Genomes and Genes
Alias: rhesus macaque, rhesus macaques, rhesus monkeys, Macaca mulatta
Publications281 found, 100 shown here
- Evolutionary and biomedical insights from the rhesus macaque genomeRichard A Gibbs
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
Science 316:222-34. 2007..Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research...
- Compensatory changes in the cytoplasmic tail of gp41 confer resistance to tetherin/BST-2 in a pathogenic nef-deleted SIVRuth Serra-Moreno
Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
Cell Host Microbe 9:46-57. 2011..domain of SIV gp41, acquired by a nef-deleted virus that regained a pathogenic phenotype in infected rhesus macaques, restore resistance to tetherin...
- Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primatesMelissa Suter
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
FASEB J 25:714-26. 2011..In summary, the data suggest that peripheral Npas2 expression is uniquely vulnerable to diet exposure...
- Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary diseaseChristine L Wohlford-Lenane
Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
J Virol 83:11385-90. 2009..RTD-1-treated, SARS-CoV-infected mice displayed altered lung tissue cytokine responses 2 and 4 days postinfection compared to those of untreated animals, suggesting that one possible mechanism of action for RTD-1 is immunomodulatory...
- p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alphaChristopher O'Connor
Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA
J Virol 84:5997-6006. 2010..to the cross-species transmission of retroviruses, the most well known being the TRIM5alpha protein from rhesus macaques, which potently inhibits human immunodeficiency virus type 1 (HIV-1) infection...
- Species specificity of human interleukin-3 demonstrated by cloning and expression of the homologous rhesus monkey (Macaca mulatta) geneH Burger
Institute of Applied Radiobiology and Immunology TNO, Rijswijk, The Netherlands
Blood 76:2229-34. 1990..preclinical studies on homologous interleukin-3 (IL-3) in primate species, we isolated the gene encoding Rhesus monkey IL-3 (RhIL-3). The nucleotide sequence of the RhIL-3 gene displayed 92...
- Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2Bin Jia
Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA, USA
PLoS Pathog 5:e1000429. 2009..These results identify Nef as the viral gene product of SIV that opposes restriction by tetherin in rhesus macaques and sooty mangabeys, and reveal species-specificity in the activities of both Nef and Vpu in overcoming ..
- Decrease in hypothalamic Kiss1 and Kiss1r expression: a potential mechanism for fasting-induced suppression of the HPG axis in the adult male rhesus monkey (Macaca mulatta)F Wahab
Laboratory of Reproductive Neuroendocrinology, Department of Animal Sciences, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan
Horm Metab Res 43:81-5. 2011..In addition, our finding of lower expression of KISS1R in fasted monkeys provides an explanation for the attenuation in the HPG axis response to peripheral kisspeptin challenge during short-term fasting...
- Trafficking of some old world primate TRIM5α proteins through the nucleusFelipe Diaz-Griffero
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Retrovirology 8:38. 2011..Interestingly, other proteins from the TRIM family localize to the nucleus. Therefore, we tested the possibility that TRIM5 proteins traffic to the nucleus and the impact of this trafficking on retroviral restriction...
- The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein VpxEfrem S Lim
Department of Microbiology, University of Washington, Seattle, WA 98195, USA
Cell Host Microbe 11:194-204. 2012..We conclude that vpr neofunctionalized to degrade SAMHD1 even prior to the birth of a separate vpx gene, thereby initiating an evolutionary arms race with SAMHD1...
- Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyesT Nakajima
Senju Laboratory of Ocular Sciences, Senju Pharmaceutical Co, Ltd, Kobe, Hyogo 650 0047 Japan
Exp Eye Res 85:651-8. 2007..cDNA for lacritin from rhesus macaque contained 547 bp, with 411 bp in an open reading frame (ORF) encoding a protein of 137 amino acids...
- Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5αAlberto Brandariz-Nuñez
Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, NY 10461, USA
Virology 435:463-71. 2013..Overall, our results do not support a role for SIMs or SUMOylation in the antiviral properties of TRIM5α...
- Expression of the neuregulin receptor ErbB4 in the brain of the rhesus monkey (Macaca mulatta)Jörg Neddens
Section on Molecular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 6:e27337. 2011..This interpretation is functionally consistent with the genetic association of NRG1 and ERBB4 with schizophrenia...
- Convergent evolution of escape from hepaciviral antagonism in primatesMaulik R Patel
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
PLoS Biol 10:e1001282. 2012..Our analyses also provide a means by which primates might clear infections by extant hepaciviruses like HCV...
- Molecular cloning of monkey CYP2C43 cDNA and expression in yeastTamihide Matsunaga
Division of Pharmacy, Shinshu University Hospital, Matsumoto, Japan
Drug Metab Pharmacokinet 17:117-24. 2002A cDNA clone designated as CYP2C43 was isolated from the rhesus monkey liver cDNA library...
- A snapshot of the Mamu-B genes and their allelic repertoire in rhesus macaques of Chinese originNel Otting
Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands
Immunogenetics 60:507-14. 2008The major histocompatibility complex class I gene repertoire was investigated in a large panel of rhesus macaques of Chinese origin...
- Insulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase CHeidi K Ortmeyer
Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Antioxid Redox Signal 14:207-19. 2011..are considered key integrators of metabolism, we sought to determine in biopsies from lean and obese aging rhesus monkeys the nature of defects in insulin activation and, further, the potential for mitigation of such defects by an ..
- Rhesus monkey TRIM5alpha restricts HIV-1 production through rapid degradation of viral Gag polyproteinsRyuta Sakuma
Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Nat Med 13:631-5. 2007..Tripartite motif-containing 5 isoform-alpha (TRIM5alpha) protein from rhesus monkey (TRIM5alpharh) restricts human immunodeficiency virus type 1 (HIV-1) infection at a postentry, preintegration ..
- Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteinsXing Li
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 286:27959-70. 2011..These results support a model in which both ends of the core TRIM dimer (RING-B-box 2 at one end and Linker 2 at the other) contribute to the formation of higher order arrays...
- Trim5alpha protein restricts both HIV-1 and murine leukemia virusMelvyn W Yap
Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Proc Natl Acad Sci U S A 101:10786-91. 2004..Recently, Trim5alpha protein from rhesus monkey was found to restrict HIV-1...
- Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolutionAnders L Kjeldbjerg
Department of Molecular Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
BMC Evol Biol 8:266. 2008..However, a few intact and very old HERV genes exist, and likely are beneficial for the host. We here address evolutionary aspects of two HERV-V envelope genes, ENVV1 and ENVV2, located in tandem and containing a long open reading frame...
- TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitroLESA R BLACK
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, A 5301 Medical Center North, Nashville, TN 37232 2363, USA
J Virol 84:6564-9. 2010..A previous study reported that rhesus macaque TRIM5alpha protein stably associates with cylindrical complexes formed by assembly of recombinant HIV-1 CA-NC ..
- TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new speciesAndrea Kirmaier
New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts, United States of America
PLoS Biol 8:. 2010..source of multiple, successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in rhesus macaques, and SIVstm in stump-tailed macaques...
- A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensinsY Q Tang
Department of Pathology, College of Medicine, University of California, Irvine, CA 92697, USA
Science 286:498-502. 1999Analysis of rhesus macaque leukocytes disclosed the presence of an 18-residue macrocyclic, tridisulfide antibiotic peptide in granules of neutrophils and monocytes...
- Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytesY Q Tang
Department of Pathology, University of California, Irvine, California 92697, USA
Infect Immun 67:6139-44. 1999Experiments to isolate and characterize rhesus macaque myeloid alpha-defensins (RMADs) were conducted...
- Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simiansSandra Blaise
Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, UMR 8122 CNRS, Institut Gustave Roussy, 94805 Villejuif, France
J Virol 78:1050-4. 2004..The functional characterization of the identified envelopes is strongly indicative of an ancestral retrovirus infection and endogenization, with some of the envelope functions subsequently retained in evolution...
- Genetic makeup of the DR region in rhesus macaques: gene content, transcripts, and pseudogenesNanine de Groot
Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, The Netherlands
J Immunol 172:6152-7. 2004In the human population, five major HLA-DRB haplotypes have been identified, whereas the situation in rhesus macaques (Macaca mulatta) is radically different...
- Patterns of evolution of host proteins involved in retroviral pathogenesisMillan Ortiz
Institute of Microbiology, University of Lausanne, Switzerland
Retrovirology 3:11. 2006....
- Visualization of a proteasome-independent intermediate during restriction of HIV-1 by rhesus TRIM5alphaEdward M Campbell
Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA
J Cell Biol 180:549-61. 2008..However, the underlying restriction mechanism remains unclear. In this study, we show that during rhesus macaque TRIM5alpha (rhTRIM5alpha)-mediated restriction of HIV-1 infection, cytoplasmic HIV-1 viral complexes can ..
- Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infectionMatthew D Eberly
Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Immunol 182:1439-48. 2009..Our results demonstrate that IL-15 contributes to the increased susceptibility of memory CD4 T cells to SIV during the early phase of acute SIV infection...
- Characterization of rhesus macaque KIR genotypes and haplotypesPhilip H Kruse
Primate Genetics Laboratory, German Primate Center Leibniz Institute for Primate Research, Gottingen, Germany
Immunogenetics 62:281-93. 2010..b>Rhesus macaques are often used as important animal models of human diseases such as, e.g. AIDS...
- A single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5 alphaAyumu Kuroishi
Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
Retrovirology 7:58. 2010..This virus (NL-4/5S6/7SvifS) was supposed to escape from host restriction factors cyclophilin A, CM TRIM5 alpha, and APOBEC3G. However, the replicative capability of NL-4/5S6/7SvifS in human cells was severely impaired...
- Adaptation of HIV-1 to cells expressing rhesus monkey TRIM5αBeatriz Pacheco
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Virology 408:204-12. 2010..We adapted an HIV-1 isolate to replicate in cells expressing TRIM5α(rh) from rhesus monkeys, an Old World species...
- The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeysWendy W Yeh
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Virol 85:10389-98. 2011..TRIM5 may also contribute to susceptibility to mucosal acquisition of simian immunodeficiency virus (SIV) in rhesus monkeys. We explored this hypothesis by establishing 3 cohorts of Indian-origin rhesus monkeys with different TRIM5 ..
- Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency virusesAlex A Compton
Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America
PLoS Pathog 9:e1003135. 2013..Our analysis of virus-driven evolution describes an ancient yet ongoing genetic conflict between simian primates and lentiviruses on a million-year time scale...
- Bioinformatic approaches to identifying orthologs and assessing evolutionary relationshipsEric J Vallender
Division of Neurosciences, New England Primate Research Center, Harvard Medical School, Pine Hill Drive, Southborough Campus, Southborough, MA 01772, USA
Methods 49:50-5. 2009..Through these steps any researcher seeking to make use of non-human primate genetic information will have the tools at their disposal to ascertain where errors exist and to remedy them once encountered...
- The MHC class I genes of the rhesus monkey. Different evolutionary histories of MHC class I and II genes in primatesJ E Boyson
University of Wisconsin, Madison, WI 53715, USA
J Immunol 156:4656-65. 1996..of the A and B loci we have cloned, sequenced, and in vitro translated 16 MHC class I cDNAs from two unrelated rhesus monkeys (Macaca mulatta) using both cDNA library screening and PCR amplification...
- Effects of fenofibrate on lipid parameters in obese rhesus monkeysD A Winegar
GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC 27709, USA
J Lipid Res 42:1543-51. 2001..The spontaneously obese rhesus monkey is a well-recognized animal model for the study of human obesity and type 2 diabetes, and many of these ..
- Cloning of rhesus monkey killer-cell Ig-like receptors (KIRs) from early pregnancy deciduaR L Grendell
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715 1299, USA
Tissue Antigens 58:329-34. 2001To define the killer-cell Ig-like receptors (KIR) molecules expressed within the decidua in the rhesus monkey, an early pregnancy rhesus decidual library was screened with an oligonucleotide located within the KIR D2 domain...
- Characterization of TRIM5alpha trimerization and its contribution to human immunodeficiency virus capsid bindingHassan Javanbakht
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
Virology 353:234-46. 2006..Therefore, TRIM5alpha trimerization makes a major contribution to its avidity for the retroviral capsid, and to the ability to restrict virus infection...
- Evidence that down regulation of hypothalamic KiSS-1 expression is involved in the negative feedback action of testosterone to regulate luteinising hormone secretion in the adult male rhesus monkey (Macaca mulatta)M Shibata
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Neuroendocrinol 19:432-8. 2007..To this end, 12 castrated adult male rhesus monkeys were implanted with either testosterone containing or empty Silastic capsules...
- Functional interplay between the B-box 2 and the B30.2(SPRY) domains of TRIM5alphaXing Li
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
Virology 366:234-44. 2007..2(SPRY) domain. Thus, some alterations in the TRIM5alpha B-box 2 domain apparently affect the orientation or conformation of the B30.2(SPRY) domain, influencing capsid recognition...
- Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infectionsJudith N Mandl
Graduate Program in Population Biology, Ecology and Evolution, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, USA
Nat Med 14:1077-87. 2008Pathogenic HIV infections of humans and simian immunodeficiency virus (SIV) infections of rhesus macaques are characterized by generalized immune activation and progressive CD4(+) T cell depletion...
- Protein kinase R reveals an evolutionary model for defeating viral mimicryNels C Elde
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Nature 457:485-9. 2009....
- Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loadsPavel Bostik
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
J Immunol 182:3638-49. 2009..In the SIV-infected rhesus macaque (RM) model of AIDS, several families of killer inhibitory Ig-related receptors (KIR receptors) corresponding ..
- Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortexJ R Glausier
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA
Neuroscience 167:428-38. 2010..microscopy to quantitatively determine the localization of DARPP-32 and I-1 in the neuropil of the rhesus monkey PFC...
- Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaquesPorntip Chaichompoo
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Cell Immunol 263:176-87. 2010..shown an association of KIR3DL alleles 13 and 14 with high plasma viral loads in a cohort of SIV-infected rhesus macaques. To gain a more detailed understanding of the role of KIR polymorphisms, our laboratory herein conducted ..
- Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeysSo yon Lim
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 6:e1000997. 2010..between CCL3L CNV and clinical sequelae of the simian immunodeficiency virus (SIV) infection in vivo in rhesus monkeys. The present study was initiated to explore the possibility of an association of CCL3L CNV with the control of ..
- Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primatesJennifer G Sambrook
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kindgom
Genome Res 15:25-35. 2005..genes (mmKIRnewI, mmKIR1D, mmKIR2DL4, mmKIR3DL10, mmKIR3DL1) are present in the haplotype sequenced for the rhesus macaque (Macaca mulatta)...
- Characterization of the rhesus macaque (Macaca mulatta) equivalent of HLA-FN Otting
Department of Chronic and Infectious Diseases, ITRI TNO, Rijswijk, The Netherlands
Immunogenetics 38:141-5. 1993Nucleotide sequence analysis of rhesus macaque major histocompatibility complex class I cDNAs allowed the identification of the orthologue of HLA-F, designated Mamu-F...
- Definition of human immunodeficiency virus type 1 gp120 and gp41 cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I alleles in simian-human immunodeficiency virus-infected rhesus monkeysG Voss
Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215, USA
J Virol 70:7335-40. 1996..To facilitate performing such CTL studies, we have defined two HIV-1 Env CTL epitopes in SHIV-infected rhesus monkeys and characterized the major histocompatibility complex (MHC) class I alleles that bind these Env peptide ..
- Mamu-I: a novel primate MHC class I B-related locus with unusually low variabilityJ A Urvater
Wisconsin Regional Primate Research Center, Department of Genetics, University of Wisconsin, Madison, WI 53715, USA
J Immunol 164:1386-98. 2000The rhesus macaque is an important animal model for several human diseases and organ transplantation. Therefore, definition of the MHC of this species is crucial to the development of these models...
- Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human moleculesR Bals
Medizinische Klinik und Poliklinik I, Hospital of the University of Munich, Campus Grosshadern, Schwerpunkt Pneumologie, Ludwig Maximilians Universitat, Marchioninstr 15, 81377 Munich, Germany
Clin Diagn Lab Immunol 8:370-5. 2001..The present study demonstrates that beta-defensins and cathelicidins of rhesus monkeys are close homologues to the human molecules and indicate that nonhuman primates represent valid model ..
- Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infectionRegina Hofmann-Lehmann
Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
AIDS Res Hum Retroviruses 18:627-39. 2002..cytokine and beta-chemokine profiles during pathogenesis of lentiviral infection and progression to AIDS in rhesus macaques, we established new quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assays ..
- Pervasive adaptive evolution in primate seminal proteinsNathaniel L Clark
Department of Genome Sciences, University of Washington, Seattle, Washington, USA
PLoS Genet 1:e35. 2005....
- Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammalsSara L Sawyer
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS Pathog 3:e197. 2007..Astonishingly, this same loop is under positive selection in the multiple cow TRIM5 genes as well, indicating that this small structural loop may be a viral recognition motif spanning a hundred million years of mammalian evolution...
- Identification of oocyte-selective NLRP genes in rhesus macaque monkeys (Macaca mulatta)Patrick McDaniel
Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
Mol Reprod Dev 76:151-9. 2009..We identified 14 NLRP gene homologues and examined their spatial and temporal expression in rhesus macaque monkeys (Macaca mulatta)...
- Interleukin-18 predicts atherosclerosis progression in SIV-infected and uninfected rhesus monkeys (Macaca mulatta) on a high-fat/high-cholesterol dietJennifer H Yearley
Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
Lab Invest 89:657-67. 2009..Acutely simian immunodeficiency virus-infected and uninfected rhesus monkeys (Macaca mulatta) on an atherogenic diet were evaluated prospectively for atherosclerotic lesion development relative to a ..
- Evidence for balancing selection acting on KIR2DL4 genotypes in rhesus macaques of Indian originJeroen H Blokhuis
Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Lange Kleiweg 139, Rijswijk, 2288 GJ, The Netherlands
Immunogenetics 61:503-12. 2009..In both humans and rhesus macaques, particular types of non-classical MHC class I molecules are predominantly expressed on the trophoblast...
- Simian TRIM5alpha proteins reduce replication of herpes simplex virusNatalia Reszka
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
Virology 398:243-50. 2010..that several simian TRIM5alpha proteins can restrict HSV replication, with the TRIM5alpha protein of rhesus macaques showing the strongest inhibition of HSV infection...
- Prion protein gene variation among primatesH M Schätzl
Department of Neurology, University of California, San Francisco 94143, USA
J Mol Biol 245:362-74. 1995..Alignment of primate and other mammalian PrP sequences suggests that codons between 90 and 130 have a profound influence on the transmissibility of prions from one species to another...
- Identification of a novel MHC class I gene, Mamu-AG, expressed in the placenta of a primate with an inactivated G locusJ E Boyson
Department of Pathology and Laboratory Medicine, Wisconsin Regional Primate Research Center, University of Wisconsin Madison, 53715, USA
J Immunol 159:3311-21. 1997..of a novel nonclassical MHC class I locus expressed in the placenta of the rhesus monkey, Mamu-AG (Macaca mulatta-AG). Although unrelated to HLA-G, Mamu-AG encodes glycoproteins with all of the characteristics of HLA-G...
