetrical dimethylation of Arginine 2 of Histone H3 used as an epigenetic si
    Marjorie A Oettinger; Fiscal Year: 2010
    ..preference for binding H3 that is concurrently trimethylated on lysine 4 and symmetrically dimethylated at arginine 2 (H3R2me2s/K4me3)...
  28. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    JAMES ANTHONY SHEERIN MULDOWNEY; Fiscal Year: 2013
    ..from the vasculature in response to numerous neurohormones including acetylcholine, catecholamines, substance P, arginine vasopressin and bradykinin...
  29. REGULATION OF 15N UREA ISOTOPOMERS PRODUCTION
    Itzhak Nissim; Fiscal Year: 2013
    ..During the current funding period we found that agmatine (AGM), the product of arginine decarboxylase, elevates hepatic [cAMP] and stimulates both ureagenesis and FAO...
  30. Novel High Affinity and Long-Acting Bovine FSH Analogs for Veterinary Superovulat
    BRUCE DALE WEINTRAUB; Fiscal Year: 2012
    ..Develop novel high affinity recombinant bFSH superagonist analogs by minimal 4-5 arginine and/or lysine site-directed mutagenesis to produce a more potent and efficacious molecule with possible delayed ..
  31. H. pylori induced DNA Damage and Immune Dysregulation
    Keith T Wilson; Fiscal Year: 2013
    ..apoptosis;and 2.) inhibition of nitric oxide (NO) synthesis, by inhibition of L-arginine (L-Arg)-dependent inducible nitric oxide (NO) synthase (iNOS) protein translation...
  32. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation.
    Xianxin Hua; Fiscal Year: 2010
    ..Menin interacts with PRMT5, a histone arginine methytransferase that represses gene transcription...
  33. Epigenetic regulation of liver transporters
    Frederick J Suchy; Fiscal Year: 2013
    ..In Aim 1 we will focus on how CARM 1 (coactivator-associated arginine methyl transferase) and SRC-2 (steroid receptor co-activator 2) and other coactivators are recruited to the ..
  34. Aquaporin-2 (AQP2) Regulation by AMP-activated kinase(AMPK) in the Kidney Collec
    Mohammad Al-Bataineh; Fiscal Year: 2012
    ..The hormone arginine vasopressin (AVP;or antidiuretic hormone) is secreted from the hypothalamus/pituitary as a normal response to ..
  35. SPLICING OF MRNA PRECURSORS
    Michael R Green; Fiscal Year: 2013
    ..A variety of mammalian protein splicing factors contain an arginine-serine rich (RS) domain required to promote splicing...
  36. Regulation of NETosis in antibacterial lung defense
    EILEEN REMOLD-O'DONNELL; Fiscal Year: 2013
    ..of PAD4 (peptidylarginine deiminase-4), the essential enzyme that deiminates (citrullinates) histone tail arginine residues, causing chromatin decondensation, expansion of the nucleus, and extrusion of NETs...
  37. Effect of Diet on Inflammation in Sicke Cell Mice
    Jacqueline M Hibbert; Fiscal Year: 2010
    ..we have found that in asymptomatic sickle cell children and a transgenic sickle cell mouse model, plasma L-arginine concentration is significantly low compared with healthy controls...
  38. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2013
    ..ADMA is generated intracellularly by protein arginine methyltransferases (PRMTs), metabolized by dimethylarginine dimethylaminohydrolases (DDAHs) and exported by ..
  39. L-arginine supplement for the prevention of calcineurin inhibitor nephrotoxicity
    W Ray Kim; Fiscal Year: 2011
    ..Once it is established, there is no effective treatment for calcineurin inhibitor-induced renal insufficiency. L-arginine, a precursor of NO, has been shown to reverse the effects of calcineurin inhibitors on the vascular system as ..
  40. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith T Wilson; Fiscal Year: 2013
    ..We have been focusing on the role of the semi-essential amino acid, L-arginine (L-Arg) as a complementary and alternative medicine...
  41. TSQ Vantage Bundle with Acquity UltraPerformance LC
    Nicolaas E Deutz; Fiscal Year: 2010
    ..projects all rely on one or both of two core methodologies: utilization of (i) L-citrulline and related arginine pathway substrates as metrics of intestinal health and activity;and (ii) stable (heavy) isotopomers of L-..
