purple sea urchin

Summary

Alias: purple urchin, Strongylocentrotus purpuratus, Strongylocentrotus purpuratus (Stimpson, 1857)

Top Publications

  1. ncbi Characterization and expression of a gene encoding a 30.6-kDa Strongylocentrotus purpuratus spicule matrix protein
    N C George
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Dev Biol 147:334-42. 1991
  2. ncbi Mitochondrial DNA sequences in the nuclear genome of Strongylocentrotus purpuratus
    H T Jacobs
    J Mol Biol 165:609-32. 1983
  3. ncbi Characterization of the SpHE promoter that is spatially regulated along the animal-vegetal axis of the sea urchin embryo
    Z Wei
    Department of Biology, University of Rochester, New York 14627, USA
    Dev Biol 171:195-211. 1995
  4. ncbi Characterization of a homolog of human bone morphogenetic protein 1 in the embryo of the sea urchin, Strongylocentrotus purpuratus
    S P Hwang
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215
    Development 120:559-68. 1994
  5. ncbi Sea urchin genes expressed in activated coelomocytes are identified by expressed sequence tags. Complement homologues and other putative immune response genes suggest immune system homology within the deuterostomes
    L C Smith
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    J Immunol 156:593-602. 1996
  6. ncbi SpRunt-1, a new member of the runt domain family of transcription factors, is a positive regulator of the aboral ectoderm-specific CyIIIA gene in sea urchin embryos
    J A Coffman
    Division of Biology 156 29, California Institute of Technology, Pasadena, California 91125, USA
    Dev Biol 174:43-54. 1996
  7. pmc The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1
    G W Moy
    Marine Biology Research Division, University of California, San Diego, La Jolla 92093 0202, USA
    J Cell Biol 133:809-17. 1996
  8. ncbi Complete sequence of SpHox8 and its linkage in the single Hox gene cluster of Strongylocentrotus purpuratus
    P Martinez
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    J Mol Evol 44:371-7. 1997
  9. ncbi A molecular analysis of hyalin--a substrate for cell adhesion in the hyaline layer of the sea urchin embryo
    G M Wessel
    Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    Dev Biol 193:115-26. 1998
  10. ncbi Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
    R Gauss
    Institut für Biologische Informationsverarbeitung, Forschungszentrum Julich, Germany
    Nature 393:583-7. 1998

Research Grants

  1. Characterization of Aging in Sea Urchin Species with Different Life Spans
    Andrea Bodnar; Fiscal Year: 2012
  2. Comparative analysis of genes required for skeleton formation in sea urchins
    Laura Romano; Fiscal Year: 2009
  3. ROBERT ANDREW CAMERON; Fiscal Year: 2016
  4. ROBERT ANDREW CAMERON; Fiscal Year: 2016
  5. TLR Ectodomains for Microbial Detection and Therapeutics
    Neal Silverman; Fiscal Year: 2013
  6. Notch pathway maintenance of the immortal germ line
    STEVEN ZACHARY SWARTZ; Fiscal Year: 2013
  7. CONFOCAL MICROSCOPE
    Gary Wessel; Fiscal Year: 2003
  8. Mechanism of cytochrome P450 uncoupling and inactivation
    JARED GOLDSTONE; Fiscal Year: 2005
  9. Initiation of Multidrug Transport at Fertilization.
    Amro Hamdoun; Fiscal Year: 2007
  10. CRYO-EM STRUCTURAL STUDIES OF ADENOVIRUS CELL ENTRY
    Phoebe L Stewart; Fiscal Year: 2010

Patents

  1. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
  2. Method of identifying eukaryotic species
  3. Yield increase in plants overexpressing the accdp genes
  4. Method of identifying eukaryotic species
  5. Sequences of an ih ionic channel and the use thereof
  6. KERATIN-BINDING EFFECTOR MOLECULES CONTAINING REACTIVE DYES
  7. Method for couplig keratin-binding polypeptides with effector molecules which support carboxylic groups or sulfonic acid groups
  8. Method for the production of a keratin-binding effector molecule
  9. Proteins associated with abiotic stress response and homologs
  10. Chimeric keratin-binding effector proteins

