aspartic acid

Summary

Summary: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.

Top Publications

  1. pmc N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology
    John R Moffett
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Building C, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Prog Neurobiol 81:89-131. 2007
  2. pmc Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii
    Renae M Ryan
    Membrane Transport Biophysics Unit, Porter Neuroscience Center, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:17540-8. 2009
  3. pmc MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA
    Jianmin Meng
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 285:27935-43. 2010
  4. ncbi Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter
    Olga Boudker
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, New York 10032, USA
    Nature 445:387-93. 2007
  5. pmc Age-related change in brain metabolite abnormalities in autism: a meta-analysis of proton magnetic resonance spectroscopy studies
    Y Aoki
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Transl Psychiatry 2:e69. 2012
  6. ncbi Na(+):aspartate coupling stoichiometry in the glutamate transporter homologue Glt(Ph)
    Maarten Groeneveld
    Department of Biochemistry, University of Groningen, Groningen Biomolecular Science and Biotechnology Institute, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Biochemistry 49:3511-3. 2010
  7. ncbi Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis
    C E Teunissen
    Molecular Cell Biology and Immunology, VU University Medical Center, FdG, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 72:1322-9. 2009
  8. ncbi DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters
    K Shimamoto
    Suntory Institute for Bioorganic Research, Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618, Japan
    Mol Pharmacol 53:195-201. 1998
  9. ncbi Paxillin associates with the microtubule cytoskeleton and the immunological synapse of CTL through its leucine-aspartic acid domains and contributes to microtubule organizing center reorientation
    Leslie K Robertson
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton T6G 2S2, Alberta, Canada
    J Immunol 187:5824-33. 2011
  10. pmc SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776
    Lisa Duvick
    Institute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuron 67:929-35. 2010

Research Grants

Detail Information

Publications344 found, 100 shown here

  1. pmc N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology
    John R Moffett
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Building C, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Prog Neurobiol 81:89-131. 2007
    ..Further research will be required to more fully understand the biochemical functions served by NAA in CNS development and activity, and additional functions are likely to be discovered...
  2. pmc Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii
    Renae M Ryan
    Membrane Transport Biophysics Unit, Porter Neuroscience Center, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 284:17540-8. 2009
    ..We propose a kinetic model of transport in which at least two Na+ ions are coupled to the cotransport of each aspartate molecule by GltPh, and where an ion- and substrate-free transporter reorients to complete the transport cycle...
  3. pmc MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA
    Jianmin Meng
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 285:27935-43. 2010
    ..Thus, surface charge differences at the two MD-2/TLR4 interfaces determine the species-specific activation of lipid IV(A)...
  4. ncbi Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter
    Olga Boudker
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, New York 10032, USA
    Nature 445:387-93. 2007
    ....
  5. pmc Age-related change in brain metabolite abnormalities in autism: a meta-analysis of proton magnetic resonance spectroscopy studies
    Y Aoki
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Transl Psychiatry 2:e69. 2012
    ....
  6. ncbi Na(+):aspartate coupling stoichiometry in the glutamate transporter homologue Glt(Ph)
    Maarten Groeneveld
    Department of Biochemistry, University of Groningen, Groningen Biomolecular Science and Biotechnology Institute, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Biochemistry 49:3511-3. 2010
    ..Here we measure transport of (22)Na(+) and [(14)C]aspartate in proteoliposomes containing purified Glt(Ph) and demonstrate that three Na(+) ions are symported with aspartate...
  7. ncbi Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis
    C E Teunissen
    Molecular Cell Biology and Immunology, VU University Medical Center, FdG, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 72:1322-9. 2009
    ..Next, we wanted to know the additional value of measurement of NAA compared to other candidate markers for axonal damage, such as neurofilament subunits and tau protein...
  8. ncbi DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters
    K Shimamoto
    Suntory Institute for Bioorganic Research, Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618, Japan
    Mol Pharmacol 53:195-201. 1998
    ....
  9. ncbi Paxillin associates with the microtubule cytoskeleton and the immunological synapse of CTL through its leucine-aspartic acid domains and contributes to microtubule organizing center reorientation
    Leslie K Robertson
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton T6G 2S2, Alberta, Canada
    J Immunol 187:5824-33. 2011
    ..We mapped the region of paxillin that associates with both the MTOC and SMAC to the leucine-aspartic acid (LD) domains and showed that a protein segment containing LD2-4 was sufficient for MTOC and SMAC recruitment...
  10. pmc SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776
    Lisa Duvick
    Institute of Translational Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuron 67:929-35. 2010
    ..Ser776 is critical for the pathway to neuronal dysfunction, while an expanded polyglutamine tract is essential for neuronal death...
  11. ncbi In-vivo proton MR-spectroscopy of the human brain: assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration
    W Block
    Department of Radiology, University of Bonn, Bonn, Germany
    Amino Acids 23:317-23. 2002
    ..The observed regional metabolic alterations reflect the neuronal basis of the characteristic neurological symptoms in AD (dementia) and MND (muscular palsy) and mirrors the disease progress over time...
  12. pmc Neuraminidase receptor binding variants of human influenza A(H3N2) viruses resulting from substitution of aspartic acid 151 in the catalytic site: a role in virus attachment?
    Yi Pu Lin
    Virology Division, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    J Virol 84:6769-81. 2010
    ..not to be due to an antigenic change in hemagglutinin (HA) but was shown to be the result of a mutation in aspartic acid 151 of neuraminidase (NA) to glycine, asparagine, or alanine, which caused an oseltamivir-sensitive ..
  13. ncbi Proton magnetic resonance spectroscopy and illness stage in schizophrenia--a systematic review and meta-analysis
    Stefan Brugger
    Institute of Psychiatry, King s College London, London, United Kingdom
    Biol Psychiatry 69:495-503. 2011
    ....
  14. ncbi Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability
    N De Stefano
    Institute of Neurological Science, Viale Bracci 2, 53100, Siena, Italy
    Arch Neurol 58:65-70. 2001
    ..To assess axonal damage and its contribution to disability at different stages of multiple sclerosis (MS)...
  15. pmc 16S ribosomal RNA pseudouridine synthase RsuA of Escherichia coli: deletion, mutation of the conserved Asp102 residue, and sequence comparison among all other pseudouridine synthases
    J Conrad
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Florida 33101, USA
    RNA 5:751-63. 1999
    ..Aspartate102 is found in a conserved motif present in many pseudouridine synthases. The conservation and distribution of this motif in nature was assessed...
  16. pmc Aspartic acid racemization and collagen degradation markers reveal an accumulation of damage in tendon collagen that is enhanced with aging
    Chavaunne T Thorpe
    Division of Surgery and Interventional Science, University College London, Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, London, UK
    J Biol Chem 285:15674-81. 2010
    ..In this study, we have quantified the racemization of aspartic acid to calculate the age of the collagenous and non-collagenous components of the high strain injury-prone ..
