sea vase

Summary

Alias: yellow sea squirt, vase tunicate, Ciona intestinalis, Ascidia intestinalis, Ciona intestinalis (Linnaeus, 1767)

Top Publications

  1. pmc Cis-regulatory organization of the Pax6 gene in the ascidian Ciona intestinalis
    Steven Q Irvine
    Department of Biological Sciences, University of Rhode Island, 100 Flagg Road, Kingston, RI 02840, USA
    Dev Biol 317:649-59. 2008
  2. ncbi Complement in urochordates: cloning and characterization of two C3-like genes in the ascidian Ciona intestinalis
    Rita Marino
    Laboratory of Cell Biology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Immunogenetics 53:1055-64. 2002
  3. ncbi Expression of hedgehog genes in Ciona intestinalis embryos
    Naohito Takatori
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Japan
    Mech Dev 116:235-8. 2002
  4. ncbi Fgf genes in the basal chordate Ciona intestinalis
    Yutaka Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 212:432-8. 2002
  5. pmc A saturation screen for cis-acting regulatory DNA in the Hox genes of Ciona intestinalis
    David N Keys
    U S Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA
    Proc Natl Acad Sci U S A 102:679-83. 2005
  6. pmc Computational prediction and experimental validation of Ciona intestinalis microRNA genes
    Trina M Norden-Krichmar
    Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Drive, MSC 0202, La Jolla, CA 92093 USA
    BMC Genomics 8:445. 2007
  7. ncbi Characterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, Ciona intestinalis
    J C Corbo
    Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
    Development 124:589-602. 1997
  8. ncbi Cihox5, a new Ciona intestinalis Hox-related gene, is involved in regionalization of the spinal cord
    M Gionti
    Laboratory of Biochemistry and Molecular Biology, Stazione Zoologica Anton Dohrn, Villa Comunale, I 80121 Naples, Italy
    Dev Genes Evol 207:515-23. 1998
  9. ncbi Regulation of Ci-tropomyosin-like, a Brachyury target gene in the ascidian, Ciona intestinalis
    A Di Gregorio
    Department of Molecular and Cell Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720, USA
    Development 126:5599-609. 1999
  10. pmc mRNA 5'-leader trans-splicing in the chordates
    A E Vandenberghe
    Montreal Neurological Institute and Biology Department, McGill University, Montreal, Quebec, Canada H3A 2B4
    Genes Dev 15:294-303. 2001

Research Grants

  1. Michael S Levine; Fiscal Year: 2016
  2. William R Jeffery; Fiscal Year: 2014
  3. NEUROANATOMY OF THE ASCIDIAN LARVA--A CHORDATE MODEL
    J Whittaker; Fiscal Year: 1993
  4. Lionel Christiaen; Fiscal Year: 2016
  5. Functional Conservation of Myogenic Regulatory Factors
    Thomas H Meedel; Fiscal Year: 2010
  6. Lionel Christiaen; Fiscal Year: 2016
  7. Stephanie E Gline; Fiscal Year: 2014
  8. FUNCTION OF ELECTRICAL COUPLING IN EMBRYONIC TISSUE
    Michael Bennett; Fiscal Year: 1991
  9. Anna Di Gregorio; Fiscal Year: 2015
  10. Regulation of cardiac myocyte proliferation and myocardial regeneration in Ciona
    Heather J Evans Anderson; Fiscal Year: 2010

Patents

  1. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
  2. METHOD FOR THE PRODUCTION OF MULTIPLY-UNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS
  3. PROCESSES FOR PRODUCING LIPIDS
  4. ALTERNATIVE OXIDASE (AOX) PREVENTS SMOKING-ASSOCIATED LUNG DAMAGE
  5. PROCESSES FOR PRODUCING LIPIDS
  6. Method for increasing the content of polyunsaturated long-chained fatty acids in transgenic organisms
  7. METHOD FOR THE PRODUCTION OF MULTIPLY-UNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS
  8. Xylose isomerase genes and their use in fermentation of pentose sugars
  9. METHODS OF PRODUCING LIPIDS
  10. Expression of class 2 mannosidase and class iii mannosidase in lower eukaryotic cells

