Genomes and Genes
Alias: nematode, Caenorhabditis elegans (Maupas, 1900), Rhabditis elegans, Rhabditis elegans Maupas, 1900
Publications417 found, 100 shown here
- IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAMarcella Calfon
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Nature 415:92-6. 2002..that mutations in either ire-1 or the transcription-factor-encoding xbp-1 gene abolished the UPR in Caenorhabditis elegans. Mammalian XBP-1 is essential for immunoglobulin secretion and development of plasma cells, and high ..
- The genetics of Caenorhabditis elegansS Brenner
Genetics 77:71-94. 1974Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm...
- The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14R C Lee
Harvard University, Department of Cellular and Developmental Biology, Cambridge, Massachusetts 02138
Cell 75:843-54. 1993..elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin-4 regulates lin-14 translation via an antisense RNA-RNA interaction...
- Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansA Fire
Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
Nature 391:806-11. 1998..RNA interference has been used in the nematode Caenorhabditis elegans to manipulate gene expression...
- The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansB J Reinhart
Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
Nature 403:901-6. 2000..We propose that the sequential stage-specific expression of the lin-4 and let-7 regulatory RNAs triggers transitions in the complement of heterochronic regulatory proteins to coordinate developmental timing...
- Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNAA E Pasquinelli
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Nature 408:86-9. 2000Two small RNAs regulate the timing of Caenorhabditis elegans development...
- Opposing activities protect against age-onset proteotoxicityEhud Cohen
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 313:1604-10. 2006..Aggregation-mediated Abeta(1-42) toxicity was reduced in Caenorhabditis elegans when aging was slowed by decreased insulin/insulin growth factor-1-like signaling (IIS)...
- Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegansH A Tissenbaum
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Nature 410:227-30. 2001In Caenorhabditis elegans, mutations that reduce the activity of an insulin-like receptor (daf-2) or a phosphatidylinositol-3-OH kinase (age-1) favour entry into the dauer state during larval development and extend lifespan in adults...
- A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life spanMaria K Lehtinen
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Cell 125:987-1001. 2006....
- Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegansRyan Doonan
Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
Genes Dev 22:3236-41. 2008..We tested the impact of each SOD isoform in Caenorhabditis elegans by manipulating its five sod genes and saw no major effects on life span...
- Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegansB Wightman
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
Cell 75:855-62. 1993..These data suggest a molecular mechanism for Lin-14p temporal gradient formation: the lin-4 RNAs base pair to sites in the lin-14 3'UTR to form multiple RNA duplexes that down-regulate lin-14 translation...
- The cell-non-autonomous nature of electron transport chain-mediated longevityJenni Durieux
The Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Cell 144:79-91. 2011..These results suggest that mitochondria may establish and perpetuate the rate of aging for the whole organism independent of cell-autonomous functions...
- Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signalingK Lin
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA
Nat Genet 28:139-45. 2001The lifespan of Caenorhabditis elegans is regulated by the insulin/insulin-like growth factor (IGF)-1 receptor homolog DAF-2, which signals through a conserved phosphatidylinositol 3-kinase (PI 3-kinase)/Akt pathway...
- daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegansS T Henderson
Institute for Behavioral Genetics, University of Colorado at Boulder, Campus Box 447, Boulder, CO 80309 0447, USA
Curr Biol 11:1975-80. 2001..We suggest that changes in the subcellular localization of DAF-16 by environmental cues allows for rapid reallocation of resources in response to a changing environment at all stages of life...
- Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegansR S Kamath
Wellcome CRC Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
Genome Biol 2:RESEARCH0002. 2001In Caenorhabditis elegans, injection of double-stranded RNA (dsRNA) results in the specific inactivation of genes containing homologous sequences, a technique termed RNA-mediated interference (RNAi)...
- Lifespan extension by conditions that inhibit translation in Caenorhabditis elegansMalene Hansen
Department of Biochemistry and Biophysics, University of California, 600 16th Street, San Francisco, CA 94158, USA
Aging Cell 6:95-110. 2007..proteins, ribosomal-protein S6 kinase or translation-initiation factors increases the lifespan of Caenorhabditis elegans. These perturbations, as well as inhibition of the nutrient sensor target of rapamycin (TOR), which is ..
- Lifespan regulation by evolutionarily conserved genes essential for viabilitySean P Curran
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS Genet 3:e56. 2007..We screened 2,700 genes essential for Caenorhabditis elegans development and identified 64 genes that extend lifespan when inactivated postdevelopmentally...
- RPN-6 determines C. elegans longevity under proteotoxic stress conditionsDavid Vilchez
Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 489:263-8. 2012..We find that the forced re-investment of resources from the germ line to the soma in Caenorhabditis elegans results in elevated somatic proteasome activity, clearance of damaged proteins and increased longevity...
- Autophagy genes are essential for dauer development and life-span extension in C. elegansAlicia Melendez
Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Science 301:1387-91. 2003Both dauer formation (a stage of developmental arrest) and adult life-span in Caenorhabditis elegans are negatively regulated by insulin-like signaling, but little is known about cellular pathways that mediate these processes...
- Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulatorsPeichuan Zhang
Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, 600 16th Street, Room S312D, University of California, San Francisco, San Francisco, CA 94158 2517, USA
Cell Metab 17:85-100. 2013..These findings suggest that MDT-15-dependent intercellular signals, possibly lipid signals, can help to coordinate tissue physiology, enhance proteostasis, and extend life in response to DAF-16/FOXO activity...
- Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activationAmrita M Nargund
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Science 337:587-90. 2012..stress and communicates with the nucleus during the mitochondrial unfolded protein response (UPR(mt)) in Caenorhabditis elegans. We found that the key point of regulation is the mitochondrial import efficiency of ATFS-1...
- Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespanNataliya Libina
Department of Biochemistry and Biophysics, Mission Bay Genentech Hall, 600 16th Street, Room S312D, University of California, San Francisco, San Francisco, CA 94143, USA
Cell 115:489-502. 2003..We suggest that this network of tissue interactions and feedback regulation allows the tissues to equilibrate and fine-tune their expression of downstream genes, which, in turn, coordinates their rates of aging within the animal...
- A genome-scale resource for in vivo tag-based protein function exploration in C. elegansMihail Sarov
TransgeneOmics Unit, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
Cell 150:855-66. 2012..a genome-scale transgenic platform for in vivo expression of fluorescent- and affinity-tagged proteins in Caenorhabditis elegans under endogenous cis regulatory control...
- Processing of primary microRNAs by the Microprocessor complexAhmet M Denli
Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Nature 432:231-5. 2004..Suppression of Pasha expression in Drosophila cells or Caenorhabditis elegans interferes with pri-miRNA processing, leading to an accumulation of pri-miRNAs and a reduction in mature ..
- Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogensDanielle A Garsin
Department of Genetics, Massachusetts General Hospital, Boston, MA 02114, USA
Science 300:1921. 2003
- Two neurons mediate diet-restriction-induced longevity in C. elegansNicholas A Bishop
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nature 447:545-9. 2007..Here we show that increased longevity of diet-restricted Caenorhabditis elegans requires the transcription factor gene skn-1 acting in the ASIs, a pair of neurons in the head...
- Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegansEric L Greer
Department of Genetics, Stanford University, Stanford, CA 94305, USA
Aging Cell 8:113-27. 2009..Here we examine the genetic pathways that mediate longevity by different DR regimens in Caenorhabditis elegans. We have previously shown that the low-energy sensing AMP-activated protein kinase AMPK/aak-2 and the ..
- A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunityDennis H Kim
Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
Science 297:623-6. 2002A genetic screen for Caenorhabditis elegans mutants with enhanced susceptibility to killing by Pseudomonas aeruginosa led to the identification of two genes required for pathogen resistance: sek-1, which encodes a mitogen-activated ..
- RTEL1 maintains genomic stability by suppressing homologous recombinationLouise J Barber
DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
Cell 135:261-71. 2008..We propose that loss of HR control after deregulation of RTEL1 may be a critical event that drives genome instability and cancer...
- Sirtuin activators mimic caloric restriction and delay ageing in metazoansJason G Wood
Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 430:686-9. 2004..Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity...
- Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegansDaniel L Motola
Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Cell 124:1209-23. 2006....
- Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulatorJi Li
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
PLoS Biol 6:e233. 2008..We report that the Caenorhabditis elegans homolog of host cell factor 1 (HCF-1) represents a new longevity modulator and functions as a negative ..
- Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegansColin C Conine
The Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01606, USA
Proc Natl Acad Sci U S A 107:3588-93. 2010Gametogenesis is a thermosensitive process in numerous metazoans, ranging from worms to man. In Caenorhabditis elegans, a variety of RNA-binding proteins that associate with germ-line nuage (P granules), including the Piwi-clade argonaute ..
- Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegansJeremy M Van Raamsdonk
Department of Biology, McGill University, Montreal, Quebec, Canada
PLoS Genet 5:e1000361. 2009..In this experiment, we examine the effect of eliminating each of the five individual sod genes present in Caenorhabditis elegans. In contrast to what is observed in other model organisms, none of the sod deletion mutants shows ..
- Direct conversion of C. elegans germ cells into specific neuron typesBaris Tursun
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
Science 331:304-8. 2011..Through the ectopic expression of single Caenorhabditis elegans transcription factors, we found that the identity of mitotic germ cells can be directly converted into ..
- Functional interaction between beta-catenin and FOXO in oxidative stress signalingMarieke A G Essers
Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
Science 308:1181-4. 2005..beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells. In Caenorhabditis elegans, loss of the beta-catenin BAR-1 reduces the activity of the FOXO ortholog DAF-16 in dauer formation and ..
- Identification and characterization of the vesicular GABA transporterS L McIntire
Graduate Programs in Neuroscience, Cell Biology and Biomedical Sciences, Department of Neurology, UCSF School of Medicine, San Francisco, California 94143 0435, USA
Nature 389:870-6. 1997..Studies in the nematode Caenorhabditis elegans have implicated the gene unc-47 in the release of GABA...
- Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegansL Timmons
Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
Gene 263:103-12. 2001..mediated by double-stranded RNA (RNAi) has been a valuable tool in the analysis of gene function in Caenorhabditis elegans. Here we report an efficient induction of RNAi using bacteria to deliver double-stranded RNA...
- A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNAG Hutvagner
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Science 293:834-8. 2001The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals...
- TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxOStacey Robida-Stubbs
Joslin Diabetes Center, Harvard Stem Cell Institute, and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA
Cell Metab 15:713-24. 2012..We conclude that modulation of SKN-1/Nrf and DAF-16/FoxO may be generally important in the effects of TOR signaling in vivo and that these transcription factors mediate an opposing relationship between growth signals and longevity...
- Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegansSakiko Honjoh
Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto, 606 8502, Japan
Nature 457:726-30. 2009..Here we establish an IF regimen that effectively extends the lifespan of Caenorhabditis elegans, and show that the low molecular weight GTPase RHEB-1 has a dual role in lifespan regulation; RHEB-1 is ..
- Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4Shiqian Qi
Ministry of Education Protein Science Laboratory, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
Cell 141:446-57. 2010The CED-4 homo-oligomer or apoptosome is required for initiation of programmed cell death in Caenorhabditis elegans by facilitating autocatalytic activation of the CED-3 caspase zymogen...
- Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegansH Komatsu
Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
Neuron 17:707-18. 1996..The results suggest that a cyclic nucleotide-gated channel is required for thermosensation and chemosensation and that cGMP is an important intracellular messenger in C. elegans sensory transduction...
- The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life spanKailiang Jia
Molecular Biology Program and Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
Development 131:3897-906. 2004..This is a new mechanism that regulates the TOR pathway. Thus, DAF-2 insulin/IGF signaling and nutrient signaling converge on DAF-15 (raptor) to regulate C. elegans larval development, metabolism and life span...
- C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylationA C Epstein
The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
Cell 107:43-54. 2001....
- An integrated stress response regulates amino acid metabolism and resistance to oxidative stressHeather P Harding
Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
Mol Cell 11:619-33. 2003..A signaling pathway initiated by eIF2alpha phosphorylation protects cells against metabolic consequences of ER oxidation by promoting the linked processes of amino acid sufficiency and resistance to oxidative stress...
- The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegansJavier Apfeld
Elixir Pharmaceuticals, Cambridge, Massachusetts 02139, USA
Genes Dev 18:3004-9. 2004..We find that the AMP:ATP ratio, a measure of energy levels, increases with age in Caenorhabditis elegans and can be used to predict life expectancy. The C...
- A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegansWen Yang
Department of Biology, McGill University, Montreal, Quebec, Canada
PLoS Biol 8:e1000556. 2010..This model provides a new explanation for the well-documented correlation between ROS and the aged phenotype as a gradual increase of molecular damage during aging would trigger a gradually stronger ROS response...
- The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNAE G Moss
Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA
Cell 88:637-46. 1997..Deleting the LCE produces a dominant gain-of-function allele that causes a retarded phenotype, indicating that lin-28 activity is a switch that controls choices of stage-specific fates...
- Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germlineWeifeng Gu
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01606, USA
Mol Cell 36:231-44. 2009..These findings broaden our understanding of the biogenesis and diversity of 22G-RNAs and suggest additional regulatory functions for small RNAs...
- RTEL-1 enforces meiotic crossover interference and homeostasisJillian L Youds
DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms, EN6 3LD, UK
Science 327:1254-8. 2010..CO formation is controlled in part during meiotic double-strand break (DSB) creation in Caenorhabditis elegans, but a second level of control must also exist because meiotic DSBs outnumber COs...
- Raptor, a binding partner of target of rapamycin (TOR), mediates TOR actionKenta Hara
Biosignal Research Center, Kobe University, 657 8501, Kobe, Japan
Cell 110:177-89. 2002..elegans raptor yields an array of phenotypes that closely resemble those produced by inactivation of Ce-TOR. Thus, raptor is an essential scaffold for the mTOR-catalyzed phosphorylation of 4EBP1 and mediates TOR action in vivo...
- The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegansE M Hedgecock
Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110
Neuron 4:61-85. 1990Three known genes guide circumferential migrations of pioneer axons and mesodermal cells on the nematode body wall...
- An extensive class of small RNAs in Caenorhabditis elegansR C Lee
Dartmouth Medical School, Department of Genetics, Hanover, NH 03755, USA
Science 294:862-4. 2001..lin-4 and let-7 antisense RNAs are temporal regulators that control the timing of developmental events in Caenorhabditis elegans by inhibiting translation of target mRNAs...
- SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress responseJae Hyung An
Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 17:1882-93. 2003During the earliest stages of Caenorhabditis elegans embryogenesis, the transcription factor SKN-1 initiates development of the digestive system and other mesendodermal tissues. Postembryonic SKN-1 functions have not been elucidated...
- Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans geneW G Kelly
Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
Genetics 146:227-38. 1997In screening for embryonic-lethal mutations in Caenorhabditis elegans, we defined an essential gene (let-858) that encodes a nuclear protein rich in acidic and basic residues. We have named this product nucampholin...
- Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans developmentX Shen
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Cell 107:893-903. 2001..We propose that UPR transcriptional activation by ire-1 as well as translational attenuation by pek-1 maintain ER homeostasis. The results demonstrate that the UPR and ER homeostasis are essential for metazoan development...
- Distinct beta-catenins mediate adhesion and signalling functions in C. elegansH C Korswagen
Department of Immunology, University Medical Center Utrecht, The Netherlands
Nature 406:527-32. 2000..It also associates with cadherins to mediate adhesion. In Caenorhabditis elegans, three putative beta-catenin homologues have been identified: WRM-1, BAR-1 and HMP-2...
- Inducible antibacterial defense system in C. elegansGustavo V Mallo
Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Case 906, France
Curr Biol 12:1209-14. 2002..Essentially, nothing is known about immune responses in the nematode Caenorhabditis elegans. Using high-density cDNA microarrays, we show here that infection of C...
- Identification of the switch in early-to-late endosome transitionDmitry Poteryaev
Biozentrum, University of Basel, Klingelbergstrasse 70, Basel 4056, Switzerland
Cell 141:497-508. 2010..We demonstrate that Rab conversion is the mechanism by which proteins pass from early to late endosomes in Caenorhabditis elegans coelomocytes. Moreover, we identified SAND-1/Mon1 as the critical switch for Rab conversion in metazoa...
- Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs)Yoshishige Kimura
Department of Molecular Anatomy, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
J Biol Chem 285:22936-41. 2010..we investigated regulatory machinery of tubulin glutamylation in MT-based sensory cilia of the roundworm Caenorhabditis elegans. We found that ciliary MTs were polyglutamylated by a process requiring ttll-4...
- Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegansLouis R Lapierre
Program of Development and Aging, Del E Webb Neuroscience, Aging and Stem Cell Research Center, USA
Curr Biol 21:1507-14. 2011The cellular recycling process of autophagy is emerging as a key player in several longevity pathways in Caenorhabditis elegans. Here, we identify a role for autophagy in long-lived animals lacking a germline and show that autophagy and ..
- The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivoElliott J Hagedorn
Department of Biology, Duke University, Durham, NC 27708, USA
J Cell Biol 201:903-13. 2013..By developing live-cell imaging methods to follow anchor cell (AC) invasion in Caenorhabditis elegans, we identify F-actin-based invadopodia that breach basement membrane...
- Insulin/IGF-1-mediated longevity is marked by reduced protein metabolismGerdine J Stout
University Medical Center Utrecht, Wilhelmina Children s Hospital, Department of Molecular Cancer Research, Section Metabolic Diseases, Utrecht, The Netherlands
Mol Syst Biol 9:679. 2013..of the conserved Insulin/Insulin-like Growth Factor (IGF-1) pathway double the lifespan of the nematode Caenorhabditis elegans. This phenotype is completely suppressed by deletion of Forkhead transcription factor daf-16...
- COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossoversRayka Yokoo
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 149:75-87. 2012..COSA-1 foci serve as a unique live cell readout for investigating CO formation and CO interference...
- Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegansR F Ketting
The Hubrecht Laboratory and Center for Biomedical Genetics, Uppsalalaan 8, Utrecht, The Netherlands
Genes Dev 15:2654-9. 2001..Here we characterize the Caenorhabditis elegans ortholog of Dicer (K12H4.8; dcr-1) in vivo and in vitro. dcr-1 mutants show a defect in RNAi...
- Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegansThomas Hills
Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
J Neurosci 24:1217-25. 2004..dopaminergic and glutamatergic signaling contribute to the neural circuit controlling ARS in the nematode Caenorhabditis elegans. Ablation of dopaminergic neurons eliminated ARS behavior, as did application of the dopamine receptor ..
- Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegansAmy J MacQueen
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Cell 123:1037-50. 2005..We speculate that concentration of these activities at one region per chromosome may have coevolved with the loss of a point centromere to safeguard karyotype stability...
- Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXOJessica N Landis
Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
Dev Dyn 239:1405-12. 2010..Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output...
- Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat proteinElyse S Blum
Laboratory of Developmental Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Science 335:970-3. 2012Death is a vital developmental cell fate. In Caenorhabditis elegans, programmed death of the linker cell, which leads gonadal elongation, proceeds independently of caspases and apoptotic effectors...
- Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegansDaniel Ackerman
Institute of Healthy Aging and Department of Genetics Evolution and Environment, University College London, London, United Kingdom
PLoS Genet 8:e1002498. 2012..Iron homeostasis is therefore a critical determinant of fitness. In Caenorhabditis elegans, insulin/IGF-1 signaling (IIS) promotes growth and reproduction but limits stress resistance and lifespan ..
- Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathwayJessica J Vasale
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 107:3582-7. 2010..we show that distinct RdRPs function sequentially to produce small RNAs that target endogenous loci in Caenorhabditis elegans. We show that DCR-1, the RdRP RRF-3, and the dsRNA-binding protein RDE-4 are required for the biogenesis ..
- Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologueJesse M Gray
Howard Hughes Medical Institute and Department of Anatomy, The University of California, San Francisco, California 94143 0452, USA
Nature 430:317-22. 2004..We show here that the nematode Caenorhabditis elegans exhibits a strong behavioural preference for 5-12% oxygen, avoiding higher and lower oxygen levels...
- Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegansHitoshi Inada
Group of Molecular Neurobiology, Department of Molecular Biology, Graduate School of Science, Nagoya University, Japan
Genetics 172:2239-52. 2006The nematode Caenorhabditis elegans senses temperature primarily via the AFD thermosensory neurons in the head. The response to temperature can be observed as a behavior called thermotaxis on thermal gradients...
- The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived wormsAlfred L Fisher
Division of Geriatrics, Department of Medicine, University of California, San Francisco, 94121, USA
Aging Cell 5:127-38. 2006The orphan nuclear hormone receptor gene daf-12 in Caenorhabditis elegans plays a key role in the regulation of development and determination of adult longevity...
- An RIG-I-Like RNA helicase mediates antiviral RNAi downstream of viral siRNA biogenesis in Caenorhabditis elegansRui Lu
Department of Plant Pathology and Microbiology, University of California, Riverside, CA, USA
PLoS Pathog 5:e1000286. 2009Dicer ribonucleases of plants and invertebrate animals including Caenorhabditis elegans recognize and process a viral RNA trigger into virus-derived small interfering RNAs (siRNAs) to guide specific viral immunity by Argonaute-dependent ..
- Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegansAlexander A Soukas
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
Genes Dev 23:496-511. 2009..We identified mutations in the Caenorhabditis elegans homolog of rictor in a forward genetic screen for increased body fat...
- An essential role for XBP-1 in host protection against immune activation in C. elegansClaire E Richardson
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nature 463:1092-5. 2010..We have been studying innate immunity in the nematode Caenorhabditis elegans, having established a principal role for a conserved PMK-1 p38 mitogen-activated protein kinase (MAPK) ..
- Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegansRobert P Shivers
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS Genet 6:e1000892. 2010Innate immunity in Caenorhabditis elegans requires a conserved PMK-1 p38 mitogen-activated protein kinase (MAPK) pathway that regulates the basal and pathogen-induced expression of immune effectors...
- daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegansK D Kimura
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Science 277:942-6. 1997..Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity...
- Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans agingAnat Ben-Zvi
Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
Proc Natl Acad Sci U S A 106:14914-9. 2009..We propose that the collapse of proteostasis represents an early molecular event of aging that amplifies protein damage in age-associated diseases of protein conformation...
- Genetic control of programmed cell death in the nematode C. elegansH M Ellis
Cell 44:817-29. 1986..of the genes ced-3 and ced-4 are required for the initiation of programmed cell deaths in the nematode Caenorhabditis elegans. The reduction or loss of ced-3 or ced-4 function results in a transformation in the fates of cells that ..
- The complete family of genes encoding G proteins of Caenorhabditis elegansG Jansen
Division of Molecular Biology, The Netherlands Cancer Institute, Centre for Biomedical Genetics, Amsterdam
Nat Genet 21:414-9. 1999b>Caenorhabditis elegans is the first animal whose genomic sequence has been determined. One of the new possibilities in post-sequence genetics is the analysis of complete gene families at once...
- Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange proteins but critical for proper completion of recombinationMONICA P COLAIACOVO
Department of Developmental Biology, Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
Dev Cell 5:463-74. 2003..of the synaptonemal complex (SC) and progression of recombination between homologous chromosomes during Caenorhabditis elegans meiosis...
- Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperonesTakunari Yoneda
Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
J Cell Sci 117:4055-66. 2004..We found that the mitochondrial matrix HSP70 and HSP60 chaperones, encoded by the Caenorhabditis elegans hsp-6 and hsp-60 genes, were selectively activated by perturbations that impair assembly of multi-subunit ..
- Inhibition of mRNA translation extends lifespan in Caenorhabditis elegansKally Z Pan
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA
Aging Cell 6:111-9. 2007..in the cap-binding complex; and rsks-1, the worm homologue of S6 kinase, results in lifespan extension in Caenorhabditis elegans. Inhibition of ifg-1 or rsks-1 also slows development, reduces fecundity and increases resistance to ..
- LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteinsAisa Sakaguchi-Nakashima
Department of Molecular Biology, Graduate School of Science, Institute for Advanced Research, Nagoya University, Japan
Curr Biol 17:592-8. 2007..The transparent nematode Caenorhabditis elegans can be used to examine sorting and transport of SV proteins in vivo...
- A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life spanB Gerisch
Max Planck Institut fur Molekulare Genetik, Ihnestr 73, D 14195 Berlin, Germany
Dev Cell 1:841-51. 2001..Sensory neurons, hypodermis, and somatic gonadal cells expressing daf-9 identify potential endocrine tissues. Evidently, lipophilic hormones influence nematode metabolism, diapause, and life span.
- daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathwayWeiqing Li
Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
Genes Dev 17:844-58. 2003In Caenorhabditis elegans, the decision to enter a developmentally arrested dauer larval stage is triggered by a combination of signals from sensory neurons in response to environmental cues, which include a dauer pheromone...
- gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegansR Francis
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genetics 139:579-606. 1995We have characterized 31 mutations in the gld-1 (defective in germline development) gene of Caenorhabditis elegans. In gld-1 (null) hermaphrodites, oogenesis is abolished and a germline tumor forms where oocyte development would normally ..
- Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organizationIrini Topalidou
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
Curr Biol 22:1057-65. 2012..How these different MTs are formed is unknown, although the number of protofilaments may depend on the nature of the α- and β-tubulins...
- Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timingA Grishok
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 106:23-34. 2001..In Caenorhabditis elegans, lin-4 and let-7 encode small temporal RNAs (stRNAs) of 22 nt that regulate stage-specific development...
- Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stressTim J Schulz
Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
Cell Metab 6:280-93. 2007..We show here that increased glucose availability decreases Caenorhabditis elegans life span, while impaired glucose metabolism extends life expectancy by inducing mitochondrial respiration...
