African swine fever virus

Summary

Alias: African swine fever virus ASF, African swine fever virus ASFV, African swine fever virus, ASFV, ASFV

Top Publications

  1. ncbi Effects of chlorine, iodine, and quaternary ammonium compound disinfectants on several exotic disease viruses
    J Shirai
    Department of Exotic Diseases, National Institute of Animal Health, Kodaira, Tokyo, Japan
    J Vet Med Sci 62:85-92. 2000
  2. pmc Novel swine virulence determinant in the left variable region of the African swine fever virus genome
    J G Neilan
    Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Greenport, New York 11944 0848, USA
    J Virol 76:3095-104. 2002
  3. ncbi Tick-borne viruses
    M Labuda
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovakia
    Parasitology 129:S221-45. 2004
  4. pmc The African swine fever virus thymidine kinase gene is required for efficient replication in swine macrophages and for virulence in swine
    D M Moore
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944 0848, USA
    J Virol 72:10310-5. 1998
  5. ncbi Continuous porcine cell lines developed from alveolar macrophages: partial characterization and virus susceptibility
    H M Weingartl
    NCFAD, CFIA, 1015 Arlington St, Winnipeg, MB, Canada R3E 3M4
    J Virol Methods 104:203-16. 2002
  6. doi Vaccination with viral protein-mimicking peptides postpones mortality in domestic pigs infected by African swine fever virus
    Vadim Ivanov
    Dr Rath Research Institute BV, 1260 Memorex Drive, Santa Clara, CA 95050, USA
    Mol Med Rep 4:395-401. 2011
  7. ncbi Evidence for the evolution of ascoviruses from iridoviruses
    Karine Stasiak
    Universite Francois Rabelais, UFR des Sciences et Techniques, Laboratoire d Etude des Parasites Génétiques, FRE CNRS 2535, Parc Grandmont, 37200 Tours, France
    J Gen Virol 84:2999-3009. 2003
  8. ncbi Development of a novel hot-start multiplex PCR for simultaneous detection of classical swine fever virus, African swine fever virus, porcine circovirus type 2, porcine reproductive and respiratory syndrome virus and porcine parvovirus
    Monica Giammarioli
    Perugia, 06126, Italy
    Vet Res Commun 32:255-62. 2008
  9. ncbi Detection of porcine teschoviruses and enteroviruses by LightCycler real-time PCR
    Andi Krumbholz
    Institut für Virologie und Antivirale Therapie, Klinikum der Friedrich Schiller Universität, Winzerlaer Str 10, Jena 07745, Germany
    J Virol Methods 113:51-63. 2003
  10. pmc African swine fever virus multigene family 360 and 530 genes affect host interferon response
    C L Afonso
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944, USA
    J Virol 78:1858-64. 2004

Research Grants

  1. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 2009
  2. W M BUJALOWSKI; Fiscal Year: 2016
  3. Dynamic of Retroviruses Assembly and Budding
    NOLWENN MONIQUE JOUVENET; Fiscal Year: 2010
  4. XIV International Poxvirus/Iridovirus Workshop
    EDWARD NILES; Fiscal Year: 2002
  5. Structure-Function Relationship of DNA Polymerases
    Ming Daw Tsai; Fiscal Year: 2006

Patents

  1. Enzymatic synthesis of L-nucleic acids
  2. Enzymatic synthesis of L-nucleic acids
  3. CD2 DEFICIENT AFRICAN SWINE FEVER VIRUS AS LIVE ATTENUATED OR SUBSEQUENTLY INACTIVATED VACCINE AGAINST AFRICAN SWINE FEVER IN MAMMALS
  4. Viral nucleic acid microarray and method of use

