chimpanzee

Summary

Alias: Pan troglodytes, Chimpansee troglodytes

Top Publications

  1. ncbi Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
  2. ncbi Episodic adaptive evolution of primate lysozymes
    W Messier
    Department of Biological Sciences, University at Albany, State University of New York, 12222, USA
    Nature 385:151-4. 1997
  3. ncbi Common chimpanzees have greater diversity than humans at two of the three highly polymorphic MHC class I genes
    E J Adams
    Department of Structural Biology, Stanford University School of Medicine, CA 94305 5126, USA
    Immunogenetics 51:410-24. 2000
  4. pmc Sequence variability of a human pseudogene
    R Martinez-Arias
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Genome Res 11:1071-85. 2001
  5. pmc Patterns of evolution of host proteins involved in retroviral pathogenesis
    Millan Ortiz
    Institute of Microbiology, University of Lausanne, Switzerland
    Retrovirology 3:11. 2006
  6. pmc Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein
    Nadine Laguette
    Institut de Genetique Humaine, Centre National de la Recherche Scientifique, Unité Propre de Recherche 1142, Laboratoires de Virologie Moléculaire, 34000 Montpellier, France
    Cell Host Microbe 11:205-17. 2012
  7. ncbi Diversifying selection of the tumor-growth promoter angiogenin in primate evolution
    Jianzhi Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Rm 11 N 104, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mol Biol Evol 19:438-45. 2002
  8. ncbi Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 13:1139-45. 2004
  9. ncbi Molecular evolution of microcephalin, a gene determining human brain size
    Yin Qiu Wang
    Key Laboratory of Cellulr and Molecular Evolutioin, Kunming Institute of Zoology, the Chinese Academy of Sciences CAS, Kunming, China
    Hum Mol Genet 13:1131-7. 2004
  10. ncbi Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans
    C S Hanlon
    East Anglian Regional Genetics Service, Addenbrooke s NHS Trust, Cambridge, UK
    Atherosclerosis 112:85-90. 1995

Patents

  1. THYMIC STROMAL LYMPHOPOIETIN FRAGMENTS AND USES THEREOF
  2. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
  3. NOVEL ANTIBODY SPECIFIC FOR CLEC14A AND USES THEREOF
  4. PREECLAMPSIA
  5. ANTI-GALECTIN-1 (GAL1) MONOCLONAL ANTIBODIES AND FRAGMENTS THEREOF FOR NEUTRALIZING GAL1
  6. STEM CELLS FOR TRANSPLANTATION AND MANUFACTURING METHOD THEREFOR
  7. Method for embryonic toxicity on substance
  8. Method for embryonic toxicity on substance
  9. Method of identifying eukaryotic species
  10. PREDICTIVE MARKER OF DNMT1 INHIBITOR THERAPEUTIC EFFICACY AND METHODS OF USING THE MARKER

Detail Information

Publications230 found, 100 shown here

  1. ncbi Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
    ..We sequenced the complementary DNAs that encode the FOXP2 protein in the chimpanzee, gorilla, orang-utan, rhesus macaque and mouse, and compared them with the human cDNA...
  2. ncbi Episodic adaptive evolution of primate lysozymes
    W Messier
    Department of Biological Sciences, University at Albany, State University of New York, 12222, USA
    Nature 385:151-4. 1997
    ..Both adaptive episodes were followed by episodes of negative selection. Thus this approach can detect adaptive and purifying episodes, and localize them to specific lineages during protein evolution...
  3. ncbi Common chimpanzees have greater diversity than humans at two of the three highly polymorphic MHC class I genes
    E J Adams
    Department of Structural Biology, Stanford University School of Medicine, CA 94305 5126, USA
    Immunogenetics 51:410-24. 2000
    ..having passed through a narrower population bottleneck than chimpanzees, and with pathogen-mediated selection having favored either preservation of A2 lineage alleles on the human line and/or their extinction on the chimpanzee line.
  4. pmc Sequence variability of a human pseudogene
    R Martinez-Arias
    Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Genome Res 11:1071-85. 2001
    ..glucocerebrosidase pseudogene (psGBA) for 100 human chromosomes from worldwide populations, as well as for four chimpanzee and four gorilla chromosomes...
  5. pmc Patterns of evolution of host proteins involved in retroviral pathogenesis
    Millan Ortiz
    Institute of Microbiology, University of Lausanne, Switzerland
    Retrovirology 3:11. 2006
    ....
  6. pmc Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein
    Nadine Laguette
    Institut de Genetique Humaine, Centre National de la Recherche Scientifique, Unité Propre de Recherche 1142, Laboratoires de Virologie Moléculaire, 34000 Montpellier, France
    Cell Host Microbe 11:205-17. 2012
    ..The distinct evolutionary signature of SAMHD1 sheds light on the development of its antiviral specificity...
  7. ncbi Diversifying selection of the tumor-growth promoter angiogenin in primate evolution
    Jianzhi Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Rm 11 N 104, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mol Biol Evol 19:438-45. 2002
    ..no polymorphism, which may have resulted from a recent selective sweep of a charge-altering substitution in chimpanzee evolution...
  8. ncbi Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 13:1139-45. 2004
    ..We therefore propose that genes regulating brain size during development may have the general propensity to contribute to brain evolution in primates and particularly humans...
  9. ncbi Molecular evolution of microcephalin, a gene determining human brain size
    Yin Qiu Wang
    Key Laboratory of Cellulr and Molecular Evolutioin, Kunming Institute of Zoology, the Chinese Academy of Sciences CAS, Kunming, China
    Hum Mol Genet 13:1131-7. 2004
    ..The codon-based neutrality test also indicated the signal of positive selection on five individual amino acid sites of microcephalin, which may contribute to brain enlargement during primate evolution and human origin...
  10. ncbi Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans
    C S Hanlon
    East Anglian Regional Genetics Service, Addenbrooke s NHS Trust, Cambridge, UK
    Atherosclerosis 112:85-90. 1995
    ..All were similar to apo E4. This suggests that apo E4 is the ancestral allele and that apo E2 and apo E3 arose after the split of the human and chimpanzee lineages.
  11. ncbi Prion protein gene variation among primates
    H M Schätzl
    Department of Neurology, University of California, San Francisco 94143, USA
    J Mol Biol 245:362-74. 1995
    ..Alignment of primate and other mammalian PrP sequences suggests that codons between 90 and 130 have a profound influence on the transmissibility of prions from one species to another...
  12. ncbi Rapid sequence evolution of the mammalian sex-determining gene SRY
    L S Whitfield
    Department of Genetics, Cambridge University, UK
    Nature 364:713-5. 1993
    ..The high degree of sequence divergence and the frequency of non-synonymous mutations suggest either that the majority of the coding sequence has no functional significance or that directional selection has occurred...