  17. pmc Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors
    Mukesh K Agarwal
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 103:16278-83. 2006
    ..Stimulation of MIC-1-dependent S phase arrest in normal gut epithelial cells might help to revitalize the clinical use of PALA, which has been limited by gut toxicity...
  18. pmc Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter
    Shlomit Teichman
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Gen Physiol 129:527-39. 2007
    ....
  19. ncbi Proton magnetic resonance spectroscopy to evaluate spinal cord axonal injury in cervical spondylotic myelopathy
    Langston T Holly
    Departments of Neurosurgery, David Geffen School of Medicine at the University of California at Los Angeles, California 90095, USA
    J Neurosurg Spine 10:194-200. 2009
    ..The authors sought to determine the feasibility of using MR spectroscopy to analyze spinal cord biochemical function in patients with CSM...
  20. ncbi MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia
    Nuran Tunc-Skarka
    Department of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany
    Neuroimage 48:525-31. 2009
    ..Furthermore, they elucidate why reports of a reduced N-acetylaspartate concentration in schizophrenia were not always corroborated...
  21. pmc Universally applicable methods for monitoring response regulator aspartate phosphorylation both in vitro and in vivo using Phos-tag-based reagents
    Christopher M Barbieri
    Center for Advanced Biotechnology and Medicine, Department of Biochemistry and Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Anal Biochem 376:73-82. 2008
    ....
  22. pmc The handling of the mechanistic probe 5-fluorouridine by the pseudouridine synthase TruA and its consistency with the handling of the same probe by the pseudouridine synthases TruB and RluA
    Marguerite K McDonald
    Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA
    Biochemistry 50:426-36. 2011
    ..that the pseudouridine synthases proceed via a mechanism involving a Michael addition by an active site aspartic acid residue to the pyrimidine ring of uridine or F(5)U...
  23. ncbi Brainstem neurodegeneration correlates with clinical dysfunction in SCA1 but not in SCA2. A quantitative volumetric, diffusion and proton spectroscopy MR study
    L Guerrini
    Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, Viale Morgagni 85, Florence, Italy
    Brain 127:1785-95. 2004
    ....
  24. ncbi Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis
    R Grant Steen
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Neuropsychopharmacology 30:1949-62. 2005
    ..Only three of 64 studies included enough subjects to have 80% power to detect a 10% NAA reduction in patients, and no studies were adequately powered to detect a 5% NAA reduction with 80% power...
  25. pmc N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI)
    Jerzy Walecki
    Department of Radiology, Medical Centre of Postgraduate Education, Warsaw, Poland
    Med Sci Monit 17:MT105-11. 2011
    ..Purpose of study was evaluation of regional metabolic disorders using 1H MRS in patients with MCI, as a predictor of clinical conversion to dementia based on clinical follow-up...
  26. ncbi Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B
    Glen W Young
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 280:26094-8. 2005
    ..We therefore studied the D/L ratio of aspartic acid at specific sites in histone H2B, a known target of PIMT in vivo...
  27. ncbi The cell attachment site on foot-and-mouth disease virus includes the amino acid sequence RGD (arginine-glycine-aspartic acid)
    G Fox
    Wellcome Biotechnology Ltd, Pirbright, Surrey, U K
    J Gen Virol 70:625-37. 1989
    The amino acid sequence RGD (arginine-glycine-aspartic acid) is highly conserved in the VP1 protein of foot-and-mouth disease virus (FMDV), despite being situated in the immunodominant hypervariable region between amino acids 135 and 160...
  28. pmc Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients
    L L Chao
    Magnetic Resonance Unit, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, 116R, San Francisco, CA 94121, USA
    Neurology 64:282-9. 2005
    ..Because NAA is considered a marker of neuronal integrity, reduced medial temporal and parietal lobe NAA could be an early indication of dementia-related pathology in elderly individuals...
  29. ncbi Regional brain chemical alterations in young children with autism spectrum disorder
    S D Friedman
    Department of Radiology, University of Washington School of Medicine, Seattle 98105 6099, USA
    Neurology 60:100-7. 2003
    ..The authors evaluated regional brain chemistry for evidence of increased neuronal packing density in autism...
  30. pmc Endocytosis of the aspartic acid/glutamic acid transporter Dip5 is triggered by substrate-dependent recruitment of the Rsp5 ubiquitin ligase via the arrestin-like protein Aly2
    Riko Hatakeyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Mol Cell Biol 30:5598-607. 2010
    ..which are poorly characterized members of the arrestin-like protein family, mediate endocytosis of the aspartic acid/glutamic acid transporter Dip5...
  31. ncbi Metabolite concentrations in supraventricular white matter from teenage to early old age: A short echo time 1H magnetic resonance spectroscopy (MRS) study
    Raili Raininko
    Departments of Radiology, Uppsala University, Uppsala, Sweden
    Acta Radiol 51:309-15. 2010
    ..A long repetition time and short echo time technique reduces quantification errors due to T(1) and T(2) relaxation effects and makes it possible to measure metabolites with short T(2) relaxation times...
  32. ncbi Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy
    Angela Merkl
    Department of Psychiatry Charité Universitätsmedizin, Campus Benjamin Franklin, Berlin, Germany
    Biol Psychiatry 69:772-9. 2011
    ....
  33. ncbi Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas
    Tracy R McKnight
    Department of Radiology, University of California, San Francisco 94107, USA
    J Neurosurg 106:660-6. 2007
    ....
  34. ncbi Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders
    Taro Endo
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Science, Niigata City, Niigata, Japan
    Biol Psychiatry 62:1030-7. 2007
    ..The objective of the present study was to determine whether individuals with ASD have altered brain chemical metabolites and whether such alterations are related to their autistic symptoms...
  35. pmc Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits
    Varan Govind
    Department of Radiology, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurotrauma 27:483-96. 2010
    ..These results demonstrate that significant and widespread alterations of brain metabolites occur as a result of mild-to-moderate TBI, and that these measures correlate with measures of cognitive performance...
  36. ncbi The exceptionally tight affinity of DnaA for ATP/ADP requires a unique aspartic acid residue in the AAA+ sensor 1 motif
    Hironori Kawakami
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Microbiol 62:1310-24. 2006
    ..As the intrinsic ATPase activity of DnaA is extremely weak, this study reveals a novel and specific function for the sensor 1 motif in tight ATP/ADP binding, one that depends on the alternate key residue Asp...
  37. pmc Sequence diversities of serine-aspartate repeat genes among Staphylococcus aureus isolates from different hosts presumably by horizontal gene transfer
    Huping Xue
    Department of Animal Science, McGill University, Montreal, Quebec, Canada
    PLoS ONE 6:e20332. 2011
    ..In this study, the Serine-Aspartate Repeat (Sdr) family has been compared among different sources of Staphylococcus aureus (S. aureus) to discover sequence diversities within their genomes...
