Genomes and Genes
Alias: dogs, Canis familiaris, beagle dog, beagle dogs, Canis canis, Canis domesticus, Canis lupus familiaris
Publications385 found, 100 shown here
- Genome sequence, comparative analysis and haplotype structure of the domestic dogKerstin Lindblad-Toh
Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, USA
Nature 438:803-19. 2005Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds...
- A single IGF1 allele is a major determinant of small size in dogsNathan B Sutter
National Human Genome Research Institute, Building 50, Room 5349, 50 South Drive MSC 8000, Bethesda, MD 20892 8000, USA
Science 316:112-5. 2007..We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size...
- A molecular network for de novo generation of the apical surface and lumenDavid M Bryant
Department of Anatomy, University of California, San Francisco, CA 94143 2140, USA
Nat Cell Biol 12:1035-45. 2010..This Rab11a-directed network directs Cdc42-dependent apical exocytosis during lumen formation, revealing an interaction between the machineries of vesicular transport and polarization...
- Molecular origins of rapid and continuous morphological evolutionJohn W Fondon
Eugene McDermott Center for Human Growth and Development and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
Proc Natl Acad Sci U S A 101:18058-63. 2004..Here, we describe a comparative genomic study of repetitive elements in developmental genes of 92 breeds of dogs. We find evidence for selection for divergence at coding repeat loci in the form of both elevated purity and ..
- PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humansAnaïs Grall
Centre National de la Recherche Scientifique, Institut de Génétique et Développement de Rennes, Rennes, France
Nat Genet 44:140-7. 2012..insertion-deletion (indel) mutation in PNPLA1 that leads to a premature stop codon in all affected golden retriever dogs. We subsequently found one missense and one nonsense mutation in the catalytic domain of human PNPLA1 in six ..
- The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctionsRie Yamamura
Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
Mol Biol Cell 19:971-83. 2008..These results suggest that the interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of AJs and TJs...
- Density of tumor-associated macrophages (TAMs) and expression of their growth factor receptor MCSF-R and CD14 in canine mammary adenocarcinomas of various grade of malignancy and metastasisM Krol
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences WULS, Nowoursynowska 159, 02 776 Warsaw, Poland
Pol J Vet Sci 14:3-10. 2011..studies on tumor associated macrophages and the role of the tumor microenvironment in tumor invasion/metastasis in dogs. This is the first study performed to asses if the number of TAMs and expression of MCSF-R (macrophages colony ..
- Caveolin-1 and -2 in the exocytic pathway of MDCK cellsP Scheiffele
Cell Biology Programme, European Molecular Biology Laboratory, D 69012 Heidelberg, Germany
J Cell Biol 140:795-806. 1998..Thus, we suggest that caveolin-1 homooligomers play a role in apical transport...
- Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humansNoa Safra
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, USA
PLoS Genet 9:e1003646. 2013..The variable conditions associated with NTDs occur naturally in dogs, and have been previously reported in the Weimaraner breed...
- Assessment of canine BEST1 variations identifies new mutations and establishes an independent bestrophinopathy model (cmr3)Barbara Zangerl
Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Mol Vis 16:2791-804. 2010..a group of retinal disorders known as bestrophinopathies in man and canine multifocal retinopathies (cmr) in the dog. To date, the dog is the only large animal model suitable for the complex characterization and in-depth studies of ..
- Gain-of-function mutations in the extracellular domain of KIT are common in canine mast cell tumorsSébastien Letard
Institut National de la Sante et de la Recherche Medicale, U891, Centre de Recherche en Cancerologie de Marseille, Molecular and Functional Hematopoiesis, Marseille F 13009, France
Mol Cancer Res 6:1137-45. 2008In the current study, we examined the types and frequency of KIT mutations in mast cell tumors from 191 dogs. Sequencing of reverse transcription-PCR products revealed alterations in 50 (26.2%) of the dogs...
- Mucosal imbalance of interleukin-1β and interleukin-1 receptor antagonist in canine inflammatory bowel diseaseShingo Maeda
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Vet J 194:66-70. 2012..expression of IL-1β and IL-1Ra mRNA by real-time RT-PCR and expression of IL-1β and IL-1Ra protein by ELISA in 21 dogs with IBD, 15 dogs with intestinal lymphoma ('inflammatory' controls) and 20 healthy Beagles ('healthy' controls)...
- Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cellsRita L Nokes
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
J Cell Biol 182:845-53. 2008..Importantly, proteins using a direct route from the TGN to the plasma membrane are not affected. Thus, Rab13 appears to regulate membrane trafficking between TGN and RE...
- Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutationKeiko Miyadera
Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom
Mol Vis 15:2287-305. 2009..1 (cord1), a recessive form of progressive retinal atrophy (PRA) in the Miniature Longhaired Dachshund (MLHD), a dog model for Leber congenital amaurosis...
- Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signalingDavid Cohen
The Margaret Dyson Institute of Vision Research, Weill Medical College of Cornell University, New York, NY 10021, USA
Mol Biol Cell 18:2203-15. 2007..E-cadherin depletion also reverted the hepatic-type intracellular luminal compartment in Par1b-MDCK cells to VACs characteristic of control MDCK cells, indicating a novel link between E-cadherin and luminal protein targeting...
- Expression and significance of PTEN and VEGF in canine mammary gland tumoursC W Qiu
College of Veterinary Medicine, China Agricultural University, Beijing, People s Republic of China
Vet Res Commun 32:463-72. 2008..Reduced expression of PTEN might be involved in carcinogenesis and progression of canine breast cancer by up-regulating the VEGF expression to enhance angiogenesis...
- Rab11 is required for trans-golgi network-to-plasma membrane transport and a preferential target for GDP dissociation inhibitorW Chen
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
Mol Biol Cell 9:3241-57. 1998..These data show that functional rab11 is critical for the export of a basolateral marker but not an apical marker from the trans-Golgi network and pinpoint rab11 as a sensitive target for inhibition by excess GDI...
- Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3Duska J Sidjanin
Center for Canine Genetics and Reproduction, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Hum Mol Genet 11:1823-33. 2002..A deletion removing all exons of canine CNGB3 was identified in cd-affected Alaskan Malamute-derived dogs. A missense mutation in exon 6 (D262N, nucleotide 784) within a conserved region of the same gene was detected in ..
- Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epitheliaAlan S Fanning
Department of Cell and Molecular Physiology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, USA
Mol Biol Cell 23:577-90. 2012....
- Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levelsChristopher Boehlke
Renal Unit, University Medical Center, University of Freiburg, Hugstetter Strasse 55, Freiburg 79106, Germany
J Cell Sci 123:1460-7. 2010..Depletion of Rab23 or expression of dominant-negative Rab23 decreased the ciliary steady state specifically of Smoothened but not EB1 or Kim1, suggesting a role of Rab23 in protein turnover in the cilium...