Detail Information

Publications231 found, 100 shown here

  1. ncbi Effects of chlorine, iodine, and quaternary ammonium compound disinfectants on several exotic disease viruses
    J Shirai
    Department of Exotic Diseases, National Institute of Animal Health, Kodaira, Tokyo, Japan
    J Vet Med Sci 62:85-92. 2000
    ..The viruses used were four enveloped viruses (vesicular stomatitis virus, African swine fever virus, equine viral arteritis virus, and porcine reproductive and respiratory syndrome virus) and two non-..
  2. pmc Novel swine virulence determinant in the left variable region of the African swine fever virus genome
    J G Neilan
    Plum Island Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Greenport, New York 11944 0848, USA
    J Virol 76:3095-104. 2002
    Previously we have shown that the African swine fever virus (ASFV) NL gene deletion mutant E70DeltaNL is attenuated in pigs...
  3. ncbi Tick-borne viruses
    M Labuda
    Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovakia
    Parasitology 129:S221-45. 2004
    ..With only one exception (African swine fever virus, family Asfarviridae) all tick-borne viruses (as well as all other arboviruses) are RNA viruses...
  4. pmc The African swine fever virus thymidine kinase gene is required for efficient replication in swine macrophages and for virulence in swine
    D M Moore
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944 0848, USA
    J Virol 72:10310-5. 1998
    b>African swine fever virus (ASFV) replicates in the cytoplasm of infected cells and contains genes encoding a number of enzymes needed for DNA synthesis, including a thymidine kinase (TK) gene...
  5. ncbi Continuous porcine cell lines developed from alveolar macrophages: partial characterization and virus susceptibility
    H M Weingartl
    NCFAD, CFIA, 1015 Arlington St, Winnipeg, MB, Canada R3E 3M4
    J Virol Methods 104:203-16. 2002
    ..virus (PRV), classical swine fever virus (CSFV), swine vesicular disease virus (SVDV), swine poxvirus, African swine fever virus (ASFV), herpes simplex virus (HSV), parainfluenza virus, bovine adenovirus (BAV), vaccinia virus (VV), ..
  6. doi Vaccination with viral protein-mimicking peptides postpones mortality in domestic pigs infected by African swine fever virus
    Vadim Ivanov
    Dr Rath Research Institute BV, 1260 Memorex Drive, Santa Clara, CA 95050, USA
    Mol Med Rep 4:395-401. 2011
    Periodic outbreaks of African swine fever virus (ASFV) infection around the world threaten local populations of domestic pigs with lethal disease and provide grounds for pandemic spread...
  7. ncbi Evidence for the evolution of ascoviruses from iridoviruses
    Karine Stasiak
    Universite Francois Rabelais, UFR des Sciences et Techniques, Laboratoire d Etude des Parasites Génétiques, FRE CNRS 2535, Parc Grandmont, 37200 Tours, France
    J Gen Virol 84:2999-3009. 2003
    ..viruses (family Phycodnaviridae), vertebrate and invertebrate iridoviruses (family Iridoviridae) and African swine fever virus (ASFV; family Asfarviridae) showed that ascovirus proteins clustered most closely with those of the ..
  8. ncbi Development of a novel hot-start multiplex PCR for simultaneous detection of classical swine fever virus, African swine fever virus, porcine circovirus type 2, porcine reproductive and respiratory syndrome virus and porcine parvovirus
    Monica Giammarioli
    Perugia, 06126, Italy
    Vet Res Commun 32:255-62. 2008
    ..Specific primers for each of five virus genomes, namely classical swine fever virus (CSFV), African swine fever virus (ASFV), porcine circovirus type 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV) ..
  9. ncbi Detection of porcine teschoviruses and enteroviruses by LightCycler real-time PCR
    Andi Krumbholz
    Institut für Virologie und Antivirale Therapie, Klinikum der Friedrich Schiller Universität, Winzerlaer Str 10, Jena 07745, Germany
    J Virol Methods 113:51-63. 2003
    ..Other viruses such as classical swine fever virus (CSFV), African swine fever virus, pseudorabies virus (PRV), vesicular stomatitis virus, vesicular exanthema virus, porcine respiratory ..
  10. pmc African swine fever virus multigene family 360 and 530 genes affect host interferon response
    C L Afonso
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944, USA
    J Virol 78:1858-64. 2004
    b>African swine fever virus (ASFV) multigene family 360 and 530 (MGF360/530) genes affect viral growth in macrophage cell cultures and virulence in pigs (L. Zsak, Z. Lu, T. G. Burrage, J. G. Neilan, G. F. Kutish, D. M. Moore, and D. L...
  11. ncbi Evolution of viral DNA-dependent DNA polymerases
    C W Knopf
    Forschungsschwerpunkt Genomforschung und Bioinformatik, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Virus Genes 16:47-58. 1998
    ..Due to a lower branch integrity Pol of T-even bacteriophages, poxviruses, African swine fever virus, fish herpesvirus, and baculoviruses were not clearly resolved and placed in alternate groupings...
  12. pmc Regulation of host translational machinery by African swine fever virus
    Alfredo Castello
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    PLoS Pathog 5:e1000562. 2009
    b>African swine fever virus (ASFV), like other complex DNA viruses, deploys a variety of strategies to evade the host's defence systems, such as inflammatory and immune responses and cell death...
  13. doi Design and verification of a highly reliable Linear-After-The-Exponential PCR (LATE-PCR) assay for the detection of African swine fever virus
    B Ronish
    Department of Biology, Brandeis University, Waltham, MA 02454 9110, USA
    J Virol Methods 172:8-15. 2011
    b>African swine fever virus (ASFV) is a highly pathogenic DNA virus that is the causative agent of African swine fever (ASF), an infectious disease of domestic and wild pigs of all breeds and ages, causing a range of syndromes...
  14. doi Pathogenicity of endophytic entomopathogenic fungi to Ornithodoros erraticus and Ornithodoros moubata (Acari: Argasidae)
    Iñigo Zabalgogeazcoa
    Instituto de Recursos Naturales y Agrobiología IRNASA, CSIC, Cordel de Merinas, 40 52, 37008 Salamanca, Spain
    Vet Parasitol 158:336-43. 2008
    ..erraticus and O. moubata are of great medical and veterinary importance because they are vectors of the African swine fever virus and several species of human relapsing fever borreliae...
  15. doi Assessing the impact of climate change on vector-borne viruses in the EU through the elicitation of expert opinion
    P Gale
    Centre for Epidemiology and Risk Analysis, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, UK
    Epidemiol Infect 138:214-25. 2010
    ..fever virus (CCHFV) and Rift Valley fever virus (RVFV) into the EU from other parts of the world, with African swine fever virus (ASFV) and West Nile virus (WNV) being less affected...
  16. pmc An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine
    T Lewis
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Greenport, New York 11944 0848, USA
    J Virol 74:1275-85. 2000
    The African swine fever virus (ASFV) genome contains a gene, 9GL, with similarity to yeast ERV1 and ALR genes. ERV1 has been shown to function in oxidative phosphorylation and in cell growth, while ALR has hepatotrophic activity...
  17. ncbi Expression of ubiquitin, actin, and actin-like genes in African swine fever virus infected cells
    C Ferreira
    Gulbenkian Institute of Science, Oeiras, Portugal
    Virus Res 44:11-21. 1996