  13. ncbi Rapid evolution of male reproductive genes in the descent of man
    G J Wyckoff
    Committee on Genetics, University of Chicago, Illinois 60637, USA
    Nature 403:304-9. 2000
    ..evolution of male reproductive genes is observable in primates and is quite notable in the lineages to human and chimpanzee. Nevertheless, rapid evolution by itself is not necessarily an indication of positive darwinian selection; ..
  14. ncbi High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot
    A J Jeffreys
    Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
    Hum Mol Genet 9:725-33. 2000
    ....
  15. ncbi Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans
    S I Khakoo
    Department of Structural Biology, Stanford University, California 94305, USA
    Immunity 12:687-98. 2000
    ..To test this hypothesis, the structure and class I specificity of chimpanzee KIR and CD94:NKG2 receptors were determined and compared to their human counterparts...
  16. pmc Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism
    S M Fullerton
    Institute of Molecular Evolutionary Genetics, Department of Biology, and Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Am J Hum Genet 67:881-900. 2000
    ..0005+/-0.0003. Sequence analysis of the chimpanzee APOE gene showed that it was most closely related to human epsilon4-type haplotypes, differing from the human ..
  17. ncbi Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene
    ESTHER BETRAN
    Department of Ecology and Evolution, The University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
    Mol Biol Evol 19:654-63. 2002
    ..We sequenced PGAM3 in chimpanzee and macaque and obtained polymorphism data for human coding region...
  18. pmc Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees
    Natasja G de Groot
    Department of Immunobiology, Biomedical Primate Research Centre, P O Box 3306, 2280 GH, Rijswijk, The Netherlands
    Proc Natl Acad Sci U S A 99:11748-53. 2002
    ..have a natural resistance to the development of AIDS, we hypothesize that the selective sweep was caused by the chimpanzee-derived simian immunodeficiency virus (SIVcpz), the closest relative of HIV-1, or a closely related retrovirus...
  19. pmc Novel member of the CD209 (DC-SIGN) gene family in primates
    Arman A Bashirova
    Science Application International Corporation at Frederick, Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Maryland 21702, USA
    J Virol 77:217-27. 2003
    ....
  20. pmc Accelerated protein evolution and origins of human-specific features: Foxp2 as an example
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genetics 162:1825-35. 2002
    ..Using comparative analysis of human, chimpanzee, and mouse protein sequences, we identified two genes (PRM2 and FOXP2) with significantly enhanced evolutionary ..
  21. pmc Implications of natural selection in shaping 99.4% nonsynonymous DNA identity between humans and chimpanzees: enlarging genus Homo
    Derek E Wildman
    Center for Molecular Medicine and Genetics and Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Proc Natl Acad Sci U S A 100:7181-8. 2003
    ..Here we compare approximately 90 kb of coding DNA nucleotide sequence from 97 human genes to their sequenced chimpanzee counterparts and to available sequenced gorilla, orangutan, and Old World monkey counterparts, and, on a more ..
  22. ncbi Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios
    Andrew G Clark
    Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Science 302:1960-3. 2003
    Even though human and chimpanzee gene sequences are nearly 99% identical, sequence comparisons can nevertheless be highly informative in identifying biologically important changes that have occurred since our ancestral lineages diverged...
  23. ncbi Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors
    Raja Rajalingam
    Department of Structural Biology, Stanford University, 299 Campus Drive West, Stanford, CA 94305, USA
    J Immunol 172:356-69. 2004
    ..Other KIR genes represent recombinant forms present in a minority of species, often only one, as exemplified by 8 of the 11 gorilla KIR genes...
  24. pmc Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians
    Sandra Blaise
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, UMR 8122 CNRS, Institut Gustave Roussy, 94805 Villejuif, France
    J Virol 78:1050-4. 2004
    ..The functional characterization of the identified envelopes is strongly indicative of an ancestral retrovirus infection and endogenization, with some of the envelope functions subsequently retained in evolution...
  25. pmc Evolution of the human ASPM gene, a major determinant of brain size
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genetics 165:2063-70. 2003
    ....
  26. ncbi Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans
    Patrick D Evans
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 13:489-94. 2004
    ..Additionally, the lineage from the last human/chimpanzee ancestor to humans shows an excess of non-synonymous over synonymous substitutions, which is a signature of ..
  27. ncbi Meat-adaptive genes and the evolution of slower aging in humans
    Caleb E Finch
    Andrus Gerontology Center, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    Q Rev Biol 79:3-50. 2004
    The chimpanzee life span is shorter than that of humans, which is consistent with a faster schedule of aging...
  28. ncbi DNA sequence and comparative analysis of chimpanzee chromosome 22
    H Watanabe
    RIKEN, Genomic Sciences Center, Yokohama 230 0045, Japan
    Nature 429:382-8. 2004
    Human-chimpanzee comparative genome research is essential for narrowing down genetic changes involved in the acquisition of unique human features, such as highly developed cognitive functions, bipedalism or the use of complex language...
  29. ncbi Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation
    Bertrand Bonnaud
    UMR 2714 CNRS bioMérieux IFR128 BioSciences Lyon Gerland, Ecole Normale Superieure de Lyon, Lyon, France
    Mol Biol Evol 21:1895-901. 2004
    ..substitutions and indels was analyzed within all human HERV-W elements and along the ERVWE1 orthologous loci in chimpanzee, gorilla, orangutan, and gibbon...
  30. pmc Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 2:E275. 2004
    ..Despite being only recently discovered, editing of RNA and DNA may thus represent an ancient form of host defense in primate genomes...
  31. pmc Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms
    Takashi Angata
    Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093 0687, USA
    Proc Natl Acad Sci U S A 101:13251-6. 2004
    ..Nonsynonymous differences between human and chimpanzee orthologs showed uneven distribution between the two beta sheets of the Sia-recognition domain, suggesting ..
  32. ncbi Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predisposition
    Adam Pavlicek
    Genetic Information Research Institute, Mountain View, CA, USA
    Hum Mol Genet 13:2737-51. 2004
    ..Previously, a rapidly evolving region with evidence of positive evolutionary selection in human and chimpanzee had been identified only in exon 11...
  33. pmc Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:2832-7. 2005
    ..Our study highlights the power of evolutionary analyses, in which positive selection identifies not only the age of genetic conflict but also the interaction interface where this conflict plays out...
  34. ncbi Reduced MIC gene repertoire variation in West African chimpanzees as compared to humans
    Natasja G de Groot
    Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Mol Biol Evol 22:1375-85. 2005
    ..The present population study illustrates that all chimpanzee haplotypes sampled possess the hybrid MICA/B gene...
  35. pmc Retrovirus restriction by TRIM5alpha variants from Old World and New World primates
    Byeongwoon Song
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA, USA
    J Virol 79:3930-7. 2005
    ..b>Chimpanzee and orangutan TRIM5alpha proteins functionally resembled human TRIM5alpha, potently restricting infection by N-..
  36. pmc The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates
    Byeongwoon Song
    Dana Farber Cancer Institute, 44 Binney Street, JFB 824, Boston, MA 02115, USA
    J Virol 79:6111-21. 2005
    ..The results are consistent with a role for TRIM5alpha in innate immunity against retroviruses...
