Friend murine leukemia virus

Summary

Alias: Friend murine leukemia virus F-MuLV, F-MULV

Top Publications

  1. ncbi Effects of tacrolimus on infection of Friend murine leukemia virus to Fv-4 gene heterozygous mice
    Feng Min Zhang
    Department of Microbiology, Harbin Medical University, Harbin 150086, China
    Acta Pharmacol Sin 25:208-12. 2004
  2. ncbi Cross-species infectivity and pathogenesis of the Friend murine leukemia virus complex in Syrian hamsters
    Xiaobei Chen
    Department of Microbiology, Pathology, Harbin Medical University, Bio Pharmacological Key Laboratory, Heilongjiang Province 150086, China
    Virus Res 130:281-4. 2007
  3. pmc Host genes conferring resistance to a central nervous system disease induced by a polytropic recombinant Friend murine retrovirus
    R S Buller
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 64:493-8. 1990
  4. doi Inhibition of viral carcinogenesis by Phyllanthus amarus
    Kuzhuvelil B Harikumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Integr Cancer Ther 8:254-60. 2009
  5. pmc Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth
    Y Ben-David
    Sunnybrook Health Science Centre, Toronto, Ontario, Canada
    Mol Cell Biol 12:4449-55. 1992
  6. pmc Interference established in mice by infection with Friend murine leukemia virus
    T Mitchell
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison 53706
    J Virol 66:5696-702. 1992
  7. pmc DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
    Jason Rice
    Molecular Immunology Group, Cancer Sciences Division, University of Southampton School of Medicine, Southampton, UK
    Eur J Immunol 38:2118-30. 2008
  8. pmc Friend erythroleukemia antigen. A viral antigen specified by spleen focus-forming virus and differentiation antigen controlled by the Fv-2 locus
    R Risser
    J Exp Med 149:1152-67. 1979
  9. pmc Env-derived gp55 gene of Friend spleen focus-forming virus specifically induces neoplastic proliferation of erythroid progenitor cells
    S Aizawa
    Laboratory of Molecular Oncology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    EMBO J 9:2107-16. 1990
  10. pmc The potent enhancer activity of the polycythemic strain of spleen focus-forming virus in hematopoietic cells is governed by a binding site for Sp1 in the upstream control region and by a unique enhancer core motif, creating an exclusive target for PEBP/CB
    C Baum
    Heinrich Pette Institute for Experimental Virology and Immunology, Department of Cell and Virus Genetics, Hamburg, Germany
    J Virol 71:6323-31. 1997

Research Grants

  1. JAQUELIN PAGE DUDLEY; Fiscal Year: 2014
  2. Nanoparticle Analysis of Enveloped Virus Entry Pathways
    Robert Davey; Fiscal Year: 2009
  3. Receptor Trafficking in Entry of Murine Leukemia Viruses
    Robert A Davey; Fiscal Year: 2011
  4. WALTHER H MOTHES; Fiscal Year: 2016
  5. MOLECULAR ENGINEERING OF RETROVIRAL VACCINES
    Edward Stephens; Fiscal Year: 1990
  6. Role of the STK Receptor in Erythropoiesis
    Pamela Hankey; Fiscal Year: 2009
  7. FUNCTIONAL ROLE OF FLI-1 IN NEOPLASIA
    E Reddy; Fiscal Year: 2000
  8. MURINE STK RECEPTOR AND MACROPHAGE ACTIVATION
    PAMELA CORRELL; Fiscal Year: 2002

Patents

  1. Viral nucleic acid microarray and method of use
  2. Viral vectors comprising a nucleic sequence derived from murine leukemia viruses for gene transfer in cells
  3. RETROVIRAL VECTOR FOR THE TRANSFER AND EXPRESSION OF GENES FOR THERAPEUTICAL PURPOSES IN EUCARYOTIC CELLS
  4. Retroviral vector particles and methods for their generation and use
  5. RETROVIRAL VECTOR PARTICLES AND METHODS FOR THEIR GENERATION AND USE

