common platanna

Summary

Alias: platanna, African clawed frog, clawed frog, Xenopus laevis, Xenopus leavis, Bufo laevis, Xenopus laevis (Daudin, 1802)

Top Publications

  1. ncbi Crystal structure of the nucleosome core particle at 2.8 A resolution
    K Luger
    Institut fur Molekularbiologie und Biophysik, Zurich, Switzerland
    Nature 389:251-60. 1997
  2. ncbi Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos
    Qinghua Tao
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Cell 120:857-71. 2005
  3. ncbi Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis
    A P McMahon
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Cell 58:1075-84. 1989
  4. pmc Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts
    Satoru Mochida
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts, UK
    EMBO J 28:2777-85. 2009
  5. ncbi Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein
    J E Lee
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Science 268:836-44. 1995
  6. pmc Identification of Xenopus SMC protein complexes required for sister chromatid cohesion
    A Losada
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 USA
    Genes Dev 12:1986-97. 1998
  7. ncbi The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    L B Zimmerman
    Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720, USA
    Cell 86:599-606. 1996
  8. pmc The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos
    Jennifer L Stubbs
    The Salk Institute for Biological Studies, San Diego, CA 92186, USA
    Nat Genet 40:1454-60. 2008
  9. ncbi Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome
    Mahesh N Sangrithi
    Cancer Research UK Department of Oncology, University of Cambridge, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Cell 121:887-98. 2005
  10. pmc Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movements
    Gun Hwa Kim
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea
    EMBO J 26:2513-26. 2007

Research Grants

  1. MELATONIN'S ROLE IN TECTAL PHYSIOLOGY AND PLASTICITY
    Susan Udin; Fiscal Year: 2003
  2. Ming Zhou; Fiscal Year: 2014
  3. Hassane Amlal; Fiscal Year: 2014
  4. Mechanism of action of novel GluN2C NMDA receptor potentiators
    Alpa Khatri; Fiscal Year: 2013
  5. Modulation of the Epithelial Sodium Channel by Proteases and Peptide Inhibitors
    CHRISTOPHER JOHN PASSERO; Fiscal Year: 2010
  6. Novel Analgesics from Australian Funnel-Web Spider Venom
    MICHAEL NATHAN NITABACH; Fiscal Year: 2010
  7. Cholinergic receptors on the nematode pharynx: an unexploited drug target
    Alan P Robertson; Fiscal Year: 2012
  8. Paul A Welling; Fiscal Year: 2016
  9. Molecular Physiology of y-Aminobutyric Acid Transporters
    Sepehr Eskandari; Fiscal Year: 2012
  10. Studies with Nicotinic Null Mutant Mice
    Michael J Marks; Fiscal Year: 2013

Patents

  1. POLYPEPTIDES, NUCLEIC ACIDS AND USES THEREOF
  2. O-CADHERIN AS A BIOMARKER FOR CIRCULATING TUMOR CELLS
  3. PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME
  4. RSPONDINS AS MODULATORS OF ANGIOGENESIS AND VASCULOGENESIS
  5. ALBUMIN INSULIN FUSION PROTEIN
  6. Nucleic acids sequence of a cell death-inducible vector, and the transgenic silkmoth strains carrying the DNA fragment inducing tissue-specific cell death
  7. Nucleic acids sequence of a cell death-inducible vector, and the transgenic silkmoth strains carrying the DNA fragment inducing tissue-specific cell death
  8. COMPOSITIONS AND METHODS MODULATING MG29 FOR THE TREATMENT OF DIABETES
  9. METHOD FOR ANALYZING MUCIN 1 USING PROBE CAPABLE OF BINDING TO 3'-SULFONATED CORE 1 CARBOHYDRATE CHAIN, AND METHOD FOR DETECTING OR MONITORING BREAST CANCER
  10. ANTIBODY PRODUCTION METHOD

Detail Information

Publications453 found, 100 shown here

  1. ncbi Crystal structure of the nucleosome core particle at 2.8 A resolution
    K Luger
    Institut fur Molekularbiologie und Biophysik, Zurich, Switzerland
    Nature 389:251-60. 1997
    ..The lack of uniformity between multiple histone/DNA-binding sites causes the DNA to deviate from ideal superhelix geometry...
  2. ncbi Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos
    Qinghua Tao
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Cell 120:857-71. 2005
    ..Second, we show that activation requires the glycosyl transferase X.EXT1. Third, we find that the EGF-CFC protein, FRL1, is also essential and interacts with Wnt11 to activate canonical Wnt signaling...