    ..to study the accumulation of specific cellular mRNAs (ubiquitin and actin) in Vero cells infected with African swine fever virus (ASFV). ASFV modulates the cytoplasmic levels of ubiquitin and actin mRNAs throughout infection...
  18. ncbi Sequences and replication of genomes of the archaeal rudiviruses SIRV1 and SIRV2: relationships to the archaeal lipothrixvirus SIFV and some eukaryal viruses
    X Peng
    Microbial Genome Centre, Institute of Molecular Biology, Copenhagen University, Sølvgade 83H, DK 1307 Copenhagen K, Denmark
    Virology 291:226-34. 2001
    ..replicate by the same mechanism as the similarly organized linear genomes of the eukaryal poxviruses, African swine fever virus and Chlorella viruses...
  19. pmc Processing and localization of the african swine fever virus CD2v transmembrane protein
    Lynnette C Goatley
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol 85:3294-305. 2011
    The African swine fever virus (ASFV)-encoded CD2v transmembrane protein is required for the hemadsorption of red blood cells around infected cells and is also required for the inhibition of bystander lymphocyte proliferation in response ..
  20. ncbi Molecular monitoring of African swine fever virus using surveys targeted at adult ornithodoros ticks: a re-evaluation of Mkuze game reserve, South Africa
    L F Arnot
    Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, 0002 South Africa
    Onderstepoort J Vet Res 76:385-92. 2009
    The Mkuze Game Reserve (MGR), in north-eastern KwaZulu-Natal Province, South Africa is an African swine fever virus (ASF) controlled area...
  21. ncbi Interactions of the DNA polymerase X of African swine fever virus with double-stranded DNA. Functional structure of the complex
    Maria J Jezewska
    Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology, The University of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555 1053, USA
    J Mol Biol 373:75-95. 2007
    Interactions of the polymerase X of African swine fever virus with the double-stranded DNA (dsDNA) have been studied with fluorescent dsDNA oligomers, using quantitative fluorescence titrations, analytical ultracentrifugation, and ..
  22. pmc Mismatched base-pair simulations for ASFV Pol X/DNA complexes help interpret frequent G*G misincorporation
    Benedetta A Sampoli Benitez
    Department of Natural Sciences and Mathematics, Marymount Manhattan College, 221 East 71st Street, New York, NY 10021, USA
    J Mol Biol 384:1086-97. 2008
    DNA polymerase X (pol X) from the African swine fever virus is a 174-amino-acid repair polymerase that likely participates in a viral base excision repair mechanism, characterized by low fidelity...
  23. ncbi Viruses in boar semen: detection and clinical as well as epidemiological consequences regarding disease transmission by artificial insemination
    B Guerin
    Laboratoire National pour le Contrôle des Reproducteurs, 94703 Maisons Alfort, France
    Theriogenology 63:556-72. 2005
    ..picornaviruses, adenoviruses, enteroviruses, Japanese encephalitis virus, pseudorabies virus, African swine fever virus and reoviruses are of particular importance and accurate monitoring prior to and during the presence of ..
  24. ncbi The cellular immune recognition of proteins expressed by an African swine fever virus random genomic library
    J S Jenson
    Department of Immunology, Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 ONF, UK
    J Immunol Methods 242:33-42. 2000
    The cellular immune recognition of peptides expressed by an African swine fever virus (ASFV) random genomic library has been studied...
  25. pmc Solution structures of 2 : 1 and 1 : 1 DNA polymerase-DNA complexes probed by ultracentrifugation and small-angle X-ray scattering
    Kuo Hsiang Tang
    Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 36:849-60. 2008
    ..velocity (SV) studies on the enzyme-DNA complexes of rat DNA polymerase beta (Pol beta) and African swine fever virus DNA polymerase X (ASFV Pol X) with one-nucleotide gapped DNA...
  26. ncbi Regulation of calcineurin by growth cone calcium waves controls neurite extension
    N J Lautermilch
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 20:315-25. 2000
    ..A and deltamethrin) and peptide inhibitors of CN [the Xenopus CN (xCN) autoinhibitory domain and African swine fever virus protein A238L] block the Ca(2+)-dependent reduction of neurite outgrowth in cultured neurons...
  27. ncbi Assembly of African Swine fever virus: quantitative ultrastructural analysis in vitro and in vivo
    S M Brookes
    BBSRC Institute for Animal Health, Pirbright Laboratory, Working, Surrey, England
    Virology 224:84-92. 1996
    b>African swine fever virus is an icosahedral double-standed DNA virus which replicates in the cytoplasm of porcine monocytic cells...
  28. ncbi Identification of the principal serological immunodeterminants of African swine fever virus by screening a virus cDNA library with antibody
    Simon D Kollnberger
    Department of Immunology, Institute for Animal Health, Pirbright, Ash Road, Woking, Surrey GU24 0NF, UK
    J Gen Virol 83:1331-42. 2002
    Protective immunity to African swine fever virus (ASFV) may involve a combination of both serological and cellular mechanisms. This work is focused on the identification of the possible relevant serological immunodeterminants of immunity...
  29. ncbi Characterization of immobilization methods for African swine fever virus protein and antibodies with a piezoelectric immunosensor
    E Uttenthaler
    Fraunhofer Institute for Solid State Technology, Munchen, Germany
    Biosens Bioelectron 13:1279-86. 1998
    A direct piezoelectric flow injection analysis immunoassay for the detection of African Swine Fever virus and antibodies is presented...
  30. ncbi Laboratory-scale inactivation of African swine fever virus and swine vesicular disease virus in pig slurry
    C Turner
    Silsoe Research Institute, Bedford, UK
    J Appl Microbiol 87:148-57. 1999
    ..ASF virus (ASFV) was less resistant to both methods than SVD virus (SVDV)...
  31. doi Comparison of the genome sequences of non-pathogenic and pathogenic African swine fever virus isolates
    David A G Chapman
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK
    J Gen Virol 89:397-408. 2008
    ..coding sequences, apart from the inverted terminal repeats and cross-links, have been determined for two African swine fever virus (ASFV) isolates from the same virus genotype, a non-pathogenic isolate from Portugal, OURT88/3, and a ..
  32. pmc African swine fever virus protein p17 is essential for the progression of viral membrane precursors toward icosahedral intermediates
    Cristina Suarez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    J Virol 84:7484-99. 2010
    The first morphological evidence of African swine fever virus (ASFV) assembly is the appearance of precursor viral membranes, thought to derive from the endoplasmic reticulum, within the assembly sites...
  33. ncbi Apoptosis induced in an early step of African swine fever virus entry into vero cells does not require virus replication
    Angel L Carrascosa
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Madrid, 28049, Spain
    Virology 294:372-82. 2002
    ..release of mitochondrial cytochrome c, and flow cytometric analysis of DNA content, upon infection with African swine fever virus (ASFV)...
  34. pmc The African swine fever virus virion membrane protein pE248R is required for virus infectivity and an early postentry event