- Diversity of the killer cell Ig-like receptors of rhesus monkeysK L Hershberger
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Immunol 166:4380-90. 2001..Therefore, cDNAs encoding the KIR molecules of five rhesus monkeys were characterized, and were found to differ from the KIR molecules identified in humans and chimpanzees...
- Circular minidefensins and posttranslational generation of molecular diversityL Leonova
Department of Medicine, UCLA School of Medicine, UCLA, Los Angeles, California 90095 1690, USA
J Leukoc Biol 70:461-4. 2001We purified two new minidefensins (RTD-2 and RTD-3) from the bone marrow of rhesus monkeys. Both were circular octadecapeptides that contained three intramolecular disulfide bonds and were homologous to RTD-1, a circular (theta) defensin ..
- Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and humanQ Liu
Departments of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Endocrinology 142:4529-39. 2001..Thirty-six novel cDNAs were isolated and sequenced from a subtracted Macaca mulatta epididymis library...
- Cystatin 11: a new member of the cystatin type 2 familyKatherine G Hamil
Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill 27599, USA
Endocrinology 143:2787-96. 2002Cystatin (CST)11, a novel member of the CST type 2 family of cysteine protease inhibitors, was identified in Macaca mulatta epididymis by subtractive hybridization cloning. The human CST11 gene on chromosome 20p11...
- Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 18.104.22.168)Steven L Coon
Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4480, USA
J Clin Endocrinol Metab 87:4699-706. 2002..In this report AANAT was studied in the rhesus macaque to better understand human melatonin regulation...
- Evolutionary stability of MHC class II haplotypes in diverse rhesus macaque populationsGaby G M Doxiadis
Department of Comparative Genetics and Refinement and Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
Immunogenetics 55:540-51. 2003A thoroughly characterized breeding colony of 172 pedigreed rhesus macaques was used to analyze exon 2 of the polymorphic Mamu- DPB1, -DQA1, -DQB1, and - DRB loci...
- Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansionNatalay Kouprina
Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland, USA
PLoS Biol 2:E126. 2004..the complete ASPM gene, including promoter regions and introns, from chimpanzee, gorilla, orangutan, and rhesus macaque by transformation-associated recombination cloning in yeast...
- Evolution of the tumor suppressor BRCA1 locus in primates: implications for cancer predispositionAdam Pavlicek
Genetic Information Research Institute, Mountain View, CA, USA
Hum Mol Genet 13:2737-51. 2004..Finally, on the basis of protein sequence conservation, we identified missense changes that are likely to compromise BRCA1 function...
- Unparalleled complexity of the MHC class I region in rhesus macaquesNel Otting
Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, PO Box 3306, 2280 GH Rijswijk, The Netherlands
Proc Natl Acad Sci U S A 102:1626-31. 2005..b>Rhesus macaques express multiple dominant Mamu-A and Mamu-B transcripts (majors) per chromosome, which are characterized by ..
- Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR-alpha agonist (K-111) administration in rhesus monkeysHeidi K Ortmeyer
Obesity and Diabetes Research Center, Deparment of Physiology, University of Maryland School of Medicine, 10 N Greene St, Rm 4B 201, Baltimore, MD 21201, USA
Am J Physiol Regul Integr Comp Physiol 288:R1509-17. 2005....
- Adaptive evolution of primate TRIM5alpha, a gene restricting HIV-1 infectionHong Liang Liu
Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan, China
Gene 362:109-16. 2005....
- Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3HMolly OhAinle
Molecular and Cellular Biology Program, University of Washington, Seattle 98109, USA
J Virol 80:3853-62. 2006..The consequences of the lack of antiviral activity of human APOBEC3H are likely to be relevant to the current-day abilities of humans to combat retroviral challenges...
- Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3GBärbel Schröfelbauer
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
J Virol 80:5984-91. 2006..HIV type 1 (HIV-1) Vif counteracts hA3G but not rhesus macaque APOBEC3G (rhA3G) or African green monkey (AGM) APOBEC3G (agmA3G) because of a failure to bind the nonhuman ..
- Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaquesAndrea Weiler
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53715, USA
Immunogenetics 58:1003-9. 2006..We have identified several SIV-infected Indian rhesus macaques that naturally control viral replication...
- Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alphaRuchi M Newman
Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, MA 01772, USA
Proc Natl Acad Sci U S A 103:19134-9. 2006....
- An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta)Bret M Windsor-Engnell
Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, WI 53715 1299, USA
Am J Physiol Endocrinol Metab 292:E1000-9. 2007..Six prepubertal female rhesus monkeys (17.4 +/- 0.1 mo of age) received lesions in the PH, three prepubertal females (17.5 +/- 0...
- Widespread expression of ErbB2, ErbB3 and ErbB4 in non-human primate brainMia Thompson
MiNDS Unit Clinical Brain Disorders Branch, IRP NIMH NIH, NIH, Mail Stop 1385, Building 10 Room 4D18, Bethesda, MD 20892, USA
Brain Res 1139:95-109. 2007..The ubiquitous expression of ErbB receptors indicates that many cell populations throughout the brain of juvenile and adult primates have the potential to respond to NRG-1 in a variety of ways...
- MHC class I A region diversity and polymorphism in macaque speciesNel Otting
Department of Comparative Genetics and Refinement, Biomedical Primate Research Centre, P O Box 3306, 2280 GH, Rijswijk, The Netherlands
Immunogenetics 59:367-75. 2007..To shed light on this issue, rhesus macaques from a Chinese population and a panel of cynomolgus monkeys (Macaca fascicularis) were screened for various A ..
- Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta)J B Hoffman
Division of Psychobiology, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
Endocrine 31:202-11. 2007..016) in terms of plasma cortisol than were l/l females. These data indicate that adult female rhesus monkeys with the s-variant polymorphism in the SERT gene exhibit metabolic and reproductive alterations in conjunction ..
- Full-length cDNA cloning and protein three-dimensional structure modeling of factor VII of rhesus monkey, Macaca mulattaJiandong Wang
Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu 610041, PR China
Blood Cells Mol Dis 40:237-43. 2008..In this paper, we report the full-length cDNA sequences of rhesus monkey FVII...
- Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteinsCesar A Virgen
Aaron Diamond AIDS Research Center, 455 1st Avenue, New York, NY 10016, USA
J Virol 81:13932-7. 2007The inability of human immunodeficiency virus type 1(HIV-1) to replicate in rhesus macaque cells is in part due to the failure of HIV-1 Vif to counteract the restriction factor APOBEC3G...
- Identification of MHC class I sequences in Chinese-origin rhesus macaquesJulie A Karl
Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
Immunogenetics 60:37-46. 2008..exhibiting distinctive morphological and physiological characteristics, Indian- and Chinese-origin rhesus macaques, are commonly used in research...
