fruit fly

Summary

Alias: Drosophila melanogaster, Drosophila melangaster, Drosophila melanogaster Meigen, 1830

Top Publications

  1. pmc Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
    Peter V Kharchenko
    Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:480-5. 2011
  2. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
  3. ncbi Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    D D Sarbassov
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 307:1098-101. 2005
  4. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
  5. pmc Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease
    Scott J Gratz
    Genetics Training Program, University of Wisconsin, Madison, Madison, WI 53706, USA
    Genetics 194:1029-35. 2013
  6. ncbi HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
    Udai Bhan Pandey
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 447:859-63. 2007
  7. ncbi Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction
    Mattias C Larsson
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 43:703-14. 2004
  8. pmc An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases
    Johannes Bischof
    Frontiers in Genetics, National Center of Competence in Research, Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:3312-7. 2007
  9. pmc MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
  10. pmc Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo
    Richard Benton
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York, USA
    PLoS Biol 4:e20. 2006

Research Grants

  1. Amita Sehgal; Fiscal Year: 2014
  2. A Systems Biology Approach To Cardiomyopathy in the D. Melanogaster Model System
    BRIAN O'ROURKE; Fiscal Year: 2013
  3. Functional and Coevolutionary Analysis of Interacting Reproductive Proteins in Dr
    GEOFFREY DAVID FINDLAY; Fiscal Year: 2013
  4. Using Drosophila as a model to understand TDP-43 function in ALS
    David B Morton; Fiscal Year: 2012
  5. Jan Lammerding; Fiscal Year: 2016
  6. Craig Montell; Fiscal Year: 2015
  7. B Jill Venton; Fiscal Year: 2016
  8. Modeling the Evolution and Function of Drosophila cis-Regulatory Modules
    MICHAEL BRUCE EISEN; Fiscal Year: 2012
  9. Zachary Freyberg; Fiscal Year: 2015
  10. William D Tracey; Fiscal Year: 2014

Patents

  1. Process for the enzymatic production of 3,4-O-dimethylated cinnamic acids, 3,4-dimethoxyphenylethylamines and 4-O-methylated cinnamic acid amides
  2. PROTEASE SCREENING METHODS AND PROTEASES IDENTIFIED THEREBY
  3. NUCLEIC ACID MOLECULE AND USES THEREOF
  4. NUCLEIC ACID MOLECULE AND USES THEREOF
  5. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
  6. Generation of Drosophila DSCR1-GAL4, and DSCR1-GAL4, UAS-GFP double mutants preparation method of manufacturing the transgenic mutants
  7. EARLY DEVELOPMENTAL GENOMIC ASSAY FOR CHARACTERIZING PLURIPOTENT STEM CELL UTILITY AND SAFETY
  8. Engineered Cells Expressing Multiple Immunomodulators and Uses Thereof
  9. GPCR Ligand Peptides and a Conserved Motif Theirof
  10. Topical Gels Containing Alpha Connexin C-Terminal (ACT) Peptides