Scientific Experts

Detail Information

Publications123 found, 100 shown here

  1. ncbi Effects of tacrolimus on infection of Friend murine leukemia virus to Fv-4 gene heterozygous mice
    Feng Min Zhang
    Department of Microbiology, Harbin Medical University, Harbin 150086, China
    Acta Pharmacol Sin 25:208-12. 2004
    To investigate the effect of tacrolimus (FK506) on the infection of Friend murine leukemia virus (Friend MuLV) in vivo.
  2. ncbi Cross-species infectivity and pathogenesis of the Friend murine leukemia virus complex in Syrian hamsters
    Xiaobei Chen
    Department of Microbiology, Pathology, Harbin Medical University, Bio Pharmacological Key Laboratory, Heilongjiang Province 150086, China
    Virus Res 130:281-4. 2007
    To investigate cross-species infectivity and pathogenesis of Friend murine leukemia virus (MuLV) in hamsters, we infected newborn Syrian hamsters with ecotropic Friend MuLV that was passaged in BALB/c mice for approximately 30 years...
  3. pmc Host genes conferring resistance to a central nervous system disease induced by a polytropic recombinant Friend murine retrovirus
    R S Buller
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 64:493-8. 1990
    Infection of certain strains of mice with the ecotropic Friend murine leukemia virus results in the generation of recombinant polytropic mink cell focus-inducing viruses and the development of erythroleukemia...
  4. doi Inhibition of viral carcinogenesis by Phyllanthus amarus
    Kuzhuvelil B Harikumar
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
    Integr Cancer Ther 8:254-60. 2009
    b>Friend murine leukemia virus (FMuLv) is an acutely oncogenic retrovirus, and its infection leads to erythroblastosis and leukemia in mice. This infection model is used in the search for new antiviral agents...
  5. pmc Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: evidence that A1 is not essential for cell growth
    Y Ben-David
    Sunnybrook Health Science Centre, Toronto, Ontario, Canada
    Mol Cell Biol 12:4449-55. 1992
    ..designated Fli-2 (Friend leukemia virus integration-2), in an erythroleukemia cell line induced by Friend murine leukemia virus (F-MuLV)...
  6. pmc Interference established in mice by infection with Friend murine leukemia virus
    T Mitchell
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison 53706
    J Virol 66:5696-702. 1992
    ..We established retroviral interference in mice by infecting them with Friend murine leukemia virus and them measured susceptibility to superinfection by challenging the mice with the ..
  7. pmc DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
    Jason Rice
    Molecular Immunology Group, Cancer Sciences Division, University of Southampton School of Medicine, Southampton, UK
    Eur J Immunol 38:2118-30. 2008
    ..tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitope derived from Friend murine leukemia virus gag protein (FMuLV(gag)) and vaccinated tolerant FMuLV(gag)-transgenic (gag-Tg) mice...
  8. pmc Friend erythroleukemia antigen. A viral antigen specified by spleen focus-forming virus and differentiation antigen controlled by the Fv-2 locus
    R Risser
    J Exp Med 149:1152-67. 1979
    ..The similarity of FE antigen to Abelson antigen may provide insight into the pathogenic properties of defective transforming MuLV...
  9. pmc Env-derived gp55 gene of Friend spleen focus-forming virus specifically induces neoplastic proliferation of erythroid progenitor cells
    S Aizawa
    Laboratory of Molecular Oncology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    EMBO J 9:2107-16. 1990
    ..One such virus is the replication defective component of the Friend murine leukemia virus (F-MuLV) complex, called Friend spleen focus forming virus (F-SFFV)...
  10. pmc The potent enhancer activity of the polycythemic strain of spleen focus-forming virus in hematopoietic cells is governed by a binding site for Sp1 in the upstream control region and by a unique enhancer core motif, creating an exclusive target for PEBP/CB
    C Baum
    Heinrich Pette Institute for Experimental Virology and Immunology, Department of Cell and Virus Genetics, Hamburg, Germany
    J Virol 71:6323-31. 1997
    ..Using electrophoretic mobility shift assays, we show that the UCR of SFFVp, but not of Friend murine leukemia virus, is targeted by the ubiquitous transcriptional activator, Sp1...
  11. ncbi Characterization of an internal ribosomal entry segment within the 5' leader of avian reticuloendotheliosis virus type A RNA and development of novel MLV-REV-based retroviral vectors
    M Lopez-Lastra
    LaboRetro, Unité de Virologie Humaine INSERM U412, Ecole Normale Superieure de Lyon, France
    Hum Gene Ther 8:1855-65. 1997
    ..Recent studies have shown that the 5' leader of Friend murine leukemia virus and Moloney murine leukemia virus can direct cap independent translation of gag precursor proteins (..
  12. ncbi Identification of genetic determinants that regulate tumorigenicity of Friend murine leukemia virus in rats
    Sayaka Takase-Yoden
    Institute of Life Science, Soka University, Hachioji, Tokyo 192 8577, Japan
    Microbiol Immunol 46:885-90. 2002
    A neuropathogenic variant of Friend murine leukemia virus (FrMLV), clone A8, has been shown to cause thymoma and infiltration of leukemic cells to organs at 7-8 weeks post-infection in rats with a more rapid progression than clone 57...
  13. ncbi Cerebral metabolism in brains of rats infected with neuropathogenic murine leukemia viruses
    Tomoyuki Kanamatsu
    Department of Environmental Engineering for Symbiosis, Faculty of Engineering, Soka University, Hachioji, Tokyo 192 8577, Japan
    J Vet Med Sci 68:259-65. 2006
    b>Friend murine leukemia virus A8 and PVC211 cause spongiform neurodegeneration in rat brains...
  14. pmc Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses
    Géraldine Schlecht-Louf
    Unité Mixte de Recherche 8122 Institut Gustave Roussy, 94805 Villejuif, and Université Paris Sud, 91405 Orsay, France
    Proc Natl Acad Sci U S A 107:3782-7. 2010
    ..we genetically "switched off' the envelope-mediated immunosuppression of an infectious retrovirus, the Friend murine leukemia virus, while preserving mutant envelope infectivity both ex vivo and in vivo, thus allowing us to test the ..
  15. pmc The 0.3-kb fragment containing the R-U5-5'leader sequence of Friend murine leukemia virus influences the level of protein expression from spliced mRNA
    Yeng Cheng Choo
    Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo 192 8577, Japan
    Virol J 10:124. 2013
    A neuropathogenic variant of Friend murine leukemia virus (Fr-MLV) clone A8 induces spongiform neurodegeneration when infected into neonatal rats...
  16. doi A 38 nt region and its flanking sequences within gag of Friend murine leukemia virus are crucial for splicing at the correct 5' and 3' splice sites
    Akihito Machinaga
    Department of Bioinformatics, Faculty of Engineering, Soka University, 1 236, Tangi machi, Hachioji, Tokyo, 192 8577, Japan
    Microbiol Immunol 58:38-50. 2014