  3. ncbi Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis
    A P McMahon
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Cell 58:1075-84. 1989
    ..This result suggests that ectopic int-1 expression leads to dual axis formation and points to a role for int-1 in patterning processes in vertebrate development...
  4. pmc Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts
    Satoru Mochida
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts, UK
    EMBO J 28:2777-85. 2009
    ..Increasing the concentration of PP2A-B55 delta in extracts by adding recombinant enzyme inhibited the entry into mitosis. This form of PP2A seems to be a key regulator of entry into and exit from mitosis...
  5. ncbi Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein
    J E Lee
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Science 268:836-44. 1995
    ..The data suggest that neuroD may participate in the terminal differentiation step during vertebrate neuronal development...
  6. pmc Identification of Xenopus SMC protein complexes required for sister chromatid cohesion
    A Losada
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 USA
    Genes Dev 12:1986-97. 1998
    ..These results suggest that proper assembly of mitotic chromosomes is regulated by two distinct classes of SMC protein complexes, cohesins and condensins...
  7. ncbi The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    L B Zimmerman
    Department of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720, USA
    Cell 86:599-606. 1996
    ..These data suggest that noggin secreted by the organizer patterns the embryo by interrupting BMP signaling...
  8. pmc The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos
    Jennifer L Stubbs
    The Salk Institute for Biological Studies, San Diego, CA 92186, USA
    Nat Genet 40:1454-60. 2008
    ..These results indicate that Foxj1 is a critical determinant in the specification of cilia used in left-right patterning...
  9. ncbi Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome
    Mahesh N Sangrithi
    Cancer Research UK Department of Oncology, University of Cambridge, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Cell 121:887-98. 2005
    ..Here, we implicate in this process the Xenopus laevis homolog (xRTS) of the RECQL4 helicase mutated in Rothmund-Thomson syndrome...
  10. pmc Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movements
    Gun Hwa Kim
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea
    EMBO J 26:2513-26. 2007
    ..We provide evidence that the endocytic activity of xbetaarr2 is essential for control of CE movements. Taken together, our results suggest that betaarr2 has a pivotal role in the regulation of Xenopus CE movements...
  11. ncbi Repression of nodal expression by maternal B1-type SOXs regulates germ layer formation in Xenopus and zebrafish
    Chi Zhang
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, 80309 0347, USA
    Dev Biol 273:23-37. 2004
    ..A mechanistically conserved system appears to act in a similar manner in the zebrafish...
  12. ncbi CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment
    K W Wood
    Laboratory of Cell Biology, Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla 92093 0660, USA
    Cell 91:357-66. 1997
    ..We further demonstrate that CENP-E powers movement toward microtubule plus ends in vitro. These findings support a model in which CENP-E functions in congression to tether kinetochores to dynamic microtubule plus ends...
  13. pmc The structural determinants of checkpoint activation
    Christina A MacDougall
    Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305, USA
    Genes Dev 21:898-903. 2007
    ..These observations define the minimal DNA requirements for checkpoint activation and suggest that primed ssDNA represents a common checkpoint activating-structure formed following many types of damage...
  14. ncbi XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
    M Molenaar
    Department of Immunology University Hospital, Utrecht The Netherlands
    Cell 86:391-9. 1996
    ..We propose that signaling by beta-catenin involves complex formation with XTcf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes...
  15. ncbi Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
    T Bouwmeester
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, 90095 1737, USA
    Nature 382:595-601. 1996
    ..The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo...
  16. ncbi The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis
    D A Wettstein
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    Development 124:693-702. 1997
    ..These results suggest that activation of X-Su(H) is a key step in the Notch signaling pathway during primary neurogenesis in Xenopus embryos...
  17. ncbi Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction
    J C Smith
    Laboratory of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London
    Cell 67:79-87. 1991
    ..Expression of Xbra in response to these factors is rapid, and will occur in dispersed cells and in the presence of a protein synthesis inhibitor, indicating that this is an "immediate-early" response to mesoderm induction...
  18. pmc Complement fragment C3a controls mutual cell attraction during collective cell migration
    Carlos Carmona-Fontaine
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Dev Cell 21:1026-37. 2011
    ..We propose that coattraction and contact inhibition act in concert to allow cell collectives to self-organize and respond efficiently to external signals, such as chemoattractants and repellents...
  19. ncbi Synergism between Pax-8 and lim-1 in embryonic kidney development
    T J Carroll
    Cell and Developmental Biology, University of Texas, Austin, Texas, 78712, USA
    Dev Biol 214:46-59. 1999
    ..Together these data indicate that the interaction between XPax-8 and Xlim-1 is a key early step in the establishment of the pronephric primordium...