    Irene Rodríguez
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Virol 83:12290-300. 2009
    The African swine fever virus (ASFV) protein pE248R, encoded by the gene E248R, is a late structural component of the virus particle...
  35. doi Prospects for development of African swine fever virus vaccines
    L K Dixon
    The Pirbright Institute, Ash Road, Pirbright, UK
    Dev Biol (Basel) 135:147-57. 2013
    b>African swine fever virus is a large DNA virus which can cause an acute haemorrhagic fever in pigs resulting in high mortality. No vaccine is available, limiting options for control...
  36. doi A study of lymphoid organs and serum proinflammatory cytokines in pigs infected with African swine fever virus genotype II
    Hovakim Zakaryan
    Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 0014, Yerevan, Armenia
    Arch Virol 160:1407-14. 2015
    b>African swine fever virus (ASFV), the causative agent of one of the most important viral diseases of domestic pigs for which no vaccine is available, causes immune system disorders in infected animals...
  37. pmc African Swine Fever Virus Georgia Isolate Harboring Deletions of MGF360 and MGF505 Genes Is Attenuated in Swine and Confers Protection against Challenge with Virulent Parental Virus
    Vivian O'Donnell
    Agricultural Research Service, USDA, Plum Island Animal Disease Center, Greenport, New York, USA Department of Pathobiology and Veterinary Science, CAHNR, University of Connecticut, Storrs, Connecticut, USA
    J Virol 89:6048-56. 2015
    b>African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal disease of domestic pigs that has significant economic consequences for the swine industry...
  38. doi A multiplex real-time PCR panel assay for simultaneous detection and differentiation of 12 common swine viruses
    Xiju Shi
    Beijing Entry Exit Inspection and Quarantine Bureau, Beijing, China Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States
    J Virol Methods 236:258-65. 2016
    ..The panel detects 12 viruses or viral serotypes, namely, VSV-IN, VSV-NJ, SVDV, CSFV, ASFV, FMDV, PCV2, PPV, PRV, PRRSV-NA, PRRSV-EU and SIV...
  39. pmc African swine fever virus gets undressed: new insights on the entry pathway
    German Andres
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    J Virol . 2016
    b>African swine fever virus (ASFV) is a large multienveloped DNA virus composed of a genome-containing core successively wrapped by an inner lipid envelope, an icosahedral protein capsid and an outer lipid envelope...
  40. pmc African swine fever virus infection of porcine aortic endothelial cells leads to inhibition of inflammatory responses, activation of the thrombotic state, and apoptosis
    I Vallee
    Department of Immunology and Pathology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, United Kingdom
    J Virol 75:10372-82. 2001
    ..It is caused by a large icosohedral double-stranded DNA virus, African swine fever virus (ASFV), with infection of macrophages well characterized in vitro and in vivo...
  41. pmc African Swine Fever virus proteinase is essential for core maturation and infectivity
    Ali Alejo
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Facultad de Ciencias, Cantoblanco, 28049 Madrid, Spain
    J Virol 77:5571-7. 2003
    b>African swine fever virus (ASFV) encodes two polyprotein precursors named pp220 and pp62 that are sequentially processed during viral infection, giving rise to six major structural proteins...
  42. pmc The subcellular distribution of multigene family 110 proteins of African swine fever virus is determined by differences in C-terminal KDEL endoplasmic reticulum retention motifs
    Christopher Netherton
    Division of Immunology, Pirbright Laboratory, Institute for Animal Health, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol 78:3710-21. 2004
    b>African swine fever virus (ASFV) is a large double-stranded DNA virus that replicates in discrete areas in the cytosol of infected cells called viral factories...
  43. pmc Preclinical diagnosis of African swine fever in contact-exposed swine by a real-time PCR assay
    L Zsak
    Plum Island Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, P O Box 848, Greenport, NY 11944 0848, USA
    J Clin Microbiol 43:112-9. 2005
    A fluorogenic probe hydrolysis (TaqMan) PCR assay for African swine fever virus (ASFV) was developed and evaluated in experimentally infected swine...
  44. pmc Regulation of inducible nitric oxide synthase expression by viral A238L-mediated inhibition of p65/RelA acetylation and p300 transactivation
    Aitor G Granja
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Madrid 28049, Spain
    J Virol 80:10487-96. 2006
    ..b>African swine fever virus (ASFV) infection regulates iNOS-induced gene expression through the synthesis of the A238L virus protein...
  45. ncbi Reduced redox potential of the cytosol is important for African swine fever virus capsid assembly and maturation
    Christian Cobbold
    Department of Biomedical and Biomolecular Sciences, Griffith University, Nathan, QLD 4111, Australia
    J Gen Virol 88:77-85. 2007
    Assembly of African swine fever virus (ASFV) involves the transfer of the major capsid protein, p73, from the cytosol onto the cytoplasmic face of endoplasmic reticulum-derived membranes...
  46. doi Cytokine mRNA expression and pathological findings in pigs inoculated with African swine fever virus (E-70) deleted on A238L
    F J Salguero
    Centro de Investigacion en Sanidad Animal, CISA INIA, Carretera Algete El Casar s n, Valdeolmos, 28130 Madrid, Spain
    Vet Immunol Immunopathol 124:107-19. 2008
    b>African swine fever virus (ASFV) induces a variety of immune responses and clinical forms in domestic pigs. As it is the only member of the Asfarviridae family, ASFV encodes many novel genes not encoded by other virus families...
  47. pmc African swine fever virus isolate, Georgia, 2007
    Rebecca J Rowlands
    Institute for Animal Health, Pirbright, UK
    Emerg Infect Dis 14:1870-4. 2008
    ..the genome of the isolates from domestic pigs in Georgia in 2007 were sequenced and compared with other ASF virus (ASFV) isolates to establish the genotype of the virus...
  48. pmc Remarkable sequence similarity between the dinoflagellate-infecting marine girus and the terrestrial pathogen African swine fever virus
    Hiroyuki Ogata
    Harmful Algal Bloom Division, National Research Institute of Inland Sea, Fisheries Research Agency, 2 17 5 Maruishi, Hatsukaichi, Hiroshima 739 0452, Japan
    Virol J 6:178. 2009
    ..insects (Iridoviridae), and the last one (Asfarviridae) exclusively represented by the animal pathogen African swine fever virus (ASFV), the agent of a fatal hemorrhagic disease in domestic swine...
  49. doi A host species-informative internal control for molecular assessment of African swine fever virus infection rates in the African sylvatic cycle Ornithodoros vector
    A D S Bastos
    Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria 0002, South Africa
    Med Vet Entomol 23:399-409. 2009
    b>African swine fever virus (ASFV) infection in adult Ornithodoros porcinus (Murry 1877, sensuWalton 1979) ticks collected from warthog burrows in southern and East Africa was assessed using a duplex genomic amplification approach that is ..
  50. doi Phylogenomic analysis of 11 complete African swine fever virus genome sequences
    Etienne P de Villiers
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Virology 400:128-36. 2010
