European honey bee

Summary

Alias: Western honey bee, bee, honey bee, honeybee, Apis mellifera, Apis mellifica, Apis mellifera Linnaeus, 1758

Top Publications

  1. ncbi Molecular and functional characterization of an octopamine receptor from honeybee (Apis mellifera) brain
    Lore Grohmann
    Institut für Ökologie, Technische Universitat Berlin, Berlin, Germany
    J Neurochem 86:725-35. 2003
  2. pmc CYP9Q-mediated detoxification of acaricides in the honey bee (Apis mellifera)
    Wenfu Mao
    Department of Entomology, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 108:12657-62. 2011
  3. pmc Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone
    Anna Petryk
    Department of Pediatrics, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:13773-8. 2003
  4. ncbi Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L
    K Ohashi
    Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Eur J Biochem 249:797-802. 1997
  5. ncbi Differential expression of mitochondrial genes between queens and workers during caste determination in the honeybee Apis mellifera
    M Corona
    Departamento de Genetica y Fisiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo Postal 510 3, Cuernavaca Morelos 62250, Mexico
    J Exp Biol 202:929-38. 1999
  6. ncbi Expression of amylase and glucose oxidase in the hypopharyngeal gland with an age-dependent role change of the worker honeybee (Apis mellifera L.)
    K Ohashi
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Eur J Biochem 265:127-33. 1999
  7. ncbi Honey bee (Apis mellifera) transferrin-gene structure and the role of ecdysteroids in the developmental regulation of its expression
    Adriana Mendes do Nascimento
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Avenida Bandeirantes 3 900, Ribeirao Preto, 14040 901 SP, Brazil
    Insect Biochem Mol Biol 34:415-24. 2004
  8. pmc Sex determination in honeybees: two separate mechanisms induce and maintain the female pathway
    Tanja Gempe
    Department of Genetics, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    PLoS Biol 7:e1000222. 2009
  9. ncbi Characterization of recombinant and native Ih-channels from Apis mellifera
    Gunter Gisselmann
    Fakultat fur Biologie, Lehrstuhl für Zellphysiologie ND4, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Insect Biochem Mol Biol 33:1123-34. 2003
  10. ncbi Identification and localization of the nicotinic acetylcholine receptor alpha3 mRNA in the brain of the honeybee, Apis mellifera
    S H Thany
    Laboratoire de Neurobiologie de l Insecte E A 3037, Toulouse France
    Insect Mol Biol 12:255-62. 2003

Research Grants

  1. The Biodemographic Determinants of Life Span
    James R Carey; Fiscal Year: 2010
  2. Genomic Analyses of Intraspecific Patterns of Extreme Recombination in Honey Bees
    Olav Rueppell; Fiscal Year: 2012
  3. D1-like dopamine receptors in learning and behavior
    JULIE MUSTARD; Fiscal Year: 2005
  4. Pheromone regulation of gene expression in the brain
    Gene Robinson; Fiscal Year: 2007
  5. JACOBUS DE ROODE; Fiscal Year: 2016
  6. A General Stochastic Epigenetic Model for Evolution, Development, and Disease
    Andrew P Feinberg; Fiscal Year: 2011
  7. DEVELOPMENT AND CHARACTERIZATION OF AFRICANIZED HONEY BE
    DOUGLAS STAFFORD; Fiscal Year: 1993
  8. BEHAVIORAL AND PHYSIOLOGICAL MECHANISMS OF OLFACTION
    Brian Smith; Fiscal Year: 2009
  9. Ecological and Evolutionary Functional Genomics
    Scott Edwards; Fiscal Year: 2009
  10. Genetic Manipulation of Insects
    DAVID O BROCHTA; Fiscal Year: 2004

Patents

  1. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
  2. GABA channel subunits of pollinator insects and their uses thereof
  3. COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS
  4. Sodium channel subunits of pollinator insects and uses thereof
  5. STRAIN OF DEFORMED WING VIRUS (DWV)
  6. Polypeptide for improving crystallization
  7. HIGH THROUGHPUT SCREEN FOR BIOLOGICALLY ACTIVE POLYPEPTIDES
  8. Chimeric retinoid X receptors and their use in a novel ecdysone receptor-based inducible gene expression system
  9. Method of identifying eukaryotic species
  10. SILK PROTEINS

Detail Information

Publications250 found, 100 shown here

  1. ncbi Molecular and functional characterization of an octopamine receptor from honeybee (Apis mellifera) brain
    Lore Grohmann
    Institut für Ökologie, Technische Universitat Berlin, Berlin, Germany
    J Neurochem 86:725-35. 2003
    ..Here we report the cloning and functional characterization of the first octopamine receptor from the honeybee, Apis mellifera. The gene was isolated from a brain-specific cDNA library...
  2. pmc CYP9Q-mediated detoxification of acaricides in the honey bee (Apis mellifera)
    Wenfu Mao
    Department of Entomology, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 108:12657-62. 2011
    Although Apis mellifera, the western honey bee, has long encountered pesticides when foraging in agricultural fields, for two decades it has encountered pesticides in-hive in the form of acaricides to control Varroa destructor, a ..
  3. pmc Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone
    Anna Petryk
    Department of Pediatrics, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:13773-8. 2003
    ....
  4. ncbi Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L
    K Ohashi
    Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Eur J Biochem 249:797-802. 1997
    Major proteins synthesized in the hypopharyngeal gland of the worker honeybee change from bee-milk proteins to alpha-glucosidase in accordance with the age-dependent role change of the worker bee...
  5. ncbi Differential expression of mitochondrial genes between queens and workers during caste determination in the honeybee Apis mellifera
    M Corona
    Departamento de Genetica y Fisiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Apdo Postal 510 3, Cuernavaca Morelos 62250, Mexico
    J Exp Biol 202:929-38. 1999
    The nourishment received by female honeybee larvae determines their differentiation into queens or workers...
  6. ncbi Expression of amylase and glucose oxidase in the hypopharyngeal gland with an age-dependent role change of the worker honeybee (Apis mellifera L.)
    K Ohashi
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Eur J Biochem 265:127-33. 1999
    ..We have isolated cDNA clones for two honeybee (Apis mellifera L...
  7. ncbi Honey bee (Apis mellifera) transferrin-gene structure and the role of ecdysteroids in the developmental regulation of its expression
    Adriana Mendes do Nascimento
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Avenida Bandeirantes 3 900, Ribeirao Preto, 14040 901 SP, Brazil
    Insect Biochem Mol Biol 34:415-24. 2004
    ..In this study, we isolated cDNA and genomic clones encoding an Apis mellifera transferrin (AmTRF) gene. It has an open reading frame (ORF) of 2136 bp spread over nine exons...
  8. pmc Sex determination in honeybees: two separate mechanisms induce and maintain the female pathway
    Tanja Gempe
    Department of Genetics, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    PLoS Biol 7:e1000222. 2009
    Organisms have evolved a bewildering diversity of mechanisms to generate the two sexes. The honeybee (Apis mellifera) employs an interesting system in which sex is determined by heterozygosity at a single locus (the Sex Determination ..