    The genome of the Friend murine leukemia virus (Fr-MLV) contains a 5' splice site (5'ss) located at 205 nt and a 3'ss located at 5489 nt...
  17. pmc Novel bifunctional single-chain variable antibody fragments to enhance virolysis by complement: generation and proof-of-concept
    Georg Huber
    Division of Virology, Innsbruck Medical University, Peter Mayr Straße 4b, 6020 Innsbruck, Austria
    Biomed Res Int 2014:971345. 2014
    ..recombinant bifunctional single-chain variable fragment (scFv) based on a monoclonal antibody against Friend murine leukemia virus (F-MuLV) envelope protein gp70, which was coupled to specific binding domains (short consensus repeats ..
  18. pmc Friend spleen focus-forming virus induces factor independence in an erythropoietin-dependent erythroleukemia cell line
    S K Ruscetti
    National Cancer Institute, Bethesda, Maryland 20892
    J Virol 64:1057-62. 1990
    ..of an Epo-dependent erythroleukemia cell line, HCD-57, derived from a mouse infected at birth with Friend murine leukemia virus, afforded us the opportunity to study the direct effect of SFFVP on a homogeneous population of factor-..
  19. pmc Structural elements in glycoprotein 70 from polytropic Friend mink cell focus-inducing virus and glycoprotein 71 from ecotropic Friend murine leukemia virus, as defined by disulfide-bonding pattern and limited proteolysis
    M Linder
    Biochemisches Institut am Klinikum, , Giessen, Germany
    J Virol 68:5133-41. 1994
    ..and compared with that of glycoprotein 71 (gp71), the corresponding glycoprotein of the ecotropic Friend murine leukemia virus, which had previously been determined (M. Linder, D. Linder, J. Hahnen, H.-H. Schott, and Stirm, Eur. J...
  20. pmc Spi-1/PU.1 is a positive regulator of the Fli-1 gene involved in inhibition of erythroid differentiation in friend erythroleukemic cell lines
    J Starck
    , CNRS UMR 5534, 69622 Villeurbanne, France
    Mol Cell Biol 19:121-35. 1999
    ..insertion in most erythroleukemic cell lines induced by the spleen focus-forming virus (SFFV) and Friend murine leukemia virus (F-MuLV) components of the Friend viral complex, respectively...
  21. ncbi The GATA-1 and Spi-1 transcriptional factors bind to a GATA/EBS dual element in the Fli-1 exon 1
    B Barbeau
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Oncogene 18:5535-45. 1999
    ..Supershift analysis also demonstrated the binding of the GATA-1 factor to the GATA/EBS dual element. Our results suggest that Spi-1 and GATA-1 might play a key role in the regulation of Fli-1...
  22. pmc Analysis of the disease potential of a recombinant retrovirus containing Friend murine leukemia virus sequences and a unique long terminal repeat from feline leukemia virus
    Kazuo Nishigaki
    Basic Research Laboratory, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    J Virol 76:1527-32. 2002
    ..of this unique FeLV LTR, we replaced the U3 region of the LTR of the erythroleukemia-inducing Friend murine leukemia virus (F-MuLV) with that of FeLV clone 33...
  23. ncbi F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4
    J Kone
    Department of Pathology, Yale University, New Haven, CT, USA
    Leukemia 16:1827-34. 2002
    ..Infection of transgenic mice with Friend murine leukemia virus (F-MuLV) shortened the latency of morbidity to 103 days (P< 0...
  24. pmc Transduction of nondividing human macrophages with gammaretrovirus-derived vectors
    Loraine Jarrosson-Wuilleme
    LaboRetro, INSERM U412, Ecole Normale Superieure de Lyon, IFR 128 Biosciences Lyon Gerland, 46 allee d Italie, 69364 Lyon, France
    J Virol 80:1152-9. 2006
    ..that human nondividing macrophages display a specific window of susceptibility to transduction with a Friend murine leukemia virus (F-MLV)-derived vector during their differentiation from monocytes...
  25. doi A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70
    Maki Hasegawa
    Department of Comprehensive Pathology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Leuk Res 33:1100-7. 2009
    ..Here, we show that the transduction of the env-gene (gp70) of Friend murine leukemia virus (F-MuLV) sensitized C3H-derived myeloid leukemia cells to DNA-damage (ionizing radiation as well as ..
  26. pmc Co-infection with the friend retrovirus and mouse scrapie does not alter prion disease pathogenesis in susceptible mice
    Pascal Leblanc
    Universite de Lyon, Lyon, France
    PLoS ONE 7:e30872. 2012
    ..Thus, retroviral co-infection does not necessarily alter prion disease pathogenesis in vivo, most likely because of different cell-specific sites of replication for scrapie and F-MuLV...
  27. ncbi Histopathologic studies on myeloproliferative sarcoma virus (MPSV) induced leukemias and hemangiosarcoma in Jar-2 rats
    Y Hayashi
    Department of Pathology, Faculty of Medicine, University of Tokyo, Japan
    Pathol Res Pract 183:314-20. 1988
    ..Intravenous one shot inoculation of myeloproliferative sarcoma virus (MPSV) with Friend murine leukemia virus (F-MuLV) as a helper in newborn Jar-2 rats (on the second neonatal day) yielded hematopoietic ..
  28. pmc Requirement of the single base insertion at the 3' end of the env-related gene of Friend spleen focus-forming virus for pathogenic activity and its effect on localization of the glycoprotein product (gp55)
    H Amanuma
    Tsukuba Life Science Center, Institute of Physical and Chemical Research, Ibaraki, Japan
    J Virol 63:4824-33. 1989
    ..single base insertion and the 6-base-pair duplication was replaced by the corresponding sequence of the Friend murine leukemia virus env gene...
  29. pmc The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus
    R S Buller
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840
    J Exp Med 167:1535-46. 1988
    ..studies designed to examine the possible association of this endogenous gp70 with resistance of mice to Friend murine leukemia virus (F-MuLV)-induced erythroleukemia...
  30. pmc A preferred region for integration of Friend murine leukemia virus in hematopoietic neoplasms is closely linked to the Int-2 oncogene
    J Silver
    J Virol 60:1156-8. 1986
    Gene mapping experiments show that Fis-1, a preferred integration region for Friend murine leukemia virus in hematopoietic neoplasms, is extremely closely linked to Int-2, a preferred integration region for mouse mammary tumor virus in ..
  31. pmc Common proviral integration region on mouse chromosome 7 in lymphomas and myelogenous leukemias induced by Friend murine leukemia virus
    J Silver
    J Virol 57:526-33. 1986
    b>Friend murine leukemia virus (F-MuLV) induces a variety of hematopoietic neoplasms 2 to 12 months after inoculation into newborn mice...
  32. pmc fim-1 and fim-2: two new integration regions of Friend murine leukemia virus in myeloblastic leukemias
    B Sola
    J Virol 60:718-25. 1986
    ..Rearrangements of these two regions were found in F-MuLV-induced myeloblastic leukemias but not in 20 lymphoid or erythroid leukemias induced by the same virus...
  33. pmc Rearrangement and expression of erythropoietin genes in transformed mouse cells
    J McDonald
    Mol Cell Biol 7:365-70. 1987
