Genomes and Genes
Alias: house mouse, Mus musculus, LK3 transgenic mice, Mus sp. 129SV, nude mice, transgenic mice, Mus muscaris, mice C57BL/6xCBA/CaJ hybrid, Mus musculus Linnaeus, 1758
Publications399 found, 100 shown here
- DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139E P Rogakou
Laboratory of Molecular Pharmacology, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 273:5858-68. 1998..Thus, gamma-H2AX formation is a rapid and sensitive cellular response to the presence of DNA double-stranded breaks, a response that may provide insight into higher order chromatin structures...
- VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic nicheRosandra N Kaplan
Department of Pediatrics and the Children s Blood Foundation Laboratories, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA
Nature 438:820-7. 2005..These findings demonstrate a requirement for VEGFR1+ haematopoietic progenitors in the regulation of metastasis, and suggest that expression patterns of fibronectin and VEGFR1+VLA-4+ clusters dictate organ-specific tumour spread...
- CTLA-4 control over Foxp3+ regulatory T cell functionKajsa Wing
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
Science 322:271-5. 2008..Thus, natural Tregs may critically require CTLA-4 to suppress immune responses by affecting the potency of antigen-presenting cells to activate other T cells...
- IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokinesJochen Schmitz
Schering Plough Biopharma Formerly DNAX Research, Inc, 901 California Avenue, Palo Alto, California 94304, USA
Immunity 23:479-90. 2005..In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs...
- In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like stateMarius Wernig
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Nature 448:318-24. 2007..Notably, the cells-derived from mouse fibroblasts-can form viable chimaeras, can contribute to the germ line and can generate live late-term embryos ..
- mTOR signaling in growth control and diseaseMathieu Laplante
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
Cell 149:274-93. 2012..Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation...
- Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identitiesSven Heinz
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Mol Cell 38:576-89. 2010....
- Control of regulatory T cell development by the transcription factor Foxp3Shohei Hori
Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
Science 299:1057-61. 2003..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
- Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsJason D Fontenot
Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
Nat Immunol 4:330-6. 2003..Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4+CD25- T cells. Thus, Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function...
- Fate mapping analysis reveals that adult microglia derive from primitive macrophagesFlorent Ginhoux
Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
Science 330:841-5. 2010..These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders...
- Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesLaurie E Harrington
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nat Immunol 6:1123-32. 2005..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
- Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasisMarta Pàez-Ribes
Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, 08907 L Hospitalet de Llobregat, Spain
Cancer Cell 15:220-31. 2009..Here we report that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitantly elicit tumor adaptation and ..
- Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 geneA Poltorak
Howard Hughes Medical Institute and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
Science 282:2085-8. 1998..Destructive mutations of Tlr4 predispose to the development of Gram-negative sepsis, leaving most aspects of immune function intact...
- Generation of germline-competent induced pluripotent stem cellsKeisuke Okita
Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
Nature 448:313-7. 2007We have previously shown that pluripotent stem cells can be induced from mouse fibroblasts by retroviral introduction of Oct3/4 (also called Pou5f1), Sox2, c-Myc and Klf4, and subsequent selection for Fbx15 (also called Fbxo15) ..
- Argonaute HITS-CLIP decodes microRNA-mRNA interaction mapsSung Wook Chi
Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nature 460:479-86. 2009..Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain...
- Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryGanesh M Shankar
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Med 14:837-42. 2008..We conclude that soluble Abeta oligomers extracted from Alzheimer's disease brains potently impair synapse structure and function and that dimers are the smallest synaptotoxic species...
- Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locusS Srinivas
Department of Genetics and Development, Columbia University, New York, USA
BMC Dev Biol 1:4. 2001....
- Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cellsAlexander Marson
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 134:521-33. 2008..These data reveal how key ES cell transcription factors promote the ES cell miRNA expression program and integrate miRNAs into the regulatory circuitry controlling ES cell identity...
- Interleukin-10 and the interleukin-10 receptorK W Moore
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
Annu Rev Immunol 19:683-765. 2001..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
- Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesUmut Ozcan
Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
Science 306:457-61. 2004..Using cell culture and mouse models, we show that obesity causes endoplasmic reticulum (ER) stress...
- A role for mitochondria in NLRP3 inflammasome activationRongbin Zhou
Department of Biochemistry, Center of Immunity and Infection, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nature 469:221-5. 2011..This indicates that NLRP3 inflammasome senses mitochondrial dysfunction and may explain the frequent association of mitochondrial damage with inflammatory diseases...
- A Toll-like receptor recognizes bacterial DNAH Hemmi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
Nature 408:740-5. 2000..The in vivo CpG-DNA-mediated T-helper type-1 response was also abolished in TLR9-/- mice. Thus, vertebrate immune systems appear to have evolved a specific Toll-like receptor that distinguishes bacterial DNA from self-DNA...
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsEstelle Bettelli
Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nature 441:235-8. 2006..Our data demonstrate a dichotomy in the generation of pathogenic (T(H)17) T cells that induce autoimmunity and regulatory (Foxp3+) T cells that inhibit autoimmune tissue injury...
- A central role for JNK in obesity and insulin resistanceJiro Hirosumi
Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Nature 420:333-6. 2002..improved insulin sensitivity and enhanced insulin receptor signalling capacity in two different models of mouse obesity. Thus, JNK is a crucial mediator of obesity and insulin resistance and a potential target for therapeutics.
- Combinatorial microRNA target predictionsAzra Krek
Center for Comparative Functional Genomics, Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
Nat Genet 37:495-500. 2005..In particular, we experimentally validate common regulation of Mtpn by miR-375, miR-124 and let-7b and thus provide evidence for coordinate microRNA control in mammals...
- Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1Mamta Tahiliani
Department of Pathology, Harvard Medical School and Immune Disease Institute, 200 Longwood Avenue, Boston, MA 02115, USA
Science 324:930-5. 2009..hmC is present in the genome of mouse embryonic stem cells, and hmC levels decrease upon RNA interference-mediated depletion of TET1...
- DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentM Okano
Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown 02129, USA
Cell 99:247-57. 1999..two recently identified DNA methyltransferases, Dnmt3a and Dnmt3b, are essential for de novo methylation and for mouse development...
- Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceTaichi Hara
Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
Nature 441:885-9. 2006....
- Efficient tumour formation by single human melanoma cellsElsa Quintana
Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
Nature 456:593-8. 2008..Modifications to xenotransplantation assays can therefore dramatically increase the detectable frequency of tumorigenic cells, demonstrating that they are common in some human cancers...
- ChIP-seq accurately predicts tissue-specific activity of enhancersAxel Visel
Genomics Division, MS 84 171, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Nature 457:854-8. 2009..protein p300 followed by massively parallel sequencing, and map several thousand in vivo binding sites of p300 in mouse embryonic forebrain, midbrain and limb tissue...
- WAF1, a potential mediator of p53 tumor suppressionW S El-Deiry
Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231
Cell 75:817-25. 1993..These studies define a gene whose expression is directly induced by p53 and that could be an important mediator of p53-dependent tumor growth suppression...
- Identification of stem cells in small intestine and colon by marker gene Lgr5Nick Barker
Hubrecht Institute, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
Nature 449:1003-7. 2007..The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers...
- Obesity induces a phenotypic switch in adipose tissue macrophage polarizationCarey N Lumeng
Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
J Clin Invest 117:175-84. 2007..Thus, diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance...
- Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasomeKiichi Nakahira
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Immunol 12:222-30. 2011..Our study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondrial integrity...
- Nanog safeguards pluripotency and mediates germline developmentIan Chambers
MRC Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, UK
Nature 450:1230-4. 2007..However, here we report that Nanog fluctuates in mouse embryonic stem cells...
- MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblastsThomas Thum
Department of Medicine I, Interdisziplinares Zentrum fur Klinische Forschung IZKF, University of Wuerzburg, 97080 Wuerzburg, Germany
Nature 456:980-4. 2008..In vivo silencing of miR-21 by a specific antagomir in a mouse pressure-overload-induced disease model reduces cardiac ERK-MAP kinase activity, inhibits interstitial fibrosis ..
- The ground state of embryonic stem cell self-renewalQi Long Ying
Center for Stem Cell and Regenerative Medicine, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, ZNI 529, Los Angeles, California 90033, USA
Nature 453:519-23. 2008In the three decades since pluripotent mouse embryonic stem (ES) cells were first described they have been derived and maintained by using various empirical combinations of feeder cells, conditioned media, cytokines, growth factors, ..
- TLR4 links innate immunity and fatty acid-induced insulin resistanceHang Shi
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 116:3015-25. 2006....
- Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genesJacqueline K White
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Cell 154:452-64. 2013..We describe a program, the Sanger Institute Mouse Genetics Project, that provides a step toward the aim of knocking out all genes and screening each line for a ..
- Autophagy regulates lipid metabolismRajat Singh
Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Nature 458:1131-5. 2009..components associated during nutrient deprivation, and inhibition of autophagy in cultured hepatocytes and mouse liver increased triglyceride storage in lipid droplets...
- IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAMarcella Calfon
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Nature 415:92-6. 2002..Purified mouse IRE1 accurately cleaved XBP-1 mRNA in vitro, indicating that XBP-1 mRNA is a direct target of IRE1 endonucleolytic ..
- Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammalsMitchell Guttman
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 458:223-7. 2009..Our approach identified approximately 1,600 large multi-exonic RNAs across four mouse cell types...
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismT Kitada
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
Nature 392:605-8. 1998..Mutations in the newly identified gene appear to be responsible for the pathogenesis of AR-JP, and we have therefore named the protein product 'Parkin'...
- A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesisPontus Boström
Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 481:463-8. 2012..Here we show in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is ..
- Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesS Sakaguchi
Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
J Immunol 155:1151-64. 1995..Abnormality of this T cell-mediated mechanism of peripheral tolerance can be a possible cause of various autoimmune diseases...
- The role of autophagy during the early neonatal starvation periodAkiko Kuma
Time s Arrow and Biosignaling, PRESTO, Japan Science and Technology Agency, Kawaguchi 332 0012, Japan
Nature 432:1032-6. 2004..These results suggest that the production of amino acids by autophagic degradation of 'self' proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation...
- A global double-fluorescent Cre reporter mouseMandar Deepak Muzumdar
Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Genesis 45:593-605. 2007..Here we describe mT/mG, a double-fluorescent Cre reporter mouse that expresses membrane-targeted tandem dimer Tomato (mT) prior to Cre-mediated excision and membrane-targeted ..
- hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylaseH Vaziri
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Cell 107:149-59. 2001..In contrast, expression of a catalytically inactive hSir2 protein potentiates p53-dependent apoptosis and radiosensitivity. We propose that hSir2 is involved in the regulation of p53 function via deacetylation...
- OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphomaPedro P Medina
Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520, USA
Nature 467:86-90. 2010..These results demonstrate that tumours can become addicted to oncomiRs and support efforts to treat human cancers through pharmacological inactivation of miRNAs such as miR-21...
- Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisD R Rosen
Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown 02129
Nature 362:59-62. 1993..Given this linkage and the potential role of free radical toxicity in other neurodenegerative disorders, we investigated SOD1 as a candidate gene in FALS. We identified 11 different SOD1 missense mutations in 13 different FALS families...
- p53, the cellular gatekeeper for growth and divisionA J Levine
Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544, USA
Cell 88:323-31. 1997
- Polycomb proteins targeted by a short repeat RNA to the mouse X chromosomeJing Zhao
Howard Hughes Medical Institute, Boston, MA 02115, USA
Science 322:750-6. 2008..Likewise, PRC2 deficiency compromises Xist up-regulation. Therefore, RepA, together with PRC2, is required for the initiation and spread of XCI. We conclude that a ncRNA cofactor recruits Polycomb complexes to their target locus...
- MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiationYvonne Tay
Stem Cell and Developmental Biology, Genome Institute of Singapore, Agency for Science Technology and Research, 08 01, Genome, 60 Biopolis Street, Singapore 138672, Singapore
Nature 455:1124-8. 2008..Here we focus on the mouse Nanog, Oct4 (also known as Pou5f1) and Sox2 genes and demonstrate the existence of many naturally occurring miRNA ..
- Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic miceL Mangiarini
Division of Medical and Molecular Genetics, UMDS, Guy s Hospital, London, United Kingdom
Cell 87:493-506. 1996..In three lines, the transgene is ubiquitously expressed at both mRNA and protein level. Transgenic mice exhibit a progressive neurological phenotype that exhibits many of the features of HD, including choreiform-..
- Fission and selective fusion govern mitochondrial segregation and elimination by autophagyGilad Twig
Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA
EMBO J 27:433-46. 2008..Together, these findings suggest that fission followed by selective fusion segregates dysfunctional mitochondria and permits their removal by autophagy...
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsPeter Duewell
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 464:1357-61. 2010..These findings provide new insights into the pathogenesis of atherosclerosis and indicate new potential molecular targets for the therapy of this disease...
- The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylationVidisha Tripathi
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Mol Cell 39:925-38. 2010..Taken together, our results suggest that MALAT1 regulates AS by modulating the levels of active SR proteins. Our results further highlight the role for an nrRNA in the regulation of gene expression...
- Paneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsToshiro Sato
Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
Nature 469:415-8. 2011..In colon crypts, CD24(+) cells residing between Lgr5 stem cells may represent the Paneth cell equivalents. We conclude that Lgr5 stem cells compete for essential niche signals provided by a specialized daughter cell, the Paneth cell...
- Biologic basis for interleukin-1 in diseaseC A Dinarello
Department of Medicine, Tufts University, Boston, MA USA
Blood 87:2095-147. 1996..At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease...
- Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationD L Lacey
Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
Cell 93:165-76. 1998..These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development...
- Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasisSeth Rakoff-Nahoum
Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Cell 118:229-41. 2004..These findings reveal a novel function of TLRs-control of intestinal epithelial homeostasis and protection from injury-and provide a new perspective on the evolution of host-microbial interactions...
- HITS-CLIP yields genome-wide insights into brain alternative RNA processingDonny D Licatalosi
Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nature 456:464-9. 2008..analysis of the neuron-specific splicing factor Nova revealed extremely reproducible RNA-binding maps in multiple mouse brains...
- Requirement of hippocampal neurogenesis for the behavioral effects of antidepressantsLuca Santarelli
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
Science 301:805-9. 2003..X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants...
- c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cellsZuqin Nie
Laboratory of Pathology, NCI, Bethesda, MD 20892, USA
Cell 151:68-79. 2012..This rule of Myc action explains the vast majority of Myc biology observed in literature...
- Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Rashu B Seth
Howard Hughes Medical Institute, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cell 122:669-82. 2005..The transmembrane domain targets MAVS to the mitochondria, implicating a new role of mitochondria in innate immunity...
- Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheToshiro Sato
Hubrecht Institute and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
Nature 459:262-5. 2009..We conclude that intestinal cryptvillus units are self-organizing structures, which can be built from a single stem cell in the absence of a non-epithelial cellular niche...
- Restoring function in exhausted CD8 T cells during chronic viral infectionDaniel L Barber
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Nature 439:682-7. 2006..These studies identify a specific mechanism of T-cell exhaustion and define a potentially effective immunological strategy for the treatment of chronic viral infections...
- Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutationM E Gurney
Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
Science 264:1772-5. 1994..to alanine at position 93--a change that has little effect on enzyme activity--caused motor neuron disease in transgenic mice. The mice became paralyzed in one or more limbs as a result of motor neuron loss from the spinal cord and ..
- Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunctionSalvatore Oddo
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, USA
Neuron 39:409-21. 2003....
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayLijun Sun
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 339:786-91. 2013..cGAS bound to DNA in the cytoplasm and catalyzed cGAMP synthesis. These results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP...
- Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosineShinsuke Ito
Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
Science 333:1300-3. 2011..Furthermore, we reveal the presence of 5fC and 5caC in genomic DNA of mouse embryonic stem cells and mouse organs...
- p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell deathGeir Bjørkøy
Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
J Cell Biol 171:603-14. 2005..We suggest that p62 may, via LC3, be involved in linking polyubiquitinated protein aggregates to the autophagy machinery...
- A gene expression atlas of the central nervous system based on bacterial artificial chromosomesShiaoching Gong
GENSAT Project, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 260, New York 10021, USA
Nature 425:917-25. 2003..The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously ..
- AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCVeit Hornung
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 458:514-8. 2009..Using mouse and human cells, here we identify the PYHIN (pyrin and HIN domain-containing protein) family member absent in ..
- Mediator and cohesin connect gene expression and chromatin architectureMichael H Kagey
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 467:430-5. 2010..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell...
- The protein kinase complement of the human genomeG Manning
SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
Science 298:1912-34. 2002..We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons...
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1Joungmok Kim
Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92130, USA
Nat Cell Biol 13:132-41. 2011..This coordinated phosphorylation is important for Ulk1 in autophagy induction. Our study has revealed a signalling mechanism for Ulk1 regulation and autophagy induction in response to nutrient signalling...
- Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contributionNimet Maherali
Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Harvard Stem Cell Institute, 185 Cambridge Street, Boston, MA 02114, USA
Cell Stem Cell 1:55-70. 2007....
- Roles of CHOP/GADD153 in endoplasmic reticulum stressS Oyadomari
Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
Cell Death Differ 11:381-9. 2004..Here, we summarize the current understanding of the roles of CHOP/GADD153 in ER stress-mediated apoptosis and in diseases including diabetes, brain ischemia and neurodegenerative disease...