Detail Information

Publications209 found, 100 shown here

  1. ncbi Characterization and expression of a gene encoding a 30.6-kDa Strongylocentrotus purpuratus spicule matrix protein
    N C George
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Dev Biol 147:334-42. 1991
    ..We describe here the isolation and characterization of several cDNA clones that encode a single 30.6-kDa Strongylocentrotus purpuratus spicule matrix protein designated SM30...
  2. ncbi Mitochondrial DNA sequences in the nuclear genome of Strongylocentrotus purpuratus
    H T Jacobs
    J Mol Biol 165:609-32. 1983
    ....
  3. ncbi Characterization of the SpHE promoter that is spatially regulated along the animal-vegetal axis of the sea urchin embryo
    Z Wei
    Department of Biology, University of Rochester, New York 14627, USA
    Dev Biol 171:195-211. 1995
    ..embryo is established, we have begun to examine the regulatory apparatus of the gene encoding the Strongylocentrotus purpuratus hatching enzyme (SpHE)...
  4. ncbi Characterization of a homolog of human bone morphogenetic protein 1 in the embryo of the sea urchin, Strongylocentrotus purpuratus
    S P Hwang
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215
    Development 120:559-68. 1994
    ..Two models for the possible function of suBMP in spiculogenesis in the sea urchin embryo are discussed...
  5. ncbi Sea urchin genes expressed in activated coelomocytes are identified by expressed sequence tags. Complement homologues and other putative immune response genes suggest immune system homology within the deuterostomes
    L C Smith
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    J Immunol 156:593-602. 1996
    ..Many of the ESTs identified in this study represent the types of genes expected to be used in lower deuterostome immune functions...
  6. ncbi SpRunt-1, a new member of the runt domain family of transcription factors, is a positive regulator of the aboral ectoderm-specific CyIIIA gene in sea urchin embryos
    J A Coffman
    Division of Biology 156 29, California Institute of Technology, Pasadena, California 91125, USA
    Dev Biol 174:43-54. 1996
    ..These results are discussed with reference to known features of the runt domain family of transcription factors...
  7. pmc The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1
    G W Moy
    Marine Biology Research Division, University of California, San Diego, La Jolla 92093 0202, USA
    J Cell Biol 133:809-17. 1996
    ..The lesion in cellular physiology resulting from mutations in the PKD1 protein remains unknown. The homology between REJ modules of the sea urchin REJ and human PKD1 suggests that PKD1 could be involved in ionic regulation...
  8. ncbi Complete sequence of SpHox8 and its linkage in the single Hox gene cluster of Strongylocentrotus purpuratus
    P Martinez
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    J Mol Evol 44:371-7. 1997
    SpHox8 is the paralog group 8 Hox gene of Strongylocentrotus purpuratus. This identification follows from an analysis of the sequence of the complete open reading frame of a late-gastrula-stage cDNA clone; from direct linkage to adjacent ..
  9. ncbi A molecular analysis of hyalin--a substrate for cell adhesion in the hyaline layer of the sea urchin embryo
    G M Wessel
    Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    Dev Biol 193:115-26. 1998
    ..Partial hyalin cDNAs were identified from two sea urchin species, Strongylocentrotus purpuratus and Lytechinus variegatus, by screening expression libraries with monoclonal antibodies to hyalin...
  10. ncbi Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
    R Gauss
    Institut für Biologische Informationsverarbeitung, Forschungszentrum Julich, Germany
    Nature 393:583-7. 1998
    ..Because of their sequence and functional properties, Ih channels form a class of their own within the superfamily of voltage-gated and cyclic-nucleotide-gated channels...
  11. ncbi Coelomocytes express SpBf, a homologue of factor B, the second component in the sea urchin complement system
    L C Smith
    Department of Biological Sciences, Institute of Biomedical Sciences, George Washington University, Washington, DC 20052, USA
    J Immunol 161:6784-93. 1998
    ..been cloned and sequenced from an LPS-activated coelomocyte cDNA library from the purple sea urchin, Strongylocentrotus purpuratus. The deduced amino acid sequence and domain structure show significant similarity to the vertebrate Bf/..
  12. ncbi Origins of immunity: transcription factors and homologues of effector genes of the vertebrate immune system expressed in sea urchin coelomocytes
    Z Pancer
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Immunogenetics 49:773-86. 1999
    ..We conclude that the vertebrate immune system has evolved by inserting new genes into old gene regulatory networks dedicated to immunity...
  13. ncbi NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA
    R Riek
    Institut für Molekularbiolgie und Biophysik, Eidgenossische Technische Hochschule Honggerberg, Zurich, CH 8093, Switzerland
    J Mol Biol 291:417-28. 1999
    The three-dimensional structure of [(113)Cd7]-metallothionein-A (MTA) of the sea urchin Strongylocentrotus purpuratus was determined by homonuclear(1)H NMR experiments and heteronuclear [(1)H, (113)Cd]-correlation spectroscopy...
  14. ncbi SpSoxB1, a maternally encoded transcription factor asymmetrically distributed among early sea urchin blastomeres
    A P Kenny
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Development 126:5473-83. 1999
    ..This factor is the earliest known spatially restricted regulator of transcription along the animal-vegetal axis of the sea urchin embryo...
  15. ncbi New approaches towards an understanding of deuterostome immunity
    J P Rast
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Curr Top Microbiol Immunol 248:3-16. 2000
  16. pmc Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane
    E Monti
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Via Olgettina 58, 20132 Milan, Italy and Department of Biomedical Science and Biotechnology, University of Brescia, Via Valsabbina 19, 25123 Brescia, Italy
    Biochem J 349:343-51. 2000
    ..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane...
  17. pmc Dynamic expression of multiple scavenger receptor cysteine-rich genes in coelomocytes of the purple sea urchin
    Z Pancer
    Division of Biology 156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 97:13156-61. 2000
    ..The mechanisms controlling SRCR gene expression and the functional significance of this dynamic system await elucidation...
  18. ncbi SpKrl: a direct target of beta-catenin regulation required for endoderm differentiation in sea urchin embryos
    E W Howard
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Development 128:365-75. 2001
    ..SpKrl negatively regulates expression of the animalizing transcription factor, SpSoxB1. We propose that SpKrl functions in patterning the vegetal domain by suppressing animal regulatory activities...
  19. ncbi suREJ3, a polycystin-1 protein, is cleaved at the GPS domain and localizes to the acrosomal region of sea urchin sperm