    ..Whole genome phylogenetic analysis of 123 concatenated genes from 11 ASFV genomes, including E75, a newly sequenced virulent isolate from Spain, identified two clusters...
  51. pmc Control of African swine fever virus replication by small interfering RNA targeting the A151R and VP72 genes
    Djénéba Keita
    CIRAD, UMR CMAEE, Montpellier, France
    Antivir Ther 15:727-36. 2010
    b>African swine fever virus (ASFV) is the unique member of the Asfarviridae family and Asfivirus genus. It is an enveloped double-stranded DNA arbovirus that replicates in the cell cytoplasm, similar to poxviruses...
  52. pmc First detection of African Swine Fever Virus in Ornithodoros porcinus in Madagascar and new insights into tick distribution and taxonomy
    Julie Ravaomanana
    Centre of International Cooperation in Agricultural Research for Development CIRAD, CMAEE Unit, Campus International de Baillarguet, 34398 Montpellier Cedex 5, France
    Parasit Vectors 3:115. 2010
    b>African Swine Fever Virus has devastated more than the half of the domestic pig population in Madagascar since its introduction, probably in 1997-1998...
  53. doi Comparative inhibitory activity of the stilbenes resveratrol and oxyresveratrol on African swine fever virus replication
    I Galindo
    Dpt Biotecnología, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, INIA, Madrid, Spain
    Antiviral Res 91:57-63. 2011
    ..Here we tested the antiviral effect of these two compounds on African swine fever virus, the only member of the newly created family Asfarviridae and a serious limitation to porcine production ..
  54. pmc Kinetic mechanism of the ssDNA recognition by the polymerase X from African Swine Fever Virus. Dynamics and energetics of intermediate formations
    Maria J Jezewska
    Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch at Galveston, 77555 1053, United States
    Biophys Chem 158:9-20. 2011
    Kinetic mechanism of the ssDNA recognition by the polymerase X of African Swine Fever Virus (ASFV) and energetics of intermediate formations have been examined, using the fluorescence stopped-flow method...
  55. doi Molecular characterization of African swine fever virus isolates originating from outbreaks in the Russian Federation between 2007 and 2011
    Alexander Malogolovkin
    SRI National Research Institut for Veterinary Virology and Microbiology NRIVVaM, Russian Academy of Agricultural Science, 601120 Pokrov, Russia
    Vet Microbiol 158:415-9. 2012
    ..In order to study the evolution of African swine fever virus (ASFV) isolates, strains were collected in the Russian Federation from 2007 to 2011 and investigated by ..
  56. doi Tick-borne viruses in Europe
    Zdenek Hubalek
    Institute of Vertebrate Biology, v v i, Academy of Sciences of the Czech Republic, Květná 8, 60365, Brno, Czech Republic
    Parasitol Res 111:9-36. 2012
    ..TDMV), and Bauline (BAUV); two thogotoviruses (Thogoto THOV, Dhori DHOV); and one asfivirus (African swine fever virus ASFV)...
  57. pmc African swine fever virus uses macropinocytosis to enter host cells
    Elena G Sánchez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Madrid, Spain
    PLoS Pathog 8:e1002754. 2012
    African swine fever (ASF) is caused by a large and highly pathogenic DNA virus, African swine fever virus (ASFV), which provokes severe economic losses and expansion threats...
  58. doi African swine fever virus excretion patterns in persistently infected animals: a quantitative approach
    H C de Carvalho Ferreira
    Central Veterinary Institute, Part of Wageningen UR CVI, Virology Department, P O Box 65, 8200 AB Lelystad, The Netherlands
    Vet Microbiol 160:327-40. 2012
    ..In our study we have studied ASF virus (ASFV) excretion dynamics in persistently infected animals...
  59. doi African swine fever in the Russian Federation: spatio-temporal analysis and epidemiological overview
    A S Oganesyan
    Federal Center for Animal Health FGBI ARRIAH, mkr Yurevets, Vladimir 600901, Russian Federation
    Virus Res 173:204-11. 2013
    ..2) small-scale private holdings (low biosecurity population) are more exposed to ASF virus introduction; (3) there is a high risk of diffusion of ASFV from the secondary endemic zone in the central part of the RF to neighboring regions.
  60. doi ASFV in Tanzania: asymptomatic pigs harbor virus of molecular similarity to Georgia 2007
    A Uttenthal
    Section for Virology, National Veterinary Institute, Technical University of Denmark, Lindholm, DK 4771 Kalvehave, Denmark
    Vet Microbiol 165:173-6. 2013
    In 2011 African swine fever virus (ASFV) genome was detected in asymptomatic pigs in field samples in Mbeya, Tanzania...
  61. doi In vitro antiviral activity of fluoroquinolones against African swine fever virus
    Carla Mottola
    CIISA, Faculdade de Medicina Veterinaria, Universidade Tecnica de Lisboa, Av da Universidade Técnica, 1300 477 Lisboa, Portugal
    Vet Microbiol 165:86-94. 2013
    ..The antiviral effect of thirty fluoroquinolones on the infectivity of African swine fever virus (ASFV) was screened in vitro...
  62. pmc Involvement of the reparative DNA polymerase Pol X of African swine fever virus in the maintenance of viral genome stability in vivo
    Modesto Redrejo-Rodríguez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    J Virol 87:9780-7. 2013
    The function of the African swine fever virus (ASFV) reparative DNA polymerase, Pol X, was investigated in the context of virus infection...
  63. pmc Comprehensive phylogenetic reconstructions of African swine fever virus: proposal for a new classification and molecular dating of the virus
    Vincent Michaud
    CIRAD, UMR CMAEE, Montpellier, France
    PLoS ONE 8:e69662. 2013
    ..phylogenetic reconstructions were made using newly generated, publicly available sequences of hundreds of ASFV isolates from the past 70 years...
  64. doi Evaluation of hemostaseological status of pigs experimentally infected with African swine fever virus
    Hovakim Zakaryan
    Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, P O Box 0014, Yerevan, Armenia
    Vet Microbiol 174:223-8. 2014
    African swine fever is a highly contagious hemorrhagic disease of pigs caused by African swine fever virus (ASFV). Hemorrhages are the most frequently reported lesions in acute and subacute forms of ASF...
  65. doi African Swine Fever Diagnosis Adapted to Tropical Conditions by the Use of Dried-blood Filter Papers
    T Randriamparany
    Laboratoire National de Diagnostic Vétérinaire, Antananarivo, Madagascar
    Transbound Emerg Dis 63:379-88. 2016
    ..drying, shipment and long-term storage of blood at ambient temperature, and for the detection of African swine fever virus and antibodies was assessed...
  66. doi Detection of African Swine Fever Antibodies in Experimental and Field Samples from the Russian Federation: Implications for Control
    L Mur
    VISAVET Center and Animal Health Department, Veterinary School, Universidad Complutense de Madrid, Madrid, Spain
    Transbound Emerg Dis 63:e436-40. 2016
    ..Some studies have been performed with this ASFV isolate, revealing that it belongs to genotype II and causes an acute form of the disease...
  67. doi Investigation into the Epidemiology of African Swine Fever Virus at the Wildlife - Domestic Interface of the Gorongosa National Park, Central Mozambique
    C J Quembo
    Transboundary Animal Disease Program, Onderstepoort Veterinary Institute, Pretoria, South Africa
