gamma aminobutyric acid

Summary

Summary: The most common inhibitory neurotransmitter in the central nervous system.

Top Publications

  1. ncbi Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:215-29. 2005
  2. ncbi Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse
    Nobuaki Tamamaki
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Comp Neurol 467:60-79. 2003
  3. ncbi Excitatory actions of gaba during development: the nature of the nurture
    Yehezkel Ben-Ari
    Institut de Neurobiologie de la Méditerranée INMED, INSERM Unit 29, Parc Scientifique de Luminy, 13273 Marseille Cedex 09, France
    Nat Rev Neurosci 3:728-39. 2002
  4. ncbi Is there more to GABA than synaptic inhibition?
    David F Owens
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Building 36, Room 3C09, 36 Convent Drive, Bethesda, Maryland 20892 4092, USA
    Nat Rev Neurosci 3:715-27. 2002
  5. ncbi Tonically active GABA A receptors: modulating gain and maintaining the tone
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Trends Neurosci 27:262-9. 2004
  6. ncbi Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3TH, UK
    Nature 421:844-8. 2003
  7. ncbi GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nat Neurosci 6:484-90. 2003
  8. pmc Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons
    Shibeshih Belachew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010 2970, USA
    J Cell Biol 161:169-86. 2003
  9. ncbi GABA and its agonists improved visual cortical function in senescent monkeys
    Audie G Leventhal
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Science 300:812-5. 2003
  10. ncbi Inhibitory threshold for critical-period activation in primary visual cortex
    M Fagiolini
    Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, Saitama, Japan
    Nature 404:183-6. 2000

Detail Information

Publications338 found, 100 shown here

  1. ncbi Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors
    Mark Farrant
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 6:215-29. 2005
    ..In this review, we consider the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability...
  2. ncbi Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse
    Nobuaki Tamamaki
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Comp Neurol 467:60-79. 2003
    ..4% of the GFP-positive cells. They accounted for 6.5% in layer I. In accord with unidentified GFP-positive cells, many medium-sized spherical somata emitting intense GFP fluorescence were observed in layer I...
  3. ncbi Excitatory actions of gaba during development: the nature of the nurture
    Yehezkel Ben-Ari
    Institut de Neurobiologie de la Méditerranée INMED, INSERM Unit 29, Parc Scientifique de Luminy, 13273 Marseille Cedex 09, France
    Nat Rev Neurosci 3:728-39. 2002
    ..As key elements of this cascade are activity dependent, the formation of inhibition adds an element of nurture to the construction of cortical networks...
  4. ncbi Is there more to GABA than synaptic inhibition?
    David F Owens
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Building 36, Room 3C09, 36 Convent Drive, Bethesda, Maryland 20892 4092, USA
    Nat Rev Neurosci 3:715-27. 2002
    ..The unique features of the early-appearing GABA signalling systems might help to explain how GABA acts as a developmental signal...
  5. ncbi Tonically active GABA A receptors: modulating gain and maintaining the tone
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Trends Neurosci 27:262-9. 2004
    ....
  6. ncbi Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3TH, UK
    Nature 421:844-8. 2003
    ..We conclude that the diversity of interneurons, innervating distinct domains of pyramidal cells, emerged to coordinate the activity of pyramidal cells in a temporally distinct and brain-state-dependent manner...
  7. ncbi GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nat Neurosci 6:484-90. 2003
    ..Reducing the tonic conductance in interneurons enhanced their excitability and the inhibitory drive to pyramidal cells. These results point to a role for cell type-dependent tonic inhibition in regulating cortical excitability...
  8. pmc Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons
    Shibeshih Belachew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010 2970, USA
    J Cell Biol 161:169-86. 2003
    ..These data show that at least a subpopulation of postnatal NG2-expressing cells are CNS multipotent precursors that may underlie adult hippocampal neurogenesis...
  9. ncbi GABA and its agonists improved visual cortical function in senescent monkeys
    Audie G Leventhal
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Science 300:812-5. 2003
    ..Many treated cells in area V1 of old animals displayed responses typical of young cells. The present results have important implications for the treatment of the sensory, motor, and cognitive declines that accompany old age...
  10. ncbi Inhibitory threshold for critical-period activation in primary visual cortex
    M Fagiolini
    Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, Saitama, Japan
    Nature 404:183-6. 2000
    ..A threshold level of inhibition within the visual cortex may thus trigger, once in life, an experience-dependent critical period for circuit consolidation, which may otherwise lie dormant...
  11. ncbi Activation of GABAA receptors: views from outside the synaptic cleft
    Joseph Glykys
    Interdepartmental PhD Program for Neuroscience, The David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Neuron 56:763-70. 2007
    ..These same receptors constitute important and specific targets for various endogenous and exogenous neuroactive compounds and possible therapeutic targets...
  12. ncbi Critical period plasticity in local cortical circuits
    Takao K Hensch
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198, Japan
    Nat Rev Neurosci 6:877-88. 2005
    ..The reactivation of this process, and subsequent recovery of function in conditions such as amblyopia, can now be studied with realistic circuit models that might generalize across systems...
  13. ncbi GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1
    Stanislav Khirug
    Department of Biological and Environmental Sciences, University of Helsinki, FIN 00014 Helsinki, Finland
    J Neurosci 28:4635-9. 2008
    ..Our findings demonstrate that spatially distinct interneuronal inputs can induce postsynaptic voltage responses with different amplitudes and polarities as governed by the subcellular distributions of plasmalemmal chloride transporters...
  14. ncbi Development of GABA innervation in the cerebral and cerebellar cortices
    Z J Huang
    Cold Spring Harbour Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Rev Neurosci 8:673-86. 2007
    ..The cellular and molecular mechanisms that specify and modify inhibitory innervation patterns are only just beginning to be understood...
  15. ncbi Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
    Vivien Chevaleyre
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 38:461-72. 2003
    ..This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory...