    The erythroleukemia cell line IW32, derived by transformation with the Friend murine leukemia virus, has been shown previously to produce erythropoietin (EPO) constitutively...
  34. pmc Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells
    M Iwashiro
    Institute for Immunology, Faculty of Medicine, Kyoto University, Japan
    J Virol 67:4533-42. 1993
    ..helper T-cell determinants on viral proteins was analyzed with recombinant vaccinia viruses expressing Friend murine leukemia virus (F-MuLV) gag or env genes or shorter fragments of the env gene...
  35. pmc Inhibition of T7 and T3 RNA polymerase directed transcription elongation in vitro
    R F Rando
    Triplex Pharmaceutical Corporation, The Woodlands, TX 77380
    Nucleic Acids Res 22:678-85. 1994
    ..A 45 base-pair purine-rich region located within the gag gene of Friend Murine Leukemia Virus (FMLV) was used as the duplex target...
  36. ncbi Fre-2, a locus closely linked to Fv-2, is rearranged in some erythroleukemias induced by Friend murine leukemia virus
    D Eisel
    Institute of Medical Virology, Justus Liebig University, Giessen, Germany
    Leukemia 11:155-9. 1997
    b>Friend murine leukemia virus (F-MuLV) induces leukemia by integration into the cellular genome, thereby changing the structure of expression of cellular oncogenes...
  37. pmc Sequence flexibility in the polytropic env gp70-derived region of the membrane glycoprotein (gp55) of Friend spleen focus-forming virus affects its biological activity
    T Yugawa
    Laboratory of Gene Technology and Safety, Tsukuba Life Science Center, The Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    J Virol 72:2272-9. 1998
    ..Here we injected the F-SFFV(MS)-Friend murine leukemia virus (F-MuLV) clone 57 complex into newborn DBA/2 mice...
  38. pmc Characterization of a live-attenuated retroviral vaccine demonstrates protection via immune mechanisms
    U Dittmer
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 72:6554-8. 1998
    ..The results indicated that immune mechanisms rather than viral interference mediated protection...
  39. ncbi Genetic and immunological parameters governing in vivo susceptibility/resistance to retrovirally induced murine malignant histiocytosis
    A Panoskaltsis-Mortari
    Department of Pediatrics, University of Minnesota Hospital and Clinic, Minneapolis, USA
    J Leukoc Biol 64:441-50. 1998
    ....
  40. pmc Analysis of receptor usage by ecotropic murine retroviruses, using green fluorescent protein-tagged cationic amino acid transporters
    M Masuda
    Department of Microbiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Virol 73:8623-9. 1999
    ..The data also suggested that CAT proteins might be expressed in an oligomeric form. Further application of the system developed in this study may provide useful insights into the entry mechanism of ecotropic MuLV...
  41. ncbi Resistance to Friend leukemia virus in transgenic mice expressing the native Fv-4 gene
    M K Jackson
    Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322 5700, USA
    Acta Virol 43:19-23. 1999
    ..In both founder lines, there was no detectable expression of the transgene or resistance to Friend murine leukemia virus (FrMLV) in hemizygotes...
  42. pmc Resistance to Friend murine leukemia virus infection conferred by the Fv-4 gene is recessive but appears dominant from the effect of the immune system
    F Zhang
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Virol 74:6193-7. 2000
    Fv-4 is a mouse gene that dominantly confers resistance to infection with Friend murine leukemia virus (F-MuLV) (S. Suzuki, Jpn. J. Exp. Med. 45:473-478, 1975)...
  43. pmc Envelope proteins containing single amino acid substitutions support a structural model of the receptor-binding domain of bovine leukemia virus surface protein
    Elizabeth R Johnston
    Department of Animal Science and Graduate Group in Biochemistry and Molecular Biology, University of California, Davis, California 95616, USA
    J Virol 76:10861-72. 2002
    ..We modeled the BLV RBD by aligning putative structural elements with known elements of the ecotropic Friend murine leukemia virus RBD monomer. All the variant RBD residues but one are exposed on the surface of this BLV model...
  44. ncbi Neuropathology of experimental autoimmune encephalomyelitis modified by retroviral infection
    Hidefumi Fukumitsu
    Institute of Life Science, Soka University, Hachioji, Tokyo, Japan
    Neuropathology 22:280-9. 2002
    The A8 virus is a molecular clone of the neuropathogenic FrC6 virus derived from the Friend murine leukemia virus (F-MuLV)...
  45. ncbi Up-regulation of SLAP in FLI-1-transformed erythroblasts interferes with EpoR signaling
    Ingrid Lebigot
    Institut Curie, Bat 110, Centre Universitaire, 91405 Orsay, France
    Blood 102:4555-62. 2003
    Rearrangement of the FLI-1 locus and ensuing overexpression of FLI-1 protein is an early event in Friend murine leukemia virus (F-MuLV)-induced erythroleukemia...
  46. pmc Identification of a protective CD4+ T-cell epitope in p15gag of Friend murine leukemia virus and role of the MA protein targeting the plasma membrane in immunogenicity
    Daisuke Sugahara
    Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
    J Virol 78:6322-34. 2004
    ..We have previously demonstrated that immunization with Friend murine leukemia virus (F-MuLV) Gag proteins protects mice against the fatal Friend retrovirus (FV) infection...
  47. pmc Novel host range and cytopathic variant of ecotropic Friend murine leukemia virus
    Yong Tae Jung
    Labotratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases NIH, Bldg 4, Room 329, 4 Center Drive, MSC 0460, Bethesda, MD 20892 0460, USA
    J Virol 78:12189-97. 2004
    A variant ecotropic Friend murine leukemia virus, F-S MLV, is capable of inducing the formation of large multinucleated syncytia in Mus dunni cells...
  48. ncbi Direct transcriptional regulation of MDM2 by Fli-1
    Amandine H L Truong
    Department of Medical Biophysics, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario, Canada M4N 3M5
    Oncogene 24:962-9. 2005
    ..transcription factor, Fli-1, has been shown to play a pivotal role in the induction and progression of Friend Murine Leukemia Virus (F-MuLV)-induced erythroleukemia, with its overexpression leading to erythroblast survival, ..
  49. pmc The splenic microenvironment is a source of proangiogenesis/inflammatory mediators accelerating the expansion of murine erythroleukemic cells
    Yuval Shaked
    Department of Molecular and Cellular Biology, Sunnybrook and Women s College Health Sciences Centre, Toronto, ON, Canada
    Blood 105:4500-7. 2005
    ..Here we have used Friend murine leukemia virus (F-MuLV)-induced erythroleukemia to investigate factors of the splenic microenvironment that may make ..
  50. ncbi Increased expression of c-myc is associated with thymoma in rats infected with murine leukemia virus A8
    Tomoko Hirano
    Department of Bioinformatics, Faculty of Engineering, Soka University, Hachioji, Tokyo 192 8577, Japan
    Microbiol Immunol 49:1069-74. 2005