- A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogsMia Olsson
Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
PLoS Genet 7:e1001332. 2011..A similar periodic fever syndrome is relatively frequent in the Chinese Shar-Pei breed of dogs. In the western world, Shar-Pei have been strongly selected for a distinctive thick and heavily folded skin...
- Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cellsChristopher T Capaldo
Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908 0577, USA
Mol Biol Cell 18:189-200. 2007....
- Localization of canine brachycephaly using an across breed mapping approachDanika Bannasch
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
PLoS ONE 5:e9632. 2010The domestic dog, Canis familiaris, exhibits profound phenotypic diversity and is an ideal model organism for the genetic dissection of simple and complex traits...
- A brain serine/threonine protein kinase activated by Cdc42 and Rac1E Manser
Institute of Molecular and Cell Biology, National University of Singapore, Kent Ridge
Nature 367:40-6. 1994..This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways...
- Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartmentsP Chavrier
European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
Cell 62:317-29. 1990..These findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells...
- cGMP phosphodiesterase-alpha mutation causes progressive retinal atrophy in the Cardigan Welsh corgi dogS M Petersen-Jones
The Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, United Kingdom
Invest Ophthalmol Vis Sci 40:1637-44. 1999To screen the alpha-subunit of cyclic guanosine monophosphate (cGMP) phosphodiesterase (PDE6A) as a potential candidate gene for progressive retinal atrophy (PRA) in the Cardigan Welsh corgi dog.
- Identification of a new copper metabolism gene by positional cloning in a purebred dog populationBart van De Sluis
Department of Medical Genetics, KC04 084 2, University Medical Centre Utrecht, WKZ, Lundlaan 6, 3584 EA Utrecht, The Netherlands
Hum Mol Genet 11:165-73. 2002Domesticated animal species such as dogs and cats, with their many different characteristics and breed-specific diseases, and their close relationship and shared environment with humans, are a potentially rich source for the ..
- Immunohistochemical expression of Epidermal Growth Factor Receptor (EGFR) in canine mammary tissuesA Gama
Department of Veterinary Sciences, CECAV, University of Trás os Montes and Alto Douro UTAD, 5001 811 Vila Real, Portugal
Res Vet Sci 87:432-7. 2009..On survival analysis, tumours with EGFR overexpression showed a reduced disease-free and overall survival; however these associations failed to reach statistically significant levels...
- Canine Lat1: molecular structure, distribution and its expression in cancer samplesHideharu Ochiai
Research Institute of Biosciences, Azabu University, School of Veterinary Medicine, 1 17 71 Fuchinobe, Chuou ku, Sagamihara, Kanagawa 252 5201, Japan
J Vet Med Sci 74:917-22. 2012..Notably, Lat1 expression was observed in the tissues of thyroid cancer, melanoma and hemangiopericytoma. Although the cancer samples examined were not enough, Lat1 may serve as a useful biomarker of cancer cells in veterinary clinic...
- A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathyCamilla S Bruun
Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark
PLoS ONE 8:e54547. 2013..Affected dogs were of both sexes and were ambulatory paraparetic, progressing to non-ambulatory tetraparesis...
- Genome-wide analysis in German shepherd dogs reveals association of a locus on CFA 27 with atopic dermatitisKatarina Tengvall
Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
PLoS Genet 9:e1003475. 2013Humans and dogs are both affected by the allergic skin disease atopic dermatitis (AD), caused by an interaction between genetic and environmental factors. The German shepherd dog (GSD) is a high-risk breed for canine AD (CAD)...
- A canine BCAN microdeletion associated with episodic falling syndromeJennifer L Gill
Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
Neurobiol Dis 45:130-6. 2012..Wider testing of a larger population of CKCS dogs without a history of EFS from the USA revealed that carriers are extremely common (12.9%)...
- Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cellsLynne A Lapierre
Section of Surgical Sciences and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Mol Biol Cell 23:2302-18. 2012..These results indicate that Ser-227 phosphorylation of Rab11-FIP2 regulates the composition of both adherens and tight junctions and is intimately involved in the regulation of polarity in epithelial cells...
- Co-operative regulation of endocytosis by three Rab5 isoformsC Bucci
Dipartimento di Biologia e Patologia Cellulare e Moleculare L Califano, Consiglio Nazionale delle Ricerche, Napoli, Italy
FEBS Lett 366:65-71. 1995..These data demonstrate that three Rab5 isoforms cooperate in the regulation of endocytosis in eukaryotic cells...
- Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologuesY Ando-Akatsuka
Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
J Cell Biol 133:43-7. 1996..the nucleotide sequences of full length cDNAs encoding occludin of rat-kangaroo (potoroo), human, mouse, and dog. Rat-kangaroo occludin cDNA was prepared from RNA isolated from PtK2 cell culture, using a mAb against chicken ..
- Canine adiponectin: cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesityK Ishioka
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
Res Vet Sci 80:127-32. 2006..Adiponectin mRNA was detected in adipose tissues, but not in other tissues, of dogs. When 22 adult beagles were given a high-energy diet for 14 weeks, they became obese, showing heavier body weights, ..
- The role of c-KIT in tumorigenesis: evaluation in canine cutaneous mast cell tumorsJoshua D Webster
Comparative Medicine and Integrative Biology Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
Neoplasia 8:104-11. 2006..Cutaneous MCTs are common neoplasms in dogs and have a variable biologic behavior...
- Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscleReinoud Gosens
Department of Physiology, University of Manitoba, John Buhler Research Centre, Winnipeg, Manitoba, Canada
Am J Physiol Lung Cell Mol Physiol 293:L1406-18. 2007..These results indicate caveolae and caveolin-1 facilitate [Ca(2+)](i) mobilization leading to ASM contraction induced by submaximal concentrations of ACh...
- A frameshift mutation in golden retriever dogs with progressive retinal atrophy endorses SLC4A3 as a candidate gene for human retinal degenerationsLouise M Downs
Canine Genetics, Animal Health Trust, Newmarket, United Kingdom
PLoS ONE 6:e21452. 2011Progressive retinal atrophy (PRA) in dogs, the canine equivalent of retinitis pigmentosa (RP) in humans, is characterised by vision loss due to degeneration of the photoreceptor cells in the retina, eventually leading to complete ..
- Parallel mapping and simultaneous sequencing reveals deletions in BCAN and FAM83H associated with discrete inherited disorders in a domestic dog breedOliver P Forman
Kennel Club Genetics Centre, Animal Health Trust, Kentford, United Kingdom
PLoS Genet 8:e1002462. 2012The domestic dog (Canis familiaris) segregates more naturally-occurring diseases and phenotypic variation than any other species and has become established as an unparalled model with which to study the genetics of inherited traits...
- A SEL1L mutation links a canine progressive early-onset cerebellar ataxia to the endoplasmic reticulum-associated protein degradation (ERAD) machineryKaisa Kyöstilä
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
PLoS Genet 8:e1002759. 2012..Hereditary ataxias occur in many species, including humans and dogs. Several mutations have been found in humans, but the genetic background has remained elusive in dogs...