  42. REGULATION OF 15N UREA ISOTOPOMERS PRODUCTION
    Itzhak Nissim; Fiscal Year: 2009
    ..During the current funding period we found that agmatine (AGM), the product of arginine decarboxylase, elevates cellular [cAMP] and stimulates hepatic ureagenesis as well as FAO...
  43. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2012
    ..Virtually nothing is known on how alcohol modulates ASS expression and how the L-arginine "recycling" pathway may impact NO generation and liver injury...
  44. Functional role of RAG2 H3K4me3 interaction in V(D)J recombination
    Marjorie A Oettinger; Fiscal Year: 2013
    ..preference for binding H3 that is concurrently trimethylated on lysine 4 and symmetrically dimethylated at arginine 2 (H3R2me2s/K4me3)...
  45. Viral mechanisms of adipocyte dysfuntion: Role of Vpr.
    Ashok Balasubramanyam; Fiscal Year: 2012
    ..lipid and energy metabolism: one defective in the LQQLL coregulator binding site, and the other defective in the arginine-rich C-terminus motif associated with Vpr's cell cycle arrest effects in vitro...
  46. NITRIC OXIDE AND OXYGENATION IN DIABETIC KIDNEYS
    NILS AXEL FREDRIK PALM; Fiscal Year: 2010
    ..and DDAH-II expressed in the juxtaglomerular apparatus, and the intracellular availability of the NOS substrate arginine which it self depends on the plasma arginine concentration (regulated primarily by cellular uptake of arginine in ..
  47. The Contribution of Protein Methylation in Systemic Lupus Erythematosus
    Hester A Doyle; Fiscal Year: 2011
    ..occurs with lupus, protein methylation reactions, such as the conversion of aspartic acid to isoaspartic acid and arginine methylation, increase...
  48. Sex Differences in the Roles of Oxytocin and Vasopressin in Social Withdrawal
    Michael Q Steinman; Fiscal Year: 2013
    ..Oxytocin (OT) and arginine vasopressin (AVP) are related neuroproteins that play important roles in social interactions...
  49. Characterization of the NOD2 NBD domain and role in chronic inflammation
    Jae W Dugan; Fiscal Year: 2013
    ..in Blau syndrome cluster in the NOD domain (the most frequent being a glutamine at position 334 instead of an arginine, indicated as R334Q)...
  50. The role of a novel AIF-associated nuclease PAAN1 in neuronal injury
    Yingfei Wang; Fiscal Year: 2013
    ..PARP-1-dependent cell viability high-throughput screening, thirteen hits including AIF interactor 18 and protein arginine methyltransferase 6 (PRMT6) were identified...
  51. Imaging of gene delivery in the central nervous system
    Assaf A Gilad; Fiscal Year: 2010
    ..genes of the LRP-type, and the other will contain genes that are similar to protamine (a protein with high arginine concentration). The libraries will be screened for optimized reporter genes...
  52. Vascular and Neural Mechanisms of Serotonin-induced Reduction in Blood Pressure
    Stephanie W Watts; Fiscal Year: 2013
    ..in blood pressure is dependent on the activity of nitric oxide synthase (NOS) because the NOS inhibitor N-nitro-L-arginine (LNNA) abolished 5-HT-induced chronic fall in blood pressure in multiple situations...
  53. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2010
    ..The first DH allele will substitute arginine and other positively charged amino acids from inverted reading frame 1 for the tyrosine and glycine that are ..
  54. Preventive of Bile Acid-Induced Colonic Oxidative DNA Damage
    Claire Margaret Payne; Fiscal Year: 2010
    ..129 mice) developed in our laboratory;2) NOS-/- k.o./DOC mouse model;3) arginine-enhanced colon tumor ApcMin/+ mouse model developed in our laboratory;4) the AOM mouse model of colon ..
  55. Role of the Angiogenic Chemokine, CXCL5, in Prostate Cancer
    Liz Simon; Fiscal Year: 2012
    ..CXCL5 is a member of CXC family of chemokines with the three amino acid motif, glutamic acid-leucine-arginine (ELR+) and is a potent angiogenic promoter...
  56. AMINO-CARBONYL REACTIONS IN THE AGING HUMAN LENS
    Vincent M Monnier; Fiscal Year: 2013
    ..accumulate all ascorbylation products present in the human lens, 3) the discovery that both oral and topical L-arginine is a potent inhibitor of crystallin damage in vivo, 4) the successful development of the LEGSKO (lens GSH ..