    Kathryn J Mengerink
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0202, USA
    J Biol Chem 277:943-8. 2002
    ..Localization of suREJ3 to the acrosomal region provides the first suggestion for the role of a polycystin-1 protein (components of nonselective cation channels) in a specific cellular process...
  20. ncbi Cloning and developmental expression of a novel, secreted frizzled-related protein from the sea urchin, Strongylocentrotus purpuratus
    Michele R Illies
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Mech Dev 113:61-4. 2002
    ..Here, we describe the cloning of a novel SFRP (suSFRP1) from the sea urchin, Strongylocentrotus purpuratus. SuSFRP1 contains a putative signal sequence, four cysteine-rich domains and a single Ig domain...
  21. ncbi LvDelta is a mesoderm-inducing signal in the sea urchin embryo and can endow blastomeres with organizer-like properties
    Hyla C Sweet
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Development 129:1945-55. 2002
    ..Finally, we find that expression of LvDelta is sufficient to endow blastomeres with the ability to function as a vegetal organizing center and to coordinate the development of a complete pluteus larva...
  22. ncbi The major yolk protein in sea urchins is a transferrin-like, iron binding protein
    Jacqueline M Brooks
    Department of Molecular and Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Dev Biol 245:1-12. 2002
    ..Here we present the primary structure of MYP as predicted from cDNAs of two sea urchins species, Strongylocentrotus purpuratus and Lytechinus variegatus...
  23. ncbi New early zygotic regulators expressed in endomesoderm of sea urchin embryos discovered by differential array hybridization
    Andrew Ransick
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 246:132-47. 2002
    ....
  24. ncbi A regulatory gene network that directs micromere specification in the sea urchin embryo
    Paola Oliveri
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 246:209-28. 2002
    ..This network is a subelement of the overall endomesoderm specification network of the Strongylocentrotus purpuratus embryo...
  25. ncbi Identification and developmental expression of new biomineralization proteins in the sea urchin Strongylocentrotus purpuratus
    Michele R Illies
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Dev Genes Evol 212:419-31. 2002
    ..This work identifies new proteins that may regulate the process of biomineralization in this tractable model system...
  26. ncbi An unusual receptor tyrosine kinase of Schistosoma mansoni contains a Venus Flytrap module
    Jerome Vicogne
    Unité INSERM 547, Institut Pasteur Lille, 1 rue du Pr Calmette, France
    Mol Biochem Parasitol 126:51-62. 2003
    ..The preferential localization of SmRTK-1 in sporocyst germinal cells and ovocytes could be in favor of its function in schistosome growth and differentiation...
  27. pmc Generation, annotation, evolutionary analysis, and database integration of 20,000 unique sea urchin EST clusters
    Albert J Poustka
    Evolution and Development Group, Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, 14195 Berlin, Germany
    Genome Res 13:2736-46. 2003
    ..have analyzed a total of 107,283 cDNA clones of libraries that span the development of the sea urchin Strongylocentrotus purpuratus. Normalization by oligonucleotide fingerprinting, EST sequencing and sequence clustering resulted in ..
  28. pmc Regulated proteolysis by cortical granule serine protease 1 at fertilization
    Sheila A Haley
    Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, RI 02916, USA
    Mol Biol Cell 15:2084-92. 2004
    ..protease, cortical granule serine protease 1 (CGSP1), has been identified in the cortical granules of Strongylocentrotus purpuratus eggs, and here we examined the regulation of the protease activity and tested potential target ..
  29. ncbi Two cDNAs from the purple sea urchin, Strongylocentrotus purpuratus, encoding mosaic proteins with domains found in factor H, factor I, and complement components C6 and C7
    Keri A Multerer
    Graduate Program in Genetics, The Institute of Biomedical Sciences, George Washington University, Washington, DC 20052, USA
    Immunogenetics 56:89-106. 2004
    ..Purple sea urchin, Strongylocentrotus purpuratus, homologues of complement C3 (SpC3) and factor B (SpBf) have been identified, suggesting the presence ..
  30. ncbi Expression patterns of four different regulatory genes that function during sea urchin development
    Takuya Minokawa
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Gene Expr Patterns 4:449-56. 2004
    The spatial and temporal expression patterns of Strongylocentrotus purpuratus genes encoding four different transcription factors, viz...
  31. ncbi On the origin of the chordate central nervous system: expression of onecut in the sea urchin embryo
    Albert J Poustka
    Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Evolution and Development Group, Ihnestrasse 73, 14195 Berlin, Germany
    Evol Dev 6:227-36. 2004
    We identified a transcription factor of the onecut class in the sea urchin Strongylocentrotus purpuratus that represents an ortholog of the mammalian gene HNF6, the founding member of the onecut class of proteins...
  32. ncbi Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages
    Athula H Wikramanayake
    Department of Zoology, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    Genesis 39:194-205. 2004
    ..Here, we show that SpWnt8, a Wnt8 homolog from Strongylocentrotus purpuratus, is zygotically activated specifically in 16-cell-stage micromeres in a nuclear beta-catenin-dependent ..
  33. pmc An ancient evolutionary origin of the Rag1/2 gene locus
    Sebastian D Fugmann
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 103:3728-33. 2006
    ..a closely linked pair of genes, SpRag1L and SpRag2L, from an invertebrate, the purple sea urchin (Strongylocentrotus purpuratus) with similarity in both sequence and genomic organization to the vertebrate Rag1 and Rag2 genes...
  34. ncbi Unexpected diversity displayed in cDNAs expressed by the immune cells of the purple sea urchin, Strongylocentrotus purpuratus
    David P Terwilliger
    Department of Biological Sciences, George Washington University, Washington, District of Columbia 20052, USA
    Physiol Genomics 26:134-44. 2006
    ..Two 185/333 genes, identified in the partially assembled Strongylocentrotus purpuratus genome, have two exons...
  35. ncbi Identification and developmental expression of the ets gene family in the sea urchin (Strongylocentrotus purpuratus)
    Francesca Rizzo
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Dev Biol 300:35-48. 2006
    A systematic search in the available scaffolds of the Strongylocentrotus purpuratus genome has revealed that this sea urchin has 11 members of the ets gene family...
  36. pmc Distinctive expression patterns of 185/333 genes in the purple sea urchin, Strongylocentrotus purpuratus: an unexpectedly diverse family of transcripts in response to LPS, beta-1,3-glucan, and dsRNA
    David P Terwilliger