- CSF-1R as an inhibitor of apoptosis and promoter of proliferation, migration and invasion of canine mammary cancer cellsMagdalena Król
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences WULS, Nowoursynowska 159, Warsaw, 02 776, Poland
BMC Vet Res 9:65. 2013..As far as we know, the study presented hereby is a pioneering experiment in this field of veterinary medicine...
- Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumoursJ M Bush
IDEXX Laboratories, Memphis, TN, USA
Int J Androl 34:e288-95; discussion e295. 2011..To compare testicular germ cell tumours (TGCT) in dogs with those of men, archived tissues from 347 cases of canine testicular tumours were morphologically evaluated and ..
- Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assemblyMeng He
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 287:43995-4005. 2012....
- Cloning and sequencing full length of canine Brca2 and Rad51 cDNAK Ochiai
Laboratories of Veterinary Physiology, Faculty of Agriculture, Iwate University, Morioka, Japan
J Vet Med Sci 63:1103-8. 2001Mammary tumors are the most common neoplasm in female dogs, Canis canis, and in women. Mutations in human Brca2 confer an increased risk of female breast cancer...
- A mutation in canine CLN5 causes neuronal ceroid lipofuscinosis in Border collie dogsScott A Melville
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Genomics 86:287-94. 2005Neuronal ceroid lipofuscinosis (NCL) is a neurodegenerative disease found in Border collie dogs, humans, and other animals. Disease gene studies in humans and animals provided candidates for the NCL gene in Border collies...
- Analysis of genetic variations in the exon 27 region of the canine BRCA2 locusYasunaga Yoshikawa
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan
J Vet Med Sci 67:1013-7. 2005Mammary tumors are the most common tumor type in women as well as in female dogs. The BRCA2 gene encodes a large nuclear protein that is involved in DNA repair, and mutations in the human BRCA2 confer an increased risk of female mammary ..
- Novel variations and loss of heterozygosity of BRCA2 identified in a dog with mammary tumorsYasunaga Yoshikawa
Laboratory of Cytology and Histology, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
Am J Vet Res 69:1323-8. 2008To establish novel polymorphic markers for analysis of loss of heterozygosity (LOH), so as to study the possible involvement of BRCA2 in mammary tumors obtained from dogs.
- Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanismMark Hilge
Protein Biophysics, Institute for Molecules and Materials, Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands
Proc Natl Acad Sci U S A 106:14333-8. 2009..In contrast to CBD1, the electrostatic switch in CBD2 is isoform- and splice variant-specific and allows for tailored exchange activities...
- Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeatsK Ochiai
Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
Vet J 190:293-5. 2011..These results may provide an insight into the effects of missense or truncation mutations in BRCA2 in canine tumours...
- Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimersScott A John
Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1751, USA
Proc Natl Acad Sci U S A 108:1699-704. 2011..FRET studies of CBD1, CBD2, and CBD1-CBD2 peptides displayed Ca(2+)-dependent movements with different apparent affinities. CBD1-CBD2 showed a Ca(2+)-dependent phenotype mirroring full-length NCX but distinct from both CBD1 and CBD2...
- Characterization of β-catenin expression in canine osteosarcomaT J Stein
Department of Medical Science, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706 1102, USA
Vet Comp Oncol 9:65-73. 2011Osteosarcoma (OSA) is the most frequently occurring malignant primary bone tumour in dogs and children and arises from cells of the osteoblast lineage. Inappropriate Wnt signalling activity has been implicated in human OSA...
- Breed-independent toll-like receptor 5 polymorphisms show association with canine inflammatory bowel diseaseA Kathrani
Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, London, UK
Tissue Antigens 78:94-101. 2011Inflammatory bowel disease (IBD) is thought to be the most common cause of vomiting and diarrhoea in dogs. Although IBD can occur in any canine breed, certain breeds are more susceptible...
- Characterization of candidate genes for neuronal ceroid lipofuscinosis in dogC Drogemuller
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bunteweg 17p, 30559 Hannover, Germany
J Hered 96:735-8. 2005..NCL has also been reported in various domestic animal species including cattle, goat, sheep, cat, and certain dog breeds...
- Canine RD3 mutation establishes rod-cone dysplasia type 2 (rcd2) as ortholog of human and murine rd3Anna V Kukekova
James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Hungerford Hill Road, Ithaca, New York 14853, USA
Mamm Genome 20:109-23. 2009Rod-cone dysplasia type 2 (rcd2) is an autosomal recessive disorder that segregates in collie dogs. Linkage disequilibrium and meiotic linkage mapping were combined to take advantage of population structure within this breed and to fine ..
- Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysisEnio Ferreira
Department of Pathology, Biological Sciences Institute, Federal University of Minas Gerais, Av Antonio Carlos, 6627, Belo Horizonte, Minas Gerais, 31270 901, Brazil
BMC Cancer 10:61. 2010..They have not previously been described in canine mammary gland. The aim of this paper is describe the morphologic spectrum of columnar cell lesions in canine mammary gland specimens and their association with other breast lesions...
- A canine Arylsulfatase G (ARSG) mutation leading to a sulfatase deficiency is associated with neuronal ceroid lipofuscinosisMarie Abitbol
Unité Mixte de Recherche 955 de Génétique Fonctionnelle et Médicale, Institut National de la Recherche Agronomique, and Unité Propre de Recherche de Neurobiologie, Universite Paris Est, Ecole Nationale Veterinaire d Alfort, F 94700 Maisons Alfort, France
Proc Natl Acad Sci U S A 107:14775-80. 2010..a late-onset form of NCL recessively segregates in US and French pedigrees of American Staffordshire Terrier (AST) dogs. Through combined association, linkage, and haplotype analyses, we mapped the disease locus to a single region of ..
- ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludinJ Haskins
Department of Cell Biology and Anatomy, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
J Cell Biol 141:199-208. 1998..In vitro affinity analyses demonstrated that recombinant 130-kD protein directly interacts with ZO-1 and the cytoplasmic domain of occludin, but not with ZO-2. We propose that this protein be named ZO-3...
- Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeabilityGaelle Benais-Pont
Department of Cell Biology, University of Geneva, 1211 Geneva, Switzerland
J Cell Biol 160:729-40. 2003..These data indicate that GEF-H1/Lfc is a component of TJs and functions in the regulation of epithelial permeability...
- Matrix metalloproteinase 13 (MMP13) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1), regulated by the MAPK pathway, are both necessary for Madin-Darby canine kidney tubulogenesisNathan E Hellman
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 283:4272-82. 2008..These data suggest a model, which may also be important for development of other branched organs, whereby the MAPK pathway controls both MDCK p-EMT and redifferentiation, in part by activating MMP13 and TIMP1...
- Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucomaJohn Kuchtey
Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
PLoS Genet 7:e1001306. 2011..In this study, we used genome-wide SNP arrays to map the disease gene in a colony of Beagle dogs with inherited POAG to within a single 4 Mb locus on canine chromosome 20...
- VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesiclesT V Kurzchalia
Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
J Cell Biol 118:1003-14. 1992..The transiently expressed protein appeared on the Golgi-apparatus, the plasma membrane and vesicular structures. We propose that VIP21 is a component of the molecular machinery of vesicular transport...
- Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolaeD J Dietzen
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
J Biol Chem 270:6838-42. 1995..Thus, palmitoylation of cysteine residues in nonmembrane spanning Src family protein tyrosine kinases has different consequences than in the transmembrane protein caveolin...
- The ubiquitously expressed MURR1 protein is absent in canine copper toxicosisAdriana E M Klomp
Department of Metabolic and Endocrinic Diseases, University Medical Center Utrecht, room KC02 069 1, Utrecht University, Lundlaan 6, 3584 EA Utrecht, The Netherlands
J Hepatol 39:703-9. 2003..is an autosomal recessive disorder characterized by massive lysosomal copper accumulation in livers of affected dogs, and a defect in the biliary excretion of this metal...
- Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinM Furuse
Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
J Cell Biol 141:1539-50. 1998....
- Caveolae and sorting in the trans-Golgi network of epithelial cellsP Dupree
Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
EMBO J 12:1597-605. 1993..This connection is confirmed by the recent finding that the amino acid sequence of VIP21 is almost identical to that of caveolin, a protein previously localized to caveolae...
- E-cadherin dis-engagement activates the Rap1 GTPaseSirisha Asuri
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine and Walther Oncology Center, Indianapolis, Indiana 46202, USA
J Cell Biochem 105:1027-37. 2008..We hereby show that Rap1 plays a role in the maintenance and repair of E-cadherin junctions and is activated via an "outside-in" signaling pathway initiated by E-cadherin and mediated at least in part by PDZ-GEF I...
- Mammary tumor development in dogs is associated with BRCA1 and BRCA2Patricio Rivera
Department of Clinical Sciences, Division of Small Animal Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden
Cancer Res 69:8770-4. 2009..single-nucleotide polymorphisms (SNPs; four to nine SNPs per gene) were genotyped by iPLEX in female ESS dogs, 212 CMT cases and 143 controls...
- A truncated retrotransposon disrupts the GRM1 coding sequence in Coton de Tulear dogs with Bandera's neonatal ataxiaR Zeng
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
J Vet Intern Med 25:267-72. 2011Bandera's neonatal ataxia (BNAt) is an autosomal recessive cerebellar ataxia that affects members of the Coton de Tulear dog breed.
- Genome-wide association analysis identifies a mutation in the thiamine transporter 2 (SLC19A3) gene associated with Alaskan Husky encephalopathyKaren M Vernau
University of California Davis, Davis, California, United States of America
PLoS ONE 8:e57195. 2013..We studied 11 Alaskan Husky dogs with AHE, but found no abnormalities in respiratory chain enzyme activities in muscle and liver, or mutations in ..
- Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasmsY Ma
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Invest Dermatol 112:165-70. 1999..the development of mast cell neoplasms, we examined canine mastocytomas, which are among the most common tumors of dogs and which often behave in a malignant fashion, unlike human solitary mastocytomas...
- Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kitC A London
Department of Pathology, Brigham and Women s Hospital, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Exp Hematol 27:689-97. 1999Spontaneous mast cell tumors (MCT) are the most common malignant neoplasm in the dog, representing between 7% and 21% of all canine tumors, an incidence much higher than that found in humans...
- Canine TCOF1; cloning, chromosome assignment and genetic analysis in dogs with different head typesK E Haworth
MRC Human Biochemical Genetics Unit, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
Mamm Genome 12:622-9. 2001..Genetic analysis of DNA of dogs from 13 different breeds identified nine DNA sequence variants, three of which gave rise to amino acid ..
- Evaluation of the kinase domain of c-KIT in canine cutaneous mast cell tumorsJoshua D Webster
Comparative Medicine and Integrative Biology Program, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA
BMC Cancer 6:85. 2006..However, some canine MCTs have aberrant KIT localization but lack ITD c-KIT mutations, suggesting that other mutations or other factors may be responsible for aberrant KIT localization in these tumors...
- A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migrationChau Zen Wang
Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan 701, Taiwan
Mol Biol Cell 17:2839-52. 2006..Together, these results demonstrate that SHP-2 is required for the DDR1-induced suppression of Stat1 and Stat3 tyrosine phosphorylation, cell migration, and branching tubulogenesis...
- Characterization of the canine 3beta-hydroxysteroid dehydrogenase and its expression in the corpus luteum during diestrusM P Kowalewski
Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus Liebig University, Giessen, D 35392 Giessen, Germany
J Steroid Biochem Mol Biol 101:254-62. 2006..Objectives of the present study were to clone canine 3betaHSD and to investigate its expression in dog corpora lutea (CL) covering the periods of their formation, early and late regression (days 5, 15, 25, 35, 45, 65 ..
- Genes affecting coat colour and pattern in domestic dogs: a reviewS M Schmutz
Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK, Canada S7N 5A8
Anim Genet 38:539-49. 2007Tremendous progress has been made in identifying genes involved in pigmentation in dogs in the past few years. Comparative genomics has both aided and benefited from these findings...
- Immunohistochemical expression of p63 and deltaNp63 in mixed tumors of canine mammary glands and its relation with p53 expressionA C Bertagnolli
Laboratory of Comparative Pathology, Depto De Patologia Geral ICB UFMG Cx postal 486, CEP 31270 901, Brazil
Vet Pathol 46:407-15. 2009..Our data support the notion that the decrease of p63 expression, in particular of its isoform DeltaNp63, seems to be an important factor in the development of carcinomas in mixed tumors...
- The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumorsR Klopfleisch
Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163, Berlin, Germany
Vet Pathol 47:446-54. 2010..This pilot study identified a complex mRNA expression pattern of 3 genes that was able to identify malignancy in laser-microdissected tumor cells for each individual tumor, instead of group means as used in previous studies...
- EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contactsKoichi Miura
Department of Molecular Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
Mol Biol Cell 20:1949-59. 2009....
- Leptin, adiponectin and serotonin levels in lean and obese dogsHyung Jin Park
Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, South Korea
BMC Vet Res 10:113. 2014..The aim of this study was to find any differences in leptin, adiponectin, and 5HT between lean and obese dogs and to identify correlations among these factors.
- Canine mitochondrial uncoupling proteins: structure and mRNA expression of three isoforms in adult beaglesKatsumi Ishioka
Laboratory of Biochemistry, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, 060 0818, Sapporo, Japan
Comp Biochem Physiol B Biochem Mol Biol 131:483-9. 2002..In the present study, nucleotide and amino acid sequences of UCPs 1, 2 and 3 of a dog were determined, and their mRNA expression in various peripheral tissues was examined...
