Genomes and Genes
Alias: bovine, cattle, domestic cattle, domestic cow, Bos taurus, Bos bovis, Bos primigenius taurus, Bos Tauurus, Bovidae sp. Adi Nefas
Publications420 found, 100 shown here
- Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and compositionBernard Grisart
Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 4000 Liege, Belgium
Genome Res 12:222-31. 2002..trait locus (QTL) with a major effect on milk composition--particularly fat content--to the centromeric end of bovine chromosome 14...
- Double muscling in cattle due to mutations in the myostatin geneA C McPherron
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 94:12457-61. 1997..and the identification of mutations in the coding sequence of bovine myostatin in two breeds of double-muscled cattle, Belgian Blue and Piedmontese, which are known to have an increase in muscle mass relative to conventional cattle...
- Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and compositionBernard Grisart
Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 20 Boulevard de Colonster, 4000 Liege Sart Tilman, Belgium
Proc Natl Acad Sci U S A 101:2398-403. 2004..used a positional cloning approach to identify a nonconservative lysine to alanine substitution (K232A) in the bovine DGAT1 gene that was proposed to be the causative quantitative trait nucleotide underlying a quantitative trait ..
- Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2Sebastien Fritz
UNCEIA, Genetics Team, Paris, France
PLoS ONE 8:e65550. 2013..dairy cattle breeds by identifying frequent haplotypes (>1%) showing a deficit in homozygotes among Illumina Bovine 50k Beadchip haplotyping data from the French genomic selection database (47,878 Holstein, 16,833 Montbéliarde, ..
- Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cowsJohn B Cole
Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA
BMC Genomics 12:408. 2011..Here, we report results of a genome-wide analysis of predicted transmitting ability (PTA) of 31 production, health, reproduction and body conformation traits in contemporary Holstein cows...
- Identification of a nonsense mutation in CWC15 associated with decreased reproductive efficiency in Jersey cattleTad S Sonstegard
Bovine Functional Genomics, United States Department of Agriculture, Agricultural Research Service, Beltsville, Maryland, USA
PLoS ONE 8:e54872. 2013..This search led to the discovery of a putative recessive lethal in Jersey cattle on Bos taurus autosome 15...
- Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat contentAndreas Winter
Lehrstuhl für Tierzucht der Technischen Universität München, 85350 Freising Weihenstephan, Germany
Proc Natl Acad Sci U S A 99:9300-5. 2002..Our mapping studies placed DGAT1 close to the region of a quantitative trait locus (QTL) on bovine chromosome 14 for variation in fat content of milk...
- L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthroughYoshihide Yamaguchi
Department of Molecular Neurobiology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
J Biol Chem 287:17765-76. 2012..Since this is the first finding of stop codon readthrough in a common mammalian protein, detailed analysis of L-MPZ expression will help to understand the mechanism of stop codon readthrough in mammals...
- Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)M Amano
Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 01
J Biol Chem 271:20246-9. 1996..The activated Rho-kinase subsequently phosphorylates MLC. This may partly account for the mechanism by which Rho regulates cytokinesis, cell motility, or smooth muscle contraction...
- ZNF280BY and ZNF280AY: autosome derived Y-chromosome gene families in BovidaeYang Yang
Department of Dairy and Animal Science, The Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
BMC Genomics 12:13. 2011..These transpositions are lineage-dependent. The purpose of this study is to investigate the lineage-specific Y-chromosome genes in bovid...
- Bovine prion protein gene (PRNP) promoter polymorphisms modulate PRNP expression and may be responsible for differences in bovine spongiform encephalopathy susceptibilityPetra Sander
Institute for Animal Breeding and Genetics, University of Veterinary Medicine, Hannover, Germany
J Biol Chem 280:37408-14. 2005..However, the known coding polymorphisms within the bovine PRNP gene have little or no effect on bovine spongiform encephalopathy (BSE) susceptibility in cattle...
- A bovine homologue of the human TSPY geneS Jakubiczka
Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
Genomics 17:732-5. 1993We have isolated a male-specific bovine genomic homologue of the human TSPY gene (testis-specific protein, Y-encoded). Two specific transcripts can be detected in bovine testicular RNA...
- A splice site variant in the bovine RNF11 gene compromises growth and regulation of the inflammatory responseArnaud Sartelet
Unit of Animal Genomics, GIGA R, Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
PLoS Genet 8:e1002581. 2012..mapping of a locus on bovine chromosome 3 that underlies a Mendelian form of stunted growth in Belgian Blue Cattle (BBC)...
- Assessment of positional candidate genes myf5 and igf1 for growth on bovine chromosome 5 in commercial lines of Bos taurusC Li
Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
J Anim Sci 82:1-7. 2004..BWT), preweaning average daily gain (PWADG), and average daily gain on feed (ADGF) in commercial lines of Bos taurus. The QTL regions for the growth traits identified using a haplotype association analysis, which included the ..
- Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udderWei Yang
Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
Mol Immunol 45:1385-97. 2008..We examined here, if inadequate activation of the bovine TLR2 and TLR4 pathogen receptors by ligands derived from S...
- Programmed translational readthrough generates antiangiogenic VEGF-AxSandeepa M Eswarappa
Department of Cellular and Molecular Medicine, The Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Cell 157:1605-18. 2014..Furthermore, genome-wide analysis revealed AGO1 and MTCH2 as authentic readthrough targets. Overall, our studies reveal a novel protein-regulated PTR event in a vertebrate system. ..
- NMR structure of the bovine prion proteinF López García
Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule, Honggerberg, CH 8093 Zurich, Switzerland
Proc Natl Acad Sci U S A 97:8334-9. 2000..of electrostatic charges, which then appears to be the principal structural feature of the "healthy" PrP form that might affect the stringency of the species barrier for transmission of prion diseases between humans and cattle.
- Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattleR Kambadur
AgResearch, Ruakura, Hamilton, New Zealand
Genome Res 7:910-6. 1997..mh), commonly known as double muscling, occurs with high frequency in the Belgian Blue and Piedmontese cattle breeds...
- Identification and characterization of the bovine G protein-coupled receptor GPR41 and GPR43 genesA Wang
Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
J Dairy Sci 92:2696-705. 2009..In this study, we determined first, whether the bovine genome contains genes similar to the human GPR41 and GPR43 genes; second, whether and where these genes are ..
- Genetic heterogeneity at the bovine KIT gene in cattle breeds carrying different putative alleles at the spotting locusL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
Anim Genet 41:295-303. 2010..The S locus was mapped on bovine chromosome 6 in the region containing the KIT gene...