  16. ncbi Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial
    M Backonja
    Department of Neurology, University of Wisconsin, Madison 53792, USA
    JAMA 280:1831-6. 1998
    ..Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus develop peripheral neuropathies...
  17. ncbi Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale
    J T Farrar
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Blockley Hall, Room 816, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Pain 94:149-58. 2001
    ..Use of a standard outcome across chronic pain studies would greatly enhance the comparability, validity, and clinical applicability of these studies...
  18. pmc The endocannabinoid system controls key epileptogenic circuits in the hippocampus
    Krisztina Monory
    Department of Physiological Chemistry, Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Neuron 51:455-66. 2006
    ..The direct endocannabinoid-mediated control of hippocampal glutamatergic neurotransmission may constitute a promising therapeutic target for the treatment of disorders associated with excessive excitatory neuronal activity...
  19. ncbi Genes required for GABA function in Caenorhabditis elegans
    S L McIntire
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Nature 364:334-7. 1993
    ..Some of these genes are likely to encode previously unidentified proteins required for GABA function...
  20. ncbi Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn
    Stacey M Glasgow
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 132:5461-9. 2005
    ..5. Thus, Ptf1a function is essential for GABAergic over glutamatergic neuronal cell fates in the developing spinal cord, and provides an important genetic link between inhibitory and excitatory interneuron development...
  21. ncbi Interneuron migration from basal forebrain to neocortex: dependence on Dlx genes
    S A Anderson
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, CA 94143 0984, USA
    Science 278:474-6. 1997
    ..Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex...
  22. ncbi Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex
    Martine Hamann
    Department of Physiology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Neuron 33:625-33. 2002
    ..Tonic and spillover inhibition reduce the fraction of granule cells activated by mossy fiber input, generating an increase of coding sparseness, which is predicted to improve the information storage capacity of the cerebellum...
  23. pmc Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning
    Peer Wulff
    Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK
    Nat Neurosci 12:1042-9. 2009
    ....
  24. ncbi Role of inhibition for temporal and spatial odor representation in olfactory output neurons: a calcium imaging study
    Silke Sachse
    Institut für Biologie Neurobiologie, Freie Universitat Berlin, Königin Luise Strasse 28 30, D 14195 Berlin, Germany
    J Neurophysiol 87:1106-17. 2002
    ..Selectively inhibited glomeruli need not be spatial neighbors. The net result is a globally modulated, contrast-enhanced and predictable representation of odors in the olfactory output neurons...
  25. pmc GABA regulates synaptic integration of newly generated neurons in the adult brain
    Shaoyu Ge
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 439:589-93. 2006
    ....
  26. ncbi Local-circuit neurones in the medial prefrontal cortex (areas 25, 32 and 24b) in the rat: morphology and quantitative distribution
    P L Gabbott
    University Department of Pharmacology, Oxford, England
    J Comp Neurol 377:465-99. 1997
    ..The data provide the structural basis for a qualitative and quantitative definition of local cortical circuits in the rat mPFC...
  27. ncbi Mitochondrial transport proteins of the brain
    D A Berkich
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Neurosci Res 85:3367-77. 2007
    ....
  28. ncbi Expression and function of SNAP-25 as a universal SNARE component in GABAergic neurons
    Lawrence C R Tafoya
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Neurosci 26:7826-38. 2006
    ....
  29. ncbi Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish
    S C Martin
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston University Medical Center Hospital, Massachusetts 02118, USA
    J Comp Neurol 396:253-66. 1998
    ..The zebrafish GAD65 and GAD67 are present in identified neurons in the forebrain, midbrain, hindbrain, and spinal cord, and they catalyze the production of GABA in the developing embryo...
  30. pmc DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains
    M Veldic
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 101:348-53. 2004
    ....
  31. ncbi Ambient GABA promotes cortical entry of tangentially migrating cells derived from the medial ganglionic eminence
    Verginia C Cuzon
    Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cereb Cortex 16:1377-88. 2006
    ..Treatment with diazepam or addition of exogenous GABA increased crossing index. We conclude that ambient GABA promotes cortical entry of tangentially migrating MGE-derived cells...
  32. pmc Neurofibromin regulation of ERK signaling modulates GABA release and learning
    Yijun Cui
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 135:549-60. 2008
    ..Importantly, our results also revealed lasting increases in GABA release triggered by learning, indicating that the mechanisms uncovered here are of general importance for learning...
  33. ncbi Regulation of excitability by extrasynaptic GABA(A) receptors
    Matthew C Walker
    Institute of Neurology, University College London, Queen Square, London, UK
    Results Probl Cell Differ 44:29-48. 2008
    ..Therefore, drugs specifically aimed at targeting the extrasynaptic receptors involved in tonic inhibition could be a novel approach to regulating both physiological and pathological processes...
  34. pmc GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation
    Doris D Wang
    Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 28:5547-58. 2008
    ..Our study identifies an essential role for GABA in the synaptic integration of newborn cortical neurons and suggests an activity-dependent mechanism for achieving the balance between excitation and inhibition in the developing cortex...
  35. ncbi Cation-chloride co-transporters in neuronal communication, development and trauma
    John A Payne
    Department of Human Physiology, School of Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Trends Neurosci 26:199-206. 2003
    ....
  36. pmc Cl- uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1
    Junko Yamada
    Department of Biological Information Processing, Graduate School of Electronic Science and Technology, Shizuoka University, Hamamatsu, Shizuoka 432 8011, Japan
    J Physiol 557:829-41. 2004
    ..These data suggest that NKCC1 may play a pivotal role in the generation of GABA-mediated depolarization in immature CP cells, while KCC2 promotes the later maturation of GABAergic inhibition in the rat neocortex...
  37. ncbi GABA, a forgotten gliotransmitter
    María Cecilia Angulo
    INSERM U603, Paris, France CNRS UMR 8154, Paris, France Université Paris Descartes, Paris, France
    Prog Neurobiol 86:297-303. 2008
    ..We then review the results of recent experiments that point toward functional roles of GABA as a "gliotransmitter"...