  37. pmc The complexity of selection at the major primate beta-defensin locus
    Colin A M Semple
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK
    BMC Evol Biol 5:32. 2005
    ..We have used a combination of maximum likelihood based tests and a maximum parsimony based sliding window approach to give a detailed view of the varying modes of selection operating at this locus...
  38. pmc Comprehensive search for intra- and inter-specific sequence polymorphisms among coding envelope genes of retroviral origin found in the human genome: genes and pseudogenes
    Nathalie de Parseval
    UMR 8122 CNRS, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    BMC Genomics 6:117. 2005
    ..Several of them are conserved during primate evolution, having possibly been co-opted by their host for a physiological role...
  39. pmc Emergence of young human genes after a burst of retroposition in primates
    Ana Claudia Marques
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Biol 3:e357. 2005
    ....
  40. ncbi High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Curr Biol 16:95-100. 2006
    ..The unexpectedly high frequency of an impaired retroviral restriction allele among humans is likely to have a significant impact on our ability to ward off future retroviral challenges...
  41. pmc Evolution of the NANOG pseudogene family in the human and chimpanzee genomes
    Daniel J Fairbanks
    Department of Plant and Animal Sciences, Brigham Young University, Provo, UT 84602, USA
    BMC Evol Biol 6:12. 2006
    ..This article compares the NANOG gene and its pseudogenes in the human and chimpanzee genomes and derives an evolutionary history of this pseudogene family.
  42. pmc All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction
    Sadayuki Ohkura
    Division of Virology, National Institute for Medical Research, Medical Research Council, London, UK
    J Virol 80:8554-65. 2006
    ..2 core structure. It is hypothesized that these three loops form a binding surface for virus and that evolutionary changes in any one of the loops can alter restriction specificity...
  43. pmc Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution
    Joe Gasper
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 79:820-30. 2006
    ..Finally, we observe adaptive evolution in haplotypes segregating for a frameshift mutation that was previously thought to indicate that ZAN was a potential pseudogene...
  44. pmc Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution
    Anders L Kjeldbjerg
    Department of Molecular Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    BMC Evol Biol 8:266. 2008
    ..However, a few intact and very old HERV genes exist, and likely are beneficial for the host. We here address evolutionary aspects of two HERV-V envelope genes, ENVV1 and ENVV2, located in tandem and containing a long open reading frame...
  45. pmc The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus
    Abraham L Brass
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA
    Cell 139:1243-54. 2009
    ..Collectively this work identifies a family of antiviral restriction factors that mediate cellular innate immunity to at least three major human pathogens...
  46. pmc Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses
    Efrem S Lim
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, P O Box 10924, Seattle, WA 98109 1024, USA
    J Virol 84:7124-34. 2010
    ..Our combined evolutionary and functional studies have allowed us to reconstruct the host-pathogen interactions that have shaped Tetherin and its lentivirus-encoded antagonists...
  47. doi Diversification of bitter taste receptor gene family in western chimpanzees
    Tohru Sugawara
    Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan
    Mol Biol Evol 28:921-31. 2011
    ..Here, we investigated the sequences of all 28 putative functional chimpanzee T2R genes (cT2Rs) in 46 western chimpanzees to compare the intraspecies variations in chimpanzees to those ..
  48. pmc The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx
    Efrem S Lim
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Cell Host Microbe 11:194-204. 2012
    ..We conclude that vpr neofunctionalized to degrade SAMHD1 even prior to the birth of a separate vpx gene, thereby initiating an evolutionary arms race with SAMHD1...
  49. pmc A polymorphic indel containing the RS3 microsatellite in the 5' flanking region of the vasopressin V1a receptor gene is associated with chimpanzee (Pan troglodytes) personality
    W D Hopkins
    Neuroscience Institute and Language Research Center, Georgia State University, Atlanta, 30302, USA
    Genes Brain Behav 11:552-8. 2012
    ..same 5' flanking region of the AVPR1A on subjective ratings of personality in a sample of 83 chimpanzees (Pan troglodytes)...
  50. pmc Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor
    Chiyu Zhang
    Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, China
    PLoS ONE 7:e37477. 2012
    ..HIV type 1 (HIV-1) and type 2 (HIV-2) were derived from SIVs that infected chimpanzee (SIVcpz) and sooty mangabey (SIVsm), respectively...
  51. ncbi Interferon-inducible gene expression in chimpanzee liver infected with hepatitis C virus
    T Kato
    Medical Research Institute, Nihon University School of Medicine, Tokyo, Japan
    Virology 190:856-60. 1992
    ..C virus (HCV) infection was examined by isolation of HCV-induced genes from a cDNA library constructed from chimpanzee liver during the acute phase of hepatitis C...
  52. pmc Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution
    Sandra Blaise
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de la Recherche Scientifique, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Proc Natl Acad Sci U S A 100:13013-8. 2003
    ....
  53. pmc The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology
    Francois Mallet
    Unité Mixte de Recherche 2142, Centre National de la Recherche Scientifique bioMérieux, IFR128 Biosciences Lyon Gerland, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Proc Natl Acad Sci U S A 101:1731-6. 2004
    ..Such functions were also shown to be preserved in the orthologous loci isolated from chimpanzee, gorilla, orangutan, and gibbon...
  54. ncbi Expansion and divergence of the GH locus between spider monkey and chimpanzee
    Agnès Revol de Mendoza
    Laboratorio de Biologia Molecular, Unidad de Laboratorios de Ingeniería y Expresión Genéticas, Departamento de Bioquimica, Facultad de Medicina, UANL, Av Madero y Dr A Pequeño, Col Mitras Centro, Monterrey CP64460, Mexico
    Gene 336:185-93. 2004
    ..comprising the GH loci of the spider monkey (Ateles geoffroyi), a New-World primate, and of the chimpanzee (Pan troglodytes), an ape...
  55. ncbi Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux
    Fabien Burki
    Center for Integrative Genomics, University of Lausanne, BEP, 1015 Lausanne, Switzerland
    Nat Genet 36:1061-3. 2004
    ..The amino acid changes responsible for the unique brain-specific properties of the enzyme derived from GLUD2 occurred during a period of positive selection after the duplication event...
  56. ncbi Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee
    Jennifer F Hughes
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 437:100-3. 2005
    ..Here we find, by systematically comparing the DNA sequences of unique, Y-linked genes in chimpanzee and human, which diverged about six million years ago, evidence that in the human lineage, all such genes were ..
  57. pmc Pervasive adaptive evolution in primate seminal proteins
    Nathaniel L Clark
    Department of Genome Sciences, University of Washington, Seattle, Washington, USA
    PLoS Genet 1:e35. 2005
    ..selection when comparing 161 human seminal fluid proteins and 2,858 prostate-expressed genes to those in chimpanzee. Seven of eight outstanding genes yielded statistically significant evidence of positive selection when analyzed ..