- Identification of splice variants, targeted microRNAs and functional single nucleotide polymorphisms of the BOLA-DQA2 gene in dairy cattleQinlei Hou
Laboratory of Molecular Genetics and Breeding, Center of Dairy Cattle Research, Shandong Academy of Agricultural Sciences, Jinan, China
DNA Cell Biol 31:739-44. 2012Major histocompatibility complex, class II, DQ alpha 2, also named BOLA-DQA2, belongs to the Bovine Leukocyte Antigen (BOLA) class II genes which are involved in the immune response...
- Allelic heterogeneity of Crooked Tail Syndrome: result of balancing selection?A Sartelet
Unit of Animal Genomics, GIGA R and Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium
Anim Genet 43:604-7. 2012..1906T>C) in the bovine MRC2 gene causing the Crooked Tail Syndrome in Belgian Blue Cattle. We demonstrate that the ensuing substitution of the highly conserved Cysteine 636 with Arginine causes ..
- Modulation of the oligomerization state of the bovine F1-ATPase inhibitor protein, IF1, by pHE Cabezon
Medical Research Council Dunn Human Nutrition Unit, Cambridge, United Kingdom
J Biol Chem 275:25460-4. 2000b>Bovine IF(1), a basic protein of 84 amino acids, is involved in the regulation of the catalytic activity of the F(1) domain of ATP synthase. At pH 6.5, but not at basic pH values, it inhibits the ATP hydrolase activity of the enzyme...
- Crystal structure of rhodopsin: A G protein-coupled receptorK Palczewski
Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
Science 289:739-45. 2000..Identification of a set of residues that mediate interactions between the transmembrane helices and the cytoplasmic surface, where G-protein activation occurs, also suggests a possible structural change upon photoactivation...
- Copy number variation of testis-specific protein, Y-encoded (TSPY) in 14 different breeds of cattle (Bos taurus)C K Hamilton
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
Sex Dev 3:205-13. 2009..Previous studies have estimated that TSPY ranges from 50-200 copies in cattle. To examine TSPY localization on the Y chromosome we employed fluorescence in situ hybridization (FISH) and fiber-..
- Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?Frank Gillardon
Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Str 65, 88397 Biberach an der Riss, Germany
J Neurochem 110:1514-22. 2009..Here we show that recombinant human LRRK2 preferentially phosphorylates tubulin-beta purified from bovine brain and that phosphorylation is three-fold enhanced by the LRRK2(G2019S) mutation...
- Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 diseaseNatalia Friedland
Center for Advanced Biotechnology and Medicine, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
Proc Natl Acad Sci U S A 100:2512-7. 2003..NPC2 has an Ig-like fold stabilized by three disulfide bonds. The structure of the bovine protein reveals a loosely packed region penetrating from the surface into the hydrophobic core that forms adjacent ..
- Mapping of a milk production quantitative trait locus to a 420-kb region on bovine chromosome 6Hanne Gro Olsen
Department of Animal and Aquacultural Sciences, Agricultural University of Norway, N 1432 Aas, Norway
Genetics 169:275-83. 2005..5 cM on chromosome 6 in Norwegian dairy cattle. This article aimed to refine this position by increasing the map density in the region by a set of single-..
- DGAT1 underlies large genetic variation in milk-fat composition of dairy cowsA Schennink
Animal Breeding and Genomics Centre, Wageningen University, 6700 AH Wageningen, The Netherlands
Anim Genet 38:467-73. 2007..001). We conclude that selective breeding can make a significant contribution to change the fat composition of cow's milk.
- Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free stateT Tanaka
Division of Molecular and Structural Biology, Ontario Cancer Institute, Toronto, Canada
Nature 376:444-7. 1995..The myristoyl group is sequestered in a deep hydrophobic pocket formed by many aromatic and other hydrophobic residues from five flanking helices...
- Domain structure of a mammalian myosin I betaO Reizes
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas 75235
Proc Natl Acad Sci U S A 91:6349-53. 1994We have determined the primary structure of a myosin I (called mammalian myosin I beta, MMI beta) from bovine brain and identified its functional domains. The protein was previously purified from brain and adrenal gland...
- Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysisAnne S Meyer
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Cell 113:369-81. 2003..Understanding the distinct mechanisms governing eukaryotic and bacterial chaperonin function may reveal how TRiC has evolved to fold specific eukaryotic proteins...
- A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformationBo Thomsen
Department of Genetics and Biotechnology, Danish Institute of Agricultural Sciences, DK 8830 Tjele, Denmark
Genome Res 16:97-105. 2006The extensive use of a limited number of elite bulls in cattle breeding can lead to rapid spread of recessively inherited disorders...
- Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81Changlu Liu
Johnson and Johnson Pharmaceutical Research and Development LLC, San Diego, CA 92121, USA
J Biol Chem 284:2811-22. 2009..Our results indicate that lactate suppresses lipolysis in adipose tissue through a direct activation of GPR81. GPR81 may thus be an attractive target for the treatment of dyslipidemia and other metabolic disorders...
- Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH bindingG Zhou
Skirball Institute of Biomolecular Medicine, Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Cell Sci 114:4095-103. 2001..coli, and that the binding of uropathogenic bacteria to uroplakin Ia may play a key role in mediating the urothelial responses to bacterial attachment...
- Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate proteinK M Flaherty
Beckman Laboratories for Structural Biology, Department of Cell Biology, Stanford University School of Medicine, California 94305 5400
Nature 346:623-8. 1990The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A...
- Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteinsJ Yu
Ronald O Perelman Department of Dermatology, New York University Medical School, New York 10016
J Cell Biol 125:171-82. 1994..indicate that the outer leaflet of AUM is composed of crystalline patches of 12-nm protein particles, and that bovine AUMs contain three major proteins: the 27- to 28-kD uroplakin I, the 15-kD uroplakin II and the 47-kD uroplakin ..
- Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoproteinX R Wu
Ronald O Perelman Department of Dermatology, New York University School of Medicine, NY 10016
J Cell Sci 106:31-43. 1993..The fact that of the three major proteins of AUM only UPIII has a significant cytoplasmic domain suggests that this molecule may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells...
- Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattleT Goldammer
Molecular Biology Research Division, Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
Clin Diagn Lab Immunol 11:174-85. 2004..the impact of this system on the counteraction of infections of the mammary gland (mastitis), we characterized the bovine gene encoding the key PRR Toll-like receptor 9 (TLR9) and mapped its precise position on chromosome BTA22...