  38. pmc N-acetyl aspartate in autism spectrum disorders: regional effects and relationship to fMRI activation
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
    Brain Res 1162:85-97. 2007
    ..Furthermore, this study provided the first direct evidence of the relationship between abnormal functional activation in prefrontal cortex and neuronal dysfunction in ASD...
  39. ncbi 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders
    Lidia Gabis
    Weinberg Child Development Center, Safra Children s Hospital, Tel Hashomer, Israel
    J Child Neurol 23:766-74. 2008
    ..Magnetic resonance spectroscopy can provide important information regarding abnormal brain metabolism and clinical classification in autism spectrum disorders...
  40. pmc 1H-MRS at 4 tesla in minimally treated early schizophrenia
    J R Bustillo
    Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Mol Psychiatry 15:629-36. 2010
    ..We conclude that early in the illness, schizophrenia patients already show abnormalities in glutamatergic metabolism and reductions in NAA consistent with glutamate-related excitotoxicity...
  41. pmc Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1
    Zhen Tao
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    J Biol Chem 281:10263-72. 2006
    ..Here, we have investigated the possible involvement of two conserved aspartic acid residues in transmembrane segments 7 and 8 of EAAC1, Asp-367 and Asp-454, in Na(+) cotransport...
  42. ncbi In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging
    A Pfefferbaum
    Neuropsychiatry Program, Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Magn Reson Med 41:276-84. 1999
    ..Independent determination of metabolite values rather than use of ratios is essential for characterizing age-related changes in brain MRS metabolites...
  43. pmc Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging
    S Mackay
    Magnetic Resonance Spectroscopy Unit, Department of Veterans Affairs Medical Center, San Francisco, USA
    Arch Neurol 53:167-74. 1996
    ..Our findings in subjects with SIVD are consistent with higher levels of creatine-containing metabolites and/or lower levels of NAA in frontal white matter...
  44. ncbi Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice
    Y Ikegaya
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Hippocampus 11:287-98. 2001
    ..These results suggest that the mossy fiber-CA3 system is vulnerable to aspartate isomerization and that the PIMT-mediated repair system is essential for maintenance of normal functions of the hippocampus...
  45. ncbi Quantitative objective markers for upper and lower motor neuron dysfunction in ALS
    H Mitsumoto
    Eleanor and Lou Gehrig MDA ALS Research Center, Columbia University, New York, NY 10032, USA
    Neurology 68:1402-10. 2007
    ..To investigate the value of objective biomarkers for upper (UMN) and lower (LMN) motor neuron involvement in ALS...
  46. ncbi Differential distribution of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat forebrain
    J R Moffett
    Department of Biology, Georgetown University, Washington, DC 20057 1028, USA
    J Neurocytol 24:409-33. 1995
    ..Although N-acetylaspartate-immunoreactivity was found in most neurons, it exhibited a great range of intensities between different neuronal types...
  47. ncbi Simultaneous racemization and isomerization at specific aspartic acid residues in alpha B-crystallin from the aged human lens
    N Fujii
    Discovery Research Division, Takeda Chemical Industries, Ltd, Ibaraki, Japan
    Biochim Biophys Acta 1204:157-63. 1994
    ..We concluded that racemization, isomerization, and oxidation of alpha B-crystallin occur spontaneously in the aging process...
  48. ncbi An excitatory amino-acid transporter with properties of a ligand-gated chloride channel
    W A Fairman
    Howard Hughes Medical Institute, Oregon Health Sciences University, Portland 97201, USA
    Nature 375:599-603. 1995
    ..Thus EAAT4 combines the re-uptake of neurotransmitter with a mechanism for increasing chloride permeability, both of which could regulate excitatory neurotransmission...
  49. ncbi Sustained neuronal activation raises oxidative metabolism to a new steady-state level: evidence from 1H NMR spectroscopy in the human visual cortex
    Silvia Mangia
    Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Cereb Blood Flow Metab 27:1055-63. 2007
    ....
  50. ncbi Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins
    M J Mamula
    Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 274:22321-7. 1999
    ..Isoaspartyl linkages within proteins are enhanced in aging and stressed cells and arise under physiological conditions. These post-translationally modified peptides may serve as an early immunologic stimulus in autoimmune disease...
  51. ncbi The presence of D-beta-aspartic acid-containing peptides in elastic fibers of sun-damaged skin: a potent marker for ultraviolet-induced skin aging
    Noriko Fujii
    Research Reactor Institute, Kyoto University Kumatori, Sennan, Osaka 590 0494, Japan
    Biochem Biophys Res Commun 294:1047-51. 2002
    ..These results suggest that UV irradiation is closely related to the formation of d-beta-Asp in the elastic fibers of skin. We propose that the antibody could be a useful indicator for sun damage of the skin...
  52. ncbi A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder
    Joon Hwan Jang
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul, Korea
    Am J Psychiatry 163:1202-7. 2006
    ..The authors used proton magnetic resonance spectroscopic imaging ((1)H-MRSI) to investigate regional N-acetylaspartate level abnormalities and changes after 12 weeks of pharmacotherapy with citalopram in drug-naive OCD patients...
  53. pmc Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other
    Christof Grewer
    University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, Florida 33136, USA
    Biochemistry 44:11913-23. 2005
    ..In conclusion, we propose that EAAC1 assembles as trimers of identical subunits but that the individual subunits in the trimer function independently of each other...
  54. pmc Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease
    T Chris Gamblin
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 100:10032-7. 2003
    ....
  55. ncbi Identification and characterization of deamidation sites in the conserved regions of human immunoglobulin gamma antibodies
    Dirk Chelius
    Department of Pharmaceutics, Amgen, Inc, Thousand Oaks, California 91320, USA
    Anal Chem 77:6004-11. 2005
    ..Our high-performance liquid chromatography method could separate the succinimide, isoaspartic, and aspartic acid isoforms of peptide fragments generated using trypsin...
  56. pmc Coupled amino acid deamidase-transport systems essential for Helicobacter pylori colonization
    Damien Leduc
    Departement de Microbiologie, Unité Pathogenèse de Helicobacter, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Infect Immun 78:2782-92. 2010
    ..pylori. We propose a model in which these two nonredundant systems participate in H. pylori virulence by depleting gastric or immune cells from protective amino acids such as Gln and producing toxic ammonia close to the host cells...
  57. ncbi Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy
    F A Howe
    Cancer Research UK Biomedical Magnetic Resonance Research Group, Department of Biochemistry and Immunology, St George s Hospital Medical School, Cramner Terrace, London, UK
    Magn Reson Med 49:223-32. 2003
    ..3 lipid signals vs. mI/Cho provided a simple way to separate most tumors by type and grade...