  58. ncbi The gene of retroviral origin Syncytin 1 is specific to hominoids and is inactive in Old World monkeys
    Mario Cáceres
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA 30322, USA
    J Hered 97:100-6. 2006
    ..Our results indicate that Syncytin 1 is indeed a hominoid-specific gene and illustrate the complex and dynamic process associated with the origin of new genes...
  59. pmc Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation
    Paula C Soto
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 184:4185-95. 2010
    ..In this study, we show that human T cells are more reactive than chimpanzee T cells to a wide variety of stimuli, including anti-TCR Abs of multiple isotypes, l-phytohemagglutin, ..
  60. ncbi A major histocompatibility complex class I allele shared by two species of chimpanzee
    S Cooper
    Department of Structural Biology, Sherman Fairchild Building, Stanford University School of Medicine, Stanford, CA 94305 5400, USA
    Immunogenetics 47:212-7. 1998
    ..Discovery of identical [1101 base pairs (bp)] coding regions at the MHC class I C locus in Pan troglodytes and Pan paniscus, chimpanzee species that diverged approximately 2...
  61. ncbi Human type I hair keratin pseudogene phihHaA has functional orthologs in the chimpanzee and gorilla: evidence for recent inactivation of the human gene after the Pan-Homo divergence
    H Winter
    German Cancer Research Center, Heidelberg, Germany
    Hum Genet 108:37-42. 2001
    ..Large-scale genotyping of human, chimpanzee, and gorilla DNAs revealed the homozygous presence of the phihHaA nonsense mutation in humans of different ..
  62. ncbi Beta-defensin 1 gene variability among non-human primates
    Massimiliano Del Pero
    Dipartimento di Biologia Animale e dell Uomo, Universita di Torino, Via Accademia Albertina 13 17, 10123 Turin, Italy
    Immunogenetics 53:907-13. 2002
    ..Compared with these taxa, hylobatids and cercopithecids exhibit 3-4 amino acid substitutions, some of which increase the net charge of the active molecule...
  63. ncbi Search for genes positively selected during primate evolution by 5'-end-sequence screening of cynomolgus monkey cDNAs
    Naoki Osada
    Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo
    Genomics 79:657-62. 2002
    ..The products of other candidate genes consisted of a cell-surface protein, a member of the lipocalin family, a nuclear transcription factor, and hypothetical proteins...
  64. ncbi Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis
    P Jeremy Wang
    Howard Hughes Medical Institute, Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Hum Mol Genet 11:2341-6. 2002
    ..The observation that TAF1L can functionally replace TAF(II)250 provides experimental support for the hypothesis that during male meiosis, autosomes provide cellular functions usually supplied by the X chromosome in somatic cells...
  65. pmc Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates
    Jianzhi Zhang
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:8337-41. 2003
    ....
  66. ncbi Conservation and loss of the ERV3 open reading frame in primates
    C A Herve
    The Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, London W6 8LH, UK
    Genomics 83:940-3. 2004
    ..In the chimpanzee, the protein sequence of Env is 98.18% identical to that of human. In other species the identity falls (93...
  67. ncbi Orthologous numbering of great ape and human chromosomes is essential for comparative genomics
    E H McConkey
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Cytogenet Genome Res 105:157-8. 2004
  68. ncbi Positive selection in MAOA gene is human exclusive: determination of the putative amino acid change selected in the human lineage
    Aida M Andres
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain
    Hum Genet 115:377-86. 2004
    ..a population genetic analysis of the pattern of nucleotide variation in non-human species, including bonobo, chimpanzee, gorilla, and orangutan...
  69. ncbi Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity
    Steve Dorus
    Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Nat Genet 36:1326-9. 2004
    ..Our study showcases the intimate relationship between sexual selection and the molecular evolution of reproductive genes...
  70. ncbi Molecular evolution of growth hormone gene family in old world monkeys and hominoids
    Chun Ye
    Laboratory of Cellular and Molecular Evolution, and Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
    Gene 350:183-92. 2005
    ..Our results disclosed the complex history of the primate growth hormone gene family and raised intriguing questions on the consequences of these evolutionary events...
  71. ncbi Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity
    Igor Zelezetsky
    Department of Biochemistry, University of Trieste, Trieste, I 34127, Italy
    J Biol Chem 281:19861-71. 2006
    ..The evolution of these peptides has thus resulted in distinct mechanisms of action that affect the direct antimicrobial activity and may also modulate accessory antimicrobial functions due to interactions with host cells...
  72. pmc The evolution and genomic landscape of CGB1 and CGB2 genes
    Pille Hallast
    Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia
    Mol Cell Endocrinol 260:2-11. 2007
    ..While the function of these genes is not yet known, they are strongly conserved between human and chimpanzee and exhibit three-fold lower diversity than LHB across human populations with no mutations that would disrupt ..
  73. pmc Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Pathog 3:e197. 2007
    ..Astonishingly, this same loop is under positive selection in the multiple cow TRIM5 genes as well, indicating that this small structural loop may be a viral recognition motif spanning a hundred million years of mammalian evolution...
  74. ncbi Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes
    R R Freimuth
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Graduate School Mayo Clinic, Rochester, MN, USA
    Pharmacogenomics J 4:54-65. 2004
    ..SULT6B1 was also present in chimpanzee and gorilla, differing at only seven encoded amino-acid residues among the three species...
  75. doi Effect of species-specificity in auditory-visual intermodal matching in a chimpanzee (Pan troglodytes) and humans
    L Martinez
    Department of Brain and Behavioral Sciences, Primate Research Institute, Kyoto University, Kanrin 41 2, Inuyama, Aichi 484 8506, Japan
    Behav Processes 82:160-3. 2009
    The goal of this study was to compare the performance of a chimpanzee and humans on auditory-visual intermodal matching of conspecifics and non-conspecifics...
  76. ncbi Foramen magnum position variation in Pan troglodytes, Plio-Pleistocene hominids, and recent Homo sapiens: implications for recognizing the earliest hominids
    James C M Ahern
    Department of Anthropology, University of Wyoming, Laramie, Wyoming 82071, USA
    Am J Phys Anthropol 127:267-76. 2005
    ..examined whether or not the positions of biporion and bicarotid relative to basion sufficiently distinguished Pan troglodytes from recent Homo sapiens and Plio-Pleistocene hominids...
  77. ncbi Comparing maternal styles in bonobos (Pan paniscus) and chimpanzees (Pan troglodytes)
    Mieke De Lathouwers
    Department of Biology, University of Antwerp, Antwerp, Belgium
    Am J Primatol 64:411-23. 2004
    ..maternal styles in Cercopithecine species can be applied to bonobos (Pan paniscus) and chimpanzees (Pan troglodytes), 2) determine whether they follow the same pattern, and 3) assess whether species differences in maternal ..