Detail Information

Publications434 found, 100 shown here

  1. pmc Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
    Peter V Kharchenko
    Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:480-5. 2011
    ..Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns...
  2. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
    ..We have directed expression of an activated form of the Dras2 protein, resulting in dominant eye and wing defects that can be used in screens to identify other members of the Dras2 signal transduction pathway...
  3. ncbi Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    D D Sarbassov
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 307:1098-101. 2005
    ..Rictor-mTOR may serve as a drug target in tumors that have lost the expression of PTEN, a tumor suppressor that opposes Akt/PKB activation...
  4. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
    ..Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways...
  5. pmc Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease
    Scott J Gratz
    Genetics Training Program, University of Wisconsin, Madison, Madison, WI 53706, USA
    Genetics 194:1029-35. 2013
    ..This RNA-guided Cas9 system can be rapidly programmed to generate targeted alleles for probing gene function in Drosophila. ..
  6. ncbi HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
    Udai Bhan Pandey
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 447:859-63. 2007
    ..Here we show that autophagy acts as a compensatory degradation system when the UPS is impaired in Drosophila melanogaster, and that histone deacetylase 6 (HDAC6), a microtubule-associated deacetylase that interacts with ..
  7. ncbi Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction
    Mattias C Larsson
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 43:703-14. 2004
    ..Consistent with this cellular defect, the Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. Or83b therefore encodes an atypical odorant receptor that plays an essential general role in olfaction...
  8. pmc An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases
    Johannes Bischof
    Frontiers in Genetics, National Center of Competence in Research, Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 104:3312-7. 2007
    Germ-line transformation via transposable elements is a powerful tool to study gene function in Drosophila melanogaster. However, some inherent characteristics of transposon-mediated transgenesis limit its use for transgene analysis...
  9. pmc MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
    ..and characterization of the first few target genes regulated by miRNAs in Caenorhabditis elegans and Drosophila melanogaster have set the stage for elucidation of a novel network of regulatory control...
  10. pmc Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo
    Richard Benton
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York, USA
    PLoS Biol 4:e20. 2006
    ....
  11. pmc Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
    J Graham Ruby
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Genome Res 17:1850-64. 2007
    ..to predict miRNAs conserved among Drosophila species and large-scale sequencing of small RNAs from Drosophila melanogaster to experimentally confirm and complement these predictions...
  12. pmc Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system
    Andrew R Bassett
    Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3PT, UK
    Cell Rep 4:220-8. 2013
    ..we present a simple and highly efficient method for generating and detecting mutations of any gene in Drosophila melanogaster through the use of the CRISPR/Cas9 system (clustered regularly interspaced palindromic repeats/CRISPR-..
  13. doi Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels
    Dieter Wicher
    Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll St 8, D 07745 Jena, Germany
    Nature 452:1007-11. 2008
    ..Thereby, they provide rapid and transient as well as sensitive and prolonged odorant signalling...
  14. ncbi Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome
    Annette L Parks
    Exelixis, 170 Harbor Way, South San Francisco, California 94083 0511, USA
    Nat Genet 36:288-92. 2004
    In fruit fly research, chromosomal deletions are indispensable tools for mapping mutations, characterizing alleles and identifying interacting loci. Most widely used deletions were generated by irradiation or chemical mutagenesis...
  15. pmc Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
    Adam Siepel
    Center for Biomolecular Science and Engineering, University of California, Santa Cruz, Santa Cruz, California 95064, USA
    Genome Res 15:1034-50. 2005
    ..on the details of the calibration procedure) and substantially higher fractions of the more compact Drosophila melanogaster (37%-53%), Caenorhabditis elegans (18%-37%), and Saccharaomyces cerevisiae (47%-68%) genomes...
  16. ncbi Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
    T Lee
    Department of Biological Sciences, Stanford University, California 94305, USA
    Neuron 22:451-61. 1999
    ..As an example, we show that the short stop gene is required in mushroom body neurons for the extension and guidance of their axons...
  17. ncbi Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    A E Pasquinelli
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Nature 408:86-9. 2000
    ..elegans and Drosophila, at 48 hours after fertilization in zebrafish, and in adult stages of annelids and molluscs. The let-7 regulatory RNA may control late temporal transitions during development across animal phylogeny...
  18. pmc Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    Yasemin Sancak
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 141:290-303. 2010
    ..Thus, Rag-Ragulator-mediated translocation of mTORC1 to lysosomal membranes is the key event in amino acid signaling to mTORC1...
  19. pmc Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation
    Daniel A Gilchrist
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell 143:540-51. 2010
    ....
  20. ncbi Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    Ira E Clark
    Nature 441:1162-6. 2006
    ..The role of the pink1-parkin pathway in regulating mitochondrial function underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis...
  21. ncbi Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    Birgit Czermin
    Adolf Butenandt Institut, University of Munich, Schillerstrasse 44, 80336 Munich, Germany
    Cell 111:185-96. 2002
    ..Histone H3 methylated in vitro by the E(Z)/ESC complex binds specifically to Polycomb protein...
  22. pmc RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
    Julia Zeitlinger
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1512-6. 2007
    ..We propose that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development...
  23. ncbi Histone H4-K16 acetylation controls chromatin structure and protein interactions
    Michael Shogren-Knaak
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 311:844-7. 2006
    ....
  24. ncbi Hsp90 as a capacitor for morphological evolution
    S L Rutherford
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Nature 396:336-42. 1998
    ..This provides a plausible mechanism for promoting evolutionary change in otherwise entrenched developmental processes...
  25. ncbi Correlates of sleep and waking in Drosophila melanogaster
    P J Shaw
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Science 287:1834-7. 2000
    ..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep...
  26. pmc Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
    Elena Ziviani
    Department of Biomedical Sciences, Medical Research Council Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 107:5018-23. 2010
    ..We hypothesize that Mfn ubiquitination may provide a mechanism by which terminally damaged mitochondria are labeled and sequestered for degradation by autophagy...
  27. ncbi Adaptive protein evolution at the Adh locus in Drosophila
    J H McDonald
    Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544
    Nature 351:652-4. 1991
    ..DNA sequence data on the Adh locus (encoding alcohol dehydrogenase, EC 1.1.1.1) in three species in the Drosophila melanogaster species subgroup do not fit this expectation; instead, there are more fixed replacement differences ..
  28. pmc The hippo signaling pathway in development and cancer
    Duojia Pan
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 19:491-505. 2010
    ..These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology...
  29. pmc Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary
    Colin D Malone
    Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA
    Cell 137:522-35. 2009
    ....
  30. pmc X chromosome dosage compensation via enhanced transcriptional elongation in Drosophila
    Erica Larschan
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 471:115-8. 2011
    ..Improving transcriptional output downstream of typical gene-specific controls may explain how dosage compensation can be imposed on the diverse set of genes along an entire chromosome...
  31. pmc mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
    Roberto Zoncu
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 334:678-83. 2011
    ..These results identify the v-ATPase as a component of the mTOR pathway and delineate a lysosome-associated machinery for amino acid sensing...
  32. pmc RNA polymerase is poised for activation across the genome
    Ginger W Muse
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Nat Genet 39:1507-11. 2007
    ..importance of polymerase stalling for transcription regulation, we carried out a genome-wide search for Drosophila melanogaster genes with Pol II stalled within the promoter-proximal region...
  33. ncbi Spatiotemporal rescue of memory dysfunction in Drosophila
    Sean E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 302:1765-8. 2003
    ..The TARGET system offers general utility in simultaneously addressing issues of when and where gene products are required...
  34. doi Combinatorial binding predicts spatio-temporal cis-regulatory activity
    Robert P Zinzen
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Nature 462:65-70. 2009
    ..This data-driven approach does not require previous knowledge of transcription factor sequence affinity, function or expression, making it widely applicable...
  35. pmc PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility
    Xinnan Wang
    F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 147:893-906. 2011