- ClpP mediates activation of a mitochondrial unfolded protein response in C. elegansCole M Haynes
Kimmel Center for Biology and Medicine of Skirball Institute and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Dev Cell 13:467-80. 2007..As ClpP is known to function in the bacterial heat-shock response, our findings suggest that eukaryotes utilize component(s) from the protomitochondrial symbiont to signal the UPR(mt)...
- Enhanced neuronal RNAi in C. elegans using SID-1Andrea Calixto
Department of Biological Sciences, Columbia University, New York, New York, USA
Nat Methods 7:554-9. 2010We expressed SID-1, a transmembrane protein from Caenorhabditis elegans that is required for systemic RNA interference (RNAi), in C. elegans neurons...
- Genome-wide analysis of GLD-1-mediated mRNA regulation suggests a role in mRNA storageClaudia Scheckel
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
PLoS Genet 8:e1002742. 2012..Unlike repression, the stabilization of these mRNAs is surprisingly little understood. A key player in Caenorhabditis elegans germ cell development is the STAR domain protein GLD-1...
- A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegansN Pujol
Laboratoire de Genetique et Physiologie du Developpement, Institut National de la Santé et de la Recherche Médicale Centre National pour la Recherche Scientifique Université de la Mediterranée, 13288, Marseille, France
Curr Biol 11:809-21. 2001..Whether such an inducible system of innate immunity is present in the model nematode Caenorhabditis elegans is currently an open question...
- Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune responseNicole T Liberati
Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 101:6593-8. 2004..We have previously shown that the Caenorhabditis elegans p38 mitogen-activated protein kinase, PMK-1, functions in an innate immune response pathway that mediates ..
- A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologueWei Li
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
Nature 440:684-7. 2006The nematode Caenorhabditis elegans is commonly used as a genetic model organism for dissecting integration of the sensory and motor systems...
- The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosisAlexandra Penkner
Department of Chromosome Biology, Max F Perutz Laboratories, University of Vienna, A 1030 Vienna, Austria
Dev Cell 12:873-85. 2007We identify a highly specific mutation (jf18) in the Caenorhabditis elegans nuclear envelope protein matefin MTF-1/SUN-1 that provides direct evidence for active involvement of the nuclear envelope in homologous chromosome pairing in C...
- Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegansEric A Evans
Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Pathog 4:e1000175. 2008..aeruginosa is able to suppress the expression of a subset of immune defense genes in the animal host Caenorhabditis elegans by activating the DAF-2/DAF-16 insulin-like signaling pathway...
- Molecular mechanisms underlying lifespan extension by dietary restrictionAnne Brunet; Fiscal Year: 2013..mechanisms by which AMPK extends lifespan A combination of genetics and biochemical approaches in Caenorhabditis elegans (C. elegans) will be used to develop these aims...
- Daniel E Martinez; Fiscal Year: 2014..treated to eliminate the stem cells which produce gametes, we will investigate the possibility that, as in Caenorhabditis elegans and Drosophila melanogaster, germ cells in H. oligactis can reduce lifespan...
- Scott Pletcher; Fiscal Year: 2016..Indeed, evidence from work in the nematode, Caenorhabditis elegans, and from our work in the fruit fly, Drosophila melanogaster, has established that aging is strongly ..
- Novel models for longevity researchChristian Sell; Fiscal Year: 2012..Whereas single mutations in the IGF-I receptor and signaling pathways impart lifespan extension in Caenorhabditis elegans and Drosophila melanogaster, the most robust examples of lifespan extension in mammals are associated with ..
- Whole genome screen for novel regulators of tissue homeostasis and regenerationMARK DOUGLAS YANDELL; Fiscal Year: 2013..of choice for addressing research questions that cannot be easily studied in Drosophila melanogaster or Caenorhabditis elegans, including wound healing of adult tissues, regeneration, somatic stem cells, and tissue homeostasis...
- Ai Ling Lin; Fiscal Year: 2016..well-studied one for various model organisms of extended longevity, including Saccharomyces cerevisiae, Caenorhabditis elegans, rodents and monkeys...
- CONTROL OF EUCARYOTIC FUNCTION BY METHYLATIONSteven G Clarke; Fiscal Year: 2013..Here, we will utilize both mouse and worm (Caenorhabditis elegans) systems to explore the relationships between the accumulation of age-damaged proteins, their recognition ..
- Analysis of Protein Dynamics in C. elegans by mLC/MS/MSMichael MacCoss; Fiscal Year: 2013..turnover and the importance of insulin signaling, we propose to study both these processes in the nematode Caenorhabditis elegans using quantitative proteornics...
- Kurt W Runge; Fiscal Year: 2014..that cells lacking the ATP2 gene had a short lifespan, which was surprising since RNAi experiments in Caenorhabditis elegans indicated that reducing expression of other F1F0- ATP synthase subunits extends lifespan...
- MENG CARLA WANG; Fiscal Year: 2016..During the preliminary studies, we characterized LIPL-4 as a lysosomal acid lipase in Caenorhabditis elegans. Its constitute expression in the fat storage tissue induces lipolysis as well as prolongs organism ..
- Matt Kaeberlein; Fiscal Year: 2015..the hypoxic response transcription factor, HIF-1, as a novel modifier of longevity and healthspan in Caenorhabditis elegans. In a study published in the journal Science, we showed that stabilization of HIF-1 by inhibiting its ..
- Dennis H Kim; Fiscal Year: 2016..motivating me to embark on the molecular genetic analysis of innate immunity in the simple host organism Caenorhabditis elegans. The long-term goal of this project is to understand the molecular mechanisms of host defense in C...
- Daniel Kalman; Fiscal Year: 2016..provided by applicant): In this proposal, we describe experiments to identify and characterize how the Caenorhabditis elegans innate immune and longevity pathways contribute to protection from bacterial pathogens, particularly ..
- Matt Kaeberlein; Fiscal Year: 2015..scale in the budding yeast Saccharomyces cerevisiae, second to extend these findings to the nematode Caenorhabditis elegans, and third to begin identification and testing of human functional variants corresponding to factors ..
- SUZANNE ELIZABETH BEREZOVSKY; Fiscal Year: 2014..to high doses in the budding yeast Saccharomyces cerevisiae, cause lifespan extension in the worm Caenorhabditis elegans, and protect mice against brain damage in a model of stroke...
- Tina L Gumienny; Fiscal Year: 2015..We are using the genetic tools available in Caenorhabditis elegans to investigate several outstanding questions in intercellular TGF-beta gradient formation...
- Modeling the Aging EpigenomeBruce A Yankner; Fiscal Year: 2011..We intend to use the nematode worm, Caenorhabditis elegans, to develop CI- ChIP. The genetic tractability and aging biology of the worm offers many advantages...