    Department of Biological Sciences, George Washington University, Washington, DC, USA
    BMC Mol Biol 8:16. 2007
    ..Individual sea urchins were challenged with pathogen associated molecular patterns (PAMPs) (lipopolysaccharide, beta-1,3-glucan, or double stranded RNA), and changes in the 185/333 message repertoire were followed over time...
  37. pmc Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio)
    Marta Manzoni
    Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Biochem J 408:395-406. 2007
    ..Overall, the redundancy of sialidases together with their expression profile and their activity exerted on gangliosides of living cells indicate the biological relevance of this class of enzymes in zebrafish...
  38. doi Highly variable immune-response proteins (185/333) from the sea urchin, Strongylocentrotus purpuratus: proteomic analysis identifies diversity within and between individuals
    Nolwenn M Dheilly
    Department of Biological Sciences, Macquarie University, North Ryde, New South Wales, Australia
    J Immunol 182:2203-12. 2009
    185/333 genes and transcripts from the purple sea urchin, Strongylocentrotus purpuratus, predict high levels of amino acid diversity within the encoded proteins...
  39. doi Simultaneous positive and negative frequency-dependent selection on sperm bindin, a gamete recognition protein in the sea urchin Strongylocentrotus purpuratus
    Don R Levitan
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Evolution 64:785-97. 2010
    ..We explored how variation in sperm bindin influences reproductive success of the sea urchin Strongylocentrotus purpuratus during group spawning in the sea...
  40. doi SpTie1/2 is expressed in coelomocytes, axial organ and embryos of the sea urchin Strongylocentrotus purpuratus, and is an orthologue of vertebrate Tie1 and Tie2
    Margaret E Stevens
    Department of Biology, Ripon College, Ripon Wisconsin, United States
    Dev Comp Immunol 34:884-95. 2010
    ..We speculate that SpTie1/2 may be involved in the proliferation of sea urchin immune cells in both adults and embryos...
  41. pmc Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops
    Edoardo Giacopuzzi
    Department of Biomedical Sciences and Biotechnology, Unit of Biology and Genetics, University of Brescia, Viale Europa 11, Brescia 25123, Italy
    BMC Biochem 12:45. 2011
    ..These features prompted us to extend our studies on this protein family in birds, to get insights on the evolution of this class of glycohydrolases...
  42. pmc ATP-binding cassette (ABC) transporter expression and localization in sea urchin development
    Lauren E Shipp
    Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, California 92093 0202, USA
    Dev Dyn 241:1111-24. 2012
    ..There are >100 ABC transporter predictions in the Strongylocentrotus purpuratus genome, including 40 annotated ABCB, ABCC, and ABCG "multidrug efflux" transporters...
  43. pmc What is the core oscillator in the speract-activated pathway of the Strongylocentrotus purpuratus sperm flagellum?
    Luis U Aguilera
    Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Unidad Monterrey, Parque de Investigación e Innovación Tecnológica, Apodaca, Mexico
    Biophys J 102:2481-8. 2012
    ..from a mathematical modeling perspective, that the reported speract-activated signaling pathway in Strongylocentrotus purpuratus (speract being a sperm-activating peptide specific to this species) has the necessary elements to ..
  44. pmc Actin polymerization controls the activation of multidrug efflux at fertilization by translocation and fine-scale positioning of ABCB1 on microvilli
    Kristen Whalen
    Marine Biology Research Division, Scripps Institution of Oceanography, La Jolla, CA 92093, USA
    Mol Biol Cell 23:3663-72. 2012
    ....
  45. ncbi Spec2 genes of Strongylocentrotus purpuratus. Structure and differential expression in embryonic aboral ectoderm cells
    P E Hardin
    Department of Biochemistry and Molecular Biology, M D Anderson Hospital and Tumor Institute, University of Texas, Houston 77030
    J Mol Biol 202:417-31. 1988
    Members of the Spec gene family are expressed during embryonic development of the sea urchin, Strongylocentrotus purpuratus. The family encodes proteins related to the calmodulin/troponin C/myosin light chain group of calcium binding ..
  46. ncbi Sea urchin actin gene subtypes. Gene number, linkage and evolution
    J J Lee
    J Mol Biol 172:149-76. 1984
    The actin gene family of the sea urchin Strongylocentrotus purpuratus was analyzed by the genome blot method, using subcloned probes specific to the 3' terminal non-translated actin gene sequence, intervening sequence and coding region ..
  47. ncbi Two Otx proteins generated from multiple transcripts of a single gene in Strongylocentrotus purpuratus
    X Li
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 187:253-66. 1997
    ..In the sea urchin, Strongylocentrotus purpuratus, an orthodenticle-related protein called SpOtx is believed to direct the activation of the aboral ..
  48. ncbi Characterization of the sea urchin major vault protein: a possible role for vault ribonucleoprotein particles in nucleocytoplasmic transport
    D R Hamill
    Department of Biochemistry, Cell and Molecular Biology, University of Kansas, Lawrence 66045, USA
    Dev Biol 190:117-28. 1997
    ..Based on their copurification and intracellular distribution, vaults may be involved in the nucleocytoplasmic transport of ribosomes and/or mRNA...
  49. ncbi Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family
    E Monti
    Department of Biomedical Science and Biotechnology, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Genomics 83:445-53. 2004
    ..Immunofluorescence staining and Western blot analysis demonstrated the association of NEU4 with the inner cell membranes...
  50. ncbi Polycystin-2 associates with the polycystin-1 homolog, suREJ3, and localizes to the acrosomal region of sea urchin spermatozoa
    Anna T Neill
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA
    Mol Reprod Dev 67:472-7. 2004
    ..The low cation selectivity of PC2 channels would explain data indicating that Na(+) and Ca(2+) may enter sea urchin sperm through the same channel during the acrosome reaction...
  51. ncbi A third sea urchin sperm receptor for egg jelly module protein, suREJ2, concentrates in the plasma membrane over the sperm mitochondrion
    Blanca E Galindo
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0202, USA
    Dev Growth Differ 46:53-60. 2004
    ..In the present study, we describe the sequence, domain structure and localization of suREJ2 and speculate on its possible function...
  52. ncbi Constitutive expression and alternative splicing of the exons encoding SCRs in Sp152, the sea urchin homologue of complement factor B. Implications on the evolution of the Bf/C2 gene family
    David P Terwilliger
    Department of Biological Sciences, The George Washington University, Lisner Hall 340, 2023 G Street, NW, Washington, DC 20052, USA
    Immunogenetics 56:531-43. 2004