  38. ncbi Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity
    G P Reynolds
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Brain Res Bull 55:579-84. 2001
    ..In this review we discuss the evidence for altered GABAergic transmission in schizophrenia...
  39. ncbi The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain
    S Abdi
    Department of Anesthesiology and Critical Care, The Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Anesth Analg 87:1360-6. 1998
    ..Finally, the site of action of LDC seems to be primarily in the periphery, and that of GBP is exclusively central, whereas that of AMI seems to have both peripheral and central components...
  40. ncbi Cellular and molecular action of the putative GABA-mimetic, gabapentin
    Y P Maneuf
    Cambridge Biotechnology Ltd, PO Box 230, Cambridge CB2 1XJ, United Kingdom
    Cell Mol Life Sci 60:742-50. 2003
    ....
  41. ncbi Evidence that certain retinal bipolar cells use both glutamate and GABA
    Yen Hong Kao
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    J Comp Neurol 478:207-18. 2004
    ..By "targeted injection," we identified two types of OFF bipolar cell with the machinery to make and package both transmitters. One of these types costratifies with a dopamine plexus...
  42. ncbi Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala
    Daniel Huber
    Department of Cellular Biology and Morphology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland
    Science 308:245-8. 2005
    ..Through this network, the expression and endogenous activation of vasopressin and oxytocin receptors may regulate the autonomic expression of fear...
  43. pmc GABA(B) receptor modulation of feedforward inhibition through hippocampal neurogliaform cells
    Christopher J Price
    Medical Research Council Anatomical Neuropharmacology Unit, Oxford OX1 3TH, United Kingdom
    J Neurosci 28:6974-82. 2008
    ..The NGFC-CA1 pyramidal cell connection therefore provides a unique and subtle mechanism to shape the integration time domain for signals arriving via a major excitatory input to CA1 pyramidal cells...
  44. ncbi Spike transmission and synchrony detection in networks of GABAergic interneurons
    M Galarreta
    Department of Comparative Medicine, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 292:2295-9. 2001
    ..These results indicate that networks of fast-spiking cells may play a role in the detection and promotion of synchronous activity within the neocortex...
  45. pmc Glutamatergic neurons are present in the rat ventral tegmental area
    Tsuyoshi Yamaguchi
    National Institute on Drug Abuse, Cellular Neurophysiology, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 25:106-18. 2007
    ..Based on the results described here, we concluded that the VTA contains glutamatergic neurons that in their vast majority are clearly non-DAergic and non-GABAergic...
  46. ncbi GABAergic nature of hypothalamic leptin target neurones in the ventromedial arcuate nucleus
    M L Ovesjö
    Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Neuroendocrinol 13:505-16. 2001
    ..However, mechanisms other than transcriptional regulation for leptin to influence arcuate GABA neurones may exist...
  47. pmc GABA B receptor is a novel drug target for pancreatic cancer
    Hildegard M Schuller
    Experimental Oncology Laboratory, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Cancer 112:767-78. 2008
    ..The aim of the study was to investigate if GABA B R inhibits beta-AR signaling in PDAC and pancreatic duct epithelial cells, thus blocking driving forces of cancer progression, such as cell proliferation and cell migration...
  48. pmc Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors
    U Gunther
    Institute of Pharmacology, University of Zurich, Switzerland
    Proc Natl Acad Sci U S A 92:7749-53. 1995
    ..The lack of postnatal GABAA receptor regulation by endogenous ligands of BZ sites might contribute to this phenotype...
  49. ncbi GABA plasma membrane transporters, GAT-1 and GAT-3, display different distributions in the rat hippocampus
    C E Ribak
    Department of Anatomy and Neurobiology, University of California, Irvine 92717, USA
    J Comp Neurol 367:595-606. 1996
    ..This localization of GAT-1 and GAT-3 indicates that they are involved in the uptake of GABA from the extracellular space into GABAergic axon terminals and astrocytes...
  50. ncbi Roles of inhibition for transforming binaural properties in the brainstem auditory system
    George D Pollak
    Section of Neurobiology, The University of Texas at Austin, Austin, TX 78731, USA
    Hear Res 168:60-78. 2002
    ....
  51. ncbi Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain
    M Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 75:732-40. 2000
    ..The results further suggest a psychological role for neurosteroids and GABA(A) receptors in the modulation of emotional behavior and mood...
  52. ncbi Molecular and functional diversity of the expanding GABA-A receptor gene family
    P J Whiting
    Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, England, UK
    Ann N Y Acad Sci 868:645-53. 1999
    ..The structure, function, and distribution of theta-containing receptors, and receptors containing the recently reported epsilon subunit, are described...
  53. pmc Norepinephrine enables the induction of associative long-term potentiation at thalamo-amygdala synapses
    Keith Tully
    Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 104:14146-50. 2007
    ..Thus, adrenergic modulation of local interneurons may contribute to the formation of fear memory by gating LTP in the conditioned stimulus pathways...
  54. ncbi Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions
    Chi Sung Chiu
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 22:10251-66. 2002
    ..Knock-in mice carrying GFP fusions of membrane proteins provide quantitative data required for understanding the details of synaptic transmission in living neurons...
  55. ncbi Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells
    Anna Wendt
    Department of Physiological Sciences, Lund University, Lund, Sweden
    Diabetes 53:1038-45. 2004
    ..This effect was not observed in the presence of SR95531, and we therefore conclude that isradipine stimulates glucagon secretion by inhibition of GABA release...
  56. ncbi The endogenous cannabinoid system controls extinction of aversive memories
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Nature 418:530-4. 2002
    ..We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala...
