Genomes and Genes
Alias: Drosophila melanogaster, Drosophila melangaster, Drosophila melanogaster Meigen, 1830
Publications434 found, 100 shown here
- Comprehensive analysis of the chromatin landscape in Drosophila melanogasterPeter V Kharchenko
Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 471:480-5. 2011..Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns...
- Targeted gene expression as a means of altering cell fates and generating dominant phenotypesA H Brand
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
Development 118:401-15. 1993..We have directed expression of an activated form of the Dras2 protein, resulting in dominant eye and wing defects that can be used in screens to identify other members of the Dras2 signal transduction pathway...
- Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexD D Sarbassov
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
Science 307:1098-101. 2005..Rictor-mTOR may serve as a drug target in tumors that have lost the expression of PTEN, a tumor suppressor that opposes Akt/PKB activation...
- The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adultsB Lemaitre
Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
Cell 86:973-83. 1996..Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways...
- Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nucleaseScott J Gratz
Genetics Training Program, University of Wisconsin, Madison, Madison, WI 53706, USA
Genetics 194:1029-35. 2013..This RNA-guided Cas9 system can be rapidly programmed to generate targeted alleles for probing gene function in Drosophila. ..
- HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPSUdai Bhan Pandey
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Nature 447:859-63. 2007..Here we show that autophagy acts as a compensatory degradation system when the UPS is impaired in Drosophila melanogaster, and that histone deacetylase 6 (HDAC6), a microtubule-associated deacetylase that interacts with ..
- Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfactionMattias C Larsson
Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Neuron 43:703-14. 2004..Consistent with this cellular defect, the Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. Or83b therefore encodes an atypical odorant receptor that plays an essential general role in olfaction...
- An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrasesJohannes Bischof
Frontiers in Genetics, National Center of Competence in Research, Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Proc Natl Acad Sci U S A 104:3312-7. 2007Germ-line transformation via transposable elements is a powerful tool to study gene function in Drosophila melanogaster. However, some inherent characteristics of transposon-mediated transgenesis limit its use for transgene analysis...
- MicroRNA targets in DrosophilaAnton J Enright
Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Genome Biol 5:R1. 2003..and characterization of the first few target genes regulated by miRNAs in Caenorhabditis elegans and Drosophila melanogaster have set the stage for elucidation of a novel network of regulatory control...
- Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivoRichard Benton
Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York, USA
PLoS Biol 4:e20. 2006....
- Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAsJ Graham Ruby
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Genome Res 17:1850-64. 2007..to predict miRNAs conserved among Drosophila species and large-scale sequencing of small RNAs from Drosophila melanogaster to experimentally confirm and complement these predictions...
- Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 systemAndrew R Bassett
Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3PT, UK
Cell Rep 4:220-8. 2013..we present a simple and highly efficient method for generating and detecting mutations of any gene in Drosophila melanogaster through the use of the CRISPR/Cas9 system (clustered regularly interspaced palindromic repeats/CRISPR-..
- Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channelsDieter Wicher
Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans Knöll St 8, D 07745 Jena, Germany
Nature 452:1007-11. 2008..Thereby, they provide rapid and transient as well as sensitive and prolonged odorant signalling...
- Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genomeAnnette L Parks
Exelixis, 170 Harbor Way, South San Francisco, California 94083 0511, USA
Nat Genet 36:288-92. 2004In fruit fly research, chromosomal deletions are indispensable tools for mapping mutations, characterizing alleles and identifying interacting loci. Most widely used deletions were generated by irradiation or chemical mutagenesis...
- Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomesAdam Siepel
Center for Biomolecular Science and Engineering, University of California, Santa Cruz, Santa Cruz, California 95064, USA
Genome Res 15:1034-50. 2005..on the details of the calibration procedure) and substantially higher fractions of the more compact Drosophila melanogaster (37%-53%), Caenorhabditis elegans (18%-37%), and Saccharaomyces cerevisiae (47%-68%) genomes...
- Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesisT Lee
Department of Biological Sciences, Stanford University, California 94305, USA
Neuron 22:451-61. 1999..As an example, we show that the short stop gene is required in mushroom body neurons for the extension and guidance of their axons...
- Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNAA E Pasquinelli
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Nature 408:86-9. 2000..elegans and Drosophila, at 48 hours after fertilization in zebrafish, and in adult stages of annelids and molluscs. The let-7 regulatory RNA may control late temporal transitions during development across animal phylogeny...
- Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acidsYasemin Sancak
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 141:290-303. 2010..Thus, Rag-Ragulator-mediated translocation of mTORC1 to lysosomal membranes is the key event in amino acid signaling to mTORC1...
- Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulationDaniel A Gilchrist
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Cell 143:540-51. 2010....
- Drosophila pink1 is required for mitochondrial function and interacts genetically with parkinIra E Clark
Nature 441:1162-6. 2006..The role of the pink1-parkin pathway in regulating mitochondrial function underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis...
- Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sitesBirgit Czermin
Adolf Butenandt Institut, University of Munich, Schillerstrasse 44, 80336 Munich, Germany
Cell 111:185-96. 2002..Histone H3 methylated in vitro by the E(Z)/ESC complex binds specifically to Polycomb protein...
- RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryoJulia Zeitlinger
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Genet 39:1512-6. 2007..We propose that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development...
- Histone H4-K16 acetylation controls chromatin structure and protein interactionsMichael Shogren-Knaak
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 311:844-7. 2006....
- Hsp90 as a capacitor for morphological evolutionS L Rutherford
Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
Nature 396:336-42. 1998..This provides a plausible mechanism for promoting evolutionary change in otherwise entrenched developmental processes...
- Correlates of sleep and waking in Drosophila melanogasterP J Shaw
The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
Science 287:1834-7. 2000..These results implicate the catabolism of monoamines in the regulation of sleep and waking in the fly and suggest that Drosophila may serve as a model system for the genetic dissection of sleep...
- Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusinElena Ziviani
Department of Biomedical Sciences, Medical Research Council Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, United Kingdom
Proc Natl Acad Sci U S A 107:5018-23. 2010..We hypothesize that Mfn ubiquitination may provide a mechanism by which terminally damaged mitochondria are labeled and sequestered for degradation by autophagy...
- Adaptive protein evolution at the Adh locus in DrosophilaJ H McDonald
Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544
Nature 351:652-4. 1991..DNA sequence data on the Adh locus (encoding alcohol dehydrogenase, EC 126.96.36.199) in three species in the Drosophila melanogaster species subgroup do not fit this expectation; instead, there are more fixed replacement differences ..
- The hippo signaling pathway in development and cancerDuojia Pan
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Dev Cell 19:491-505. 2010..These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology...
- Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovaryColin D Malone
Watson School of Biological Sciences, Cold Spring Harbor, NY 11724, USA
Cell 137:522-35. 2009....
- X chromosome dosage compensation via enhanced transcriptional elongation in DrosophilaErica Larschan
Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Nature 471:115-8. 2011..Improving transcriptional output downstream of typical gene-specific controls may explain how dosage compensation can be imposed on the diverse set of genes along an entire chromosome...
- mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPaseRoberto Zoncu
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Science 334:678-83. 2011..These results identify the v-ATPase as a component of the mTOR pathway and delineate a lysosome-associated machinery for amino acid sensing...
- RNA polymerase is poised for activation across the genomeGinger W Muse
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Nat Genet 39:1507-11. 2007..importance of polymerase stalling for transcription regulation, we carried out a genome-wide search for Drosophila melanogaster genes with Pol II stalled within the promoter-proximal region...
- Spatiotemporal rescue of memory dysfunction in DrosophilaSean E McGuire
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 302:1765-8. 2003..The TARGET system offers general utility in simultaneously addressing issues of when and where gene products are required...
- Combinatorial binding predicts spatio-temporal cis-regulatory activityRobert P Zinzen
European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
Nature 462:65-70. 2009..This data-driven approach does not require previous knowledge of transcription factor sequence affinity, function or expression, making it widely applicable...
- PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motilityXinnan Wang
F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, MA 02115, USA
Cell 147:893-906. 2011..PINK1 has been shown to act upstream of Parkin, but the mechanism corresponding to this relationship has not been known. We propose that PINK1 phosphorylation of substrates triggers the subsequent action of Parkin and the proteasome...
- Hitchhiking under positive Darwinian selectionJ C Fay
Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
Genetics 155:1405-13. 2000..Application of the H test to published surveys of Drosophila variation reveals an excess of high frequency variants that are likely to have been influenced by positive selection...
- The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1Yasemin Sancak
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology MIT, Nine Cambridge Center, Cambridge, MA 02142, USA
Science 320:1496-501. 2008..The Rag proteins do not directly stimulate the kinase activity of mTORC1, but, like amino acids, promote the intracellular localization of mTOR to a compartment that also contains its activator Rheb...
- Insect olfactory receptors are heteromeric ligand-gated ion channelsKoji Sato
Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
Nature 452:1002-6. 2008..The ligand-gated ion channel formed by an insect OR complex seems to be the basis for a unique strategy that insects have acquired to respond to the olfactory environment...
- Highly efficient genome modifications mediated by CRISPR/Cas9 in DrosophilaZhongsheng Yu
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Datun Road 15, Beijing 100101, China
Genetics 195:289-91. 2013..Genes in both heterochromatin and euchromatin can be modified efficiently. Thus the Cas9/gRNA system is an attractive tool for rapid disruption of essentially any gene in Drosophila. ..
- P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogasterKoen J T Venken
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
Science 314:1747-51. 2006We describe a transgenesis platform for Drosophila melanogaster that integrates three recently developed technologies: a conditionally amplifiable bacterial artificial chromosome (BAC), recombineering, and bacteriophage PhiC31-mediated ..
- Highly improved gene targeting by germline-specific Cas9 expression in DrosophilaShu Kondo
Invertebrate Genetics Laboratory, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
Genetics 195:715-21. 2013..3-23%. Our method is readily scalable to high-throughput gene targeting, thereby accelerating comprehensive functional annotation of the Drosophila genome. ..
- RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease riskDavid A MacLeod
Department of Neurology and Taub Institute, Columbia University, Black Building 1208, 650 West 168th Street, New York, NY 10032, USA
Neuron 77:425-39. 2013..Expression of wild-type VPS35, but not a familial PD-associated mutant form, rescued these defects. Taken together, these studies implicate retromer and lysosomal pathway alterations in PD risk...
- Wnt proteins are lipid-modified and can act as stem cell growth factorsKarl Willert
Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 423:448-52. 2003..The purified Wnt3a protein induces self-renewal of haematopoietic stem cells, signifying its potential use in tissue engineering...
- Role of histone H2A ubiquitination in Polycomb silencingHengbin Wang
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
Nature 431:873-8. 2004..Thus, our studies identify the H2A ubiquitin ligase, and link H2A ubiquitination to Polycomb silencing...
- A genome-scale shRNA resource for transgenic RNAi in DrosophilaJian Quan Ni
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts, USA
Nat Methods 8:405-7. 2011Existing transgenic RNAi resources in Drosophila melanogaster based on long double-stranded hairpin RNAs are powerful tools for functional studies, but they are ineffective in gene knockdown during oogenesis, an important model system ..
- Rest in Drosophila is a sleep-like stateJ C Hendricks
Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
Neuron 25:129-38. 2000To facilitate the genetic study of sleep, we documented that rest behavior in Drosophila melanogaster is a sleep-like state...