- Hydrogen peroxide is the major oxidant product of xanthine oxidaseEric E Kelley
Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Free Radic Biol Med 48:493-8. 2010..Furthermore, XO bound to glycosaminoglycans on the apical surface of bovine aortic endothelial cells demonstrated a similar ROS production profile...
- An unusual splice defect in the mitofusin 2 gene (MFN2) is associated with degenerative axonopathy in Tyrolean Grey cattleCord Drogemuller
Institute of Genetics, University of Bern, Bern, Switzerland
PLoS ONE 6:e18931. 2011Tyrolean Grey cattle represent a local breed with a population size of ∼5000 registered cows. In 2003, a previously unknown neurological disorder was recognized in Tyrolean Grey cattle...
- Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransductionW A Gorczyca
Department of Ophthalmology, University of Washington, Seattle 98195
J Biol Chem 270:22029-36. 1995....
- Identification of core amino acids stabilizing rhodopsinA J Rader
Center for Computational Biology and Bioinformatics, Department of Molecular Biology and Biochemistry, School of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
Proc Natl Acad Sci U S A 101:7246-51. 2004..The observed high degree of conservation (78.9%) of this disulfide bond across all GPCR classes suggests that it is critical for the stability and function of GPCRs...
- Highly effective SNP-based association mapping and management of recessive defects in livestockCarole Charlier
Unit of Animal Genomics, GIGA Research and Department of Animal Sciences, Faculty of Veterinary Medicine, University of Liège B34, 1 Avenue de l Hopital, 4000 Liege, Belgium
Nat Genet 40:449-54. 2008..We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle ..
- Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomesAnne Sophie Van Laere
Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liege, Belgium
Genome Res 18:1884-95. 2008..Accordingly, we demonstrate that cattle share their PAB with all other examined ruminants including sheep, but not with cetaceans or more distantly ..
- Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence inductionJoo Yeun Oh
Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Biomedical Research Building II, 901 19th Street South, Birmingham, AL 35294 0022, USA
Biochem J 411:297-306. 2008....
- Regulation of apoptosis in the bovine blastocyst by insulin and the insulin-like growth factor (IGF) superfamilyA T Byrne
Department of Biology, University of York, York, United Kingdom
Mol Reprod Dev 62:489-95. 2002..We have previously shown that apoptosis occurs in the preimplantation bovine embryo and is influenced by in vitro culture conditions...
- Bulldog dwarfism in Dexter cattle is caused by mutations in ACANJulie A L Cavanagh
Reprogen, The University of Sydney, PMB3, Camden, New South Wales 2570, Australia
Mamm Genome 18:808-14. 2007Bulldog dwarfism in Dexter cattle is one of the earliest single-locus disorders described in animals. Affected fetuses display extreme disproportionate dwarfism, reflecting abnormal cartilage development (chondrodysplasia)...
- Evidence that polymorphonuclear neutrophils infiltrate into the developing corpus luteum and promote angiogenesis with interleukin-8 in the cowSineenard Jiemtaweeboon
Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080 8555, Japan
Reprod Biol Endocrinol 9:79. 2011After ovulation in the cow, the corpus luteum (CL) rapidly develops within a few days with angiogenesis and progesterone production. CL formation resembles an inflammatory response due to the influx of immune cells...
- Transcriptional regulation of lipid synthesis in bovine mammary epithelial cells by sterol regulatory element binding protein-1L Ma
Department of Dairy Science, Virginia Tech, Blacksburg 24061, USA
J Dairy Sci 95:3743-55. 2012..the transcriptional regulation of lipid synthesis by sterol regulatory element binding protein-1 (SREBP-1) in bovine mammary epithelial cells...
- The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilageP J Neame
Shriners Hospital for Crippled Children, Tampa, Florida 33612
J Biol Chem 269:21547-54. 1994..Based on anchored polymerase chain reaction analysis of the mRNA, there is some minor heterogeneity in the position of the 5' end of the message...
- Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cellsM Osawa
Department of Structural Analysis, National Cardiovascular Center Research Institute, Osaka Japan
Eur J Cell Biol 72:229-37. 1997..We have recently reported that a glycoprotein is rapidly tyrosine-phosphorylated in bovine ECs exposed to fluid flow or osmotic shock. Here were cloned a 3...
- TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow?T G Berryere
Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Anim Genet 34:169-75. 2003..The complete coding sequence of bovine TYRP1 was determined from cDNA derived from skin biopsies of cattle with various colours...
- Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1Chandreyee Das
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2280, USA
Virology 318:306-17. 2004..In the related bovine immunodeficiency virus (BIV), Tat recognizes its cognate TAR element with high affinity and specificity in the ..
- p66shc, but not p53, is involved in early arrest of in vitro-produced bovine embryosL A Favetta
Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
Mol Hum Reprod 10:383-92. 2004High embryo loss occurs in the first week of bovine embryo development, with a high percentage of embryonic arrest...
- Radiation hybrid mapping of all 10 characterized bovine Toll-like receptorsK McGuire
Division of Genetics and Genomics, Roslin Institute, Roslin, Midlothian, Edinburgh EH25 9PS, UK
Anim Genet 37:47-50. 2006..TLR1, TLR6 and TLR10 map closely together on Bos taurus chromosome 6 (BTA6), while TLR7 and TLR8 map to the X chromosome...
- The insertion of a full-length Bos taurus LINE element is responsible for a transcriptional deregulation of the Normande Agouti geneMichael Girardot
Unité de Génétique Moléculaire Animale, UMR 1061 INRA Université de Limoges, Limoges, France
Pigment Cell Res 19:346-55. 2006..The Normande cattle have a characteristic coat color phenotype with a variable presence of black (eumelanin) hair over a red/brown ..
- Cardiac high molecular weight calmodulin-binding protein is homologous to calpastatin I and calpastatin IINisha Singh
Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, 103 Hospital Drive, Saskatoon, Saskatchewan, Canada S7N 0W8
Biochem Biophys Res Commun 373:387-91. 2008..In addition, HMWCaMBP also showed the same affinities for m-calpain as calpastatin I and calpastatin II. Our findings suggest that HMWCaMBP is the homolog of calpastatin and may be a CaM-binding form of calpastatin...
- The acute-phase protein serum amyloid A3 is expressed in the bovine mammary gland and plays a role in host defenceAdrian J Molenaar
Dairy Science and Technology, Ruakura Research Centre, Hamilton, New Zealand
Biomarkers 14:26-37. 2009..The M-SAA3 mRNA was localized to restricted populations of bovine mammary epithelial cells (MECs)...