  78. doi How the great apes (Pan troglodytes, Pongo pygmaeus, Pan paniscus, Gorilla gorilla) perform on the reversed reward contingency task II: transfer to new quantities, long-term retention, and the impact of quantity ratios
    Jana Uher
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    J Comp Psychol 122:204-12. 2008
    We tested 6 chimpanzees (Pan troglodytes), 3 orangutans (Pongo pygmaeus), 4 bonobos (Pan paniscus), and 2 gorillas (Gorilla gorilla) in the reversed reward contingency task...
  79. ncbi The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application
    Harvey Wong
    Discovery Metabolism and Pharmacokinetics, Bristol Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492 7660, USA
    Drug Metab Dispos 32:1359-69. 2004
    The chimpanzee (CHP) was evaluated as a pharmacokinetic model for humans (HUMs) using propranolol, verapamil, theophylline, and 12 proprietary compounds...
  80. ncbi Histologic examination of bone development in juvenile chimpanzees
    Dawn M Mulhern
    Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560, USA
    Am J Phys Anthropol 122:127-33. 2003
    The purpose of this study is to determine whether histologic skeletal development in chimpanzees (Pan troglodytes) differs from that in humans. Currently, minimal quantitative data are available on the bone histology of great apes...
  81. ncbi Genetic diversity and phylogeographic clustering of SIVcpzPtt in wild chimpanzees in Cameroon
    Fran Van Heuverswyn
    UMR145, Institut de Recherche pour le Developpement, Department of International Health, University of Montpellier 1, 911, Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
    Virology 368:155-71. 2007
    ..that the clade of simian immunodeficiency viruses (SIVs) infecting west central African chimpanzees (Pan troglodytes troglodytes) and western gorillas (Gorilla gorilla gorilla) comprises the progenitors of human ..
  82. ncbi Dimensions and moment arms of the hind- and forelimb muscles of common chimpanzees (Pan troglodytes)
    S K Thorpe
    Department of Human Anatomy and Cell Biology, New Medical School, University of Liverpool, Liverpool, L69 3GE United Kingdom
    Am J Phys Anthropol 110:179-99. 1999
    This paper supplies quantitative data on the hind- and forelimb musculature of common chimpanzees (Pan troglodytes) and calculates maximum joint moments of force as a contribution to a better understanding of the differences between ..
  83. ncbi Patterns of mandibular variation in Pan and Gorilla and implications for African ape taxonomy
    Andrea B Taylor
    Department of Community and Family Medicine, Duke University Medical Center, Box 3907, Durham, NC 27710, USA
    J Hum Evol 44:529-61. 2003
    ..Specifically, we evaluate the purported distinctiveness of P.t. verus from the other two subspecies of Pan troglodytes, and the recent proposals to recognize Nigerian gorillas as a distinct subspecies, Gorilla gorilla diehli, ..
  84. doi Chaînes opératoires and resource-exploitation strategies in chimpanzee (Pan troglodytes) nut cracking
    Susana Carvalho
    Department of Anthropology, Faculty of Sciences and Technology, University of Coimbra, Rua do Arco da Traição, 56, 3000 056 Coimbra, Portugal
    J Hum Evol 55:148-63. 2008
    ..We focused on the detection of operational sequences by wild chimpanzees (Pan troglodytes verus) when nut cracking with lithic implements at the sites of Bossou and Diecké, Guinea, West Africa...
  85. doi Paternity and social rank in wild chimpanzees (Pan troglodytes) from the Budongo Forest, Uganda
    Nicholas E Newton-Fisher
    School of Anthropology and Conservation, University of Kent, Canterbury, Kent, UK
    Am J Phys Anthropol 142:417-28. 2010
    ..patterns of paternity and male dominance rank in the Sonso community of wild East African chimpanzees (Pan troglodytes schweinfurthii) in the Budongo Forest, Uganda...
  86. doi Metacarpal trabecular architecture variation in the chimpanzee (Pan troglodytes): Evidence for locomotion and tool-use?
    Richard A Lazenby
    University of Northern British Columbia, Prince George, BC, Canada V2N4Z9
    Am J Phys Anthropol 144:215-25. 2011
    ..Two subspecies, West African Pan troglodytes verus from the Taï Forest, Côte d'Ivoire (n = 12) and Central African P. t...
  87. ncbi Use of intrauterine devices (IUDs) for contraception in the common chimpanzee (Pan troglodytes)
    K G Gould
    Yerkes Regional Primate Research Center of Emory University, Atlanta, GA 30322, USA
    J Med Primatol 29:63-9. 2000
    The common chimpanzee (Pan troglodytes) is a species phylogenetically very close to man. It was not many years ago that the captive population of chimpanzees (P...
  88. ncbi Fifty years of chimpanzee demography at Taronga Park Zoo
    Judith Littleton
    Department of Anthropology, University of Auckland, Auckland, New Zealand
    Am J Primatol 67:281-98. 2005
    There has been a captive Pan troglodytes colony at Taronga Park Zoo in Sydney, Australia, since the mid-1930s...
  89. ncbi Measurement of eye-gaze in chimpanzees (Pan troglodytes)
    Emily J Bethell
    Department of Psychology, University of Portsmouth, Hampshire, UK
    Am J Primatol 69:562-75. 2007
    ..This study presents the first documentation of the surface eye movements of the chimpanzee, Pan troglodytes, in order to determine the behavioral forms of eye-gaze and their saliency as signals, document their ..
  90. ncbi Chimpanzee grouping patterns and food availability in Mahale Mountains National Park, Tanzania
    Noriko Itoh
    Cultural, Regional and Historic Studies on the Environment Cultural Anthropology, Department of Studies in Human Coexistence, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan
    Primates 48:87-96. 2007
    ..was to test for a correlation between party size and food (fruit) availability among the M group chimpanzees (Pan troglodytes) in the Mahale Mountains, Tanzania...
  91. ncbi Nonlinear acoustics in the pant hoots of common chimpanzees (Pan troglodytes): vocalizing at the edge
    Tobias Riede
    National Center for Voice and Speech, Denver Center for the Performing Arts, CO 80204, USA
    J Acoust Soc Am 121:1758-67. 2007
    Common chimpanzee (Pan troglodytes) "pant hoots" are multi-call events that build from quiet, consistently harmonic introductory sounds to loud, screamlike "climax" calls with acoustic irregularities known as "nonlinear phenomena" (NLP)...
  92. doi The nature of culture: technological variation in chimpanzee predation on army ants revisited
    Caspar Schoning
    Institute of Biology, Department of Population Biology, University of Copenhagen, Copenhagen 2100, Denmark
    J Hum Evol 55:48-59. 2008
    Chimpanzee (Pan troglodytes) predation on army ants (Dorylus, subgenus Anomma) is an impressive example of skillful use of elementary technology, and it has been suggested to reflect cultural differences among chimpanzee communities...
  93. pmc Menstrual cycles continue into advanced old age in the common chimpanzee (Pan troglodytes)
    AGNES LACREUSE
    Department of Psychology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Biol Reprod 79:407-12. 2008
    ..long-held consensus among reproductive scientists has been that our closest living relative, the chimpanzee (Pan troglodytes), experiences menstrual cycles until death...