- The PINK1/Parkin pathway regulates mitochondrial morphologyAngela C Poole
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 105:1638-43. 2008..Our studies suggest that the PINK1/Parkin pathway promotes mitochondrial fission and that the loss of mitochondrial and tissue integrity in PINK1 and parkin mutants derives from reduced mitochondrial fission...
- The many landscapes of recombination in Drosophila melanogasterJosep M Comeron
Department of Biology, University of Iowa, Iowa City, Iowa, USA
PLoS Genet 8:e1002905. 2012..We characterized the products of 5,860 female meioses in Drosophila melanogaster by genotyping a total of 139 million informative SNPs and mapped 106,964 recombination events at a ..
- Ablation of insulin-producing neurons in flies: growth and diabetic phenotypesEric J Rulifson
Department of Developmental Biology, Beckman Center B300, Stanford University, Stanford, CA 94305 5329, USA
Science 296:1118-20. 2002In the fruit fly Drosophila, four insulin genes are coexpressed in small clusters of cells [insulin-producing cells (IPCs)] in the brain...
- A Drosophila model for TDP-43 proteinopathyYan Li
Department of Neurology, Lurie Cancer Center, Center for Genetic Medicine, Northwestern University School of Medicine, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 107:3169-74. 2010....
- bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in DrosophilaJulius Brennecke
European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
Cell 113:25-36. 2003..bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity...
- A microRNA imparts robustness against environmental fluctuation during developmentXin Li
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
Cell 137:273-82. 2009..We suggest that some conserved microRNAs like miR-7 may enter into novel genetic relationships to buffer developmental programs against variation and impart robustness to diverse regulatory networks...
- The shaping of male courtship posture by lateralized gustatory inputs to male-specific interneuronsMasayuki Koganezawa
Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai 980 8578, Japan
Curr Biol 20:1-8. 2010Unilateral wing vibration to generate "love songs" is a hallmark of male courtship posture in Drosophila melanogaster. In contrast, males of some other Drosophila species extend both wings simultaneously during courtship...
- Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutantsJessica C Greene
Department of Genome Sciences, University of Washington, P O Box 357730, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 100:4078-83. 2003....
- miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decaySergej Djuranovic
Howard Hughes Medical Institute HHMI and Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 336:237-40. 2012..We next used a natural translational elongation stall to show that miRNA-mediated silencing inhibits translation at an early step, potentially translation initiation...
- Role for a bidentate ribonuclease in the initiation step of RNA interferenceE Bernstein
Cold Spring Harbor Laboratory, New York 11724, USA
Nature 409:363-6. 2001..The enzyme has a distinctive structure, which includes a helicase domain and dual RNase III motifs. Dicer also contains a region of homology to the RDE1/QDE2/ARGONAUTE family that has been genetically linked to RNAi...
- Elucidation of a universal size-control mechanism in Drosophila and mammalsJixin Dong
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 130:1120-33. 2007..These results uncover a universal size-control mechanism in metazoan...
- The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life spanJi Wu Wang
Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, New York 10032, USA
J Clin Invest 121:4118-26. 2011..Our results establish that FUS and TDP-43 function together in vivo and suggest that molecular pathways requiring the combined activities of both of these proteins may be disrupted in ALS and FTD...
- Principles of microRNA-target recognitionJulius Brennecke
European Molecular Biology Laboratory, Heidelberg, Germany
PLoS Biol 3:e85. 2005....
- Flies without centriolesRenata Basto
The Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
Cell 125:1375-86. 2006..Thus, centrioles are essential for the formation of centrosomes, cilia, and flagella, but, remarkably, they are not essential for most aspects of Drosophila development...
- TEAD mediates YAP-dependent gene induction and growth controlBin Zhao
Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA
Genes Dev 22:1962-71. 2008..Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP...
- Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila speciesRobert K Bradley
Department of Mathematics, University of California Berkeley, Berkeley, California, United States of America
PLoS Biol 8:e1000343. 2010..that initiate segmentation along the anterior-posterior axis in embryos of two closely related species: Drosophila melanogaster and Drosophila yakuba...
- Molecular mechanisms of metabolic regulation by insulin in DrosophilaAurelio A Teleman
German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Biochem J 425:13-26. 2009..I discuss both the intracellular signalling network, as well as the communication between organs in the fly...
- The Polycomb complex PRC2 and its mark in lifeRaphael Margueron
Institut Curie, 26 Rue d Ulm, 75005 Paris, France
Nature 469:343-9. 2011..Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes...
- Codon-substitution models for heterogeneous selection pressure at amino acid sitesZ Yang
Department of Biology, University College London, London NW1 2HE, United Kingdom
Genetics 155:431-49. 2000..However, we encountered difficulties in estimating the precise distribution of omega among sites from real data sets...
- Discrete small RNA-generating loci as master regulators of transposon activity in DrosophilaJulius Brennecke
Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA
Cell 128:1089-103. 2007..Thus, sense piRNAs, formed following cleavage of transposon mRNAs may enhance production of antisense piRNAs, complementary to active elements, by directing cleavage of transcripts from master control loci...
- Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regionsStewart MacArthur
Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
Genome Biol 10:R80. 2009....
- Molecular evolution and functional characterization of Drosophila insulin-like peptidesSebastian Gronke
Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
PLoS Genet 6:e1000857. 2010..Evolutionary conservation has thus been accompanied by synergy, redundancy, and functional differentiation between DILPs, and these features may themselves be of evolutionary advantage...
- GAL4 system in Drosophila: a fly geneticist's Swiss army knifeJoseph B Duffy
Department of Biology, Indiana University, 1001 E 3rd Street, Bloomington, IN 47405, USA
Genesis 34:1-15. 2002
- A single p450 allele associated with insecticide resistance in DrosophilaP J Daborn
Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
Science 297:2253-6. 2002..Here, via microarray analysis of all P450s in Drosophila melanogaster, we show that DDT-R, a gene conferring resistance to DDT, is associated with overtranscription of a ..