    Transbound Emerg Dis 63:443-51. 2016
    ..ticks, while ticks collected from pig pens were tested for the presence of ASFV. In addition, 310 framers were interviewed to gain a better understanding of the pig value chain and potential ..
  68. doi African swine fever virus infects macrophages, the natural host cells, via clathrin- and cholesterol-dependent endocytosis
    Inmaculada Galindo
    Department of Biotechnology, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA, Madrid, Spain Electronic address
    Virus Res 200:45-55. 2015
    The main cellular target for African swine fever virus (ASFV) is the porcine macrophage. However, existing data about the early phases of infection were previously characterized in non-leukocyte cells such as Vero cells...
  69. doi First molecular assessment of the African swine fever virus status of Ornithodoros ticks from Swaziland
    Carin I Boshoff
    Agricultural Research Council Onderstepoort Veterinary Institute, Transboundary Animal Diseases Programme, South Africa Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, South Africa Department of Biomedical Sciences, Tshwane University of Technology, South Africa
    Onderstepoort J Vet Res 81:E1-5. 2014
    ..It is caused by the African swine fever virus (ASFV), a deoxyribonucleic acid (DNA)arbovirus...
  70. pmc Cholesterol Flux Is Required for Endosomal Progression of African Swine Fever Virions during the Initial Establishment of Infection
    Miguel Angel Cuesta-Geijo
    Department of Biotechnology, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, Madrid, Spain
    J Virol 90:1534-43. 2015
    b>African swine fever virus (ASFV) is a major threat for porcine production that has been slowly spreading in Eastern Europe since its first appearance in the Caucasus in 2007...
  71. pmc Domain Organization of Vaccinia Virus Helicase-Primase D5
    Stephanie Hutin
    Institut de Biologie Structurale IBS, CEA, CNRS, University Grenoble Alpes, Grenoble, France
    J Virol 90:4604-13. 2016
    ..Similar structures of covalently linked extremities of the linear DNA genome are found in the African swine fever virus (asfarvirus) and in the Phycodnaviridae We are studying the machinery which replicates this peculiar ..
  72. doi Diagnosis and genotyping of African swine fever viruses from 2015 outbreaks in Zambia
    Jonas Thoromo
    Department of Disease Control, The University of Zambia
    Onderstepoort J Vet Res 83:a1095. 2016
    ..Molecular diagnosis by polymerase chain reaction targeting specific amplification of p72 (B646L) gene of ASF virus (ASFV) was conducted. Fourteen out of 16 domestic pigs from the affected provinces were found to be positive for ASFV...
  73. doi IL-23/IL-17/G-CSF pathway is associated with granulocyte recruitment to the lung during African swine fever
    Z Karalyan
    Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, 0014 Yerevan, Armenia Electronic address
    Vet Immunol Immunopathol 179:58-62. 2016
    ..The present study revealed that the production of IL-17 and IL-23 were significantly increased in the sera of ASFV infected pigs...
  74. ncbi Apigenin inhibits African swine fever virus infection in vitro
    Astghik Hakobyan
    Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS RA, 0014, Yerevan, Armenia
    Arch Virol 161:3445-3453. 2016
    b>African swine fever virus (ASFV) is one of the most devastating diseases of domestic pigs for which no effective vaccines are available...
  75. doi Influence of Age and Dose of African Swine Fever Virus Infections on Clinical Outcome and Blood Parameters in Pigs
    Jacob Post
    1 Department of Virology, Wageningen Bioveterinary Research, Lelystad, The Netherlands
    Viral Immunol 30:58-69. 2017
    ..Thirty percent of the pigs survived the infection with a moderately virulent strain of African swine fever virus (ASFV)...
  76. pmc Unravelling the armour of a killer: Evasion of host defence's by African swine fever virus
    Ana Luísa Reis
    The Pirbright Institute, Ash Road Pirbright, Woking, Surrey GU24 0NF, UK
    J Virol . 2016
    ..In pigs the virus replicates predominantly in macrophages. We review how the virus overcomes the barriers to replication in the macrophage and the virus mechanism to inhibit key host defence pathways...
  77. ncbi Isolation and molecular characterization of the swinepox virus thymidine kinase gene
    J A Feller
    Department of Immunology and Medical Microbiology, College of Medicine, University of Florida, Gainesville 32610
    Virology 183:578-85. 1991
    ..0%) and vertebrates (57.1-59.7%). The TK gene from African swine fever virus (ASF) showed little homology (30...
  78. ncbi African swine fever virus infection of skin-derived dendritic cells in vitro causes interference with subsequent foot-and-mouth disease virus infection
    D A Gregg
    Foreign Animal Disease Diagnostic Laboratory, National Veterinary Services Laboratories, APHIS, USDA, Greenport, NY 11944, USA
    J Vet Diagn Invest 7:44-51. 1995
    ..by a simple novel method were cultured for 24 hours before independent or sequential inoculation with African swine fever virus (ASFV) and foot-and-mouth disease virus (FMDV)...
  79. ncbi A viral mechanism for inhibition of the cellular phosphatase calcineurin
    J E Miskin
    Institute for Animal Health, Pirbright Laboratory, Pirbright, Surrey, GU24 0NF, UK
    Science 281:562-5. 1998
    ..b>African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was ..
  80. pmc African swine fever virus protein A238L interacts with the cellular phosphatase calcineurin via a binding domain similar to that of NFAT
    J E Miskin
    Institute for Animal Health, Pirbright Laboratory, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol 74:9412-20. 2000
    The African swine fever virus protein A238L inhibits activation of NFAT transcription factor by binding calcineurin and inhibiting its phosphatase activity. NFAT controls the expression of many immunomodulatory proteins...
  81. ncbi African swine fever virus protease, a new viral member of the SUMO-1-specific protease family
    G Andres
    Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 276:780-7. 2001
    b>African swine fever virus (ASFV) is a complex DNA virus that employs polyprotein processing at Gly-Gly-Xaa sites as a strategy to produce several major core components of the viral particle...
  82. pmc African swine fever virus IAP homologue inhibits caspase activation and promotes cell survival in mammalian cells
    M L Nogal
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Virol 75:2535-43. 2001
    b>African swine fever virus (ASFV) A224L is a member of the inhibitor of apoptosis protein (IAP) family. We have investigated the antiapoptotic function of the viral IAP both in stably transfected cells and in ASFV-infected cells...
  83. pmc Repression of African swine fever virus polyprotein pp220-encoding gene leads to the assembly of icosahedral core-less particles
    German Andres
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Virol 76:2654-66. 2002
    b>African swine fever virus (ASFV) polyprotein pp220, encoded by the CP2475L gene, is an N-myristoylated precursor polypeptide that, after proteolytic processing, gives rise to the major structural proteins p150, p37, p34, and p14...
  84. ncbi Orf virus encodes a functional dUTPase gene
    R Cottone
    Federal Research Centre for Virus Diseases of Animals, Institute for Immunology, Paul Ehrlich Strasse 28, D 72076 Tubingen, Germany