- Up-regulation of expression of interferon-stimulated gene 15 in the bovine corpus luteum during early pregnancyL Yang
College of Animal Science and State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China
J Dairy Sci 93:1000-11. 2010..in ovine CL is speculated to be through an endocrine pathway, but it is unclear whether expression of ISG15 in bovine CL is via such a pathway...
- A deletion mutation in bovine SLC4A2 is associated with osteopetrosis in Red Angus cattleStacey N Meyers
Laboratory of Molecular Genetics, Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
BMC Genomics 11:337. 2010..In cattle, osteopetrosis can either be induced during gestation by viral infection of the dam, or inherited as a recessive ..
- Gene expression of tumour necrosis factor and insulin signalling-related factors in subcutaneous adipose tissue during the dry period and in early lactation in dairy cowsH Sadri
Veterinary Physiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
J Anim Physiol Anim Nutr (Berl) 94:e194-202. 2010..Alternatively, it may indicate that post-transcriptional modifications of these factors came into play and may have concealed an involvement...
- Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockadeRyoyo Ikebuchi
Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 060 0818, Japan
Vet Res 42:103. 2011..role of PD-L1 in BLV infection, we identified the bovine PD-L1 gene, and examined PD-L1 expression in BLV-infected cattle in comparison with uninfected cattle...
- Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localizationElke Albrecht
Research Unit Muscle Biology and Growth, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
PLoS ONE 7:e35282. 2012..study was to characterize the mRNA expression of different ASIP transcripts and of putative targets in different bovine tissues, as well as to study consequences on protein abundance and localization...
- Adipose tissue angiopoietin-like protein 4 messenger RNA changes with altered energy balance in lactating Holstein cowsD A Koltes
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
Domest Anim Endocrinol 43:307-16. 2012..The consistency and magnitude of the increase in ANGPTL4 mRNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow.
- Adiponectin deficit during the precarious glucose economy of early lactation in dairy cowsSarah L Giesy
Department of Animal Science, Ithaca, NY 14853, USA
Endocrinology 153:5834-44. 2012..These data suggest that reduced plasma adiponectin belongs to the subset of hormonal adaptations in EL dairy cows facilitating mammary glucose uptake via promotion of insulin resistance...
- Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesisLi Min Lu
Key Laboratory of Dairy Science of Education Ministry, Northeast Agricultural University, Harbin 150030, Heilongjiang, China
Molecules 18:263-75. 2012..proteomic technology was used to identify phosphoproteins responsible for milk protein synthesis in dairy cow mammary epithelial cells (DCMECs)...
- SOCS3-mediated blockade reveals major contribution of JAK2/STAT5 signaling pathway to lactation and proliferation of dairy cow mammary epithelial cells in vitroYu Ling Huang
Key Laboratory of Dairy Science of Education Ministry, Northeast Agricultural University, Harbin 150030, Heilongjiang, China
Molecules 18:12987-3002. 2013..Here, we used dairy cow mammary epithelial cells (DCMECs) to analyze the function of SOCS3 and the interaction between SOCS3 and STAT5a...
- Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionM Uehata
Discovery Research Tokyo, Yoshitomi Pharmaceutical Industries Ltd, Saitama, Japan
Nature 389:990-4. 1997..Our findings indicate that p160ROCK-mediated Ca2+ sensitization is involved in the pathophysiology of hypertension and suggest that compounds that inhibit this process might be useful therapeutically...
- Short communication: Effects of the progesterone receptor variants on fertility traits in cattleA M Driver
Department of Dairy Science, University of Wisconsin Madison, Madison, WI 53706, USA
J Dairy Sci 92:4082-5. 2009..Currently, it is unknown what variants of the PGR gene are related to fertility traits in cattle. Identification of such variants would allow the implementation of marker-assisted selection in breeding schemes...
- Calpain 1-titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibrilFabrice Raynaud
Cell Motility Laboratory, EPHE, UMR 5539, UM2, Montpellier, France
FEBS J 272:2578-90. 2005..Furthermore, calpain 1 is found to localize in myofibril fractures, described as proteolysis sites, in postmortem bovine skeletal red muscles, near the calcium deposits located at the N1 and N2 level...
- Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattleD E Shuster
U S Department of Agriculture, Agricultural Research Service, Ames, IA
Proc Natl Acad Sci U S A 89:9225-9. 1992Two point mutations were identified within the gene encoding bovine CD18 in a Holstein calf afflicted with leukocyte adhesion deficiency (LAD)...
- Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophilsM E Selsted
Department of Pathology, College of Medicine, University of California, Irvine 92717
J Biol Chem 268:6641-8. 1993A new family of cysteine-rich antimicrobial peptides from bovine neutrophils was isolated and characterized...
- Complete genomic sequence of the bovine prion gene (PRNP) and polymorphism in its promoter regionD Hills
Division of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
Anim Genet 32:231-2. 2001
- Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunitJie Zheng
Howard Hughes Medical Institute, Seattle, WA 98195, USA
Neuron 36:891-6. 2002..We find, surprisingly, that the channel contains three CNGA1 subunits and only one CNGB1 subunit. These results have implications for CNG channel function in particular and assembly of membrane proteins in general...
- Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1Jun Cai
School of Optometry and Vision Sciences, Cardiff University, UK
J Biol Chem 281:3604-13. 2006..This confirms the importance of PEDF and VEGFR-1 in the negative regulation of angiogenesis...
- Cloning of the bovine prion-like Shadoo (SPRN) gene by comparative analysis of the predicted genomic locusCristina Uboldi
Department of Genetics and Microbiology A Buzzati Traverso, University of Pavia, Pavia, Italy
Mamm Genome 17:1130-9. 2006..We mapped SPRN in Bos taurus by comparative analysis of the locus and of the predicted flanking genes...
- Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPKPeter F Mount
Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia
Atherosclerosis 200:28-36. 2008..test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid oxidation in endothelium, stimulations of bovine aortic endothelial cells (BAECs) with bradykinin were performed. BK stimulation caused a 2...
- Polymorphism in genes of growth hormone receptor (GHR) and insulin-like growth factor-1 (IGF1) and its association with both the IGF1 expression in liver and its level in blood in Polish Holstein-Friesian cattleAndrzej Maj
Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05 552 Wolka Kosowska, Poland
Neuro Endocrinol Lett 29:981-9. 2008Polymorphisms in the bovine ghr and igf1 genes. Ghr and igf1 genes have been associated with milk and meat production of cattle. However, the molecular and physiological mechanisms underlying such associations are unknown...