  58. pmc Yeast Skn7p functions in a eukaryotic two-component regulatory pathway
    J L Brown
    Department of Biology, McGill University, Montreal, Quebec, Canada
    EMBO J 13:5186-94. 1994
    ..We present evidence suggesting that Skn7p serves as a transcription factor in such a signaling pathway...
  59. ncbi Suppression of protein l-isoaspartyl (d-aspartyl) methyltransferase results in hyperactivation of EGF-stimulated MEK-ERK signaling in cultured mammalian cells
    Sakurako Kosugi
    Laboratory of Biomolecular Science, School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Biochem Biophys Res Commun 371:22-7. 2008
    ..These results suggest that PIMT repair of abnormal proteins is necessary to maintain normal MAPK signaling...
  60. ncbi Critical aspartic acid residues in pseudouridine synthases
    V Ramamurthy
    Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA
    J Biol Chem 274:22225-30. 1999
    ..Gu, X. G., and Santi, D. V. (1998) Biochemistry 37, 344-351), the Santi group discovered that a single aspartic acid residue is the only amino acid present in all of the aligned sequences; they then demonstrated that this ..
  61. pmc Changes in MRS neuronal markers and T cell phenotypes observed during early HIV infection
    M R Lentz
    Harvard Medical School Massachusetts General Hospital, Building 149, 13th Street, Rm 2301, Charlestown, MA 02129, USA
    Neurology 72:1465-72. 2009
    ..To determine if changes in brain metabolites are observed during early HIV infection and correlate these changes with immunologic alterations...
  62. ncbi 1H-MRS evaluation of metabolism in Alzheimer's disease and vascular dementia
    Randall S Jones
    Department of Imaging, Charing Cross Hospital, London, UK
    Neurol Res 26:488-95. 2004
    ....
  63. ncbi A fission yeast gene (prr1(+)) that encodes a response regulator implicated in oxidative stress response
    R Ohmiya
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya, 464 8601, Japan
    J Biochem 125:1061-6. 1999
    ..g., trr1(+), ctt1(+)), which are induced by oxidative stress. These results suggest that a His-Asp phosphorelay system may be involved in a stress-activated signaling pathway in S. pombe...
  64. ncbi Traffic of botulinum toxins A and E in excitatory and inhibitory neurons
    Claudia Verderio
    Department of Medical Pharmacology, University of Milano, Via Vanvitelli 32, 20129 Milano, Italy
    Traffic 8:142-53. 2007
    ....
  65. pmc Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice
    E Kim
    The Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141 9100, USA
    Proc Natl Acad Sci U S A 94:6132-7. 1997
    ..These results suggest that the ability of mice to repair L-isoaspartyl- and D-aspartyl-containing proteins is essential for normal growth and for normal central nervous system function...
  66. ncbi Asperger syndrome: a proton magnetic resonance spectroscopy study of brain
    Declan G M Murphy
    Department of Psychological Medicine, St George s Hospital Medical School, London, England
    Arch Gen Psychiatry 59:885-91. 2002
    ..Nobody has examined the relationship between abnormalities in the frontal and parietal lobes and clinical symptoms in people with AS...
  67. pmc Serum levels of N-acetyl-aspartate in migraine and tension-type headache
    Marina de Tommaso
    Neuroscience and Sensory System Department, Bari Aldo Moro University, Policlinico General Hospital, Neurological Building, Piazza Giulio Cesare 11, 70124, Bari, Italy
    J Headache Pain 13:389-94. 2012
    ..The low NAA in the serum may be a sign of neuronal dysfunction predisposing to migraine, probably based on reduced mitochondria function...
  68. ncbi Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya Aichi, Japan
    Carcinogenesis 25:1395-401. 2004
    ..936) and that with light smoking was 2.67 (95% CI 1.00-7.68, P = 0.049). These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure...
  69. ncbi Aggrecan turnover in human intervertebral disc as determined by the racemization of aspartic acid
    Sarit S Sivan
    Department of Biomedical Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    J Biol Chem 281:13009-14. 2006
    We have used the racemization of aspartic acid as a marker for the "molecular age" of aggrecan components of the human intervertebral disc matrix (aggregating and non-aggregating proteoglycans as well as the different buoyant density ..
  70. ncbi 1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review
    Zografos Caramanos
    Magnetic Resonance Spectroscopy Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Brain 128:2483-506. 2005
    ..These results also suggest that, although within-voxel tNA/tCr ratios are not perfect indicators of [tNA] content, they do represent a practical compromise to acquiring surrogate measures of within-voxel neuroaxonal integrity...
  71. ncbi Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagings
    I Chan Chiang
    Department of Radiology, Chung Ho Memorial Hospital, Kaohsiung Medical University, No 100 Shih chuan 1st Road, Kaohsiung, Taiwan
    Neuroradiology 46:619-27. 2004
    ..Diffusion-weighted imaging techniques were complementary techniques to make a differential diagnosis between the two malignant tumors...
  72. ncbi The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells
    Blanca Rubi
    Department of Cell Physiology and Metabolism, University Medical Centre, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    J Biol Chem 279:55659-66. 2004
    ..7 mm glucose (+65%, p < 0.05) compared with controls. These results show that aspartate-glutamate carrier capacity limits glucose-stimulated insulin secretion and that Aralar1 overexpression enhances mitochondrial metabolism...
  73. ncbi Biological markers in CSF and blood for axonal degeneration in multiple sclerosis
    Charlotte E Teunissen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands
    Lancet Neurol 4:32-41. 2005
    ..These concepts may be helpful for biomarker research in various neurodegenerative diseases...
  74. ncbi Essential aspartic acid residues, Asp-133, Asp-163 and Asp-164, in the transmembrane helices of a Na+/H+ antiporter (NhaA) from Escherichia coli
    H Inoue
    Department of Biotechnology, Faculty of Engineering, Okayama University, Japan
    FEBS Lett 363:264-8. 1995
    ..These three Asp residues, conserved in the nhaA homologs from different species and which are located closely in the 3rd and 4th putative transmembrane helices, appear to play important roles in cation binding and transport...
  75. ncbi IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha
    A D Howard
    Department of Biochemical and Molecular Pathology, Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065
    J Immunol 147:2964-9. 1991
    ..Substitutions at P2'-P4' and P6' had relatively little effect on cleavage activity. These results show that ICE is a highly specific IL-1 beta convertase with absolute requirements for Asp in P1 and a small hydrophobic amino acid in P1'...
  76. ncbi The catalytic mechanism of dye-decolorizing peroxidase DyP may require the swinging movement of an aspartic acid residue
    Toru Yoshida
    R1 7 Chemical Resources Laboratory, Tokyo Institute of Technology, Japan
    FEBS J 278:2387-94. 2011
    ..On the basis of these results, we propose a swing mechanism in compound I formation. When DyP reacts with hydrogen peroxide, OD2 swings towards an optimal position to accept the proton from hydrogen peroxide bound to the heme iron...