  20. pmc The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication
    Kumiko Matsuno
    Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    Mol Cell Biol 26:4843-52. 2006
    ..Our data suggest that RecQ4 performs an essential role in the assembly of replication machinery through interaction with Cut5 in vertebrates...
  21. pmc Dissection of CENP-C-directed centromere and kinetochore assembly
    Kirstin J Milks
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 20:4246-55. 2009
    ..We find that the amino terminus of CENP-C promotes kinetochore assembly by ensuring proper targeting of the Mis12/MIND complex and CENP-K...
  22. pmc Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells
    S Jäkel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Germany
    EMBO J 17:4491-502. 1998
    ..The presence of distinct binding sites for rpL23a and the M9 import signal in transportin, and for rpL23a and importin alpha in importin beta might explain how a single receptor can recognize very different import signals...
  23. ncbi Maskin is a CPEB-associated factor that transiently interacts with elF-4E
    B Stebbins-Boaz
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Mol Cell 4:1017-27. 1999
    ..The dissolution of this complex may result in the binding of elF-4E to elF-4G and the translational activation of CPE-containing mRNAs...
  24. pmc beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation
    C Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:6273-8. 1999
    ..Therefore, beta-Trcp plays a central role in recruiting phosphorylated beta-catenin for degradation and in dorsoventral patterning of the Xenopus embryo...
  25. doi XMAP215 activity sets spindle length by controlling the total mass of spindle microtubules
    Simone B Reber
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauer Str 108, 01307 Dresden, Germany
    Nat Cell Biol 15:1116-22. 2013
    ..engineering the enzymatic activity of XMAP215, a processive microtubule polymerase, we show that Xenopus laevis spindle length increases linearly with microtubule growth velocity, whereas other parameters of spindle ..
  26. pmc Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction
    K Itoh
    Department of Microbiology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 20:2228-38. 2000
    ..Finally, our data point to a possible mechanism for signal transduction, in which Xdsh prevents beta-catenin degradation by displacing GSK3 from its complex with XARP...
  27. pmc Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes
    A Losada
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Cell Biol 150:405-16. 2000
    ..protein complex, termed cohesin, plays an essential role in sister chromatid cohesion in yeast and in Xenopus laevis cell-free extracts. We report here that two distinct cohesin complexes exist in Xenopus egg extracts...
  28. pmc XPak3 promotes cell cycle withdrawal during primary neurogenesis in Xenopus laevis
    Jacob Souopgui
    Institut fur Biochemie und Molekulare Zellbiologie, Georg August Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    EMBO J 21:6429-39. 2002
    ..We conclude that XPak3 is a novel member of the proneural pathway, functioning downstream of neurogenin to withdraw neuronally programmed cells from the mitotic cell cycle, thus allowing for their differentiation...
  29. ncbi Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts
    Ana Losada
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    J Cell Sci 118:2133-41. 2005
    ..This idea would explain why cells lacking Pds5 function display rather complex and diverse phenotypes in different organisms...
  30. ncbi Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts
    Jiangtao Yu
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Mol Cell 22:83-91. 2006
    ..These results demonstrate that Greatwall participates in an autoregulatory loop that generates and maintains sufficiently high MPF activity levels to support mitosis...
  31. doi The Xenopus MEF2 gene family: evidence of a role for XMEF2C in larval tendon development
    Bruno Della Gaspera
    UMR 7060 CNRS, Equipe Biologie du Développement et de la Différenciation Neuromusculaire, Centre Universitaire des Saints Peres, 45, rue des Saints Pères, Universite Paris Descartes, F 75270 Paris Cedex 06, France
    Dev Biol 328:392-402. 2009
    ....
  32. ncbi Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A
    Frank Eckerdt
    Howard Hughes Medical Institute and Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Cycle 8:2413-9. 2009
    ..Taken together, our data indicate that Plx1 promotes activation of Aurora A, most likely through TPX2. In light of the current literature, we propose a model in which Plx1 and Aurora A activate each other in a positive feedback loop...
  33. doi Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle
    Thierry Lorca
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    J Cell Sci 123:2281-91. 2010
    ....
  34. pmc Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
    Yoshitami Hashimoto
    London Research Institute, South Mimms, Hertfordshire, UK
    Nat Struct Mol Biol 17:1305-11. 2010
    ..Here, using EM to visualize replication intermediates assembled in Xenopus laevis egg extract, we show that Rad51 is required to prevent the accumulation of single-stranded DNA (ssDNA) gaps at ..
  35. pmc CK1 activates minus-end-directed transport of membrane organelles along microtubules
    Kazuho Ikeda
    Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Biol Cell 22:1321-9. 2011
    ....