    Infection of rats with Friend murine leukemia virus (Fr-MLV) clone A8 causes thymoma in all the animals within 7 weeks. The rapid induction of thymoma is associated with a unique enhancer structure in the U3 region of the A8-LTR...
  51. ncbi Analysis of the distribution of neuropathogenic retroviral antigens following PVC211 or A8-V infection
    Ryuhei Nakai
    Department of Geriatric Medicine, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611 Japan
    Microbiol Immunol 49:1075-81. 2005
    A8-V and PVC211 are neuropathogenic strains of the Friend murine leukemia virus (Fr-MLV) that cause spongiosis in the rat brain after infection at birth...
  52. pmc Importance of receptor usage, Fli1 activation, and mouse strain for the stem cell specificity of 10A1 murine leukemia virus leukemogenicity
    Michaela Rodenburg
    Heinrich Pette Institut, Hamburg, Germany
    J Virol 81:732-42. 2007
    ..In summary, we validate the significance of the env gene in leukemia specificity and underline the importance of a complex interplay of cooperating oncogenes and/or tumor suppressors in determining the pathogenicity of MuLV variants...
  53. ncbi Retroviral insertional activation of the Fli-3 locus in erythroleukemias encoding a cluster of microRNAs that convert Epo-induced differentiation to proliferation
    Jiu Wei Cui
    Department of Molecular and Cellular Biology, Sunnybrook Health Sciences Center, Toronto, ON, Canada
    Blood 110:2631-40. 2007
    ..Using this model, we have isolated a novel integration site designated Fli-3, from a Friend murine leukemia virus (F-MuLV)-induced erythroleukemia...
  54. ncbi Evaluation of the Friend Virus model for the development of improved adenovirus-vectored anti-retroviral vaccination strategies
    Wibke Bayer
    Ruhr University Bochum, Institute of Microbiology and Hygiene, Department of Molecular and Medical Virology, Building MA, Room 6 40, D 44801 Bochum, Germany
    Vaccine 26:716-26. 2008
    ..Our results suggest that the FV model can provide insight into the development of improved adenovirus vectors for HIV-1 vaccination...
  55. doi Friend murine leukemia virus A8 regulates Env protein expression through an intron sequence
    Naoki Yamamoto
    Department of Bioinformatics, Soka University, Tokyo, Japan
    Virology 385:115-25. 2009
    b>Friend murine leukemia virus (Fr-MLV) produces unspliced mRNAs, as well as singly-spliced mRNAs by which the Env protein is generated...
  56. doi Insertional activation of myb by F-MuLV in SCID mice induces myeloid leukemia
    Mehran Haeri
    Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Int J Oncol 43:169-76. 2013
    ..This approach led to the discovery of the Friend murine leukemia virus (F-MuLV) integration site-1 (fli-1)...
  57. doi Kinetic studies of the effect of a 17-nucleotide difference in the 0.3-kb region containing the R-U5-5' leader sequence of Friend murine leukemia virus on viral gene expression
    Yeng Cheng Choo
    Department of Bioinformatics, Faculty of Engineering, Soka University, 1 236, Tangi machi, Hachioji shi, Tokyo, 192 8577, Japan
    Microbiol Immunol 57:594-9. 2013
    ..the R-U5-5' leader sequence is essential for the induction of spongiform neurodegeneration by Friend murine leukemia virus (Fr-MLV) clone A8 and it also influences expression of the Env protein...
  58. pmc Retrovirus glycoprotein functionality requires proper alignment of the ectodomain and the membrane-proximal cytoplasmic tail
    Sanath Kumar Janaka
    Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, Missouri, USA
    J Virol 87:12805-13. 2013
    Nonnative viral glycoproteins, including Friend murine leukemia virus envelope (F-MLV Env) are actively recruited to HIV-1 assembly sites by an unknown mechanism...
  59. pmc Retroviral integration within the Fli-2 locus results in inactivation of the erythroid transcription factor NF-E2 in Friend erythroleukemias: evidence that NF-E2 is essential for globin expression
    S J Lu
    Cancer Research Division, Sunnybrook Health Science Centre, Toronto, ON Canada
    Proc Natl Acad Sci U S A 91:8398-402. 1994
    ..designated Fli-2 (Friend leukemia integration 2), in some erythroleukemia clones induced either by Friend murine leukemia virus (F-MuLV) or by the polycythemia-inducing strain of Friend virus complex (FV-P)...
  60. ncbi Expression of a tolerizing tumor antigen in peripheral tissue does not preclude recovery of high-affinity CD8+ T cells or CTL immunotherapy of tumors expressing the antigen
    C Ohlen
    Department of Immunology and Division of Oncology, University of Washington, Seattle, WA 98195, USA
    J Immunol 166:2863-70. 2001
    Transgenic (TG) mice were generated selectively expressing the gag protein of Friend murine leukemia virus (FMuLV) in the liver...
  61. pmc Bovine leukemia virus SU protein interacts with zinc, and mutations within two interacting regions differently affect viral fusion and infectivity in vivo
    Jean Stéphane Gatot
    Unité de Biologie Cellulaire et Moléculaire, Faculté universitaire des Sciences agronomiques, Gembloux, Belgium
    J Virol 76:7956-67. 2002
    ..Interestingly, zinc ions were found to be associated with the receptor-binding domain (RBD) of Friend murine leukemia virus (Fr-MLV) SU glycoprotein, further supporting their relevance in SU structure...
  62. pmc Complete nucleotide sequence of Friend murine leukemia virus, strain FB29
    S Perryman
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840
    Nucleic Acids Res 19:6950. 1991
  63. ncbi Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21
    D S Threadgill
    Department of Veterinary Pathology, Texas A and M University, College Station 77843
    Genomics 11:1143-8. 1991
    ..FIM3, SI, and CP mapped to bovine syntenic group U10, while RAF1 and GPX1 mapped to U12...
  64. pmc Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas
    D Bergeron
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Canada
    J Virol 65:7-15. 1991
    ..Restriction map analysis shows that this region is identical to the Fli-1 locus identified in Friend murine leukemia virus-induced erythroleukemia cell lines and thus may contain sequences also responsible for the development ..
  65. ncbi Detection of burst-promoting activity in spleens of myeloproliferative sarcoma virus-infected mice using serum-free cultures
    K Matsuo
    Department of Pathology, Faculty of Medicine, University of Tokyo, Japan
    Acta Pathol Jpn 41:259-64. 1991
    ..was induced in adult DBA/2 mice by inoculation with myeloproliferative sarcoma virus (MPSV) and Friend murine leukemia virus (F-MuLV) as a helper virus. On day 26 after infection, the spleen weighed a maximum of 2...
  66. pmc Conversion of Friend mink cell focus-forming virus to Friend spleen focus-forming virus by modification of the 3' half of the env gene
    N Watanabe
    Laboratory of Gene Technology and Safety, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    J Virol 65:132-7. 1991
    ..However, when this virus pseudotyped by Friend murine leukemia virus was passaged in newborn DBA/2 mice, we could recover weakly pathogenic viruses with a high frequency...