  94. pmc Comparative microanatomy of the orbicularis oris muscle between chimpanzees and humans: evolutionary divergence of lip function
    Carolyn R Rogers
    Division of Plastic Surgery, Department of Surgery, School of Medicine, University of Wisconsin Hospital and Clinics, USA
    J Anat 214:36-44. 2009
    ..As the chimpanzee (Pan troglodytes) is the closest living relative of humans, a comparison of the orbicularis oris muscle between these species ..
  95. pmc Evidence from Cameroon reveals differences in the genetic structure and histories of chimpanzee populations
    Mary Katherine Gonder
    Department of Biological Sciences, University at Albany State University of New York, Albany, NY 12222, USA
    Proc Natl Acad Sci U S A 108:4766-71. 2011
    The history of the genus Pan is a topic of enduring interest. Chimpanzees (Pan troglodytes) are often divided into subspecies, but the population structure and genetic history of chimpanzees across Africa remain unclear...
  96. doi Chimpanzee (Pan troglodytes) and orangutan (Pongo abelii) forethought: self-control and pre-experience in the face of future tool use
    Mathias Osvath
    Lunds University Cognitive Science, Lund, Sweden
    Anim Cogn 11:661-74. 2008
    ..In a series of four experiments based on tool use, we demonstrate that chimpanzees (Pan troglodytes) and orangutans (Pongo abelii) override immediate drives in favor of future needs, and they do not merely ..
  97. ncbi Normal vaginal flora in chimpanzees (Pan troglodytes): qualitative and quantitative study
    Kazuhiro Noguchi
    Division of Microbiology and Genetics, Center for Animal Resources and Development, Institute of Resource Development and Analysis, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Comp Med 54:705-12. 2004
    ..To clarify our speculation, we examined the development of the vaginal flora in chimpanzees (Pan troglodytes)...
  98. ncbi The geographic apportionment of mitochondrial genetic diversity in east African chimpanzees, Pan troglodytes schweinfurthii
    T L Goldberg
    Harvard University, Department of Anthropology, USA
    Mol Biol Evol 14:976-84. 1997
    This study is a geographically systematic genetic survey of the easternmost subspecies of chimpanzee, Pan troglodytes schweinfurthii...
  99. ncbi Reproductive endocrinology of wild female chimpanzees (Pan troglodytes schweinfurthii): methodological considerations and the role of hormones in sex and conception
    Melissa Emery Thompson
    Department of Anthropology, Harvard University, Cambridge, Massachusetts 02138, USA
    Am J Primatol 67:137-58. 2005
    Fecal and urine samples were collected from 81 female East African chimpanzees (Pan troglodytes schweinfurthii) in three major study populations in Gombe National Park, Tanzania, and Budongo Forest Reserve and Kibale National Park, ..
  100. pmc A cross-setting study of chimpanzee (Pan troglodytes) personality structure and development: zoological parks and Yerkes National Primate Research Center
    Alexander Weiss
    Department of Psychology, The University of Edinburgh, Edinburgh, UK
    Am J Primatol 69:1264-77. 2007
    ..These findings suggest that, whereas there may be differences in the ease with which ratings are made, personality structure, and development are largely consistent across widely differing settings...
  101. ncbi Chimpanzee (Pan troglodytes) anticipation of food return: coping with waiting time in an exchange task
    V Dufour
    Ethology Research, Animal Science Department, Biomedical Primate Research Centre, Rijswijk, Netherlands
    J Comp Psychol 121:145-55. 2007
    ..The authors investigated the abilities of 5 chimpanzees (Pan troglodytes) to cope with increasing waiting duration in exchange tasks...

Research Grants64

  1. Studying the evolution of gene regulation at the protein level in primates
    GEORGE HERBERT PERRY; Fiscal Year: 2010
    ..expression levels in multiple primate species, (ii) use this platform for comparisons of human, chimpanzee (Pan troglodytes), and rhesus macaque (Macaca mulatta) liver, kidney, heart, lung and testis tissues, and (iii) examine ratios ..
  2. ESTABLISHMENT/MAINTENANCE OF BIOMEDICAL RESEARCH COLONY
    Thomas J Rowell; Fiscal Year: 2011
    ..The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model...
  3. ENDOCRINOLOGY AND BEHAVIOR
    MIKE JURKE; Fiscal Year: 1999
    ..in the literature on social and reproductive behavior of our closest relatives: the common chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus)...
  4. Chimpanzee Biomedical Research Program Limited Competition (U42)
    M Babette Fontenot; Fiscal Year: 2013
    ..The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model...
  5. The MHC of wild chimpanzees: genetic variation, disease and reproductive success
    EMILY ELIZABETH WROBLEWSKI; Fiscal Year: 2012
    ..The study will 1) Characterize the MHC genetic variation in the chimpanzee population (Pan troglodytes schweinfurthii) at Gombe National Park, Tanzania;2) Examine the correlation between MHC genotype and health ..
  6. Evolution and Ancestral Functions of a Human MHC Class I Pseudogene, HLA-Y
    ANA S GOYOS; Fiscal Year: 2012
    ..class I gene in chimpanzee named Patr-AL because it was most like MHC-A and was identified in the chimpanzee (Pan troglodytes A-like)...
  7. Macrostructural and Microstructural Analysis of the Primate Corpus Callosum
    KIMBERLEY ANN PHILLIPS; Fiscal Year: 2010
    ..In this application, we will examine the topography of the CC in two divergent primate species - chimpanzees (Pan troglodytes) and capuchin monkeys (Cebus apella) - that have independently evolved several behavioral and anatomical ..
  8. Conference Support: NHP Models of Aging
    Joseph Kemnitz; Fiscal Year: 2001
    ..Saimiri sciureus), cynomolgus monkeys (Macaca fascicularis), baboons (Papio hamadryas), and chimpanzees (Pan troglodytes). A working dinner will be held on the evening of May 31...
  9. ESTABLISHMENT OF A CHIMPANZEE BREEDING/RESEARCH PROGRAM
    Thomas Rowell; Fiscal Year: 2000
    Biomedical and behavioral scientists consider the chimpanzee (Pan troglodytes) essential to investigations directed at important human health problems because the chimpanzee and human share evolutionary similarities in immune system, ..
  10. CHIMERIC VIRUS PRIMATE MODEL OF HEPATITIS C
    STANLEY LEMON; Fiscal Year: 2005
    ..The chimpanzee (Pan troglodytes) is the only animal species permissive for infection with this virus...
  11. EXPANSION OF CHIMPANZEE HOLDING FACILITIES
    Thomas Rowell; Fiscal Year: 1999
    ..of Southwestern Louisiana New Iberia Research Center (USL-NIRC) currently maintains 246 chimpanzees (Pan troglodytes) through support by the National Institute of Neurological Diseases and Strokes and the National Center for ..