  36. pmc Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis
    Kyeongmi Kim
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Dev Dyn 241:1385-95. 2012
    ..As Rab11-dependent vesicle trafficking has been implicated in ciliary membrane assembly and in apical domain formation in epithelial cells, we assessed the involvement of Rab11 in MCC development...
  37. pmc The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition
    Elias H Barriga
    Department of Cell and Developmental Biology, University College London, London, England, UK
    J Cell Biol 201:759-76. 2013
    ..Inhibition of Hif-1α by antisense morpholinos in Xenopus laevis or zebrafish embryos led to complete inhibition of neural crest migration...
  38. pmc Deuterosome-mediated centriole biogenesis
    Deborah A Klos Dehring
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Dev Cell 27:103-12. 2013
    ..However, in CCDC78 morphants, Cep152 fails to localize to the deuterosome and centriole biogenesis is impaired, indicating that CCDC78-mediated recruitment of Cep152 is required for deuterosome-mediated centriole biogenesis. ..
  39. pmc Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos
    Jolanta Kisielewska
    University of Newcastle, The Institute for Cell and Molecular Biosciences, Framlington Place, NE2 4HH, Newcastle upon Tyne, UK
    Development 139:63-74. 2012
    ....
  40. pmc Sequential expression of multiple POU proteins during amphibian early development
    C S Hinkley
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Mol Cell Biol 12:638-49. 1992
    ..By analogy with other members of the POU-domain gene family, the products of these genes may play critical roles in the determination of cell fate and the regulation of cell proliferation...
  41. ncbi Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    A Glinka
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 391:357-62. 1998
    ..Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors...
  42. ncbi A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase
    P A Wade
    Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Biol 8:843-6. 1998
    ..We purified a multi-subunit complex from Xenopus laevis eggs which contains six putative subunits including the known deacetylase subunits Rpd3 and RbAp48/p46 [8] as ..
  43. ncbi Two novel nodal-related genes initiate early inductive events in Xenopus Nieuwkoop center
    S Takahashi
    Department of Life Sciences Biology, The University of Tokyo, Tokyo 153 8902, Japan
    Development 127:5319-29. 2000
    ..The expression of Xnr5 and Xnr6 is regulated by maternal VegT and (beta)-catenin, but does not require TGF-(beta) signaling. Therefore, expression of Xnr5 and Xnr6 is controlled by different mechanisms from other Xnr family genes...
  44. ncbi Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest
    Manuel J Aybar
    Millennium Nucleus in Developmental Biology, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Development 130:483-94. 2003
    ....
  45. ncbi The Notch-effector HRT1 gene plays a role in glomerular development and patterning of the Xenopus pronephros anlagen
    Vincent Taelman
    Laboratoire d Embryologie Moleculaire, Universite Libre de Bruxelles, Institut de Biologie et de Médecine Moléculaires IBMM, Gosselies, Belgium
    Development 133:2961-71. 2006
    ..Together, our results provide evidence that XHRT1 plays an important role in glomerular development and early proximodistal patterning that is distinct from those of the other pronephric bHLH repressors...
  46. ncbi Frizzled7 mediates canonical Wnt signaling in neural crest induction
    Muhammad Abu-Elmagd
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Dev Biol 298:285-98. 2006
    ..We therefore demonstrate that Xfz7 is regulated by BMP antagonism and is required for neural crest induction by Wnt in the developing vertebrate embryo...
  47. ncbi Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin
    Kristijan Ramadan
    Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland
    Nature 450:1258-62. 2007
    ..These data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation...
  48. pmc Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation
    Ying Cao
    Institute of Biochemistry, University of Ulm, Ulm, Germany
    J Biol Chem 283:34168-77. 2008
    ..Our results provide a novel view in that Oct25 controls the nodal/activin pathway and thus maintains the undifferentiated state of embryonic cells in preventing them from premature differentiation...
  49. pmc E3 ligase Nedd4 promotes axon branching by downregulating PTEN
    Jovana Drinjakovic
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Neuron 65:341-57. 2010
    ..Together our data suggest that Nedd4-regulated PTEN is a key regulator of terminal arborization in vivo...
  50. pmc Xvent-1 mediates BMP-4-induced suppression of the dorsal-lip-specific early response gene XFD-1' in Xenopus embryos
    H Friedle
    Abteilung Biochemie, Universitat Ulm, Albert Einstein Allee 11, D 89081 Ulm, Germany
    EMBO J 17:2298-307. 1998
    ..Thus, biological and molecular data suggest that Xvent-1 acts as direct repressor for XFD-1' transcription and mediates BMP-4-induced inhibition...