  9. ncbi Characterization of recombinant and native Ih-channels from Apis mellifera
    Gunter Gisselmann
    Fakultat fur Biologie, Lehrstuhl für Zellphysiologie ND4, Ruhr Universitat Bochum, Universitatsstr 150, 44780 Bochum, Germany
    Insect Biochem Mol Biol 33:1123-34. 2003
    ..We isolated a cDNA (AMIH) encoding a putative member of these ion channels from Apis mellifera heads by means of polymerase chain reaction and homology screening...
  10. ncbi Identification and localization of the nicotinic acetylcholine receptor alpha3 mRNA in the brain of the honeybee, Apis mellifera
    S H Thany
    Laboratoire de Neurobiologie de l Insecte E A 3037, Toulouse France
    Insect Mol Biol 12:255-62. 2003
    ..In the honeybee Apis mellifera, pharmacological and electrophysiological studies have shown that different nicotinic acetylcholine receptor ..
  11. doi RNAi-mediated silencing of vitellogenin gene function turns honeybee (Apis mellifera) workers into extremely precocious foragers
    David Santos Marco Antonio
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Naturwissenschaften 95:953-61. 2008
    ..switch from within-hive activities to foraging behavior is a major transition in the life cycle of a honeybee (Apis mellifera) worker...
  12. doi Diversity in insect axis formation: two orthodenticle genes and hunchback act in anterior patterning and influence dorsoventral organization in the honeybee (Apis mellifera)
    Megan J Wilson
    Laboratory for Evolution and Development, National Research Centre for Growth and Development and Genetics Otago, Biochemistry Department, University of Otago, Dunedin 9054, New Zealand
    Development 138:3497-507. 2011
    ..orthodenticle genes, otd1 and otd2, and hunchback act as maternal anterior patterning genes in the honeybee (Apis mellifera) but, unlike other insects, act to pattern the majority of the anteroposterior axis...
  13. ncbi cGMP-dependent changes in phototaxis: a possible role for the foraging gene in honey bee division of labor
    Y Ben-Shahar
    Department of Entomology, University of Illinois at Urbana Champaign, 320 Morrill Hall, 505 S Goodwin Avenue, Urbana, IL 61801, USA
    J Exp Biol 206:2507-15. 2003
    Division of labor in honey bee colonies is influenced by the foraging gene (Amfor), which encodes a cGMP-dependent protein kinase (PKG)...
  14. ncbi Molecular characterization of MRJP3, highly polymorphic protein of honeybee (Apis mellifera) royal jelly
    S Albert
    Laboratory of Genetic Engineering, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Insect Biochem Mol Biol 29:427-34. 1999
    Major proteins of honey bee (Apis mellifera) royal jelly are members of the MRJP protein family. One MRJP protein termed MRJP3 exhibits a size polymorphism as detected by SDS-PAGE...
  15. ncbi Characterization of a D2-like dopamine receptor (AmDOP3) in honey bee, Apis mellifera
    Kyle T Beggs
    Department of Zoology, University of Otago, PO Box 56, Dunedin, New Zealand
    Insect Biochem Mol Biol 35:873-82. 2005
    ..in vertebrate and invertebrate nervous systems and is widely distributed in the brain of the honey bee, Apis mellifera. We report here the functional characterization and cellular localization of the putative dopamine receptor ..
  16. pmc A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee
    C Claudianos
    Research School of Biological Sciences, Australian National University, Canberra, ACT, Australia
    Insect Mol Biol 15:615-36. 2006
    The honeybee genome has substantially fewer protein coding genes ( approximately 11 000 genes) than Drosophila melanogaster ( approximately 13 500) and Anopheles gambiae ( approximately 14 000)...
  17. pmc Immunogold localization of vitellogenin in the ovaries, hypopharyngeal glands and head fat bodies of honeybee workers, Apis mellifera
    Siri Christine Seehuus
    Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, N 1432 Aas, Norway
    J Insect Sci 7:1-14. 2007
    Vitellogenin is a yolk precursor protein in most oviparous females. In the advanced eusocial honeybee, Apis mellifera (Hymenoptera: Apidae), vitellogenin has recently attracted much interest as this protein, in addition to a classical ..
  18. pmc Deep sequencing and expression of microRNAs from early honeybee (Apis mellifera) embryos reveals a role in regulating early embryonic patterning
    Lisa Zondag
    Laboratory for Evolution and Development, Genetics Otago and National Research Centre for Growth and Development, Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    BMC Evol Biol 12:211. 2012
    ..Using next-generation sequencing and in situ hybridization, we have examined the miRNA content of early honeybee embryos.
  19. ncbi Biochemical characterization, molecular cloning and localization of a putative odorant-binding protein in the honey bee Apis mellifera L. (Hymenoptera : Apidea)
    E Danty
    Neurobiologie Expérimentale et Théorie des Systèmes complexes, CNRS UPR 9081, Paris, France
    FEBS Lett 414:595-8. 1997
    A honey bee antennal water-soluble protein, APS2, was purified and characterized as the first Hymenoptera putative odorant-binding protein. Comparison of its measured Mr (13695.2+/-1...
  20. ncbi The changes of gene expression in honeybee (Apis mellifera) brains associated with ages
    Mayumi Tsuchimoto
    Department of Applied Biological Sciences School of Agricultural Sciences, Nagoya University, Japan
    Zoolog Sci 21:23-8. 2004
    Honeybee (Apis mellifera) worker bees (workers) are known to perform wide variety of tasks depending on their ages. The worker's brains also show the activity and behavior-dependent chemical and structural plasticity...
  21. ncbi Localization of alpha-glucosidases I, II, and III in organs of European honeybees, Apis mellifera L., and the origin of alpha-glucosidase in honey
    Masaki Kubota
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Biosci Biotechnol Biochem 68:2346-52. 2004
    Three kinds of alpha-glucosidases, I, II, and III, were purified from European honeybees, Apis mellifera L. In addition, an alpha-glucosidase was also purified from honey...
  22. pmc Differential gene expression between developing queens and workers in the honey bee, Apis mellifera
    J D Evans
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 96:5575-80. 1999
    ..approach for studying queen- and worker-specific gene expression in the development of the honey bee (Apis mellifera). Numerous genes appear to be differentially expressed between the two castes...
  23. ncbi Characterization of a chemosensory protein (ASP3c) from honeybee (Apis mellifera L.) as a brood pheromone carrier
    Loic Briand
    Biochimie et Structure des Protéines, Unite de recherches INRA 477, Jouy en Josas Cedex, France
    Eur J Biochem 269:4586-96. 2002
    ..We report the cloning of a honeybee CSP gene called ASP3c, as well as the structural and functional characterization of the encoded protein...
  24. ncbi Am5-HT7: molecular and pharmacological characterization of the first serotonin receptor of the honeybee (Apis mellifera)
    Jana Schlenstedt
    Institute of Biochemistry and Biology, University of Potsdam, Golm, Germany
    J Neurochem 98:1985-98. 2006
    ..We have isolated a cDNA from the honeybee Apis mellifera (Am5-ht7) sharing high similarity to members of the 5-HT(7) receptor family...