- A small set of extra-embryonic genes defines a new landmark for bovine embryo stagingSéverine A Degrelle
INRA ENVA, UMR 1198 Biologie du Developpement et Reproduction, Domaine de Vilvert, Jouy en Josas, France
Reproduction 141:79-89. 2011..To this end, we have profiled bovine extra-embryonic tissues at peri-implantation stages, when gastrulation and early neurulation occur, and analysed ..
- Ionotropic glutamate receptor AMPA 1 is associated with ovulation rateMayumi Sugimoto
National Livestock Breeding Center, Nishigo, Japan
PLoS ONE 5:e13817. 2010..Based on a genome-wide association study in Bos taurus, we found that ovulation rate is influenced by a variation in the N-terminal leucine/isoleucine/valine-binding ..
- Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cellsShuzhen Liu
University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Mol Immunol 48:895-908. 2011..in MEC the role of NF-κB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle. Abrogating NF-κB binding to that site by introduction of a single point mutation blocks promoter activity of ..
- Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattleBrian W Brunelle
Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, IA 50010 USA
BMC Vet Res 4:36. 2008..These factors have been extensively studied in breeds of Bos taurus cattle in relation to classical bovine spongiform encephalopathy (BSE)...
- Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrilsTamotsu Zako
Bioengineering Laboratory, RIKEN Institute, Saitama, Japan
Biophys J 96:3331-40. 2009..We demonstrate here that bovine insulin forms flexible filaments in the presence of a reducing agent, Tris (2-carboxyethyl) phosphine...
- Indels within promoter and intron 1 of bovine prion protein gene modulate the gene expression levels in the medulla oblongata of two Japanese cattle breedsG Msalya
Kagoshima University, Japan
Anim Genet 41:218-21. 2010..In cattle, however, none of the known coding polymorphisms has a direct effect on bovine spongiform encephalopathy (BSE)...
- Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channelU B Kaupp
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
Nature 342:762-6. 1989The complete amino-acid sequence of the cyclic GMP-gated channel from bovine retinal rod photoreceptors, deduced by cloning and sequencing its complementary DNA, shows that the protein contains several putative transmembrane segments, ..
- How the regulatory protein, IF(1), inhibits F(1)-ATPase from bovine mitochondriaJonathan R Gledhill
Medical Research Council Dunn Human Nutrition Unit, Cambridge CB2 0XY, United Kingdom
Proc Natl Acad Sci U S A 104:15671-6. 2007The structure of bovine F(1)-ATPase inhibited by a monomeric form of the inhibitor protein, IF(1), known as I1-60His, lacking most of the dimerization region, has been determined at 2.1-A resolution...
- Novel mutations of the FASN gene and their effect on fatty acid composition in Japanese Black beefTsuyoshi Abe
National Livestock Breeding Center, 1 Odakurahara, Nishigo, Fukushima, Japan
Biochem Genet 47:397-411. 2009..coding sequence of the bovine fatty acid synthase (FASN) gene of an F2 population from Japanese Black and Limousin cattle. Two mutations, g.16024A>G and g...
- Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattleJyothsna Tejomurtula
Division of Animal and Nutritional Sciences, Laboratory of Animal Biotechnology and Genomics, West Virginia University, Morgantown, West Virginia 26506, USA
Biol Reprod 81:333-42. 2009..Through analysis of expressed sequence tags from a bovine oocyte cDNA library, we identified a new member of the importin alpha family (named importin alpha8)...
- Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcriptsU Wissenbach
Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, Homburg Saar, Germany
FEBS Lett 429:61-6. 1998..Complementary DNA was isolated from a bovine testis cDNA library which encodes bovine trp2 (btrp2), a protein of 432 amino acid residues comprising four ..
- Organization and concerted evolution of the ampliconic Y-chromosomal TSPY genes from cattleEdward L C Verkaar
Faculty of Veterinary Medicine, Yalelaan 1, 3584 CL Utrecht, The Netherlands
Genomics 84:468-74. 2004..Analysis of bovine BAC clones leads to an estimate of 90 TSPY loci on the bovine Y chromosome...
- Genomic structure and transcript variants of the bovine DAZL geneW S Liu
Department of Animal Biotechnology, College of Agriculture, Biotechnology and Natural Resources, University of Nevada, Reno, NV 89557, USA
Cytogenet Genome Res 116:65-71. 2007..In the present study, we have cloned and characterized the bovine DAZL (bDAZL) gene...
- Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 diseaseSujuan Xu
Center for Advanced Biotechnology and Medicine, Department of Biochemistry, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
J Biol Chem 282:23525-31. 2007..Here we report the crystal structure of bovine NPC2 bound to cholesterol-3-O-sulfate, an analog that binds with greater apparent affinity than cholesterol...
- AluI polymorphism of the bovine growth hormone (GH) gene, resumption of ovarian cyclicity, milk production and loss of body condition at the onset of lactation in dairy cowsO Balogh
Faculty of Veterinary Science, Szent Istvan University, 1078 Budapest István u 2, Hungary
Theriogenology 71:553-9. 2009..We concluded that, under field conditions, AluI polymorphism of the bovine GH gene had no effect on the interval from calving to first ovulation and could not be directly related to ..
- Molecular characterization of the DDX3Y gene and its homologs in cattleW S Liu
Department of Dairy and Animal Science, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Cytogenet Genome Res 126:318-28. 2009..Here, we report the characterization of the bovine (b) DDX3Y gene and its homologs DDX3X and PL10...
- Effect of VEGF (vascular endothelial growth factor) on expression of IL-8 (interleukin-8), IL-1beta and their receptors in bovine theca cellsChiaki Murayama
Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
Cell Biol Int 34:531-6. 2010..receptors, CXCR1 and IL-1R1 in the theca cells of PRF (preselection) and POF (postselection follicles) from the bovine ovary...
- The major protein of bovine seminal plasma, PDC-109, is a molecular chaperoneRajeshwer Singh Sankhala
School of Chemistry, University of Hyderabad, Hyderabad 500046, India
Biochemistry 49:3908-18. 2010The major protein of bovine seminal plasma, PDC-109, binds to choline phospholipids on the sperm plasma membrane and induces the efflux of cholesterol and choline phospholipids, which is an important step in sperm capacitation...
- Interaction of mammalian seminal plasma protein PDC-109 with cholesterol: implications for a putative CRAC domainSilvia Scolari
Department of Biology, Humboldt University Berlin, Invalidenstrasse 42, 10115 Berlin, Germany
Biochemistry 49:9027-31. 2010..To characterize the interaction between the bovine Fn2 protein PDC-109 and cholesterol, we have investigated the effect of PDC-109 on the dynamics of fluorescent ..