- Metabolic endotoxemia initiates obesity and insulin resistancePatrice D Cani
Institute of Molecular Medicine, I2MR Toulouse, France
Diabetes 56:1761-72. 2007..We conclude that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity. Lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases...
- Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specificationShinsuke Ito
Howard Hughes Medical Institute
Nature 466:1129-33. 2010..Here we extend this study by demonstrating that all three mouse Tet proteins (Tet1, Tet2 and Tet3) can also catalyse a similar reaction...
- TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionLiang Zhou
The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
Nature 453:236-40. 2008..in naive CD4+ T cells exposed to TGF-beta and in a subset of T cells in the small intestinal lamina propria of the mouse. In vitro, TGF-beta-induced Foxp3 inhibits RORgammat function, at least in part through their interaction...
- Blinded by the Light: The Growing Complexity of p53Karen H Vousden
The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
Cell 137:413-31. 2009..Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53...
- Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylaseAnne Brunet
Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
Science 303:2011-5. 2004..Thus, one way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance...
- Induction of colonic regulatory T cells by indigenous Clostridium speciesKoji Atarashi
Department of Immunology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
Science 331:337-41. 2011....
- Transforming growth factor-beta induces development of the T(H)17 lineagePaul R Mangan
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
Nature 441:231-4. 2006..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages...
- Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily memberA C McPherron
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 387:83-90. 1997..These results suggest that GDF-8 functions specifically as a negative regulator of skeletal muscle growth...
- Mdm2 promotes the rapid degradation of p53Y Haupt
Lautenberg Center for General and Tumor Immunology, The Hebrew University Haddassah Medical School, Jerusalem, Israel
Nature 387:296-9. 1997..During recovery from DNA damage, maximal Mdm2 induction coincides with rapid p53 loss. We propose that the Mdm2-promoted degradation of p53 provides a new mechanism to ensure effective termination of the p53 signal...
- A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNAMarcella Cesana
Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Italy
Cell 147:358-69. 2011..long noncoding RNA, linc-MD1, which governs the time of muscle differentiation by acting as a ceRNA in mouse and human myoblasts...
- Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseH P Harding
Skirball Institute of Biomolecular Medicine, Department of Medicine, NYU School of Medicine, New York 10016, USA
Nature 397:271-4. 1999..These properties implicate PERK in a signalling pathway that attenuates protein translation in response to ER stress...
- Identification and expansion of human colon-cancer-initiating cellsLucia Ricci-Vitiani
Department of Hematology and Oncology, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
Nature 445:111-5. 2007..We conclude that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies...
- Gout-associated uric acid crystals activate the NALP3 inflammasomeFabio Martinon
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
Nature 440:237-41. 2006..These findings provide insight into the molecular processes underlying the inflammatory conditions of gout and pseudogout, and further support a pivotal role of the inflammasome in several autoinflammatory diseases...
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growthHeather R Christofk
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 452:230-3. 2008..production and increased oxygen consumption, and this correlates with a reduced ability to form tumours in nude mouse xenografts...
- Nuocytes represent a new innate effector leukocyte that mediates type-2 immunityDaniel R Neill
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Nature 464:1367-70. 2010..Thus, nuocytes represent a critically important innate effector cell in type-2 immunity...
- Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acidDaniel Mucida
La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Science 317:256-60. 2007..These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity...
- PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagyNoriyuki Matsuda
Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Setagaya Ku, Tokyo 156 8506, Japan
J Cell Biol 189:211-21. 2010..Some pathogenic mutations of PINK1 and Parkin interfere with the aforementioned events, suggesting an etiological importance. These results provide crucial insight into the pathogenic mechanisms of PD...
- A multigenic program mediating breast cancer metastasis to boneYibin Kang
Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Cancer Cell 3:537-49. 2003....
- A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismJanine L Coombes
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
J Exp Med 204:1757-64. 2007..These results newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repertoire of T reg cells focused on the intestine...
- Loss of autophagy in the central nervous system causes neurodegeneration in miceMasaaki Komatsu
Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
Nature 441:880-4. 2006..Our results indicate that autophagy is essential for the survival of neural cells, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies...
- Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathwaysTamer T Onder
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
Cancer Res 68:3645-54. 2008..These findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes...
- Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1J A Forsythe
Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
Mol Cell Biol 16:4604-13. 1996..VEGF mRNA was not induced by hypoxia in mutant cells that do not express the HIF-1beta (ARNT) subunit. These findings implicate HIF-1 in the activation of VEGF transcription in hypoxic cells...
Research Grants150 found, 100 shown here
- Effector IEG, Homer and Drug AddictionPaul F Worley; Fiscal Year: 2010..of NIDA RO1-11742, and will advance our understanding of the role of Homer in drug^-addiction using transgenic mouse models...
- MECHANISMS OF RETINAL SYNAPTIC PLASTICITYDouglas McMahon; Fiscal Year: 2009..Aim II. Using a transgenic mouse model developed in our laboratory that enables in situ recording from dopaminergic amacrine neurons (DA neurons), ..
- Animal models to study iron homeostasisRuben Vidal; Fiscal Year: 2010..be achieve in other cell populations or organ systems using our "floxed" ferritin mice in combination with transgenic mice expressing the CreERT2 protein under the control of specific promoters...
- Hypothalamic glucokinase in obesity and diabetesCharles V Mobbs; Fiscal Year: 2010..address this hypothesis, in Specific Aim 1 we propose to ablate GK specifically from POMC neurons by crossing transgenic mice expressing cre-recombinase under control of the POMC promoter (POMC-cre) with mice in which the GK gene is ..
- Mouse models of age-associated monoclonal gammopathyPETER BERGSAGEL; Fiscal Year: 2009..Finally, using novel transgenic mice, we will functionally study the role of activation of RAS and dysregulation of cyclin D1 in the progression ..