Detail Information

Publications206 found, 100 shown here

  1. pmc Cis-regulatory organization of the Pax6 gene in the ascidian Ciona intestinalis
    Steven Q Irvine
    Department of Biological Sciences, University of Rhode Island, 100 Flagg Road, Kingston, RI 02840, USA
    Dev Biol 317:649-59. 2008
    ..genomics since it has not been duplicated in tetrapods, making for a direct orthology between the Ciona intestinalis gene CiPax6 and Pax6 in mammals...
  2. ncbi Complement in urochordates: cloning and characterization of two C3-like genes in the ascidian Ciona intestinalis
    Rita Marino
    Laboratory of Cell Biology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Immunogenetics 53:1055-64. 2002
    ..we report the isolation of two C3-like genes, CiC3-1 and CiC3-2, from blood cell total RNA of the ascidian Ciona intestinalis. The deduced amino acid sequences of both Ciona C3-like proteins exhibit a canonical processing site for ..
  3. ncbi Expression of hedgehog genes in Ciona intestinalis embryos
    Naohito Takatori
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Japan
    Mech Dev 116:235-8. 2002
    ..The present study revealed that Ciona intestinalis contains two hedgehog genes (Ci-hh1 and Ci-hh2), which are likely to be independent duplicate genes in this ..
  4. ncbi Fgf genes in the basal chordate Ciona intestinalis
    Yutaka Satou
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 212:432-8. 2002
    ..To solve this problem, we have identified six FGF genes in a basal chordate, the ascidian Ciona intestinalis. A phylogenetic analysis confidently assigned two of them to vertebrate FGF8/17/18 and FGF11/12/13/14, ..
  5. pmc A saturation screen for cis-acting regulatory DNA in the Hox genes of Ciona intestinalis
    David N Keys
    U S Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA
    Proc Natl Acad Sci U S A 102:679-83. 2005
    ..within large (>100 kb) genomic domains containing Hox genes was performed by using the basal chordate Ciona intestinalis. Randomly generated DNA fragments from bacterial artificial chromosomes containing two clusters of Hox genes ..
  6. pmc Computational prediction and experimental validation of Ciona intestinalis microRNA genes
    Trina M Norden-Krichmar
    Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Drive, MSC 0202, La Jolla, CA 92093 USA
    BMC Genomics 8:445. 2007
    This study reports the first collection of validated microRNA genes in the sea squirt, Ciona intestinalis. MicroRNAs are processed from hairpin precursors to ~22 nucleotide RNAs that base pair to target mRNAs and inhibit expression...
  7. ncbi Characterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, Ciona intestinalis
    J C Corbo
    Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
    Development 124:589-602. 1997
    We present evidence that the embryo of the ascidian, Ciona intestinalis, is an easily manipulated system for investigating the establishment of basic chordate tissues and organs...
  8. ncbi Cihox5, a new Ciona intestinalis Hox-related gene, is involved in regionalization of the spinal cord
    M Gionti
    Laboratory of Biochemistry and Molecular Biology, Stazione Zoologica Anton Dohrn, Villa Comunale, I 80121 Naples, Italy
    Dev Genes Evol 207:515-23. 1998
    In this paper we report the cloning, sequence and expression analysis of a new Ciona intestinalis hox gene. On the basis of sequence comparison with mammalian and Amphioxus homologues, we called this gene Cihox5...
  9. ncbi Regulation of Ci-tropomyosin-like, a Brachyury target gene in the ascidian, Ciona intestinalis
    A Di Gregorio
    Department of Molecular and Cell Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720, USA
    Development 126:5599-609. 1999
    ..In ascidians, such as Ciona intestinalis, Brachyury is expressed exclusively in the notochord and does not exhibit an early pan-mesodermal pattern...
  10. pmc mRNA 5'-leader trans-splicing in the chordates
    A E Vandenberghe
    Montreal Neurological Institute and Biology Department, McGill University, Montreal, Quebec, Canada H3A 2B4
    Genes Dev 15:294-303. 2001
    ..In the ascidian protochordate Ciona intestinalis, the mRNAs of at least seven genes undergo trans-splicing of a 16-nucleotide 5'-leader apparently derived ..
  11. ncbi Induction of anterior neural fates in the ascidian Ciona intestinalis
    C Hudson
    Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS INSERM Universite de la Mediterranee AP de Marseille, France
    Mech Dev 100:189-203. 2001
    ..Here we report the isolation of two sensory vesicle markers in the ascidian Ciona intestinalis, which are homologs of vertebrate otx and gsx homeobox genes...
  12. ncbi A conserved role for the MEK signalling pathway in neural tissue specification and posteriorisation in the invertebrate chordate, the ascidian Ciona intestinalis
    Clare Hudson
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, CNRS INSERM Universite de la Mediterranee AP de Marseille, Parc Scientifique de Luminy, Case 907, 13288, Marseille Cedex 9, France
    Development 130:147-59. 2003
    ..analysed the role of the Ras/MEK/ERK signalling pathway in the formation of the larval CNS in the ascidian, Ciona intestinalis. We show evidence that this pathway is required, during the cleavage stages, for the acquisition of: (1) ..
  13. ncbi The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins
    Paramvir Dehal
    U S Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
    Science 298:2157-67. 2002
    ..vertebrates, we generated a draft of the protein-coding portion of the genome of the most studied ascidian, Ciona intestinalis. The Ciona genome contains approximately 16,000 protein-coding genes, similar to the number in other ..
  14. ncbi Origin of the vertebrate visual cycle: genes encoding retinal photoisomerase and two putative visual cycle proteins are expressed in whole brain of a primitive chordate
    Yuki Nakashima
    Department of Life Science, Graduate School of Science, Himeji Institute of Technology, Hyogo 678 1297, Japan
    J Comp Neurol 460:180-90. 2003
    ..protein (CRALBP) and beta-carotene 15,15'-monooxygenase (BCO)/RPE65 in a primitive chordate, ascidian Ciona intestinalis. The mRNAs for these proteins are specifically expressed in the central nervous system during embryonic ..
  15. ncbi Six novel gonadotropin-releasing hormones are encoded as triplets on each of two genes in the protochordate, Ciona intestinalis
    Bruce A Adams
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada V8W 3N5
    Endocrinology 144:1907-19. 2003
    ..We have identified two genes encoding GnRH in a protochordate, Ciona intestinalis, thought to be related to the ancestral animal that gave rise to vertebrates...
  16. ncbi A genomewide survey of developmentally relevant genes in Ciona intestinalis. III. Genes for Fox, ETS, nuclear receptors and NFkappaB
    Kasumi Yagi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 213:235-44. 2003
    A survey against the draft genome sequence and the cDNA/EST database of Ciona intestinalis identified a number of genes encoding transcription factors regulating a variety of processes including development...
  17. ncbi Complete mtDNA of Ciona intestinalis reveals extensive gene rearrangement and the presence of an atp8 and an extra trnM gene in ascidians
    Carmela Gissi
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita di Milano, Via Celoria 26, 20133 Milan, Italy
    J Mol Evol 58:376-89. 2004
    The complete mitochondrial genome (mtDNA) of the model organism Ciona intestinalis (Urochordata, Ascidiacea) has been amplified by long-PCR using specific primers designed on putative mitochondrial transcripts identified from publicly ..