- Laminar shear stress up-regulates peroxiredoxins (PRX) in endothelial cells: PRX 1 as a mechanosensitive antioxidantAmy L Mowbray
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
J Biol Chem 283:1622-7. 2008..We hypothesized that PRX are responsible for the anti-oxidative effect of LS. To test this hypothesis, bovine aortic endothelial cells (BAEC) were subjected to LS (15 dyn/cm(2)), OS (+/-5 dyn/cm(2), 1 Hz), or static ..
- A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattleJames E Koltes
Department of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, IA 50011 3150, USA
Proc Natl Acad Sci U S A 106:19250-5. 2009Historically, dwarfism was the major genetic defect in U.S. beef cattle. Aggressive culling and sire testing were used to minimize its prevalence; however, neither of these practices can eliminate a recessive genetic defect...
- Antibodies and Congenital Neospora Caninum TransmissionGARY HALDORSON; Fiscal Year: 2004..Transplacental transmission of neospora caninum results in abortions, stillbirths, and congenital infection in cattle and dogs. This apicomplexan parasite is similar to Toxoplasma gondii and Plasmodium sp...
- S. typhimurium Genes Required for Colonization of CattleHelene Andrews Polymenis; Fiscal Year: 2004..typhimurium variants (phage types DT2 and DT99) that cause fatal pigeon paratyphoid do not persist in cattle. The objective of this proposal is to identify the genes responsible for the epidemiologic success of S...
- Biochemical Detection of Prions in BloodJoaquin Castilla; Fiscal Year: 2005..Although rare diseases, the recent outbreak of Bovine Spongiform Encephalopathy and Chronic Wasting disease and the transmission of the disease from cattle to humans ..
- Claudio Soto; Fiscal Year: 2014..outbreak of Bovine Spongiform Encephalopathy and Chronic Wasting disease and the transmission of the disease from cattle to humans have risen a great public health concern...
- Stephen L Hajduk; Fiscal Year: 2014DESCRIPTION (provided by applicant): Trypanosoma brucei brucei causes Nagana in cattle but is non-infectious to humans because of its susceptibility to the cytotoxic activity of normal human serum...
- Christopher P Jaroniec; Fiscal Year: 2015..a group of fatal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle...
- Novel High Affinity and Long-Acting Bovine FSH Analogs for Veterinary SuperovulatBRUCE DALE WEINTRAUB; Fiscal Year: 2012DESCRIPTION (provided by applicant): Bovine ovarian superovulation is the current state-of-the-art method employed worldwide to maintain and improve milk and beef production through genetic selection of the best quality breeders and best ..
- F Nina Papavasiliou; Fiscal Year: 2014..The parasite Trypanosoma brucei is the causative agent of African sleeping sickness in humans and of Nagana in cattle, and one of the leading impediments to development in much of sub-Saharan Africa. T...
- Mingming Wu; Fiscal Year: 2014..For this project, the bovine model will not only provide useful information to the cattle industry but also to human medicine, because ..
- HEATHER MICHELLE FRITZ; Fiscal Year: 2015..g. swine, cattle, sheep) containing bradyzoite tissue cysts, or through congenital transmission...
- Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigenAna M Espino; Fiscal Year: 2013..hepatica causes liver fluke disease or fascioliasis, thereby affecting the health of humans, as well as sheep, cattle and goats, among others mammalians. Fascioliasis causes losses in agriculture estimated at >US3...
- Pablo Juan Ross; Fiscal Year: 2016..Early embryonic mortality is a major cause of infertility in dairy cattle and humans. In bovine embryos, methylation of histone H3 lysine 27 is one of the epigenetic marks that are dynamically remodeled...
- Christina Sigurdson; Fiscal Year: 2016..Zoonotic prion transmission is of concern, as the bovine spongiform encephalopathy (BSE) epidemic has led to nearly 200 cases of prion infection in humans...
- Se Jin Lee; Fiscal Year: 2014..Subsequent genetic studies in cattle, sheep, dogs, and humans have all shown that the function of myostatin as a negative regulator of muscle mass has ..
- Mark D Zabel; Fiscal Year: 2016..spongiform encephalopathies (TSEs) include scrapie in sheep;bovine spongiform encephalopathy (BSE) in cattle;chronic wasting disease (CWD) in deer and elk;and Kuru and Creutzfeldt-Jakob disease in humans...
- Vanessa Sperandio; Fiscal Year: 2016..The main reservoir for EHEC is cattle herds...
- Adam Zlotnick; Fiscal Year: 2014..BEV is non-pathogenic even in cattle, where it is endemic...
- Bibo Li; Fiscal Year: 2016..applicant): Trypanosoma brucei is a protozoan parasite that causes African trypanosomiasis in humans and nagana in cattle. In mammalian hosts, bloodstream form (BF) T...
- Artiodactyl Gene Modification with Tal Effector NucleasesSCOTT CHRISTOPHER FAHRENKRUG; Fiscal Year: 2012..studies proposed here will establish a new paradigm for the genetic modification of artiodactyls (pigs, sheep, and cattle) for use as large animal models of human disease and the production of biomedical materials...
- Claudio Soto; Fiscal Year: 2016..Although rare, the recent outbreak of Bovine Spongiform Encephalopathy(BSE) in cattle and Chronic Wasting disease (CWD) in cervids and the transmission of the ..
- Investigation of Occupational Exposure to and Infection by MRSA in Rural IowaTara Smith; Fiscal Year: 2012..We will examine 30 farms during this research, including farms with live swine, cattle, and poultry. In the second part of our research plan, we will examine transmission of S...
- Evidence based control strategies of Sleeping Sickness vectorsSerap Aksoy; Fiscal Year: 2012..is at risk of HAT outbreaks due to ongoing epidemics in neighboring Uganda and increased movement of people and cattle (known reservoirs for Trypanosoma brucei rhodesiense)...
- Structure and assembly of the fungal prion HET-sWilliam N Wan; Fiscal Year: 2013..TSEs include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer and elk, and several forms of ..
- Lisa Murphy; Fiscal Year: 2016..If the Charm ROSA-M readers can be validated for the analysis of dog food, cattle feed, and swine feed, they will provide an easy method for minimally-trained personnel at multiple laboratories to ..
- Claudio Soto; Fiscal Year: 2014..sCJD), the most common form, and variant CJD (vCJD) which is associated to consumption of cattle meat infected by bovine spongiform encephalopathy...
- James D Bangs; Fiscal Year: 2015..are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness), as well as nagana in cattle and other livestock...