  67. pmc The R-U5-5' leader sequence of neurovirulent wild mouse retrovirus contains an element controlling the incubation period of neurodegenerative disease
    J L Portis
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
    J Virol 65:1877-83. 1991
    ..showed that introduction of long terminal repeat (LTR) and gag-pol sequences from a strain of Friend murine leukemia virus (FB29) resulted in a dramatic acceleration of the onset of the disease...
  68. ncbi Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1
    Y Ben-David
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Genes Dev 5:908-18. 1991
    The retroviral integration site Fli-1 is rearranged in 75% of the erythroleukemia cell clones induced by Friend murine leukemia virus (F-MuLV), whereas Spi-1/PU...
  69. ncbi Alternative splicing of the Evi-1 zinc finger gene generates mRNAs which differ by the number of zinc finger motifs
    D Bordereaux
    Laboratoire Immunologie et Oncologie des Maladies Rétrovirales, INSERM U152, Hopital Cochin, Paris, France
    Oncogene 5:925-7. 1990
    ..This was confirmed by Northern blot analysis and S1 mapping experiments. Therefore, the Evi-1 gene codes potentially for at least two proteins of 1042 and 718 amino acids differing in the numbers of their zinc-finger motifs...
  70. ncbi Ras p21 onco-protein in the sera of mice carrying an experimentally induced tumor and in human cancer patients
    A Kakkanas
    Hellenic Pasteur Institute, Athens, Greece
    In Vivo 4:115-20. 1990
    ..by a mouse cell line transformed with the Harvey murine sarcoma virus in the presence of a helper Friend murine leukemia virus. As determined by ELISA and immunoblot assays, ras p21 in the serum increased with increased tumor ..
  71. ncbi A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
    M Souyri
    INSERM U 152 Hôpital Cochin, Paris, France
    Cell 63:1137-47. 1990
    ..clone, we found that this region comprises a novel oncogene named v-mpl in phase with two parts of the Friend murine leukemia virus envelope gene...
  72. pmc Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus
    Y Ben-David
    Division of Molecular and Developmental Biology, Mount Sinai Hospital Research Institute, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 87:1332-6. 1990
    b>Friend murine leukemia virus (F-MuLV) induces erythroleukemia when inoculated into newborn BALB/c or NIH/Swiss mice...
  73. ncbi Significant differences in therapeutic responses to a human interferon-alpha B/D hybrid in Rauscher or Friend murine leukemia virus infections
    J D Gangemi
    Research Laboratories, Pharmaceuticals Division, Ciba Geigy Ltd, Basel, Switzerland
    J Interferon Res 9:275-83. 1989
    ....
  74. ncbi The spleen focus-forming virus envelope glycoprotein is defective in oligomerization
    D R Kilpatrick
    Department of Microbiology, University of Alabama, Birmingham 35294
    J Biol Chem 264:10732-7. 1989
    ..glycoprotein of Friend spleen focus-forming virus (SFFV) is a recombinant molecule derived from Friend murine leukemia virus (MuLV) by various deletions, insertions, and substitutions...
  75. pmc Intracellular transport and leukemogenicity of spleen focus-forming virus envelope glycoproteins with altered transmembrane domains
    R V Srinivas
    Department of Microbiology, University of Alabama, Birmingham 35294
    J Virol 61:4007-11. 1987
    ..derived from the SFFV envelope gene and membrane-spanning and cytoplasmic domains derived from the Friend murine leukemia virus envelope gene...
  76. pmc Frequent involvement of the fim-3 region in Friend murine leukemia virus-induced mouse myeloblastic leukemias
    D Bordereaux
    Laboratoire Immunologie et Virologie des Tumeurs, Institut National de la Sante et de la Recherche Medicale, Paris, France
    J Virol 61:4043-5. 1987
    fim-3 is a new proviral integration region involved in 23% (16 of 68) of Friend murine leukemia virus-induced myeloblastic leukemias. This region is distinct from 20 oncogenes and from putative oncogenes tested so far...
  77. pmc Loss of pathogenicity of spleen focus-forming virus after pseudotyping with Akv
    K S Jones
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
    J Virol 62:511-8. 1988
    Friend virus complex (FV), which comprises replication-competent Friend murine leukemia virus (FMuLV) plus replication-defective spleen focus-forming virus (SFFV), induces a multistage erythroleukemia...
  78. ncbi Substitution of the LTR of Abelson murine leukemia virus does not alter the cell type of virally induced tumors
    P L Green
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Oncogene 2:585-92. 1988
    ..Also, our results suggest that a threshold amount of the v-abl protein product is necessary for in vitro transformation, and this level of expression may be different from the level selected during in vivo tumorigenesis...
  79. pmc Fim-1, Fim-2/c-fms, and Fim-3, three common integration sites of Friend murine leukemia virus in myeloblastic leukemias, map to mouse chromosomes 13, 18, and 3, respectively
    B Sola
    Institut National de la Santé et de la Recherche Médicale U152 Centre National de la Recherche Scientifique, UA628, Hopital Cochin, Paris, France
    J Virol 62:3973-8. 1988
    ..sites, Fim-1, Fim-2/c-fms, and Fim-3, have been described in mouse myeloid leukemias induced by the Friend murine leukemia virus. The nature and function of Fim-1 and Fim-3 are still unknown since no transcript from these loci has ..
  80. ncbi The human homologues of Fim1, Fim2/c-Fms, and Fim3, three retroviral integration regions involved in mouse myeloblastic leukemias, are respectively located on chromosomes 6p23, 5q33, and 3q27
    N Van Cong
    Clinique et Unité de Recherches de Génétique Médicale INSERM U 12, Hopital des Enfants Malades, Paris, France
    Hum Genet 81:257-63. 1989
    ..involved in the early stages of myeloblastic leukemogenesis induced in vivo or in vitro by the Friend murine leukemia virus. Fim2 was identified as the 5' end of the c-Fms protooncogene, which encodes the receptor of the ..
  81. ncbi Hemolytic anemia and erythroleukemia, two distinct pathogenic effects of Friend MuLV: mapping of the effects to different regions of the viral genome
    M Sitbon
    Cell 47:851-9. 1986
    ..Moreover, the ability of the virus to induce rapid erythroleukemia appeared to be independent of the presence of severe early hemolytic anemia...
  82. pmc Isolation of new oncogenic forms of the murine c-fms gene
    N de Parseval
    Hopital Cochin, Institut Cochin de Genetique Moleculaire, U 363 Institut National de la Santé et de la Recherche Médicale, Universite Paris V, France
    J Virol 69:3597-604. 1995
    ..a Harvey sarcoma virus-derived retroviral vector containing the murine c-fms cDNA was pseudotyped with Friend murine leukemia virus and inoculated into newborn DBA/2 mice...
  83. pmc A constitutively activated erythropoietin receptor stimulates proliferation and contributes to transformation of multipotent, committed nonerythroid and erythroid progenitor cells
    G D Longmore
    Department of Medicine, Washington University, St Louis, Missouri 63110
    Mol Cell Biol 14:2266-77. 1994