- Neuropeptide Modulation of Taste SignalsNirupa Chaudhari; Fiscal Year: 2010..We will conduct these analyses in wild-type and transgenic mice, PLC22-GFP, GAD-GFP and OxtR-YFP...
- Gamma-Synuclein-Mediated Regulation of Norepinephrine TransporterAnita Sidhu; Fiscal Year: 2010..Syn overexpressing transgenic mice, as well as in .-Syn knock-out mice...
- Mechanisms of Selective Neurodegeneration in Parkinson DiseaseXugang Xia; Fiscal Year: 2010..To test proposed mechanisms of dopaminergic neuron death in PD, we have created two novel mouse lines: DAT-CreERT2 transgenic mouse and conditional VMAT2 knockout mouse...
- Role of basal ganglia circuit imbalance in the expression of OCD-like behaviorsJonathan T Ting; Fiscal Year: 2010..Specific Aim 1 will make use of the recently described SAPAP3 knockout mouse model of OCD-like behavior, which was developed in our lab (Welch et al, 2007 Nature)...
- Inducible Macrophage Specific Gene Expression in DiseasesJEANINE M D apos ARMIENTO; Fiscal Year: 2010..Our laboratory has developed a new transgenic mouse model targeting Cre recombinase expression in tissue macrophage, using the scavenger receptor A promoter (SRA-Cre)...
- Glutathione in mitochondrial dysfunction and disease progression in ALS-modelsMarcelo R Vargas; Fiscal Year: 2011..The decrease in life span seems to be associated with aggravated mitochondrial pathology commonly observed in transgenic mice overexpressing mutated forms of hSOD1 that retain superoxide dismutase activity...
- E-Prostanoid Receptor Subtype 2 (EP2) Regulation of Microglial ActivationPatrick J Cimino; Fiscal Year: 2011..Recently we demonstrated that genetic ablation of the EP2 receptor from primary mouse microglia resulted in the highly desirable dual phenotype of an increase in phagocytosis of Abeta species and ..
- REGULATION OF CELLULAR RESPONSES TO NEUROPEPTIDESNigel W Bunnett; Fiscal Year: 2010..in transfected cell lines, endothelial cells and enteric neurons in short-term culture, and in knockout and transgenic mice. Aim 1 will define the molecular mechanism of SP-stimulated endocytosis and intracellular trafficking of the ..
- Conte Centers for the Neuroscience of DepressionRanga R Krishnan; Fiscal Year: 2010..The final project is designed to assess in these transgenic mice using multielectrode array of single neuron recordings of the firing pattern of the circuit neurons in ..
- Interleukin-1 (IL-1) Receptor-Mediated Modulation of Serotonin TransportersRandy D Blakely; Fiscal Year: 2011..We have shown that IL-1[unreadable] stimulates SERT activity in a raphe cell line as well as in mouse synaptosomes ex vivo...
- Photic and Circadian Regulation of Retinal MelatoninGianluca Tosini; Fiscal Year: 2010..In the last few months we have developed a unique in vitro preparation and a series of transgenic mice in which the role of melatonin in the retina can be tested...
- Neurogenesis: Career Development Plan in the Genetic and Modeling of MicrocephalySTEPHANIE LEE BIELAS; Fiscal Year: 2011..vitro modeling data to in vivo brain development, I propose to utilize a combination of patient iPSCs, transgenic mouse iPSCs and animal models...
- Transcription factors regulating sensory gene expression and pain pathwaysEric E Turner; Fiscal Year: 2011..To determine the complete set of pain pathway genes dependent on Islet1, we will use transgenic mice expressing an inducible Cre-recombinase from the Islet1 gene locus to delete Islet1 after sensory ..
- Regulation of Neuronal Survival by the Rit GTPaseDOUGLAS ALLEN ANDRES; Fiscal Year: 2012..Using primary neurons from two transgenic mouse models either expressing activated Rit specifically in neurons or a homozygous Rit knockout mouse (developed ..
- Histone Deacetylases: Regulators of Cocaine Reward and Targets for TherapeuticsMARCELO ANDRES WOOD; Fiscal Year: 2012..that avoid developmental and performance issues that arise from traditional knockout mice or even most transgenic mice. The focus of Aim 2 is to examine the ability of a novel class of HDAC inhibitors that are selective for ..
- Insulin and IGF-1 regulation of the GnR H neuronSara A DiVall; Fiscal Year: 2012..IGF-1 increases c-fos mRNA in vitro whereas insulin does not. In fasted transgenic mice, insulin treatment increases mouse GnRH promoter activity...
- Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null MicYuqing Li; Fiscal Year: 2010..The broad, long- term objective of our research is to use transgenic mice to determine: 1) the functional role of BTBD9 protein in vivo, 2) how the alteration of BTBD9 protein ..
- Regulation of BimEL phosphorylation in the pathogenesis of Huntington's diseaseJianning Wei; Fiscal Year: 2012..This will be achieved by crossing R6/2 mice with BDNF transgenic mice (BTg)...
- Rubin M Tuder; Fiscal Year: 2015..These aims rely on a translational and comprehensive approach that includes knockout and transgenic mice, in vivo and in vitro manipulation of RTP801/mTOR/AKT gene expression and signaling with adenoassociated ..
- Targeted investigation of tissue specific oxidative stress in the etiology of ALSHolly Van Remmen; Fiscal Year: 2013..rotarod, motor neuron numbers, loss of muscle innervation) and lifespan in wild type control mice, G93A1Gur transgenic mice, Gpx4flfl mice x tissue specific Cre mice and G93A1Gur Gpx4flfl x tissue specific Cre mice...
- Cellular Functions of ParkinJian Feng; Fiscal Year: 2013..To investigate the cellular functions of parkin both in vitro and in vivo, we will use cell lines, parkin transgenic mice, parkin knockout mice, and cells derived from PD patients with parkin mutations...
