Methanothermobacter thermautotrophicus str. Delta H

Summary

Alias: Methanobacterium thermoautotrophicum str. Delta H, Methanothermobacter thermautotrophicus str. deltaH, Methanobacterium thermoautotrophicum str. deltaH

Top Publications

  1. ncbi A unique organization of the protein subunits of the DNA polymerase clamp loader in the archaeon Methanobacterium thermoautotrophicum deltaH
    Z Kelman
    Department of Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 275:7327-36. 2000
  2. ncbi Genetic analysis of an archaeal Holliday junction resolvase in Escherichia coli
    E L Bolt
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2UH, UK
    J Mol Biol 310:577-89. 2001
  3. pmc Autophosphorylation of archaeal Cdc6 homologues is regulated by DNA
    B Grabowski
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Bacteriol 183:5459-64. 2001
  4. ncbi The structure and function of MCM from archaeal M. Thermoautotrophicum
    Ryan J Fletcher
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Science Center, School of Medicine, Denver, Colorado 80262, USA
    Nat Struct Biol 10:160-7. 2003
  5. pmc Biochemical characterization of Cdc6/Orc1 binding to the replication origin of the euryarchaeon Methanothermobacter thermoautotrophicus
    Stephanie A Capaldi
    Department of Molecular and Cell Biology, 227 Hildebrand Hall 3206, University of California Berkeley, Berkeley, CA 94720, USA
    Nucleic Acids Res 32:4821-32. 2004
  6. ncbi Structural polymorphism of Methanothermobacter thermautotrophicus MCM
    Yen Ju Chen
    Department of Biochemistry and Molecular Genetics, Box 800733, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Mol Biol 346:389-94. 2005
  7. ncbi A recombinant exonuclease III homologue of the thermophilic archaeon Methanothermobacter thermautotrophicus
    Sven Pfeifer
    Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig Biotechnological Biomedical Centre Leipzig, Bruderstrasse 34, 04103 Leipzig, Germany
    DNA Repair (Amst) 4:433-44. 2005
  8. doi Structure of the Methanothermobacter thermautotrophicus exosome RNase PH ring
    C Leong Ng
    York Structural Biology Laboratory, Chemistry Department, University of York, York YO10 5YW, England
    Acta Crystallogr D Biol Crystallogr 66:522-8. 2010
  9. ncbi Hydrogen-forming and coenzyme-F420-reducing methylene tetrahydromethanopterin dehydrogenase are genetically distinct enzymes in Methanobacterium thermoautotrophicum (Marburg)
    R von Bünau
    Molekulargenetik, Fachbereich Biologie, Philipps Universitat Marburg, Lahn, Federal Republic of Germany
    Eur J Biochem 202:1205-8. 1991
  10. ncbi The formylmethanofuran:tetrahydromethanopterin formyltransferase from Methanobacterium thermoautotrophicum delta H. Nucleotide sequence and functional expression of the cloned gene
    A A Dimarco
    Department of Microbiology, University of Illinois, Urbana 61801
    J Biol Chem 265:472-6. 1990

Research Grants

  1. Archaeal gene recruitment by the Chlamydiales
    David Graham; Fiscal Year: 2008

Patents

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
  2. Plants with increased yield
  3. Plants with increased yield
  4. Process for the production of lutein
  5. Process for the production of fine chemicals
  6. Process for the control of production of fine chemicals
  7. Proteins associated with abiotic stress response and homologs
  8. Pyroglue
  9. The production methods of optically active arylglycine derivatives

Scientific Experts

  • Z Kelman
  • Yosuke Koga
  • Jaume M Canaves
  • M Ibba
  • A Wasserfallen
  • H H Saxild
  • C Leong Ng
  • David E Graham
  • Hiromi Daiyasu
  • Dinesh Christendat
  • B Mukhopadhyay
  • Cheryl H Arrowsmith
  • R K Thauer
  • Adelinda Yee
  • Isabel L Woodman
  • Youxing Jiang
  • Emil F Pai
  • Dieter Soll
  • R Hedderich
  • Vivian Saridakis
  • Aaron W Fay
  • W Grabarse
  • Angelica M Bello
  • S Shima
  • Masahiro Fujihashi
  • U Ermler
  • Rajesh Kasiviswanathan
  • Cheryl Ingram-Smith
  • Frank J Smith
  • Amanda A Brindley
  • Alexandre Ambrogelly
  • Ana P G Silva
  • Michela Carella
  • Anselm Sauerwald
  • Godwin Amegbey
  • A M Edwards
  • David Kozono
  • Satwik Kamtekar
  • A Dharamsi
  • Constantinos Stathopoulos
  • N Wu
  • David S Wishart
  • A Yee
  • Edward L Bolt
  • Kristina Lakomek
  • Krisztina Toth
  • A Hochheimer
  • Sudeepa Bhattacharyya
  • Elena Ciirdaeva
  • Naoya Shinzato
  • Lars Schomacher
  • You Na Kang
  • J Chris Ellis
  • Stefanie Frank
  • J NOLLING
  • Olivier Julien
  • Jens Georg
  • Ewa Poduch
  • Sheng Ye
  • Lakshmi P Kotra
  • Yoichi Kamagata
  • E F Pai
  • Liping Chen
  • Thomas Spreter
  • Martin J Warren
  • Jianbo Dong
  • Yen Ju Chen
  • Helen K Leech
  • C H Arrowsmith
  • Heidi L Schubert
  • John K Lee
  • J Sivaraman
  • Deo Prakash Pandey
  • Sven Pfeifer
  • Jae Ho Shin
  • James W Brown
  • Pablo Gutierrez
  • Stephanie A Capaldi
  • Yoshichika Kitagawa
  • Peter Agre
  • M Goubeaud
  • Chang Hun Lee
  • Francisco J Blanco
  • Jin Won Jung
  • Weontae Lee
  • Godwin Y Amegbey
  • Xiao Tao
  • Bin Wu
  • William P Boomershine
  • Cheryl Arrowsmith