    ..PINK1 has been shown to act upstream of Parkin, but the mechanism corresponding to this relationship has not been known. We propose that PINK1 phosphorylation of substrates triggers the subsequent action of Parkin and the proteasome...
  36. pmc Hitchhiking under positive Darwinian selection
    J C Fay
    Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 155:1405-13. 2000
    ..Application of the H test to published surveys of Drosophila variation reveals an excess of high frequency variants that are likely to have been influenced by positive selection...
  37. pmc The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    Yasemin Sancak
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology MIT, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 320:1496-501. 2008
    ..The Rag proteins do not directly stimulate the kinase activity of mTORC1, but, like amino acids, promote the intracellular localization of mTOR to a compartment that also contains its activator Rheb...
  38. doi Insect olfactory receptors are heteromeric ligand-gated ion channels
    Koji Sato
    Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
    Nature 452:1002-6. 2008
    ..The ligand-gated ion channel formed by an insect OR complex seems to be the basis for a unique strategy that insects have acquired to respond to the olfactory environment...
  39. pmc Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila
    Zhongsheng Yu
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Datun Road 15, Beijing 100101, China
    Genetics 195:289-91. 2013
    ..Genes in both heterochromatin and euchromatin can be modified efficiently. Thus the Cas9/gRNA system is an attractive tool for rapid disruption of essentially any gene in Drosophila. ..
  40. ncbi P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster
    Koen J T Venken
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 314:1747-51. 2006
    We describe a transgenesis platform for Drosophila melanogaster that integrates three recently developed technologies: a conditionally amplifiable bacterial artificial chromosome (BAC), recombineering, and bacteriophage PhiC31-mediated ..
  41. pmc Highly improved gene targeting by germline-specific Cas9 expression in Drosophila
    Shu Kondo
    Invertebrate Genetics Laboratory, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Genetics 195:715-21. 2013
    ..3-23%. Our method is readily scalable to high-throughput gene targeting, thereby accelerating comprehensive functional annotation of the Drosophila genome. ..
  42. pmc RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk
    David A MacLeod
    Department of Neurology and Taub Institute, Columbia University, Black Building 1208, 650 West 168th Street, New York, NY 10032, USA
    Neuron 77:425-39. 2013
    ..Expression of wild-type VPS35, but not a familial PD-associated mutant form, rescued these defects. Taken together, these studies implicate retromer and lysosomal pathway alterations in PD risk...
  43. ncbi Wnt proteins are lipid-modified and can act as stem cell growth factors
    Karl Willert
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 423:448-52. 2003
    ..The purified Wnt3a protein induces self-renewal of haematopoietic stem cells, signifying its potential use in tissue engineering...
  44. ncbi Role of histone H2A ubiquitination in Polycomb silencing
    Hengbin Wang
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Nature 431:873-8. 2004
    ..Thus, our studies identify the H2A ubiquitin ligase, and link H2A ubiquitination to Polycomb silencing...
  45. pmc A genome-scale shRNA resource for transgenic RNAi in Drosophila
    Jian Quan Ni
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts, USA
    Nat Methods 8:405-7. 2011
    Existing transgenic RNAi resources in Drosophila melanogaster based on long double-stranded hairpin RNAs are powerful tools for functional studies, but they are ineffective in gene knockdown during oogenesis, an important model system ..
  46. ncbi Rest in Drosophila is a sleep-like state
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 25:129-38. 2000
    To facilitate the genetic study of sleep, we documented that rest behavior in Drosophila melanogaster is a sleep-like state...
  47. pmc The PINK1/Parkin pathway regulates mitochondrial morphology
    Angela C Poole
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:1638-43. 2008
    ..Our studies suggest that the PINK1/Parkin pathway promotes mitochondrial fission and that the loss of mitochondrial and tissue integrity in PINK1 and parkin mutants derives from reduced mitochondrial fission...
  48. pmc The many landscapes of recombination in Drosophila melanogaster
    Josep M Comeron
    Department of Biology, University of Iowa, Iowa City, Iowa, USA
    PLoS Genet 8:e1002905. 2012
    ..We characterized the products of 5,860 female meioses in Drosophila melanogaster by genotyping a total of 139 million informative SNPs and mapped 106,964 recombination events at a ..
  49. ncbi Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    Eric J Rulifson
    Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
    Science 296:1118-20. 2002
    In the fruit fly Drosophila, four insulin genes are coexpressed in small clusters of cells [insulin-producing cells (IPCs)] in the brain...
  50. pmc A Drosophila model for TDP-43 proteinopathy
    Yan Li
    Department of Neurology, Lurie Cancer Center, Center for Genetic Medicine, Northwestern University School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:3169-74. 2010
    ....
  51. ncbi bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    Julius Brennecke
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Cell 113:25-36. 2003
    ..bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity...
  52. pmc A microRNA imparts robustness against environmental fluctuation during development
    Xin Li
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
    Cell 137:273-82. 2009
    ..We suggest that some conserved microRNAs like miR-7 may enter into novel genetic relationships to buffer developmental programs against variation and impart robustness to diverse regulatory networks...
  53. doi The shaping of male courtship posture by lateralized gustatory inputs to male-specific interneurons
    Masayuki Koganezawa
    Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai 980 8578, Japan
    Curr Biol 20:1-8. 2010
    Unilateral wing vibration to generate "love songs" is a hallmark of male courtship posture in Drosophila melanogaster. In contrast, males of some other Drosophila species extend both wings simultaneously during courtship...
  54. pmc Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
    Jessica C Greene
    Department of Genome Sciences, University of Washington, P O Box 357730, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:4078-83. 2003
    ....
  55. pmc miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay
    Sergej Djuranovic
    Howard Hughes Medical Institute HHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 336:237-40. 2012
    ..We next used a natural translational elongation stall to show that miRNA-mediated silencing inhibits translation at an early step, potentially translation initiation...
  56. ncbi Role for a bidentate ribonuclease in the initiation step of RNA interference
    E Bernstein
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 409:363-6. 2001
    ..The enzyme has a distinctive structure, which includes a helicase domain and dual RNase III motifs. Dicer also contains a region of homology to the RDE1/QDE2/ARGONAUTE family that has been genetically linked to RNAi...
  57. pmc Elucidation of a universal size-control mechanism in Drosophila and mammals
    Jixin Dong
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 130:1120-33. 2007
    ..These results uncover a universal size-control mechanism in metazoan...
  58. pmc The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span
    Ji Wu Wang
    Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 121:4118-26. 2011
    ..Our results establish that FUS and TDP-43 function together in vivo and suggest that molecular pathways requiring the combined activities of both of these proteins may be disrupted in ALS and FTD...
  59. pmc Principles of microRNA-target recognition
    Julius Brennecke
    European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Biol 3:e85. 2005
    ....
  60. ncbi Flies without centrioles
    Renata Basto
    The Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 125:1375-86. 2006
    ..Thus, centrioles are essential for the formation of centrosomes, cilia, and flagella, but, remarkably, they are not essential for most aspects of Drosophila development...
  61. pmc TEAD mediates YAP-dependent gene induction and growth control
    Bin Zhao
    Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 22:1962-71. 2008
    ..Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP...
  62. pmc Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila species
    Robert K Bradley
    Department of Mathematics, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 8:e1000343. 2010
    ..that initiate segmentation along the anterior-posterior axis in embryos of two closely related species: Drosophila melanogaster and Drosophila yakuba...
  63. doi Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Aurelio A Teleman
    German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem J 425:13-26. 2009
    ..I discuss both the intracellular signalling network, as well as the communication between organs in the fly...
  64. pmc The Polycomb complex PRC2 and its mark in life
    Raphael Margueron
    Institut Curie, 26 Rue d Ulm, 75005 Paris, France
    Nature 469:343-9. 2011
    ..Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes...
  65. pmc Codon-substitution models for heterogeneous selection pressure at amino acid sites
    Z Yang
    Department of Biology, University College London, London NW1 2HE, United Kingdom
    Genetics 155:431-49. 2000
    ..However, we encountered difficulties in estimating the precise distribution of omega among sites from real data sets...
  66. ncbi Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
    Julius Brennecke
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA
    Cell 128:1089-103. 2007
    ..Thus, sense piRNAs, formed following cleavage of transposon mRNAs may enhance production of antisense piRNAs, complementary to active elements, by directing cleavage of transcripts from master control loci...
  67. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  68. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..Evolutionary conservation has thus been accompanied by synergy, redundancy, and functional differentiation between DILPs, and these features may themselves be of evolutionary advantage...