- GREGORY CHARLES GRAY; Fiscal Year: 2016..Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle. Large segments of the normally nomadic pastoral populations have begun migrating to urban areas and introducing ..
- Julia K Gilden; Fiscal Year: 2015..protozoa responsible for causing human African trypanosomiasis (HAT, sleeping sickness) in humans and nagana in cattle and other livestock...
- Peng George Wang; Fiscal Year: 2016..coli fermentation. Such a bioconjugate already offers good possibility to be used to induce antibodies in cows or cattle to kill an inoculum of E. coli O157, since the vaccines can be produced in large scale economically...
- High Throughput Screening for Foot and Mouth Disease Virus AntiviralsJohn F Atkins; Fiscal Year: 2013DESCRIPTION (provided by applicant): The infection of cattle with Foot and Mouth Disease Virus (FMDV) causes not only great economic damage but great popular panic, e.g...
- LINDA HICKAM; Fiscal Year: 2014..Missouri's agricultural diversity includes 107,825 farms, 3 million swine, over 3 million cattle, 4,448 egg retailers, 764 egg dealers, 8 processors, as well as 1,445 total permitted and licensed dairy farms, ..
- Julia F Charles; Fiscal Year: 2015..A recent publication has identified a nearly identical phenotype in cattle that lack SLC4A2...
- Key molecular mechanisms of extraneural pathogenesis and transmission of TSEsMark D Zabel; Fiscal Year: 2012..include chronic wating disease (CWD) of deer and elk, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jacob disease and kuru in humans...
- Thomas E Spencer; Fiscal Year: 2016..endometrial receptivity an pregnancy success, which will increase production efficiency and profitability of cattle enterprises...
- The development of a recombinant vaccine against human onchocerciasisSara Lustigman; Fiscal Year: 2013..Importantly, protective immunity against Ov larvae has now been definitively demonstrated in humans, cattle and mice, thereby proving the conceptual underpinnings that a vaccine can be produced against this infection...
- Shinji Makino; Fiscal Year: 2014..disease of sub-Saharan Africa that can emerge in explosive mosquito-borne epidemics, decimating herds of sheep and cattle and resulting in enormous economic losses;humans are infected concurrently, and their infection results in ..
- Kirk E Smith; Fiscal Year: 2014..specific questions about well water and other exposures), and application of GIS using data sources such as cattle density, geologic sensitivity to groundwater contamination, and climate variables (e.g., flooding)...
- Philip C Hopewell; Fiscal Year: 2014..livestock keepers (pastoralists) combined with poor public health infrastructure, limited TB control measures for cattle and animal products, and a large immunocompromised human population due to HIV/AIDS, make Africa particularly ..
- Robert Sheridan; Fiscal Year: 2014..If funded we propose to expand the inspection and surveillance testing of cattle feeds and feed ingredients manufactured and distributed in NY State...
- CLAUDIA G COLES; Fiscal Year: 2014..WSDA describes Washington State's vulnerability to BSE agent release from imported Canadian cattle in age cohorts shared by the ongoing BSE positives identified by Canadian BSE surveillance...
- EVC2: A novel modulator in tooth developmentYoshiyuki Mochida; Fiscal Year: 2013..A causative gene, LIMBIN for bovine chondrodysplastic dwarfism (bcd) found in Japanese brown cattle was later identified as the bovine ortholog of EVC2, indicating the significance of EVC2 protein function...
- Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrheaLinda J Saif; Fiscal Year: 2010..The foreign collaborator will produce the Abs (llama VHH, chicken egg IgY, bovine IgG) and conduct the calf experiments. Students from INTA will be trained in Dr...
- LYMPHOCYTE-MEDIATED IMMUNITY TO ANAPLASMA MARGINALEReginald Valdez; Fiscal Year: 1999..There was some uncertainty as to the extent of the problem of acute anaplasmosis infection in cattle and how the research findings might impact the field. Since Dr...
- MARKERS OF HUMAN INFECTION WITH BOVINE LEUKEMIA VIRUSGERTRUDE BUEHRING; Fiscal Year: 2007..Bovine leukemia virus (BLV), an oncogenic retrovirus, causes widespread infection of cattle globally...
- Characterization of de novo generation of infectious prionsJoaquin Castilla; Fiscal Year: 2009..The occurrence of spontaneous cases of prion diseases in humans (sporadic CJD) and in other species, i.e. Bovine spongiform encephalopathy (BSE) in US cattle and Nor98 (atypical scrapie) in New Zealand sheep, provide evidence ..
- Preventing Human Prion Diseases - Inactivation of PrionsStanley B Prusiner; Fiscal Year: 2010..plan to study three strains of prions passaged in mice: RML and 301V, which originated from sheep with scrapie and cattle with BSE, respectively, plus a novel synthetic strain MoSP1, which is the most stable strain reported to date...
- 2009 Spirochetes, Biology ofDavid A Haake; Fiscal Year: 2010..including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been very difficult to study...
- Immunogenicity of the Type IV Secretin SystemWENDY CATHERINE BROWN; Fiscal Year: 2012..By testing cattle that express a diverse repertoire of class II haplotypes, representative of the diversity of MHC class II ..
- REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEIChing Wang; Fiscal Year: 2009..are the causative pathogens of spp., African sleeping sickness in humans and nagana in cattle. They are a family of sickness in humans and nagana in cattle...
- Structural basis of species-specific infectivities of two prion strainsPeter M Tessier; Fiscal Year: 2010..infectious proteins that cause devastating neurodegenerative diseases (transmissible encephalopathies) in humans, cattle and other mammals...
- Assessing the Transmissibility of CWD to HumansQingzhong Kong; Fiscal Year: 2010..be transmitted to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the ..
- Characterization of prion protein conformational changesVALERIE D DAGGETT; Fiscal Year: 2010..disease, fatal familial insomnia and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk. While rare, these diseases are always fatal...
- Role of Fetal Steroids in Formation and Activation of Bovine Ovarian FolliclesJoanne E Fortune; Fiscal Year: 2010..We have developed experimental models in which formation of bovine primordial follicles and development of their capacity to activate (i.e...
- Mechanism of membrane permeabilization by a cytolytic high density lipoproteinJOHN MATTHEW HARRINGTON; Fiscal Year: 2010..innate immunity against the mammalian parasite Trypanosoma brucei brucei, the causative agent of Nagana in African cattle. The morphologically indistinct T. brucei subspecies T. b. rhodesiense and T. b...