- Independent evolution of an antiviral TRIMCyp in rhesus macaquesSam J Wilson
Medical Research Council Centre for Medical Molecular Virology, Department of Infection, Royal Free and University College Medical School, University College London, London W1T 4JF, United Kingdom
Proc Natl Acad Sci U S A 105:3557-62. 2008..Here, we show that the Old World monkey, rhesus macaque (Macaca mulatta), also encodes a TRIMCyp protein that has arisen independently from that in owl monkeys...
- Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaquesNicholas J Maness
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
J Virol 82:5245-54. 2008..However, possession of favorable alleles does not guarantee improved prognosis or viral control. In rhesus macaques, the MHC-I allele Mamu-B*17 is correlated with reduced viremia and is overrepresented in macaques that ..
- Rhesus monkeys and humans share common susceptibility genes for age-related macular diseasePeter J Francis
Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
Hum Mol Genet 17:2673-80. 2008..We genotyped a cohort of 137 unrelated rhesus macaques with and without macular drusen...
- Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activationDajana Paulmann
Department of Virology, University of Bremen, Leobener Strasse UFT, D 28359 Bremen, Germany
J Gen Virol 89:1593-604. 2008..This ability might be of vital importance for HAV, which is an exceptionally slow growing virus sensitive to IFN-beta, as it allows the virus to establish infection and maintain virus replication for a longer period of time...
- A splice site mutation converts an inhibitory killer cell Ig-like receptor into an activating oneJeroen H Blokhuis
Biomedical Primate Research Centre, Department of Comparative Genetics and Refinement, Lange Kleiweg 139, 2288 GJ Rijswijk, The Netherlands
Mol Immunol 46:640-8. 2009The killer cell Ig-like receptor (KIR) 3DH protein in rhesus macaques (Macaca mulatta) is thought to be an activating one because it contains a charged arginine in its transmembrane domain and has a truncated cytoplasmic domain...
- Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responsesAkiya Watakabe
Division of Brain Biology, National Institute for Basic Biology, 38 Nishigonaka Myodaiji, Okazaki 444 8585, Japan
Cereb Cortex 19:1915-28. 2009..The 5-HT2A agonist showed opposite effects. These results suggest that this serotonergic system controls the visual response in V1 for optimization of information processing toward the incoming visual inputs...
- Mucosal immunization in macaques upregulates the innate APOBEC 3G anti-viral factor in CD4(+) memory T cellsYufei Wang
Kings College London at Guy s Hospital, London SE1 9RT, England, UK
Vaccine 27:870-81. 2009..In vivo studies of APOBEC3G (A3G) were carried out in rhesus macaques, following mucosal immunization with SIV antigens and CCR5 peptides, linked to the 70kDa heat shock protein...
- Identification of 17 novel major histocompatibility complex-A alleles in a population of Chinese-origin rhesus macaquesX Ma
Center for Vaccines and Biotherapeutics, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
Tissue Antigens 73:184-7. 2009b>Rhesus macaques (Macaca mulatta) serve as important animal models for human disease and vaccine research...
- Serotonin transporter genotype modulates social reward and punishment in rhesus macaquesKarli K Watson
Department of Neurobiology, Duke University, LSRC Room, Durham, North Carolina, USA
PLoS ONE 4:e4156. 2009..Here we show that length polymorphisms in 5-HTTLPR predict social reward and punishment in rhesus macaques, a species in which 5-HTTLPR variation is analogous to that of humans.
- Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variantsMatthew W McNatt
Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America
PLoS Pathog 5:e1000300. 2009..Tetherin variants found in rhesus macaques (rh), African green monkeys (agm) and mice were able to inhibit HIV-1 particle release, but were resistant to ..
- Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarityJohn T Loffredo
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53706, USA
J Immunol 182:7763-75. 2009..In a similar fashion, 50% of Mamu-B*08-positive Indian rhesus macaques control SIVmac239 replication and become elite controllers with chronic-phase viremia <1000 viral RNA ..
- Nef proteins from simian immunodeficiency viruses are tetherin antagonistsFengwen Zhang
Aaron Diamond AIDS Research Center, Laboratory of Retrovirology, The Rockefeller University, New York, NY 10016, USA
Cell Host Microbe 6:54-67. 2009....
- A B-box 2 surface patch important for TRIM5alpha self-association, capsid binding avidity, and retrovirus restrictionFelipe Diaz-Griffero
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Virol 83:10737-51. 2009..2(SPRY) domains. The TRIM5alpha(rh) protein from rhesus monkeys recognizes the human immunodeficiency virus type 1 (HIV-1) capsid as it enters the host cell and blocks virus ..
- Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary hormonesS Ramaswamy
Departments of Cell Biology and Physiology, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Neuroendocrinol 21:795-804. 2009..also influences the function of the primate pituitary directly, two experiments were performed in adult male rhesus monkeys. First, the distribution of kisspeptin-containing cells in the pituitary was described using fluorescence ..
- Alteration of serotonin transporter messenger RNA level in the peripheral blood mononuclear cells from simian/human immunodeficiency virus infected Chinese rhesus macaques (Macaca mulatta)Kai Yu
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS STD Control and Prevention, China CDC, Beijing 100050, PR China
Brain Behav Immun 24:298-305. 2010..levels of SERT mRNA in the peripheral blood mononuclear cells (PBMCs) and various tissues from normal Chinese rhesus macaques, in PBMCs from 32 SHIV-sf162p4 infected rhesus macaques and from 8 rhesus macaques before and 7, 14, 21, 28 ..
- Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestrationRavindra K Gupta
Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, United Kingdom
Proc Natl Acad Sci U S A 106:20889-94. 2009..SIVtan) encodes an envelope glycoprotein (SIVtan Env) able to counteract tetherin from Tantalus monkeys, rhesus monkeys, sooty mangabeys, and humans, but not from pigs...
- Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaquesYasuhiro Uno
Genome Research Group, Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd, 16 1 Minami Akasaka, Kainan, Wakayama 642 0017, Japan
Drug Metab Dispos 38:209-14. 2010Cynomolgus and rhesus macaques are frequently used in preclinical trials due to their close evolutionary relationships to humans...
- SPECIFIC PATHOGEN FREE RHESUS MACAQUE BREEDING PROGRAMGreg Westergaard; Fiscal Year: 2004..Health (NIH) also recognizes that there is a special need for major histocompatibility complex (MHC) defined rhesus macaques for certain types of AIDS-related research...