  77. pmc Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T
    Lana G Kaiser
    Department of Radiology, University of California San Francisco, MR Unit, DVA Medical Center 114M, 4150 Clement St, San Francisco, CA 94121, USA
    Neurobiol Aging 26:665-72. 2005
    ..Reduced glutamate and N-acetyl aspartate in the motor cortex is consistent with neuronal loss/shrinkage with age. In conclusion, different patterns in association with normal aging in these brain regions were detected in this study...
  78. pmc Age dependence of regional proton metabolites T2 relaxation times in the human brain at 3 T
    Ivan I Kirov
    Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    Magn Reson Med 60:790-5. 2008
    ..The elderly NAA, Cr, and Cho T(2)s were 12%, 6%, and 10% shorter than the adolescents, a change of under 1 ms/year assuming a linear decline with age. Formulae for T(2) age-correction for higher quantification precision are provided...
  79. pmc BMI and neuronal integrity in healthy, cognitively normal elderly: a proton magnetic resonance spectroscopy study
    Stefan Gazdzinski
    Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Administration Medical Center, San Francisco, California, USA
    Obesity (Silver Spring) 18:743-8. 2010
    ..Future studies need to evaluate whether these metabolite abnormalities are involved in the development and maintenance of weight problems...
  80. ncbi T2 relaxation time abnormalities in bipolar disorder and schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Magn Reson Med 63:1-8. 2010
    ....
  81. pmc Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases, DVA Medical Center, San Francisco, CA 94121, USA
    Psychiatry Res 162:147-57. 2008
    ..NAA appears to be a more sensitive marker for neuronal abnormality in PTSD than brain volume. The alteration in the anterior cingulate cortex in PTSD has implications for fear conditioning and extinction...
  82. ncbi The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel
    B Nilius
    Department of Physiology, Campus Gasthuisberg, KU Leuven, Leuven B 3000, Belgium
    J Biol Chem 276:1020-5. 2001
    ..Mutations of two neighboring negatively charged residues, i.e. Glu(535) and Asp(550), had only minor effects on Ca(2+) permeation properties...
  83. pmc The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters
    Shlomit Teichman
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 106:14297-302. 2009
    ..Thus the conserved aspartate is required for transporter-cation interactions in each of the two separate translocation steps and likely participates in an overlapping sodium and potassium binding site...
  84. pmc Age-related metabolite changes and volume loss in the hippocampus by magnetic resonance spectroscopy and imaging
    N Schuff
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, and University of California, San Francisco, CA 94121, USA
    Neurobiol Aging 20:279-85. 1999
    ..Furthermore, because NAA is considered a marker of neurons, these results provide stronger support for neuron loss in the aging hippocampus than volume measurements by MRI alone...
  85. ncbi Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response
    Wolfgang Block
    Department of Radiology, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 12:415-22. 2009
    ..This accounts in particular for those patients with low NAA and Cho baseline levels...
  86. pmc Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease
    Kejal Kantarci
    Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurobiol Aging 28:1330-9. 2007
    ..Choline/creatine ratio declined in stable MCI, compared to converter MCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in MCI patients who did not to progress to AD...
  87. ncbi Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
    M S Wolfe
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 398:513-7. 1999
    ....
  88. ncbi Brain metabolites in the hippocampus-amygdala region and cerebellum in autism: an 1H-MR spectroscopy study
    H Otsuka
    Department of Radiology, University of Tokushima, Tokushima City, Japan
    Neuroradiology 41:517-9. 1999
    ..616. The decreased NAA concentration may be due to neuronal hypofunction or immature neurons. The NAA concentration in the HA region and cerebellum may be related, because of neuronal circuits or networks...
  89. pmc An MRI and proton spectroscopy study of the thalamus in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Psychiatry Res 163:97-105. 2008
    ..Further investigations of this structure are warranted, since it plays an important role in information processing as part of the cortico-thalamo-cortical pathways...
  90. ncbi Correlation between myocardial malate/aspartate shuttle activity and EAAT1 protein expression in hyper- and hypothyroidism
    J Carter Ralphe
    Department of Pediatrics, Roy and Lucille Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Am J Physiol Heart Circ Physiol 288:H2521-6. 2005
    ..EAAT1 regulation by thyroid hormone may facilitate increased metabolic demands of the cardiomyocyte during hyperthyroidism and impact cardiac function in hyperthyroidism...
  91. ncbi Poly (ethylenimine)-grafted-poly [(aspartic acid)-co-lysine], a potential non-viral vector for DNA delivery
    Gu Ping Tang
    Institute of Bioengineering and Nanotechnology, Singapore
    J Biomater Sci Polym Ed 17:461-80. 2006
    A potential non-viral gene-transfer vector, poly(ethylenimine)-grafted-poly[(aspartic acid)-co-lysine] (PSL), has been developed by thermal polycondensation of aspartic acid and lysine under reduced pressure...
  92. ncbi Absolute quantification in proton magnetic resonance spectroscopy is superior to relative ratio to discriminate Alzheimer's disease from Binswanger's disease
    Toshiyuki Watanabe
    Center of Neurological and Cerebrovascular Diseases, Takeda Hospital, Kyoto, Japan
    Dement Geriatr Cogn Disord 26:89-100. 2008
    ..The aim of this study is to compare the diagnostic accuracy of these 2 methods in proton magnetic resonance spectroscopy in discriminating Alzheimer's disease (AD) and Binswanger's disease (BD) from healthy controls (HC)...
  93. pmc Reproducibility of serial whole-brain MR spectroscopic imaging
    A A Maudsley
    Department of Radiology, University of Miami School of Medicine, Miami, FL 33136, USA
    NMR Biomed 23:251-6. 2010
    ....
  94. ncbi Inhibition of presynaptic release-facilitatory kainate autoreceptors by extracellular cyclic GMP
    Chiara Cervetto
    Department of Experimental Medicine, Pharmacology and Toxicology Section, University of Genoa, Genoa, Italy
    J Pharmacol Exp Ther 332:210-9. 2010
    ..Endogenously synthesized cGMP might be the physiological source for the extracellular cGMP modulating the response to kainate autoreceptor activation...
  95. pmc Reduction of N-acetylaspartate in the medial prefrontal cortex correlated with symptom severity in obsessive-compulsive disorder: meta-analyses of (1)H-MRS studies
    Yuta Aoki
    Department of Psychiatry, Tokyo Metropolitan Health and Medical Treatment Corporation, Ebara Hospital, Ota, Tokyo, Japan
    Transl Psychiatry 2:e153. 2012
    ..The current meta-analysis indicates that cortices and sub-cortices contribute in different ways to the etiology of OCD...