  51. pmc A conserved family of elav-like genes in vertebrates
    P J Good
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 92:4557-61. 1995
    ..I have identified genes related to elav and HuD in Xenopus laevis, zebrafish, and mouse that define a family of four closely related vertebrate elav-like genes (elrA, elrB, ..
  52. ncbi Replication focus-forming activity 1 and the Werner syndrome gene product
    H Yan
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Nat Genet 19:375-8. 1998
    ..Using Xenopus laevis egg extracts, we have identified and purified a 170-kD protein, focus-forming activity 1 (FFA-1), which is ..
  53. ncbi Lens regeneration in Xenopus is not a mere repeat of lens development, with respect to crystallin gene expression
    N Mizuno
    Department of Developmental Biology, National Institute for Basic Biology, Okazaki, Japan
    Differentiation 64:143-9. 1999
    The spatio-temporal expression of three crystallin genes (alpha A, beta B1 and gamma) in lenses of Xenopus laevis was studied by in situ hybridization to compare the process of lens formation in embryonic development with that of lens ..
  54. pmc ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing
    Peter J Gillespie
    Division of Gene Regulation and Expression, College of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Curr Biol 17:1657-62. 2007
    ..Because nuclear assembly is required to shut down licensing prior to entry into S phase, our results suggest a mechanism by which these two early cell-cycle events are coordinated with one another...
  55. pmc Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM
    Karen E Wawrousek
    Division of Biology, California Institute of Technology, Pasadena, CA, USA
    Cell Cycle 9:1156-66. 2010
    We have used the Xenopus laevis egg extract system to study the roles of vertebrate Dna2 in DNA replication and double-strand-break (DSB) repair.  We first establish that Xenopus Dna2 is a helicase, as well as a nuclease...
  56. pmc Asymmetric endocytosis and remodeling of beta1-integrin adhesions during growth cone chemorepulsion by MAG
    Jacob H Hines
    Mayo Graduate School, Mayo Clinic, Rochester, Minnesota, USA
    Nat Neurosci 13:829-37. 2010
    ..Such dynamic redistribution allows the growth cone to rapidly adjust adhesiveness across its axis, an essential feature for initiating chemotactic turning...
  57. ncbi Dynamic patterns of gene expression in the developing pronephros of Xenopus laevis
    T J Carroll
    Department of Zoology, University of Texas, Austin 78712, USA
    Dev Genet 24:199-207. 1999
    ..We describe restrictions of these gene expression patterns within the pronephros which indicate a model for the partitioning of the common pronephric anlage into its three component parts--the tubules, the glomus, and the duct...
  58. ncbi A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro
    T Hirano
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Cell 79:449-58. 1994
    ..These motifs are highly conserved in a protein family, members of which have been identified recently in both prokaryotes and eukaryotes...
  59. ncbi Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin
    A M Zorn
    Wellcome Trust Cancer Research Campaign Institute of Cancer and Developmental Biology, Cambridge
    Mol Cell 4:487-98. 1999
    ..Two additional Sox proteins, XSox17 alpha and XSox3, likewise bind to beta-catenin and inhibit its TCF-mediated signaling activity. These results reveal an unexpected mechanism by which Sox proteins can modulate Wnt signaling pathways...
  60. ncbi Frodo interacts with Dishevelled to transduce Wnt signals
    Joachim Gloy
    Department of Microbiology and Molecular Genetics, Harvard Medical School, and Molecular Medicine Unit, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Nat Cell Biol 4:351-7. 2002
    ..a novel conserved Dsh-binding protein, synergized with Xenopus Dsh (XDsh) in secondary axis induction in Xenopus laevis embryos...
  61. ncbi Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation
    Daron C Barnard
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 119:641-51. 2004
    ..The identification of these factors has broad implications for biological process that employ polyadenylation-regulated translation, such as gametogenesis, cell cycle progression, and synaptic plasticity...
  62. ncbi Essential role of non-canonical Wnt signalling in neural crest migration
    Jaime De Calisto
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 132:2587-97. 2005
    ....
  63. ncbi TopBP1 activates the ATR-ATRIP complex
    Akiko Kumagai
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 124:943-55. 2006
    ..These studies establish that activation of ATR by TopBP1 is a crucial step in the initiation of ATR-dependent signaling processes...
  64. ncbi Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis
    Roland E Kälin
    Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
    Dev Biol 305:599-614. 2007
    ..Thus, our results define apelin and APJ as genes of potential diagnostic value and promising targets for the development of a new generation of anti-tumor angiogenic drugs...
  65. pmc RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks
    Yoshitami Hashimoto
    Genome Stability Unit, Clare Hall Laboratories, London Research Institute, South Mimms, Hertfordshire, UK
    Nat Struct Mol Biol 19:17-24. 2011
    ..These results show that, in higher eukaryotes, replisomes are partially dismantled after fork collapse and fully re-established by a recombination-mediated process...