  18. ncbi Identification of neuron-specific promoters in Ciona intestinalis
    Reiko Yoshida
    Department of Life Science, Graduate School of Science, Himeji Institute of Technology, Hyogo 678 1297, Japan
    Genesis 39:130-40. 2004
    ..each of which is expressed in distinct sets of neurons in the central nervous system of the ascidian Ciona intestinalis, and we examined their function by introducing green fluorescent protein (GFP)-fusion constructs into Ciona ..
  19. ncbi Making very similar embryos with divergent genomes: conservation of regulatory mechanisms of Otx between the ascidians Halocynthia roretzi and Ciona intestinalis
    Izumi Oda-Ishii
    Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, 1 1 Minamiohsawa, Hachiohji, Tokyo 192 0397, Japan
    Development 132:1663-74. 2005
    ..is almost perfectly conserved, even between the evolutionarily distant species Halocynthia roretzi and Ciona intestinalis, which show no detectable sequence conservation in the non-coding regions of studied orthologous genes...
  20. ncbi Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor
    Yoshimichi Murata
    Section of Developmental Neurophysiology, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Higashiyama 5 1, Myodaiji cho, Okazaki, Aichi, 444 8787, Japan
    Nature 435:1239-43. 2005
    ..Here we describe a novel protein from the ascidian Ciona intestinalis that has a transmembrane voltage-sensing domain homologous to the S1-S4 segments of voltage-gated channels ..
  21. ncbi Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes
    Yasushi Okamura
    Section of Developmental Neurophysiology, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki, Aichi, Japan
    Physiol Genomics 22:269-82. 2005
    ..Here we systematically survey up to 160 putative ion channel genes in the genome of Ciona intestinalis and compare them with corresponding gene sets from the genomes of the nematode Chaenorhabditis elegans, the ..
  22. ncbi Tunicate gonadotropin-releasing hormone (GnRH) peptides selectively activate Ciona intestinalis GnRH receptors and the green monkey type II GnRH receptor
    Javier A Tello
    Department of Biology, University of Victoria, P O Box 3020 STN CSC, Victoria, British Columbia, Canada V8W 3N5
    Endocrinology 146:4061-73. 2005
    ..have GnRH peptides because we previously reported six GnRH peptides encoded within the tunicate genome of Ciona intestinalis. Here we clone and sequence cDNAs for four putative GnRH receptors from C. intestinalis...
  23. pmc Genomic overview of mRNA 5'-leader trans-splicing in the ascidian Ciona intestinalis
    Yutaka Satou
    Department of Zoology, Graduate School of Science, Kyoto University Sakyo, Kyoto 606 8502, Japan
    Nucleic Acids Res 34:3378-88. 2006
    Although spliced leader (SL) trans-splicing in the chordates was discovered in the tunicate Ciona intestinalis there has been no genomic overview analysis of the extent of trans-splicing or the make-up of the trans-spliced and non-trans-..
  24. ncbi A signalling relay involving Nodal and Delta ligands acts during secondary notochord induction in Ciona embryos
    Clare Hudson
    Biologie du Développement, UMR 7009 CNRS Universite Pierre et Marie Curie Paris VI Villefranche sur Mer, France
    Development 133:2855-64. 2006
    ..We show that specification of the secondary but not the primary notochord in Ciona intestinalis requires a relay mechanism involving two signalling pathways...
  25. ncbi Nodal regulates neural tube formation in the Ciona intestinalis embryo
    Kaoru Mita
    Department of Materials Science, Kochi University, 2 5 1 Akebono cho, Kochi shi, Kochi 780 8520, Japan
    Dev Genes Evol 217:593-601. 2007
    ..of a lefty orthologue, Ci-lefty, caused a failure of neural tube closure in the protochordate ascidian Ciona intestinalis. The body bent dorsally, and anterior-posterior elongation was inhibited...
  26. ncbi FoxF is essential for FGF-induced migration of heart progenitor cells in the ascidian Ciona intestinalis
    Jeni Beh
    Center for Integrative Genomics, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Development 134:3297-305. 2007
    ..Taken together, our results indicate that FoxF is a direct target of FGF signaling and is predominantly involved in the regulation of heart cell migration...
  27. ncbi A combinatorial code of maternal GATA, Ets and beta-catenin-TCF transcription factors specifies and patterns the early ascidian ectoderm
    Ute Rothbächer
    Institut de Biologie du Developpement de Marseille Luminy IBDML, CNRS UMR6216 Université de la Méditerranée Aix Marseille, F 13288 Marseille Cedex 9, France
    Development 134:4023-32. 2007
    ..We thus identify a precise combinatorial code of maternal factors responsible for zygotic onset of a chordate ectodermal genetic program...
  28. ncbi Developmental expression of glutamic acid decarboxylase and of gamma-aminobutyric acid type B receptors in the ascidian Ciona intestinalis
    Giuliana Zega
    Dipartimento di Biologia, University of Milan, 20133, Milano, Italy
    J Comp Neurol 506:489-505. 2008
    We describe Ciona intestinalis gamma-aminobutyric acid (GABA)-ergic neurons during development, studying the expression pattern of Ci-GAD (glutamic acid decarboxylase: GABA synthesizing enzyme) by in situ hybridization...
  29. doi Glutamatergic networks in the Ciona intestinalis larva
    Takeo Horie
    Department of Life Science, Graduate School of Life Science, University of Hyogo, Hyogo 678 1297, Japan
    J Comp Neurol 508:249-63. 2008
    ..the vesicular glutamate transporter subfamily, a specific marker of glutamatergic neurons, in the ascidian Ciona intestinalis. The Ci-VGLUT gene is expressed in the adhesive organ, the epidermal neurons, and the brain vesicle, but not ..
  30. doi Pigmented and nonpigmented ocelli in the brain vesicle of the ascidian larva
    Takeo Horie
    Department of Life Science, Graduate School of Life Science, University of Hyogo, Hyogo 678 1297, Japan
    J Comp Neurol 509:88-102. 2008
    ..opsin, Ci-opsin1, is localized in the outer segments of the photoreceptor cells of larvae of the ascidian Ciona intestinalis. The absorption spectrum of the photopigment reconstituted from Ci-opsin1 and 11-cis-retinal suggested that ..
  31. pmc A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate
    Hirohide Iwasaki
    Section for Developmental Neurophysiology, Okazaki Center for Integrative Biosciences, National Institutes of Natural Sciences, 5 1 Higashiyama, Myodaiji cho, Okazaki, Aichi 4448787, Japan
    Proc Natl Acad Sci U S A 105:7970-5. 2008
    ..The enzymatic activity of Ciona intestinalis voltage sensor-containing phosphatase (Ci-VSP), recently identified as a member of the PTEN (phosphatase and ..
  32. pmc S4-based voltage sensors have three major conformations
    Carlos A Villalba-Galea
    Department of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Sciences Room W244, 929 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:17600-7. 2008
    ....
  33. pmc Brachyury null mutant-induced defects in juvenile ascidian endodermal organs
    Shota Chiba
    Department of Molecular, Cell and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Development 136:35-9. 2009
    We report the isolation of a recessive ENU-induced short-tailed mutant in the ascidian Ciona intestinalis that is the product of a premature stop in the brachyury gene...
  34. pmc The evolutionarily conserved leprecan gene: its regulation by Brachyury and its role in the developing Ciona notochord