- Clifford J Woolf; Fiscal Year: 2016..if forced expression of ATF3 in postnatal non-injured DRG neurons increases pain-related sensitivity, using transgenic mice with the ATF3 gene under control of a neuron-specific thy1.2 regulatory sequence. 2...
- Guo fu Hu; Fiscal Year: 2014..angiogenin during development and in ALS pathology;2) generate tissue- and time-specific ANG:SOD1G93A double transgenic mice and examine the effect of ANG overexpression on SOD1G93A-induced motor neuron toxicity;and 3) optimize the ..
- LAXMAN DASS GANGWANI; Fiscal Year: 2014..Zpr1 (F1/F1) mice with transgenic Hb9-cre mice expressing Cre recombinase under the control of endogenous mouse Hlxb9 promoter. Aim 2...
- Development of a conditional T1MP-1 knockout mouseStephen J Crocker; Fiscal Year: 2013..differentially impact neuropathology, we will develop an essential new reagent: a conditional TIMP-1 knockout mouse (TIMP-1cKO) line...
- Stefano Vicini; Fiscal Year: 2014..Using transgenic mice with the two major striatal output pathways labeled, we will have a unique opportunity to answer a ..
- Teepu Siddique; Fiscal Year: 2016..and behavioral deficits and decreased long term potentiation in far field recordings were observed in transgenic mice expressing a pathogenic UBQLN2 mutation (P497H)...
- Clinton C MacDonald; Fiscal Year: 2015..components, and test functions of DCstF-64 domains using a luciferase-based cell transfection assay and transgenic mice. PUBLIC HEALTH RELEVANCE: The most heartbreaking of disorders can be infertility, when a couple fails to ..
- Peter Leif Bergsagel; Fiscal Year: 2014..Finally, using novel transgenic mice, we will functionally study the role of activation of RAS and dysregulation of cyclin D1 in the progression ..
- Mary B Goldring; Fiscal Year: 2014..progression of OA in mouse knee joints due to aging or surgical OA? We will generate Tet-Off-inducible Ese1 transgenic mice to examine whether excess ESE-1, by itself, initiates or accelerates surgically induced OA and reveal if ESE-..
- Richard M Ransohoff; Fiscal Year: 2015..art mouse models of A? and MAPT pathologies, as well as CXC3CR1 knockout mice and CX3CL1 knockouts and transgenic mice to examine the effects of biochemistry, gene expression, neuropathology and behavior...
- Function of KLF4-expressing stem cells in mouse cutaneous wound healingWalden Ai; Fiscal Year: 2013..This proposal focuses on testing the hypothesis that KLF4- expressing stem cells have a critical function in mouse cutaneous wound healing...
- MARCEL WUETHRICH; Fiscal Year: 2015..We have created a novel Blastomyces TCR transgenic mouse, which represents a key innovation that will let us analyze the requirements for differentiation of naive anti-..
- Shiyou Chen; Fiscal Year: 2014..The role of RGC-32 in SMC differentiation will be determined using RGC-32 knockout mouse model...
- Avtar K Singh; Fiscal Year: 2015..will be further examined and validated using AMPK alpha 1/2 knockout mice, AMPK alpha over-expressing transgenic mice, and wild type mice...
- Jeanine L Frey; Fiscal Year: 2014..role of Siva in tumor suppression, we will cross the Siva conditional knockout mice to E[unreadable]-myc transgenic mice, which are prone to B-cell lymphomagenesis and in which p53-mediated apoptosis is central for tumor ..
- Joan Heller Brown; Fiscal Year: 2016..The proposed work is divided into three Specific Aims. Aim #1 characterizes several lines of transgenic mice expressing constitutively active RhoA in an inducible cardiac specific manner, comparing the ability of RhoA ..
- Hoon Ryu; Fiscal Year: 2015..Our preliminary data shows that that brain CBP levels are reduced in HD transgenic mice and we confirmed, as reported by others, that mutant htt sequesters CBP...
- Sten Cell Gene Therapy of Breast CancerANDRE MICHAEL LIEBER; Fiscal Year: 2013..We will test our hypotheses in a mouse model of breast cancer involving rat neu-transgenic mice (neu-tg) and syngeneic mammary carcinoma cells (MMC)...
- Varykina G Thackray; Fiscal Year: 2015..In Specific Aim 1, a pituitary-specific knockout mouse model will be used to determine whether FoxO1 expression in the gonadotrope is necessary for fertility and whether ..
- Molecular mechanism underlying Frontotemporal Lobar RegenerationDavid Medina; Fiscal Year: 2013..We will use a pharmacological approach to increase autophagy in transgenic mice expressing mutant TDP-43 that exhibit cognitive and motor deficits as well as TDP-43 accumulation...
- PABLO MARTIN PAEZ; Fiscal Year: 2016..2 mice with the NG2CreERTM transgenic mice which express a tamoxifen-inducible Cre recombinase under the control of the mouse NG2 promoter...
- Huaxi Xu; Fiscal Year: 2016..change in the activity, concentration or localization of appoptosin in the brain samples of AD patients and transgenic mice to establish a direct link between appoptosin and AD...
- ROBERT A LAFYATIS; Fiscal Year: 2015..experiments will examine the importance of T cells, macrophages and dendritic cells, using rag1 deficient or transgenic mice inducibly deleted of macrophages or dendritic cells...
- The Role of the Central Melanocortin System in the Muscle Wasting of CachexiaTHEODORE PAUL BRAUN; Fiscal Year: 2013..Pseudorabies virus will be injected into muscle of MC4R-GFP transgenic mice, and infection of MC4R-positive neurons in the hypothalamus will be examined...
- Ajit K Verma; Fiscal Year: 2015..We reported that epidermal PKC5 level dictates the susceptibility of transgenic mice to the development of SCC elicited either by the repeated exposure to UVR or by the DMBA - TPA tumor ..