  96. ncbi Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling
    Markus A Seeger
    Institute of Physiology and Zurich Centre for Integrative Human Physiology ZIHP, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Biochemistry 48:5801-12. 2009
    ..This study provides evidence for a substantial role of membrane-located carboxylates as a central element of the proton translocation pathway in AcrB and other members of the RND superfamily...
  97. ncbi Differentiation of SCA2 from MSA-C using proton magnetic resonance spectroscopic imaging
    Sylvia M Boesch
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    J Magn Reson Imaging 25:564-9. 2007
    ..To assess and compare biochemical and volumetric features of the cerebellum in patients with spinocerebellar ataxia type 2 (SCA2) and patients with the cerebellar variant of multiple system atrophy (MSA-C)...
  98. pmc Age estimation in forensic sciences: application of combined aspartic acid racemization and radiocarbon analysis
    Kanar Alkass
    Department of Forensic Medicine, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Mol Cell Proteomics 9:1022-30. 2010
    ..by anthropologists to determine age are often imprecise, whereas chemical analysis of tooth dentin, such as aspartic acid racemization, has shown reproducible and more precise results...
  99. ncbi Function of the frontal lobe in autistic individuals: a proton magnetic resonance spectroscopic study
    Emiko Fujii
    Department of Pediatrics, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Med Invest 57:35-44. 2010
    ..In this investigation, we studied differences in chemical metabolites in certain brain regions between autistic patients and normal control subjects...
  100. ncbi Kinetic and structural studies on the catalytic role of the aspartic acid residue conserved in copper amine oxidase
    Yen Chen Chiu
    Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochemistry 45:4105-20. 2006
    ..On the basis of these results, we propose that the stereospecificity of alpha-proton abstraction is primarily determined by the conformation of TPQ(ssb), rather than the relative geometry of TPQ and the catalytic base...
  101. ncbi Amyotrophic lateral sclerosis: diffusion-tensor and chemical shift MR imaging at 3.0 T
    Sumei Wang
    Department of Radiology, Division of Neuroradiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Dulles 2, Philadelphia, PA 19104, USA
    Radiology 239:831-8. 2006
    ....

Research Grants73

  1. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..Lessons learnt from understanding the role of ezrin in B cell function can be applied towards therapeutic design for B cell-dependent human diseases. ..
  2. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
    ....
  3. Parvalbumin-Containing Neurons in Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2013
    ..Findings of the proposed studies are expected to shed light on the conceptualization of treatment and prevention strategies that aim at fundamentally correcting the underlying neural circuit deficits. ..
  4. Reversing Corticosteroid-Induced Memory Impairment
    E Sherwood Brown; Fiscal Year: 2013
    ..The impact of lamotrigine on memory, mood, quality of life, structural imaging, and spectroscopy will be examined. ..
  5. Metal-dependent phosphohydrolase activity of CvfA from Streptococcus pyogenes
    GABRIELA CITLALLI PEREZ-ALVARADO; Fiscal Year: 2012
    ..This will allow us to begin developing therapeutic measures against streptococcal diseases based on our knowledge of CvfA. ..
  6. MECHANISM AND CONTROL OF UREA BIOSYNTHESIS
    Frank M Raushel; Fiscal Year: 2011
    ..Asparagine synthetase A is known to catalyze the formation of asparagine from ATP, ammonia, and aspartic acid. However, this enzyme has recently been implicated in the biosynthesis of an extracellular death factor ..
  7. Plasminogen activators and NMDA after brain injury
    William M Armstead; Fiscal Year: 2012
    ..Immunohistochemistry, detection of plasminogen activator and MAPK expression, and CBF determination by radiolabled microspheres will be performed. ..
  8. Autoimmunity Against Novel Antigens in Neuropsychiatric Dysfunction
    Josep O Dalmau; Fiscal Year: 2013
    ....
  9. Liver cancer risk and prevention among persons living with HIV/AIDS
    LESLEY SUEJEAN PARK; Fiscal Year: 2013
    ....
  10. Effect of D-cycloserine on treatment of PTSD in youth
    Michael S Scheeringa; Fiscal Year: 2010
    ..and urinary tract infections, is a partial agonist at the glycine modulatory site of the N-methyl- D-aspartic acid (NMDA) receptor...
  11. Role of Cited2 in Hematopoiesis
    Yu Chung Yang; Fiscal Year: 2011
    Cited2 [CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2] is one of the founding members of a new family of transcriptional modulators...
  12. Presynaptic NMDAR Regulation of Substance P Release in the RVM After Injury
    UCHECHUKWU PATRICK MADUKA; Fiscal Year: 2013
    ....
  13. Developing small molecule therapeutics for lupus
    Thomas R Coleman; Fiscal Year: 2012
    ..The net result of this effort will be to develop a novel treatment for SLE and improve the lives of Americans. ..
  14. The Contribution of Protein Methylation in Systemic Lupus Erythematosus
    Hester A Doyle; Fiscal Year: 2011
    ..the inflammatory process that occurs with lupus, protein methylation reactions, such as the conversion of aspartic acid to isoaspartic acid and arginine methylation, increase...
  15. Exercise training improves erectile dysfunction in diabetes: role of central mech
    Kaushik P Patel; Fiscal Year: 2012
    ..streptozotocin (STZ)-induced type I diabetes (T1D) the erectile response to central administrated N-methyl-D-aspartic acid (NMDA) in the PVN is blunted, 2) NMDA-induced erection is nitric oxide (NO)-mediated, 3) neuronal NO synthase (..
  16. Role of Gprotein and SNAP-25 in NMDA vs mGluR presynaptic long-term plasticity
    KATISHA ROSE GOPAUL; Fiscal Year: 2013
    ..The N-Methyl-D-aspartic acid receptor (NMDAR) is crucial for the induction of presynaptic and postsynaptic forms of both LTP and LTD, while ..
  17. Blood Coagulation Protein - Metal Ion - Lipid Interactions
    Francis J Castellino; Fiscal Year: 2013
    ..This proposal is concerned with the complex mechanisms of action of the conantokins in vitro and in vivo and relating these properties to their neuroprotective effects in a model of occlusive stroke. ..
  18. TWIN STUDY OF BIOLOGIC MARKERS FOR PTSD
    Lisa M Shin; Fiscal Year: 2012
    ..Abnormalities that are found to be acquired could become the target of PTSD treatments, whereas abnormalities that serve as risk factors for PTSD could be used in screening for persons at risk and possible preventive interventions. ..
  19. Synthesis of bone-selective osteogenic oxysterols
    Frank Stappenbeck; Fiscal Year: 2013
    ....
  20. Implications of Endothelial-Myocyte Uncoupling in Cardiac Arrhythmia
    Suresh C Tyagi; Fiscal Year: 2010
    ..These studies will delineate the mechanism of Hcy-dependent endothelial-myocyte uncoupling in cardiac arrhythmia and failure, and will have therapeutic ramifications for sudden cardiac death. ..