    Matthew P Dunn
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Dev Biol 328:561-74. 2009
    In Ciona intestinalis, leprecan was identified as a target of the notochord-specific transcription factor Ciona Brachyury (Ci-Bra) (Takahashi, H., Hotta, K., Erives, A., Di Gregorio, A., Zeller, R.W., Levine, M., Satoh, N., 1999...
  35. pmc Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Development 136:3679-89. 2009
    ..an easily testable model for such investigations in a 155-bp notochord-specific CRM from the ascidian Ciona intestinalis. This CRM contains functional binding sites for both Ciona Brachyury (Ci-Bra) and FoxA (Ci-FoxA-a)...
  36. pmc Early chordate origins of the vertebrate second heart field
    Alberto Stolfi
    Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Science 329:565-8. 2010
    ..We found that heart progenitor cells of the simple chordate Ciona intestinalis also generate precursors of the atrial siphon muscles (ASMs)...
  37. pmc A single GATA factor plays discrete, lineage specific roles in ascidian heart development
    Katerina Ragkousi
    Molecular Cardiovascular Research Center, University of Arizona, Tucson, AZ 85724, USA
    Dev Biol 352:154-63. 2011
    ..Early heart specification in the invertebrate chordate Ciona intestinalis is similar to that of vertebrates but only one GATA factor, Ci-GATAa, is expressed in the heart progenitor ..
  38. doi Retinoic acid-driven Hox1 is required in the epidermis for forming the otic/atrial placodes during ascidian metamorphosis
    Yasunori Sasakura
    Shimoda Marine Research Center, University of Tsukuba, Shimoda, Shizuoka 415 0025, Japan
    Development 139:2156-60. 2012
    ..Here, we show that in the urochordate ascidian Ciona intestinalis, RA-Hox1 in the epidermal ectoderm is necessary for formation of the atrial siphon placode (ASP), a ..
  39. doi Transcriptional regulation of the peripheral nervous system in Ciona intestinalis
    W Joyce Tang
    Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA
    Dev Biol 378:183-93. 2013
    ..we investigated the roles played by PNG homologs in regulating PNS development of the invertebrate chordate Ciona intestinalis. We discovered that in Ciona, MyT1, Pou4, Atonal, and NeuroD-like are expressed in a sequential regulatory ..
  40. pmc Tbx2/3 is an essential mediator within the Brachyury gene network during Ciona notochord development
    Diana S José-Edwards
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Development 140:2422-33. 2013
    ..This work sheds light on a large section of the notochord regulatory circuitry controlled by T-box factors, and reveals new components of the complement of genes required for the proper formation of this structure...
  41. pmc NK4 antagonizes Tbx1/10 to promote cardiac versus pharyngeal muscle fate in the ascidian second heart field
    Wei Wang
    Department of Biology, New York University, New York, New York, United States of America
    PLoS Biol 11:e1001725. 2013
    ..We propose that this basic ontogenetic motif underlies cardiac and pharyngeal muscle development and evolution in chordates. ..
  42. ncbi Dynamic insertion-deletion of introns in deuterostome EF-1alpha genes
    Hiroshi Wada
    Seto Marine Biological Laboratory, Graduate School of Sciences, Kyoto University, 459 Shirahama, Wakayama, 649 2211, Japan
    J Mol Evol 54:118-28. 2002
    ..These analyses revealed that the deuterostome EF-1alpha gene has lost individual introns more frequently than all introns simultaneously...
  43. ncbi Developmental expression of ascidian neurotransmitter synthesis genes. I. Choline acetyltransferase and acetylcholine transporter genes
    Katsumi Takamura
    Department of Marine Biotechnology, Faculty of Engineering, Fukuyama University, 729 0292, Japan
    Dev Genes Evol 212:50-3. 2002
    To identify cholinergic neurons, we isolated a choline acetyltransferase (Ci-ChAT) gene from Ciona intestinalis by PCR methods. In the cloning process, we also obtained the gene encoding the vesicular acetylcholine transporter (Ci-vAChTP)...
  44. ncbi The dopamine-synthesizing cells in the swimming larva of the tunicate Ciona intestinalis are located only in the hypothalamus-related domain of the sensory vesicle
    Frederic Moret
    Development, Evolution, Plasticity of the Nervous System, UPR 2197, Institut de Neurobiologie Alfred Fessard, C N R S, 1, Ave de la Terrasse, F 91198 Gif sur Yvette, France
    Eur J Neurosci 21:3043-55. 2005
    ..a high-resolution cellular analysis of tyrosine hydroxylase (TH)-positive and dopamine-positive cells in Ciona intestinalis embryos and larvae...
  45. pmc Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif
    Valentina A Shchedrina
    Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 0664, USA
    Proc Natl Acad Sci U S A 104:13919-24. 2007
    ..In a bacterial expression system, we directly demonstrated the formation of a diselenide bond between the two Sec, establishing it as the first diselenide bond found in a natural protein...
  46. doi Gene expression profile of Ci-VSP in juveniles and adult blood cells of ascidian
    Michio Ogasawara
    Department of Nanobiology, Graduate School of Advanced Integration Science, Chiba University, Yayoi cho 1 33, Inage Ku, Chiba 263 8522, Japan
    Gene Expr Patterns 11:233-8. 2011
    ..pattern of ascidian VSP(Ci-VSP) was examined in embryos and juveniles of a marine invertebrate chordate, Ciona intestinalis. RT-PCR showed that Ci-VSP is expressed at the larval stage and that expression persists in juveniles...
  47. pmc Precraniate origin of cranial motoneurons
    Héloïse D Dufour
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8542, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Proc Natl Acad Sci U S A 103:8727-32. 2006
    ..The motoneurons of adult Ciona intestinalis, located in the cerebral ganglion and innervating muscles associated with the huge "branchial basket," ..
  48. ncbi Origin of the vertebrate visual cycle: III. Distinct distribution of RPE65 and beta-carotene 15,15'-monooxygenase homologues in Ciona intestinalis
    Noriko Takimoto
    Department of Life Science, Graduate School of Life Science, University of Hyogo, 3 2 1 Kouto, Kamigori, Ako gun, Hyogo 678 1297, Japan
    Photochem Photobiol 82:1468-74. 2006
    ..retinaldehyde-binding protein (Ci-CRALBP) and beta-carotene 15,15'-monooxygenase (Ci-BCO) in the ascidian Ciona intestinalis. Ci-opsin3 and Ci-CRALBP are localized in both ocellus photoreceptor cells and surrounding non-photoreceptor ..
  49. pmc Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene
    Kseniya Golovnina
    Institute of Cytology and Genetics, Russian Academy of Sciences, 630090, Novosibirsk, Russia
    BMC Evol Biol 5:69. 2005
    ..While merlin's functional activity has been examined in mammalian and Drosophila models, little is understood about its evolution, diversity, and overall distribution among different taxa...
  50. ncbi Evidence for a dispersed Hox gene cluster in the platyhelminth parasite Schistosoma mansoni
    Raymond J Pierce
    INSERM U 547, Institut Pasteur de Lille, France
    Mol Biol Evol 22:2491-503. 2005
    ..as is the case for the ecdysozoans Drosophila melanogaster and Caenorhabditis elegans and the urochordates Ciona intestinalis and Oikopleura dioica...
  51. ncbi GABAergic synaptic transmission modulates swimming in the ascidian larva
    E R Brown
    Neurobiology Laboratory, Stazione Zoologica Anton Dohrn, Villa Communale, I 80121 Naples, Italy
    Eur J Neurosci 22:2541-8. 2005
    ..of swimming and the morphology of GABA-immunopositive neurones in tadpole larvae of the ascidians Ciona intestinalis and Ciona savignyi...