  25. pmc Function and evolution of a gene family encoding odorant binding-like proteins in a social insect, the honey bee (Apis mellifera)
    Sylvain Foret
    Visual Sciences and ARC Centre for the Molecular Genetics of Development, Research School of Biological Sciences, The Australian National University, Canberra ACT 0200, Australia
    Genome Res 16:1404-13. 2006
    ..and experimental approaches to characterize the OBP-like gene family in a highly social insect, the Western honey bee. Comparison with other insects shows that the honey bee has the smallest set of these genes, consisting of ..
  26. doi Evidence for the evolutionary nascence of a novel sex determination pathway in honeybees
    Martin Hasselmann
    Department of Genetics, Heinrich Heine University Duesseldorf, Universitaetsstrasse 1, 40225 Duesseldorf, Germany
    Nature 454:519-22. 2008
    Sex determination in honeybees (Apis mellifera) is governed by heterozygosity at a single locus harbouring the complementary sex determiner (csd) gene, in contrast to the well-studied sex chromosome system of Drosophila melanogaster...
  27. pmc Patterns of conservation and change in honey bee developmental genes
    Peter K Dearden
    Laboratory for Evolution and Development, Biochemistry Department, University of Otago, Dunedin, Aotearoa New Zealand
    Genome Res 16:1376-84. 2006
    ..paper we examine the conservation and divergence of genes and developmental processes between Drosophila and the honey bee; two holometabolous insects whose lineages separated approximately 300 million years ago, by comparing the ..
  28. ncbi Influence of gene action across different time scales on behavior
    Y Ben-Shahar
    Department of Entomology, Neuroscience Program, University of Illinois at Urbana Champaign, 320 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA
    Science 296:741-4. 2002
    ..Previous research showed that allelic differences in PKG expression result in two Drosophila foraging variants. The same gene can thus exert different types of influence on a behavior...
  29. ncbi A candidate olfactory receptor subtype highly conserved across different insect orders
    J Krieger
    Institute of Physiology 230, University of Hohenheim, Garbenstr 30, 70599 Stuttgart, Germany
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 189:519-26. 2003
    ..In addition, based on RT-PCR experiments HR2 homologues were discovered in antennal cDNA of the honey bee (Apis mellifera; Hymenoptera), the blowfly (Calliphora erythrocephala; Diptera) and the mealworm (Tenebrio molitor; Coleoptera)..
  30. pmc Signatures of selection among sex-determining alleles of the honey bee
    Martin Hasselmann
    Institut fur Zoologie, Biozentrum, Martin Luther Universitat Halle Wittenberg, Weinberg Weg 22, 06120 Halle, Germany
    Proc Natl Acad Sci U S A 101:4888-93. 2004
    ..for sex determination, the complementary sex determiner (csd), has been most recently identified in the honey bee. Females are heterozygous at this locus...
  31. ncbi Apis mellifera ultraspiracle: cDNA sequence and rapid up-regulation by juvenile hormone
    A R Barchuk
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    Insect Mol Biol 13:459-67. 2004
    ..We have cloned and sequenced a cDNA encoding Apis mellifera ultraspiracle (AMUSP) and examined its responses to JH...
  32. ncbi Gene expression of ecdysteroid-regulated gene E74 of the honeybee in ovary and brain
    R K Paul
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Insect Mol Biol 14:9-15. 2005
    To facilitate studies of hormonal control in the honeybee (Apis mellifera L.), a cDNA for a honeybee homologue of the ecdysteroid-regulated gene E74 (AmE74) was isolated and its expression was analysed...
  33. ncbi Hymenoptera venom allergens
    Donald R Hoffman
    Department of Pathology and Laboratory Medicine, Brody School of Medicine at East Carolina University, Greenville, NC, USA
    Clin Rev Allergy Immunol 30:109-28. 2006
    ..Examples of the use of these techniques with venom proteins are presented...
  34. pmc The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Physiology Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    Genome Res 16:1422-30. 2006
    ..The honey bee, Apis mellifera, is one of the most beneficial insects worldwide, playing an important role in crop pollination, and is also a ..
  35. ncbi A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera
    Frank Hauser
    Center for Functional and Comparative Insect Genomics, Department of Cell Biology and Comparative Zoology, Institute of Biology, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Prog Neurobiol 80:1-19. 2006
    ..to annotate the neurohormone GPCR genes present in the recently sequenced genome from the honey bee Apis mellifera. We found 35 neuropeptide receptor genes in the honey bee (44 in Drosophila) and two genes, coding for leucine-..
  36. doi The insulin signaling pathway in honey bee (Apis mellifera) caste development - differential expression of insulin-like peptides and insulin receptors in queen and worker larvae
    Sergio Vicente de Azevedo
    Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto, Biologia Celular e Molecular e Bioagentes Patogenicos, Avenida Bandeirantes 3900, 14049 900 Ribeirao Preto, SP Brazil
    J Insect Physiol 54:1064-71. 2008
    ..insulin-like peptides (AmILP-1 and AmILP-2) and the two insulin receptors (AmInR-1 and AmInR-2) predicted in the honey bee genome...
  37. doi Expression analysis of putative vitellogenin and lipophorin receptors in honey bee (Apis mellifera L.) queens and workers
    Karina Rosa Guidugli-Lazzarini
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, SP, Brazil
    J Insect Physiol 54:1138-47. 2008
    ..identified as putative orthologs for a vitellogenin receptor (Amvgr) and a lipophorin receptor (Amlpr) in the Apis mellifera genome...
  38. ncbi Prepro-tachykinin gene expression in the brain of the honeybee Apis mellifera
    Hideaki Takeuchi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo ku, 113 0033 Tokyo, Japan
    Cell Tissue Res 316:281-93. 2004
    ..identified a tachykinin-related peptide (AmTRP) from the mushroom bodies (MBs) of the brain of the honeybee Apis mellifera L...
  39. pmc Transcriptional profiling reveals multifunctional roles for transferrin in the honeybee, Apis mellifera
    R Kucharski
    Visual Sciences, Research School of Biological Sciences, The Australian National University, Canberra ACT 0200, Australia
    J Insect Sci 3:27. 2003
    ..have sequenced and characterized a full-length cDNA encoding a putative iron-binding transferrin (AmTRF) in the honeybee. AmTRF shows high level of sequence identity with transferrins in both vertebrates and insects (26-46%) ..
  40. pmc Reproductive protein protects functionally sterile honey bee workers from oxidative stress
    Siri Christine Seehuus
    Department of Animal and Aquacultural Sciences, Microscopy Division, Norwegian University of Life Sciences, N 1432 As, Norway
    Proc Natl Acad Sci U S A 103:962-7. 2006
    ..Here, we studied a circuit of aging in the honey bee (Apis mellifera)...
  41. pmc Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera
    Sunita Biswas
    University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
    PLoS ONE 3:e3542. 2008
    ..Here we report a genetic analysis of homologous proteins in the honey bee. As in humans, the honeybee has five large (31-246 kb, up to 12 exons each) neuroligin genes, three of which are ..
  42. doi Identification of two piwi genes and their expression profile in honeybee, Apis mellifera
    Zhen Liao
    Department of Entomology, Nanjing Agricultural University Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects, Ministry of Agriculture, Nanjing, China
    Arch Insect Biochem Physiol 74:91-102. 2010
    ..However, these genes are not well understood in most insects. To understand the function of piwi genes in honeybee reproduction, we amplified two full-length piwi-like genes, Am-aub and Am-ago3...