    J Gen Virol 83:1043-8. 2002
    ..0 microM, which is more similar to that of the mammalian or African swine fever virus enzyme than to the K(m) of vaccinia virus dUTPase...
  85. ncbi Structure-based combinatorial protein engineering (SCOPE)
    PAUL E O'MAILLE
    Ohio State Biochemistry Program, Ohio State University, 100 West 18th Avenue, Columbus, OH 43210 1173, USA
    J Mol Biol 321:677-91. 2002
    ..two distantly related members of the X-family of DNA polymerases: rat DNA polymerase beta (Pol beta) and African swine fever virus DNA polymerase X (Pol X)...
  86. ncbi Expression at mRNA level of cytokines and A238L gene in porcine blood-derived macrophages infected in vitro with African swine fever virus (ASFV) isolates of different virulence
    S Gil
    Laboratório Doenças Infecciosas, CIISA, Faculdade de Medicina Veterinaria, Lisboa, Portugal
    Arch Virol 148:2077-97. 2003
    Porcine macrophage cultures were infected with two ASFV isolates of variable virulence and mRNA levels of several relevant macrophage-derived cytokines were quantified by real time PCR...
  87. ncbi Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection
    C Sanchez-Torres
    Dpto Biotecnología, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA, Ctra de La Coruña Km 7 5, 28040 Madrid, Spain
    Arch Virol 148:2307-23. 2003
    Monocytes-macrophages, the target cells of African swine fever virus (ASFV) are highly heterogeneous in phenotype and function...
  88. ncbi The African swine fever virus dynein-binding protein p54 induces infected cell apoptosis
    Bruno Hernaez
    Dpto Biotecnología, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA, Ctra de la Coruña Km 7, 28040 Madrid, Spain
    FEBS Lett 569:224-8. 2004
    A specific interaction of ASFV p54 protein with 8 kDa light chain cytoplasmic dynein (DLC8) has been previously characterized and this interaction is critical during virus internalization and transport to factory sites...
  89. pmc Transport of African swine fever virus from assembly sites to the plasma membrane is dependent on microtubules and conventional kinesin
    Nolwenn Jouvenet
    Department of Immunology and Pathology, Institute for Animal Health, Surrey GU24 0NF, United Kingdom
    J Virol 78:7990-8001. 2004
    b>African swine fever virus (ASFV) is a large DNA virus that assembles in perinuclear viral factories located close to the microtubule organizing center...
  90. ncbi The C-type lectin homologue gene (EP153R) of African swine fever virus inhibits apoptosis both in virus infection and in heterologous expression
    Carolina Hurtado
    Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Virology 326:160-70. 2004
    The open reading frame EP153R of African swine fever virus (ASFV) encodes a nonessential protein that has been involved in the hemadsorption process induced in virus-infected cells...
  91. ncbi The viral protein A238L inhibits cyclooxygenase-2 expression through a nuclear factor of activated T cell-dependent transactivation pathway
    Aitor G Granja
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Biol Chem 279:53736-46. 2004
    ..Here we report that A238L, an African swine fever virus protein, efficiently inhibits cyclooxygenase-2 gene expression in Jurkat T cells and in virus-infected ..
  92. pmc Vimentin rearrangement during African swine fever virus infection involves retrograde transport along microtubules and phosphorylation of vimentin by calcium calmodulin kinase II
    Sandra Stefanovic
    Division of Immunology, Pirbright Laboratories, Institute for Animal Health, Surrey Ash Road, Woking, Surrey GU24 ONF, United Kingdom
    J Virol 79:11766-75. 2005
    b>African swine fever virus (ASFV) infection leads to rearrangement of vimentin into a cage surrounding virus factories...
  93. ncbi The viral protein A238L inhibits TNF-alpha expression through a CBP/p300 transcriptional coactivators pathway
    Aitor G Granja
    Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 176:451-62. 2006
    b>African swine fever virus (ASFV) is able to inhibit TNF-alpha-induced gene expression through the synthesis of A238L protein...
  94. pmc Antigenic properties and diagnostic potential of African swine fever virus protein pp62 expressed in insect cells
    Carmina Gallardo
    CISA INIA, Carretera Algete a El Casar, sn Valdeolmos, Madrid 28130, Spain
    J Clin Microbiol 44:950-6. 2006
    ..These features make pp62 one of the most interesting viral proteins to be used for serological ASF diagnosis...
  95. pmc African swine fever virus causes microtubule-dependent dispersal of the trans-golgi network and slows delivery of membrane protein to the plasma membrane
    Christopher L Netherton
    Pirbright Laboratory, Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol 80:11385-92. 2006
    ..b>African swine fever virus (ASFV) disrupts the trans-Golgi network (TGN) by altering the localization of TGN46, an organelle marker ..
  96. doi Apoptosis in porcine macrophages infected in vitro with African swine fever virus (ASFV) strains with different virulence
    Raquel Portugal
    Laboratório de Doenças Infecciosas, CIISA, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Av da Universidade Técnica, 1300 477, Lisbon, Portugal
    Arch Virol 154:1441-50. 2009
    b>African swine fever virus (ASFV) replicates in porcine macrophages...
  97. pmc A novel TLR3 inhibitor encoded by African swine fever virus (ASFV)
    V L de Oliveira
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, Oeiras, Portugal
    Arch Virol 156:597-609. 2011
    b>African swine fever virus (ASFV) encodes proteins that manipulate important host antiviral mechanisms...
  98. doi Genetic characterisation of African swine fever viruses from recent and historical outbreaks in Sardinia (1978-2009)
    Monica Giammarioli
    Istituto Zooprofilattico Sperimentale dell Umbria e delle Marche, Perugia, Italy
    Virus Genes 42:377-87. 2011
    Three discrete regions of the African swine fever virus (ASFV) were analysed in the genomes of a wide range of isolates collected from wild and domestic pigs in Sardinia, over a 31-year period (1978-2009)...
  99. pmc Mechanism of collapse of endoplasmic reticulum cisternae during African swine fever virus infection
    Miriam Windsor
    Institute for Animal Health, Pirbright Laboratory, Surrey, UK
    Traffic 13:30-42. 2012
    Infection of cells with African swine fever virus (ASFV) can lead to the formation of zipper-like stacks of structural proteins attached to collapsed endoplasmic reticulum (ER) cisternae...
  100. doi Methods for growing and titrating African swine fever virus: field and laboratory samples
    Angel L Carrascosa
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Curr Protoc Cell Biol . 2011
    Growing African swine fever virus (ASFV) isolates obtained mainly from the field, but also engineered in the laboratory, is a critical step for diagnosis, titration, or virus infection studies...
  101. doi Comparative evaluation of novel African swine fever virus (ASF) antibody detection techniques derived from specific ASF viral genotypes with the OIE internationally prescribed serological tests
    C Gallardo
    European Union Reference Laboratory for ASF URL CISA INIA, Valdeolmos, Madrid 28130, Spain
    Vet Microbiol 162:32-43. 2013
    ..We therefore conclude that the lack of success is not attributable to antigenic polymorphism and may be related to the specific characteristics of the local breeds African pigs...