- Bruce A Yankner; Fiscal Year: 2014..We intend to use the nematode worm, Caenorhabditis elegans, to develop CI- ChIP. The genetic tractability and aging biology of the worm offers many advantages...
- Subcellular Analysis of Caenohabdibtis elegans Aging ModelsEdgar A Arriaga; Fiscal Year: 2012DESCRIPTION (provided by applicant): The soil nematode Caenorhabditis elegans (C. elegans) is an excellent model organism for investigating the process of aging. The Dillin group uses long-lived C...
- Time-Course Proteomics to Uncover the Mechanism and Nature of Aging in C. elegansJARRETT DAVID EGERTSON; Fiscal Year: 2013..This project aims to enhance understanding of the aging process through the study of the long-lived Caenorhabditis elegans daf-2 mutant...
- Microfluidic-microtiter interface for rapid large-scale screenings of C. elegansAdela Ben Yakar; Fiscal Year: 2010..Among these animals, the nematode Caenorhabditis elegans (C. elegans) is one of the most powerful model organisms providing a wide-range of genetic tools...
- Marc R Van Gilst; Fiscal Year: 2016..the genetic and molecular basis of life span extension and disease prevention from DR in the nematode Caenorhabditis elegans. These studies are likely to be highly relevant for human health and will identify candidate genetic ..
- Roles of Lipid Metabolism in Regulation of LongevityMENG CARLA WANG; Fiscal Year: 2013..suggested that lipases and lipid chaperones exert exquisite control over lipid metabolism and lifespan in Caenorhabditis elegans. Lipases and lipid chaperones are up-regulated in long-lived animals, and necessary for their longevity...
- Alexander A Soukas; Fiscal Year: 2014..Discovery of obesity and diabetes candidate genes will help both to inform future study of metabolic diseases and to design intelligent therapies to combat these devastating diseases. ..
- An experimental model for stochastic biodemographyPatrick C Phillips; Fiscal Year: 2013..The model nematode Caenorhabditis elegans is especially amenable to addressing these problems because it has become a central player in ..
- Investigation of Anaphase Promoting Complex function in synaptic transmissionJennifer Kowalski; Fiscal Year: 2012..This will be done using the model nematode, Caenorhabditis elegans, which shares significant conservation of nervous system proteins and function with humans...
- Using shared mechanisms of morphogenesis to study neural tube defectsJESSICA LEE SULLIVAN-BROWN; Fiscal Year: 2012..Gastrulation in the nematode, Caenorhabditis elegans (C...
- The functional role of DRH-1 in RNAi directed viral immunityRui Lu; Fiscal Year: 2013..DRH-1 is a putative RNA helicase conserved in both the Caenorhabditis elegans (C .elegans) nematode and mammals...
- Identifying New Aging and Longevity Genes in Caenorhabditis elegansMuneesh Tewari; Fiscal Year: 2007..It is anticipated that the combined approach of protein interaction mapping and RNAi-based analysis will identify many new genes involved in dauer formation, aging and longevity. [unreadable] [unreadable] [unreadable]..
- Genetic dissection of the RNAi-mediated antiviral immunity in C. elegansShou Wei Ding; Fiscal Year: 2013..The proposed research will genetically dissect the immune pathway of Caenorhabditis elegans animals triggered by Flock house virus (FHV), one of the best characterized RNA viruses...
- Regulation of Systemic RNA Interference in the Nematode C. elegansJENNIFER SUNG WHANGBO; Fiscal Year: 2013..The study of systemic RNAi in the model system Caenorhabditis elegans will provide important insights for the delivery of RNAi-based therapies in humans...
- Investigating Neuroprotective Targets for Parkinson Disease Associated with AutopGuy A Caldwell; Fiscal Year: 2011..We have exploited attributes of the nematode model system, Caenorhabditis elegans, to develop assays that facilitate the screening and isolation of conserved genetic factors that mediate ..
- SALVATORE JAMES CHERRA; Fiscal Year: 2015..The roundworm, Caenorhabditis elegans, will be utilized as a model system for four main reasons: 1) its neuronal networks are formed and ..
- The genetics of gamete sex control in convergent Caenorhabditis hermaphroditesJOSEPH ANDREW ROSS; Fiscal Year: 2011..A conserved sex determination pathway in Caenorhabditis elegans and C...
- Genetic and genomic investigations of fat storage and metabolism in C. elegansJennifer L Watts; Fiscal Year: 2013..Our work in the model organism Caenorhabditis elegans has led the identification of conserved regulators of lipid homeostasis...
- Discovering buffered developmental networks underlying C. elegans embryogenesisANNALISE BLOSS PAABY; Fiscal Year: 2012..This research will characterize cryptic genetic variation for early embryogenesis in the nematode Caenorhabditis elegans. Cryptic genetic variation includes alleles that confer functional effects on phenotype, but which are ..
- Ann E Rougvie; Fiscal Year: 2016..overall objective of the Caenorhabditis Genetics Center (CGC) is to promote research on the small metazoan Caenorhabditis elegans by acquiring, maintaining, and distributing genetically characterized nematode stocks...
- Presynaptic Mechanisms Regulating the Dopamine TransporterJAMES A HARDAWAY; Fiscal Year: 2013..In the nematode Caenorhabditis elegans, synaptic spillover of DA produced by pharmacological or genetic loss of DAT (DAT-1) induces a locomotory ..
- Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunityMICHAEL ALLEN RIEHLE; Fiscal Year: 2012..the ISC and its impacts on mosquito physiology and vector competence that were conceptualized for Caenorhabditis elegans, Drosophila melanogaster and mammals...
- Identifying novel anti-infectives by high through-put screening in whole animalsFrederick M Ausubel; Fiscal Year: 2013..We have developed infection models in the nematode Caenorhabditis elegans that can be used to identify drugs that cure otherwise lethal infections...
- Variable Dose Rate X-ray IrradiatorHoward B Lieberman; Fiscal Year: 2010..be undertaken on a wide array of model systems such as radioresistant yeast, Drosophila melanogaster and Caenorhabditis elegans, as well as mammalian cells in culture, or small rodents. Drs...
- Randy D Blakely; Fiscal Year: 2016..to identify and characterize novel presynaptic regulators of DA signaling using the powerful model system Caenorhabditis elegans. Over the past 15 years, the Blakely lab has developed skills in the C...