  43. doi Adaptive evolution of a key gene affecting queen and worker traits in the honey bee, Apis mellifera
    Clement F Kent
    Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada
    Mol Ecol 20:5226-35. 2011
    ..egg yolk precursor protein represents a well-studied case of social pleiotropy in the model organism Apis mellifera. Vitellogenin is associated with fecundity in queens and plays a major role in controlling division of labour ..
  44. ncbi Amtyr1: characterization of a gene from honeybee (Apis mellifera) brain encoding a functional tyramine receptor
    W Blenau
    Institut für Okologie und Biologie, Technische Universitat Berlin, Germany
    J Neurochem 74:900-8. 2000
    ..We have cloned a member of this gene family from the CNS of the honeybee, Apis mellifera. The deduced amino acid sequence is homologous to tyramine receptors cloned from Locusta migratoria and ..
  45. ncbi Gene expression patterns associated with queen honey bee longevity
    Miguel Corona
    Department of Entomology, University of Illinois at Urbana Champaign, 320 Morrill Hall, 505 S Goodwin Avenue, Urbana, IL 61801, USA
    Mech Ageing Dev 126:1230-8. 2005
    ..We explored these possibilities in the honey bee, a good model for the study of aging because it has a caste system in which the same genome produces both a long-..
  46. ncbi Genes encoding putative Takeout/juvenile hormone binding proteins in the honeybee (Apis mellifera) and modulation by age and juvenile hormone of the takeout-like gene GB19811
    Tzachi Hagai
    Department of Evolution, Systematics and Ecology, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Insect Biochem Mol Biol 37:689-701. 2007
    ..and characterized eight genes encoding putative Takeout/juvenile hormone binding proteins (To/JHBP) in the honeybee genome...
  47. doi Developmental characterization, function and regulation of a Laccase2 encoding gene in the honey bee, Apis mellifera (Hymenoptera, Apinae)
    Moysés Elias-Neto
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, 14040 901 Ribeirao Preto, SP, Brazil
    Insect Biochem Mol Biol 40:241-51. 2010
    ..10.3.2) may have a key role. We identified an Amlac2 gene that encodes a laccase2 in the honey bee, Apis mellifera, and investigated its function in exoskeleton differentiation...
  48. ncbi Molecular cloning of cDNA and analysis of expression of the gene for alpha-glucosidase from the hypopharyngeal gland of the honeybee Apis mellifera L
    K Ohashi
    Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Biochem Biophys Res Commun 221:380-5. 1996
    ..a molecular mass of 70 kDa from a homogenate of the hypopharyngeal gland of the older worker bee (forager bee) Apis mellifera L. (T. Kubo et al, J. Biochem., 1996, 119, 291-295)...
  49. ncbi Division of labor in the honey bee (Apis mellifera): the role of tyramine beta-hydroxylase
    Herman K Lehman
    Department of Biology, Hamilton College, Clinton, NY 13323, USA
    J Exp Biol 209:2774-84. 2006
    The biogenic amine octopamine (OA) is involved in the regulation of honey bee behavioral development; brain levels are higher in foragers than bees working in the hive, especially in the antennal lobes, and treatment causes precocious ..
  50. pmc Eph receptor and ephrin signaling in developing and adult brain of the honeybee (Apis mellifera)
    Maria Vidovic
    Visual Sciences, Research School of Biological Sciences and ARC Centre for the Molecular Genetics of Development, The Australian National University, Canberra, ACT 0200, Australia
    Dev Neurobiol 67:233-51. 2007
    ..Here, we report on the characterization of Eph receptor and ephrin orthologs in the honeybee, Apis mellifera (Am), and their role in learning and memory...
  51. ncbi Change in the expression of hypopharyngeal-gland proteins of the worker honeybees (Apis mellifera L.) with age and/or role
    T Kubo
    Faculty of Pharmaceutical Sciences, University of Tokyo
    J Biochem 119:291-5. 1996
    The roles of adult worker honeybees change with age; young workers nurse brood by secreting bee milk (royal jelly), and older workers forage for nectar and pollen and process nectar into honey...
  52. ncbi Separation, characterization and sexual heterogeneity of multiple putative odorant-binding proteins in the honeybee Apis mellifera L. (Hymenoptera: Apidea)
    E Danty
    Neurobiologie Expérimentale et Théorie des Systèmes complexes, CNRS UPR 9081, INA PG, Paris, France
    Chem Senses 23:83-91. 1998
    ..Genotype comparison of two honeybee races revealed a variability limited to this second class...
  53. ncbi Primary structure and properties of the cathepsin G/chymotrypsin inhibitor from the larval hemolymph of Apis mellifera
    J Bania
    Institute of Biochemistry and Molecular Biology, University of Wroclaw, Poland
    Eur J Biochem 262:680-7. 1999
    ..anti-cathepsin G and anti-chymotrypsin activity was purified from the larval hemolymph of the honey bee (Apis mellifera)...
  54. pmc Changes in period mRNA levels in the brain and division of labor in honey bee colonies
    D P Toma
    Departments of Ecology, Ethology, and Evolution, Entomology, and Neuroscience Program, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 97:6914-9. 2000
    ..These results extend the regulation of a "clock gene" to a social context and suggest that there are connections at the molecular level between division of labor and chronobiology in social insects...
  55. doi Molecular characterization of a novel patched-related protein in Apis mellifera and Drosophila melanogaster
    Luis Pastenes
    Laboratorio de Bioinformatica y Expresion Genica, INTA, Universidad de Chile, Macul 5540, CP 138 11, Santiago, Chile
    Arch Insect Biochem Physiol 68:156-70. 2008
    The molecular identification and characterization of the patched-related (ptr) gene and protein in Apis mellifera and Drosophila melanogaster are reported...
  56. doi Two novel proteins expressed by the venom glands of Apis mellifera and Nasonia vitripennis share an ancient C1q-like domain
    D C de Graaf
    Laboratory of Zoophysiology, Ghent University, Ghent, Belgium
    Insect Mol Biol 19:1-10. 2010
    ..study of previously unidentified two-dimensional polyacrylamide gel electrophoresis spots of honey bee (Apis mellifera, Hymenoptera) venom revealed a new protein with a C1q conserved domain (C1q-VP)...
  57. ncbi Identification and developmental profiles of hexamerins in antenna and hemolymph of the honeybee, Apis mellifera
    E Danty
    Neurobiologie Expérimentale et Théorie des Systèmes complexes, CNRS UPR 9081, Paris, France
    Insect Biochem Mol Biol 28:387-97. 1998
    ..subunits (referred to as "hexamerins" in the following text) have been identified in the developing honeybee, Apis mellifera, by N-terminal protein sequencing...
  58. ncbi Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects
    Christian Mitri
    Laboratoire de Génomique Fonctionnelle, Unité Propre de Recherche 2580 CNRS, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France
    J Biol Chem 279:9313-20. 2004
    ..Here we report the identification of a new receptor homologous to mGluRs found in Anopheles gambiae, Apis mellifera, and Drosophila melanogaster genomes and called AmXR, HBmXR, and DmXR, respectively (the mXRs group)...