- The genetics of cream coat color in dogsSheila M Schmutz
Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada S7N 5A8
J Hered 98:544-8. 2007Cream dogs of several breeds require a genotype of e/e at MC1R based on 27 individuals in this study...
- A nonsense mutation in the acid α-glucosidase gene causes Pompe disease in Finnish and Swedish LapphundsEija H Seppala
Research Programs Unit, Molecular Medicine, University of Helsinki, Helsinki, Finland
PLoS ONE 8:e56825. 2013..This glycogen storage disease type II has been reported also in Swedish Lapphund dogs. Here we describe the genetic defect in canine Pompe disease and show that three related breeds from Scandinavia ..
- A missense mutation in the 20S proteasome β2 subunit of Great Danes having harlequin coat patterningLeigh Anne Clark
Department of Genetics and Biochemistry, College of Agriculture, Forestry, and Life Sciences, Clemson University, Clemson, SC 29634 0318, USA
Genomics 97:244-8. 2011..Described herein is the identification of a naturally-occurring mutation of the ubiquitin proteasome system that is associated with a discernable phenotype of dogs.
- Identification of a mutation in the CHAT gene of Old Danish Pointing Dogs affected with congenital myasthenic syndromeHelle Friis Proschowsky
Department of Animal and Veterinary Basic Sciences, Groennegaardsvej 3, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Denmark
J Hered 98:539-43. 2007The presence of a recessive inherited muscle disease in Old Danish Pointing Dogs has been well known for years...
- Hypermethylation of the DLC1 CpG island does not alter gene expression in canine lymphomaJeffrey N Bryan
Dept of Veterinary Medicine and Surgery, University of Missouri Columbia, 65211, USA
BMC Genet 10:73. 2009..The canine DLC1 mRNA sequence was derived from normal tissue. Using lymphoid samples from 21 dogs with NHL and 7 normal dogs, the methylation status of the promoter CpG island of the gene was defined for each ..
- A large animal model for CNGB1 autosomal recessive retinitis pigmentosaPaige A Winkler
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, United States of America
PLoS ONE 8:e72229. 2013Retinal dystrophies in dogs are invaluable models of human disease. Progressive retinal atrophy (PRA) is the canine equivalent of retinitis pigmentosa (RP). Similar to RP, PRA is a genetically heterogenous condition...
- Molecular cloning of canine protease-activated receptor-2 and its expression in normal dog tissues and atopic skin lesionsShingo Maeda
Department of Veterinary Medicine, Gifu University, Gifu, Japan
J Vet Med Sci 71:577-82. 2009..kidney, adrenal gland, spleen, thyroid gland, thymus, skeletal muscle, lymph node, fat and skin of three healthy dogs. The expression pattern of PAR-2 mRNA in canine tissues was similar to that in humans...
- Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamilyV M Olkkonen
Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
J Cell Sci 106:1249-61. 1993..Finally, rab24 was found in the endoplasmic reticulum/cis-Golgi region and on late endosomal structures. The localization of rab24 may indicate its involvement in autophagy-related processes...
- The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cellsAnne Marie Marzesco
Laboratory of Morphogenesis and Cell Signaling, UMR144 Centre National de la Recherche Scientifique CNRS, Institut Curie, Paris, France
Mol Biol Cell 13:1819-31. 2002..Our data revealed that Rab13 plays an important role in regulating both the structure and function of tight junctions...
- Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure modelStephen Zicha
Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, Quebec, Canada
Cardiovasc Res 66:472-81. 2005....
- Cloning and expression of canine CD25 for validation of an anti-human CD25 antibody to compare T regulatory lymphocytes in healthy dogs and dogs with osteosarcomaK C Rissetto
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA
Vet Immunol Immunopathol 135:137-45. 2010..by proteins expressed on the cell surface (CD4 and CD25) and inside the cell (forkhead box3 (FoxP3)), although in dogs, no anti-canine CD25 antibody exists...
- The tight junction protein ZO-2 has several functional nuclear export signalsLorenza Gonzalez-Mariscal
Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies CINVESTAV, Ave Instituto Politecnico Nacional 2508, Mexico, D F, 07360, Mexico
Exp Cell Res 312:3323-35. 2006..Moreover, the transfection of MDCK cells with full-length ZO-2 revealed that the mutation of any of the NES present in the molecule was sufficient to induce nuclear accumulation of the protein...
- Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesisJogender S Tushir
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
Mol Biol Cell 21:2355-66. 2010....
- Qualitative and quantitative immunohistochemical evaluation of iNOS expression in the spleen of dogs naturally infected with Leishmania chagasiFernando Rocha Dos Santos
Universidade Presidente Antônio Carlos, Teófilo Otoni, MG, Brazil
Parasitol Res 108:1397-403. 2011..This study aimed at evaluating immunohistochemically the iNOS expression in the spleen of dogs naturally infected (ID) with Leishmania (L.) chagasi compared with non-infected dogs (NID)...
- Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome libraryR Li
Stanford Center for Narcolepsy Research, 1201 Welch Road, Room P 112, Stanford, California 94305 5485, USA
Genomics 58:9-17. 1999..The library was hybridized with dog PCR products representing eight genes (ADA, TNFA, GCA, MYB, HOXA, GUSB, THY1, and TOP1)...
- Molecular identification of K-CL cotransporter in dog erythroid progenitor cellsHideharu Ochiai
Institute of Biosciences, School of Veterinary Medicine, Azabu University, 1 17 71 Fuchinobe, Sagamihara, Kanagawa 229 8501
J Biochem 135:365-74. 2004KCC1 cDNA was cloned in dog erythroblasts that had differentiated from peripheral mononuclear cells. The size of the cDNA was 3,258 bp, the same as in pigs, but 3 bp longer than in humans and rodents...
- A frame shift mutation in canine TPP1 (the ortholog of human CLN2) in a juvenile Dachshund with neuronal ceroid lipofuscinosisTomoyuki Awano
Department of Veterinary Pathobiology, University of Missouri College of Veterinary Medicine, Columbia, MO, USA
Mol Genet Metab 89:254-60. 2006..whereas the specific activities of 15 other lysosomal enzymes were higher than those in the brains of three control dogs. The affected Dachshund was homozygous for the mutant c...
- Polymorphism and chromosomal location of the MC4R (melanocortin-4 receptor) gene in the dog and red foxAnna Skorczyk
Department of Genetics and Animal Breeding, Agricultural University of Poznan, Poland
Gene 392:247-52. 2007..of PCR primers were designed and a search for polymorphism was performed by the SSCP technique in a group of 31 dogs representing nineteen breeds and 35 farm red foxes...
- Cellular proliferation in canine cutaneous mast cell tumors: associations with c-KIT and its role in prognosticationJ D Webster
Comparative Medicine and Integrative Biology Program, Michigan State University, Lansing, MI 48910, USA
Vet Pathol 44:298-308. 2007Canine cutaneous mast cell tumor (MCT) is a common neoplastic disease in dogs. Due to the prevalence of canine MCTs and the variable biologic behavior of this disease, accurate prognostication and a thorough understanding of MCT biology ..