  12. HCV SPECIFIC T CELL RESPONSES
    Christopher Walker; Fiscal Year: 2003
    ..The common chimpanzee (Pan troglodytes) is the only animal model for studying mechanisms of protective immunity against HCV...
  13. Beatrice H Hahn; Fiscal Year: 2016
    ..While the origins of H|V-1 groups M and N have been traced to distinct chimpanzee communities in southern Cameroon, the precursors of HIV-1 groups O and P are still uncertain...
  14. Y CHROMOSOME EVOLUTION AND MODERN HUMAN ORIGINS
    Michael Hammer; Fiscal Year: 1999
    ..five kilobases of Y-specific single-copy DNA will be sequenced from 16 humans and four species of great apes (Pan troglodytes, Pan paniscus, Gorilla gorilla, and Pongo pygmaeus)...
  15. Molecular Epidemiology and Natural History of SIVcpz
    Beatrice H Hahn; Fiscal Year: 2013
    ..We also traced the origin of pandemic and non-pandemic HIV-1 to distinct chimpanzee communities in southern Cameroon (Science 2006), discovered HIV-1 group O-like viruses in wild gorillas (Nature ..
  16. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    ..In this context we studied Patr-AL, a novel and chimpanzee-specific MHC class I that is encoded by a novel, non- polymorphic gene, with distinctive tissue distribution, ..
  17. Beatrice H Hahn; Fiscal Year: 2016
    ..falciparum is of gorilla origin, and not of chimpanzee, bonobo or ancient human origin...
  18. Genetic and Developmental Mechanisms of Evolutionary Innovations
    Artyom Kopp; Fiscal Year: 2012
    ..Understanding how and why these innovations evolved is a central motivation for sequencing the chimpanzee and other primate genomes...
  19. A Therapeutic Vaccine for EBV-Associated Malignancies
    Paul M Lieberman; Fiscal Year: 2010
    ..The vaccine vector will be derived from the E1-deleted adenoviral vectors based on the chimpanzee-serotype 68 (AdC68) to eliminate background immunogenicity to more common human serotypes...
  20. James P Noonan; Fiscal Year: 2016
    ..developmental enhancer that has gained a robust limb expression domain relative to the orthologous elements from chimpanzee and rhesus macaque. This domain includes the presumptive anterior wrist and proximal thumb...
  21. Peter J Hornsby; Fiscal Year: 2014
    ..Among nonhuman primates, the chimpanzee occupies a unique position for comparative biology...
  22. Vaccination with purified, cryopreserved, infectious Plasmodium vivax sporozoites
    STEPHEN LEV HOFFMAN; Fiscal Year: 2013
    ..vivax (Pv) sporozoites (SPZ) in the world, and showed that these cryopreserved PvSPZ can be used to infect a chimpanzee and to infect hepatocytes in vitro, Sanaria is now poised to use these infectious PvSPZ as a first- ever whole ..
  23. Yoav Gilad; Fiscal Year: 2014
    ..data, methylation state, and histone modification profiles from a set of five tissues from multiple human, chimpanzee, and rhesus macaque individuals...
  24. Molecular epidemiology of Plasmodium reichenowi
    Julian Rayner; Fiscal Year: 2009
    ..generated using these frozen stocks, it consists largely of short fragments and is heavily contaminated with chimpanzee DNA. Work on the P. reichenowi genome has ceased until new sources of P. reichenowi DNA can be found. New P...
  25. COGNITIVE AND MOTORIC AGING
    James G Herndon; Fiscal Year: 2011
    ..in humans and two nonhuman primates with distinct life histories and adaptations, the rhesus monkey and the chimpanzee, could yield important clues to the uniquely human predisposition to neurodegenerative diseases and the aging ..
  26. Nuclear integrations of mitochondrial DNA in great apes
    Nicola Anthony; Fiscal Year: 2007
    ..First, the strategy is (1) to screen Numts from chimpanzee and gorilla BAC libraries for nuclear insertions, as well as to search nuclear-enriched DNA phage libraries from ..
  27. DAVD C VAN ESSEN; Fiscal Year: 2016
    ..We will compare the functional organization of human cerebral cortex to that in the chimpanzee and macaque monkey...
  28. Innovative AIDS Research Housing for Nonhuman Primates
    Stuart Zola; Fiscal Year: 2013
    ..monkeys by renovating a building that previously housed chimpanzees (those animals were retired to the National Chimpanzee Sanctuary)...
  29. Stefan Worgall; Fiscal Year: 2016
    ..aeruginosa OprF protein. Our prior studies established that, the chimpanzee-based Ad vector (AdC7) expressing OprF and a peptide motif (RGD) that enhances infection of immune cells ..
  30. William D Hopkins; Fiscal Year: 2015
    ..function and neurotransmission within BA44, BA45, BA22, BA4, BA41/42 and BA17 will also be quantified in the chimpanzee post-mortem tissue...
  31. Robert W Gracy; Fiscal Year: 2016
    ..population of nonhuman primates available for genetic research;broad research opportunities with the largest chimpanzee population at any National Primate Research Center;ABSL-3 and ABSL-4 facilities;research emphasis and expertise ..
  32. Studies of chimpanzee spatial cognition and foraging
    Charles R Menzel; Fiscal Year: 2010
    ..Specific Aim 2 is to determine which of these different types of information a chimpanzee can recall and convey about a past event at a single reporting session...
  33. EMANUEL HEY; Fiscal Year: 2016
    ..These new methods will be applied to a case study of divergence among species and subspecies of Chimpanzee. The methods will also be applied to large multi-population multi-locus data sets from human populations...
  34. Detect small and very small in-space inversions and improve alignment quality
    Minmei Hou; Fiscal Year: 2010
    ..The big discrepancy of previous results on small inversions between human and chimpanzee indicates that detecting small inversions is very difficult even for closely related species...
  35. Leslie A Real; Fiscal Year: 2014
    ..hosts, calibrated against geo-referenced molecular sequence data from both human and candidate host (Gorilla, chimpanzee, bat) infections...
  36. Hepatitis C: Studies of Immunity and Pathogenesis
    Charles Rice; Fiscal Year: 2009
    ..Prior to testing in mouse and chimpanzee models of HCV infection, he will work with Dr. Rice to evaluate their anti-HCV efficacy in cell culture. Dr...
  37. CALCULATED RECIPROCITY IN CHIMPANZEES
    Frans De Waal; Fiscal Year: 1993
    ..A previous study of captive chimpanzees (Pan troglodytes) suggested food- sharing as a promising dependent variable in this species...
  38. Regulatory architecture of the Androgen Receptor locus in development & evolution
    Philip L Reno; Fiscal Year: 2010
    ..flanking regions of the AR gene, which removes non-coding sequences that are otherwise highly conserved in the chimpanzee, rhesus, dog, and mouse...
  39. Stanley M Lemon; Fiscal Year: 2016
    ..Recent chimpanzee studies have validated miR-122 silencing as an effective antiviral strategy, yet how miR-122 promotes HCV ..