  59. ncbi Octopamine receptors in the honeybee (Apis mellifera) brain and their disruption by RNA-mediated interference
    Tahira Farooqui
    Department of Entomology, The Ohio State University, 400 Aronoff Laboratory, 318 West 12th Avenue Columbus, OH 43210 1220, USA
    J Insect Physiol 50:701-13. 2004
    Octopamine plays important neuromodulatory roles in the honeybee brain. Accordingly, mRNA from a recently identified honeybee octopamine receptor (AmOA1) is distributed throughout the brain...
  60. ncbi Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera)
    P Casteels
    Plant Genetic Systems NV, Gent, Belgium
    Eur J Biochem 187:381-6. 1990
    Honeybee (Apis mellifera) are frequently exposed to and likely to be infected by plant-associated bacteria...
  61. ncbi The precursors of the bee venom constituents apamin and MCD peptide are encoded by two genes in tandem which share the same 3'-exon
    M Gmachl
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg
    J Biol Chem 270:12704-8. 1995
    ..Both cDNAs encode unusually small precursors comprising only 46 amino acids in case of apamin and 50 in the case of the MCD peptide...
  62. ncbi Functional and chemical characterization of Hymenoptaecin, an antibacterial polypeptide that is infection-inducible in the honeybee (Apis mellifera)
    P Casteels
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 268:7044-54. 1993
    ..In combination, the six-constituent "peptide antibiotics" of bee lymph provide wide-spectrum antibacterial protection in vitro by virtue of complementarity rather than synergism.
  63. ncbi Characterization of a dopamine D1 receptor from Apis mellifera: cloning, functional expression, pharmacology, and mRNA localization in the brain
    W Blenau
    Institut für Okologie und Biologie, Technische Universitat Berlin, Germany
    J Neurochem 70:15-23. 1998
    ..We have isolated a homologue of the vertebrate dopamine D1 receptor subfamily from the honeybee Apis mellifera. [3H]Lysergic acid diethylamide specifically binds to the heterologously expressed receptor with K(D) ..
  64. ncbi Arginine kinase is highly expressed in the compound eye of the honey bee, Apis mellifera
    R Kucharski
    Visual Sciences, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia
    Gene 211:343-9. 1998
    We have cloned and sequenced a 1.68-kb cDNA encoding arginine kinase in the honey bee, Apis mellifera. The predicted protein shows a high level of identity to known arginine kinases in invertebrates and to other proteins belonging to the ..
  65. ncbi A family of major royal jelly proteins of the honeybee Apis mellifera L
    J Schmitzová
    Laboratory of Genetic Engineering, Slovak Academy of Sciences, Bratislava, Slovakia
    Cell Mol Life Sci 54:1020-30. 1998
    The characterization of major proteins of honeybee larval jelly (49-87 kDa) was performed by the sequencing of new complementary DNAs (cDNAs) obtained from a honeybee head cDNA library, by the determination of N-terminal sequences of the ..
  66. ncbi In situ localization of heat-shock and histone proteins in honey-bee (Apis mellifera l.) larvae infected with Paenibacillus larvae
    A Gregorc
    Veterinary Faculty of the University of Ljubljana, Gerbiceva 60, Ljubljana, 1000, Slovenia
    Cell Biol Int 23:211-8. 1999
    ..shock proteins (Hsp70 and Hsp90) and histone protein in healthy and Paenibacillus larvae infected honeybee (Apis mellifera L.) larvae has been studied...
  67. ncbi Concentrated expression of Ca2+/ calmodulin-dependent protein kinase II and protein kinase C in the mushroom bodies of the brain of the honeybee Apis mellifera L
    A Kamikouchi
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    J Comp Neurol 417:501-10. 2000
    ..involved in the intracellular Ca2+ signal transduction is also concentrated in the mushroom bodies of the honeybee by isolating cDNA fragments that encode the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and protein ..
  68. ncbi Hox genes in the honey bee Apis mellifera
    U Walldorf
    Institut fur Genetik, Universitat Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany
    Dev Genes Evol 210:483-92. 2000
    ..Sex combs reduced (Scr), Antennapedia (Antp), and Ultrabithorax/abdominal-A (Ubx/abd-A) from the honey bee Apis mellifera. We also cloned a cDNA with the complete coding region of the Antennapedia gene from Apis...
  69. ncbi Api m 6: a new bee venom allergen
    A Kettner
    Institute of Biochemistry, University of Lausanne, Lausanne, Switzerland
    J Allergy Clin Immunol 107:914-20. 2001
    ..Characterization of the primary structure of allergens is a prerequisite for the design of new diagnostic and therapeutic tools for allergic diseases...
  70. ncbi Cloning of a catalytic subunit of cAMP-dependent protein kinase from the honeybee (Apis mellifera) and its localization in the brain
    D Eisenhardt
    Freie Universitaet Berlin, Institut für Biologie Neurobiologie, Koenigin Luise Strasse 28 30, 14195 Berlin, Germany
    Insect Mol Biol 10:173-81. 2001
    In the honeybee the cAMP-dependent signal transduction cascade has been implicated in processes underlying learning and memory. The cAMP-dependent protein kinase (PKA) is the major mediator of cAMP action...
  71. ncbi Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies
    M Shapira
    Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem, Givat Ram
    J Mol Neurosci 17:1-12. 2001
    Division of labor in honey bee colonies is highlighted by adult bees making a transition at 2-3 wk of age from working in the hive to foraging for nectar and pollen outside...
  72. ncbi Identification of a novel gene, Mblk-1, that encodes a putative transcription factor expressed preferentially in the large-type Kenyon cells of the honeybee brain
    H Takeuchi
    Bio orientated Technology Research Advancement Institution, Tokyo, Japan
    Insect Mol Biol 10:487-94. 2001
    ..To identify the genes involved in the intrinsic function of the honeybee MBs, we searched for genes preferentially expressed therein, using the differential display method...
  73. ncbi Identification of genes expressed preferentially in the honeybee mushroom bodies by combination of differential display and cDNA microarray
    Hideaki Takeuchi
    Bio Oriented Technology Research Advancement Institution BRAIN, 3 18 19, Toranomon, Minato ku, 105 0001, Tokyo, Japan
    FEBS Lett 513:230-4. 2002
    To clarify the molecular basis underlying the neural function of the honeybee mushroom bodies (MBs), we identified three genes preferentially expressed in MB using cDNA microarrays containing 480 differential display-positive candidate ..
  74. ncbi Molecular profiling of behavioural development: differential expression of mRNAs for inositol 1,4,5-trisphosphate 3-kinase isoforms in naive and experienced honeybees (Apis mellifera)
    R Kucharski
    Visual Sciences, Research School of Biological Sciences, The Australian National University, Canberra ACT 0200, Australia
    Brain Res Mol Brain Res 99:92-101. 2002
    ..DNA sequencing yielded a contig of 21.5 kb spanning the honeybee IP(3)K locus and a 3' flanking gene similar to a transcription factor NFR-kappa-B...