    The purple sea urchin, Strongylocentrotus purpuratus, possesses a non-adaptive immune system including elements homologous to C3 and factor B (Bf) of the vertebrate complement system...
  53. ncbi Expression of Spgatae, the Strongylocentrotus purpuratus ortholog of vertebrate GATA4/5/6 factors
    Pei Yun Lee
    Division of Biology, California Institute of Technology, 1200 E California Blvd, Mail Code 156 29, Pasadena, CA 91125, USA
    Gene Expr Patterns 5:161-5. 2004
    ..Towards the end of embryogenesis, expression in the hindgut decreases. The terminal pattern of expression is in midgut plus coelomic pouches...
  54. ncbi Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo
    Paola Oliveri
    Division of Biology, 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Development 133:4173-81. 2006
    ..component of the endoderm specification subcircuit of the endomesoderm gene regulatory network in the Strongylocentrotus purpuratus embryo...
  55. pmc Extraordinary diversity among members of the large gene family, 185/333, from the purple sea urchin, Strongylocentrotus purpuratus
    Katherine M Buckley
    George Washington University, Department of Biological Sciences, Washington, DC 20052, USA
    BMC Mol Biol 8:68. 2007
    ..Therefore, the immune response of the purple sea urchin appears to be more complex than previously believed...
  56. pmc SpCoel1: a sea urchin profilin gene expressed specifically in coelomocytes in response to injury
    L C Smith
    Division of Biology, California Institute of Technology, Pasadena 91125
    Mol Biol Cell 3:403-14. 1992
    ..copy gene that is specifically expressed in most of the coelomocytes of the adult purple sea urchin, Strongylocentrotus purpuratus. The 4-kb transcript from this gene has a relatively short (426 nucleotide) open reading frame (ORF) ..
  57. pmc Molecular cloning of the first metazoan beta-1,3 glucanase from eggs of the sea urchin Strongylocentrotus purpuratus
    E S Bachman
    Developmental Cell and Molecular Biology Group, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 93:6808-13. 1996
    ..sequences were obtained from beta-1,3 glucanase that had been purified from eggs of the sea urchin Strongylocentrotus purpuratus and the gene was cloned by PCR using oligonucleotides deduced from the peptide sequences...
  58. ncbi SpHbox7, a new Abd-B class homeobox gene from the sea urchin Strongylocentrotus purpuratus: insights into the evolution of hox gene expression and function
    S L Dobias
    Department of Biochemistry, University of Southern California, School of Medicine, Los Angeles 90033, USA
    Dev Dyn 207:450-60. 1996
    ..we describe the isolation, sequences analysis and spatiotemporal expression pattern of a sea urchin (Strongylocentrotus purpuratus) Abd-B-like gene, designated SpHbox7...
  59. ncbi The cortical granule serine protease CGSP1 of the sea urchin, Strongylocentrotus purpuratus, is autocatalytic and contains a low-density lipoprotein receptor-like domain
    S A Haley
    Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, 02912, USA
    Dev Biol 211:1-10. 1999
    ..We used this finding to identify a cDNA clone from a Strongylocentrotus purpuratus ovary cDNA library that encodes a 581-amino-acid-residue protein that we refer to as cortical granule ..
  60. ncbi Identification of kinesin-C, a calmodulin-binding carboxy-terminal kinesin in animal (Strongylocentrotus purpuratus) cells
    G C Rogers
    Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    J Mol Biol 294:1-8. 1999
    ..The presence of this novel calmodulin-binding motor in sea urchin embryos suggests that it plays a critical role in Ca(2+)-dependent events during early sea urchin development...
  61. ncbi Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family
    Jared V Goldstone
    Department of Biology, Woods Hole Oceanographic Institution, Woods Hole
    Mol Biol Evol 24:2619-31. 2007
    ..Subsequently, 10 CYP1-like genes were found in the echinoderm Strongylocentrotus purpuratus (sea urchin) genome...
  62. ncbi Conservation of the WD-repeat, microtubule-binding protein, EMAP, in sea urchins, humans, and the nematode C. elegans
    K A Suprenant
    Department of Molecular Biosciences, 4010 Haworth Hall, University of Kansas, Lawrence, KS 66045, USA
    Dev Genes Evol 210:2-10. 2000
    ..To identify conserved functional domains, we compared the predicted amino acid sequence encoded by Strongylocentrotus purpuratus and Lytechinus variegatus EMAP cDNAs, and determined that these two sea urchin EMAPs were 95% ..
  63. ncbi Caught in the evolutionary act: precise cis-regulatory basis of difference in the organization of gene networks of sea stars and sea urchins
    Veronica F Hinman
    Department of Biological Sciences, Carnegie Mellon University, PA 15213, USA
    Dev Biol 312:584-95. 2007
    The regulatory control of otxbeta1/2 in the sea urchin Strongylocentrotus purpuratus and the sea star Asterina miniata provides an exceptional opportunity to determine the genomic basis of evolutionary change in gene regulatory network (..
  64. doi Evolutionary analysis of the cis-regulatory region of the spicule matrix gene SM50 in strongylocentrotid sea urchins
    Jenna Walters
    Department of Biology, Denison University, Granville, OH 43023, USA
    Dev Biol 315:567-78. 2008
    ..of SM50, which has already been characterized to a considerable extent in the purple sea urchin, Strongylocentrotus purpuratus. We have isolated the cis-regulatory region from 15 individuals of S...
  65. pmc Analysis of cytoskeletal and motility proteins in the sea urchin genome assembly
    R L Morris
    Department of Biology, Wheaton College, Norton, MA 02766, USA
    Dev Biol 300:219-37. 2006
    ..We have conducted an analysis of gene models derived from the Strongylocentrotus purpuratus genome assembly and have gathered strong evidence for the existence of multiple gene families encoding ..
  66. ncbi Runx transcription factors and the developmental balance between cell proliferation and differentiation
    James A Coffman
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA
    Cell Biol Int 27:315-24. 2003
    ..Runx transcription factors include the nematode Caenorhabditis elegans and the sea urchin Strongylocentrotus purpuratus, each of which apparently contains only a single Runx gene...
  67. doi Substratum cavities affect growth-plasticity, allometry, movement and feeding rates in the sea urchin Strongylocentrotus purpuratus
    J C Hernandez
    Department of Biology, 800 Lancaster Avenue, Villanova University, PA 19085, USA
    J Exp Biol 213:520-5. 2010
    ..the influence of rock cavities, or pits, on the growth dynamics and behavior of the purple sea urchin, Strongylocentrotus purpuratus. In a paired-designed, laboratory experiment, sea urchins were assigned to sandstone blocks that were ..
  68. pmc Comparison of the receptor FGFRL1 from sea urchins and humans illustrates evolution of a zinc binding motif in the intracellular domain
    Lei Zhuang
    Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    BMC Biochem 10:33. 2009
    ....
  69. ncbi Isolation and characterization of developmentally regulated sea urchin U2 snRNA genes
    B Stefanovic