  40. JYOTSNA S SHAH; Fiscal Year: 2014
    ..falciparum, P. vivax and P. malariae;from chimpanzee blood with P. ovale. (4) Clinical Trials - 4a: Training and competency of Clinical Sites to perform assay...
  41. Investigating CpG islands in mammalian genomes
    Zhongming Zhao; Fiscal Year: 2010
    ..will first perform a comprehensive survey of the distribution of CpG islands in five mammalian genomes (human, chimpanzee, mouse, rat, and dog) and their genomic regions...
  42. NIH-OWNED CHIMPANZEE RESEARCH RESOURCE AT THE SNPRC
    John L Vandeberg; Fiscal Year: 2011
    ..Via fulfilling these aims, we will establish a chimpanzee resource that is unique among all chimpanzee research resources in enabling investigators for the first time to ..
  43. What Made Us Human?
    KATHERINE SNOWDEN POLLARD; Fiscal Year: 2011
    ..Mounting evidence suggests that the vast majority of functional differences between the human and chimpanzee genomes are in regions that do not code for proteins...
  44. Robert E Lanford; Fiscal Year: 2015
    ..Via fulfilling these aims, we will establish a chimpanzee resource that is unique among all chimpanzee research resources in enabling investigators for the first time to ..
  45. How Maternal Stress Influences Offspring Health &Development in Wild Chimpanzees
    CARSON MURRAY; Fiscal Year: 2013
    ..These aims will be addressed amorig the chimpanzees at Gombe National Park, the longest, continuous chimpanzee study site in the world...
  46. Vasopressin Receptor Polymorphism and Social Cognition
    William D Hopkins; Fiscal Year: 2013
    ..genetic and neurobiological basis of individual differences in socio-communicative behavior and cognition in the chimpanzee, a potential valuable species for modeling aspects of the autism phenotype...
  47. Chimpanzee Biomedical Research Resource
    Christian R Abee; Fiscal Year: 2011
    ..provided by applicant): This is a competing renewal application of a cooperative agreement supporting the "Chimpanzee Biomedical Research Resource" (CBRR) at the Michale E...
  48. Genomic Studies Mammalian Y Chromosomes
    David C Page; Fiscal Year: 2013
    ..These genomic studies recently culminated in the finished and annotated sequences of the human and chimpanzee Y chromosomes, which are, to date, the only sex-specific chromosomes to have been sequenced from any species, ..
  49. Christian R Abee; Fiscal Year: 2016
    ..provided by applicant): This is a competing renewal application of a cooperative agreement supporting the "Chimpanzee Biomedical Research Resource" (CBRR) at the Michale E...
  50. OPERATION AND MAINTENANCE OF A CHIMPANZEE FACILITY
    Brian Corning; Fiscal Year: 2012
    Contractor operates and maintains a chimpanzee facility called the Alamogordo Primate Facility (APF) located on the Holloman Air Force Base in Alamogordo, New Mexico...
  51. OPERATION AND MAINTENANCE OF A CHIMPANZEE FACILITY
    Brian Corning; Fiscal Year: 2011
    Contractor operates and maintains a chimpanzee facility called the Alamogordo Primate Facility (APF) located on the Holloman Air Force Base in Alamogordo, New Mexico...
  52. VETERINARY/ANIMAL CARE SERVICES
    D Rick Lee; Fiscal Year: 2009
    Contractor operates and maintains a chimpanzee facility called the Alamogordo Primate Facility (APF) located on the Holloman Air Force Base in Alamogordo, New Mexico...
  53. VETERINARY/ANIMAL CARE SERVICES
    D Rick Lee; Fiscal Year: 2010
    Contractor operates and maintains a chimpanzee facility called the Alamogordo Primate Facility (APF) located on the Holloman Air Force Base in Alamogordo, New Mexico...
  54. VETERINARY/ANIMAL CARE SERVICES
    D Rick Lee; Fiscal Year: 2011
    Contractor operates and maintains a chimpanzee facility called the Alamogordo Primate Facility (APF) located on the Holloman Air Force Base in Alamogordo, New Mexico...
  55. Daniel R Schrider; Fiscal Year: 2015
    ..function, the proposed project would allow for detection of losses-of-function occurring since the human- chimpanzee divergence...
  56. Cellular Learning and information Outside of the Brain
    Michael Levin; Fiscal Year: 2005
    ..such as memory in plants and protozoa, and the occasional hydrocephalic patient with <30% of the cortex of a chimpanzee but above-normal intelligence) suggest that we have much to learn about the substratum of memories and the ..
  57. Michael Emerman; Fiscal Year: 2015
    ..the evolution and function of APOBEC3DE which is a restriction factor that has rapidly evolved since the human-chimpanzee divergence, and we will the exploit the natural infection of African Green Monkeys (AGMs) subspecies with ..
  58. NATIONAL CHIMPANZEE BREEDING AND RESEARCH PROGRAM
    Michale Keeling; Fiscal Year: 1999
    ..We offer a professional staff with a combined 47 years of experience in chimpanzee care and management and a technical and animal care cadre with a combined 50 years of experience...
  59. Engineered 3-D Human Liver Tissue for Hepatitis Studies
    BRIAN NAUGHTON; Fiscal Year: 2004
    ..Unfortunately, to date the only non-human animal models are the chimpanzee and, with a variety of severe limitations, an immunodeficient xenotransplant mouse model...
  60. CHIMPANZEE BREEDING AND RESEARCH PROGRAM
    Jo Fritz; Fiscal Year: 1999
    ..S., the Primate Foundation of Arizona (PFA) proposes to continue to maintain a chimpanzee breeding colony that will produce further generations of breeding animals and to meet current and future ..
  61. Plant-derived vaccines against hepatitis C Cooperative *
    Charles Arntzen; Fiscal Year: 2009
    ..gpE1 and gpE2 are the leading vaccine candidates for antibody-mediated protection, showing protection in chimpanzee. However, gpE1/gpE2 is currently produced in cultured mammalian cells, with a limited capacity for scale-up to ..
  62. Genetic Vaccine to Rabies Virus
    Hildegund Ertl; Fiscal Year: 2006
    ..The vaccines to be evaluated are based on an E1-deleted simian adenoviral vector derived from a chimpanzee isolate...
  63. GENETIC MANAGEMENT OF CHIMPANZEE BREEDING AND RESEARCH
    John Ely; Fiscal Year: 1999
    The objective in establishing the Chimpanzee Breeding and Research Program (CBRP) breeding colonies was to insure a steady supply of healthy chimpazees for future biomedical research needs...
  64. HIV-1 Vaccine Based on Chimp Serotypes of Adenovirus
    Hildegund C J Ertl; Fiscal Year: 2012
    This program focuses on vaccine candidates for HIV-1 based on two replication-defective chimpanzee (chimp) adenovirus (Ad) vectors, termed AdC6 and AdC7. The program has four interlinked goals...

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