  75. pmc Identification and punctate nuclear localization of a novel noncoding RNA, Ks-1, from the honeybee brain
    Miyuki Sawata
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Japan
    RNA 8:772-85. 2002
    We identified a novel gene, Ks-1, which is expressed preferentially in the small-type Kenyon cells of the honeybee brain. This gene is also expressed in some of the large soma neurons in the brain and in the suboesophageal ganglion...
  76. ncbi Apisimin, a new serine-valine-rich peptide from honeybee (Apis mellifera L.) royal jelly: purification and molecular characterization
    K Bíliková
    Laboratory of Genetic Engineering, Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, SK 84238 Bratislava, Slovak Republic
    FEBS Lett 528:125-9. 2002
    A peptide named apisimin was found in honeybee (Apis mellifera L.) royal jelly (RJ)...
  77. ncbi Honeybee (Apis mellifera L.) mrjp gene family: computational analysis of putative promoters and genomic structure of mrjp1, the gene coding for the most abundant protein of larval food
    Barbora Malecova
    Institute of Chemistry, Slovak Academy of Sciences, Laboratory of Genetic Engineering, Dubravska cesta 9, 84236 Bratislava, Slovak Republic
    Gene 303:165-75. 2003
    Mrjp1 gene belongs to the honeybee mrjp gene family encoding the major royal jelly proteins (MRJPs), secreted by nurse bees into the royal jelly...
  78. ncbi The vitellogenin of the honey bee, Apis mellifera: structural analysis of the cDNA and expression studies
    M D Piulachs
    Department of Physiology and Molecular Biodiversity, Institut de Biologia Molecular de Barcelona CSIC, Jordi Girona 18, 08034 Barcelona, Spain
    Insect Biochem Mol Biol 33:459-65. 2003
    The cDNA of Apis mellifera vitellogenin was cloned and sequenced. It is 5440 bp long and contains an ORF of 1770 amino acids (including a putative signal peptide of 16 residues)...
  79. ncbi Identification of a tachykinin-related neuropeptide from the honeybee brain using direct MALDI-TOF MS and its gene expression in worker, queen and drone heads
    H Takeuchi
    Bio orientated Technology Research Advancement Institution, Toranomon, Minato ku, Tokyo, Japan
    Insect Mol Biol 12:291-8. 2003
    ..we identified and determined the amino acid sequence of a novel neuropeptide in the brain of the honeybee Apis mellifera L., termed AmTRP peptide (Apis mellifera tachykinin-related peptide), related to insect tachykinin...
  80. ncbi Identification of honeybee antennal proteins/genes expressed in a sex- and/or caste selective manner
    Azusa Kamikouchi
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Japan
    Zoolog Sci 21:53-62. 2004
    ..three candidate proteins/genes involved in caste and/or sex-specific olfactory processing in the honeybee Apis mellifera L...
  81. ncbi Characterization of the two distinct subtypes of metabotropic glutamate receptors from honeybee, Apis mellifera
    Masahiro Funada
    Department of Applied Biological Sciences, School of Agricultural Sciences, Nagoya University, Chikusa, Nagoya, 464 8601, Japan
    Neurosci Lett 359:190-4. 2004
    ..different subtypes (AmGluRA and AmGluRB) of metabotropic glutamate receptors (mGluRs) from an eusocial insect, honeybee. Both AmGluRA and AmGluRB form homodimers independently on disulfide bonds, and bind [3H]glutamate with K(D) ..
  82. ncbi Learning at different satiation levels reveals parallel functions for the cAMP-protein kinase A cascade in formation of long-term memory
    Anke Friedrich
    Institut für Biologie Neurobiologie, Freie Universitat Berlin, 14195 Berlin, Germany
    J Neurosci 24:4460-8. 2004
    ..This result provides the first evidence for a central and distinct function of the cAMP-PKA cascade connecting satiation level with learning...
  83. ncbi Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera)
    Renato Fontana
    University of Santa Cruz, Ilheus, BA, Brazil
    Peptides 25:919-28. 2004
    ..These peptides do not present any similarity with the other antimicrobial peptides from the honeybees; they are produced constitutively by the workers and secreted into Royal Jelly...
  84. pmc Identification and analysis of the minimal promoter activity of a novel noncoding nuclear RNA gene, AncR-1, from the honeybee (Apis mellifera L.)
    Miyuki Sawata
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    RNA 10:1047-58. 2004
    ..for a noncoding nuclear RNA, termed Ks-1, that is expressed preferentially in a restricted set of neurons in the honeybee brain...
  85. ncbi Two structurally different defensin genes, one of them encoding a novel defensin isoform, are expressed in honeybee Apis mellifera
    Jaroslav Klaudiny
    Laboratory of Genetic Engineering, Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 84538 Bratislava, Slovakia
    Insect Biochem Mol Biol 35:11-22. 2005
    Two defensins showing high mutual similarity have previously been characterized in honeybee Apis mellifera: royalisin, a peptide isolated from the royal jelly, and defensin, found in the hemolymph of bacterially infected bees...
  86. ncbi Developmental expression of a tyramine receptor gene in the brain of the honey bee, Apis mellifera
    Julie A Mustard
    Department of Zoology, University of Otago, 9015 Dunedin, New Zealand
    J Comp Neurol 483:66-75. 2005
    ..receptor gene, Amtyr1, is expressed in the developing brain, as well as in the brain of the adult worker honey bee. Changes in levels of Amtyr1 expression were examined using Northern analysis...
  87. pmc Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2
    Ching Wei Luo
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Proc Natl Acad Sci U S A 102:2820-5. 2005
    ..Because bursicon subunit genes are homologous to the vertebrate bone morphogenetic protein antagonists, our findings also facilitate investigation on the function of these proteins during vertebrate development...
  88. ncbi The remarkable conservation of corticotropin-releasing hormone (CRH)-binding protein in the honeybee (Apis mellifera) dates the CRH system to a common ancestor of insects and vertebrates
    Mark O Huising
    Department of Animal Physiology, Institute for Neuroscience, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Endocrinology 146:2165-70. 2005
    ..Here we report the presence of CRH-BP in the honeybee (Apis mellifera) and other insects...
  89. ncbi Molecular cloning and expression of a hexamerin cDNA from the honey bee, Apis mellifera
    Adriana D Cunha
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Av Bandeirantes 3900, Ribeirão Preto 14040 901, SP, Brazil
    J Insect Physiol 51:1135-47. 2005
    A cDNA encoding a hexamerin subunit of the Africanized honey bee (Apis mellifera) was isolated and completely sequenced. In the deduced translation product we identified the N-terminal sequence typical of the honey bee HEX 70b hexamerin...
  90. ncbi Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect
    Karina R Guidugli
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    FEBS Lett 579:4961-5. 2005
    Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks. The subsequent shift to foraging is linked to a reduced vitellogenin and an increased juvenile hormone (JH) titer...
  91. ncbi Molecular characterization of hemoglobin from the honeybee Apis mellifera
    Thomas Hankeln
    Institute of Molecular Genetics, University of Mainz, D 55099 Mainz, Germany
    J Insect Physiol 52:701-10. 2006
    ..Here we report the identification, cloning and expression analysis of a true hemoglobin gene in the honeybee Apis mellifera (Hymenoptera). The deduced amino acid sequence covers 171 residues (19...