- Environmental Risk Factors and Canine Malignant LymphomaElizabeth Bertone Johnson; Fiscal Year: 2005..Because canine malignant lymphoma (CML) has been established as a model for NHL and domestic dogs share their living environment with their human owners, a study of environmental exposures and CML provides a ..
- Is pet ownership associated with childhood asthma?John Henderson; Fiscal Year: 2013..A recent review of the role played by cats and dogs in the development of asthma and allergy concluded that, to date, no definitive conclusions can be drawn concerning ..
- Evaluation of Fecal Salmonella Carriage in Symptomatic and Asymptomatic Dogs in tTimothy Baszler; Fiscal Year: 2012..are qualitative and quantitative differences in fecal Salmonella colonization between symptomatic and asymptomatic dogs in the Pacific Northwest region of the USA...
- Brain Vascular Studies in Cardiac and Orthopedic SurgeryDavid Stump; Fiscal Year: 2013..We will perform MRI on six groups of dogs which simulate surgical embolic events...
- Rodney E Willoughby; Fiscal Year: 2015..TriGAS therapy will be optimized in mice, validated in dogs, and preclinically correlated with biomarkers of protective immunity in TriGAS-infected human brain tissues in ..
- Rabies virus maintenance in bat populationsAPRIL DAWN DAVIS; Fiscal Year: 2013..In the United States, large scale rabies outbreaks have been reported in other vector species such as dogs, skunks, raccoons, and foxes. However, to date, rabies outbreaks have not occurred in bat populations...
- Retroviral Vector-mediated Liver Gene Therapy for MPS IKatherine P Ponder; Fiscal Year: 2013..with an intact long-terminal repeat (LTR) expressing canine IDUA had a truly remarkable effect in both mice and dogs with MPS I, with elimination or reduction in all major clinical manifestations...
- Aquilur Rahman; Fiscal Year: 2014..and pox viruses and drug-resistant variants in vivo at doses that are non-cytotoxic in mice, rats, guinea pigs and dogs, even at doses 1000-fold higher than the therapeutic dose...
- Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteinsRishi Arora; Fiscal Year: 2013..of minigene into the PLA will be performed in order to inhibit vagally or adrenergically-mediated AF in normal dogs. In Aim 2, we propose to use these minigenes in a canine model of chronic AF;minigenes under the control of a long-..
- Michael W Brands; Fiscal Year: 2016..However, until our recent studies in dogs there was no direct evidence outside of rodent models for chronic sodium retaining or hypertensive actions of ..
- Paul J Shami; Fiscal Year: 2014..LS/MS/MS assay for measuring JS-K in biologic fluids;and 2) complete acute IV toxicology studies of JS-K in dogs and 28-day subchronic IV toxicology studies of JS-K in rats and dogs...
- Charles H Vite; Fiscal Year: 2016..We will also serve as a resource for normal dogs and cats and their tissues, and we will continue to offer a facility and expertise for investigators to perform ..
- Evaluation of Salmonella Shedding From Symptomatic and Asymptomatic PetsKristy Pabilonia; Fiscal Year: 2012..in symptomatic and asymptomatic dogs and cats, in collaboration with other Vet-LRN laboratories across the United States...
- Chymase-Mediated MMP Activation in Ishemia Reperfusion InjuryLOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013..Serial biopsy samples will be taken from the ischemic and nonischemic areas during I/R in dogs. We will study the time course of FAK dephosphorylation and activation of downstream signaling pathways ERK, JNK, ..
- Rick L Tarleton; Fiscal Year: 2016..cruzi infected dogs or cats in the home...
- John E Hall; Fiscal Year: 2016..Mechanisms in Cardiorenal Regulation;this project will use sophisticated techniques in chronically instrumented dogs to determine whether the CMS plays an important role in chronic resetting of the baroreflex and whether chronic ..
- National Center for Canine Models of Duchenne Muscular Dystrophy (NCDMD)Joe N Kornegay; Fiscal Year: 2011..Unlike the dystrophin-deficient mdx mouse, which remains relatively normal clinically, affected dogs develop progressive, fatal disease strikingly similar to the human condition...
- K777 for treatment of Chagas Disease: IND-enabling Studies and IND SubmissionRobert Don; Fiscal Year: 2012..K777 has since been shown to be efficacious in models of acute and chronic Chagas disease in both mice and dogs. K777 is non-mutagenic, has an acceptable PK profile, and has been shown to be well tolerated in animal safety ..
- Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01Lakshmi Durairaj; Fiscal Year: 2012..In a 2 week, 2 animal species study done under good laboratory practices, beagle dogs and rats tolerated inhaled xylitol well...
- Dual AAV Vectors for Duchenne Muscular Dystrophy TherapyDongsheng Duan; Fiscal Year: 2012..We have now overcome this hurdle and achieved systemic single AAV transduction in wild type newborn dogs. This is the first demonstration of a whole body gene transfer in a large animal model...
- Alexey V Zaitsev; Fiscal Year: 2015..IKATP in these phenomena will also be investigated in the whole heart (Aim 2) and in isolated myocytes (Aim 3) of dogs. Together these studies will define 1) the molecular basis of KNa channel activation, 2) the role of these channels ..
- Mechanisms regulating SR Ca2+ ATPase in the AtriaMuthu Periasamy; Fiscal Year: 2012..In addition, we found that SLN levels are significantly altered in diseased atria (heart failure and arrhythmia) of dogs and human, suggesting that an alteration in SLN /SERCA ratio could contribute to altered Ca2+ transport in failing ..
- NCRR RESEARCH TRAINING FOR TUFTS VETERINARY STUDENTSROBERT STAFFORD BRIDGES; Fiscal Year: 2013..Using animal models that include pigs, horses, sheep, goats, cats, dogs, rats and mice, program faculty will provide intensive laboratory training in the research areas of infectious ..
- Early Phase Pre-Clinical and Initial Clinical Research on EpicatechinFrancisco J Villarreal; Fiscal Year: 2013..Aim 2. Pursue pharmacokinetic (PK) studies in rodents and/or dogs using (+/-)-epicatechin...
- Laura L Dugan; Fiscal Year: 2014..Loss of these neurons is observed in rodents, dogs, and primates, and has been proposed to underlie cognitive deficits across cognitive domains...
- Shuping Zhang; Fiscal Year: 2015..b>Dogs and cats are not commonly thought of as a source for human infection, but Campylobacter carriage is well-recognized ..
- Anil J Thachil; Fiscal Year: 2016..The foods that we feed our dogs and cats may be a combination of commercially available raw meat diets, companion animal diets (soft/moist;dry/low ..