- A direct role for dual oxidase in Drosophila gut immunityEun Mi Ha
Division of Molecular Life Science and Center for Cell Signaling Research, Ewha Woman s University, Seoul 120 750, South Korea
Science 310:847-50. 2005..Thus, oxidant-mediated antimicrobial responses are not restricted to the phagocytes, but rather are used more broadly, including in mucosal barrier epithelia...
- Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding proteinJohn D Laughlin
Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, M S 8303, P O Box 6511, Aurora, CO 80045, USA
Cell 133:1255-65. 2008..Therefore, the pheromone-binding protein is an inactive, extracellular ligand converted by pheromone molecules into an activator of pheromone-sensitive neurons and reveals a distinct paradigm for detection of odorants...
- Alternative epigenetic chromatin states of polycomb target genesYuri B Schwartz
Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, Piscataway, New Jersey, United States of America
PLoS Genet 6:e1000805. 2010..These results have important implications for Polycomb gene regulation, the "bivalent" chromatin state of embryonic stem cells, and gene expression in development...
- Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolutionAnn Shyn Chiang
Brain Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan, R O C
Curr Biol 21:1-11. 2011..Comprehensive brain wiring maps are thus needed in order to formulate hypotheses about information flow and also to guide genetic manipulations aimed at understanding how genes and circuits orchestrate complex behaviors...
- A comprehensive map of insulator elements for the Drosophila genomeNicolas Negre
Institute for Genomics and Systems Biology, Department of Human Genetics, and Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA
PLoS Genet 6:e1000814. 2010..Together, these results provide a map demarcating the boundaries of gene regulatory units and a framework for understanding insulator function during the development and evolution of Drosophila...
- Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanismChunming Liu
Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
Cell 108:837-47. 2002..Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes...
- hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and wartsShian Wu
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 114:445-56. 2003..A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals...
- The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAPJianbin Huang
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Cell 122:421-34. 2005..Thus, Yki is a critical target of the Wts/Lats protein kinase and a potential oncogene...
- Novel genes derived from noncoding DNA in Drosophila melanogaster are frequently X-linked and exhibit testis-biased expressionMia T Levine
Center for Population Biology, University of California Davis, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 103:9935-9. 2006..We used the well annotated genome of the genetic model system Drosophila melanogaster and genome sequences of related species to carry out a whole-genome search for new D...
- Two chemosensory receptors together mediate carbon dioxide detection in DrosophilaWalton D Jones
Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nature 445:86-90. 2007..in the maxillary palps of mosquitoes and in the antennae of the more genetically tractable fruitfly, Drosophila melanogaster. The molecular identity of the chemosensory CO2 receptor, however, remains unknown...
- CBP/p300-mediated acetylation of histone H3 on lysine 56Chandrima Das
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, PO Box 6511, Aurora Colorado 80045, USA
Nature 459:113-7. 2009....
- Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS)Keith A Hanson
Department of Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
J Biol Chem 285:11068-72. 2010..Here, we describe a Drosophila melanogaster model of TDP-43 proteinopathy...
- Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUBJohanna C Scheuermann
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nature 465:243-7. 2010..Polycomb gene silencing may thus entail a dynamic balance between H2A ubiquitination by PRC1 and dRAF, and H2A deubiquitination by PR-DUB...
- Shadow enhancers foster robustness of Drosophila gastrulationMichael W Perry
Department of Integrative Biology, University of California Berkeley, CA 94720, USA
Curr Biol 20:1562-7. 2010..These results suggest that shadow enhancers represent a novel mechanism of canalization whereby complex developmental processes "bring about one definite end-result regardless of minor variations in conditions" ...
- Homeobox genes and axial patterningW McGinnis
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
Cell 68:283-302. 1992
- Role of histone H3 lysine 27 methylation in Polycomb-group silencingRu Cao
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
Science 298:1039-43. 2002..Methylation on H3-K27 facilitates binding of Polycomb (PC), a component of the PRC1 complex, to histone H3 amino-terminal tail. Thus, these studies establish a link between histone methylation and PcG-mediated gene silencing...
- SOX2 functions to maintain neural progenitor identityVictoria Graham
Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
Neuron 39:749-65. 2003..Taken together, these data indicate that SOXB1 signaling is both necessary and sufficient to maintain panneural properties of neural progenitor cells...
- Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlBin Zhao
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
Genes Dev 21:2747-61. 2007..Our observations demonstrate that YAP plays a key role in the Hippo pathway to control cell proliferation in response to cell contact...
- Amino-acid imbalance explains extension of lifespan by dietary restriction in DrosophilaRichard C Grandison
Institute of Healthy Ageing, Department of Genetics Evolution and Environment, University College London, UK
Nature 462:1061-4. 2009..In other organisms, including mammals, it may be possible to obtain the benefits to lifespan of dietary restriction without incurring a reduction in fecundity, through a suitable balance of nutrients in the diet...
- Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6Fabienne C Fiesel
Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Tubingen, Germany
EMBO J 29:209-21. 2010..Importantly, in vivo validation in TDP-43 knockout Drosophila melanogaster confirmed the specific downregulation of HDAC6...
- Cost of mating in Drosophila melanogaster females is mediated by male accessory gland productsT Chapman
ICAPB, University of Edinburgh, UK
Nature 373:241-4. 1995Female Drosophila melanogaster with environmentally or genetically elevated rates of mating die younger than controls. This cost of mating is not attributable to receipt of sperm...
- A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewalD N Cox
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 USA
Genes Dev 12:3715-27. 1998..Decreasing C. elegans piwi expression reduces the proliferation of GSC-equivalent cells. Thus, piwi represents a novel class of genes required for GSC division in diverse organisms...
- Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cellsMegha Ghildiyal
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 320:1077-81. 2008..in length, that correspond to transposons and heterochromatic sequences in the somatic cells of Drosophila melanogaster. We also detected endo-siRNAs complementary to messenger RNAs (mRNAs); these siRNAs disproportionately ..
- High-throughput ethomics in large groups of DrosophilaKristin Branson
California Institute of Technology, Pasadena, California, USA
Nat Methods 6:451-7. 2009..a camera-based method for automatically quantifying the individual and social behaviors of fruit flies, Drosophila melanogaster, interacting in a planar arena...
- 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in DrosophilaBrian M Zid
California Institute of Technology, Pasadena, CA 91125, USA
Cell 139:149-60. 2009..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
- Stage-specific expression profiling of Drosophila spermatogenesis suggests that meiotic sex chromosome inactivation drives genomic relocation of testis-expressed genesMaria D Vibranovski
Department of Ecology, The University of Chicago, Chicago, Illinois, United States of America
PLoS Genet 5:e1000731. 2009..These results suggest MSCI as a general mechanism affecting the evolution of some testis-expressed genes...
- Sestrin as a feedback inhibitor of TOR that prevents age-related pathologiesJun Hee Lee
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego UCSD, La Jolla, CA 92093 0723, USA
Science 327:1223-8. 2010....
- Polycomb preferentially targets stalled promoters of coding and noncoding transcriptsDaniel Enderle
Department of Biosystems Science and Engineering, ETH Zurich, CH 4058 Basel, Switzerland
Genome Res 21:216-26. 2011..Interestingly, this set includes previously unknown promoters for primary transcripts of microRNA genes, thereby expanding the scope of Polycomb control to noncoding RNAs essential for development, apoptosis, and growth...
- Quantitative models of the mechanisms that control genome-wide patterns of transcription factor binding during early Drosophila developmentTommy Kaplan
Department of Molecular and Cell Biology, California Institute of Quantitative Biosciences, University of California Berkeley, Berkeley, California, United States of America
PLoS Genet 7:e1001290. 2011..biophysical forces to the binding of five regulators of early embryonic anterior-posterior patterning in Drosophila melanogaster. Predictions based on DNA sequence and in vitro protein-DNA affinities alone achieve a correlation of ∼..
- Notch signaling: cell fate control and signal integration in developmentS Artavanis-Tsakonas
Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
Science 284:770-6. 1999..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
- Amita Sehgal; Fiscal Year: 2014..nature of the endogenous circadian clock was determined largely through studies done in the fruit fly, Drosophila melanogaster. These studies showed that the clock is composed of specific genes (so-called "clock genes") whose ..
- A Systems Biology Approach To Cardiomyopathy in the D. Melanogaster Model SystemBRIAN O'ROURKE; Fiscal Year: 2013..to the study of cardiomyopathy in a model system that leverages the power of rapid genetic manipulation, Drosophila melanogaster. Long valued as a model of cardiac development, application to the study of cardiac disease is its ..
- Functional and Coevolutionary Analysis of Interacting Reproductive Proteins in DrGEOFFREY DAVID FINDLAY; Fiscal Year: 2013..This proposal seeks to investigate these issues in the genetically tractable Drosophila melanogaster (fruit fly) model system, which bears important parallels to human and mammalian reproductive systems...
- Using Drosophila as a model to understand TDP-43 function in ALSDavid B Morton; Fiscal Year: 2012..We are using the fruit fly, Drosophila melanogaster, as a model to understand the function of TDP- 43 in neurons and the consequences of aberrant expression...
- Jan Lammerding; Fiscal Year: 2016..Using drosophila melanogaster models expressing a panel of lamin mutations with variable muscle involvement, we will relate effects of ..
- Craig Montell; Fiscal Year: 2015DESCRIPTION (provided by applicant): The long-term goal of the proposed research is to use the fruit fly, Drosophila melanogaster, as an animal model to unravel the mechanisms through which insects respond to sensory cues, ranging from ..
- B Jill Venton; Fiscal Year: 2016..of this research is to study the dynamics of neurotransmitter signaling in the central nervous system of Drosophila melanogaster, the fruit fly...
- Modeling the Evolution and Function of Drosophila cis-Regulatory ModulesMICHAEL BRUCE EISEN; Fiscal Year: 2012..of the cis-regulatory sequences that control animal development, using the embryo of the pomace fly Drosophila melanogaster as a model system...
- Zachary Freyberg; Fiscal Year: 2015..To accomplish this, I propose to use the fly Drosophila melanogaster as a model system to identify relevant molecular targets efficiently and for eventual testing and ..
- William D Tracey; Fiscal Year: 2014..we previously carried out a genetic screen for nociception defective mutants using the fruitfly Drosophila melanogaster. This led to our discovery of the painless gene, which shows enriched expression in nociceptive sensory ..
- Molecular Genetics of Caloric Restriction in Aging FliesBlanka Rogina; Fiscal Year: 2013..Mutation in the Indy gene in the fruit fly, Drosophila melanogaster, dramatically extends life span...
- David W Walker; Fiscal Year: 2016..The PIs'laboratories use the powerful genetics of the fruit fly Drosophila melanogaster to elucidate the mechanisms underlying metabolic regulation of stem cell behavior and lifespan...
- MECHANISMS OF AGING REGULATION BY DROSOPHILA GERMLINEMarc Tatar; Fiscal Year: 2012..The identity and operation of these signals are unknown. With Drosophila melanogaster we propose to understand the function of these aging regulatory systems...
- Daniel E Martinez; Fiscal Year: 2014..cells which produce gametes, we will investigate the possibility that, as in Caenorhabditis elegans and Drosophila melanogaster, germ cells in H. oligactis can reduce lifespan...