  92. ncbi The cys-loop ligand-gated ion channel superfamily of the honeybee, Apis mellifera
    Andrew K Jones
    MRC Functional Genetics Unit, Department of Physiology Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
    Invert Neurosci 6:123-32. 2006
    ..We have described the cys-loop LGIC superfamily of the honeybee, Apis mellifera, which is an important crop pollinator and a key model for social interaction...
  93. ncbi Characterization and expression of the Hex 110 gene encoding a glutamine-rich hexamerin in the honey bee, Apis mellifera
    Marcia M G Bitondi
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    Arch Insect Biochem Physiol 63:57-72. 2006
    An N-terminal amino acid sequence of a previously reported honey bee hexamerin, HEX 110 [Danty et al...
  94. pmc Molecular and phylogenetic analyses reveal mammalian-like clockwork in the honey bee (Apis mellifera) and shed new light on the molecular evolution of the circadian clock
    Elad B Rubin
    Department of Evolution, Systematics, and Ecology, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Genome Res 16:1352-65. 2006
    The circadian clock of the honey bee is implicated in ecologically relevant complex behaviors...
  95. ncbi Influences of octopamine and juvenile hormone on locomotor behavior and period gene expression in the honeybee, Apis mellifera
    Guy Bloch
    Department of Evolution, Systematics, and Ecology, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:181-99. 2007
    ..and juvenile hormone (JH) are implicated in the regulation of age-based division of labor in the honeybee, Apis mellifera. We tested the hypothesis that these two neuroendocrine signals influence task-associated plasticity in ..
  96. ncbi RNAi-induced phenotypes suggest a novel role for a chemosensory protein CSP5 in the development of embryonic integument in the honeybee (Apis mellifera)
    J Maleszka
    ARC Centre for the Molecular Genetics of Development and Visual Sciences, Research School of Biological Sciences, The Australian National University, Canberra, ACT, 0200, Australia
    Dev Genes Evol 217:189-96. 2007
    ..of genome annotation, transcriptional profiling and RNA interference to unravel the functional significance of a honeybee gene (csp5) belonging to the CSP family...
  97. ncbi Novel cuticular proteins revealed by the honey bee genome
    R Kucharski
    ARC Centre for the Molecular Genetics of Development and Visual Sciences, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia
    Insect Biochem Mol Biol 37:128-34. 2007
    With the completion of the honey bee genome project, a transition is now occurring from the acquisition of gene sequence to understanding the role and context of gene products within the genome...
  98. ncbi Expression of two ecdysteroid-regulated genes, Broad-Complex and E75, in the brain and ovary of the honeybee (Apis mellifera L.)
    Rajib Kumar Paul
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113 0033, Japan
    Zoolog Sci 23:1085-92. 2006
    ..Mblk-1/E93 and E74, are expressed selectively in Kenyon cell subtypes in the mushroom bodies of the honeybee (Apis mellifera L.) brain...
  99. ncbi Characterization of a metabotropic glutamate receptor in the honeybee (Apis mellifera): implications for memory formation
    R Kucharski
    Visual Sciences and ARC Centre for the Molecular Genetics of Development, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia
    Invert Neurosci 7:99-108. 2007
    ..Here we characterised a member of this family in the honeybee. We show that the honeybee genome encodes a genuine mGluR (AmGluRA) that is expressed at low to medium levels in ..
  100. ncbi Manual superscaffolding of honey bee (Apis mellifera) chromosomes 12-16: implications for the draft genome assembly version 4, gene annotation, and chromosome structure
    Hugh M Robertson
    Department of Entomology, University of Illinois at Urbana Champaign, Urbana 61801, USA
    Insect Mol Biol 16:401-10. 2007
    The euchromatic arms of the five smallest telocentric chromosomes in the honey bee genome draft Assembly v4 were manually connected into superscaffolds...
  101. ncbi EcR-A expression in the brain and ovary of the honeybee (Apis mellifera L.)
    Hideaki Takeuchi
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan
    Zoolog Sci 24:596-603. 2007
    ..signaling are expressed preferentially in Kenyon-cell subtypes in the mushroom bodies of the honeybee (Apis mellifera L.)...

Research Grants44

  1. The Biodemographic Determinants of Life Span
    James R Carey; Fiscal Year: 2010
    ..and aging in honey bees and directed by Robert Page (Arizona) will address questions concerned with how the honeybee ovary is involved in post emergence development, life history development, reproduction, and life span...
  2. Genomic Analyses of Intraspecific Patterns of Extreme Recombination in Honey Bees
    Olav Rueppell; Fiscal Year: 2012
    ..exhibit the highest genomic recombination rate of all metazoans and the large offspring number of individual honeybee queens, I propose to study the patterns of recombination in the honeybee genome in detail...
  3. D1-like dopamine receptors in learning and behavior
    JULIE MUSTARD; Fiscal Year: 2005
    ..The honey bee, Apis mellifera, is particularly good for these investigations because of its ability to learn simpler as well as more complex ..
  4. Pheromone regulation of gene expression in the brain
    Gene Robinson; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): We will couple a novel model (honey bee) with powerful new genomic resources (cDNA microarray and a soon-to-be-completed complete genome sequence) to study how pheromones regulate gene expression in ..
  5. JACOBUS DE ROODE; Fiscal Year: 2016
    ..This proposal takes advantage of honeybees (Apis mellifera) and their destructive parasitic mites (Varroa destructor) to study the role of spatial structure in virulence ..
  6. A General Stochastic Epigenetic Model for Evolution, Development, and Disease
    Andrew P Feinberg; Fiscal Year: 2011
    ..plasticity in normal differentiation;(2) to study developmental epigenetics in a model organism, the honey bee Apis mellifera, in particular the idea that genetic variants with developmental differences (such as high and low pollen ..
  7. DEVELOPMENT AND CHARACTERIZATION OF AFRICANIZED HONEY BE
    DOUGLAS STAFFORD; Fiscal Year: 1993
    The northward migration from Brazil of the Africanized honey bee (AHB), Apis mellifera scutellata, following their accidental release presents a new U.S. public health concern...
  8. BEHAVIORAL AND PHYSIOLOGICAL MECHANISMS OF OLFACTION
    Brian Smith; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): This proposal will focus on using the honeybee (Apis mellifera) as a model animal species for understanding mechanisms of behavioral plasticity toward odors...
  9. Ecological and Evolutionary Functional Genomics
    Scott Edwards; Fiscal Year: 2009
    ..We have already secured the commitment of Professor Gene Robinson (University of Illinois), the leader of the honeybee genome project, as a keynote, plenary speaker...
  10. Genetic Manipulation of Insects
    DAVID O BROCHTA; Fiscal Year: 2004
    ..projects for Drosophila melanogaster and Anopheles gambiae, the initiation of genome sequencing projects for Apis mellifera and Aedes aegypti, the continued development of insect germ-line transformation technology such that for a ..
  11. CRCNS: Importance of temporal information for olfactory codes
    David Terman; Fiscal Year: 2007
    ..The honeybee is an excellent model for studying olfactory processing because honeybees can be conditioned to respond to ..