  57. ncbi GABA signaling: a conserved and ubiquitous mechanism
    Nicolas Bouche
    Commissariat a l Energie Atomique, Direction des Sciences du Vivant, Service de Bioenergetique, 91191, Gif sur Yvette, France
    Trends Cell Biol 13:607-10. 2003
    ..Here, we discuss recent findings that point towards a possible role for GABA as a signaling molecule in plants...
  58. ncbi GABAergic neuronal subtypes in the human frontal cortex--development and deficits in schizophrenia
    G P Reynolds
    Department of Biomedical Science, The University of Sheffield, Western Bank, S10 2TN, Sheffield, UK
    J Chem Neuroanat 22:95-100. 2001
    ..These observations support the hypothesis that GABAergic deficits in schizophrenia may stem from toxic events occurring during cortical development which selectively target immature neurons before protection by parvalbumin is conferred...
  59. ncbi The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    C Rivera
    Department of Biosciences, University of Helsinki, Finland
    Nature 397:251-5. 1999
    ..These data support the conclusion that KCC2 is the main Cl- extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain...
  60. ncbi Inhibition of paclitaxel-induced A-fiber hypersensitization by gabapentin
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 318:735-40. 2006
    ....
  61. ncbi Depolarizing GABA acts on intrinsically bursting pyramidal neurons to drive giant depolarizing potentials in the immature hippocampus
    Sampsa T Sipilä
    Department of Biological and Environmental Sciences, University of Helsinki, FIN 00014 Helsinki, Finland
    J Neurosci 25:5280-9. 2005
    ....
  62. ncbi Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit
    Darrell M Porcello
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurophysiol 89:1378-86. 2003
    ..This suggests delta subunit containing GABA(A) receptors may be functionally limited to an extrasynaptic locus in VB neurons...
  63. ncbi Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
    Schahram Akbarian
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, 303 Belmont Street, Worcester, 01604, USA
    Brain Res Rev 52:293-304. 2006
    ..We propose an integrative model, with multiple molecular and cellular mechanisms contributing to transcriptional dysregulation of GAD67 and cortical dysfunction in psychosis...
  64. pmc Asymmetric redistribution of GABA receptors during GABA gradient sensing by nerve growth cones analyzed by single quantum dot imaging
    Cedric Bouzigues
    Laboratoire Kastler Brossel, Centre National de la Recherche Scientifique, Physics Department, Ecole Normale Superieure, and Université Pierre et Marie Curie Paris 6, 24, rue Lhomond, 75005 Paris, France
    Proc Natl Acad Sci U S A 104:11251-6. 2007
    ..Altogether, our results reveal a microtubule-dependent polarized reorganization of chemoreceptors at the cell surface and suggest that this polarization serves as an amplification step in GABA gradient sensing by nerve GCs...
  65. pmc Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells
    Matthias Braun
    Oxford Center for Diabetes, Endocrinology, and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
    J Gen Physiol 129:221-31. 2007
    ....
  66. ncbi Cloning and functional expression of GABA(B) receptors from Drosophila
    M Mezler
    Bayer AG, Agricultural Centre, Molecular Target Research, Geb 6240, Alfred Nobel Strasse 50, 40789 Monheim, Germany
    Eur J Neurosci 13:477-86. 2001
    ..The pharmacology of the coexpressed D-GABA(B)R1/2 receptor was different from the mammalian GABA(B)Rs: e.g. baclofen, an agonist of mammalian GABA(B)Rs, showed no effect...
  67. pmc Involvement of the amygdala in memory storage: interaction with other brain systems
    J L McGaugh
    Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697 3800, USA
    Proc Natl Acad Sci U S A 93:13508-14. 1996
    ..These findings provide strong evidence supporting the hypothesis that the amygdala is involved in modulating long-term memory storage...
  68. ncbi The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction
    Michael M Francis
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Neuron 46:581-94. 2005
    ..We hypothesize that CAM-1 contributes to the localization or stabilization of postsynaptic ACR-16 receptors and presynaptic release sites...
  69. ncbi Treatment of restless legs syndrome with gabapentin: a double-blind, cross-over study
    D Garcia-Borreguero
    Department of Neurology, Fundacion Jimenez Diaz, Madrid, Spain
    Neurology 59:1573-9. 2002
    ..To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS)...
  70. ncbi The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin
    Claudia S Bauer
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 29:4076-88. 2009
    ....
  71. ncbi Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6
    Vassiliki Nikoletopoulou
    Biozentrum, University of Basel, 4056 Basel, Switzerland
    Cell Stem Cell 1:529-40. 2007
    ..They also provide a novel opportunity to compare the molecular constituents of glutamatergic with those of GABA-ergic neurons and to explore the mechanisms of their generation...
  72. ncbi Synaptic signaling between GABAergic interneurons and oligodendrocyte precursor cells in the hippocampus
    Shih Chun Lin
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe Street, WBSB 813, Baltimore, Maryland 21205, USA
    Nat Neurosci 7:24-32. 2004
    ....
  73. ncbi Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain
    E Polgar
    Spinal Cord Group, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Pain 104:229-39. 2003
    ..Our results suggest that significant loss of GABAergic or glycinergic neurons is not necessary for the development of thermal hyperalgesia in the CCI model of neuropathic pain...
  74. ncbi International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function
    N G Bowery
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston, United Kingdom
    Pharmacol Rev 54:247-64. 2002
    ..The advent of GABA(B1) knockout mice has also failed to provide support for multiple receptor types...
  75. ncbi Differential abilities of SNAP-25 homologs to support neuronal function
    Ignacio Delgado-Martinez
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    J Neurosci 27:9380-91. 2007
    ..These data demonstrate a differential ability of SNAP-25b, SNAP-25a, and SNAP-23 to support neuronal function...
  76. ncbi Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1
    Petra Scholze
    Institute of Pharmacology, University of Vienna, Währinger Strasse 13a, Austria
    J Biol Chem 277:43682-90. 2002
    ..Hence, our findings strongly argue for a role of oligomer formation during biosynthesis and subsequent delivery of the multimer from the endoplasmic reticulum to the plasma membrane...