    ..provirus upstream of the fli-1 gene, in a location typically seen in erythroleukemic cells generated by Friend murine leukemia virus infection. This event led to increased expression of fli-1 in this cell line...
  84. pmc Increased hematopoiesis in mice soon after infection by Friend murine leukemia virus
    T Mitchell
    McArdle Laboratory for Cancer Research, University of Wisconsin Madison 53706
    J Virol 67:3665-70. 1993
    b>Friend murine leukemia virus (F-MuLV), an erythroleukemogenic replication-competent retrovirus, induces leukemia in its host after a long latency...
  85. ncbi The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members
    L Zhang
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Oncogene 8:1621-30. 1993
    ..induced by either the replication-defective Friend spleen focus-forming virus (SFFV) or the Friend murine leukemia virus (F-MuLV) are associated with the insertional activation of one of two members (Spi-1 or Fli-1) of the ..
  86. ncbi Activity of Friend mink cell focus-forming retrovirus during myelo-erythroid hematopoiesis
    C Baum
    , , Germany
    Exp Hematol 24:364-70. 1996
    Friend mink cell focus-forming (FMCF) viruses are recombinants between the Friend murine leukemia virus (F-MuLV) and endogenous polytropic retroviruses involved in a number of retrovirus-induced malignancies of the myelo-erythroid ..
  87. pmc Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia
    F Melet
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 16:2708-18. 1996
    ..Homozygous mutant mice remained susceptible to erythroleukemia induction by Friend murine leukemia virus, although the latency period was significantly increased...
  88. pmc Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors
    W Chen
    Division of Oncology, Department of Medicine, University of Washington, Seattle 98195, USA
    J Virol 70:7773-82. 1996
    FBL-3 is a highly immunogenic murine leukemia of C57BL/6 origin induced by Friend murine leukemia virus (MuLV)...
  89. pmc Analysis of the unique hamster cell tropism of ecotropic murine leukemia virus PVC-211
    M Masuda
    Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21702 1201, USA
    J Virol 70:8534-9. 1996
    ..Further studies on the interaction between PVC-211 MuLV and the receptor on hamster cells may provide novel insights into the molecular mechanisms for receptor recognition and binding by viral envelope glycoproteins...
  90. pmc Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brains
    W P Lynch
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 70:8896-907. 1996
    ..CasE expression in these cells resulted in complete (>10(5)) interference of superinfection with Friend murine leukemia virus clone FB29, whereas CasES expression resulted in a 1.8-log-unit decrease in FB29 titer...
  91. pmc Susceptibility of nude mice carrying the Fv-4 gene to Friend murine leukemia virus infection
    K Higo
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Japan
    J Virol 71:750-4. 1997
    Fv-4 is a mouse gene that dominantly confers resistance to infection with Friend murine leukemia virus (F-MuLV) (S. Suzuki, Jpn. J. Exp. Med. 45:473-478, 1975)...
  92. ncbi Fre2, a proviral integration site of Friend murine leukemia virus that is closely linked to Fv2
    R W Friedrich
    Institute of Medical Virology, Justus Liebig University, Giessen, Germany
    Leukemia 11:619-23. 1997
    b>Friend murine leukemia virus (F-MuLV) induces leukemia by integration into the cellular genome, thereby changing the structure or expression of cellular oncogenes...
  93. ncbi Pathogenesis of Friend leukemia virus
    Y Ikawa
    Department of Retroviral Regulation, Tokyo Medical and Dental University Medical Research Division, Japan
    Leukemia 11:152-4. 1997
    ..of replication-defective, Friend spleen focus-forming virus (F-SFFV) and replication-competent, Friend murine leukemia virus (F-MuLV)...
  94. ncbi Unique sequence and lesional tropism of a new variant of neuropathogenic friend murine leukemia virus
    S Takase-Yoden
    Institute of Life Science, Soka University, Hachioji, Tokyo, Japan
    Virology 233:411-22. 1997
    ..These sequences in A8 and PVC211 were compared, focusing in on the sites that account for neurovirulence and viral lesional tropism...
  95. ncbi Abnormal erythropoietin (Epo) gene expression in the murine erythroleukemia IW32 cells results from a rearrangement between the G-protein beta2 subunit gene and the Epo gene
    S Chretien
    Institut National de la Transfusion Sanguine, Paris, France
    Oncogene 15:1995-9. 1997
    ..This resulting abnormal cDNA allows the expression of a normal Epo protein...
  96. ncbi Phylogenetic relationship of the complete Rauscher murine leukemia virus genome with other murine leukemia virus genomes
    A H Khimani
    Laboratory of Viral Pathogenesis, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Virology 238:64-7. 1997
    ..In summary, a phylogenetic analysis involving various MuLVs has been performed, in which the postulated close relationship between R-MuLV and F-MuLV has been confirmed, consistent with the pathobiology of the two viruses...
  97. pmc Identification of genetic determinants responsible for the rapid immunosuppressive activity and the low leukemogenic potential of a variant of Friend leukemia virus, FIS-2
    H Y Dai
    UNIGEN Center for Molecular Biology, Norwegian University of Science and Technology, Trondheim
    J Virol 72:1244-51. 1998
    An immunosuppressive variant of Friend murine leukemia virus (F-MuLV), FIS-2, induces suppression of the primary antibody response against sheep erythrocytes (SRBC) in adult NMRI mice more efficiently than the prototype F-MuLV clone 57 (..
  98. pmc Brain infection by neuroinvasive but avirulent murine oncornaviruses
    S Askovic
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840, USA
    J Virol 74:465-73. 2000
    ..from the wild mouse virus CasBrE into the genome of a neuroinvasive but nonneurovirulent strain of Friend murine leukemia virus (FMuLV), FB29...
  99. ncbi Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos
    L A Brown
    Developmental Biology Research Centre, Randall Institute, King s College London, 26 29 Drury Lane, London, UK
    Mech Dev 90:237-52. 2000
    ..The phenotype of sonic-you mutants implies a likely role for Sonic Hedgehog in mediating these processes...
  100. ncbi Induction of protective immunity against pathogenic simian immunodeficiency virus by a foreign receptor-dependent replication of an engineered avirulent virus
    T Matano
    AIDS Research Center, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, 208 0011, Tokyo, Japan
    Vaccine 18:3310-8. 2000
    ..We generated a chimeric SIV, FMSIV, by replacing SIV env with ecotropic Friend murine leukemia virus (FMLV) env to confine its replication to FMLV receptor (mCAT1)-expressing cells...
  101. ncbi Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia
    A Hart
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Immunity 13:167-77. 2000
    The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli-1 locus die at day 11...