  69. ncbi GAL4 system in Drosophila: a fly geneticist's Swiss army knife
    Joseph B Duffy
    Department of Biology, Indiana University, 1001 E 3rd Street, Bloomington, IN 47405, USA
    Genesis 34:1-15. 2002
  70. ncbi A single p450 allele associated with insecticide resistance in Drosophila
    P J Daborn
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Science 297:2253-6. 2002
    ..Here, via microarray analysis of all P450s in Drosophila melanogaster, we show that DDT-R, a gene conferring resistance to DDT, is associated with overtranscription of a ..
  71. ncbi A direct role for dual oxidase in Drosophila gut immunity
    Eun Mi Ha
    Division of Molecular Life Science and Center for Cell Signaling Research, Ewha Woman s University, Seoul 120 750, South Korea
    Science 310:847-50. 2005
    ..Thus, oxidant-mediated antimicrobial responses are not restricted to the phagocytes, but rather are used more broadly, including in mucosal barrier epithelia...
  72. pmc Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein
    John D Laughlin
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, M S 8303, P O Box 6511, Aurora, CO 80045, USA
    Cell 133:1255-65. 2008
    ..Therefore, the pheromone-binding protein is an inactive, extracellular ligand converted by pheromone molecules into an activator of pheromone-sensitive neurons and reveals a distinct paradigm for detection of odorants...
  73. pmc Alternative epigenetic chromatin states of polycomb target genes
    Yuri B Schwartz
    Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, Piscataway, New Jersey, United States of America
    PLoS Genet 6:e1000805. 2010
    ..These results have important implications for Polycomb gene regulation, the "bivalent" chromatin state of embryonic stem cells, and gene expression in development...
  74. doi Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution
    Ann Shyn Chiang
    Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan, R O C
    Curr Biol 21:1-11. 2011
    ..Comprehensive brain wiring maps are thus needed in order to formulate hypotheses about information flow and also to guide genetic manipulations aimed at understanding how genes and circuits orchestrate complex behaviors...
  75. pmc A comprehensive map of insulator elements for the Drosophila genome
    Nicolas Negre
    Institute for Genomics and Systems Biology, Department of Human Genetics, and Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA
    PLoS Genet 6:e1000814. 2010
    ..Together, these results provide a map demarcating the boundaries of gene regulatory units and a framework for understanding insulator function during the development and evolution of Drosophila...
  76. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
    ..Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes...
  77. ncbi hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    Shian Wu
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 114:445-56. 2003
    ..A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals...
  78. ncbi The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    Jianbin Huang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Cell 122:421-34. 2005
    ..Thus, Yki is a critical target of the Wts/Lats protein kinase and a potential oncogene...
  79. pmc Novel genes derived from noncoding DNA in Drosophila melanogaster are frequently X-linked and exhibit testis-biased expression
    Mia T Levine
    Center for Population Biology, University of California Davis, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 103:9935-9. 2006
    ..We used the well annotated genome of the genetic model system Drosophila melanogaster and genome sequences of related species to carry out a whole-genome search for new D...
  80. ncbi Two chemosensory receptors together mediate carbon dioxide detection in Drosophila
    Walton D Jones
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 445:86-90. 2007
    ..in the maxillary palps of mosquitoes and in the antennae of the more genetically tractable fruitfly, Drosophila melanogaster. The molecular identity of the chemosensory CO2 receptor, however, remains unknown...
  81. pmc CBP/p300-mediated acetylation of histone H3 on lysine 56
    Chandrima Das
    Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, PO Box 6511, Aurora Colorado 80045, USA
    Nature 459:113-7. 2009
    ....
  82. pmc Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS)
    Keith A Hanson
    Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Biol Chem 285:11068-72. 2010
    ..Here, we describe a Drosophila melanogaster model of TDP-43 proteinopathy...
  83. pmc Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
    Johanna C Scheuermann
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 465:243-7. 2010
    ..Polycomb gene silencing may thus entail a dynamic balance between H2A ubiquitination by PRC1 and dRAF, and H2A deubiquitination by PR-DUB...
  84. pmc Shadow enhancers foster robustness of Drosophila gastrulation
    Michael W Perry
    Department of Integrative Biology, University of California Berkeley, CA 94720, USA
    Curr Biol 20:1562-7. 2010
    ..These results suggest that shadow enhancers represent a novel mechanism of canalization whereby complex developmental processes "bring about one definite end-result regardless of minor variations in conditions" [6]...
  85. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  86. ncbi Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    Ru Cao
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Science 298:1039-43. 2002
    ..Methylation on H3-K27 facilitates binding of Polycomb (PC), a component of the PRC1 complex, to histone H3 amino-terminal tail. Thus, these studies establish a link between histone methylation and PcG-mediated gene silencing...
  87. ncbi SOX2 functions to maintain neural progenitor identity
    Victoria Graham
    Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuron 39:749-65. 2003
    ..Taken together, these data indicate that SOXB1 signaling is both necessary and sufficient to maintain panneural properties of neural progenitor cells...
  88. pmc Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    Bin Zhao
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 21:2747-61. 2007
    ..Our observations demonstrate that YAP plays a key role in the Hippo pathway to control cell proliferation in response to cell contact...
  89. pmc Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
    Richard C Grandison
    Institute of Healthy Ageing, Department of Genetics Evolution and Environment, University College London, UK
    Nature 462:1061-4. 2009
    ..In other organisms, including mammals, it may be possible to obtain the benefits to lifespan of dietary restriction without incurring a reduction in fecundity, through a suitable balance of nutrients in the diet...
  90. pmc Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
    Fabienne C Fiesel
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
    EMBO J 29:209-21. 2010
    ..Importantly, in vivo validation in TDP-43 knockout Drosophila melanogaster confirmed the specific downregulation of HDAC6...
  91. ncbi Cost of mating in Drosophila melanogaster females is mediated by male accessory gland products
    T Chapman
    ICAPB, University of Edinburgh, UK
    Nature 373:241-4. 1995
    Female Drosophila melanogaster with environmentally or genetically elevated rates of mating die younger than controls. This cost of mating is not attributable to receipt of sperm...
  92. pmc A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
    D N Cox
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 USA
    Genes Dev 12:3715-27. 1998
    ..Decreasing C. elegans piwi expression reduces the proliferation of GSC-equivalent cells. Thus, piwi represents a novel class of genes required for GSC division in diverse organisms...
  93. pmc Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cells
    Megha Ghildiyal
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 320:1077-81. 2008
    ..in length, that correspond to transposons and heterochromatic sequences in the somatic cells of Drosophila melanogaster. We also detected endo-siRNAs complementary to messenger RNAs (mRNAs); these siRNAs disproportionately ..
  94. pmc High-throughput ethomics in large groups of Drosophila
    Kristin Branson
    California Institute of Technology, Pasadena, California, USA
    Nat Methods 6:451-7. 2009
    ..a camera-based method for automatically quantifying the individual and social behaviors of fruit flies, Drosophila melanogaster, interacting in a planar arena...
  95. pmc 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
    Brian M Zid
    California Institute of Technology, Pasadena, CA 91125, USA
    Cell 139:149-60. 2009
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
  96. pmc Stage-specific expression profiling of Drosophila spermatogenesis suggests that meiotic sex chromosome inactivation drives genomic relocation of testis-expressed genes
    Maria D Vibranovski
    Department of Ecology, The University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 5:e1000731. 2009
    ..These results suggest MSCI as a general mechanism affecting the evolution of some testis-expressed genes...
  97. pmc Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
    Jun Hee Lee
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego UCSD, La Jolla, CA 92093 0723, USA
    Science 327:1223-8. 2010
    ....
  98. pmc Polycomb preferentially targets stalled promoters of coding and noncoding transcripts
    Daniel Enderle
    Department of Biosystems Science and Engineering, ETH Zurich, CH 4058 Basel, Switzerland
    Genome Res 21:216-26. 2011
    ..Interestingly, this set includes previously unknown promoters for primary transcripts of microRNA genes, thereby expanding the scope of Polycomb control to noncoding RNAs essential for development, apoptosis, and growth...
  99. pmc Quantitative models of the mechanisms that control genome-wide patterns of transcription factor binding during early Drosophila development
    Tommy Kaplan
    Department of Molecular and Cell Biology, California Institute of Quantitative Biosciences, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 7:e1001290. 2011
    ..biophysical forces to the binding of five regulators of early embryonic anterior-posterior patterning in Drosophila melanogaster. Predictions based on DNA sequence and in vitro protein-DNA affinities alone achieve a correlation of ∼..
  100. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...