- Pathogenesis of Lyme Borreliosis in the Rhesus MonkeyMARIO PHILIPP; Fiscal Year: 2007..burgdorferi. We will use tissues and cells from the brain of rhesus macaques, a model developed under this Cooperative Agreement. Specific Aims; SA-I: Experiments ex vivo...
- Clayton A Wiley; Fiscal Year: 2016..to use a well-established non-human primate (NHP) model of chronic lentiviral infection, SIV infection of Macaca mulatta (Rhesus Macaque RM), to model HAND in aged macaques (>20 years old), map the neurological signs to ..
- Complete genomic DNA sequence of the sooty mangabey MHCDaniel E Geraghty; Fiscal Year: 2012..for functional testing of genetic factors that relate to long- term nonprogression of SIV infection in rhesus macaques, and then to the same phenotype for HIV-1 infection in humans...
- DEVELOPMENT OF A PRIMATE GENOMIC RESOURCEMichael G Katze; Fiscal Year: 2012..upon resources constructed during the original funding period in which we developed extensive rhesus macaque (Macaca mulatta)-specific genomic tools...
- Epstein-Barr Virus: A persistent vaccine vectorFREDERICK C WANG; Fiscal Year: 2010..The LCV naturally infecting rhesus macaques (rhLCV) has been fully sequenced and has an identical repertoire of viral genes as EBV...
- SIMIAN VACCINE EVALUATION UNITSMark Lewis; Fiscal Year: 2011..Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-..
- SIMIAN VACCINE EVALUATION UNIT (SVEU)Phillip D Markham; Fiscal Year: 2011..Units (SVEUs) are as follows: 1 Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-..
- SIMIAN VACCINE EVALUATION UNIT (SVEU)Dave Anderson; Fiscal Year: 2011..Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-..
- SIMIAN VACCINE EVALUATION UNITSMark Lewis; Fiscal Year: 2010..Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-..
- SIMIAN VACCINE EVALUATION UNIT (SVEU)Phillip D Markham; Fiscal Year: 2010..Units (SVEUs) are as follows: 1 Acquisition and testing of non-human primates (Primary emphasis will be on rhesus macaques (Macaca mulatta) of Indian origin, Chinese-origin macaques, or other nonhuman primate species, such as pig-..
- Genomic characterization of a nonhuman primate model for AIDS researchMARY KATHARINE RUDD; Fiscal Year: 2011..In both humans and rhesus macaques it has been demonstrated that host genetic variation can provide resistance or susceptibility to the ..
- Michelle H Larsen; Fiscal Year: 2014..We will test hypothesis in the rhesus macaque model of infant oral SIV infection...
- Development of a novel vaccine for protection against gammaherpesvirus infectionBlossom A Damania; Fiscal Year: 2010..RRV was originally isolated from rhesus macaques, is very closely related to KSHV and most of the eighty open reading frames (ORFs) of RRV share high homology ..
- Methamphetamine and Immune Cells in NeuroAIDSMaria Cecilia Garibaldi Marcondes; Fiscal Year: 2012..We have found that Meth modulates the phenotype of brain and peripheral innate immune cells in the SIV/Rhesus macaque model, increasing cytokine secretion and enriching virus targets CCR5+ cells7, and in vitro...
- Viral evolution in peropheral macrophages and brain during progression to AIDSMarco Salemi; Fiscal Year: 2013..The Rhesus macaque model of neuroAIDS will be employed to study the evolution of the viral quasispecies during disease ..
- Joseph M McCune; Fiscal Year: 2014..tolerance in the human fetus, we will rely upon a well-characterized experimental model (SIV infection of the rhesus macaque) to induce tolerance by one of two proven routes (injection of antigen in utero and oral administration of ..
- SIV-specific Mamu-E-restricted CD8+ T cellsDavid I Watkins; Fiscal Year: 2012..We have conducted preliminary studies in SIV-infected Indian rhesus macaques and have shown that SIV- derived peptides conforming to the HLA-E binding motif are recognized in IFN3 ..
- Jay Rappaport; Fiscal Year: 2014..of a monocyte subset (CD14+/CD163+/CD16+) in peripheral blood in patients with HIV infection and SIV infected rhesus macaques. These monocytes in circulation appear to represent precursors of the perivascular macrophages accumulating ..
- ESTABLISHMENT OF A SPF RHESUS MACAQUE COLONYLARRY BILL CUMMINS; Fiscal Year: 2011..free (SPF) Macaca mulatta for AIDS-related research by maintaining a production colony of Indian-origin rhesus monkeys that are SPF for herpes B virus, SIV, SRV, and STLV-1, and to fulfill specific research needs in the immediate ..
- Robert E Lanford; Fiscal Year: 2016..The specific aims are as follows: 1. To make 60-70 pedigreed SPF rhesus macaques available for research annually;2...
- Intestinal cytokine and T cell homeostasis in SIV infectionSatya Dandekar; Fiscal Year: 2013..We propose to utilize a novel in vivo intestinal loop model in SIV infected rhesus macaques to capture early events of host-microbe interactions at the mucosal site and characterize the responses of ..
- ESTABLISHMENT OF SPF RHESUS MACAQUE BREEDING COLONY: HIV GENOMEKeith G Mansfield; Fiscal Year: 2011..The limited availability of Indian-origin rhesus macaques (Macaca mulatta) specific pathogen free of B virus (BV), Simian T lymphotropic Virus (STLV-1), Simian ..
- Roger D Spealman; Fiscal Year: 2014..b>Rhesus macaques free of infection with Macacine herpesvirus 1 (B virus)...
- Kevin M Weeks; Fiscal Year: 2016..two additional HIV-1 related viruses, the simian immunodeficiency virus from chimpanzees (SIVcpz) and from the rhesus macaque (SIVmac)...
- MHC-BOUND, SIV-DERIVED, CTL AND HTL EPITOPESDavid I Watkins; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE (provided by applicant): SIV infection in Indian rhesus macaques is the best animal model for studying HIV-infected humans...
- MHC-BOUND, SIV-DERIVED, CTL AND HTL EPITOPESDavid I Watkins; Fiscal Year: 2011..PUBLIC HEALTH RELEVANCE (provided by applicant): SIV infection in Indian rhesus macaques is the best animal model for studying HIV-infected humans...
- The Early Events Determining SIV Rectal TransmissionQingsheng Li; Fiscal Year: 2013..Studying HIV-1 vaginal transmission in the highly relevant SIV-rhesus macaque model has revealed important events critical for transmission, such as target cell availability, innate immune ..