Detail Information

Publications128 found, 100 shown here

  1. ncbi A unique organization of the protein subunits of the DNA polymerase clamp loader in the archaeon Methanobacterium thermoautotrophicum deltaH
    Z Kelman
    Department of Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 275:7327-36. 2000
    ..The importance and roles of RFC and PCNA in M. thermoautotrophicum DeltaH replication are discussed...
  2. ncbi Genetic analysis of an archaeal Holliday junction resolvase in Escherichia coli
    E L Bolt
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2UH, UK
    J Mol Biol 310:577-89. 2001
    ..These results support models in which RecG acts at a replication fork stalled at a lesion in the DNA, catalysing fork regression and forming a Holliday junction that can then be acted upon by Hjc...
  3. pmc Autophosphorylation of archaeal Cdc6 homologues is regulated by DNA
    B Grabowski
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Bacteriol 183:5459-64. 2001
    ..Yeast Cdc18 was also found to autophosphorylate, suggesting that this function of Cdc6 may play a widely conserved and essential role in replication initiation...
  4. ncbi The structure and function of MCM from archaeal M. Thermoautotrophicum
    Ryan J Fletcher
    Department of Biochemistry and Molecular Genetics, University of Colorado Health Science Center, School of Medicine, Denver, Colorado 80262, USA
    Nat Struct Biol 10:160-7. 2003
    ..Yeast bypass experiments using MCM5 mutant proteins support the hypothesis for the bypass mechanism...
  5. pmc Biochemical characterization of Cdc6/Orc1 binding to the replication origin of the euryarchaeon Methanothermobacter thermoautotrophicus
    Stephanie A Capaldi
    Department of Molecular and Cell Biology, 227 Hildebrand Hall 3206, University of California Berkeley, Berkeley, CA 94720, USA
    Nucleic Acids Res 32:4821-32. 2004
    ..Our observations also indicate that the origin-binding properties of Cdc6/Orc1 proteins closely resemble those of bacterial DnaA...
  6. ncbi Structural polymorphism of Methanothermobacter thermautotrophicus MCM
    Yen Ju Chen
    Department of Biochemistry and Molecular Genetics, Box 800733, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Mol Biol 346:389-94. 2005
    ..This offers new insight into the conformational dynamics of MCM and the phosphorylation-bypass phenotype in yeast...
  7. ncbi A recombinant exonuclease III homologue of the thermophilic archaeon Methanothermobacter thermautotrophicus
    Sven Pfeifer
    Institute of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig Biotechnological Biomedical Centre Leipzig, Bruderstrasse 34, 04103 Leipzig, Germany
    DNA Repair (Amst) 4:433-44. 2005
    ..Considering the high intracellular potassium ion concentration in M. thermautotrophicus, our results suggest that the characterized thermophilic enzyme acts as an AP endonuclease in vivo with similar activities as Ape1...
  8. doi Structure of the Methanothermobacter thermautotrophicus exosome RNase PH ring
    C Leong Ng
    York Structural Biology Laboratory, Chemistry Department, University of York, York YO10 5YW, England
    Acta Crystallogr D Biol Crystallogr 66:522-8. 2010
    ....
  9. ncbi Hydrogen-forming and coenzyme-F420-reducing methylene tetrahydromethanopterin dehydrogenase are genetically distinct enzymes in Methanobacterium thermoautotrophicum (Marburg)
    R von Bünau
    Molekulargenetik, Fachbereich Biologie, Philipps Universitat Marburg, Lahn, Federal Republic of Germany
    Eur J Biochem 202:1205-8. 1991
    ..With purified enzyme preparations it is shown that the activity of the F420-reducing dehydrogenase is inhibited in the presence of the H2-forming enzyme. This finding is discussed in terms of substrate competition...
  10. ncbi The formylmethanofuran:tetrahydromethanopterin formyltransferase from Methanobacterium thermoautotrophicum delta H. Nucleotide sequence and functional expression of the cloned gene
    A A Dimarco
    Department of Microbiology, University of Illinois, Urbana 61801
    J Biol Chem 265:472-6. 1990
    ..The ftr gene encodes an acidic protein with a calculated molecular weight of 31,401. The sequence of FTR does not appear to be homologous to any other sequenced proteins, including proteins which use pterin substrates...
  11. pmc Cloning and characterization of the methyl coenzyme M reductase genes from Methanobacterium thermoautotrophicum
    M Bokranz
    Molekulargenetik, Philipps Universitat Marburg, Federal Republic of Germany
    J Bacteriol 170:568-77. 1988
    ..Sequence analysis revealed two more open reading frames of unknown function located between two of the methyl coenzyme M reductase genes...
  12. pmc Cloning and physical mapping of RNA polymerase genes from Methanobacterium thermoautotrophicum and comparison of homologies and gene orders with those of RNA polymerase genes from other methanogenic archaebacteria
    J Schallenberg
    Molekulargenetik, Fachbereich Biologie, Philipps Universitat, Marburg Lahn, Federal Republic of Germany
    J Bacteriol 170:2247-53. 1988
    ....
  13. ncbi Characterization of the superoxide dismutase gene and its upstream region from Methanobacterium thermoautotrophicum Marburg
    L Meile
    Institut für Lebensmittelwissenschaften, Eidgenössiche Technische Hochschule, ETH Zentrum, Zurich, Switzerland
    FEMS Microbiol Lett 128:247-53. 1995
    ..The amino acid sequence for this presumptive product had a similarity coefficient of 55.5% to a subunit of the alkyl hydroperoxide reductase (encoded by the ahpC gene) from Salmonella typhimurium...
  14. pmc Component A2 of methylcoenzyme M reductase system from Methanobacterium thermoautotrophicum delta H: nucleotide sequence and functional expression by Escherichia coli
    C H Kuhner
    Department of Microbiology, University of Illinois, Urbana 61801
    J Bacteriol 175:3195-203. 1993
    ..2-kb XmaI-BamHI fragment containing atwA and the surrounding open reading frames was cloned into pGEM-7Zf(+). A cell extract from this strain replaced purified A2 from M. thermoautotrophicum delta H in an in vitro methylreductase assay...
  15. pmc MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin
    M R Leroux
    Max Planck Institut fur Biochemie, Department of Cellular Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    EMBO J 18:6730-43. 1999
    ..In light of the absence of Hsp70 chaperones in many archaea, GimC may fulfil an ATP-independent, Hsp70-like function in archaeal de novo protein folding...
  16. ncbi The yexA gene product is required for phosphoribosylformylglycinamidine synthetase activity in Bacillus subtilis
    H H Saxild
    Department of Microbiology, Technical University of Denmark, Lyngby
    Microbiology 146:807-14. 2000
    ..The designation purS is proposed for this novel function in purine biosynthesis in B. subtilis...
  17. ncbi Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP
    D Christendat
    Division of Molecular and Structural Biology, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 275:24608-12. 2000
    ..The conservation of the active site residues suggests that the mechanism of action is also conserved and that the RmlC structure may be useful in guiding the design of antibacterial drugs...
  18. pmc Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum
    C D Mackereth
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Proc Natl Acad Sci U S A 97:6316-21. 2000
    ..One or more of these regions may contribute to the role of this subunit as a scaffold protein within the polymerase holoenzyme...
  19. ncbi Insights into ligand binding and catalysis of a central step in NAD+ synthesis: structures of Methanobacterium thermoautotrophicum NMN adenylyltransferase complexes
    V Saridakis
    Division of Molecular and Structural Biology, Ontario Cancer Institute, 610 University Avenue Toronto M5G 2M9, Ontario, Canada
    J Biol Chem 276:7225-32. 2001
    ..In addition, the role of the conserved (16)HXGH(19) active site motif in catalysis was probed by mutagenic, enzymatic and crystallographic techniques, including the characterization of an NMN(+)/SO4(2-) complex of mutant H19A NMNATase...
  20. ncbi Crystal structure of a heptameric Sm-like protein complex from archaea: implications for the structure and evolution of snRNPs
    B M Collins
    Department of Chemistry, Macquarie University, NSW 2109, Australia
    J Mol Biol 309:915-23. 2001
    ..In archaea, the gene encoding Lsm alpha is located next to the L37e ribosomal protein gene in a putative operon, suggesting a role for the Lsm alpha complex in ribosome function or biogenesis...
  21. ncbi Evolutionary divergence of the archaeal aspartyl-tRNA synthetases into discriminating and nondiscriminating forms
    Debra Tumbula-Hansen
    Department of Molecular Biophysics, Yale University, New Haven, Connecticut 06520 8114, USA
    J Biol Chem 277:37184-90. 2002
    ..The high sequence identity, up to 60% between discriminating and nondiscriminating archaeal AspRSs, suggests that few mutational steps may be necessary to convert the tRNA-discriminating ability of a tRNA synthetase...
  22. ncbi Functional expression and characterization of an archaeal aquaporin. AqpM from methanothermobacter marburgensis
    David Kozono
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    J Biol Chem 278:10649-56. 2003
    ..Our studies of archaeal AqpM demonstrate the ubiquity of aquaporins in nature and provide new insight into protein structure and transport selectivity...
  23. ncbi NMR structure determination and structure-based functional characterization of conserved hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum
    J R Cort
    Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    J Struct Funct Genomics 1:15-25. 2000
    ..The fold resembles that of Ribonuclease H and similar proteins, but differs from these in several respects, and is not likely to have a nuclease activity...
  24. pmc Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P
    William P Boomershine
    Biochemistry Program, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 100:15398-403. 2003
    ..Our findings represent a critical step toward a structural model of the RNase P holoenzyme from archaebacteria and higher organisms...
  25. ncbi Predicted role for the archease protein family based on structural and sequence analysis of TM1083 and MTH1598, two proteins structurally characterized through structural genomics efforts
    Jaume M Canaves
    The Joint Center for Structural Genomics, Bioinformatics Core, San Diego Supercomputer Center, La Jolla, California 92093 0527, USA
    Proteins 56:19-27. 2004
    ..The conservation of genomic context for this protein family is constant from Archaea and Bacteria to humans, and suggests that unannotated open reading frames contiguous to them could be novel RNA/DNA binding proteins...
  26. pmc Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes
    Deo Prakash Pandey
    Department of Biochemistry and Molecular Biology, University of Southern Denmark DK 5230 Odense M, Denmark
    Nucleic Acids Res 33:966-76. 2005
    ....
  27. ncbi Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI
    J Sivaraman
    Biotechnology Research Institute, National Research Council, Montreal, Quebec H4P 2R2, Canada, Montreal
    Biochemistry 44:10071-80. 2005
    ..The putative substrate-binding cleft is formed at the interface between the two monomers of the dimer. This fact, combined with the localization of the Zn(2+)-binding site, indicates that the enzyme is an obligate dimer...
  28. pmc Interactions between the archaeal Cdc6 and MCM proteins modulate their biochemical properties
    Rajesh Kasiviswanathan
    University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 33:4940-50. 2005
    ..The results also suggest that MCM and DNA may compete for Cdc6-1 protein binding. The implications of these observations for the initiation of archaeal DNA replication are discussed...
  29. ncbi Asymmetric behavior of archaeal prolyl-tRNA synthetase
    Alexandre Ambrogelly
    Department of Molecular Biophysics, Yale University, P O Box 208114, New Haven, CT 06520 8114, USA
    FEBS Lett 579:6017-22. 2005
    ..Together with previous reports our results show that asymmetry might be a general feature of the aminoacylation reaction catalyzed by dimeric aminoacyl-tRNA synthetases from both classes...