Research Grants79

  1. Amita Sehgal; Fiscal Year: 2014
    ..nature of the endogenous circadian clock was determined largely through studies done in the fruit fly, Drosophila melanogaster. These studies showed that the clock is composed of specific genes (so-called "clock genes") whose ..
  2. A Systems Biology Approach To Cardiomyopathy in the D. Melanogaster Model System
    BRIAN O'ROURKE; Fiscal Year: 2013
    ..to the study of cardiomyopathy in a model system that leverages the power of rapid genetic manipulation, Drosophila melanogaster. Long valued as a model of cardiac development, application to the study of cardiac disease is its ..
  3. Functional and Coevolutionary Analysis of Interacting Reproductive Proteins in Dr
    GEOFFREY DAVID FINDLAY; Fiscal Year: 2013
    ..This proposal seeks to investigate these issues in the genetically tractable Drosophila melanogaster (fruit fly) model system, which bears important parallels to human and mammalian reproductive systems...
  4. Using Drosophila as a model to understand TDP-43 function in ALS
    David B Morton; Fiscal Year: 2012
    ..We are using the fruit fly, Drosophila melanogaster, as a model to understand the function of TDP- 43 in neurons and the consequences of aberrant expression...
  5. Jan Lammerding; Fiscal Year: 2016
    ..Using drosophila melanogaster models expressing a panel of lamin mutations with variable muscle involvement, we will relate effects of ..
  6. Craig Montell; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to use the fruit fly, Drosophila melanogaster, as an animal model to unravel the mechanisms through which insects respond to sensory cues, ranging from ..
  7. B Jill Venton; Fiscal Year: 2016
    ..of this research is to study the dynamics of neurotransmitter signaling in the central nervous system of Drosophila melanogaster, the fruit fly...
  8. Modeling the Evolution and Function of Drosophila cis-Regulatory Modules
    MICHAEL BRUCE EISEN; Fiscal Year: 2012
    ..of the cis-regulatory sequences that control animal development, using the embryo of the pomace fly Drosophila melanogaster as a model system...
  9. Zachary Freyberg; Fiscal Year: 2015
    ..To accomplish this, I propose to use the fly Drosophila melanogaster as a model system to identify relevant molecular targets efficiently and for eventual testing and ..
  10. William D Tracey; Fiscal Year: 2014
    ..we previously carried out a genetic screen for nociception defective mutants using the fruitfly Drosophila melanogaster. This led to our discovery of the painless gene, which shows enriched expression in nociceptive sensory ..
  11. Molecular Genetics of Caloric Restriction in Aging Flies
    Blanka Rogina; Fiscal Year: 2013
    ..Mutation in the Indy gene in the fruit fly, Drosophila melanogaster, dramatically extends life span...
  12. David W Walker; Fiscal Year: 2016
    ..The PIs'laboratories use the powerful genetics of the fruit fly Drosophila melanogaster to elucidate the mechanisms underlying metabolic regulation of stem cell behavior and lifespan...
  13. MECHANISMS OF AGING REGULATION BY DROSOPHILA GERMLINE
    Marc Tatar; Fiscal Year: 2012
    ..The identity and operation of these signals are unknown. With Drosophila melanogaster we propose to understand the function of these aging regulatory systems...
  14. Daniel E Martinez; Fiscal Year: 2014
    ..cells which produce gametes, we will investigate the possibility that, as in Caenorhabditis elegans and Drosophila melanogaster, germ cells in H. oligactis can reduce lifespan...
  15. Scott Pletcher; Fiscal Year: 2016
    ..Indeed, evidence from work in the nematode, Caenorhabditis elegans, and from our work in the fruit fly, Drosophila melanogaster, has established that aging is strongly modulated by sensory systems and that this modulation is ..
  16. Amalia Icreverzi; Fiscal Year: 2015
    ..diseased cells generally accumulate dysfunctional mitochondria;here I propose to use the model organism Drosophila melanogaster to investigate the relationship between autophagy, mitochondrial turnover, and aging...
  17. Cross regulation between JNK and Insulin Signaling
    Dirk Bohmann; Fiscal Year: 2010
    ..The applicants have found in preliminary studies on Drosophila melanogaster that stress and metabolic signaling - transduced via the Jun-N-terminal Kinase (JNK) and the IIS pathway, ..
  18. Central Nervous System Regulation of Aging Physiology in Drosophila
    Brian Y Chung; Fiscal Year: 2013
    ..brain circuits and neural signaling substrates tha control the progression of aging using the fruit fly Drosophila melanogaster as a genetically- tractable model organism...
  19. Role of bacteria in development and lifespan of Drosophila melanogaster
    William W Ja; Fiscal Year: 2012
    ..The fruit fly, Drosophila melanogaster, is a powerful system for identifying and studying the effects of genes on behavior, aging, and disease...
  20. Exploring links between circadian clocks and aging.
    Natraj Krishnan; Fiscal Year: 2012
    ..Data from our laboratory demonstrated that disruption of circadian clock in the model organism Drosophila melanogaster also leads to premature aging and compromised longevity...
  21. David W Walker; Fiscal Year: 2014
    ..molecular genetic approach to supplement the endogenous respiratory chain machinery of the fruit fly Drosophila melanogaster and hence increase respiration...
  22. SVETLANA NIKOLAEVNA RADYUK; Fiscal Year: 2016
    ..one of the clock genes leads to premature aging and impaired neuronal homeostasis in the model organism Drosophila melanogaster. We also determined that the circadian mechanism decays in peripheral clocks of aging flies due to ..
  23. Novel models for longevity research
    Christian Sell; Fiscal Year: 2012
    ..in the IGF-I receptor and signaling pathways impart lifespan extension in Caenorhabditis elegans and Drosophila melanogaster, the most robust examples of lifespan extension in mammals are associated with reductions in both IGF-I ..
  24. Molecular evolution of odorant receptor specificities in Drosophila
    STEPHANIE MARIE ROLLMANN; Fiscal Year: 2013
    ..1) to measure natural variation in olfactory behavior in a population of wild-derived inbred lines of Drosophila melanogaster;(2) to quantify the contribution of molecular variation in odorant receptors to natural variation in ..
  25. Stephen L Helfand; Fiscal Year: 2014
    ..is to understand how mutations in a single gene, Indy, result in a dramatic increase in life span in Drosophila melanogaster without a concomitant loss of reproduction, physical activity or metabolic rate...
  26. The genetics of the Drosophila IIS pathway response to changing nutrition
    ELIZABETH GRIEP KING; Fiscal Year: 2013
    ..The IIS pathway is highly conserved between Drosophila melanogaster and humans and therefore, identifying the genes controlling IIS signaling in Drosophila may directly ..
  27. Mapping and rescuing EMS-induced lethal mutations on the Drosophila X Chromosome
    Hugo J Bellen; Fiscal Year: 2010
    ..to map and deposit a collection of well defined chemically induced mutations in essential genes on the Drosophila melanogaster X chromosome for distribution by the Bloomington Drosophila Stock Center (BDSC) to the fly community...
  28. Hans G Othmer; Fiscal Year: 2016