- Scott Pletcher; Fiscal Year: 2016..Indeed, evidence from work in the nematode, Caenorhabditis elegans, and from our work in the fruit fly, Drosophila melanogaster, has established that aging is strongly modulated by sensory systems and that this modulation is ..
- Amalia Icreverzi; Fiscal Year: 2015..diseased cells generally accumulate dysfunctional mitochondria;here I propose to use the model organism Drosophila melanogaster to investigate the relationship between autophagy, mitochondrial turnover, and aging...
- Cross regulation between JNK and Insulin SignalingDirk Bohmann; Fiscal Year: 2010..The applicants have found in preliminary studies on Drosophila melanogaster that stress and metabolic signaling - transduced via the Jun-N-terminal Kinase (JNK) and the IIS pathway, ..
- Central Nervous System Regulation of Aging Physiology in DrosophilaBrian Y Chung; Fiscal Year: 2013..brain circuits and neural signaling substrates tha control the progression of aging using the fruit fly Drosophila melanogaster as a genetically- tractable model organism...
- Role of bacteria in development and lifespan of Drosophila melanogasterWilliam W Ja; Fiscal Year: 2012..The fruit fly, Drosophila melanogaster, is a powerful system for identifying and studying the effects of genes on behavior, aging, and disease...
- Exploring links between circadian clocks and aging.Natraj Krishnan; Fiscal Year: 2012..Data from our laboratory demonstrated that disruption of circadian clock in the model organism Drosophila melanogaster also leads to premature aging and compromised longevity...
- David W Walker; Fiscal Year: 2014..molecular genetic approach to supplement the endogenous respiratory chain machinery of the fruit fly Drosophila melanogaster and hence increase respiration...
- SVETLANA NIKOLAEVNA RADYUK; Fiscal Year: 2016..one of the clock genes leads to premature aging and impaired neuronal homeostasis in the model organism Drosophila melanogaster. We also determined that the circadian mechanism decays in peripheral clocks of aging flies due to ..
- Novel models for longevity researchChristian Sell; Fiscal Year: 2012..in the IGF-I receptor and signaling pathways impart lifespan extension in Caenorhabditis elegans and Drosophila melanogaster, the most robust examples of lifespan extension in mammals are associated with reductions in both IGF-I ..
- Molecular evolution of odorant receptor specificities in DrosophilaSTEPHANIE MARIE ROLLMANN; Fiscal Year: 2013..1) to measure natural variation in olfactory behavior in a population of wild-derived inbred lines of Drosophila melanogaster;(2) to quantify the contribution of molecular variation in odorant receptors to natural variation in ..
- Stephen L Helfand; Fiscal Year: 2014..is to understand how mutations in a single gene, Indy, result in a dramatic increase in life span in Drosophila melanogaster without a concomitant loss of reproduction, physical activity or metabolic rate...
- The genetics of the Drosophila IIS pathway response to changing nutritionELIZABETH GRIEP KING; Fiscal Year: 2013..The IIS pathway is highly conserved between Drosophila melanogaster and humans and therefore, identifying the genes controlling IIS signaling in Drosophila may directly ..
- Mapping and rescuing EMS-induced lethal mutations on the Drosophila X ChromosomeHugo J Bellen; Fiscal Year: 2010..to map and deposit a collection of well defined chemically induced mutations in essential genes on the Drosophila melanogaster X chromosome for distribution by the Bloomington Drosophila Stock Center (BDSC) to the fly community...
- Hans G Othmer; Fiscal Year: 2016..b>Drosophila melanogaster is one of several model systems for which many of the components of the signal transduction and gene ..
- Richard S Mann; Fiscal Year: 2016..In this project, the model system to be investigated is appendage specification in the fruit fly, Drosophila melanogaster. One goal is to understand, at a molecular level, how the initial leg and wing primordia become ..
- Building, understanding and applying a dictionary of genetic effectsDavid Houle; Fiscal Year: 2013..Wing shape in Drosophila melanogaster is an excellent model system for this because the phenotype can readily be characterized in many ..
- Drosophila feeding behavior: New tools for the genetic dissection of prandiologyWilliam W Ja; Fiscal Year: 2012..The fruit fly, Drosophila melanogaster, is a powerful system for studying the relationship of genes with behavior and disease...
- Sphingolipid Metabolism in Drosophila DevelopmentJulie D Saba; Fiscal Year: 2013..Studies supported by this grant have explored the role of sphingolipids in the model organism Drosophila melanogaster. These studies have resulted in the chemical characterization of Drosophila sphingoid bases and the ..
- AYLIN RACHEL RODAN; Fiscal Year: 2015..D., and fellowship studies, and in particular previous experience studying Drosophila melanogaster, by developing new scientific skills in physiology and biochemistry...
- Novel genomic effects of Y-linked polymorphismsDaniel L Hartl; Fiscal Year: 2012..The novelty emerges from our recent discovery that the Y chromosome of Drosophila melanogaster is polymorphic for sequences that differentially affect the expression of many hundreds of autosomal and ..
- Antonio V Delgado-Escueta; Fiscal Year: 2016..guide which putative epilepsy genes have priority for studies of functions and disease mechanisms in Drosophila melanogaster (Aim 3), mice (Aim 2) and humans (Aim 1)...
- Regulation of Rhox5 Transcriptional ElongationMarcy E Richardson; Fiscal Year: 2013..Recent studies conducted in human embryonic stem cells and Drosophila melanogaster embryos have identified transcriptional elongation as a widely used alternative control mechanism of ..
- Oxidative stress and neurogenetic networks in DrosophilaRobert R H Anholt; Fiscal Year: 2010..b>Drosophila melanogaster provides a genetically tractable model system, because the genetic background and environmental ..