  77. ncbi Origin of GABAergic neurons in the human neocortex
    Kresimir Letinic
    Yale University School of Medicine, Section of Neurobiology, New Haven, Connecticut 06510, USA
    Nature 417:645-9. 2002
    ....
  78. ncbi Characterization of the circuits that generate spontaneous episodes of activity in the early embryonic mouse spinal cord
    M Gartz Hanson
    Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106 4975, USA
    J Neurosci 23:587-600. 2003
    ....
  79. ncbi Synaptic organization of the mushroom body calyx in Drosophila melanogaster
    Kouji Yasuyama
    Neuroscience Institute, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    J Comp Neurol 445:211-26. 2002
    ..The cholinergic boutons are the largest identified cholinergic synapses in the Drosophila brain and an eligible prospect for studying the genetic regulation of excitatory presynaptic function...
  80. ncbi A putative flip-flop switch for control of REM sleep
    Jun Lu
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 441:589-94. 2006
    ..The mutually inhibitory interactions of the REM-on and REM-off areas may form a flip-flop switch that sharpens state transitions and makes them vulnerable to sudden, unwanted transitions-for example, in narcolepsy...
  81. ncbi The role of early lineage in GABAergic and glutamatergic cell fate determination in Xenopus laevis
    Mei Li
    Department of Biology, College of William and Mary, Williamsburg, Virginia 23187, USA
    J Comp Neurol 495:645-57. 2006
    ..In addition, the fate map presented here suggests a general dorsal-anterior to ventral-posterior patterning progression of the nervous system for the 32-cell stage Xenopus embryo...
  82. ncbi When inhibition goes incognito: feedback interaction between spiny projection neurons in striatal function
    Dietmar Plenz
    Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda 20892, USA
    Trends Neurosci 26:436-43. 2003
    ..They have also suggested new experimental directives for examining the specific ways in which spiny projection neurons both compete and cooperate through their local axon collaterals during cortical input processing...
  83. pmc Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina
    Liang Feng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Development 133:4815-25. 2006
    ..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
  84. ncbi GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat
    Jozsef Somogyi
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Oxford OX1 3TH, UK
    Eur J Neurosci 19:552-69. 2004
    ..The presumed amino acid substrate of VGLUT3 may act on presynaptic kainate or group II metabotropic glutamate receptors...
  85. ncbi Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials
    Miroslav Backonja
    Department of Neurology, Anesthesiology, and Rehabilitation Medicine, University of Wisconsin Hospital and Clinics, Madison, Wisconsin 53792, USA
    Clin Ther 25:81-104. 2003
    ..Tricyclic antidepressants are considered first-line agents for neuropathic pain, but their use is limited by unwanted side effects and a risk of cardiovascular mortality...
  86. ncbi Gabapentin in neuropathic pain syndromes: a randomised, double-blind, placebo-controlled trial
    M G Serpell
    University Department of Anaesthesia and Pain Management, Gartnavel General Hospital, 30 Shelly Court, G12 0YN, Scotland, Glasgow, UK
    Pain 99:557-66. 2002
    ..This study shows that gabapentin reduces pain and improves some quality-of-life measures in patients with a wide range of neuropathic pain syndromes...
  87. ncbi Increased GABA release in the central amygdala of ethanol-dependent rats
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:10159-66. 2004
    ..These combined findings suggest that acute and chronic ethanol increases GABA release in CeA and support previous reports that the behavioral actions of ethanol are mediated, in part, by increased GABAergic transmission in the CeA...
  88. ncbi Identification and characterization of the vesicular GABA transporter
    S L McIntire
    Graduate Programs in Neuroscience, Cell Biology and Biomedical Sciences, Department of Neurology, UCSF School of Medicine, San Francisco, California 94143 0435, USA
    Nature 389:870-6. 1997
    ..Thus VGAT is the first of a new family of neurotransmitter transporters...
  89. ncbi CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
    Science 302:84-8. 2003
    ..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
  90. ncbi The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia
    David Cotter
    Department of Psychological Medicine, Section of Experimental Neuropathology and PsychiatryInstitute of Psychiatry, London, United Kingdom
    Biol Psychiatry 51:377-86. 2002
    There is strong evidence for the presence of a deficit in cortical gamma aminobutyric acid (GABA) neurotransmission in schizophrenia...
  91. ncbi Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength
    Gregory C Mathews
    Synaptic Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4066, USA
    J Neurosci 23:2040-8. 2003
    ..This modulation appears to occur under normal conditions and may constitute a negative feedback mechanism to combat hyperexcitability...
  92. ncbi Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia
    Hanne Gottrup
    Danish Pain Research Center, Department of Neurology and Danish Pain Research Center, University of Aarhus
    Anesthesiology 101:1400-8. 2004
    ..The aims were to determine whether gabapentin, dosed in a manner similar to that used in the clinic, affected the various components of central sensitization and to assess the utility of this model for characterizing novel analgesics...
  93. pmc A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy
    Jehuda P Sepkuty
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287 7247, USA
    J Neurosci 22:6372-9. 2002
    ..EAAC1 may participate in normal GABA neurosynthesis and limbic hyperexcitability, whereas epilepsy can result from a disruption of the interaction between EAAC1 and GABA metabolism...
  94. ncbi SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization
    Claudia Verderio
    Department of Medical Pharmacology, CNR Institute of Neuroscience, Center of Excellence for Neurodegenerative Diseases, University of Milano, Via Vanvitelli 32, Milano 20129, Italy
    Neuron 41:599-610. 2004
    ..SNAP-25 is therefore a multifunctional protein that participates in exocytotic function both at the mechanistic and at the regulatory level...
  95. ncbi Excitatory effects of GABA in established brain networks
    Alain Marty
    Laboratoire de Physiologie Cérébrale, Université Paris 5 CNRS, 45 Rue des Saints Peres, 75006 Paris, France
    Trends Neurosci 28:284-9. 2005
    ..Evidence reviewed here indicates that, contrary to common belief, these effects are not restricted to embryonic or neonatal preparations...