- JUSTIN RODNEY SAVAGE; Fiscal Year: 2015..resorption, (iii) test tolerability of topical formulations for delivery of GM-0111 into the sulcus in dose-ranging studie in beagle dogs, and (iv) conduct a pivotal study in beagle dogs to test the efficacy of the selected formulation.
- Alan D Cherrington; Fiscal Year: 2016..Studie will be carried out in normal and diet induced insulin resistant conscious dogs. Three weeks before study catheters will be inserted under general anesthesia into the femoral artery, the hepatic ..
- Shuping Zhang; Fiscal Year: 2016..We currently serve as an FDA site for detection of Salmonella in samples from dogs and cats...
- Ogi Okwumabua; Fiscal Year: 2016Abstract In 2007, cats and dogs that ate certain pet foods became sick and several of them died. Investigation revealed that the incident was due to melamine adulteration of animal food ingredients...
- Susan Sanchez; Fiscal Year: 2016..Furthermore, we were the first laboratory to diagnose melamine toxicosis in dogs due to contaminated components in canned pet food...
- Margret L Casal; Fiscal Year: 2016..repeat (LTR) expressing canine GUSB resulted in efficient transduction of liver cells in both mice and dogs with MPS VII...
- STEPHANIE ANN FRITZ; Fiscal Year: 2016..Commonly handled household objects and surfaces, and pet dogs and cats, will be cultured...
- Bifunctional Redox Catalyst &Organic Nitrate for Limb ReperfusionANDREW LURIE SALZMAN; Fiscal Year: 2013..IV dose range-finding and 2 week repeat-dose toxicology studies in rats and dogs, with associated toxicokinetic determinations.
- Adjunctive Use of Apyrase to Fibrinolytic TherapyRidong Chen; Fiscal Year: 2013..With the Phase I award, we demonstrated that in the r-tPA induced fibrinolysis model in dogs, treatment of APT102 completely prevented re-occlusion, maintained normal blood flow, and profoundly reduced ..
- Shulin Li; Fiscal Year: 2014..Our preliminary study in two dogs also suggests that IL12 gene therapy may prevent tumor redevelopment when co-administered with bleomycin via ..
- Colin R Parrish; Fiscal Year: 2016..and extend our work on two well characterized animal viruses that have successfully jumped species barriers to dogs in the recent past and which represent powerful and experimentally tractable models for human emerging viruses;the ..
- Evaluation of fecal salmonella in symptomatic and asymptomatic dogs and catsKRISTIN CLOTHIER; Fiscal Year: 2012..S., and the risks of 2 exposure to this agent through contact with dogs and cats are unknown...
- Salmonella Prevalence and Persistence in Companion AnimalsShuping Zhang; Fiscal Year: 2012..b>Dogs and cats are not commonly thought of as carriers of Salmonella, but Salmonella infection is well-recognized in ..
- Salmonella serotype distribution in pets presented to veterinary teaching and comSiddhartha Thakur; Fiscal Year: 2012Project Summary Companion animals, including dogs and cats, are known reservoirs of Salmonella spp. and potential sources of transmission for humans through direct or indirect contact...
- Evaluation of Salmonella in Symptomatic and Asymptomatic Pets: Study for the Vet-Shelley Rankin; Fiscal Year: 2012..There is a scarcity of information on the prevalence of Salmonella in dogs and much of the available research highlights one particular confounding factor: quite often the observed ..
- SARS-CoV Pathogenic Mechanisms in Senescent MiceRalph S Baric; Fiscal Year: 2012..SARS-CoV) is a zoonotic pathogen that likely emerged from bats, was amplified in civet cats and raccoon dogs and then transmitted to humans causing severe acute respiratory disease, pneumonia, and high mortality rates in the ..
- REMODELING RESEARCH ANIMAL ROOMSDONALD MAUL; Fiscal Year: 1990..animal facility and the quarantine facility at the Veterinary Teaching Hospital (VTH) currently house cats and/or dogs in projects from the departments of Radiology and Radiation Biology, and Clinical Sciences in the College of ..
- Brain Vascular Studies in Cardiac and Orthopedic SurgeryWilliam Brown; Fiscal Year: 2009..We will perform MRI on six groups of dogs which simulate surgical embolic events...
- Abnormality in Gene Expression of Key Mediators of Vitamin A Action in COPDSalil K Das; Fiscal Year: 2010..RA is known to be effective in promoting alveolization in papain-induced emphysema in dogs and elastase-induced emphysema in adult rats...
- Disruption of Autonomic Pathways in Left Atrium by Inhibition of G ProteinsAlan H Kadish; Fiscal Year: 2010..to study the effects of the peptide(s) on ion-channels that mediate autonomic effects, and in b) intact dogs, with localized injection into the PLA in order to inhibit vagally or adrenergically-mediated AF...
- MYOCARDIAL PERFUSION IN THE HYPERTROPHIED HEARTROBERT JAMES BACHE; Fiscal Year: 2010..Pacing-induced tachycardia will be used to produce CHF in dogs;animals will be chronically instrumented for measurement of left ventricular (LV) function and MVO2...
- Genes, Home Allergens and Asthma in Puerto Rican ChildrenJUAN CARLOS CELEDON; Fiscal Year: 2010..We will then examine whether parental report of exposure to each of two pets (dogs and cats) in early life is associated with reduced risks of asthma (in all subjects) and atopy (separately in cases ..
- Improving Safety and Access for Physical ActivityDawn K Wilson; Fiscal Year: 2010..minority adults would like to increase the safe places for PA (areas free from crime, containment of stray dogs, increased police patrol) and access to PA (sidewalks/trails and expand opportunities for PA) in their community...
- Inhibition of IkK to treat lethal Graft-vs.-Host DiseasePatrick Flood; Fiscal Year: 2009..Finally, studies are proposed to investigate the pharmacokinetics and pharmacodynamics of the compound in dogs after transplantation...
- Towards a Model of Fanconi AnemiaBEVERLY JO TOROK STORB; Fiscal Year: 2010..we will take several parallel paths to exploit this approach to derive the tools to generate genetically modified dogs, focusing on the future generation of a Fanconi anemia dog as a test of principle...
- Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical IllnessEva Szigethy; Fiscal Year: 2009..abstract_text> ..
- Novel Small Molecule Therapeutics to Treat ObesitySUSAN MEDGHALCHI; Fiscal Year: 2010..measurements to select a lead compound  perform a 5-day rat TK study,  undergo cardiac testing in conscious dogs, and  conclude a formal 28-day preclinical GLP rat toxicity study...
- NOC in processed meat as a likely cause of colon cancerSidney S Mirvish; Fiscal Year: 2012..We recently reported that hot dogs contain 5.5 nmol/g of total non-volatile apparent NOC (ANC)...
- NCRR RESEARCH TRAINING FOR TUFTS VETERINARY STUDENTSROBERT STAFFORD BRIDGES; Fiscal Year: 2011..Using animal models that include pigs, horses, sheep, goats, cats, dogs, rats and mice, program faculty will provide intensive laboratory training in the research areas of infectious ..