  52. ncbi Further EST analysis of endocrine genes that are preferentially expressed in the neural complex of Ciona intestinalis: receptor and enzyme genes associated with endocrine system in the neural complex
    Toshio Sekiguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Gen Comp Endocrinol 150:233-45. 2007
    ..In the present study, we investigated endocrine-related genes expressed in the neural complex of Ciona intestinalis. Comprehensive analyses of 3'-end sequences of the neural complex cDNAs placed 10,029 clones into 4051 ..
  53. ncbi CiC3-1a-mediated chemotaxis in the deuterostome invertebrate Ciona intestinalis (Urochordata)
    Maria Rosaria Pinto
    Laboratory of Cell Biology, Stazione Zoologica A Dohrn, Napoli, Italy
    J Immunol 171:5521-8. 2003
    ..of the presence of an inflammatory pathway in ascidians, we expressed in Escherichia coli the fragment of Ciona intestinalis C3-1 corresponding to mammalian complement C3a (rCiC3-1a) and assessed its chemotactic activity on C...
  54. ncbi Toxicity of organic compounds to marine invertebrate embryos and larvae: a comparison between the sea urchin embryogenesis bioassay and alternative test species
    Juan Bellas
    Laboratorio de Ecoloxía Mariña, Departamento de Ecoloxia e Bioloxia Animal, Universidade de Vigo, Campus Lagoas Marcosende, E 36200, Vigo, Galicia, Spain
    Ecotoxicology 14:337-53. 2005
    ..dodecyl sulfate (SDS) on the early life stages of Paracentrotus lividus (Echinodermata, Euechinoidea), Ciona intestinalis (Chordata, Ascidiacea), Maja squinado and Palaemon serratus (Arthropoda, Crustacea) in laboratory acute ..
  55. ncbi Immunoglobulin superfamily receptors in protochordates: before RAG time
    Louis Du Pasquier
    Institute of Zoology, University of Basel, Basel, Switzerland
    Immunol Rev 198:233-48. 2004
    ..In the genome of Ciona intestinalis, genes that encode molecules with membrane receptor features have been found among many members of the ..
  56. ncbi Sphingomyelins in four ascidians, Ciona intestinalis, Halocynthia roretzi, Halocynthia aurantium, and Styela clava
    Masahiro Ito
    Department of Bioinformatics, Institute of Science and Engineering, Ritsumeikan University, Shiga 525 8577, Japan
    J Oleo Sci 58:473-80. 2009
    ..In this study, sphingomyelin was first isolated and characterized from ascidian Ciona intestinalis. Ascidian sphingomyelin was prepared using ion exchange (QAE-Sphadex-A25) and silicic acid (Florisil and ..
  57. doi Neuropeptides, hormone peptides, and their receptors in Ciona intestinalis: an update
    Tsuyoshi Kawada
    Suntory Institute for Bioorganic Research, 1 1 1 Wakayamadai, Shimamoto, Mishima, Osaka 618 8503, Japan
    Zoolog Sci 27:134-53. 2010
    ..in vertebrates are highly likely to be evolutionarily conserved in ascidians, and the cosmopolitan species Ciona intestinalis is expected to be an excellent deuterostome Invertebrate model for studies on neuropeptides and hormones...
  58. ncbi Acrosome differentiation in the ascidians Clavelina lepadiformis and Ciona intestinalis
    M Fukumoto
    Division of Cell Function, Institute of Natural Sciences INS, Nagoya City University, Japan
    Cell Tissue Res 302:105-14. 2000
    The spermatozoa of both Clavelina lepadiformis and Ciona intestinalis have architectural features characteristic of ascidian spermatozoa that have been previously described...
  59. doi Effects of the azole fungicide Imazalil on the development of the ascidian Ciona intestinalis (Chordata, Tunicata): morphological and molecular characterization of the induced phenotype
    Giuliana Zega
    Dipartimento di Biologia, Universita di Milano, Via Celoria, 26, I 20133 Milano, Italy
    Aquat Toxicol 91:255-61. 2009
    ..In this work, we tested the effects of IMA on the development of the solitary ascidian Ciona intestinalis by treating two-cell stage embryos with a range of concentrations (0.1, 0.5, 1, 2...
  60. doi SL RNA genes of the ascidian tunicates Ciona intestinalis and Ciona savignyi
    Brendan Yeats
    Montreal Neurological Institute and Department of Biology, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Zoolog Sci 27:171-80. 2010
    We characterized by bioinformatics the trans-spliced leader donor RNA (SL RNA) genes of two ascidians, Ciona intestinalis and Ciona savignyi...
  61. ncbi The Sea Squirt Ciona intestinalis
    Lionel Christiaen
    Molecular and Cell Biology Department, University of California, Berkeley, California 94720, USA
    CSH Protoc 2009:pdb.emo138. 2009
    INTRODUCTION Sea squirts (Ciona intestinalis) are tunicates (or urochordates), the closest living relatives of the vertebrates...
  62. pmc Transposon-mediated insertional mutagenesis revealed the functions of animal cellulose synthase in the ascidian Ciona intestinalis
    Yasunori Sasakura
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 102:15134-9. 2005
    ..Transposon-based mutagenesis in an ascidian, Ciona intestinalis, has generated a mutant, swimming juvenile (sj)...
  63. ncbi Neuroendocrinology of protochordates: insights from Ciona genomics
    Nancy M Sherwood
    Department of Biology, University of Victoria, Victoria, B C, Canada V8W 3N5
    Comp Biochem Physiol A Mol Integr Physiol 144:254-71. 2006
    ..In this review most of the data is from Ciona intestinalis, as the annotation of the C. savignyi genome is not yet available...
  64. doi M-Ras evolved independently of R-Ras and its neural function is conserved between mammalian and ascidian, which lacks classical Ras
    Etsuko Keduka
    Department of Biology, Graduate School of Science, Chiba University, 1 33 Yayoicho, Inageku, Chiba, Chiba 263 8522, Japan
    Gene 429:49-58. 2009
    ..Analyses of DNA databases revealed that no gene encoding classical Ras is present in the ascidians, Ciona intestinalis and Halocynthia roretzi, despite the presence of classical Ras-orthologous genes in nematode, fly, amphioxus,..
  65. doi Identification of chondroitin/dermatan sulfotransferases in the protochordate, Ciona intestinalis
    Akira Tetsukawa
    Department of Applied Science, Faculty of Science, Kochi University, 2 5 1 Akebono cho, Kochi shi, Kochi 780 8520, Japan
    Comp Biochem Physiol B Biochem Mol Biol 157:205-12. 2010
    ..genes encoding proteins homologous to chondroitin/dermatan sulfotransferases in the genome of the ascidian Ciona intestinalis. We found eight genes encoding 4-O-sulfotransferases, eight genes encoding 6-O-sulfotransferases, and three ..
  66. pmc Natural variation of model mutant phenotypes in Ciona intestinalis
    Paolo Sordino
    Laboratory of Biochemistry and Molecular Biology, Stazione Zoologica Anton Dohrn, Naples, Italy
    PLoS ONE 3:e2344. 2008
    ..To provide further information to support forward genetics in Ciona intestinalis, we used a combination of natural variation and neutral population genetics as an approach for the ..
  67. doi Distinctive expression patterns of Hedgehog pathway genes in the Ciona intestinalis larva: implications for a role of Hedgehog signaling in postembryonic development and chordate evolution
    A F M Tariqul Islam
    Graduate School of Life Science, University of Hyogo, Hyogo 678 1297, Japan
    Zoolog Sci 27:84-90. 2010
    ..Ci-hh2), patched (Ci-ptc), smoothened (Ci-smo), and Gli (Ci-Gli) orthologs in larvae of the ascidian Ciona intestinalis. The expression patterns of Ci-hh2 and Ci-Gli dramatically change during the period between the late tailbud ..
  68. pmc Ciona intestinalis as an emerging model organism: its regeneration under controlled conditions and methodology for egg dechorionation