    Department of Chemistry, Florida State University, Tallahassee 32306
    Dev Biol 148:284-94. 1991
    Genes encoding the U2 snRNA have been isolated from the sea urchins, Strongylocentrotus purpuratus and Lytechinus variegatus...
  70. doi Detached kelps from distant sources are a food subsidy for sea urchins
    Mathew A Vanderklift
    CSIRO Marine and Atmospheric Research, Wembley, WA 6913, Australia
    Oecologia 157:327-35. 2008
    ..We demonstrate trophic linkages between detached (drift) fragments of the kelp Ecklonia radiata and the purple sea urchin Heliocidaris erythrogramma among discrete rocky reefs separated by kilometres...
  71. ncbi Sea urchin granuloma secondary to Strongylocentrotus purpuratus and Strongylocentrotus franciscanus
    Filamer D Kabigting
    Department of Dermatology, University of California at San Diego, San Diego, California, USA
    Dermatol Online J 15:9. 2009
    ..granulomas, the two most prevalent organisms found on the US West Coast, purple and red sea urchins (Strongylocentrotus purpuratus and Strongylocentrotus franciscanus), have not yet been reported to induce persistent granulomatosis ..
  72. ncbi Skeletogenesis in sea urchin interordinal hybrid embryos
    B P Brandhorst
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
    Cell Tissue Res 305:159-67. 2001
    Reciprocal interordinal crosses were made between the sea urchins Strongylocentrotus purpuratus and Lytechinus pictus. Previous research indicated that the expression of many L. pictus genes is reduced in the hybrid embryos. The S...
  73. ncbi Shedding genomic light on Aristotle's lantern
    Erica Sodergren
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1519, Houston, TX 77030, USA
    Dev Biol 300:2-8. 2006
    ..Now, the genome of the sea urchin Strongylocentrotus purpuratus is the first echinoderm genome to be sequenced...
  74. ncbi Sequence, annotation and developmental expression of the sea urchin Ca(2+) -ATPase family
    H Jayantha Gunaratne
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0202, USA
    Gene 397:67-75. 2007
    ..The primary structures of Sp-PMCA and Sp-SERCA in the sea urchin, Strongylocentrotus purpuratus (Sp), have been published...
  75. doi Gamete traits influence the variance in reproductive success, the intensity of sexual selection, and the outcome of sexual conflict among congeneric sea urchins
    Don R Levitan
    Department of Biological Science, Florida State University, Tallahassee, Florida 32306, USA
    Evolution 62:1305-16. 2008
    ..The eggs of the species occurring at higher densities, Strongylocentrotus purpuratus, require higher sperm concentrations for fertilization but are more resistant to polyspermy compared ..
  76. ncbi Reproduction on the edge: large-scale patterns of individual performance in a marine invertebrate
    Sarah E Lester
    Department of Ecology, Evolution, and Marine Biology, University of California, Santa Barbara, California 93106, USA
    Ecology 88:2229-39. 2007
    ..geographic patterns in reproductive output for intertidal populations of the purple sea urchin, Strongylocentrotus purpuratus, at 15 sites spanning a large geographic distance (9 degrees span of latitude) from central California,..
  77. pmc An evolutionary transition of Vasa regulation in echinoderms
    Celina E Juliano
    Department of Molecular and Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Evol Dev 11:560-73. 2009
    ..In the embryo of the sea urchin Strongylocentrotus purpuratus, Vasa protein is posttranscriptionally enriched in the small micromere lineage, which results from two ..
  78. ncbi Ecological role of purple sea urchins
    John S Pearse
    Long Marine Laboratory, University of California, Santa Cruz, 100 Shaffer Road, Santa Cruz, CA 95060, USA
    Science 314:940-1. 2006
    ..Their grazing limits algal biomass, and they are preyed upon by many predators. Purple sea urchins (Strongylocentrotus purpuratus) are among the best studied species...
  79. doi Identification of protein components from the mature ovary of the sea urchin Evechinus chloroticus (Echinodermata: Echinoidea)
    Mary A Sewell
    School of Biological Sciences, University of Auckland, Auckland, New Zealand
    Proteomics 8:2531-42. 2008
    ..product, contained 138 proteins that were identified from the recently completed sea urchin genome (Strongylocentrotus purpuratus) with high confidence...
  80. ncbi Embryonic expression of engrailed in sea urchins
    Shunsuke Yaguchi
    Department of Biology, University of Victoria, 3800 Finnerty Road, Victoria, BC, Canada
    Gene Expr Patterns 6:566-71. 2006
    ..We have used genomic resources to clone an engrailed gene (SpEn) from Strongylocentrotus purpuratus, and with this we have developed an antibody specific for SpEn...
  81. pmc Majority of divergence between closely related DNA samples is due to indels
    Roy J Britten
    California Institute of Technology, 101 Dahlia Avenue, Corona del Mar, CA 92625, USA
    Proc Natl Acad Sci U S A 100:4661-5. 2003
    ..is similar evidence of a large value of R(u) for sea urchins from the polymorphism of a sample of Strongylocentrotus purpuratus DNA (R(u) = 3-4)...
  82. ncbi A developmental switch in sea urchin U1 RNA
    M A Nash
    Department of Chemistry, Florida State University, Tallahassee 32306
    Dev Biol 134:289-96. 1989
    ..of U1 RNA has been determined in the eggs and embryos of two sea urchins, Lytechinus variegatus and Strongylocentrotus purpuratus. In both species the sequence of the U1 RNA changes as the embryos progress through development...
  83. doi Diversification of innate immune genes: lessons from the purple sea urchin
    L Courtney Smith
    Department of Biological Sciences, George Washington University, 2023 G Street NW, Washington, DC 20052, USA
    Dis Model Mech 3:274-9. 2010
    ..a seemingly unlikely source for insight into innate immune diversification may be derived from the purple sea urchin, which has recently had its genome sequenced and annotated...
  84. pmc SpBase: the sea urchin genome database and web site
    R Andrew Cameron
    Center for Computational Regulatory Genomics, Beckman Institute 139 74, California Institute of Technology, Pasadena, CA 91104, USA
    Nucleic Acids Res 37:D750-4. 2009
    ..served from the databases emerges from the draft genomic sequence of the purple sea urchin, Strongylocentrotus purpuratus and includes sequence data and genomic resource descriptions for other members of the echinoderm clade ..
  85. ncbi Utilization of the aquatic research facility and fertilization syringe unit to study sea urchin development in space
    H Schatten
    Department of Veterinary Pathobiology, University of Missouri Columbia 65211, USA
    J Gravit Physiol 6:43-53. 1999
    ..Eggs and embryos of either the sea urchin species Lytechinus pictus or Strongylocentrotus purpuratus were loaded into Standard Container Assemblies (SCAs) which comprised the experimental aquaria (33 mL ..
  86. doi Strongylocins, novel antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis
    Chun Li
    Department of Marine Biotechnology, The Norwegian College of Fishery Science, University of Tromsø, Breivika, N 9037 Tromsø, Norway