- RNA CAPPING IN TRYPANOSOMESChristian Tschudi; Fiscal Year: 2012..agents of African trypanosomiasis or sleeping sickness in humans and a wasting and fatal disease (Nagana) in cattle, domestic pigs and other farm animals causing a profound effect on the economy of much of the continent...
- Point-of-Care Diagnostic Assay for Direct Detection of Pathogenic LeptospiraJeffrey Smith; Fiscal Year: 2010..The World Health Organization lists the groups of people at risk of the infection ranging from cattle and pig farmers to veterinarians, butchers and slaughterhouse workers to children playing in rain puddles or mud, ..
- Epigenetic Modulation of PTPG by Zeranol in Beef Increases Breast Cancer RiskYoung C Lin; Fiscal Year: 2010..The overall HYPOTHESIS to be evaluated is that the consumption of beef products, derived from Z-implanted beef cattle may possess a potential health impact on human consumers, particularly with respect to reproductive endocrinology ..
- A Phase I Study to Evaluate the Safety and Immunogenicity of HPV 16 L2 11-200WARNER KING HUH; Fiscal Year: 2012..Vaccination of cattle with bovine papillomavirus type 4 (BPV4) L2 11-200 protects against BPV4 challenge on the soft palate...
- SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTINGShinichiro Kurosawa; Fiscal Year: 2011..There are certain strains of dangerous E. coli bacteria that can infect crops or cattle, and can be transmitted through our food distribution system to thousands of households...
- Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine FetusesKenneth L White; Fiscal Year: 2011..The incidence of immune-mediated abortion and placental insufficiency in both humans and cattle are greatly increased with the use of assisted reproductive technologies such as in vitro fertilization...
- The role of Variable Erythrocyte Surface Antigen (VESA1) proteins in Babesia boviKERRY SUE SONDGEROTH; Fiscal Year: 2011..This project will use Babesia bovis infection of cattle as a natural animal model of cytoadherence and virulence, and will address a significant knowledge gap to ..
- ANALYSIS OF TRYPANOSOME MRNA SYNTHESIS BY GENE TRANSFERVivian Bellofatto; Fiscal Year: 2010..In Africa, Trypanosoma brucei ssp. infect humans and domestic cattle, causing African sleeping sickness and Nagana, respectively. Human infection by the subspecies T. b...
- REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEICHING CHUNG WANG; Fiscal Year: 2012..are the causative pathogens of African sleeping sickness in humans and nagana in cattle. They are a family of deeply branched eukaryotes that exhibit many unique features during their cell cycle ..
- Structural Characterization of Prion Isoforms in Multiple TSE DiseasesMICHELE ANN MCGUIRL; Fiscal Year: 2012..Familial Insomnia, and kuru (humans), scrapie (sheep), chronic wasting disease (elk, deer), and mad cow disease (cattle)...
- Impact of Microparticles on Oral TSE InfectionsJoel A Pedersen; Fiscal Year: 2012..Microparticles are found in many other substances than soil. Meat and bone meal (MBM), a commonly used cattle food supplement thought responsible for BSE in Europe...
- LATENCY AND LEUKOMOGENICITY OF BOVINE LEUKEMIA VIRUSGary Cockerell; Fiscal Year: 1991b>Bovine leukemia virus (BLV) is an important, naturally occurring, endermic, retroviral disease of cattle, and a valuable comparative biomedical animal model of analogous human T cell lymphotropic retroviral (HTLV) infections...
- APRIL DAWN HUNT; Fiscal Year: 2014..The activities include: 1) reducing drug tissue residue violations in dairy cattle through a Hazard Analysis and Critical Control Points (HACCP) based approach;2) developing best practices for an ..
- REGULATION OF OTP-1 AND HCG GENES IN OVINE TROPHOBLASTGeorge Seidel; Fiscal Year: 1993..that communicate its presence to the mother have been identified: in sheep, ovine trophoblast protein-1 (oTP-1); cattle, (bTP- 1); and humans, human chorionic gonadotropin (hCG)...
- IDENTIFICATION OF BABESIA IMMUNOGENS WITH TH CELWendy Brown; Fiscal Year: 2000..Immunoregulatory mechanisms in cattle are much more like those of humans than mice, so this outbred large animal species provides an alternative system ..
- INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUMR Roberts; Fiscal Year: 1999..of embryo-derived interferons (IFN's) and other cytokines in triggering maternal responses to early sheep, cattle, pig and mouse embryos...
- Biosensor for Rapid Detection of PrionThomas Hazel; Fiscal Year: 2005..and Bovine Spongiform Encephalopathy are transmissible, neurodegenerative and fatal prion diseases of humans and cattle, respectively...
- MODELS OF HYPOXIC PULMONARY HYPERTENSIONArchibald Alexander; Fiscal Year: 1980..This response to hypoxia which occurs in most mammalian species including man, is particularly pronounced in cattle and also marked in swine...
- Producing Polyclonal Human Antibodies to AnthraxThillainayagam Sathiyaseelan; Fiscal Year: 2005..Hematech is developing a genetically modified line of cattle that will produce human instead of bovine immunoglobulin...
- CFI Inactivation of Human PlasmaTREVOR CASTOR; Fiscal Year: 2009..fluid inactivation) process inactivates enveloped viruses such as MuLV, VSV, TGE, BVD, Sindbis and HIV in fetal bovine serum by a lipid solubilization mechanism, similar to the solvent detergent method...
- Molecular Modulation of Catalytic Sites of Escherichia coli F1Fo ATP SynthaseZulfiqar Ahmad; Fiscal Year: 2009..b>Bovine X-ray crystal structure of catalytic sites indicates the presence of some other residues which seem to be involved ..
- Receptor/Ligand Signals for Ovarian Follicular AngiogenesisLeon J Spicer; Fiscal Year: 2010..In preliminary studies using experimental paradigms developed in our bovine granulosa and theca cell model, we demonstrated that: 1) abundance of ANG and FGF9 mRNA in bovine granulosa cells ..
- NEUROCHEMICAL CORRELATES OF CEREBELLAR DEVELOPMENTAndrej Rotter; Fiscal Year: 1992The aim of this proposal is to study the expression gamma-aminobutyric acid/benzodiazepine (GABA/BZ) receptors in bovine and murine cerebellum during development...
- QTL and QTL Genes Underlying Lactation PerformanceDarryl L Hadsell; Fiscal Year: 2010..Despite these findings, however, the genes that contribute to milk production are largely unidentified. In the bovine, there are quantitative trait loci (QTL) for milk volume present on all 29 autosomes...
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