- Analysis of the functions of axon guidance genes during vector mosquito developmeMOLLY DUMAN SCHEEL; Fiscal Year: 2012..recent years, evolutionary developmental biologists have applied knowledge of developmental genetics in Drosophila melanogaster, a genetically tractable model organism, to better understand development of other arthropods...
- Genetic Control of Axial Patterning in Drosophila EyeAmit Singh; Fiscal Year: 2010..A well established model of the Drosophila melanogaster (fruit fly) will be employed to study dorso-ventral (DV) (axial) patterning and growth in the developing ..
- AAA ATPases linking mitochondria with microtubule processing in flies and yeastKaren G Hales; Fiscal Year: 2012..Many human genetic neurodegenerative disorders are associated with defects of mitochondrial dynamics. Drosophila melanogaster spermatogenesis is an ideal model system for genetic dissection of conserved mechanisms of mitochondrial ..
- Is symmetrical dimethylation of Arginine 2 of Histone H3 used as an epigenetic siMarjorie A Oettinger; Fiscal Year: 2010..Fourth, we will analyze these modifications in model organisms (S. cerevisiae, S. pombe and Drosophila melanogaster), determining both the genome-wide localization pattern of the modifications and whether they are ..
- Analyzing Anthrax Toxins in DrosophiliaEthan Bier; Fiscal Year: 2013..in barrier disruption We discovered this novel effect of anthrax toxins using the model genetic system Drosophila melanogaster (fruit fly) and then validated these effects in human vascular endothelial cells as well as in vivo in ..
- Genome-wide Identification of Immediate Early Genes in InsectsAnandasankar Ray; Fiscal Year: 2012..few genes have been identified as IEGs in mammals, but very little is known about IEGs in insects such as Drosophila melanogaster, which is used as a model to study these biological process...
- GERTRUD M SCHUPBACH; Fiscal Year: 2016..focuses on signaling between the female germline and its surrounding follicle cells in the ovary of Drosophila melanogaster. We have shown that the Drosophila Egfr is expressed in the follicle cells and receives a highly ..
- Craig Montell; Fiscal Year: 2016..goal of our research is to understand the mechanisms underlying phototransduction in the fruitfly, Drosophila melanogaster. Drosophila phototransduction functions through a phospholipase C (PLC)- dependent signaling system, and ..
- Insulin, IGF and Insulin Signaling: effects on Anopheles lifespan and immunityMICHAEL ALLEN RIEHLE; Fiscal Year: 2012..impacts on mosquito physiology and vector competence that were conceptualized for Caenorhabditis elegans, Drosophila melanogaster and mammals...
- Expression control in Drosophila splicing assembly factor RNP-4FJACK VAUGHN; Fiscal Year: 2010..of the evolutionarily-conserved splicing assembly factor RNP-4F in the important genetic model organism Drosophila melanogaster. Specifically, we postulate that an isoform of dADAR adenosine deaminase plays a major role in a ..
- Edward A Kravitz; Fiscal Year: 2015..These experimental approaches are the farthest advanced in fruit flies (Drosophila melanogaster) where powerful genetic methods allow identification and manipulation of single neurons concerned with ..
- Genetic and Molecular Studies of Drosophila Chromatin Remodeling FactorsJohn W Tamkun; Fiscal Year: 2013..To address these important issues, our laboratory uses Drosophila melanogaster as a model organism to study the function of chromatin-remodeling and modifying enzymes...
- Genetic control of quantitative traits associated with the metabolic syndromeMaria De Luca; Fiscal Year: 2013..These genetic pathways will be identified by integrating genetic and expression network analysis in Drosophila melanogaster. Using this information, human population-based association studies will be performed to investigate the ..
- Generation of Wunen/LPP3-based therapy for muscular dystrophyHannele Ruohola Baker; Fiscal Year: 2010..of LPP3 that reduces the level of active second messenger, S1P can suppress dystrophic phenotypes in Drosophila melanogaster. We will now study the mechanism of sphingolipid pathway and Dystrophin interactions and further, will ..
- Celeste A Berg; Fiscal Year: 2016..This proposal uses Drosophila melanogaster egg chambers to investigate the mechanisms that control tube size and shape...
- Proteomics of Cell Death via 2-D Microfluidic ProfilingDON DEVOE; Fiscal Year: 2009..By using the fruit fly Drosophila melanogaster as a model system, these studies will explore pathways and identify biomarkers associated with Caspase ..
- RACHAEL LOUISE FRENCH; Fiscal Year: 2016..and study the molecular targets of developmental ethanol using the genetically amenable model organism Drosophila melanogaster. Drosophila melanogaster, the common fruit fly, has been utilized extensively in biological research, ..
- Identifying novel anti-infectives by high through-put screening in whole animalsFrederick M Ausubel; Fiscal Year: 2013..in 384-well plates is followed by secondary screening in a more highly evolved model host, the fruit fly Drosophila melanogaster, increasing the likelihood of isolating drugs that will work in humans...
- A Drosophila Model for Genetic Studies of MetabolismCarl S Thummel; Fiscal Year: 2010..The goal of our research is to use the fruit fly, Drosophila melanogaster, as a simple model system to define the central regulatory pathways that control metabolism and maintain ..
- Discovery of Vibrio cholerae factors contributing to virulence in Drosophila.ALEXANDRA ELIZABETH PURDY; Fiscal Year: 2010..Previous work in the Watnick laboratory has established Drosophila melanogaster as a model organism for V. cholerae intestinal infection...
- Alan M Lambowitz; Fiscal Year: 2016..group II intron-based gene targeting methods for eukaryotic model organisms, focusing initially on Drosophila melanogaster. (4) To use Xenopus tropicalis to further develop methods for using group II introns for gene targeting ..