    ..b>Drosophila melanogaster is one of several model systems for which many of the components of the signal transduction and gene ..
  29. Richard S Mann; Fiscal Year: 2016
    ..In this project, the model system to be investigated is appendage specification in the fruit fly, Drosophila melanogaster. One goal is to understand, at a molecular level, how the initial leg and wing primordia become ..
  30. Building, understanding and applying a dictionary of genetic effects
    David Houle; Fiscal Year: 2013
    ..Wing shape in Drosophila melanogaster is an excellent model system for this because the phenotype can readily be characterized in many ..
  31. Drosophila feeding behavior: New tools for the genetic dissection of prandiology
    William W Ja; Fiscal Year: 2012
    ..The fruit fly, Drosophila melanogaster, is a powerful system for studying the relationship of genes with behavior and disease...
  32. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    ..Studies supported by this grant have explored the role of sphingolipids in the model organism Drosophila melanogaster. These studies have resulted in the chemical characterization of Drosophila sphingoid bases and the ..
  33. AYLIN RACHEL RODAN; Fiscal Year: 2015
    ..D., and fellowship studies, and in particular previous experience studying Drosophila melanogaster, by developing new scientific skills in physiology and biochemistry...
  34. Novel genomic effects of Y-linked polymorphisms
    Daniel L Hartl; Fiscal Year: 2012
    ..The novelty emerges from our recent discovery that the Y chromosome of Drosophila melanogaster is polymorphic for sequences that differentially affect the expression of many hundreds of autosomal and ..
  35. Antonio V Delgado-Escueta; Fiscal Year: 2016
    ..guide which putative epilepsy genes have priority for studies of functions and disease mechanisms in Drosophila melanogaster (Aim 3), mice (Aim 2) and humans (Aim 1)...
  36. Regulation of Rhox5 Transcriptional Elongation
    Marcy E Richardson; Fiscal Year: 2013
    ..Recent studies conducted in human embryonic stem cells and Drosophila melanogaster embryos have identified transcriptional elongation as a widely used alternative control mechanism of ..
  37. Oxidative stress and neurogenetic networks in Drosophila
    Robert R H Anholt; Fiscal Year: 2010
    ..b>Drosophila melanogaster provides a genetically tractable model system, because the genetic background and environmental ..
  38. Analysis of the functions of axon guidance genes during vector mosquito developme
    MOLLY DUMAN SCHEEL; Fiscal Year: 2012
    ..recent years, evolutionary developmental biologists have applied knowledge of developmental genetics in Drosophila melanogaster, a genetically tractable model organism, to better understand development of other arthropods...
  39. Genetic Control of Axial Patterning in Drosophila Eye
    Amit Singh; Fiscal Year: 2010
    ..A well established model of the Drosophila melanogaster (fruit fly) will be employed to study dorso-ventral (DV) (axial) patterning and growth in the developing ..
  40. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
    ..Many human genetic neurodegenerative disorders are associated with defects of mitochondrial dynamics. Drosophila melanogaster spermatogenesis is an ideal model system for genetic dissection of conserved mechanisms of mitochondrial ..
  41. Is symmetrical dimethylation of Arginine 2 of Histone H3 used as an epigenetic si
    Marjorie A Oettinger; Fiscal Year: 2010
    ..Fourth, we will analyze these modifications in model organisms (S. cerevisiae, S. pombe and Drosophila melanogaster), determining both the genome-wide localization pattern of the modifications and whether they are ..
  42. Analyzing Anthrax Toxins in Drosophilia
    Ethan Bier; Fiscal Year: 2013
    ..in barrier disruption We discovered this novel effect of anthrax toxins using the model genetic system Drosophila melanogaster (fruit fly) and then validated these effects in human vascular endothelial cells as well as in vivo in ..
  43. Genome-wide Identification of Immediate Early Genes in Insects
    Anandasankar Ray; Fiscal Year: 2012
    ..few genes have been identified as IEGs in mammals, but very little is known about IEGs in insects such as Drosophila melanogaster, which is used as a model to study these biological process...
  44. GERTRUD M SCHUPBACH; Fiscal Year: 2016
    ..focuses on signaling between the female germline and its surrounding follicle cells in the ovary of Drosophila melanogaster. We have shown that the Drosophila Egfr is expressed in the follicle cells and receives a highly ..
  45. Craig Montell; Fiscal Year: 2016
    ..goal of our research is to understand the mechanisms underlying phototransduction in the fruitfly, Drosophila melanogaster. Drosophila phototransduction functions through a phospholipase C (PLC)- dependent signaling system, and ..
  46. Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunity
    MICHAEL ALLEN RIEHLE; Fiscal Year: 2012
    ..impacts on mosquito physiology and vector competence that were conceptualized for Caenorhabditis elegans, Drosophila melanogaster and mammals...
  47. Expression control in Drosophila splicing assembly factor RNP-4F
    JACK VAUGHN; Fiscal Year: 2010
    ..of the evolutionarily-conserved splicing assembly factor RNP-4F in the important genetic model organism Drosophila melanogaster. Specifically, we postulate that an isoform of dADAR adenosine deaminase plays a major role in a ..
  48. Edward A Kravitz; Fiscal Year: 2015
    ..These experimental approaches are the farthest advanced in fruit flies (Drosophila melanogaster) where powerful genetic methods allow identification and manipulation of single neurons concerned with ..
  49. Genetic and Molecular Studies of Drosophila Chromatin Remodeling Factors
    John W Tamkun; Fiscal Year: 2013
    ..To address these important issues, our laboratory uses Drosophila melanogaster as a model organism to study the function of chromatin-remodeling and modifying enzymes...
  50. Genetic control of quantitative traits associated with the metabolic syndrome
    Maria De Luca; Fiscal Year: 2013
    ..These genetic pathways will be identified by integrating genetic and expression network analysis in Drosophila melanogaster. Using this information, human population-based association studies will be performed to investigate the ..
  51. Generation of Wunen/LPP3-based therapy for muscular dystrophy
    Hannele Ruohola Baker; Fiscal Year: 2010
    ..of LPP3 that reduces the level of active second messenger, S1P can suppress dystrophic phenotypes in Drosophila melanogaster. We will now study the mechanism of sphingolipid pathway and Dystrophin interactions and further, will ..
  52. Celeste A Berg; Fiscal Year: 2016
    ..This proposal uses Drosophila melanogaster egg chambers to investigate the mechanisms that control tube size and shape...
  53. Proteomics of Cell Death via 2-D Microfluidic Profiling
    DON DEVOE; Fiscal Year: 2009
    ..By using the fruit fly Drosophila melanogaster as a model system, these studies will explore pathways and identify biomarkers associated with Caspase ..
  54. RACHAEL LOUISE FRENCH; Fiscal Year: 2016
    ..and study the molecular targets of developmental ethanol using the genetically amenable model organism Drosophila melanogaster. Drosophila melanogaster, the common fruit fly, has been utilized extensively in biological research, ..