  66. pmc Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts
    Craig A Leach
    The Biological Laboratories, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Cell Biol 171:947-54. 2005
    ..b>Xenopus laevis PCNA is modified on lysine 164 by sumoylation, monoubiquitylation, and diubiquitylation...
  67. ncbi Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization
    A Hemmati-Brivanlou
    Department of Molecular and Cellular Biology, University of California, Berkeley 94720
    Development 110:325-30. 1990
    ..The sequence of an XA-1 cDNA predicts a protein rich in proline and histidine...
  68. pmc A novel p34(cdc2)-binding and activating protein that is necessary and sufficient to trigger G(2)/M progression in Xenopus oocytes
    I Ferby
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 13:2177-89. 1999
    ..Our results identify a novel p34(cdc2) binding and activating protein that regulates the G(2)/M transition during oocyte maturation...
  69. ncbi Neural crest induction by paraxial mesoderm in Xenopus embryos requires FGF signals
    Anne Hélène Monsoro-Burq
    Department of Molecular and Cellular Biology, University of California at Berkeley, CA 94720, USA
    Development 130:3111-24. 2003
    ..These results suggest that different signal transduction mechanisms may be used in neural crest induction, and anteroposterior neural patterning...
  70. pmc Metamorphic T3-response genes have specific co-regulator requirements
    Emmanuelle Havis
    Departement Regulations, Developpement et Diversite Moleculaire, UMR 5166 CNRS, 7 rue Cuvier, 75231 Paris Cedex 05, France
    EMBO Rep 4:883-8. 2003
    ..Most importantly, we show that individual T3-response genes have distinct co-regulator requirements, the T3-dependent co-repressor-to-coactivator switch being gene-specific for both co-regulator categories...
  71. ncbi Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation
    Stephan A Wacker
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT, Utrecht, Netherlands
    Dev Biol 268:207-19. 2004
    ..We postulate that the temporal information from the non-organiser mesoderm is linked to mesodermal Hox expression...
  72. pmc Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus
    Anatoliy Li
    Wellcome Trust Biocentre, University of Dundee, Dundee, UK
    EMBO J 24:395-404. 2005
    ..The results also explain the original experiments that led to the proposal of a replication licensing factor...
  73. ncbi G-protein-coupled signals control cortical actin assembly by controlling cadherin expression in the early Xenopus embryo
    Qinghua Tao
    Children s Hospital Research Foundation, Division of Developmental Biology, and Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, OH 45219, USA
    Development 134:2651-61. 2007
    ..This identifies a novel mechanism for control of cortical actin assembly during development that might be shared by many multicellular arrays...
  74. pmc Expression cloning of TMEM16A as a calcium-activated chloride channel subunit
    Björn Christian Schroeder
    Department of Physiology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Cell 134:1019-29. 2008
    ..The identification of this new family of ion channels may help the development of CaCC modulators for treating diseases including hypertension and cystic fibrosis...
  75. doi Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation
    Sang wook Cha
    Division of Developmental Biology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Development 135:3719-29. 2008
    ..We determine that Wnt5a and Wnt11 form a previously unrecognized complex. This work suggests a new aspect of Wnt signaling: two Wnts acting in a complex together to regulate embryonic patterning...
  76. pmc Identification of a novel dynein binding domain in nudel essential for spindle pole organization in Xenopus egg extract
    Shusheng Wang
    Department of Embryology, Carnegie Institution for Science and Howard Hughes Medical Institute, Baltimore, Maryland 21218, USA
    J Biol Chem 286:587-93. 2011
    ..Together, our findings open up new avenues to further decipher the mechanism of dynein regulation by Nudel and Lis1...
  77. ncbi Gamma-tubulin is a highly conserved component of the centrosome
    T Stearns
    Department of Biochemistry and Biophysics, University of California Medical School, San Francisco 94143
    Cell 65:825-36. 1991
    ..gamma-Tubulin remains associated with the centrosome when microtubules are depolymerized, suggesting that it is an integral component that might play a role in microtubule organization...
  78. ncbi Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
    M C Sanguinetti
    Department of Medicine, Cardiology Division, University of Utah, Salt Lake City 84112, USA
    Nature 384:80-3. 1996
    ..Coexpression of K(V)LQT1 with minK induced a current that was almost identical to cardiac I(Ks). Therefore, K(V)LQT1 is the subunit that coassembles with minK to form I(Ks) channels and I(Ks) dysfunction is a cause of cardiac arrhythmia...