    Li Ping Liu
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
    J Zhejiang Univ Sci B 7:467-74. 2006
    The ascidian Ciona intestinalis is a model organism of developmental and evolutionary biology and may provide crucial clues concerning two fundamental matters, namely, how chordates originated from the putative deuterostome ancestor and ..
  69. pmc Dynamic and polarized muscle cell behaviors accompany tail morphogenesis in the ascidian Ciona intestinalis
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 2:e714. 2007
    ..Investigating the cell behaviors underlying the morphogenesis of muscle in ascidians may therefore reveal the evolutionarily conserved mechanisms operating during this process...
  70. doi Delineating metamorphic pathways in the ascidian Ciona intestinalis
    Akie Nakayama-Ishimura
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, Japan
    Dev Biol 326:357-67. 2009
    ..In the present study, we approached this question using the ascidian Ciona intestinalis. When the papillae and preoral lobes of the larvae were cut off, the papillae-cut larvae initiated certain ..
  71. doi A cis-regulatory signature in ascidians and flies, independent of transcription factor binding sites
    Pierre Khoueiry
    Institut du Biologie de Développement de Marseille Luminy IBDML, UMR 6216, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy Case 907, F 13288, Marseille Cedex 9, France
    Curr Biol 20:792-802. 2010
    ..Although these modules are usually made of clusters of short transcription factor binding sites, a small minority of such clusters in the genome have cis-regulatory activity. This paradox is currently unsolved...
  72. ncbi Neurogenic and non-neurogenic placodes in ascidians
    Lucia Manni
    Dipartimento di Biologia, Universita di Padova, I 35121 Padova, Italy
    J Exp Zool B Mol Dev Evol 302:483-504. 2004
    The late differentiation of the ectodermal layer is analysed in the ascidians Ciona intestinalis and Botryllus schlosseri, by means of light and electron microscopy, in order to verify the possible presence of placodal structures...
  73. doi Allorecognition mechanisms during ascidian fertilization
    Yoshito Harada
    Sugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University, Sugashima, Toba, Japan
    Int J Dev Biol 52:637-45. 2008
    ..But, many ascidians, including Ciona intestinalis and Halocynthia roretzi, show self-sterility or preference for cross-fertilization rather than self-..
  74. ncbi Urochordates carry multiple genes for goose-type lysozyme and no genes for chicken- or invertebrate-type lysozymes
    I W Nilsen
    Marine Biotechnology and Fish Health, Norwegian Institute of Fisheries and Aquaculture Research, 9291 Tromsø, Norway
    Cell Mol Life Sci 60:2210-8. 2003
    Genome clones and expressed sequence tags (ESTs) from the ascidian Ciona intestinalis and from the larvacean Oikopleura dioica were analysed for the presence of lysozyme-encoding genes...
  75. ncbi A cDNA microarray technique applied for analysis of global gene expression profiles in tributyltin-exposed ascidians
    Kaoru Azumi
    CREST, Japan Science and Technology Corporation, Tokyo, Japan
    Mar Environ Res 58:543-6. 2004
    To analyze global gene expressions, we constructed a cDNA microarray from a basal chordate, the ascidian Ciona intestinalis. Ciona is a cosmopolitan species and a genomic analysis of Ciona revealed that ascidians had approximately 15,500 ..
  76. ncbi Ciona intestinalis: chordate development made simple
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Dev Dyn 233:1-19. 2005
    ..Recently, ascidians have entered the postgenomic era, with the sequencing of the Ciona intestinalis genome and the accumulation of molecular resources that rival those available for fruit flies and mice...
  77. ncbi Microarray analysis of zygotic expression of transcription factor genes and cell signaling molecule genes in early Ciona intestinalis embryos
    Makoto Hamaguchi
    Department of Zoology, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Dev Growth Differ 49:27-37. 2007
    ..factor genes and 25 signaling molecule genes commence their zygotic expression by the 64-cell stage of Ciona intestinalis embryos...
  78. ncbi Neurons of the ascidian larval nervous system in Ciona intestinalis: I. Central nervous system
    Janice H Imai
    Department of Biology, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    J Comp Neurol 501:316-34. 2007
    ..The caudal nerve cord contained the first reported neurons, the somata of planate neurons. These neurons are the first identified types, and will be used to construct a map of the nervous system for this model basal chordate...
  79. ncbi Functional proteomics in Ciona intestinalis: a breakthrough in the exploration of the molecular and cellular mechanism of ascidian development
    Kazuo Inaba
    Shimoda Marine Research Center, University of Tsukuba, Shizuoka, Japan
    Dev Dyn 236:1782-9. 2007
    ..Recent progress in the genome sequencing of Ciona intestinalis has led to the development of a great tool for investigating the gene functions and expressions involved in ..
  80. pmc Ascidians: an invertebrate chordate model to study Alzheimer's disease pathogenesis
    Michael J Virata
    Center for Applied and Experimental Genomics, San Diego State University, 5500 Campanile Drive, San Diego, California 92182 4614, USA
    Dis Model Mech 3:377-85. 2010
    Here we present the ascidian Ciona intestinalis as an alternative invertebrate system to study Alzheimer's disease (AD) pathogenesis...
  81. ncbi Evidence for the regulation of left-right asymmetry in Ciona intestinalis by ion flux
    Sebastian M Shimeld
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Dev Dyn 235:1543-53. 2006
    ..Vertebrates share the chordate phylum with urochordates such as the sea squirt Ciona intestinalis. We have explored the role of ion flux in regulating left-right asymmetry in Ciona, using an assay in which ..
  82. doi Drosophila P transposons of the urochordata Ciona intestinalis
    Stefanie Kimbacher
    Laboratory of Microbiology, Molecular Biology and Virology MMV, Centre of Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
    Mol Genet Genomics 282:165-72. 2009
    ..We present the P elements Pcin1, Pcin2 and Pcin3 from Ciona intestinalis, a species of the most primitive chordates, and compare them with those from Ciona savignyi...
  83. pmc Evidence that talin alternative splice variants from Ciona intestinalis have different roles in cell adhesion
    Richard H Singiser
    University of Kentucky College of Medicine, Department of Molecular and Cellular Biochemistry, 741 South Limestone Street, Lexington, KY 40536, USA
    BMC Cell Biol 7:40. 2006
    ..The nonvertebrate chordate Ciona intestinalis has only one talin gene, but alternative splicing of the talin mRNA produces two proteins with different C-..
  84. ncbi Evolutionary origins of the endocannabinoid system
    John M McPartland
    GW Pharmaceuticals, 53 Washington Street Ext, Middlebury, VT 05753, USA
    Gene 370:64-74. 2006
    ..in the genomes of twelve phylogenetically diverse organisms: Homo sapiens, Mus musculus, Takifugu rubripes, Ciona intestinalis, Caenorhabditis elegans, Drosophila melanogaster, Saccharomyces cerevisiae, Arabidopsis thaliana, Plasmodium ..
  85. ncbi Inducible lectins with galectin properties and human IL1alpha epitopes opsonize yeast during the inflammatory response of the ascidian Ciona intestinalis
    Nicolo Parrinello
    Dipartimento di Biologia Animale, Universita di Palermo, Via Archirafi 18, 90123, Palermo, Italy