  96. ncbi GABAA receptor-mediated tonic inhibition in thalamic neurons
    David W Cope
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    J Neurosci 25:11553-63. 2005
    ..Thus, tonic current in TC neurons generates an inhibitory tone. Its modulation contributes to the shift between different firing modes, promotes the transition between different behavioral states, and predisposes to absence seizures...
  97. ncbi Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus
    Shinji Muroya
    Department of Physiology, Division of Integrative Physiology, Jichi Medical School, Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Eur J Neurosci 19:1524-34. 2004
    ..Orexin-A evokes Ca(2+) signaling in NPY neurons via OX(1)R-PLC-PKC and IP(3) pathways. These neural pathways and intracellular signaling mechanisms may play key roles in the orexigenic action of orexins...
  98. ncbi GABA action in immature neocortical neurons directly depends on the availability of ketone bodies
    Sylvain Rheims
    INMED INSERM U901, Universite de la Mediterranee, Marseille, France
    J Neurochem 110:1330-8. 2009
    ..Therefore, by inducing a hyperpolarizing shift in E(m) and modulating GABA signaling mode, KBs can efficiently control the excitability of neonatal cortical neurons...
  99. ncbi Expression profiling of GABAergic motor neurons in Caenorhabditis elegans
    Hulusi Cinar
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064 USA
    Curr Biol 15:340-6. 2005
    ..Behavioral studies of a deletion mutant implicate a function of a nicotinic receptor subunit in D-type neurons. Our analysis demonstrates the utility of neuron-specific genomics in identifying cell-specific genes and regulatory networks...
  100. ncbi Abnormal GABAA receptor-mediated currents in dorsal root ganglion neurons isolated from Na-K-2Cl cotransporter null mice
    K W Sung
    Departments of Anesthesiology, Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennesse, USA
    J Neurosci 20:7531-8. 2000
    ....
  101. ncbi Neuronal-glial glucose oxidation and glutamatergic-GABAergic function
    Fahmeed Hyder
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cereb Blood Flow Metab 26:865-77. 2006
    ..The relationship observed between DeltaCMR(glc(ox), N) and DeltaV(cyc(tot)) is determined by glial glycolytic ATP as before. Quantitative aspects of the model, which can be tested by experimentation, are discussed...

Research Grants64

  1. Modulation of cancer prevention by social stress
    Hildegard M Schuller; Fiscal Year: 2010
    ....
  2. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..regulating brain-derived nerve growth factor (BDNF;associated with MOD) and its interactions with gamma aminobutyric acid (GABA)-ergic, glutamate (GLU)-tamatergic and nitric oxide (NO) mechanisms in development of key brain ..
  3. Neuroendocrine Contribution to Behavior &Cognition in the Female Lifespan
    C NEILL NEILL EPPERSON; Fiscal Year: 2013
    ..abstract_text> ..
  4. Pharmacological Management of Delirium
    Malaz Boustani; Fiscal Year: 2013
    ..The primary outcomes of the study are delirium severity, as measured by the Delirium Rating Scale (DRS-R-98);and delirium duration as measured by the Confusion Assessment Method in the ICU (CAM-ICU). ..
  5. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher L Cunningham; Fiscal Year: 2012
    ..These studies could prove to be especially useful in the future evaluation of putative pharmacotherapies to reduce craving and in the design of behavioral interventions (e.g., cue-exposure therapy) to decrease ethanol-seeking behavior. ..
  6. Structural Rearrangements in GABA-A Receptors
    CYNTHIA M CZAJKOWSKI; Fiscal Year: 2012
    ....
  7. General Anesthetic Sites in GABA-A Receptor Subunit Interfacial Pockets
    Stuart A Forman; Fiscal Year: 2013
    ....
  8. GABA-A Receptor Pharmacology of Neural Coding in Hippocampal Place Cells
    TARA MONIQUE STEWART; Fiscal Year: 2012
    ..abstract_text> ..
  9. Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe Sepsis
    Pratik Pandharipande; Fiscal Year: 2013
    ..5 delirium/coma-free days and an absolute difference in mortality of 10% between the two groups. ..
  10. Glutamate, aging and enriched environment after dopamine loss
    CHARLES KENNETH MESHUL; Fiscal Year: 2013
    ....
  11. Efficacy &safety of baclofen to reduce alcohol use in veterans with HCV
    Peter Hauser; Fiscal Year: 2013
    ..Therefore this study's relevance lies not only in its potential to reduce alcohol use and the consequent accelerated liver damage but also in allowing more HCV patients to participate in antiviral therapy. ..
  12. The Antidepressant Action of Ketamine:Brain Chemistry
    MATE ISTVAN MILAK; Fiscal Year: 2013
    ..acute increase (more than 60%) in glutamate (Glu;the endogenous agonist of NMDA and AMPA receptors) and gamma aminobutyric acid (GABA) levels in the anterior cingulate cortex (ACC) as measured by proton magnetic resonance ..
  13. The Role of Amygdala GABAergic Transmission in Fear and Anxiety
    Scott A Heldt; Fiscal Year: 2011
    ..We hypothesize that associated changes in amygdala GABAergic function will result in blunted anxiety-like behavioral effects to BZ. ..
  14. The Functional Maturation of Inhibitory Interneurons
    MATTHEW LAZARUS; Fiscal Year: 2010
    ....
  15. Assessing GABAergic Involvement in Schizophrenia-Like Cognitive Deficits in Rats
    Mark Renato Stefani; Fiscal Year: 2012
    ....
  16. Cortical GABA in MDD and Primary Insomnia with Magnetic Resonance Spectroscopy
    John W Winkelman; Fiscal Year: 2013
    ..We will also use regression analysis to correlate PSG and sleep diary information, with 1H-MRS-derived GABA data. ..