    Dev Comp Immunol 32:1430-40. 2008
    ..named strongylocins 1 and 2) have putative isoforms (1b and 2b), similar to two putative proteins from the purple sea urchin S. purpuratus...
  87. pmc Extracellular matrix modifications at fertilization: regulation of dityrosine crosslinking by transamidation
    Julian L Wong
    Department of Molecular Biology, Brown University, Providence, RI 02912, USA
    Development 136:1835-47. 2009
    ..Here, we identify the Strongylocentrotus purpuratus enzymes responsible for the formation of epsilon(gamma-glutamyl)lysine crosslinks (transamidation)...
  88. ncbi Nutritive phagocyte incubation chambers provide a structural and nutritive microenvironment for germ cells of Strongylocentrotus droebachiensis, the green sea urchin
    Charles W Walker
    Department of Zoology, Marine Biomedical Research Group, Center for Marine Biology, University of New Hampshire, Durham, New Hampshire 03824, USA
    Biol Bull 209:31-48. 2005
    ..purpuratus, the closely related purple sea urchin.
  89. pmc A putative 'pre-nervous' endocannabinoid system in early echinoderm development
    G A Buznikov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
    Dev Neurosci 32:1-18. 2010
    Embryos and larvae of sea urchins (Lytechinus variegatus, Strongylocentrotus droebachiensis, Strongylocentrotus purpuratus, Dendraster excentricus), and starfish (Pisaster ochraceus) were investigated for the presence of a functional ..
  90. ncbi The role of lysyl oxidase and collagen crosslinking during sea urchin development
    E Butler
    Department of Biological Sciences, California State University, Hayward 94542
    Exp Cell Res 173:174-82. 1987
    ..the only enzyme involved in collagen crosslinking, is shown to be present in embryos of the sea urchin Strongylocentrotus purpuratus. The enzyme specific activity increases over six-fold during development, showing the greatest rise ..
  91. ncbi Functional organization of DNA elements regulating SM30alpha, a spicule matrix gene of sea urchin embryos
    K Yamasu
    Department of Regulation Biology, Faculty of Science, Saitama University, Urawa, Japan
    Dev Growth Differ 41:81-91. 1999
    The SM30a gene encodes a protein in the embryonic endoskeleton of the sea urchin Strongylocentrotus purpuratus, and is specifically expressed in the skeletogenic primary mesenchyme cell lineage...
  92. doi Mechanism of calcite co-orientation in the sea urchin tooth
    Christopher E Killian
    Department of Physics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Am Chem Soc 131:18404-9. 2009
    ..Here, we show differences in calcite c-axis orientations in the tooth of the purple sea urchin ( Strongylocentrotus purpuratus ), using high-resolution X-ray photoelectron emission spectromicroscopy (X-PEEM) and microbeam X-ray ..
  93. ncbi Structure, regulation, and function of micro1 in the sea urchin Hemicentrotus pulcherrimus
    Yukiko Nishimura
    Division of Life Science, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, 920 1192, Japan
    Dev Genes Evol 214:525-36. 2004
    ..of paired-like class homeobox genes, along with PlHbox12 from Paracentrotus lividus and pmar1 from Strongylocentrotus purpuratus. In the present study, we showed that micro1 is a multicopy gene with six or more polymorphic loci, at ..
  94. pmc Demosponge EST sequencing reveals a complex genetic toolkit of the simplest metazoans
    Matija Harcet
    Department of Molecular Biology, Rudjer Boskovic Institute, Zagreb, Croatia
    Mol Biol Evol 27:2747-56. 2010
    ..well-characterized metazoans--Nematostella vectensis, Caenorhabditis elegans, Drosophila melanogaster, Strongylocentrotus purpuratus, Ciona intestinalis, and Homo sapiens...
  95. ncbi Complete sequence of the mitochondrial DNA in the sea urchin Arbacia lixula: conserved features of the echinoid mitochondrial genome
    C De Giorgi
    Dipartimento di Biochimica e Biologia Molecolare, University of Bari, Italy
    Mol Phylogenet Evol 5:323-32. 1996
    ..The comparison of the entire sequences of mtDNA among A. lixula, Paracentrotus lividus, and Strongylocentrotus purpuratus allowed us to detect peculiar features, common to the three sea urchin species, that can represent the ..
  96. pmc Phosphoproteomes of Strongylocentrotus purpuratus shell and tooth matrix: identification of a major acidic sea urchin tooth phosphoprotein, phosphodontin
    Karlheinz Mann
    Max Planck Institut fur Biochemie, Abteilung Proteomics und Signaltransduktion, D 82152 Martinsried, Am Klopferspitz 18, Germany
    Proteome Sci 8:6. 2010
    ..in the embryo and adult, and the molecular characterization of such proteins, has just gained momentum with the sequencing of the Strongylocentrotus purpuratus genome and the introduction of high-throughput proteomics into the field.
  97. ncbi Methods for karyotyping and for localization of developmentally relevant genes on the chromosomes of the purple sea urchin, Strongylocentrotus purpuratus
    Celeste C Eno
    Molecular, Cellular and Biomedical Sciences, University of New Hampshire, 46 College Road, Durham, New Hampshire 03824, USA
    Biol Bull 217:306-12. 2009
    The purple sea urchin, Strongylocentrotus purpuratus, is the only non-chordate deuterostome model with a fully sequenced genome...
  98. pmc Cis-regulatory control of the nodal gene, initiator of the sea urchin oral ectoderm gene network
    Jongmin Nam
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Dev Biol 306:860-9. 2007
    ..This gene encodes a TGFbeta ligand, and in Strongylocentrotus purpuratus its transcription is activated in the presumptive oral ectoderm at about the 30-cell stage...
  99. pmc Microplate assay for quantifying developmental morphologies: effects of exogenous hyalin on sea urchin gastrulation
    Z Razinia
    Department of Biology, California State University, Northridge, 18111 Nordhoff Street, Northridge, CA 91330 8303, USA
    Zygote 15:159-64. 2007
    ..Using wide-mouthed pipette tips, 25 microl of 24-h Strongylocentrotus purpuratus embryos were transferred to each well of a 96-well polystyrene flat-bottom microplate yielding about ..
  100. ncbi Reduction of the fertilizing capacity of sea urchin sperm by cannabinoids derived from marihuana. I. Inhibition of the acrosome reaction induced by egg jelly
    H Schuel
    Department of Anatomical Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY 14214
    Mol Reprod Dev 29:51-9. 1991
    ..from marihuana--cannabidiol (CBD) and cannabinol (CBN)--inhibit fertilization in the sea urchin Strongylocentrotus purpuratus by reducing the fertilizing capacity of sperm (Schuel et al., 1987)...
  101. ncbi Molecular characterisation of SALMFamide neuropeptides in sea urchins
    Maurice R Elphick
    School of Biological and Chemical Sciences, Queen Mary, University of London, UK
    J Exp Biol 208:4273-82. 2005
    ..for identification of echinoid SALMFamides was provided by sequencing the genome of the sea urchin Strongylocentrotus purpuratus. Analysis of whole-genome shotgun sequence data using the Basic Local Alignment Search Tool (BLAST) ..