  21. Hepatoma derived growth factor and vascular smooth muscle cell proliferation
    Allen D Everett; Fiscal Year: 2010
    ..of single or combination mutations of candidate PKC serines (S) to alanine (A, loss of phosphorylation) or aspartic acid (D, phosphorylation mimic) mutations, PKCa deficient knockout mice, and phospho-specific HDGF antibodies...
  22. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 2009
    ..The potential role of CREB dephosphorylation as a result of over activation of NMDA receptors will also be assessed in the neurotoxicity of PCP treatment. ..
  23. Vervet Monkey: Modeling Effects of Diet-Induced Obesity on Reproduction
    Alex Joel Polotsky; Fiscal Year: 2011
    ..To test the hypothesis that obesity dampens GnRH pulsatility, hypothalamic responsiveness to N-Methyl-D-aspartic acid will be assessed...
  24. Variants in nicotine receptors and pharmacogenetics
    Xiangning Chen; Fiscal Year: 2010
    ..One of the variants, SNP rs16969968, changes the 398th amino acid from aspartic acid (D) to asparagine (N) (D398N) in the CHRNA5 gene...
  25. Mechanism of action of novel GluN2C NMDA receptor potentiators
    Alpa Khatri; Fiscal Year: 2013
    ..The data from this research could potentially be useful for developing new therapies for neurological disorders thought to be associated with aberrant NMDA receptor function such as, schizophrenia, autism, and psychosis. ..
  26. Defining the epitope in antiNMDA receptor encephalitis
    DAVID ROBINSON LYNCH; Fiscal Year: 2010
    ..Through understanding of this process, the proposal may facilitate therapies for preventing damage in this disorder and a basic understanding of other neurologic disorders such as stroke. ..
  27. Central Mechanisms of Orofacial Pain
    Jianren Mao; Fiscal Year: 2012
    ..The outcome of this study could lead to the development of new therapeutic tools to treat often intractable and debilitating clinical orofacial pain. ..
  28. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2011
    ..This application represents a multidisciplinary approach to build on a novel model for neuropsychiatric manifestations of lupus and a novel paradigm for antibody-mediated changes in cognition and behavior. ..
  29. PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSION
    Patric K Stanton; Fiscal Year: 2012
    ..The long-term regulation of transmitter release has far-reaching importance to normal synaptic processing dynamics, and controlling pathologic glutamate release during injury or disease. ..
  30. Host pathogen signaling in the intestine
    Vanessa Sperandio; Fiscal Year: 2013
    ..In accordance, the Specific Aim of this application is: Characterize the contribution of the host Epi/NE hormones to C. rodentium pathogenesis during murine infection. ..
  31. Neurovascular Protection for Early Brain Injury after SAH
    John H Zhang; Fiscal Year: 2013
    ....
  32. Quantitative MR Imaging &Proton Spectroscopy in MS.
    Yulin Ge; Fiscal Year: 2013
    ..It will result in more appropriate measures to detect and quantitate the effect of the disease and will provide a rationale for innovative treatment regimes. ..
  33. Protein S: Neurovascular Protection in Stroke
    Berislav V Zlokovic; Fiscal Year: 2010
    ..B. Berk (Rochester) (Tyro 3 RTK-Akt signaling) and Dr. M. Chopp (Henry Ford) (rat stroke model). The results will provide mechanistic insights and test therapeutic agents that may be translated to improved therapy for ischemic stroke. ..
  34. Ph 2 Study of Dextromethorphan in the Treatment of Rett Syndrome
    SAKKUBAI R NAIDU; Fiscal Year: 2013
    ..Analyses will be done on an intention-to-treat basis. Our previous study showing improved alertness and social interaction on neuropsychological and behavioral assessments is encouraging. ..
  35. IDO Regulation in the SIV Model of HIV CNS Disease
    M Christine Zink; Fiscal Year: 2013
    ..The Kyn metabolite quinolinic acid leads to neurodegeneration by promoting NMDA (N-methyl-D-aspartic acid) receptor-mediated excitotoxicity...
  36. Development of Human Asparaginase for Cancer Therapy
    Arnon Lavie; Fiscal Year: 2013
    ..The activity of this enzyme is to hydrolyze the amino acid asparagine to aspartic acid and ammonia. Certain blood cancers are dependent on the extracellular pool of asparagine...
  37. DAPK1 regulation of NMDA receptors in ischemic neuronal death
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2012
    ..Thus, this approach should not affect the physiological actions of glutamate receptors in the brain, thereby defining a promising target for stroke therapy. ..
  38. Role of Ubiquitin in Cardiovascular System
    Song Li; Fiscal Year: 2013
    ..1 ..
  39. Real-time imaging of tPA fluorescent hybrids in hippocampal neurons
    Janis E Lochner; Fiscal Year: 2011
    ..tPA-mediated extracellular proteolysis is also implicated in excitotoxic cell death and the neuronal degeneration associated with Alzheimer<s disease. ..
  40. Attenuation of Corticosteroid-Induced Hippocampal Changes
    E Sherwood Brown; Fiscal Year: 2013
    ..The findings will have implications for patients with mood disorders, substance use disorders, dementias, Cushing's disease, and the millions treated each year with prescription corticosteroids. ..
  41. Integrated Analyses of Taspase 1 (MLL Cleaving Protease)
    James J D Hsieh; Fiscal Year: 2010
    ..abstract_text> ..
  42. Cysteine Proteases in Apoptosis
    Emad S Alnemri; Fiscal Year: 2012
    ..The results of this research will help in the design and discovery of effective therapeutics to treat autoinflammatory diseases. ..
  43. Molecular Mechanisms Linking HLA-DQ and Autoimmunity
    Luc Teyton; Fiscal Year: 2013
    ..share with HLA-DQ2, HLA-DR0405 and I-Ag7 a mutation at position 57 of their chain that eliminates a conserved aspartic acid and modifies the charge and shape of the P9 pocket...
  44. Assessing GABAergic Involvement in Schizophrenia-Like Cognitive Deficits in Rats
    Mark Renato Stefani; Fiscal Year: 2012
    ....
  45. Cyr61-induced breast cancer: Clinical relevance and therapeutic development
    Ruth Lupu; Fiscal Year: 2010
    ..e., Cyr61/alpha-v-beta3). In addition, we will evaluate the relevance of a Cyr61- triggered "Cyr61/alpha-v-beta3 integrin loop" as a novel predictive marker for response to chemotherapy in breast cancer. ..
  46. Structural Biology of Multifunctional Bacterial Phosphatases
    Matthew B Neiditch; Fiscal Year: 2012
    ..protein in the sporulation signal transduction pathway, catalyzes the dephosphorylation of a regulatory aspartic acid. Another subset of Rap proteins downregulates the development of genetic competence in B...