  79. ncbi Requirement of FoxD3-class signaling for neural crest determination in Xenopus
    N Sasai
    Department of Medical Embryology and Neurobiology, and Department of Molecular and Cellular Biology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo, Kyoto 606 8507, Japan
    Development 128:2525-36. 2001
    ..These data demonstrate that FoxD3 (or its closely related factor) is an essential upstream regulator of neural crest determination...
  80. pmc The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication
    Ruth A Van Hatten
    Department of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    J Cell Biol 159:541-7. 2002
    ....
  81. pmc Cell cycle regulation of a Xenopus Wee1-like kinase
    P R Mueller
    Division of Biology 216 76, Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Mol Biol Cell 6:119-34. 1995
    ..These studies indicate that the down-regulation of Wee1-like kinase activity at mitosis is a multistep process that occurs after other biochemical reactions have signaled the successful completion of S phase...
  82. ncbi Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein
    T Hirano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 89:511-21. 1997
    ..Our results suggest that the condensin complexes represent the most abundant structural components of mitotic chromosomes and play a central role in driving chromosome condensation...
  83. pmc Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
    T Wittmann
    European Molecular Biology Laboratory, Cell Biology and Cell Biophysics Programs, D 69117 Heidelberg, Germany
    J Cell Biol 143:673-85. 1998
    ..We propose two molecular mechanisms that could account for the localization of Xklp2 to microtubule minus ends...
  84. ncbi Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts
    R Tournebize
    Cell Biology Program, EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 2:13-9. 2000
    ..These results indicate that microtubule dynamics in Xenopus egg extracts are regulated by a balance between a stabilizing factor, XMAP215, and a destabilizing factor, XKCM1...
  85. pmc Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements
    Gun Hwa Kim
    Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Hyoja Dong, Pohang, Kyungbuk 790 784, Republic of Korea
    J Cell Biol 182:1073-82. 2008
    ..Here, we report that Ryk regulates Xenopus laevis convergent extension (CE) movements via the beta-arrestin 2 (betaarr2)-dependent endocytic process triggered ..
  86. pmc CtIP links DNA double-strand break sensing to resection
    Zhongsheng You
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell 36:954-69. 2009
    ..Thus, CtIP facilitates the transition from DSB sensing to processing: it does so by binding to the DNA at DSBs after DSB sensing and ATM activation and then promoting DNA resection, leading to checkpoint activation and HR...
  87. doi Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis
    Satoru Mochida
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
    Science 330:1670-3. 2010
    ..This converts Ensa into a potent and specific inhibitor of PP2A-B55δ. This pathway represents a previously unknown element in the control of mitosis...
  88. pmc Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP
    Jawdat Al-Bassam
    Department of Molecular Cellular Biology, University of California, Davis, CA, USA
    Trends Cell Biol 21:604-14. 2011
    ..These are structurally related proteins that use conserved TOG domains to recruit tubulin dimers to MTs. We discuss models for how these proteins might use these individual tubulin dimers to regulate dynamic behavior of MT plus ends...
  89. doi MCM9 binds Cdt1 and is required for the assembly of prereplication complexes
    Malik Lutzmann
    Institute of Human Genetics, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France
    Mol Cell 31:190-200. 2008
    ..Thus, Cdt1, with its two opposing regulatory binding factors MCM9 and geminin, appears to be a major platform on the pre-RC to integrate cell-cycle signals...
  90. doi A role for the Fizzy/Cdc20 family of proteins in activation of the APC/C distinct from substrate recruitment
    Yuu Kimata
    Cell Cycle Control Laboratory, Marie Curie Research Institute, The Chart, Oxted, RH8 0TL Surrey, UK
    Mol Cell 32:576-83. 2008
    ..Our results reveal a role for the N-terminal domain of the Fizzy/Cdc20 family of activators in triggering substrate ubiquitylation by the APC/C...
  91. ncbi Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene
    G von Dassow
    Department of Biochemistry, University of Washington, Seattle 98195
    Genes Dev 7:355-66. 1993
    ..Our results provide experimental evidence supporting the proposed division of Spemann's organizer into independently regulated organizing centers...
  92. pmc Melanopsin: An opsin in melanophores, brain, and eye
    I Provencio
    Department of Anatomy and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 95:340-5. 1998
    We have identified an opsin, melanopsin, in photosensitive dermal melanophores of Xenopus laevis. Its deduced amino acid sequence shares greatest homology with cephalopod opsins...
  93. ncbi The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly
    C Roghi
    Departement de Biologie et Genetique du Developpement, Universite de Rennes I, Rennes, France
    J Cell Sci 111:557-72. 1998
    By differential screening of a Xenopus laevis egg cDNA library, we have isolated a 2,111 bp cDNA which corresponds to a maternal mRNA specifically deadenylated after fertilisation...