- David T Evans; Fiscal Year: 2016..We recently identified Mamu-A*02, an MHC class I molecule present in approximately 20% of Indian origin rhesus macaques, as a ligand for Mamu-KIR3DL05 (3DL05)...
- Kristina De Paris; Fiscal Year: 2016..The studies will be performed in the infant rhesus macaque model of oral SIV infection...
- Interruption of maternal-fetal transmission of HIVJoseph M McCune; Fiscal Year: 2012..a multidisciplinary team has been assembled to evaluate tolerance induction in the context of the SIV-infected rhesus macaque, a well-developed model with unique similarities to human placentation and HIV infection...
- Mark E Wilson; Fiscal Year: 2016..Simian immunodeficiency virus (SIV) infection of rhesus macaques (Macaca mulatta) is the most effective pre-clinical model of HIV infection...
- Louis J Picker; Fiscal Year: 2016PROJECT SUMMARY (See instructions): HIV and its rhesus macaque (RM) counterpart SIV share a pattern of infection and a constellation of immunologic and pathobiologic features such that the vast majority of susceptible (untreated) people ..
- George M Shaw; Fiscal Year: 2015..Genetically-diverse, rhesus macaque-adapted, pathogenic SIVsmm viruses will productively infect Indian rhesus macaques by atraumatic penile inoculation and lead to persistent replication and pathogenicity...
- Synergy between SIV & Salmonella InfectionANDREAS J BAUMLER; Fiscal Year: 2010..The objectives of this application are to use a simian immunodeficiency virus (SIV)/NTS Rhesus macaque model to determine how the innate immune response to Salmonella is altered in HIV patients.
- TRICIA HELEN BURDO; Fiscal Year: 2016..In this application, we will use a SIV rhesus macaque model of AIDS to determine if: 1) continual monocyte traffic to DRGs drives peripheral neuropathy pathogenesis ..
- MINH HIEN TRUONG DINH; Fiscal Year: 2014..My next aim is to study HIV sexual transmission using the male rhesus macaque model...
- Carlos A Sariol; Fiscal Year: 2015..will be donated by CPRC and will consist of approximately 1,120 SPF (Herpes B, STLV-1, SIV and SRV-free) rhesus macaques. About 82 (7%) of the U24 SPF animals will be also free of the papovavirus SV40...
- Project 1: Immunogens and ManufacturingHarriet L Robinson; Fiscal Year: 2012..to express full length Env that we have found to prime the most protective antibody responses using the SIV rhesus macaque model (see Program Overview)...
- Establishment &maintenance of a closed CPRC SPF colonyEDMUNDO NELSON KRAISELBURD; Fiscal Year: 2011..monkeys donated by CPRC will consist of approximately 755 SPF (Herpes B, STLV-1, SIV and SRV-free) rhesus macaques of which 164 (or 22%) will also be free of the papova virus SV40...
- Targeting regulators of cellular gene transcription to impact HIV latencyDouglas D Richman; Fiscal Year: 2010..lymphocytes obtained ex vivo from chronically infected, HAART-suppressed patients (project 2), and (3) an SIV/Rhesus macaque model (Project 1). Latent infection will be quantified by the two scientific cores...
- Ashley T Haase; Fiscal Year: 2015..We recently discovered in the SIV-rhesus macaque model of HIV-1 transmission to women that mucosal antibodies to oligomeric gp41 are the principal correlate of ..
- Carlos A Sariol; Fiscal Year: 2015..monkeys donated by CPRC will consist of approximately 755 SPF (Herpes B, STLV-1, SIV and SRV-free) rhesus macaques of which 164 (or 22%) will also be free of the papova virus SV40...
- Toward an HIV-1 macaque modelJason T Kimata; Fiscal Year: 2010..While SIV infection of rhesus macaques is a heavily utilized and important surrogate model for investigating relevant concepts in HIV-1 pathogenesis ..
- Cervical/Vaginal Mucus and MicrobicidesThomas Hope; Fiscal Year: 2012..In the second phase (R33) of this proposal we will extend our studies into the environment of the rhesus macaque female genital tract to determine how biological fluids and microbicide vehicles alter the way that virus ..
- Thomas Hope; Fiscal Year: 2015..In the second phase (R33) of this proposal we will extend our studies into the environment of the rhesus macaque female genital tract to determine how biological fluids and microbicide vehicles alter the way that virus ..
- Modulation of the early host response to SIV in pathogenic infectionAmitinder Kaur; Fiscal Year: 2013..In recent studies we have shown that acute events following SIV infection in rhesus macaques (RM) differ from those occurring in the natural host sooty mangabeys (SM) with regards to the presence of CD4+..
- Welkin E Johnson; Fiscal Year: 2015..Aim);and 3) generate rationally designed HIV-1 strains capable of robust replication in primary cells of rhesus macaques representing all common TRIM5 genotypes (third Specific Aim)...
- ENHANCEMENT OF THE CPRC-SPF RHESUS MONKEY PROGRAM: AIDS GENOMEEDMUNDO NELSON KRAISELBURD; Fiscal Year: 2011..About 20-25% of these monkeys are also Mamu-A*01 positive. Currently, there is a shortage of SPF rhesus monkeys for biomedical research and the demand for these animals is expected to increase dramatically in the future...
- Michael K Axthelm; Fiscal Year: 2015..of the ONPRC AIDS Research Expanded SPF Breeding Colony to provide genetically characterized lndian-origln rhesus macaques free of a broad number of enzootic and zoonotic agents to enhance the usefulness of the resource for cutting ..
- MHC characterization in Chinese rhesus macaquesBIANCA ROMINA MOTHE; Fiscal Year: 2013..We will determine if HLA analogy extends to cellular reactivity by testing cells from AIDS- infected Chinese rhesus macaques expressing specific alleles of interest...
- CD8+ T cell effector transcriptional programming in SIV infectionMichael R Betts; Fiscal Year: 2013..Here, we will address these concepts in the rhesus macaque model in order to address two hypotheses: 1) we hypothesize that high T- bet expression by SIV/HIV-1 specific ..
- PD-1 blockade as a therapy for SIV/AIDSRama Rao Amara; Fiscal Year: 2011..improve the therapeutic potential of in vivo PD-1 blockade to treat chronic HIV infection using the SIV/rhesus macaque model. We propose to use three approaches...
- CHRISTOPHER JAMES MILLER; Fiscal Year: 2015..the impact of pH and low concentrations of antibody on transmission efficiency following penile exposure of rhesus macaques to SIV...
- Thomas Hope; Fiscal Year: 2015..suggest that the system can be utilized to identify transduced target cells after vaginal exposure in female rhesus macaques. We believe that the rhesus macaque is currently the most widely used and perhaps most relevant model ..