  17. GABA-A alpha5 cognitive enhancers: pharmacology and neuropsychology in macaques
    Nancy A Ator; Fiscal Year: 2011
    ....
  18. Neurosteroid Modulation of Extrasynaptic GABAA Receptors
    EYDITH JANICE COMENENCIA ORTIZ; Fiscal Year: 2012
    ..The studies in this application will provide insight into neurosteroid-mediated alterations in neuronal excitability an might contribute to the development of novel treatments for postpartum depression, epilepsy and anxiety disorders. ..
  19. The Regulation of GABAA Receptor Cell Surface Stability
    Stephen Moss; Fiscal Year: 2009
    ..abstract_text> ..
  20. Vulnerability to Drug Abuse and Treatment Efficacy: Animal Models
    Marilyn E Carroll; Fiscal Year: 2010
    ..Medications to be tested will be baclofen, a gamma aminobutyric acid B (GABAB) agonist that blocks many aspects of drug abuse, and progesterone which has been shown to reduce ..
  21. Regulation of voltage-gated calcium channels during chronic BZ treatment in rats
    DAMIEN EUGENE EARL; Fiscal Year: 2013
    ..Elucidation of this mechanism could reveal new therapeutic targets for BZ withdrawal, and possibly withdrawal from other drugs of abuse. ..
  22. Molecular Physiology of y-Aminobutyric Acid Transporters
    Sepehr Eskandari; Fiscal Year: 2012
    ..The proposed research examines the mechanism of function of GABA transporters and will pave the way for the development of novel isoform-specific antiepileptic drugs. ..
  23. Neurotransmitter Regulation of Glial Cytokine Expression
    BRYAN SPANGELO; Fiscal Year: 2009
    ..Understanding molecular mechanisms by which neurotransmitters can prevent such toxic glial activation will provide new strategies for pharmacological abrogation of glia-mediated neuronal injury. ..
  24. MR Imaging of the Excitatory and Inhibitory Neurotransmitters in Chronic Pain
    Bradley Foerster; Fiscal Year: 2013
    ....
  25. Preclinical Assessment of Medications for Alcohol Abuse
    Elise M Weerts; Fiscal Year: 2011
    ..abstract_text> ..
  26. Cerebral GABA and Fear Conditioning in PTSD
    Isabelle M Rosso; Fiscal Year: 2013
    ....
  27. Amino acid neurotransmitter sensors for MRI
    Alan Jasanoff; Fiscal Year: 2013
    ..In Aim 3, we will extend our glutamate sensor design strategy to target GABA, the dominant inhibitory neurotransmitter in the brain. The proposed research has ..
  28. Mechanisms of developmental sensitivity to nicotine withdrawal
    LUIS ALBERTO NATIVIDAD; Fiscal Year: 2010
    ..Collectively, these studies will provide a characterization of the mechanisms that mediate nicotine withdrawal at different stages of rodent development. ..
  29. Genetic Links to the Reinforcing Effects of Alcohol in a Social Context
    Kasey M Griffin; Fiscal Year: 2010
    ..This information will greatly inform theories of drinking and alcoholism and will help to predict who may be at risk of developing drinking problems. ..
  30. MRS Studies of Glutamate and GABA in Bipolar Dissorder
    Dost Ongur; Fiscal Year: 2011
    ..There is therefore a pressing need for effective novel treatments which target relevant biological processes in BD, and the current proposal aims to contribute to meeting this need. ..
  31. HYPOTHALAMIC CONTROL OF GONADOTROPIN SECRETION
    EI TERASAWAGRILLEY; Fiscal Year: 2011
    ..and LHRH neurosecretion, 2) the ability of estrogen to modify the responsiveness of LHRH neurons to gamma aminobutyric acid (GABA) and test 3) a novel hypothesis that the BK potassium channel mediates estrogen action...
  32. GABA-mediated connectivity in the preterm brain
    Laura R Ment; Fiscal Year: 2012
    ..b>Gamma aminobutyric acid (GABA) interneurons are central to the development of these networks, and preclinical data suggest that ..
  33. Role of receptor trafficking in synaptic plasticity during morphine dependence
    Anuradha Madhavan; Fiscal Year: 2013
    ..The results from these experiments are likely to yield interesting and novel insights on the induction of synaptic plasticity and the role of MOR endocytosis during development of morphine dependence. ..
  34. in Vivo Quantification of Cerebellar GABA and NAA in Essential Tremor
    Elan D Louis; Fiscal Year: 2013
    ..We expect that the proposed research will elucidate the underlying disease pathophysiology and provide useful diagnostic biomarkers as well as markers of disease progression for future neuroprotective trials. ..
  35. Inhibitory Controls in the Thalamic Reticular Nucleus
    John R Huguenard; Fiscal Year: 2010
    ..The results of these experiments will provide insight regarding therapeutic approaches that are likely to be effective in the treatment of generalized absence seizures. ..
  36. ETHANOL, NEUROSTEROIDS &HIPPOCAMPAL PLASTICITY
    Charles F Zorumski; Fiscal Year: 2013
    ..The long-term goal of these studies is to identify ways to protect the nervous system from the adverse effects of ethanol on synaptic function and cognition. ..
  37. Molecular mechanism for the synaptic localization of GABA(A)Rs.
    James Martenson; Fiscal Year: 2013
    ..Successful completion of this proposal will provide me not only with novel findings regarding GABAARs, but also various experimental techniques and knowledge, and thus is an ideal proposal for the F30 training program. ..
  38. DRUGS OF ABUSE AND HUMAN AGGRESSIVE BEHAVIOR
    Scott D Lane; Fiscal Year: 2010
    ..S. This phase our our research is looking at gamma aminobutyric acid (GABA) medications as potential interventions to decrease aggression as a venue which may influence ..
  39. ETHANOL EFFECT ON THE BASAL FOREBRAIN CORTEX SYSTEM
    Michael Miller; Fiscal Year: 1999
    ....