  55. Identifying novel anti-infectives by high through-put screening in whole animals
    Frederick M Ausubel; Fiscal Year: 2013
    ..in 384-well plates is followed by secondary screening in a more highly evolved model host, the fruit fly Drosophila melanogaster, increasing the likelihood of isolating drugs that will work in humans...
  56. A Drosophila Model for Genetic Studies of Metabolism
    Carl S Thummel; Fiscal Year: 2010
    ..The goal of our research is to use the fruit fly, Drosophila melanogaster, as a simple model system to define the central regulatory pathways that control metabolism and maintain ..
  57. Discovery of Vibrio cholerae factors contributing to virulence in Drosophila.
    ALEXANDRA ELIZABETH PURDY; Fiscal Year: 2010
    ..Previous work in the Watnick laboratory has established Drosophila melanogaster as a model organism for V. cholerae intestinal infection...
  58. Alan M Lambowitz; Fiscal Year: 2016
    ..group II intron-based gene targeting methods for eukaryotic model organisms, focusing initially on Drosophila melanogaster. (4) To use Xenopus tropicalis to further develop methods for using group II introns for gene targeting ..
  59. Octopamine Neuroanatomy and Functioning in Fruit Fly Social Behavior
    KYLE LYNN GOBROGGE; Fiscal Year: 2013
    ..The fruit fly (Drosophila melanogaster) genome is fully sequenced, and as a model system, fruit flies offer numerous possibilities for ..
  60. Aging specific gene expression in Drosophila
    JOHN GERARD TOWER; Fiscal Year: 2013
    ..of this research is to understand the regulation of gene expression during aging using the model organism Drosophila melanogaster. Aging in both flies and humans is found to be associated with a tissue-specific induction of oxidative ..
  61. Alexey Veraksa; Fiscal Year: 2016
    ..SWH) pathway is a well-conserved metazoan signaling cascade that restricts organ size in the fruit fly Drosophila melanogaster and limits tumorigenesis in mammals...
  62. Developmental Regulation of the Cell Cycle in Drosophila
    LAURA ANNE LEE; Fiscal Year: 2013
    ..conservation of genes involved in the cell cycle combined with the superb genetics and cytology of Drosophila melanogaster make it an ideal model organism for studying cell-cycle regulation in a developmental context...
  63. Neal Silverman; Fiscal Year: 2016
    ..This proposal uses the fruit fly Drosophila melanogaster as a model for the study of these interactions...
  64. Edward A Kravitz; Fiscal Year: 2014
    ..Over the past decade, we have developed a Drosophila melanogaster model of aggression...
  65. A Drosophila Model for Williams Syndrome Cognitive Processing
    Ralph J Greenspan; Fiscal Year: 2010
    ..This proposal outlines a plan to develop a behavioral/genetic model in Drosophila melanogaster to study the distinctive cognitive phenotype affecting visuospatial processing found in humans with ..
  66. 2009 Neurobiology of Drosophila Conference
    David Stewart; Fiscal Year: 2009
    ..in the neurobiology research that are being made in the highly successful model system the fruit fly Drosophila melanogaster. This proposal seeks support for the 2009 conference, which is the 13th biennial international meeting in ..
  67. NEUROBIOLOGY OF DROSOPHILA CONFERENCE
    David Stewart; Fiscal Year: 2007
    ..in neurobiology research that are being made in the highly successful model system of the fruit fly Drosophila melanogaster. This proposal seeks support for the 2007 conference, which is the 12th biennial international meeting in ..
  68. GENERAL PRE-MRNA SPLICING FACTORS IN DROSOPHILA
    Donald Rio; Fiscal Year: 2001
    ..R/S) domain containing pre-mRNA splicing factor U2 snRNP auxiliary factor (U2AF) in the fruit fly, Drosophila melanogaster. This proposal capitalizes on the strengths of Drosophila as an experimental organism and allows a ..
  69. CRYOPRESERVATION OF DROSOPHILA MELANOGASTER EMBRYOS
    PETER STEPONKUS; Fiscal Year: 1993
    The ultimate goal of this project is to develop a protocol for the cryopreservtion of Drosophila melanogaster embryos. We have investigated three different strategies: conventional cryopreservation, vitrification, and supercooling...
  70. Cryopreservation of the model organism Drosophila melanogaster
    BRENT SINCLAIR; Fiscal Year: 2007
    ..to develop a viable long-term storage method to safeguard the tens of thousands of genetic variants of Drosophila melanogaster that are used in genetics, developmental biology, molecular biology and human disease research...
  71. MOLECULAR STUDIES OF FASCICLIN 2 IN NEURAL DEVELOPMENT
    Allan Harrelson; Fiscal Year: 1993
    ..and function of Fas2 by application of molecular and genetic methods primarily in the fruit fly Drosophila melanogaster, and cellular and anatomical techniques mainly in the grasshopper, Schistocerca americana...
  72. TEST OF NEUTRAL MOLECULAR EVOLUTION
    Martin Kreitman; Fiscal Year: 1999
    ..are proposed; all are based on the collection of DNA sequence data from the closely related species Drosophila melanogaster and D. simulans, as well as the species pairs D. yakuba - D. teissieri and D. erecta - D. orena...
  73. Ecdysone modulation of sexual behavior in Drosophila melanogaster
    GEOFFREY GANTER; Fiscal Year: 2009
    We will explore the control of sexual behavior of the fruit fly by the steroid hormone ecdysone. The Drosophila melanogaster model system has produced a quantity of data relevant to higher functions of the human nervous system, ..
  74. Taste and feeding circuits in Drosophila
    MICHAEL DOUGLAS GORDON; Fiscal Year: 2010
    ..proposal will examine the neural substrates of taste perception and feeding behavior in the fruit fly Drosophila melanogaster. Flies offer an excellent model system for studying this problem because they exhibit robust behavioral ..
  75. CRCNS: Automated Behavior Analysis for Model Genetic Organism
    Michael H Dickinson; Fiscal Year: 2010
    ..The effort will focus on the fruit fly, Drosophila melanogaster, because it currently represents the best opportunity for integrating state-of-the-art genetic techniques ..
  76. EFFECTS OF AGING ON GERMLINE AND SOMATIC STEM CELLS IN DROSOPHILA MELANOGASTER
    MATTHEW WALLENFANG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  77. Automated sleep detection and deprivation in the fruit fly Drosophila melanogaste
    David Johnson; Fiscal Year: 2009
    Within the last seven years, Drosophila melanogaster or common fruit fly has been shown to be an invertebrate animal model for exploring genetic and proteomic mechanisms underlying sleep...
  78. COPAS SELECT Embryo Sorter
    Deborah Andrew; Fiscal Year: 2009
    ..this application to acquire a COPAS Select Embryo Sorter for use in research and education in studies of Drosophila melanogaster and Caenorhabditis elegans...
  79. Characterization of a mutation that affects feeding and digestion in Drosophila
    EDWARD BLUMENTHAL; Fiscal Year: 2009
    ..and physiological pathways required for the regulation of digestion and feeding behavior in the fruit fly Drosophila melanogaster, an organism that has proven to be an excellent model system for studies of feeding regulation and energy ..