Research Grants5

  1. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 2009
    ..Thus, chlorella viruses are an important model for studying large nucleocytoplasmic dsDNA viruses because they have evolutionary ties to important mammalian viruses, such as the pox viruses and the quarantined African swine fever virus.
  2. W M BUJALOWSKI; Fiscal Year: 2016
    ..Mammalian Polymerase ? (pol ?) and African Swine Fever Virus Polymerase X (pol X) provide outstanding model systems to study the molecular mechanism of the DNA ..
  3. Dynamic of Retroviruses Assembly and Budding
    NOLWENN MONIQUE JOUVENET; Fiscal Year: 2010
    ..Immunology of the Institute for Animal Health, England, where I studied the intracellular transport of African swine fever virus, a large DNA virus. My work led to the publication of 3 first-author papers...
  4. XIV International Poxvirus/Iridovirus Workshop
    EDWARD NILES; Fiscal Year: 2002
    ..Poxviruses are the focus of the majority of the presentations but studies of African Swine Fever Virus, Chlorella Viruses and a variety of iridoviruses are also significant contributions to the meeting...
  5. Structure-Function Relationship of DNA Polymerases
    Ming Daw Tsai; Fiscal Year: 2006
    ..contrasting properties will be studied: a high-fidelity enzyme, rat Pol beta, and a low-fidelity enzyme, African Swine Fever virus (ASFV) Pol X...

Patents4

  1. Enzymatic synthesis of L-nucleic acids
    Patent Number: JP2015516165-A; Date:2015-06-11
  2. Enzymatic synthesis of L-nucleic acids
    Patent Number: KR1020150013804-A; Date:2015-02-05
  3. CD2 DEFICIENT AFRICAN SWINE FEVER VIRUS AS LIVE ATTENUATED OR SUBSEQUENTLY INACTIVATED VACCINE AGAINST AFRICAN SWINE FEVER IN MAMMALS
    Patent Number: WO2015091322-A1; Date:2015-06-25
  4. Viral nucleic acid microarray and method of use
    Patent Number: WO2007130519-A2; Date:2007-11-15