- Characterization of a novel presynaptic target for ethanol actionGREGG W ROMAN; Fiscal Year: 2012..Munc13.1 is a presynaptic active zone protein essential for neurotransmitter release in brain. In Caenorhabditis elegans, the homologous Unc13 protein is responsible for the sensitivity to volatile anesthetics...
- Meifan Chen; Fiscal Year: 2015..invertebrate dual leucine zipper-bearing kinase DLK-1/Wallenda required for the regenerative response in Caenorhabditis elegans and Drosophila melanogaster...
- Comprehensive Identification of Worm and Fly Transcription Factor Binding SitesRobert H Waterston; Fiscal Year: 2012..by the full set of transcription factors (TFs) in the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans. In the initial modENCODE project, an experimental pipeline was developed and applied to ~100 TFs in each ..
- Robert H Waterston; Fiscal Year: 2016..the vast majority of transcription factors (TFs) in the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans. In the initial modENCODE project, an experimental pipeline was developed and applied to -100 TFs in each ..
- Genome-wide profiling of histone variants in Drosophila and CaenorhabditisSteven Henikoff; Fiscal Year: 2011..We propose to map major core histone variants throughout the annotated Drosophila melanogaster and Caenorhabditis elegans genomes at high resolution...
- Mark Borodovsky; Fiscal Year: 2014..developed earlier on a smaller scale and tested on fungal and other "compact" eukaryotic genomes (such as Caenorhabditis elegans and Drosophila melanogaster) to work with most complex eukaryotic genomes...
- H Robert Horvitz; Fiscal Year: 2014DESCRIPTION (provided by applicant): The nematode Caenorhabditis elegans is an excellent organism for the study of animal development and behavior and of the ways in which mutations can disrupt development and behavior...
- New faculty recruitment for systems genetics research core centerDavid W Threadgill; Fiscal Year: 2010..a variety of research activities using multi-cellular model organisms including Arabidobsis thaliana, Caenorhabditis elegans, Drosophila melanogaster and Mus musculus...
- COPAS SELECT Embryo SorterDeborah Andrew; Fiscal Year: 2009..a COPAS Select Embryo Sorter for use in research and education in studies of Drosophila melanogaster and Caenorhabditis elegans. Historically, these organisms have had a significant impact on our understanding of human biology;a major ..
- Mechanisms of Heme Transport in MacrophagesCARINE CARINE WHITE; Fiscal Year: 2012..has identified the first eukaryotic heme importer/transporter HRG-1, using the genetic animal model Caenorhabditis elegans (Nature 2008)...
- Diverse Roles for RIC8 During G Protein Signaling in FungiKatherine A Borkovich; Fiscal Year: 2012..RIC8 is required for asymmetric cell division in both Caenorhabditis elegans and Drosophila...
- Abby F Dernburg; Fiscal Year: 2015..We study meiosis in the nematode roundworm Caenorhabditis elegans, which offers major experimental advantages, including outstanding cytology and powerful genetic tools...
- Development and Regulation of Cholinergic SynapsesAndres Villu Maricq; Fiscal Year: 2013..is to gain a mechanistic understanding of AChR-mediated synaptic signaling by using a genetic approach in Caenorhabditis elegans to identify signaling pathways that contribute to the delivery or function of a7-like AChRs...
- DAVID IRWIN GREENSTEIN; Fiscal Year: 2016..The nematode Caenorhabditis elegans has emerged as a paradigm for studying meiosis and germline proliferation and their regulation by ..
- Iqbal Hamza; Fiscal Year: 2016..We have demonstrated that the roundworm Caenorhabditis elegans is an excellent animal model to identify heme transport pathways because it synthesizes a large number of ..
- Jinghua Hu; Fiscal Year: 2016..The highly conserved ciliopathy candidates, ciliogenesis pathway, and cilia sensory function make Caenorhabditis elegans a powerful model for characterizing the physiological roles of ciliopathy genes in their native cellular ..
- Gene Networks Regulating Muscle Protein DegradationNathaniel J Szewczyk; Fiscal Year: 2010..using the simplest genetically tractable organism available for studying innervated muscle, the nematode Caenorhabditis elegans. As in human muscle, proteolysis in C...
- Design of a high-throughput screen for chemicals that cause meiotic aneuploidyPatrick Allard; Fiscal Year: 2011..a high-throughput screening approach that makes use of the remarkable biological features of the nematode Caenorhabditis elegans, which as a meiotic model system shows a high degree of conservation with humans...
- JoAnne Engebrecht; Fiscal Year: 2016..conserved mechanisms underlying chromosome behavior during male meiosis using the metazoan animal model Caenorhabditis elegans, which is particularly amenable to genetic, cell biological and molecular approaches...
- Molecular Genetic Tools for Parasitic HelminthsEdward J Pearce; Fiscal Year: 2013..Nevertheless, the free-living worm Caenorhabditis elegans and planaria can be studied using sophisticated molecular tools, suggesting that development of similar ..
- Secretory Vesicle Function During Spermatogenesis & Fertilization in C. elegansSTEVEN W L apos HERNAULT; Fiscal Year: 2010..Our preliminary data show that Caenorhabditis elegans spermatogenesis is ideally suited for analyzing the V-ATPase role and regulation during biogenesis and ..
- Dylan P Rahe; Fiscal Year: 2014..I aim in this proposal to combine the power of genetics in Caenorhabditis elegans with a reprogramming assay with proven effectiveness, which was developed in our lab, to elucidate the ..
- David H A Fitch; Fiscal Year: 2015..governing the morphogenesis of a novel, simple and sexually dimorphic model structure, the tail tip of Caenorhabditis elegans. The tail tip is composed of four cells which-in males only-radically alter their shape and position at ..
- Scott Rifkin; Fiscal Year: 2016..This project uses quantitative measurements and mathematical modeling to understand how the nematode Caenorhabditis elegans specifies endodermal cell fate...
- Maureen M Barr; Fiscal Year: 2014..The nematode Caenorhabditis elegans is a powerful model organism to study the roles of the nephrocystins in their native cellular environment...
- Michael A Miller; Fiscal Year: 2016..The objective of this application is to determine the extent to which the nematode model Caenorhabditis elegans can be used to address fundamental questions in prostaglandin biology...
- Swathi Arur; Fiscal Year: 2016..of ERK signaling results in defective oocyte maturation and perturbed trophoblast development, while in Caenorhabditis elegans loss of ERK function disrupts oocyte differentiation and maturation, leading to sterility or early ..
- Temperature control of the C. elegans circadian clockALEXANDER MARTINUS VAN DER LINDEN; Fiscal Year: 2013..has discovered for the first time circadian genes entrained by temperature cycles in the model organism Caenorhabditis elegans, establishing this animal as a new model in the clock field for studying the temperature-entrained clock(s)..