  30. pmc The Methanothermobacter thermautotrophicus ExoIII homologue Mth212 is a DNA uridine endonuclease
    Jens Georg
    Abteilung Molekulare Genetik und Präparative Molekularbiologie, Institut für Mikrobiologie und Genetik Georg August Universität, Gottingen, Grisebachstrasse 8, 37077 Gottingen, Germany
    Nucleic Acids Res 34:5325-36. 2006
    ..The U-endo activity of Mth212 is served by the same catalytic center as its AP-endo activity...
  31. ncbi Elucidation of substrate specificity in the cobalamin (vitamin B12) biosynthetic methyltransferases. Structure and function of the C20 methyltransferase (CbiL) from Methanothermobacter thermautotrophicus
    Stefanie Frank
    Protein Science Group, Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, United Kingdom
    J Biol Chem 282:23957-69. 2007
    ..The chemical logic underpinning the methylation is discussed...
  32. doi Molecular biology of Hel308 helicase in archaea
    Isabel L Woodman
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem Soc Trans 37:74-8. 2009
    ..We review the emerging molecular biology of Hel308, drawing together ideas of how it may contribute to genome stability through the control of recombination, with reference to paradigms developed in bacteria...
  33. doi Physical interaction between archaeal DNA repair helicase Hel308 and Replication Protein A (RPA)
    Isabel L Woodman
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG72UH, UK
    DNA Repair (Amst) 10:306-13. 2011
    ..This supports a model for RPA localising Hel308 to DNA damage sites in archaea, rather than it directly stimulating the mechanism of helicase unwinding...
  34. doi Structure-function relationship in an archaebacterial methionine sulphoxide reductase B
    Michela Carella
    Leibniz Institut für Altersforschung Fritz Lipmann Institut, Beutenbergstr 11, D 07745 Jena, Germany
    Mol Microbiol 79:342-58. 2011
    ..These findings imply a reaction cycle that differs from that observed for other MSRBs...
  35. pmc Identification and characterization of functional homologs of nitrogenase cofactor biosynthesis protein NifB from methanogens
    Aaron W Fay
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900
    Proc Natl Acad Sci U S A 112:14829-33. 2015
    ....
  36. pmc Structure and activity of a novel archaeal β-CASP protein with N-terminal KH domains
    Ana P G Silva
    York Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, United Kingdom
    Structure 19:622-32. 2011
    ..We hypothesize that this nuclease degrades mRNAs of proteins targeted for degradation and so regulates archaeal RNA turnover, possibly in concert with the exosome...
  37. pmc Role of motif III in catalysis by acetyl-CoA synthetase
    Cheryl Ingram-Smith
    Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634 0318, USA
    Archaea 2012:509579. 2012
    ..Interactions between these Asp and ATP are observed in all structures available for members of the superfamily, consistent with a critical role in substrate binding and catalysis for this invariant residue...
  38. pmc Crystal structure of a Ba(2+)-bound gating ring reveals elementary steps in RCK domain activation
    Frank J Smith
    Department of Biochemistry, Temple University School of Medicine, 3400 N Broad Street, Philadelphia, PA 19140, USA
    Structure 20:2038-47. 2012
    ..Our results suggest a working hypothesis for a sequence of ligand-dependent conformational changes that may underlie RCK domain activation and channel gating...
  39. ncbi H2-forming methylenetetrahydromethanopterin dehydrogenase, a novel type of hydrogenase without iron-sulfur clusters in methanogenic archaea
    C Zirngibl
    Laboratorium für Mikrobiologie des Fachbereichs Biologie, Philipps Universitat Marburg, Federal Republic of Germany
    Eur J Biochem 208:511-20. 1992
    ..thermoautotrophicum with respect both to molecular and catalytic properties...
  40. pmc Tryptophan gene cluster of Methanobacterium thermoautotrophicum Marburg: molecular cloning and nucleotide sequence of a putative trpEGCFBAD operon
    L Meile
    Mikrobiologisches Institut, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Bacteriol 173:5017-23. 1991
    ..With the exception of TrpB, the beta subunit of tryptophan synthase, tryptophan was absent from all Trp polypeptides...
  41. ncbi Isoleucyl-tRNA synthetase of Methanobacterium thermoautotrophicum Marburg. Cloning of the gene, nucleotide sequence, and localization of a base change conferring resistance to pseudomonic acid
    U Jenal
    Mikrobiologisches Institut, Eidgenossische Technische Hochschule, Zurich, Switzerland
    J Biol Chem 266:10570-7. 1991
    ..Both the mutant and the wild-type ileS gene were expressed in E. coli, and their products displayed the expected difference in sensitivity toward pseudomonic acid...
  42. ncbi Two genetically distinct methyl-coenzyme M reductases in Methanobacterium thermoautotrophicum strain Marburg and delta H
    S Rospert
    Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat Marburg, Federal Republic of Germany
    Eur J Biochem 194:871-7. 1990
    ..When the cultures were supplied with sufficient H2 and and CO2 and the cells grew exponentially, essentially only MCR II was found. When growth was limited by the gas supply, MCR I predominated...
  43. pmc A hydrogenase-linked gene in Methanobacterium thermoautotrophicum strain delta H encodes a polyferredoxin
    J N Reeve
    Department of Microbiology, Ohio State University, Columbus 43210
    Proc Natl Acad Sci U S A 86:3031-5. 1989
    ..The product of the mvhB gene is predicted to contain six tandomly repeated bacterial-ferredoxin-like domains and, therefore, is predicted to be a polyferredoxin that could contain as many as 48 iron atoms in 12 Fe4S4 clusters...
  44. pmc Relatedness of archaebacterial RNA polymerase core subunits to their eubacterial and eukaryotic equivalents
    B Berghöfer
    Department of Biology, Philipps University, Marburg, FRG
    Nucleic Acids Res 16:8113-28. 1988
    ..Putative functional domains were identified in two of the subunits of the archaebacterial enzyme...
  45. ncbi Sequence homologies in the N-terminal region of the ribosomal 'A' proteins from Methanobacterium Thermoautotrophicum and Halobacterium cutirubrum