  12. LYMPHOKINE REGULATION OF HUMAN B CELL MATURATION
    Lloyd Mayer; Fiscal Year: 1991
    ..Two approaches will be used: 1) an allergy desensitization protocol (to honeybee venom) harvesting and activating T cells with specific antigens at various stages of desensitization and 2) ..
  13. Adaptive odor processing
    Benjamin Rubin; Fiscal Year: 2005
    ..This process will be studied in the honeybee olfactory system, a system that is functionally and structurally homologous to the mammalian olfactory system but ..
  14. Evolution of insect gastrulation
    Matthew Ronshaugen; Fiscal Year: 2006
    ..of the Dorsal gradient in Drosophila to understand evolutionary changes in the gastrulation of the honeybee, Apis mellifera. In Drosophila, the ventral-most cells invaginate into the blastocoel and then spread along the internal ..
  15. MARINER TRANSPOSONS OF MAMMALS
    Hugh Robertson; Fiscal Year: 2001
    ..It will also reveal how occasionally particular copies of transposons can become integral parts of their host genetic complements. ..
  16. Gustatory and olfactory receptors of Anopheles gambiae
    Hugh Robertson; Fiscal Year: 2006
    ..This work will also contribute to our overall understanding of the molecular basis of chemoreception in insects and other animals. [unreadable] [unreadable]..
  17. Expression and Modulation of Mast Cell Function in Asthma
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ....
  18. Cholinergic modulation of olfactory processing
    Christiane Linster; Fiscal Year: 2007
    ..These data should provide important insights into how neurodegenerative diseases affect olfactory sensation. [unreadable] [unreadable] [unreadable]..
  19. Cholinergic modulation of odor responses
    Christiane Linster; Fiscal Year: 2003
    ....
  20. REGULATION OF MAST CELL DEVELOPMENT AND FUNCTION
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ..abstract_text> ..
  21. CRCNS: Computational and experimental analysis of noradrenergic function in early
    Christiane Linster; Fiscal Year: 2010
    ..Neuromodulation is involved in many major degenerative diseases of brain function;a better understanding of the functions of these systems will have a high impact on public health. ..
  22. ROLE OF MAST CELLS IN INFLAMMATION AND IMMUNITY
    STEPHEN JOSEPH GALLI; Fiscal Year: 2010
    ..This work promises to improve our understanding of the complex potential roles of MCs, and IgE, in health &disease, as well as to improve our understanding of the pathology of CHS, a common occupational illness. ..
  23. INSECT PROJECTIN: ROLES IN SARCOMERE ASSEMBLY & FLIGHT
    Agnes Ayme Southgate; Fiscal Year: 2005
    ..The main goal is to expose them to the research environment, and to teach them the scientific methods including designing, preparing, performing and analyzing their own experiments. ..
  24. Mast Cells in Physiology, Host Defese and Disease;
    STEPHEN GALLI; Fiscal Year: 2004
    ..Elucidating, at the molecular level, the positive and negative regulation of mast cell development and function; and 7. The development of definitive models for analyzing mast cell function in vivo. ..
  25. MULTIPLE ANTIBIOTIC RESISTANCE (MAR) REGULON
    Stuart Levy; Fiscal Year: 2001
    ....
  26. DYNAMIC REGULATION OF TUNING IN ADULT AUDITORY CORTEX
    NORMAN WEINBERGER; Fiscal Year: 2008
    ..abstract_text> ..
  27. LEARNING-INDUCED CORTICAL REPRESENTATIONAL PLASTICITY
    NORMAN WEINBERGER; Fiscal Year: 2001
    ....
  28. EMOTION AND RETUNING OF AUDITORY CORTEX
    NORMAN WEINBERGER; Fiscal Year: 2002
    ....
  29. MOLECULAR CLONING OF EPITHELIAL K CHANNELS
    Henry Sackin; Fiscal Year: 2008
    ..A thorough characterization of their gating is essential for understanding the molecular basis of a variety of channelopathies. ..
  30. The effect of oxidative stress on muscle damage and functional senesence.
    Jason Williams; Fiscal Year: 2008
    ..I will examine these questions using the honey bee, Apis mellifera. Honey bees are extremely good organisms for studies of exercise induced oxidative stress because they produce ..
  31. Mechanisms for Odor Coding in the Olfactory System
    Maksim Bazhenov; Fiscal Year: 2008
    ..Data from other insects such as honeybee and Drosophila will be used to generalize model predictions...
  32. Neural Mechanism of Visual Associative Learning in Bees
    Angelique Paulk; Fiscal Year: 2007
    ..By investigating visual input to the MBs, this proposed study will represent an initial step in revealing neural mechanisms of visual associative memory. [unreadable] [unreadable]..
  33. EFFLUX-MEDIATED RESISTANCE TO TETRACYCLINES
    Stuart Levy; Fiscal Year: 2006
    ..Such understanding will also enhance[unreadable] efforts to reverse efflux of other antibiotics and drugs used to treat infectious diseases, including[unreadable] bacteria, fungi and parasites, and cancer. ..
  34. Secretion systems for anti-malarial bacterial strains
    David Lampe; Fiscal Year: 2006
    ..Both Type I and Type II secretion systems will be developed and tested. [unreadable] [unreadable] [unreadable]..
  35. The amygdala & cortical receptive field plasticity
    NORMAN WEINBERGER; Fiscal Year: 2006
    ..abstract_text> ..
  36. Computational and Functional Analysis of Gene Networks
    MARC HALFON; Fiscal Year: 2006
    ..abstract_text> ..
  37. Mathematic descriptions - multifactorial gene expression
    Sandra Rodriguez Zas; Fiscal Year: 2006
    ..1) We will generate expression profiles for more than 7000 genes in the brain of the honey bee as a function of its complex pattern of behavioral maturation; samples will be taken every 3-4 days, as it moves ..
  38. Epigenetics of Dietary and Body Fat in Drosophila
    Douglas Ruden; Fiscal Year: 2006
    ..abstract_text> ..
  39. Toxicogenomics of Lead, Mercury, and Cadmium
    Douglas Ruden; Fiscal Year: 2003
    ....
  40. INSECT HEME OXYGENASE
    Boris Dunkov; Fiscal Year: 2004
    ..The organ specific expression will be studied in larvae and in female mosquitoes at various stages before and after blood feeding. ..
  41. EFFLUX-MEDIATED RESISTANCE TO TETRACYCLINES
    Stuart Levy; Fiscal Year: 2004
    ....
  42. GLUTAMATE BIOSYNTHESIS MUTANTS AND ALCOHOL SENSITIVITY
    Douglas Ruden; Fiscal Year: 2003
    ..This genetic approach would eventually lead to a better understanding to a better understanding of the genetic influences that underlie risk for alcoholism. ..
  43. Dominant Mutation that Affect EGF-R Signal Transduction
    Douglas Ruden; Fiscal Year: 2003
    ..It is important to understand regulators of RTK signaling because Ras-Raf dependent neoplasia accounts for as many as one-fifth of all human cancers. ..
  44. The Mechanisms and Regulatory Networks of Alternative Splicing in Drosophila
    BRENTON GRAVELEY; Fiscal Year: 2009
    ....

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