- Octopamine Neuroanatomy and Functioning in Fruit Fly Social BehaviorKYLE LYNN GOBROGGE; Fiscal Year: 2013..The fruit fly (Drosophila melanogaster) genome is fully sequenced, and as a model system, fruit flies offer numerous possibilities for ..
- Aging specific gene expression in DrosophilaJOHN GERARD TOWER; Fiscal Year: 2013..of this research is to understand the regulation of gene expression during aging using the model organism Drosophila melanogaster. Aging in both flies and humans is found to be associated with a tissue-specific induction of oxidative ..
- Alexey Veraksa; Fiscal Year: 2016..SWH) pathway is a well-conserved metazoan signaling cascade that restricts organ size in the fruit fly Drosophila melanogaster and limits tumorigenesis in mammals...
- Developmental Regulation of the Cell Cycle in DrosophilaLAURA ANNE LEE; Fiscal Year: 2013..conservation of genes involved in the cell cycle combined with the superb genetics and cytology of Drosophila melanogaster make it an ideal model organism for studying cell-cycle regulation in a developmental context...
- Neal Silverman; Fiscal Year: 2016..This proposal uses the fruit fly Drosophila melanogaster as a model for the study of these interactions...
- Edward A Kravitz; Fiscal Year: 2014..Over the past decade, we have developed a Drosophila melanogaster model of aggression...
- A Drosophila Model for Williams Syndrome Cognitive ProcessingRalph J Greenspan; Fiscal Year: 2010..This proposal outlines a plan to develop a behavioral/genetic model in Drosophila melanogaster to study the distinctive cognitive phenotype affecting visuospatial processing found in humans with ..
- 2009 Neurobiology of Drosophila ConferenceDavid Stewart; Fiscal Year: 2009..in the neurobiology research that are being made in the highly successful model system the fruit fly Drosophila melanogaster. This proposal seeks support for the 2009 conference, which is the 13th biennial international meeting in ..
- NEUROBIOLOGY OF DROSOPHILA CONFERENCEDavid Stewart; Fiscal Year: 2007..in neurobiology research that are being made in the highly successful model system of the fruit fly Drosophila melanogaster. This proposal seeks support for the 2007 conference, which is the 12th biennial international meeting in ..
- GENERAL PRE-MRNA SPLICING FACTORS IN DROSOPHILADonald Rio; Fiscal Year: 2001..R/S) domain containing pre-mRNA splicing factor U2 snRNP auxiliary factor (U2AF) in the fruit fly, Drosophila melanogaster. This proposal capitalizes on the strengths of Drosophila as an experimental organism and allows a ..
- CRYOPRESERVATION OF DROSOPHILA MELANOGASTER EMBRYOSPETER STEPONKUS; Fiscal Year: 1993The ultimate goal of this project is to develop a protocol for the cryopreservtion of Drosophila melanogaster embryos. We have investigated three different strategies: conventional cryopreservation, vitrification, and supercooling...
- Cryopreservation of the model organism Drosophila melanogasterBRENT SINCLAIR; Fiscal Year: 2007..to develop a viable long-term storage method to safeguard the tens of thousands of genetic variants of Drosophila melanogaster that are used in genetics, developmental biology, molecular biology and human disease research...
- MOLECULAR STUDIES OF FASCICLIN 2 IN NEURAL DEVELOPMENTAllan Harrelson; Fiscal Year: 1993..and function of Fas2 by application of molecular and genetic methods primarily in the fruit fly Drosophila melanogaster, and cellular and anatomical techniques mainly in the grasshopper, Schistocerca americana...
- TEST OF NEUTRAL MOLECULAR EVOLUTIONMartin Kreitman; Fiscal Year: 1999..are proposed; all are based on the collection of DNA sequence data from the closely related species Drosophila melanogaster and D. simulans, as well as the species pairs D. yakuba - D. teissieri and D. erecta - D. orena...
- Ecdysone modulation of sexual behavior in Drosophila melanogasterGEOFFREY GANTER; Fiscal Year: 2009We will explore the control of sexual behavior of the fruit fly by the steroid hormone ecdysone. The Drosophila melanogaster model system has produced a quantity of data relevant to higher functions of the human nervous system, ..
- Taste and feeding circuits in DrosophilaMICHAEL DOUGLAS GORDON; Fiscal Year: 2010..proposal will examine the neural substrates of taste perception and feeding behavior in the fruit fly Drosophila melanogaster. Flies offer an excellent model system for studying this problem because they exhibit robust behavioral ..
- CRCNS: Automated Behavior Analysis for Model Genetic OrganismMichael H Dickinson; Fiscal Year: 2010..The effort will focus on the fruit fly, Drosophila melanogaster, because it currently represents the best opportunity for integrating state-of-the-art genetic techniques ..
- EFFECTS OF AGING ON GERMLINE AND SOMATIC STEM CELLS IN DROSOPHILA MELANOGASTERMATTHEW WALLENFANG; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Automated sleep detection and deprivation in the fruit fly Drosophila melanogasteDavid Johnson; Fiscal Year: 2009Within the last seven years, Drosophila melanogaster or common fruit fly has been shown to be an invertebrate animal model for exploring genetic and proteomic mechanisms underlying sleep...
- COPAS SELECT Embryo SorterDeborah Andrew; Fiscal Year: 2009..this application to acquire a COPAS Select Embryo Sorter for use in research and education in studies of Drosophila melanogaster and Caenorhabditis elegans...
- Characterization of a mutation that affects feeding and digestion in DrosophilaEDWARD BLUMENTHAL; Fiscal Year: 2009..and physiological pathways required for the regulation of digestion and feeding behavior in the fruit fly Drosophila melanogaster, an organism that has proven to be an excellent model system for studies of feeding regulation and energy ..
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