- Early Events in Mucosal SIV PathogenesisRonald S Veazey; Fiscal Year: 2013..CD4+ T cells in acutely infected macaques in vivo, and;3) Identify the mechanisms of control of SIV in rhesus macaques infected with pathogenic SIV by comparing immunologic changes in mucosal and systemic tissue compartments ..
- Drew Weissman; Fiscal Year: 2014..to test the effect of blocking gp340 and syndecan-HIV Env interaction on genital tract SIV transmission in the rhesus macaque vaginal transmission model...
- Michael D George; Fiscal Year: 2014..microbial signature of intestinal dysbiosis and the mechanisms of its role in enteropathy in the SIV infected rhesus macaque model...
- Gp340 and syndecan inhibition based microbicide for HIVDrew Weissman; Fiscal Year: 2010..to test the effect of blocking gp340 and syndecan-HIV Env interaction on genital tract SIV transmission in the rhesus macaque vaginal transmission model...
- Patricia E Molina; Fiscal Year: 2016..Collectively, these factors contribute to the transmission of HIV. In previous studies using the alcohol-fed rhesus macaques infected with Simian Immunodeficiency Virus (SIV), we have shown that chronic alcohol use is associated with ..
- Interaction of HIV with Macaque Genital TractANN M CARIAS; Fiscal Year: 2012..The most characterized of these systems is the rhesus macaque model using SIV modified to use the HIV envelope protein (SHIV)...
- Mechanisms of protection from, and enhanced susceptibility to, HIV infection afteCHRISTOPHER JAMES MILLER; Fiscal Year: 2010..trials is first to model the results of the trial in controlled experiments using mucosal SIV inoculation of rhesus macaques. Thus, we will determine the effectiveness and potential of the Merck trivalent HIV adenovirus 5 vector ..
- Impact of Extraordinarily Large Numbers of SIV-specific CD8 T Cells on Vaginal TrDavid Masopust; Fiscal Year: 2013..This proposal will test in the SIV-rhesus macaque model of HIV-1 transmission to women the concept that extraordinarily large numbers of SIV-specific CTLs ..
- Interacting Impact of Adrenal and Ovarian Aging on the CNSHenryk F Urbanski; Fiscal Year: 2011..We have already shown that female rhesus macaques, like women, undergo menopause, and that a change in plasma FSH and inhibin B levels represents the first ..
- RNA interference therapy for Huntington's disease: studies in non-human primatesBeverly L Davidson; Fiscal Year: 2010..With these tools we can now answer the questions posed in a more relevant model, the normal NHP (rhesus macaque;Macaca mullata)...
- Jin Billy Li; Fiscal Year: 2016..We will use this approach to extend our analysis to RNA editing in other primates such as chimpanzees and rhesus macaque monkeys, with the expectation of uncovering the contributions of RNA editing to conserved functions as well as ..
- Neuroendocrine Response to Gastric Bypass in Nonhuman PrimatesRandy J Seeley; Fiscal Year: 2010..The aims of the project are (1) to establish a model of RYGB in obese Rhesus macaques and to characterize its effects on food intake, ingestive behavior, food preference and energy expenditure, ..
- GENETIC RESOURCES FOR NON-HUMAN PRIMATESLeslie Lyons; Fiscal Year: 2007..b>Rhesus macaques and baboons are the animal models that most closely resemble humans, biologically, physiologically, and ..
- Immunogenetic characterization of MHC molecules as a tool for biomedical researchAlessandro Sette; Fiscal Year: 2007b>Rhesus macaques (Macaca mulatta) and Cynomolgus macaques (Macaca fascicularis), are widely used as models of disease pathogenesis in humans and for evaluating vaccines and therapeutics against microbial pathogens, including emerging ..
- ENTERIC VIRAL INFECTIONS OF CAPTIVE RHESUS MACAQUESKarol Sestak; Fiscal Year: 2009..of rotaviruses and enteric caliciviruses that are associated with GI disease in the TNPRC breeding colony rhesus macaques. Aim 2: Experimentally reproduce symptomatic rota- and calicivirus infection in seronegative rhesus macaques...
- SPECIFIC PATHOGEN FREE MACAQUE BREEDING PROGRAMM Izard; Fiscal Year: 1999..The further discovery that when SIV is transinfected into seronegative rhesus macaques, they develop clinical pathogenesis of HIV/AIDS in humans, has provided a research tool of unparalleled ..
- RELATION BETWEEN SPACE AND AGGRESSION IN RHESUS MACAQUESFrans De Waal; Fiscal Year: 1992Research institutions have recently come under attack for trauma in their rhesus monkeys (Macaca mulatta). The fighting is blamed on crowded housing conditions...
- Conference Support: NHP Models of AgingJoseph Kemnitz; Fiscal Year: 2001..Because the vast majority of research in this area has been conducted in rhesus monkeys (Macaca mulatta), the entire second day will focus exclusively on studies using this species- The morning ..
- Safety signal learning in Rhesus monkeys following early life stressChallenge ArMICHAEL NMN DAVIS; Fiscal Year: 2010..We have now developed in rats, rhesus monkeys and humans an objective measure of safety signal learning and expression using identical paradigms and the ..
- Macaque model of TB/AIDS co-infection via natural routes of exposureDeepak Kaushal; Fiscal Year: 2010..It has been possible to model AIDS extremely well in rhesus macaques infected with Simian immune Virus (SIV)...
- MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASEMady Hornig; Fiscal Year: 2002..neonatal rats have been described, nonhuman primate studies have been pursued only in acutely infected adult rhesus macaques. Studies proposed here will clarify whether primates can be infected in the perinatal period and, if so, ..
- Restoration of Dopaminergic Function in Parkinson's DiseaseGreg Gerhardt; Fiscal Year: 2009..yielded controversial data regarding potential GDNF antibody formation and preliminary toxicology studies in rhesus monkeys support a potential toxicity of GDNF to cerebellar Purkinje cells and granule cells, when chronically ..
- MaqFACS: Measuring expressive movement in monkeysLisa Parr; Fiscal Year: 2009..This project will develop a rigorous, objective and standardized tool for quantifying facial movement in the rhesus monkey, the species used most widely as a model for human biobehavioral, neurobiological, and affective disorders...
- Primate Endometrial Responses to Placental MHC Class I MoleculesThaddeus Golos; Fiscal Year: 2009..demonstrated the biological relevance of primate placental MHC class I expression with passive immunization of rhesus monkeys during early pregnancy...
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