    A T Matheson
    Biochim Biophys Acta 626:162-9. 1980
    ..The sequence data from the 'A' proteins also indicate that, phylogenetically, the archaebacteria are much closer to the cytoplasmic components of eucaryotes than they are to the eubacteria (or 'true bacteria')...
  46. ncbi The energy conserving N5-methyltetrahydromethanopterin:coenzyme M methyltransferase complex from Methanobacterium thermoautotrophicum is composed of eight different subunits
    U Harms
    Max Planck Institut fur terrestrische Mikrobiologie, Philipps Universitat, Marburg, Germany
    Eur J Biochem 228:640-8. 1995
    ..The mtr operon was found to be located between the methyl-coenzyme M reductase I operon (mcr) and a downstream open reading frame predicted to encode a Na+/Ca2+, K+ exchanger...
  47. ncbi Cloning, sequencing, and transcriptional analysis of the coenzyme F420-dependent methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase gene from Methanobacterium thermoautotrophicum strain Marburg and functional expression in Escherichia coli
    B Mukhopadhyay
    Department of Microbiology, University of Iowa, Iowa City 52242
    J Biol Chem 270:2827-32. 1995
    ..The mtd coding sequence was followed by several poly(dT) sequences and an inverted repeat that could be transcription termination signals...
  48. ncbi The heterodisulfide reductase from Methanobacterium thermoautotrophicum contains sequence motifs characteristic of pyridine-nucleotide-dependent thioredoxin reductases
    R Hedderich
    Max Planck Institut für terrestrische Mikrobiologie und Laboratorium für Mikrobiologie des Fachbereichs Biologie, Philipps Universitat Marburg, Germany
    Eur J Biochem 225:253-61. 1994
    ..46 kDa) did not show sequence similarity to other known proteins, but appears to possess a C-terminal hydrophobic alpha-helix that might function as a membrane anchor. Although hdrB and hdrC are juxtaposed, these genes are not near hdrA...
  49. pmc Growth phase-dependent transcription of the genes that encode the two methyl coenzyme M reductase isoenzymes and N5-methyltetrahydromethanopterin:coenzyme M methyltransferase in Methanobacterium thermoautotrophicum delta H
    T D Pihl
    Department of Microbiology, Ohio State University, Columbus 43210
    J Bacteriol 176:6384-91. 1994
    ....
  50. pmc Transcription of the ileS operon in the archaeon Methanobacterium thermoautotrophicum Marburg
    U Jenal
    Mikrobiologisches Institut, Swiss Federal Institute of Technology, ETH Zentrum, Zurich
    J Bacteriol 175:5945-52. 1993
    ..Extensive decay of the orf401-ileS-purL message was observed. Degradation occurred, presumably by endonucleolytic cleavage, within the orf401 region...
  51. pmc Cloning, sequencing, and growth phase-dependent transcription of the coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin reductase-encoding genes from Methanobacterium thermoautotrophicum delta H and Methanopyrus kandleri
    J NOLLING
    Department of Microbiology, Ohio State University, Columbus 43210, USA
    J Bacteriol 177:7238-44. 1995
    ....
  52. ncbi The tungsten formylmethanofuran dehydrogenase from Methanobacterium thermoautotrophicum contains sequence motifs characteristic for enzymes containing molybdopterin dinucleotide
    A Hochheimer
    Max Planck Institut fur terrestrische Mikrobiologie, Philipps Universitat, Marburg, Germany
    Eur J Biochem 234:910-20. 1995
    ..The fwd operon was found to be located in a region of the M. thermoautotrophicum genome encoding molybdenum enzymes and proteins involved in molybdopterin biosynthesis...
  53. ncbi Primary structure of cyclohydrolase (Mch) from Methanobacterium thermoautotrophicum (strain Marburg) and functional expression of the mch gene in Escherichia coli
    M Vaupel
    Max Planck Institut fur terrestrische Mikrobiologie, Marburg, Germany
    Eur J Biochem 236:294-300. 1996
    ..The mch gene was overexpressed in Escherichia coli yielding an active enzyme of 37 kDa with a specific activity of 30 U/mg cell extract protein...
  54. ncbi The hemA gene encoding glutamyl-tRNA reductase from the archaeon Methanobacterium thermoautotrophicum strain Marburg
    C Hungerer
    Laboratorium für Mikrobiologie des Fachbereich Biologie der Philipps Universität, Marburg, Germany
    Bioorg Med Chem 4:1089-95. 1996
    ..0. The reductase utilized preferentially NADPH for the reduction of the activated carboxyl group. The presence of ATP and GTP showed no obvious influence on catalysis...
  55. ncbi The molybdenum formylmethanofuran dehydrogenase operon and the tungsten formylmethanofuran dehydrogenase operon from Methanobacterium thermoautotrophicum. Structures and transcriptional regulation
    A Hochheimer
    Max Planck Institut fur terrestrische Mikrobiologie, Philipps Universitat Marburg, Germany
    Eur J Biochem 242:156-62. 1996
    ..thermo-autotrophicum revealed that the fwdHFGDACB gene cluster is transcribed in the presence of either molybdate or tungstate in the growth medium whereas the fmdECB gene cluster was only transcribed when molybdate was present...
  56. ncbi Properties of H. volcanii tRNA intron endonuclease reveal a relationship between the archaeal and eucaryal tRNA intron processing systems
    K Kleman-Leyer
    Department of Microbiology, The Ohio State University, Columbus 43210, USA
    Cell 89:839-47. 1997
    ..These results provide evidence that the archaeal and eucaryal tRNA intron processing systems are related and suggest a common origin for tRNA introns in these organisms...
  57. ncbi Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation
    U Ermler
    Max Planck Institut fur Biophysik, Heinrich Hoffmann Strabetae 7, 60528 Frankfurt, Germany
    Science 278:1457-62. 1997
    ..Together with a second structurally characterized enzyme state (MCRsilent) containing the heterodisulfide of coenzymes M and B, a reaction mechanism is proposed that uses a radical intermediate and a nickel organic compound...
  58. ncbi Purification, regulation, and molecular and biochemical characterization of pyruvate carboxylase from Methanobacterium thermoautotrophicum strain deltaH
    B Mukhopadhyay