- Zhengui Xia; Fiscal Year: 2014..Our collaborator, Dr. Richard Palmiter, recently generated a transgenic mouse strain lacking functional Ndufs4, a gene encoding a subunit required for complete assembly and function of complex ..
- Marcelo R Vargas; Fiscal Year: 2014..The decrease in life span seems to be associated with aggravated mitochondrial pathology commonly observed in transgenic mice overexpressing mutated forms of hSOD1 that retain superoxide dismutase activity...
- Role of hepatic and pulmonary P4501A enzymes in neonatal hyperoxic tissue injuryXANTHI IOANNA COUROUCLI; Fiscal Year: 2013..Using knockout and transgenic mice, and cell culture models, this project is aimed at developing novel approaches for the prevention and ..
- Todd N Eagar; Fiscal Year: 2016..the role(s) of ?-secretase and Notch signaling we will utilize T cell and B cell-specific Cre recombinase transgenic mice we will generate conditional knockout mice that lack ?-secretase functions by disrupting Presenilin 1 (the ..
- Aging, Microglial Dysregulation and DepressionJonathan P Godbout; Fiscal Year: 2013..To address these issues, we propose three specific aims using a BALB/c mouse model of aging and a FNKR-/- transgenic mouse model of impaired microglia regulation...
- SVIP and CMT1AJun Li; Fiscal Year: 2013..how SVIP regulates protein degradation in myelin in vivo by investigating Svip knockout and Pmp22 transgenic mice. Second, results should establish a pathogenic signaling pathway responsible for abnormal protein aggregation ..
- Yong Shen; Fiscal Year: 2014..We will use the double transgenic mouse model, APP23/TNFRII-/-, to examine whether these mice exhibit earlier AD-like pathology...
- KRISTEN RACHEL VELLA; Fiscal Year: 2014..These mutant receptors are targeted to specific subsets of neurons using the Cre-LoxP recombination system in transgenic mice. By administering CNO to mice expressing DREADDs in NPY or MC4R neurons, this technology will pinpoint the ..
- John F Neumaier; Fiscal Year: 2014..In Aim 1 we will construct the targeting construct, express it via homologous recombination, derive transgenic mice, and characterize the behavioral phenotype of the mice...
- Joseph M Miano; Fiscal Year: 2016..to lipid accumulation and inflammatory gene expression in vitro and neointimal disease when overexpressed in transgenic mice. Further, AKAP12A augments MYOCD-dependent transactivation, a key molecular process in the differentiation of ..
- Bogoljub Ciric; Fiscal Year: 2014..However, transgenic mice that report GM-CSF expression do not exist, and Specific Aim 1 of this proposal is to generate such mice...
- Variation in M. tuberculosis in response to host selectionSarah Fortune; Fiscal Year: 2009..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
- Subbiah Pugazhenthi; Fiscal Year: 2016..In a recent study with AD post-mortem samples and Alzheimer's transgenic mice, we identified the decrease of hippocampal CREB expression by A[unreadable]-generated oxidative stress as a ..
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- NIH Director's Pioneer AwardJunying Yuan; Fiscal Year: 2009..No Abstract provided ..
- STAT3 and astrogliogenesis in HIV-1 associated dementiaHui Peng; Fiscal Year: 2010..using a primary human NPC culture system and a severe combined immune deficient (SCID) HIV-1 encephalitis (HIVE) mouse model...
- Adenosine Receptors and AtherogenesisKatya Ravid; Fiscal Year: 2012..To further address this, we generated the first A2bAR-knockout (KO)/reporter gene-knock-in mouse model and showed reported gene expression primarily in VSMC and macrophages, in accordance with the endogenous ..
- Role of Brain-Specific microRNAs in Suppression of Autoimmune NeuroinflammationHoward L Weiner; Fiscal Year: 2013..investigate whether suppression of EAE is related to induction of regulatory subsets of myeloid cells or T cells in vivo and will investigate the treatment of relapsing and progressive EAE mouse models with miR-124. 1
- JIALIN CHARLES ZHENG; Fiscal Year: 2014..and mitochondrial stress inhibitors will be examined in a severe combined immune deficient HIV-1 encephalitis mouse model...
- Jason C Mills; Fiscal Year: 2016..receptor modulator tamoxifen causes ablation of nearly all parietal cells, the acid-secreting lineage, in the mouse stomach within 3 days...
- Knockdown of Gene Expression in Immune Cells in Humanized MiceJudy Lieberman; Fiscal Year: 2010..amongst the most highly evolving genes and the cytokine and chemokine responses in mice and humans often differ, mouse immune responses often differ qualitatively from human responses...
- Yaya Wang; Fiscal Year: 2014..In Aim 2, I will address the impact of LypW on TLR signaling by using BMMs and BMDCs from LypW transgenic mice. I will also investigate the role of LypW in pathogenesis of rheumatoid arthritis using the K/BxN TCR ..
- TIMOTHY CRAGIN WANG; Fiscal Year: 2015..IMCs accumulate in early stages of mouse and human colonic neoplasia, due to downregulation of HDC gene expression by cancer cells leading to inhibition of ..
- Timothy L Denning; Fiscal Year: 2016..and dendritic cells (DCs) that differ phenotypically, functionally, and regionally along the length of the mouse intestine during homeostasis and inflammation...
- DEBROSKI R HERBERT; Fiscal Year: 2016..Notably, we have demonstrated that IL-4/IL-13-driven MF activity prevents lethal immunopathology in mouse schistosomiasis...
- Tumor Microenvironment Interactions in Brain TumorsEric C Holland; Fiscal Year: 2010..In Aim 3 we will determine if the Gli-luc mouse line can be used for bioluminescence imaging to visualize recruitment and SHH signaling in gliomas overtime...
- Gadiparthi N Rao; Fiscal Year: 2016..that besides VEGFA, VEGFB, VEGFC, DLL4 and cleaved NOTCH1 induction, hypoxia activates CREB and STAT3 in the mouse retina in a robust and sustained manner...