Research Grants8

  1. JAQUELIN PAGE DUDLEY; Fiscal Year: 2014
    ..Mtv-null mice are more resistant to specific viral and bacterial pathogens, including exogenous MMTV, Friend murine leukemia virus, and the gram- negative bacterium, Vibrio cholerae, compared to the parental BALB/c strain...
  2. Nanoparticle Analysis of Enveloped Virus Entry Pathways
    Robert Davey; Fiscal Year: 2009
    ..In this proposal, we will optimize techniques to construct fluorescent NPs coated in the envs of Friend murine leukemia virus, Venezuelan equine encephalitis virus (NIH category B agent) and Ebola (NIH category An agent)...
  3. Receptor Trafficking in Entry of Murine Leukemia Viruses
    Robert A Davey; Fiscal Year: 2011
    ..We compared infection of Friend murine leukemia virus (Fr-MLV) to Vesicular stomatitis virus, Venezuelan equine encephalitis virus and Ebola using an ..
  4. WALTHER H MOTHES; Fiscal Year: 2016
    ..to the understanding of the biogenesis of virological synapses using a model retrovirus, the Friend murine leukemia virus (F-MLV)...
  5. MOLECULAR ENGINEERING OF RETROVIRAL VACCINES
    Edward Stephens; Fiscal Year: 1990
    The Friend murine leukemia virus (F-MuLV) is a replication competent retrovirus that is capable of causing erythroleukemia in newborn mice and can induce acute erythroleukemia in adult mice in association with replication defective spleen ..
  6. Role of the STK Receptor in Erythropoiesis
    Pamela Hankey; Fiscal Year: 2009
    ....
  7. FUNCTIONAL ROLE OF FLI-1 IN NEOPLASIA
    E Reddy; Fiscal Year: 2000
    Mouse Fli-1 gene is shown to be rearranged in 75% of erythroleukemias induced by Friend murine leukemia virus. We have cloned and characterized the human Fli-1 gene...
  8. MURINE STK RECEPTOR AND MACROPHAGE ACTIVATION
    PAMELA CORRELL; Fiscal Year: 2002
    ..By understanding, in more detail, the regulation of macrophage activation, the PI hopes to begin to identify targets for suppression of the tissue-damaging effects of inflammation without compromising the host immune response. ..

Patents5

  1. Viral nucleic acid microarray and method of use
    Patent Number: WO2007130519-A2; Date:2007-11-15
  2. Viral vectors comprising a nucleic sequence derived from murine leukemia viruses for gene transfer in cells
    Patent Number: WO03085117-A1; Date:2003-10-16
  3. RETROVIRAL VECTOR FOR THE TRANSFER AND EXPRESSION OF GENES FOR THERAPEUTICAL PURPOSES IN EUCARYOTIC CELLS
    Patent Number: WO9501447-A1; Date:1995-01-12
  4. Retroviral vector particles and methods for their generation and use
    Patent Number: EP2325322-A1; Date:2011-05-25
  5. RETROVIRAL VECTOR PARTICLES AND METHODS FOR THEIR GENERATION AND USE
    Patent Number: WO2011061336-A1; Date:2011-05-26