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 273:5155-66. 1998
    ..thermoautotrophicum strain DeltaH (Kenealy, W. R., and Zeikus, J. G. (1982) FEMS Microbiol. Lett. 14, 7-10) raise several questions for future investigations...
  59. ncbi A family of flavoproteins in the domains Archaea and Bacteria
    A Wasserfallen
    Mikrobiologisches Institut, Eidgenossische Technische Hochschule, Zurich, Switzerland
    Eur J Biochem 254:325-32. 1998
    ..gigas hemoflavoprotein [Gomes, C. M., Silva, G., Oliveira, S., LeGall, J., Liu, M.-Y., Xavier, A. V., Rodrigues-Pousada, C. & Teixeira, M. (1997) J. Biol. Chem. 272, 22502-22508], is discussed...
  60. ncbi The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum isoenzyme by molybdate and constitutive synthesis of the tungsten isoenzyme
    A Hochheimer
    Max Planck Institut fur terrestrische Mikrobiologie, Fachbereich Biologie, Philipps Universitat, Marburg, Germany
    Arch Microbiol 170:389-93. 1998
    ..In both organisms, the tungsten isoenzyme was found to be constitutively transcribed, whereas the transcription of the molybdenum operon was induced by molybdate. Induction by molybdate was not significantly affected by tungstate...
  61. ncbi The energy conserving methyltetrahydromethanopterin:coenzyme M methyltransferase complex from methanogenic archaea: function of the subunit MtrH
    B Hippler
    Max Planck Institut für terrestrische Mikrobiologie and Laboratorium für Mikrobiologie des Fachbereichs Biologie der Philipps Universität, Marburg, Germany
    FEBS Lett 449:165-8. 1999
    ..Sequence comparison revealed similarity of MtrH with MetH from Escherichia coli and AcsE from Clostridium thermoaceticum: both enzymes exhibit methyltetrahydrofolate:cob(I)alamin methyltransferase activity...
  62. ncbi Methanobacterium thermoautotrophicum encodes two multisubunit membrane-bound [NiFe] hydrogenases. Transcription of the operons and sequence analysis of the deduced proteins
    A Tersteegen
    Max Planck Institut für Mikrobiologie, Marburg, Germany
    Eur J Biochem 264:930-43. 1999
    ..A function of these putative membrane-bound [NiFe] hydrogenases as proton pumps involved in endergonic reactions, such as the synthesis of formylmethanofuran from CO2, H2 and methanofuran, is discussed...
  63. ncbi Phenylalanyl-tRNA synthetase from the archaeon Methanobacterium thermoautotrophicum is an (alphabeta)2 heterotetrameric protein
    R Das
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114 USA
    Biochimie 81:1037-9. 1999
    ..Two ORFs with similarity to non-archaeal PheRSs alpha-subunits had previously been found in the genome sequence, but these results show that only one of them, MT742, is part of the active PheRS...
  64. ncbi The biosynthesis of methylated amino acids in the active site region of methyl-coenzyme M reductase
    T Selmer
    Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat, D 35032 Marburg, Germany
    J Biol Chem 275:3755-60. 2000
    ..A mechanism for the methylation of glutamine at C-2 and of arginine at C-5 is discussed...
  65. pmc Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase
    N Wu
    Department of Biochemistry, Centres of Excellence, University of Toronto, 1 King s College Circle, Toronto, ON Canada M5S 1A8
    Proc Natl Acad Sci U S A 97:2017-22. 2000
    ..The computational results are consistent with a catalytic mechanism that is characterized by Jencks's Circe effect...
  66. pmc Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum
    A Yee
    Division of Molecular and Structural Biology, Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada
    Proc Natl Acad Sci U S A 97:6311-5. 2000
    ..The position and conservation of charged surface residues suggests possible modes of interaction with other proteins, as well as a rationale for the thermal stability of this protein...
  67. ncbi Structure of coenzyme F(420) dependent methylenetetrahydromethanopterin reductase from two methanogenic archaea
    S Shima
    Max Planck Institut fur terrestrische Mikrobiologie, Karl von Frisch Strasse, Marburg, 35043, Germany
    J Mol Biol 300:935-50. 2000
    ..However, Mer and MetF do not show sequence similarities although they bind related substrates and catalyze an analogous reaction...
  68. ncbi Purification, crystallization and preliminary X-ray study of orotidine 5'-monophosphate decarboxylase
    N Wu
    Department of Biochemistry, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Acta Crystallogr D Biol Crystallogr 56:912-4. 2000
    ..0, b = 98.6, c = 73.3 A, gamma = 104.0 degrees ), with four molecules in the asymmetric unit; the crystals diffract to 1.5 A resolution...
  69. ncbi Rapid fold and structure determination of the archaeal translation elongation factor 1beta from Methanobacterium thermoautotrophicum
    G Kozlov
    McGill University, Department of Biochemistry, Montreal, PQ, Canada
    J Biomol NMR 17:187-94. 2000
    ..This novel feature was not observed previously and may serve a structural function related to protein stability or may play a functional role in archaeal protein translation...
  70. ncbi Domain-specific recruitment of amide amino acids for protein synthesis
    D L Tumbula
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    Nature 407:106-10. 2000
    ..Closer inspection of the two amidotransferases reveals that each of them recruited a metabolic enzyme to aid its function; this provides direct evidence for a relationship between amino-acid metabolism and protein biosynthesis...
  71. ncbi Structural proteomics of an archaeon
    D Christendat
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto 610 University Ave, Toronto, Ontario, Canada M5G 2M9
    Nat Struct Biol 7:903-9. 2000
    ..This demonstrates that structural proteomics is feasible and can play a central role in functional genomics...
  72. pmc The crystal structure of a heptameric archaeal Sm protein: Implications for the eukaryotic snRNP core
    C Mura
    University of California at Los Angeles Department of Energy Laboratory of Structural Biology and Molecular Medicine, 201 Boyer Hall Molecular Biology Institute, Box 951570, Los Angeles, CA 90095 1570, USA
    Proc Natl Acad Sci U S A 98:5532-7. 2001