  40. Biobehavioral effects of topiramate on cannabis-related outcomes in adolescents
    Robert Miranda; Fiscal Year: 2010
    ..TPM facilitates gamma aminobutyric acid (GABA) neurotransmission and blocks AMPA/kainite glutamate receptors...
  41. GABAERGIC INSECTICIDE TOXICOLOGY
    JOHN CASIDA; Fiscal Year: 2002
    ....
  42. STUDIES OF NEURONAL AND GLIAL GLUTAMATE DECARBOXYLASES
    Jang Yen Wu; Fiscal Year: 1990
    ..We plan to use hybridoma technique which we have successfully developed for neuronal GAD to obtain monoclonal antibody to glial GAD...
  43. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
    ..abstract_text> ..
  44. GABAA RECEPTOR CHANNEL ALTERATION BY PROLONGED SEIZURES
    Robert MacDonald; Fiscal Year: 2003
    ....
  45. ANXIETY--GABA RECEPTOR AND OPIOID GENE TRANSFER
    MARLENE WILSON; Fiscal Year: 2000
    ..It will thus help to elucidate the role(s) of specific, localized neurotransmitter functions in complex behaviors such as anxiety. ..
  46. INACTIVATION AND STRUCTURE AND GABA AMINOTRANSFERASE
    Richard Silverman; Fiscal Year: 1999
    ....
  47. AGE RELATED SYNAPTIC CHANGES IN THE AUDITORY BRAINSTEM
    Robert Helfert; Fiscal Year: 1999
    ....
  48. SITES OF ANESTHETIC ACTION IN INHIBITORY RECEPTORS
    Eric Greenblatt; Fiscal Year: 2002
    ..These studies will provide insights into the molecular interaction of this group of Vas with specific neuronal components, which may facilitate the design of improved general anesthetics. ..
  49. NEUROCHEMICAL CORRELATES OF CEREBELLAR DEVELOPMENT
    Andrej Rotter; Fiscal Year: 1992
    ..In this hypothesis, the efferent input from Gabaergic neurons is not required for induction, stabilization of maintenance of GABA/BZ receptors...
  50. RESPIRATORY SYSTEM INTEGRATION BY THE BRAINSTEM
    ALBERT BERGER; Fiscal Year: 2002
    ..We hypothesize that ethanol increases the affinity of glycine-Rs for glycine and thereby potentiates inhibitory synaptic events. This may be an important mechanism whereby alcohol consumption exacerbates obstructive sleep apnea. ..
  51. Effects of acupuncture on chemotherapy-induced pain
    Ruixin Zhang; Fiscal Year: 2009
    ..This study will evaluate the effects and mechanisms of electroacupuncture (EA) on such pain in a rat model. The success of the proposed study will greatly advance the management of CIP. ..
  52. BENZODIAZEPINES AND THE GABA A RECEPTOR
    JOSEPH NEALE; Fiscal Year: 1999
    ....
  53. Neurobiological Foundations of reading (dis)ability
    Kenneth R Pugh; Fiscal Year: 2010
    ....
  54. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2005
    ..The proposed experiments will lead to new insights into the co-ordinate regulation of GABAergic neuron differentiation during fetal development. ..
  55. GABA Agonists as Pharmacotherapies for Cocaine Abuse
    CRAIG RUSH; Fiscal Year: 2003
    ..Finally, the proposed research will allow us to conduct retrospective analyses to determine the influence of individual differences (e.g., gender, other drug use) on the reinforcing and subjective effects of cocaine. ..
  56. REGULATION OF GAD PROTEIN LEVELS AND GENE EXPRESSION
    Karin Rimvall; Fiscal Year: 1993
    ..It has been reported that estradiol decrease GAD67 mRNA levels in the brain and it is well-known that estradiol act at the level of nuclear DNA to regulate gene expression...
  57. ROLE OF GABAERGIC NEURONS IN AUTONOMIC NUCLEI
    BANG HWANG; Fiscal Year: 1991
    b>Gamma aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the brain...
  58. CHEMICAL REACTIONS IN TRANSMISSION OF NERVE IMPULSES
    George Hess; Fiscal Year: 2004
    ..The ligands are isolated by a technique developed by the principal investigator's laboratory. ..
  59. EXPRESSION OF GRANULE CELL GABA RECEPTORS
    Adrienne Frostholm; Fiscal Year: 1993
    ..This work will lead to a fundamental understanding of GABAA receptor regulation by cellular interactions...
  60. Mechanism-Based & Structure-Based Inhibitors of GABA-AT
    Richard Silverman; Fiscal Year: 2007
    ..The driving force of the proposal is the design of novel inactivators, the elucidation of inactivation mechanisms, and the design of new potent inhibitors. ..
  61. Novel Pharmacotherapy for Dual Dependence
    Bankole Johnson; Fiscal Year: 2009
    ..Our objectives support NIH's mission to understand the basic mechanisms that underpin substance dependence, and to develop efficacious treatments for individuals with comorbid cocaine and alcohol dependence. ..
  62. ADENOVIRUS MEDIATED NEURONAL GABA RECEPTOR ENGINEERING
    Jay Yang; Fiscal Year: 1999
    ..In future proposals, the receptor engineering methods pioneered here will be applied to whole animal somatic cell gene-therapy for pathology ascribable to the GABAR malfunction such as epilepsy. ..
  63. Mapping the Putative Ethanol Binding Site on alpha4-beta2-delta GABA(A) Receptors
    KELLY CHRISTOPHERSON; Fiscal Year: 2009
    ..Alcohol affects the brain by binding to specific proteins called GABA (A) receptors. The proposed research will help identify where alcohol is binding to these receptors and thus will aid in the development of new drugs. ..
  64. Direct Interaction Between GABA-A and GABA-B Receptors
    Randy Hall; Fiscal Year: 2007
    ..abstract_text> ..