  47. Role of Cited2 in lens development and hyaloid vascular regression
    Yu Chung Yang; Fiscal Year: 2010
    Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a founding member of a new family of transcriptional modulators...
  48. Role NR1/2C and NR1/2D NMDA Receptors in Cortex Function and Memantine Action
    Jon W Johnson; Fiscal Year: 2012
    ..Understanding how memantine helps patients with Alzheimer's disease may lead to the design of improved Alzheimer's disease treatments. ..
  49. Mechanisms of nicotine-induced neuroplasticity
    Katumi Sumikawa; Fiscal Year: 2013
    ..Results from this study will likely lead to a better understanding of addiction processes and may aid in developing therapies for preventing the relapse, and thereby promoting smoking cessation. ..
  50. Clinical Translation of a Neuron Protective Recombinant Human Antibody
    Moses Rodriguez; Fiscal Year: 2012
    ..abstract_text> ..
  51. Novel gene therapy strategies for Canavan disease
    Guang Ping Gao; Fiscal Year: 2013
    ..ASPA deficiency in Canavan patients leads to accumulation of N-Acetyl-Aspartic Acid (NAA), resulting in swelling and spongy degeneration of white matter in the brain...
  52. DEVELOPMENTAL REGULATION OF GLUTAMATE RECEPTOR FUNCTION
    MARTHA NA CONSTANTINE-PATON; Fiscal Year: 2012
    ..Our work identifying mechanisms of functional connectivity in visual development will also help in integrating visual prosthetics for retinal dysfunction into the brain circuits that produce vision. ..
  53. The Role of Microglia and the Kynurenine Pathway in Huntington's Disease
    Paul J Muchowski; Fiscal Year: 2012
    ..If successful, our studies may lead to clinical tests of small molecule inhibitors of the pathway in patients with Huntington's disease. ..
  54. High Throughput Screening for nAChRs: Cell Lines and Assay Development
    Yingxian Xiao; Fiscal Year: 2011
    ..The goal of this project is to develop high throughput screening assay that will accelerate the development of selective ligands. ..
  55. Proton-Translocating Sector of E. coli H+ATP Synthase
    Robert H Fillingame; Fiscal Year: 2010
    ....
  56. Alpha 5 Nicotinic Receptor Subunit Gene Polymorphisms and Smoking Addiction
    Alexey G Mukhin; Fiscal Year: 2013
    ..risk allele for non-synonymous coding SNP a5 subunit gene (rs16969968), which causes the substitution of an aspartic acid with asparagine and results in decreased function of the nicotinic receptor...
  57. Olivocerebellar Circuitry in Autism
    Gene J Blatt; Fiscal Year: 2010
    ..abstract_text> ..
  58. Critical functions specified by the MLL CXXC domain determine leukemogenic capaci
    NOAH WARREN BIRCH; Fiscal Year: 2012
    ..We hypothesize that these are critical determination features for MLL's role in acute leukemia. Keywords: MLL, MLL2, leukemia, hematopoiesis ..
  59. Structure and Function of NMDA Receptors
    Hiroyasu Furukawa; Fiscal Year: 2013
    ..Defining the molecular structure of the extracellular region of NMDA receptors is expected to help in the design of new therapeutics. ..
  60. Enzyme Delivery With Supercharged Proteins to Address Citrullinemia
    John Zuris; Fiscal Year: 2013
    ..Here I propose to systematically address the possibility that the direct delivery of AS1 into hepatocytes using SCPs can rescue the metabolic deficiency in citrullinemia cells both in cell culture and in vivo. ..
  61. Macrophages, NR2B-containing NMDA Receptors and HIV Dementia
    HUANGUI HANK XIONG; Fiscal Year: 2013
    Synaptic N-methyl-D-aspartic acid (NMDA) receptors (NMDARs), composed, in large part, of NR2A-containing NMDARs (NR2ARs), promote cell survival, whereas extrasynaptic NMDARs, NR2B-containing NMDARs (NR2BRs), induce cell death...
  62. Regulation of MTG16 and Notch signaling in hematopoiesis
    MICHAEL E ENGEL; Fiscal Year: 2013
    ..Understanding normal blood cell development and its regulation is essential to develop effective interventions for problems of blood cell development generally, and may disclose new therapeutic targets for cancers of the blood. ..
  63. Therapeutic for Intracerebral Hemorrhage
    Dale Christensen; Fiscal Year: 2009
    ....
  64. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    ..a common DQ1 subtype that does not confer susceptibility to PV only at a single position of the DQbeta chain (aspartic acid/valine at DQbeta 57)...
  65. MECHANISMS & INHIBITORS OF PYRIDOXAL-DEPENDENT ENZYMES
    DAVID METZLER; Fiscal Year: 1993
    ....
  66. STUDIES OF NEURONAL AND GLIAL GLUTAMATE DECARBOXYLASES
    Jang Yen Wu; Fiscal Year: 1990
    ..We plan to use hybridoma technique which we have successfully developed for neuronal GAD to obtain monoclonal antibody to glial GAD...
  67. ONTOGENY AND HORMONAL CONTROL OF CARDIAC NADH SHUTTLES
    Thomas Scholz; Fiscal Year: 2001
    ....
  68. Bone Targeting Peptides for the Prevention and Treatment of Infection
    HANNE GRON; Fiscal Year: 2009
    ..The use of general bone-binding moieties such as bisphosphonates, poly-aspartic acid and tetracycline provides preliminary evidence that localized drug delivery to bone is possible in numerous in ..
  69. Development of a Model to Examine Corticosteroid Effects on the Hippocampus
    E Sherwood Brown; Fiscal Year: 2009
    ..The study will determine if phenytoin, a medication used for seizures, protects the human brain from the adverse effects of cortisol. ..
  70. Control of Cardiac Metabolism: NADH Shuttles/Hypertrophy
    Thomas Scholz; Fiscal Year: 2006
    ..A complete understanding of this pathway is essential to fully define the interaction between these two compartments. [unreadable] [unreadable]..
  71. Balanced, polyvalent antiglutamatergic action as a novel approach to efficacious
    Anatoly Martynyuk; Fiscal Year: 2009
    ....
  72. Poly (amino acid) as an Integrin Targeted Drug Carrier
    Xiaoling Li; Fiscal Year: 2005
    ..It is reported that the recognition of the tripeptide sequence, leucine-aspartic acid-valine, (LDV) is limited only to the a4a1 integrin...
  73. ASPARTATE TRANSMISSION
    J Victor Nadler; Fiscal Year: 2005
    ..This project will eventually shed light on developmental and neurodegenerative processes, including the pathophysiology and pathology associated with epileptic seizures and hypoglycemia. ..