    ..The pronounced electrostatic asymmetry of the SmAP surface imparts directionality to putative SmAP-RNA interactions...
  73. ncbi On the mechanism of biological methane formation: structural evidence for conformational changes in methyl-coenzyme M reductase upon substrate binding
    W Grabarse
    Max Planck Institut fur Biophysik, Frankfurt, Germany
    J Mol Biol 309:315-30. 2001
    ..The three different enzymatically inactive enzyme states are discussed with respect to their enzymatically active precursors and with respect to the catalytic mechanism...
  74. ncbi Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography
    Ning Wu
    Department of Biochemistry, Centres of Excellence, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Biochemistry 41:4002-11. 2002
    ..Consequently, orotidine 5'-monophosphate decarboxylases seem to require the presence of a negative charge at this position for catalysis as well as for correct and stable folding...
  75. ncbi Identification of a novel archaebacterial thioredoxin: determination of function through structure
    Sudeepa Bhattacharyya
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Biochemistry 41:4760-70. 2002
    ..On the basis of the results presented here, we predict that these small proteins are all members of a new class of truncated thioredoxins...
  76. ncbi Crystal structure and mechanism of a calcium-gated potassium channel
    Youxing Jiang
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:515-22. 2002
    ..Eight RCK domains (regulators of K(+) conductance) form a gating ring at the intracellular membrane surface. The gating ring uses the free energy of Ca(2+) binding in a simple manner to perform mechanical work to open the pore...
  77. ncbi The open pore conformation of potassium channels
    Youxing Jiang
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:523-6. 2002
    ..The open conformation favours high conduction by compressing the membrane field to the selectivity filter, and also permits large organic cations and inactivation peptides to enter the pore from the intracellular solution...
  78. pmc Deep trefoil knot implicated in RNA binding found in an archaebacterial protein
    Thomas I Zarembinski
    Biosciences Division, Structural Biology Center, Argonne National Laboratory, Argonne, Illinois 60439, USA
    Proteins 50:177-83. 2003
  79. pmc The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
    Satwik Kamtekar
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520 8114, USA
    Proc Natl Acad Sci U S A 100:1673-8. 2003
    ..jannaschii ProRS misacylates tRNA(Pro) with cysteine, and argue against the proposal that these archaeal ProRS enzymes possess the dual capacity to aminoacylate both tRNA(Pro) and tRNA(Cys) with their cognate amino acids...
  80. ncbi Analysis of membrane stereochemistry with homology modeling of sn-glycerol-1-phosphate dehydrogenase
    Hiromi Daiyasu
    Department of Computational Biology, Biomolecular Engineering Research Institute, 6 2 3, Furuedai, Suita, Osaka 565 0874, Japan
    Protein Eng 15:987-95. 2002
    ....
  81. ncbi A story of chelatase evolution: identification and characterization of a small 13-15-kDa "ancestral" cobaltochelatase (CbiXS) in the archaea
    Amanda A Brindley
    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 278:22388-95. 2003
    ..A classification scheme for chelatases is proposed...
  82. ncbi Mutational, structural, and kinetic studies of the ATP-binding site of Methanobacterium thermoautotrophicum nicotinamide mononucleotide adenylyltransferase
    Vivian Saridakis
    Molecular and Structural Biology, Ontario Cancer Institute, University Health Network, and the Department of Medical Biophysics, University of Toronto, Ontario, Canada
    J Biol Chem 278:34356-63. 2003
    ..3%, respectively, of WT NMNATase activity indicating that His-19 is a key catalytic group. Surprisingly, this H19A mutant displayed a novel and distinct mode of NAD+ binding when co-crystallized in the presence of NAD+ and SO42-...
  83. ncbi Structural and functional characterization of a thioredoxin-like protein (Mt0807) from Methanobacterium thermoautotrophicum
    Godwin Y Amegbey
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada T6G 2N8
    Biochemistry 42:8001-10. 2003
    ..thermoautotrophicum, while Mt0895 plays a minor or supportive role. We also suggest that these two molecules (Mt0807 and Mt0895) may represent a group of ancient proteins that were ancestral to both thioredoxins and glutaredoxins...
  84. ncbi Physiological role of the F420-non-reducing hydrogenase (Mvh) from Methanothermobacter marburgensis
    Alexander Stojanowic
    Max Planck Institut fur terrestrische Mikrobiologie, Karl von Frisch Strasse, 35043, Marburg, Germany
    Arch Microbiol 180:194-203. 2003
    ....
  85. ncbi Crystal structures of MTH1187 and its yeast ortholog YBL001c
    Xiao Tao
    Department of Biological Sciences, Northeast Structural Genomics Consortium, Columbia University, New York, New York 10027, USA
    Proteins 52:478-80. 2003
  86. ncbi Transfer of pro-R hydrogen from NADH to dihydroxyacetonephosphate by sn-glycerol-1-phosphate dehydrogenase from the archaeon Methanothermobacter thermautotrophicus
    Yosuke Koga
    Department of Chemistry, University of Occupational and Environmental Health, Kitakyushu, Japan
    Biosci Biotechnol Biochem 67:1605-8. 2003
    ..These results confirmed a prediction of the tertiary structure of sn-glycerol-1-phosphate dehydrogenase by homology modeling...
  87. pmc Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum
    Chang Hun Lee
    Department of Biochemistry, College of Science, Yonsei University, 134 Seodaemoon Gu, Shinchondong, Seoul, Korea 120 749
    Protein Sci 13:1148-54. 2004
    ..Therefore, we propose that the MTH1880 protein contains a novel motif for calcium-specific binding, and may function as a calcium buffering protein...
  88. pmc Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: a novel alpha+beta fold
    Francisco J Blanco
    NMR Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Protein Sci 13:1458-65. 2004
    ..coli...
  89. ncbi The crystal structure of archaeal nascent polypeptide-associated complex (NAC) reveals a unique fold and the presence of a ubiquitin-associated domain