- Alejandro Aballay; Fiscal Year: 2016..Using the nematode Caenorhabditis elegans, we have recently demonstrated that innate immunity is not only regulated at the cell autonomous level, ..
- James B Lok; Fiscal Year: 2016..Drawing upon extensive relevant findings in Caenorhabditis elegans, we have uncovered definitive evidence that insulin-like (ILS) and steroid-nuclear hormone receptor (NHR) ..
- Iqbal Hamza; Fiscal Year: 2016..through cellular membranes and organelles? In the previous grant cycle, we pioneered the use of Caenorhabditis elegans, a genetic animal model which does not synthesize heme but utilizes environmental heme to manufacture ..
- LOUIS JAMES MAHER; Fiscal Year: 2016..and mammalian cells lacking SDH function, and to develop a nematode model of PGL for drug screening in Caenorhabditis elegans. Aim 1 will seek evidence for dioxygenase inhibition in primary human PGL tumor samples...
- BRUCE A BOWERMAN; Fiscal Year: 2016..to identify macromolecular interactions that influence microtubule stability and function in the nematode Caenorhabditis elegans, by finding conditional mutations in essential genes that are required for early embryonic cell division...
- JASMINE JANCOLA ALEXANDER-FLOYD; Fiscal Year: 2014..b>Caenorhabditis elegans has a physiological protective program (dauer diapause) that is known to be stress-resistant and protected ..
- PAUL WARREN STERNBERG; Fiscal Year: 2016..provided by applicant): WormBase Is the major publicly available database of information related to Caenorhabditis elegans, an important organism for basic biomedical research, and other nematodes of medical and agricultural ..
- JOSHUA SOLOMON GREENE; Fiscal Year: 2016..One such simple model system, Caenorhabditis elegans, demonstrates several social behaviors, but has only 302 neurons. C...
- ROBERT P GOLDSTEIN; Fiscal Year: 2016..This goal will be approached using Caenorhabditis elegans as a model system. Gastrulation in C...
- JOHN ANTHONY CALARCO; Fiscal Year: 2015..Here, we propose to use the Caenorhabditis elegans nervous system as a model to advance our understanding of alternative splicing regulation in vivo...
- EYLEEN JORGELINA O'ROURKE; Fiscal Year: 2015..between nutrients, fat stores, and other tissues, cannot be reduced to biochemical or cell-based assays: Caenorhabditis elegans, a roundworm sharing 50% of its genes with humans, is particularly well suited for large-scale whole ..
- LESILEE ROSE; Fiscal Year: 2015..the molecular mechanisms of spindle positioning and cytokinesis during asymmetric divisions in the Caenorhabditis elegans embryo. As in other systems, asymmetric division in the C...
- The role of cannabinoid signaling in the nematode Caenorhabditis elegansMATTHEW SIMON GILL; Fiscal Year: 2010..in many different species, including some invertebrates, but they have not been identified in the nematode Caenorhabditis elegans. In C...
- GENETICS OF NEMATODE PHARYNGEAL MUSCLE EXCITABILITYLeon Avery; Fiscal Year: 2003..molecular understanding of the function of an electrically excitable cell, the pharyngeal muscle cell of Caenorhabditis elegans. Through our past research we have developed a model describing key ion channels active at each stage of ..
- Anne E Carpenter; Fiscal Year: 2015..The worm Caenorhabditis elegans is a well-established and effective model organism, used by thousands of researchers worldwide to study ..
- Satiety signaling in Caenorhabditis elegansLeon Avery; Fiscal Year: 2013..by applicant): We propose to investigate the molecular mechanisms of appetite control in the nematode Caenorhabditis elegans. Just as in mammals, C elegans appetite is promoted by hunger signals and suppressed by satiety signals...
- Development of a genetically tractable nematode model of alphavirus infectionMargaret R Macdonald; Fiscal Year: 2010..This project will utilize the well-studied nematode Caenorhabditis elegans as a model organism for studying the role of host factors in Alphavirus replication...
- MOLECULAR GENETICS OF C. ELEGANS RNA POLYMERASE IIDONALD RIDDLE; Fiscal Year: 1990The nematode, Caenorhabditis elegans, is currently utilized as a laboratory model for a variety of biomedical research applications, including the study of metazoan development...
- NR4A Regulation of Organ MorphogenesisCHRISTOPHER GISSENDANNER; Fiscal Year: 2009..and characterize NR4A nuclear receptor pathways regulating organ morphogenesis in the model organism Caenorhabditis elegans. The NR4A nuclear receptors are a conserved, functionally diverse group of transcription factors that ..
- C elegans:a model to study intestinal water-soluble vitamins transport in vivoHAMID SAID; Fiscal Year: 2007..unreadable] DESCRIPTION (provided by applicant): The aim of this R21 proposal is to establish the nematode Caenorhabditis elegans (C...
- Lectin-Carbohydrate Interactions in the Host-Parasite SystemXiao Qiang Yu; Fiscal Year: 2010..Immulectin-2 (IML-2) directly binds to nematodes Caenorhabditis elegans and Brugia malayi, and binding of IML-2 to C. elegans stimulates melanization of the worms...
- A C.elegans high-throughput assay for the identification of new antifungal agentsEleftherios Mylonakis; Fiscal Year: 2010The main objective of this proposal is the development of automated, high-throughput, Caenorhabditis elegans-based assays that can be used to screen chemical compounds and identify those with antifungal activity...
- LAURA CATHERINE KELLEY; Fiscal Year: 2015..live-cell imaging with the highly- stereotyped and genetically tractable model of anchor cell invasion in Caenorhabditis elegans to uncover the molecular mechanisms regulating basement membrane breaching in vivo...
- GENETICS OF CAENORHABDITIS ELEGANS SPERM MORPHOGENESISSTEVEN L HERNAULT; Fiscal Year: 2003..We study the genetic control of asymmetric partitioning during Caenorhabditis elegans spermatocyte development, which offers some of the advantages of a unicellular system within a metazoan ..
- DEVELOPMENT GLYCOBIOLOGY OF CAENORHABDITIS ELEGANSRichard Cummings; Fiscal Year: 2003..the opportunity to use genetic approaches to study these potential functions is the common soil nematode Caenorhabditis elegans. C...
- RNAi Mediated Gene Disruption in Caenorhabditis ElegansWayne Van Voorhies; Fiscal Year: 2006..or manipulations that extend longevity using an intensively analyzed model organism, such as the nematode Caenorhabditis elegans. A new method for identifying genes affecting longevity in C...
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