- A combined drug and neural stem cell delivery approach for treating strokeKyle J Lampe; Fiscal Year: 2013..This proposal will utilize a new protein-based biomaterial to 1) direct mouse neural stem cell (NSC) growth, 2) tailor drug delivery, and 3) deliver NSCs to a stroke lesion site in a mouse ..
- Cellular and Genetic Correlates of Increased Head Size in Autism Spectrum DisordeFlora M Vaccarino; Fiscal Year: 2012..In Specific Aim 3, we will transplant NSCs from control and patients into the ventricles of mouse embryos in order to determine their in vivo phenotype and their ability to contribute neurons to various brain ..
- Cellular and Genetic Correlates of Increased Head Size in Autism Spectrum DisordeFlora M Vaccarino; Fiscal Year: 2010..In Specific Aim 3, we will transplant NSCs from control and patients into the ventricles of mouse embryos in order to determine their in vivo phenotype and their ability to contribute neurons to various brain ..
- Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory TherALEXANDRA ROSE LUCAS; Fiscal Year: 2010..we will conduct an intensive analysis into the role of thrombolytic serine proteases, serpins and receptors in mouse models of aggressive vasculitic disorders, specifically Giant Cell Temporal Arteritis (GCTA) and Takayasu's ..
- Kamal A Mohammed; Fiscal Year: 2014..We propose to study the mechanisms of pleural fibrosis in a HO-1 knock out mouse model because defective HO-1 expression was associated with increased susceptibility to bacterial pneumonia in an ..
- Control of Colonic Inflammation and Tumor Growth by TGFBeta and Dietary Vitamin DLillian Maggio-Price; Fiscal Year: 2012..Few mouse models mimic inflammation and large bowel cancer in humans, and yet human patients with gastrointestinal ..
- Claire Larmonier; Fiscal Year: 2014..A novel mouse model for conditional cell-type specific Parp1 targeting, Parp1/Rag1 double knockout mice, and bone marrow ..
- CHANGHYON CHRIS YUN; Fiscal Year: 2015..We will generate LPA2R transgenic mice to determine the effects of LPA2R overexpression on tumor development in the intestine...
- Microbial regulation of intestinal gene expression through microRNASushila Dalal; Fiscal Year: 2012..I will first determine if the enteric bacteria alter miRNA profiles in the mouse colonic epithelium though comparison of the microRNA expression in germ free mice to the expression in germ free ..
- Coronavirus modulation of cellular microRNAs in the liver: role in hepatitisSonia Navas-Martin; Fiscal Year: 2012..upon in vitro infection with various strains of murine CoVs that induce different hepatitis outcome in the mouse (from minimal inflammation to fulminant hepatitis)...
- Prasanna Krishnamurthy; Fiscal Year: 2016..research is based on preliminary observations that 1) prolonged inflammation impairs tube formation ability of mouse BM-derived EPCs, in vitro 2) miRNA array data from EPCs, in response to inflammatory stimuli, indicates an up-..
- Richard C Wang; Fiscal Year: 2016..Finally, we wil use mouse models with keratin defects (both deletions and mutations) to test whether impaired autophagy contributes to ..
- Aldose Reductase: A Regulator of Inflammatory SignalsKOTA VENKATA RAMANA; Fiscal Year: 2011..secretion of cytokines such as TNF-alpha, IL-6, and IL-10, secondary messenger cAMP and prostaglandin E2 in mouse peritoneal macrophages...
- TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic DisordersAndrew S Greenberg; Fiscal Year: 2010..and metabolic phenotype of TPLKO mice in two separate models of obesity: 1) high fat diet (HFD) and 2) the ob/ob mouse, a genetic model of murine obesity...
- Novel mouse models of inflammation-resolutionPaul L Fox; Fiscal Year: 2010..In new Preliminary Studies we show that the GAIT pathway is functional in mouse macrophages;however, the mouse GAIT complex is heterotrimeric, lacking NSAP1 and early negative regula- tion...
- Val S Goodfellow; Fiscal Year: 2014..2 research we will optimize these compounds for MLK3 potency, specificity, oral bioavailability and activity in mouse brain imaging models of HIV-Tat challenge...
- The Role of Beta-Arrestins 1 and 2 in Rheumatoid ArthritisHongkuan Fan; Fiscal Year: 2010..dendritic cells (DC)s, polymorphonuclear leukocyte (PMN)s and FLS correlation to the disease severity in the mouse CIA model will be examined...
- miRNAs regulate lung epithelial progenitor cells in development and injury repairYing Tian; Fiscal Year: 2013..loss-of-miR-302/367 on lung epithelial progenitor cell development using ROSA-miR- 302/367 and floxed miR-302/367 mouse lines...
- Iris Z Jaffe; Fiscal Year: 2016..In these two mouse models, the mechanism by which PlGF mediates aldo-stimulated vascular disease will be explored by comparing mice ..
- Targeting renal inflammatory pathways of SLE nephritis in mouse and manAnne Davidson; Fiscal Year: 2013..Because SLE patients differ from each other with respect to the patterns of kidney disease we will use several mouse models of SLE nephritis to understand more about the mechanisms for kidney inflammation and remission in different ..
- PNG LOKE; Fiscal Year: 2016..the Aldh1a2 deficient mice are embryonically lethal, we have also designed and generated a transgenic reporter mouse with an inducible deletion system...
- Bayar Thimmapaya; Fiscal Year: 2016..is based on exciting preliminary studies showing that adenovirally-driven overexpression of Med1 (adeno-Med1) in mouse liver stimulates hepatocyte DNA replication and regeneration...
- Mechanisms of gastrointestinal cell responses to Notch SignalingTae Hee Kim; Fiscal Year: 2013..Notch signaling plays critical roles in these processes. Using powerful mouse genetic tools, I have demonstrated roles for Notch signaling and its key downstream intestine-restricted ..
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