    Thomas Spreter
    Institute for Chemistry Crystallography, Free University of Berlin, Takustrasse 6, D 14195 Berlin, Germany
    J Biol Chem 280:15849-54. 2005
    ..Based on the presented structure we propose a model for the eukaryotic heterodimeric NAC domain...
  90. ncbi Solution Structure of MTH0776 from Methanobacterium thermoautotrophicum
    Godwin Amegbey
    Department of Computing Science and Biological Sciences, University of Alberta, Edmonton, Alberta, Canada, T6G 2E8
    J Biomol NMR 33:51-6. 2005
  91. ncbi Structures of the MthK RCK domain and the effect of Ca2+ on gating ring stability
    Jianbo Dong
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 280:41716-24. 2005
    ..Additionally, our stability studies indicated that Ca2+ binding stabilizes the RCK domains in this octameric state...
  92. pmc Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A
    John K Lee
    Macromolecular Structure Group, Department of Biochemistry and Biophysics, University of California, S 412C Genentech Hall, 600 16th Street, San Francisco, CA 94143 2240, USA
    Proc Natl Acad Sci U S A 102:18932-7. 2005
    ..As a result of this and other side-chain substituents in the walls of the channel, the channel is intermediate in size and exhibits differentially tuned electrostatics when compared with the other subfamilies...
  93. ncbi MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like repeats
    Olivier Julien
    Département de biochimie et de microbiologie and CREFSIP, Universite Laval, 3255 pav Marchand, Quebec, G1K 7P4, Canada
    J Biomol NMR 35:149-54. 2006
    ..Harrison, D., Hoang, L., Keagle, P., Lumm, W., Pothier, B., Qiu, D., Spadafora, R., Vicaire, R., Wang, Y., Wierzbowski, J., Gibson, R., Jiwani, N., Caruso, A., Bush, D., Reeve, J. N. et al. (1997) J. Bacteriol., 179, 7135-7155]...
  94. ncbi Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels
    Sheng Ye
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 126:1161-73. 2006
    ..Our findings, along with the previously determined open MthK structure, allow us to elucidate the ligand gating mechanism of RCK-regulated K(+) channels...
  95. pmc Methanogens with pseudomurein use diaminopimelate aminotransferase in lysine biosynthesis
    David E Graham
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712 0165, USA
    FEBS Lett 582:1369-74. 2008
    ..In contrast marine methanogens from the Methanococcales, which lack pseudomurein, appear to use a different diaminopimelate pathway for lysine biosynthesis...
  96. pmc Specific DNA binding of a potential transcriptional regulator, inosine 5'-monophosphate dehydrogenase-related protein VII, to the promoter region of a methyl coenzyme m reductase I-encoding operon retrieved from Methanothermobacter thermautotrophicus stra
    Naoya Shinzato
    Center of Molecular Biosciences, University of the Ryukyus, Nishihara cho, Okinawa 903 0213, Japan
    Appl Environ Microbiol 74:6239-47. 2008
    ..The results presented here suggest that IMPDH VII encoded by MTH126 is a plausible candidate for the transcriptional regulator of the mcr operon in this methanogen...
  97. pmc Conformational flexibility and molecular interactions of an archaeal homologue of the Shwachman-Bodian-Diamond syndrome protein
    C Leong Ng
    York Structural Biology Laboratory, Chemistry Department, University of York, York, YO10 5YW, UK
    BMC Struct Biol 9:32. 2009
    ..Although genomic and biophysical studies have suggested involvement of this protein in RNA metabolism and in ribosome biogenesis, its interacting partners remain largely unknown...
  98. pmc An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms
    Krisztina Toth
    Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260 3000, USA
    Biochemistry 48:8006-13. 2009
    ....
  99. doi Crystal structure analysis of DNA uridine endonuclease Mth212 bound to DNA
    Kristina Lakomek
    Department of Molecular Structural Biology, Institute of Microbiology and Genetics, Georg August University Gottingen, Justus von Liebig Weg 11, D 37077 Gottingen, Germany
    J Mol Biol 399:604-17. 2010
    ..In addition, Ser171, Asn153, and Lys125 in the substrate binding pocket appear to have important functions in the discrimination of aberrant uridine against naturally occurring thymidine and cytosine residues in double-stranded DNA...
  100. ncbi Unique characteristics of superoxide dismutase of a strictly anaerobic archaebacterium Methanobacterium thermoautotrophicum
    M Takao
    Department of Biosciences, School of Hygienic Sciences, Kitasato University, Sagamihara, Japan
    J Biol Chem 266:14151-4. 1991
    ..Moreover, M. thermoautotrophicum SOD is resistant to azide and hydrogen peroxide as MnSODs are, suggesting that its evolution is distinct from known eubacterial FeSODs...
  101. ncbi Characterization of a superoxide dismutase gene from the archaebacterium Methanobacterium thermoautotrophicum
    M Takao
    Department of Bioscience, School of Hygienic Science, Kitasato University, Sagamihara, Japan
    Arch Biochem Biophys 283:210-6. 1990
    ..Between a putative promoter and the start codon there is an inverted repeat sequence which is also found in the counterpart of Halobacterium halobium...

Research Grants1

  1. Archaeal gene recruitment by the Chlamydiales
    David Graham; Fiscal Year: 2008
    ..Results from these experiments will support future microbiological studies of the role of this system in chlamydial infection and survival in the host cell. [unreadable] [unreadable] [unreadable]..

Patents9

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  2. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  3. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  4. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  5. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  6. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  7. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  8. Pyroglue
    Patent Number: WO2007054310-A2; Date:2007-05-18
  9. The production methods of optically active arylglycine derivatives
    Patent Number: JP2008113560-A; Date:2008-05-22