- Generation of Novel Recombinant Rabies Virus VaccinesBERNHARD F DIETZSCHOLD; Fiscal Year: 2010..we will confirm the safety and stability of this highly attenuated RV variant and test its efficacy in hamsters and dogs, which have been demonstrated to be reliable animal models for pre- and post-exposure evaluation of rabies vaccines...
- Estimating the Causal Effect of Interacting with Pet Dogs and CatsJEREMY NOWELL VILLETTE MILES; Fiscal Year: 2011..In 2003, CHIS surveyed 42,000 adults and asked about dogs and cats living in their households...
- Genetic components influencing the feline - human social bondLeslie A Lyons; Fiscal Year: 2011..been linked to genetic variation of the genes within these biological pathways in humans, primates, rodents, and dogs. The objective of this R03 request is to investigate the influence of genetic variation in a cat's role in AAI ..
- Xenoestrogen regulation of Leydig cellsBENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010..g., use of pigs to study obesity and diabetes and dogs for cardiopulmonary diseases...
- Radiation Dose-Dependent InterventionsGeorge Earl Georges; Fiscal Year: 2010..The complementary and integrated dosimetry methods will be studied in dogs exposed to varying doses of total body irradiation (TBI) and validated in patients undergoing radiation therapy...
- Antihypertensive Effects of Tetanic Baraoreceptor Input StimulationXiaorui Tang; Fiscal Year: 2011..the effects of uni- and bi-lateral CSN tetanus on basal BP in normotensive and obesity-induced hypertensive dogs. Thirteen (10 experimental + 3 control) dogs will be used;every dog will have bilateral CSN electrodes...
- Proteomic signatures of an early life asthma-protective exposureSerrine S Lau; Fiscal Year: 2010..g., indoor dogs) is associated with strong protection against asthma and asthma-related phenotypes (allergy, eczema) later in life...
- Novel Adeno-Associated Viral Therapy for X-linked Retinitis PigmentosaJames M Wilson; Fiscal Year: 2010..promoter and RPGR transgene will be put through biodistribution and safety/toxicology studies in mice and in dogs to complete the package of data needed for filing an IND...
- DIETARY & GENETIC CONTROL OF ROS DAMAGE TO THE LENSNorman S Wolf; Fiscal Year: 2010..This work has shown the mechanisms at work in the development of ARC, in mice and rats, and still underway, in dogs and humans...
- Intervention strategies of hemorrhagic colitis and HUSEdgar Boedeker; Fiscal Year: 2004..coli (EHEC) infection, in rabbits and dogs, to develop therapeutic regimens to prevent and treat EHEC disease...
- HEMOSTATIC DEFECTS AND THYROID HORMONE THERAPYWINIFRED DODDS; Fiscal Year: 1990..A unique colony of dogs with well- characterized inherited defects and a clinical population of dogs referred for bleeding problems will be ..
- DETERMINANTS OF REGIONAL LUNG EXPANSION AND PERFUSIONEric Hoffman; Fiscal Year: 1993..geometry in determinining regional distribution of lung air content and pulmonary blood flow in anesthetized Beagle dogs. Three major hypotheses will be tested: 1) The intrathoracic position of the heart is a major determinant of ..
- MYOCARDIAL PROTEIN KINASE C & B-ADRENOCEPTORS IN CHFChang Seng Liang; Fiscal Year: 1990..1) to compare the number and/or activity of cardiac sarcolemmal protein kinase C in heart failure and sham-operated dogs, 2) to characterize the protein kinase C-catalyzed phosphorylation of endogenous substrate proteins in the ..
- Development of a canine model of radiotherapy induced oral mucositisDorothy C Brown; Fiscal Year: 2010..Companion (pet) dogs spontaneously develop HNC and are routinely treated with RT...
- Aminopterin for the Treatment of Severe Recalcitrant Atopic DermatitisStuart Kahn; Fiscal Year: 2009..It is estimated that 10% of dogs suffer from AD...
- Vaccine induced resistance against E. granulosus in dogsWenbao Zhang; Fiscal Year: 2007..echinococcosis) is a cosmopolitan zoonosis caused by the tape-worm Echinococcus granulosus in the intestine of dogs. The disease is important not only in terms of public health, but also for economic development in poorer endemic ..
- A novel in vivo test system to evaluate therapeutic antibodies in dog models of sGENEVIEVE HANSEN; Fiscal Year: 2010..antibody drug candidates with sequences compatible with the dog immune system to allow repeated administration in dogs, and (2) their testing for efficacy and safety in a dog model of spontaneous cancer...
- CAROTID BAROREFLEX CONTROL IN NORMO- AND HYPERTENSIONMARTHA BRUNNER; Fiscal Year: 1992..The studies will be performed in hypertensive dogs with chronically isolated carotid sinus regions...
- Treatment for Canine Diabetic CataractsMilton Wyman; Fiscal Year: 2007..In dogs, DM is characterized by the rapid onset of bilateral sugar cataracts which often result in vision loss...
- Development of normal and dystrophic canine iPS linesCOLIN EDWARD BISHOP; Fiscal Year: 2010A large number of genetic diseases occur in dogs mainly due to founder effects and population bottlenecks resulting from centuries-old inbreeding practices...
- HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITISSTEVEN KINCAID; Fiscal Year: 1991..The left knees of 4 groups of 4 dogs will be immobilized by casts for 56 days. A fifth group of 4 dogs will serve as untreated controls...
- Improving Gastrointestinal Recovery after RadiationGeorge Georges; Fiscal Year: 2007..syndrome will be given after TBI, and in Aim 2, the drugs will be given before and after TBI to achieve survival of dogs with good GI tract recovery. Based on our prior work in this model, we will begin with a TBI dose of 10 Gy at 0...
- Xanthine oxidase inhibitor for congestive heart failureAlex Nivorozhkin; Fiscal Year: 2002..In heart failure dogs, but not controls, allopurinol decreases MVO2 and substantially increases mechanical efficiency...
- MAST CELL MATRIX METALLOPROTEINASES IN LUNG INJURYKenneth Fang; Fiscal Year: 2000..The preliminary data demonstrate that dog mastocytoma cells secrete and activate their own matrix metalloproteinases (MMPs), supporting the hypothesis that ..
- MODULATORS OF GASTRIC HISTAMINE RELEASE IN VIVOJohn Gerber; Fiscal Year: 1993The aim of this proposal is to examine the factors controlling the release of gastric histamine in vivo in the dog. The overall hypothesis is that gastric mucosal histamine is regulated by gastric secretagogues, and the release is ..
- SUBENDOCARDIAL O2 SUPPLY AND DEMAND IN AORTIC STENOSISPeter Scholz; Fiscal Year: 1992..All studies will be conducted on anesthetized open chest dogs 6 months after creation of aortic valve stenosis as puppies...
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