Patents96

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  3. NUCLEIC ACID MOLECULE AND USES THEREOF
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  4. NUCLEIC ACID MOLECULE AND USES THEREOF
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  5. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
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  6. Generation of Drosophila DSCR1-GAL4, and DSCR1-GAL4, UAS-GFP double mutants preparation method of manufacturing the transgenic mutants
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  7. EARLY DEVELOPMENTAL GENOMIC ASSAY FOR CHARACTERIZING PLURIPOTENT STEM CELL UTILITY AND SAFETY
    Patent Number: EP3008229-A2; Date:2016-04-20
  8. Engineered Cells Expressing Multiple Immunomodulators and Uses Thereof
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  9. GPCR Ligand Peptides and a Conserved Motif Theirof
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  10. Topical Gels Containing Alpha Connexin C-Terminal (ACT) Peptides
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  11. Method for screening candidate repellent compound
    Patent Number: JP2014054218-A; Date:2014-03-27
  12. Archease as rna ligase complex member
    Patent Number: JP2015515485-A; Date:2015-05-28
  13. NUCLEIC ACIDS FOR NUCLEIC ACID AMPLIFICATION
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  14. PROCESSES FOR PRODUCING LIPIDS
    Patent Number: EP2798066-A1; Date:2014-11-05
  15. TOPICAL GELS CONTAINING ALPHA CONNEXIN C-TERMINAL (ACT) PEPTIDES
    Patent Number: JP2015513549-A; Date:2015-05-14
  16. STABLE TRANSFORMATION OF A POPULATION AND A METHOD OF BIOCONTAINMENT USING HAPLOINSUFFICIENCY AND UNDERDOMINANCE PRINCIPLES
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  17. SNORNA, COMPOSITIONS AND USES
    Patent Number: WO2015067727-A1; Date:2015-05-14
  18. Method for screening candidate repellent compound
    Patent Number: JP2014117166-A; Date:2014-06-30
  19. Method for screening candidate repellent compound
    Patent Number: JP2014117167-A; Date:2014-06-30
  20. Method for screening candidate repellent compound
    Patent Number: JP2014117168-A; Date:2014-06-30
  21. Vectors Conditionally Expressing Protein
    Patent Number: JP2014512808-A; Date:2014-05-29
  22. Method for screening candidate repellent compound
    Patent Number: JP2014124120-A; Date:2014-07-07
  23. Method for screening candidate repellent compound
    Patent Number: JP2014124121-A; Date:2014-07-07
  24. PROCESSES FOR PRODUCING LIPIDS
    Patent Number: JP2015511118-A; Date:2015-04-16
  25. NUCLEIC ACIDS FOR NUCLEIC ACID AMPLIFICATION
    Patent Number: JP2015512638-A; Date:2015-04-30
  26. Chimeric retinoid X receptors and their use in a novel ecdysone receptor-based inducible gene expression system
    Patent Number: JP2015119722-A; Date:2015-07-02
  27. Protease screening methods and proteases identified thereby
    Patent Number: KR1020150033726-A; Date:2015-04-01
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    Patent Number: KR1020150115968-A; Date:2015-10-14
  29. Biocontrol
    Patent Number: JP2015516800-A; Date:2015-06-18
  30. Drug screening method for neurodegenerative disease using model Drosophila for Gaucher disease
    Patent Number: JP2015172543-A; Date:2015-10-01
  31. DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
    Patent Number: JP2014131515-A; Date:2014-07-17
  32. Method of identifying eukaryotic species
    Patent Number: JP2014155500-A; Date:2014-08-28
  33. PROTEASE SCREENING METHODS AND PROTEASES IDENTIFIED THEREBY
    Patent Number: JP2015062422-A; Date:2015-04-09
  34. VECTORS CONDITIONALLY EXPRESSING PROTEIN
    Patent Number: EP2681327-A2; Date:2014-01-08
  35. Composition and methods for modulating cns activity
    Patent Number: WO2005061002-A2; Date:2005-07-07
  36. NEURODEGENERATIVE DISORDERS
    Patent Number: WO2012007740-A1; Date:2012-01-19
  37. METHOD FOR IDENTIFYING TRANSCRIPTIONAL REGULATORY ELEMENTS
    Patent Number: WO2013186306-A1; Date:2013-12-19
  38. Screening method for compositions for controlling insects
    Patent Number: EP2533046-A1; Date:2012-12-12
  39. Methods for screening insecticides
    Patent Number: WO2005083442-A1; Date:2005-09-09
  40. Identification and use of molecules implicated in pain
    Patent Number: EP1279744-A2; Date:2003-01-29
  41. Identification of JAK/STAT pathway modulating genes by genome wide RNAi screening
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  42. Preparing RNA from a wax-embedded tissue specimen
    Patent Number: EP1748085-A1; Date:2007-01-31
  43. Plants modified with mini-chromosomes
    Patent Number: WO2007030510-A2; Date:2007-03-15
  44. Juvenile hormone esterases
    Patent Number: JP2004533809-A; Date:2004-11-11
  45. POLYNUCLEOTIDES ENCODING CELLULAR TRANSPORTERS AND METHODS OF USE THEREOF
    Patent Number: JP2005506042-A; Date:2005-03-03
  46. aging specifically impairs amnesiac-dependent memory in Drosophila
    Patent Number: WO2005053387-A; Date:2005-06-16
  47. In vitro activation of cytotoxic T cells
    Patent Number: JP2006022111-A; Date:2006-01-26
  48. Diacylglycerol Acyltransferase Nucleic Acid Sequences andAssociated Products
    Patent Number: KR1020057001412-A; Date:2005-01-26
  49. OSTEOGENIC PROTEINS IN THE TREATMENT OF METABOLIC BONE DISEASES
    Patent Number: JP2007197455-A; Date:2007-08-09
  50. Enhanced prodrug activation
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    Patent Number: WO9945126-A2; Date:1999-09-10
  52. Tankyrase2 materials and methods
    Patent Number: WO0100849-A1; Date:2001-01-04
  53. Orbit and homologues thereof
    Patent Number: WO0104295-A1; Date:2001-01-18
  54. Hedgehog fusion proteins and uses
    Patent Number: WO0134654-A1; Date:2001-05-17
  55. miR-200 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
    Patent Number: JP2010504350-A; Date:2010-02-12
  56. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  57. Plants having enhanced yield-related traits and/or increased abiotic stress resistance, and a method for making the same
    Patent Number: WO2008092935-A2; Date:2008-08-07
  58. Use of a class of genes encoding lysophospholipid acyl transferases for application in agriculture, biotechnology, and medicine
    Patent Number: WO2009001315-A2; Date:2008-12-31
  59. Vectors Conditionally Expressing Therapeutic Proteins, Host Comprising the Vectors, and Uses Thereof
    Patent Number: JP2013527753-A; Date:2013-07-04
  60. A method for introduction of trehalose into animal cells by using facilitated trehalose transporter genes
    Patent Number: JP2012105677-A; Date:2012-06-07
  61. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
    Patent Number: EP2083084-A1; Date:2009-07-29
  62. Plants with increased yield and/or increased tolerance to environmental stress (iy-bm)
    Patent Number: WO2009077611-A2; Date:2009-06-25
  63. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  64. Cell-free translation system
    Patent Number: EP2216414-A1; Date:2010-08-11
  65. Plants having enhanced yield-related traits and a method for making the same
    Patent Number: WO2010007035-A1; Date:2010-01-21
  66. Screening assay for compounds targeting the p97 aaa-atpase complex in the ubiquitin proteasome system
    Patent Number: WO2010003908-A1; Date:2010-01-14
  67. Therapeutic methods and compositions based on serrate proteins and nucleic acids
    Patent Number: EP2145897-A2; Date:2010-01-20
  68. Drosophila expressing human androgen receptor
    Patent Number: JP2003102333-A; Date:2003-04-08
  69. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  70. Method for controlling insect populations
    Patent Number: EP2067787-A1; Date:2009-06-10
  71. Process for finding oligonucleotide sequences for nucleic acid amplification methods
    Patent Number: JP2001352993-A; Date:2001-12-25
  72. Methods to identify anti-tumoral agents inhibiting rasgap / aurora kinase interactions
    Patent Number: WO03087395-A2; Date:2003-10-23
  73. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  74. Lysosomal associated membrane protein (LAMP) - like polypeptide, ligands to the same, and use of the same in the frame of detection and purification of human plasmacytoid dendritic cells
    Patent Number: EP1932854-A1; Date:2008-06-18
  75. Regulation method
    Patent Number: WO03018037-A2; Date:2003-03-06
  76. Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis
    Patent Number: WO02079238-A2; Date:2002-10-10
  77. G-protein coupled receptors
    Patent Number: WO0242458-A2; Date:2002-05-30
  78. Multiple Inducible Gene Regulation System
    Patent Number: JP2013048623-A; Date:2013-03-14
  79. Nucleic acids and polypeptides of drosophila melanogaster SNF sodium-neurotransmitter symporter family cell surface receptors and methods of use
    Patent Number: EP1561818-A1; Date:2005-08-10
  80. SORGHUM CENTROMERE SEQUENCES AND MINICHROMOSOMES
    Patent Number: EP2456894-A1; Date:2012-05-30
  81. MicroRNA molecules
    Patent Number: EP2385122-A1; Date:2011-11-09
  82. MicroRNA molecules
    Patent Number: EP2428567-A1; Date:2012-03-14
  83. Nucleic acids and proteins of insect OR83B odorant receptor genes and uses thereof
    Patent Number: EP2354157-A1; Date:2011-08-10
  84. Trangenic plants wherein the transgene is a memeber of the REMORIN gene family or a consensus sequence thereof having enhanced yield-related traits and a method for making the same
    Patent Number: EP2275560-A2; Date:2011-01-19
  85. USE OF A HSPC117 MOLECULE AS RNA LIGASE
    Patent Number: WO2012028606-A1; Date:2012-03-08
  86. Expression of class 2 mannosidase and class iii mannosidase in lower eukaryotic cells
    Patent Number: WO2004074498-A2; Date:2004-09-02
  87. A new element of the wg/wnt signaling pathway
    Patent Number: WO2006097335-A1; Date:2006-09-21
  88. A novel protein and DNA encoding it
    Patent Number: WO2003089646-A; Date:2003-10-30
  89. PROTEASE SCREENING METHODS AND PROTEASES IDENTIFIED THEREBY
    Patent Number: JP2012034701-A; Date:2012-02-23
  90. A Screening Assay for insecticides
    Patent Number: JP2012507273-A; Date:2012-03-29
  91. Use of replicators to prevent gene silencing
    Patent Number: WO2007030588-A1; Date:2007-03-15
  92. Juvenile hormone acid methyltransferase gene and use thereof
    Patent Number: WO2004065604-A; Date:2004-08-05
  93. DNA ENCODING AN ARTHROPOD CHITIN SYNTHASE
    Patent Number: WO9853053-A2; Date:1998-11-26
  94. Plants having enhanced yield-related traits and a method for making the same
    Patent Number: WO2010097343-A1; Date:2010-09-02
  95. Genetically encoded bioindicators of calcium-ions
    Patent Number: WO2005014636-A1; Date:2005-02-17
  96. Novel Glucuronyltransferase and gene coding such protein
    Patent Number: JP2004033064-A; Date:2004-02-05