Research Grants29

  1. Characterization of Aging in Sea Urchin Species with Different Life Spans
    Andrea Bodnar; Fiscal Year: 2012
    ..urchins species with different life spans;Strongylocentrotus franciscanus (life span >100 years), Strongylocentrotus purpuratus (life span 50 years) and Lytechinus variegatus (life span 4 years)...
  2. Comparative analysis of genes required for skeleton formation in sea urchins
    Laura Romano; Fiscal Year: 2009
    ..purpuratus (the "purple urchin"), and to evaluate the role of natural selection in producing this variation...
  3. ROBERT ANDREW CAMERON; Fiscal Year: 2016
    ..This revised proposal seeks support for the Gene Library Resource for the purple sea urchin, Strongylocentrotus purpuratus. This Resource provides the essential infrastructure, new technology, molecular biology support ..
  4. ROBERT ANDREW CAMERON; Fiscal Year: 2016
    ..is to gather, collate and present genomic information for echinoderm species including the reference, Strongylocentrotus purpuratus (Sp) through an easily managed web information system (http://spbase.org)...
  5. TLR Ectodomains for Microbial Detection and Therapeutics
    Neal Silverman; Fiscal Year: 2013
    ..In addition to mammalian TLRs/NLRs, the purple sea urchin (Strongylocentrotus purpuratus) has a greatly expanded repertoire of pattern recognition receptors, in lieu of an adaptive immune ..
  6. Notch pathway maintenance of the immortal germ line
    STEVEN ZACHARY SWARTZ; Fiscal Year: 2013
    ..SpMibL, enriched in the presumptive germ cells called small micromeres (SMMs) of the sea urchin Strongylocentrotus purpuratus. These cells are allocated early in early development and are used to construct adult tissues during ..
  7. CONFOCAL MICROSCOPE
    Gary Wessel; Fiscal Year: 2003
    ..The requested instrument would significantly enhance the research productivity of the broad, interdisciplinary community of researchers described here, and greatly improve the biological image capabilities in the region. ..
  8. Mechanism of cytochrome P450 uncoupling and inactivation
    JARED GOLDSTONE; Fiscal Year: 2005
    ..Recently identified AhR-agonistic persistent pollutants, such as polybrominated diphenyl ethers will also be investigated. ..
  9. Initiation of Multidrug Transport at Fertilization.
    Amro Hamdoun; Fiscal Year: 2007
    ..abstract_text> ..
  10. CRYO-EM STRUCTURAL STUDIES OF ADENOVIRUS CELL ENTRY
    Phoebe L Stewart; Fiscal Year: 2010
    ..Understanding the molecular principles of this natural defense mechanism could lead to novel strategies for antiviral drug design. ..
  11. Redox-sensitive developmental pathways and gene regulatory networks
    JAMES COFFMAN; Fiscal Year: 2009
    ..Finally, the Comparative Toxicogenomics Database (CTD) at MDIBL will be used to determine the relevance of the pathways discovered in sea urchins to human health, and to generate hypotheses that might explain specific human diseases. ..
  12. Control of Cell Proliferation by Runx Proteins
    JAMES COFFMAN; Fiscal Year: 2009
    ..Unlike mammals, which have 3 Runx genes, the sea urchin Strongylocentrotus purpuratus has only a single Runx gene (SpRunt)...
  13. Spiralian developmental system for the study of multipotency
    Cesar Arenas Mena; Fiscal Year: 2008
    ..The ultimate goal is to manipulate these genes and reprogram in vivo differentiated cells into multipotent stem cells. [unreadable] [unreadable] [unreadable]..
  14. Regulatory Genomics: BAC-GFP Library of Control Genes
    Eric Davidson; Fiscal Year: 2008
    ..vectors of all transcription factors expressed significantlyin the embryo of the sea urchin, Strongylocentrotus purpuratus, the genomic sequence of which will go on line shortly...
  15. Misregulation of apoptosis in cloned pig embryos
    Heide Schatten; Fiscal Year: 2007
    ..Pilot data from this R03 small grants program research will be used to apply for funding through the R01 mechanism. [unreadable] [unreadable] [unreadable]..
  16. Nogo Receptor Signaling and Function
    Mark Bothwell; Fiscal Year: 2007
    ..Effects of these manipulations on axonal targeting will be assessed by injecting the fluorescent marker Dil into embryos to allow microscopic imaging of axon trajectories. ..
  17. MARINER TRANSPOSONS OF MAMMALS
    Hugh Robertson; Fiscal Year: 2001
    ..It will also reveal how occasionally particular copies of transposons can become integral parts of their host genetic complements. ..
  18. Amyloid Precursor Protein Signaling
    Mark Bothwell; Fiscal Year: 2006
    ..Effects of agonistic APP monoclonal antibody, beta-amyloid peptide, LRP, and alpha-2 macroglobulin on APP signaling will be assessed. ..
  19. Gustatory and olfactory receptors of Anopheles gambiae
    Hugh Robertson; Fiscal Year: 2006
    ..This work will also contribute to our overall understanding of the molecular basis of chemoreception in insects and other animals. [unreadable] [unreadable]..
  20. NEUROTROPHIN RECEPTOR INTERACTIONS
    Mark Bothwell; Fiscal Year: 2004
    ..The patterns of developmental expression of P75/NTR, NRH1 and NRH2 will be examined in Xenopus and mice, to assess whether the opportunity for functional interactions exist. ..
  21. Cytoplasmic Reactivation of p53 Family Members
    Charles Walker; Fiscal Year: 2004
    ..Overexpression might overwhelm mechanisms that sequester these proteins in the cytoplasm of leukemic clam hemocytes and lead to a resumption of clam p53 and/or p63/73-induced apoptosis. ..
  22. Cytoskeletal organization in apicomplexan parasites
    Heide Schatten; Fiscal Year: 2005
    ..Pilot data from this RO3 research will be used to apply for funding through the RO1 mechanism. ..
  23. Mitochondria distribution in cloned pig embryos
    Heide Schatten; Fiscal Year: 2005
    ..Pilot data from this RO3 small grants program research will be used to apply for funding through the RO1 mechanism. ..
  24. REGULATION OF BETA-CATENIN NUCLEARIZATION
    CHARLES ETTENSOHN; Fiscal Year: 2006
    ..In addition, using dominant negative constructs and morpholinos, we will examine the developmental function of two regulators of GSK3 activity, disheveled and Akt/PKB. ..
  25. Structure of Circadian Clock Complexes from Cyanobacteria by Three Dimensional EM
    Phoebe L Stewart; Fiscal Year: 2010
    ..abstract_text> ..
  26. Delta and Mesoderm Induction in Eucidaris Embryos
    Hyla Sweet; Fiscal Year: 2004
    ..By focusing on the development of a primitive sea urchin, this research will begin to provide insight on how the Delta/Notch signaling pathway and mesoderm development have evolved within the echinoderm phylum. ..
  27. Acquisition of a Liquid Helium Cryo-Electron Microscope
    PHOEBE STEWART; Fiscal Year: 2003
    ..The financial plan for the long term operation of the microscope includes a significant additional commitment from UCLA for microscope operating expenses. ..

Patents27

  1. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
    Patent Number: JP2016507218-A; Date:2016-03-10
  2. Method of identifying eukaryotic species
    Patent Number: JP2014155500-A; Date:2014-08-28
  3. Yield increase in plants overexpressing the accdp genes
    Patent Number: WO2007011625-A2; Date:2007-01-25
  4. Method of identifying eukaryotic species
    Patent Number: JP2010088398-A; Date:2010-04-22
  5. Sequences of an ih ionic channel and the use thereof
    Patent Number: WO9942574-A1; Date:1999-08-26
  6. KERATIN-BINDING EFFECTOR MOLECULES CONTAINING REACTIVE DYES
    Patent Number: JP2009523706-A; Date:2009-06-25
  7. Method for couplig keratin-binding polypeptides with effector molecules which support carboxylic groups or sulfonic acid groups
    Patent Number: JP2009521404-A; Date:2009-06-04
  8. Method for the production of a keratin-binding effector molecule
    Patent Number: WO2007147445-A; Date:2007-12-27
  9. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  10. Chimeric keratin-binding effector proteins
    Patent Number: JP2009519009-A; Date:2009-05-14
  11. KERATIN-BINDING EFFECTOR MOLECULES, AND METHOD FOR THE PRODUCTION THEREOF
    Patent Number: JP2009517361-A; Date:2009-04-30
  12. Trophoblast cell specific gene manipulation system
    Patent Number: WO2007020786-A; Date:2007-02-22
  13. Sequences of an Ih ion channel and their application
    Patent Number: EP1842917-A1; Date:2007-10-10
  14. Keratin-binding effector molecules containing reactive dyes
    Patent Number: WO2007063024-A2; Date:2007-06-07
  15. Chimeric keratin-binding effector proteins
    Patent Number: WO2007060117-A2; Date:2007-05-31
  16. Selecting and stabilizing dsrna constructs
    Patent Number: WO2007095496-A2; Date:2007-08-23
  17. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  18. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  19. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  20. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  21. Plants with increased yield (lt)
    Patent Number: WO2010034672-A1; Date:2010-04-01
  22. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  23. Plants with increased yield and/or increased tolerance to environmental stress (iy-bm)
    Patent Number: WO2009077611-A2; Date:2009-06-25
  24. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  25. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  26. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance to plant disease
    Patent Number: WO2009027539-A1; Date:2009-03-05
  27. Keratin-binding effector molecules and method for the production thereof by coupling keratin-binding polypeptides with effector molecules which support carboxylic groups or sulfonic acid groups
    Patent Number: WO2007060116-A2; Date:2007-05-31