  57. Bacterial peptidylarginine deiminase, a link between gums and joint disease
    JAN S POTEMPA; Fiscal Year: 2013
    ..gingivalis peptidylarginine deiminase (PPAD), which has the ability to convert arginine residues in proteins to citrulline...
  58. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism
    Jeffrey A Kline; Fiscal Year: 2013
    ..through the release of arginase-1, which depletes the endothelial nitric oxide synthase (eNOS) substrate, L-arginine. Free hemoglobin also activates platelets and damages their mitochondrial oxidative metabolism, which may cause ..
  59. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John H Eisenach; Fiscal Year: 2012
    ..resistance during mental stress and isometric handgrip exercise than individuals with haplotypes homozygous for arginine (Arg16) + glutamine (Gln27) (haplotype 2) and Gly16 + Gln27 (haplotype 3)...
  60. Arginine, Nitric Oxide, and Severe Malaria
    JOE BRICE WEINBERG; Fiscal Year: 2012
    ..oxide (NO), impaired mononuclear cell NO synthase 2 (NOS2) expression, and very low levels of the NOS substrate arginine. We concluded that NO and NOS2 are protective against development of severe malaria...
  61. Regulation of a Novel Trypanosome RNA Binding Protein by Arginine Methylation
    Kaylen Lott; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this project is to identify mechanisms by which arginine (arg) methylation regulates gene expression in kinetoplastid parasites. Kinetoplastids, including Trypanosoma brucei, T...
  62. Genetic Basis of Virulence of Community MRSA Clone USA300
    Henry F Chambers; Fiscal Year: 2010
    ..Specific aims are: 1) To identify virulence determinants in the arginine catabolic mobile element (ACME), which is unique to USA300. Deletion of ACME reduces virulence...
  63. Functional studies of the Fragile X Mental Retardation Protein: switching from re
    Mihaela Mihailescu; Fiscal Year: 2009
    ..Biochemical studies have determined that FMRP uses its arginine-glycine-glycine (RGG) box to bind with high affinity to RNA sequences that have the potential to form G ..
  64. Improved actions of nitrates and statins with L-arginine
    Ruth Caldwell; Fiscal Year: 2003
    ..therapy [pravastatin (PRA) or simvastatin (SIM)] for unstable angina and stroke, by their combination with L-arginine (L-arginine)...
  65. Severe falciparum malaria: mechanisms of hypoargininemia
    Bert Lopansri; Fiscal Year: 2006
    The goal of this project is to investigate the role of L-arginine as substrate for nitric oxide synthesis in the pathophysiology of severe falciparum malaria...
  66. Dosimetry of Lipid-Derived Amino Acid Adducts by LC/MS
    Ian Blair; Fiscal Year: 2006
    ..We have now made the exciting observation that 4-oxo-2-nonenal efficiently forms adducts with the amino acid arginine. Previous studies have demonstrated 4-hydroxy-2-nonenal can induce covalent modifications with model amino acids...
  67. NUTRITIONAL MODIFICATION OF CANCER CELL GROWTH
    CRAIG BYUS; Fiscal Year: 1990
    ..These specific amino acids are ornithine, arginine, and lysine...
  68. VACUOLE FUNCTION IN NEUROSPORA
    Richard Weiss; Fiscal Year: 1993
    ..b>Arginine, ornithine and a number of other amino acids are sequestered in the vacuoles in this organism...
  69. Metabolism of Endothelial Dysfunction in Renal Disease
    Leticia Castillo; Fiscal Year: 2006
    ..Three metabolic pathways have a major role in the regulation of endothelial function: the L-arginine-Nitric Oxide (NO) pathway, the methionine-homocysteine cycle and the asymmetric dimethylarginine (ADMA)...
  70. STUDIES ON ENDOTHELIAL DYSFUNCTION IN HEART FAILURE
    Stuart Katz; Fiscal Year: 2004
    ..agonists and shear stress in patients with heart failure is attributable to reduced synthetic activity of the L-arginine-nitric oxide metabolic pathway and that endothelial dysfunction in heart failure is reversible with physical ..
  71. CYTOSTATIC ROLE OF THE ARGININE-NITRIC OXIDE PATHWAY
    Louis Ignarro; Fiscal Year: 2001
    ..We have found that N/G-hydroxy-L- arginine (NOHA), an intermediate in the oxidation of arginine to NO + citrulline, is synthesized and released from cells ..