    Cell Tissue Res 329:379-90. 2007
    ..Here, we show that the levels of opsonins, with IL1alpha-epitopes, increase in Ciona intestinalis hemolymph as a response to an inflammatory stimulus and, in particular, to intratunic injection of ..
  86. doi Phylogenetic conservation of cytostatic factor related genes in the ascidian Ciona intestinalis
    Gian Luigi Russo
    Stazione Zoologica Anton Dohrn, 80121, Napoli, Italy
    Gene 429:104-11. 2009
    ..Recently, we proposed the oocytes of ascidian Ciona intestinalis as a new model to study the meiotic division. Here, taking advantage of the recent publication of the C...
  87. doi Screening of ovarian steroidogenic pathway in Ciona intestinalis and its modulation after tributyltin exposure
    Maria Vittoria Cangialosi
    Department of Animal Biology G Reverberi, University of Palermo, Italy
    Toxicol Appl Pharmacol 245:124-33. 2010
    ..In addition, these results suggest that Cionaintestinalis may be a suitable species for molecular ecotoxicological studies and biomarker model for endocrine-disrupting effects in marine invertebrates...
  88. ncbi Calcitonin in a protochordate, Ciona intestinalis--the prototype of the vertebrate calcitonin/calcitonin gene-related peptide superfamily
    Toshio Sekiguchi
    Suntory Institute for Bioorganic Research, Osaka, Japan
    FEBS J 276:4437-47. 2009
    ..In this study, we have identified an authentic invertebrate CT, Ci-CT, in the ascidian Ciona intestinalis, which is the phylogenetically closest invertebrate chordate to vertebrates...
  89. pmc Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineage
    R P Tucker
    Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA 95616, USA
    BMC Evol Biol 6:60. 2006
    ..other, as well as to clarify the nomenclature used to describe them, the tenascin genes of the urochordate Ciona intestinalis, the pufferfish Tetraodon nigroviridis and Takifugu rubripes and the frog Xenopus tropicalis were identified ..
  90. ncbi Neurons of the ascidian larval nervous system in Ciona intestinalis: II. Peripheral nervous system
    Janice H Imai
    Department of Biology, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    J Comp Neurol 501:335-52. 2007
    ..Precleavage embryos of Ciona intestinalis transfected with the promoter of the neuron-specific synaptotagmin gene fused to a green fluorescent protein ..
  91. doi Trunk lateral cells are neural crest-like cells in the ascidian Ciona intestinalis: insights into the ancestry and evolution of the neural crest
    William R Jeffery
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Dev Biol 324:152-60. 2008
    ..origin, migratory activity, and neural crest related gene expression patterns of NCLC in the ascidian Ciona intestinalis. HNK-1 expression first appeared at about the time of larval hatching in dorsal cells of the posterior trunk...
  92. ncbi Sensitization and habituation of the swimming behavior in ascidian larvae to light
    Motoyuki Tsuda
    Department of Life Science, Graduate School of Science, Himeji Institute of Technology, 3 2 1 Kouto, Kamigori, Ako gun, Hyogo, Japan
    Zoolog Sci 20:13-22. 2003
    Ascidian larvae of Ciona intestinalis change their photic behavior during the course of development. Newly hatched larvae show no response to a light stimulus at any intensity...
  93. pmc High-throughput sequence analysis of Ciona intestinalis SL trans-spliced mRNAs: alternative expression modes and gene function correlates
    Jun Matsumoto
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    Genome Res 20:636-45. 2010
    ..We carried out a high-throughput analysis of the SL trans-spliced mRNA population of the ascidian tunicate Ciona intestinalis by 454 Life Sciences (Roche) pyrosequencing of SL-PCR-amplified random-primed reverse transcripts of tailbud ..
  94. ncbi Muscle development and lineage-specific expression of CiMDF, the MyoD-family gene of Ciona intestinalis
    Thomas H Meedel
    Biology Department, Rhode Island College, 600 Mt Pleasant Avenue, Providence, RI 02908, USA
    Dev Biol 241:238-46. 2002
    The expression pattern of CiMDF, the MyoD-family gene of Ciona intestinalis, was analyzed in unmanipulated and microsurgically derived partial embryos...
  95. ncbi A zinc finger transcription factor, ZicL, is a direct activator of Brachyury in the notochord specification of Ciona intestinalis
    Kasumi Yagi
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 131:1279-88. 2004
    ..These results provide evidence that ZicL directly activates Brachyury, leading to specification and subsequent differentiation of notochord cells...
  96. ncbi Comparative toxicity of alternative antifouling biocides on embryos and larvae of marine invertebrates
    Juan Bellas
    Departamento de Ecoloxia e Bioloxia Animal, Universidade de Vigo, Estrada, Colexio Universitario s n, 36310 Vigo, Galicia, Spain
    Sci Total Environ 367:573-85. 2006
    ..with embryos and larvae of the bivalve Mytilus edulis, the sea-urchin Paracentrotus lividus and the ascidian Ciona intestinalis. Toxicity was quantified in terms of the EC50 (median effective concentration) and EC10 reducing ..
  97. pmc Diploid genome reconstruction of Ciona intestinalis and comparative analysis with Ciona savignyi
    Jong Hyun Kim
    Department of Computer Science, Yonsei University, Seoul, Republic of Korea
    Genome Res 17:1101-10. 2007
    ..study, we seek to infer haplotypes, a diploid consensus sequence, from the genome assembly of an organism, Ciona intestinalis. The Ciona intestinalis genome is an ideal resource from which haplotypes can be inferred because of the ..
  98. doi The prophenoloxidase system is activated during the tunic inflammatory reaction of Ciona intestinalis
    M Cammarata
    Marine Immunobiology Laboratory, Department of Animal Biology, University of Palermo, Palermo, Italy
    Cell Tissue Res 333:481-92. 2008
    Phenoloxidase (PO) activity was examined in the tunic tissue of Ciona intestinalis following lipopolysaccharide (LPS) intratunic injection...
  99. ncbi The single nuclear lamin of Caenorhabditis elegans forms in vitro stable intermediate filaments and paracrystals with a reduced axial periodicity
    Anton Karabinos
    Max Planck Institute for Biophysical Chemistry, Department of Biochemistry, Am Fassberg 11, 37077 Gottingen, Germany
    J Mol Biol 325:241-7. 2003
    The lamins of the tunicate Ciona intestinalis and the nematode Caenorhabditis elegans show unusual sequence features when compared to the more than 35 metazoan lamin sequences currently known...
  100. ncbi Cadmium accumulation and Cd-binding proteins in marine invertebrates--a radiotracer study
    Marijana Erk
    Ruder Boskovic Institute, Center for Marine and Environmental Research, P O Box 180, Bijenicka c 54, HR 10002 Zagreb, Croatia
    Chemosphere 61:1651-64. 2005
    ..were studied in different tissues of three marine invertebrates (blue mussel Mytilus edulis, the tunicate Ciona intestinalis and the sea star Asterias rubens) using radioactive 109Cd as a tracer. The organisms were exposed to 0...
  101. ncbi Ci-FoxA-a is the earliest zygotic determinant of the ascidian anterior ectoderm and directly activates Ci-sFRP1/5
    Clement Lamy
    Institut de Biologie du Developpement de Marseille, UMR 6216, CNRS Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, F 13288 Marseille Cedex 9, France
    Development 133:2835-44. 2006
    This work focuses on the anteroposterior patterning of the ectoderm in the invertebrate chordate Ciona intestinalis. Previous work indicated that, by the eight-cell stage, the anterior and posterior animal blastomeres have acquired ..

Research Grants30

  1. Michael S Levine; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): We propose to use the sea squirt, Ciona intestinalis, as a simple chordate model to study key vertebrate developmental processes...
  2. William R Jeffery; Fiscal Year: 2014
    ..This proposal develops the tunicate Ciona intestinalis as a chordate model for studying the effects of aging on tissue regeneration...
  3. NEUROANATOMY OF THE ASCIDIAN LARVA--A CHORDATE MODEL
    J Whittaker; Fiscal Year: 1993
    ..The project will begin to investigate the neuroanatomy of the Ciona intestinalis larva, structural similarities in the CNS between individuals, and possible premetamorphic changes in the ..
  4. Lionel Christiaen; Fiscal Year: 2016
    ..To this aim, the simplified embryos of a chordate species, the ascidian Ciona intestinalis, will be used to study the migration of pre-cardiac mesoderm cells, called "trunk ventral cells" (TVCs)...
  5. Functional Conservation of Myogenic Regulatory Factors
    Thomas H Meedel; Fiscal Year: 2010
    ..This project uses embryos of the ascidian, Ciona intestinalis, as a simple in vivo test system to investigate the properties of MRF genes. We plan two approaches...
  6. Lionel Christiaen; Fiscal Year: 2016
    ..A simple chordate model system, the tunicate Ciona intestinalis, will be used to analyze the cellular and molecular mechanisms that determine muscle-type specification in ..
  7. Stephanie E Gline; Fiscal Year: 2014
    ..Combining cellular simplicity and abundance of molecular tools, Ciona intestinalis is a unique chordate model to study the molecular basis of cell migration...
  8. FUNCTION OF ELECTRICAL COUPLING IN EMBRYONIC TISSUE
    Michael Bennett; Fiscal Year: 1991
    The tunicate embryo, which proceeds from fertilization to swimming larva in about 18 hours (in the case of Ciona intestinalis), provides a remarkable preparation for the study of the role of intercellular communication in development...
  9. Anna Di Gregorio; Fiscal Year: 2015
    ..We use the basal chordate Ciona intestinalis (sea squirt), a simple yet informative vertebrate relative, as an accessible, fast-developing model system ..
  10. Regulation of cardiac myocyte proliferation and myocardial regeneration in Ciona
    Heather J Evans Anderson; Fiscal Year: 2010
    ..However, Ciona intestinalis is an invertebrate animal model system that is well characterized and has many advantages for the study of ..
  11. EDUARDO A PEROZO; Fiscal Year: 2016
    ..In addition, we will focus our attention on the voltage sensing domain from the Ciona intestinalis-Voltage-Sensor-containing Phosphatase (Ci-VSP) and the hyperpolarization-activated six-transmembrane segment ..
  12. Signaling pathways in early heart development
    BRADLEY J DAVIDSON; Fiscal Year: 2012
    ..We have begun to exploit the simplicity of Ciona intestinalis, a close evolutionary relative of the vertebrates, to investigate a conserved role for FGF in early heart ..
  13. Fundamental regulation of chordate heart development
    Bradley Davidson; Fiscal Year: 2005
    This research proposal focuses on elucidating heart developmental genetics in the primitive chordate Ciona intestinalis. Initial efforts will focus on the regulation and function of the single Ciona ortholog to the vertebrate Nkx 2...
  14. Comparative Genomic Resources for CV Research
    Edward Rubin; Fiscal Year: 2007
    ..in the human genome identified by cross-species sequence comparisons in genetically engineered mice and Ciona intestinalis and 5) clinical resequencing projects to examine a large set of candidate genes potentially causing sporadic ..
  15. MATERNAL MRNA LOCALIZATIONS IN A DETERMINATE EGG
    WILLIAM JEFFERY; Fiscal Year: 2002
    ..This investigation will provide new information on the regulation of cell division and cell fate determination during embryogenesis. ..
  16. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  17. DISRUPTION AND EXPRESSION OF MAST CELL PROTEASE GENES
    Richard Stevens; Fiscal Year: 2002
    ..Finally, the recombinant tryptases will be used to obtain low molecular weight inhibitors that are specific for each protease. ..
  18. NEUROTROPHIN RECEPTOR INTERACTIONS
    Mark Bothwell; Fiscal Year: 2004
    ..The patterns of developmental expression of P75/NTR, NRH1 and NRH2 will be examined in Xenopus and mice, to assess whether the opportunity for functional interactions exist. ..
  19. Brachyury-downstream gene networks in the notochord
    Anna Di Gregorio; Fiscal Year: 2010
    ..We have exploited the experimental advantages offered by the ascidian Ciona intestinalis as a model system to isolate and characterize a collection of notochord enhancers from genes that have ..
  20. Acetylcholinesterase: A Comparative Biochemical Approach
    Leo Pezzementi; Fiscal Year: 2005
    ..abstract_text> ..
  21. RasGRP4-dependent Responses in Mast Cells
    Richard Stevens; Fiscal Year: 2009
    ..It also is anticipated that targeted disruption of RasGRP4 expression and/or activity in humans using pharmaceutical and other approaches will be beneficial in MC-dependent disorders. ..
  22. Nogo Receptor Signaling and Function
    Mark Bothwell; Fiscal Year: 2007
    ..Effects of these manipulations on axonal targeting will be assessed by injecting the fluorescent marker Dil into embryos to allow microscopic imaging of axon trajectories. ..
  23. Amyloid Precursor Protein Signaling
    Mark Bothwell; Fiscal Year: 2006
    ..Effects of agonistic APP monoclonal antibody, beta-amyloid peptide, LRP, and alpha-2 macroglobulin on APP signaling will be assessed. ..
  24. Dual Oxidases (Duox): Enzymology & Biological Function
    J Lambeth; Fiscal Year: 2006
    ..Because ECM is a critical determinant of transformation Duox enzymes may play an important role in cancer biology in some tissues. ..
  25. Characterization of the flexible portions of fibrinogen
    Russell Doolittle; Fiscal Year: 2007
    ..These studies are aimed at determining the degree of specificity involved in the assembly of fibrin units and protofibrils as well as the relative locations of the regions involved. ..
  26. STRUCTURAL STUDIES ON FIBRINOGEN AND FIBRIN
    Russell Doolittle; Fiscal Year: 2003
    ..Combined with the full structures of the native molecules at high resolution, these results should dispel much of the mystery of fibrin formation. ..
  27. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  28. Molecular Physiology of Voltage-gated Ion Channels
    Richard Horn; Fiscal Year: 2009
    ..The proposed studies should help in the design of therapeutic drugs to treat a variety of malfunctions in excitability. ..
  29. Mechanism of cytochrome P450 uncoupling and inactivation
    JARED GOLDSTONE; Fiscal Year: 2005
    ..Recently identified AhR-agonistic persistent pollutants, such as polybrominated diphenyl ethers will also be investigated. ..
  30. Molecular Physiology of Voltage gated Ion Channels
    Richard Horn; Fiscal Year: 2005
    ..The goals are to determine orientations of voltage sensors and gates with respect to surrounding regions of the channel and to see how these orientations change in response to changes of membrane potential. ..

Patents45

  1. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
    Patent Number: JP2016507218-A; Date:2016-03-10
  2. METHOD FOR THE PRODUCTION OF MULTIPLY-UNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS
    Patent Number: JP2014128269-A; Date:2014-07-10
  3. PROCESSES FOR PRODUCING LIPIDS
    Patent Number: JP2015511118-A; Date:2015-04-16
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