  94. ncbi XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development
    M Brannon
    Department of Biochemistry, Howard Hughes Medical Institute, Center for Developmental Biology, University of Washington School of Medicine, Seattle, Washington 98195 7350, USA
    Development 126:3159-70. 1999
    ..Our data support a role for XCtBP as a co-repressor throughout Xenopus development and indicate that XCtBP/G4A will be a useful tool in determining how XCtBP functions in various developmental processes...
  95. pmc Endodermal Nodal-related signals and mesoderm induction in Xenopus
    E Agius
    Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Development 127:1173-83. 2000
    ..The data support a modified model for mesoderm induction in Xenopus, in which mesoderm induction is mediated by a gradient of multiple Nodal-related signals released by endoderm at the blastula stage...
  96. pmc XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway
    Rebecca Hui Kwan Lee
    Department of Developmental Biology, National Institute for Basic Biology, Okazaki, Aichi, Japan
    EMBO J 26:3592-606. 2007
    ..We propose a novel signaling cascade consisting of XRab40/XCullin5, Rap2 and XMINK, which plays a crucial role in the regulation of the noncanonical Wnt pathway...
  97. pmc Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1
    V Gawantka
    Division of Molecular Embryology, German Cancer Research Center, Heidelberg, Germany
    EMBO J 14:6268-79. 1995
    ..Third, microinjection of Xvent-1 mRNA ventralizes dorsal mesoderm. The results suggest that Xvent-1 functions in a ventral signaling pathway that maintains the ventral mesodermal state and antagonizes the Spemann organizer...
  98. ncbi CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes
    Nicola Minshall
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    J Biol Chem 282:37389-401. 2007
    ..Altogether, our data suggest that CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T and eIF4E1b...
  99. ncbi The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
    Joon Lee
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 282:28036-44. 2007
    ..These findings suggest that interaction of the 9-1-1 complex with the BRCT I-II region of TopBP1 is necessary for binding of ATR-ATRIP to the ATR-activating domain of TopBP1 and the ensuing activation of ATR...
  100. pmc Xenopus cytoplasmic linker-associated protein 1 (XCLASP1) promotes axon elongation and advance of pioneer microtubules
    Astrid Marx
    Exzellenzcluster CellNetworks, University of Heidelberg, 69120 Heidelberg, Germany
    Mol Biol Cell 24:1544-58. 2013
    ..Lamellipodial architecture depended on XCLASP1 and its capacity to associate with MTs, highlighting the importance of XCLASP1 in actin-microtubule interactions...
  101. ncbi A developmentally regulated, nervous system-specific gene in Xenopus encodes a putative RNA-binding protein
    K Richter
    Institute of Molecular Biology, Austrian Academy of Science, Salzburg
    New Biol 2:556-65. 1990
    A gene from Xenopus laevis that is expressed specifically in the nervous system beginning at the stage of neural plate formation has been isolated and several cDNAs have been sequenced...

Research Grants77

  1. MELATONIN'S ROLE IN TECTAL PHYSIOLOGY AND PLASTICITY
    Susan Udin; Fiscal Year: 2003
    ..The tectum of Xenopus laevis frogs is an appropriate system in which to study melatonin's effects, since the tectum is richly endowed with ..
  2. Ming Zhou; Fiscal Year: 2014
    ..We have successfully expressed dvUT in Xenopus laevis oocytes, and found that it mediates urea flux through oocyte membrane...
  3. Hassane Amlal; Fiscal Year: 2014
    ..which will examine the expression and transport activity of NaPi-IIa using proximal tubule suspensions, Xenopus Laevis oocytes and MDCK cells...
  4. Mechanism of action of novel GluN2C NMDA receptor potentiators
    Alpa Khatri; Fiscal Year: 2013
    ..function and loss of function chimeras will be constructed between the GluN2A and Glun2C subunits expressed in Xenopus laevis oocytes...
  5. Modulation of the Epithelial Sodium Channel by Proteases and Peptide Inhibitors
    CHRISTOPHER JOHN PASSERO; Fiscal Year: 2010
    ..The Xenopus laevis oocyte expression system will be used for these studies...
  6. Novel Analgesics from Australian Funnel-Web Spider Venom
    MICHAEL NATHAN NITABACH; Fiscal Year: 2010
    ..terminals of nociceptors by screening atracotoxins against cloned nociceptor ion channels expressed in Xenopus laevis oocytes...
  7. Cholinergic receptors on the nematode pharynx: an unexploited drug target
    Alan P Robertson; Fiscal Year: 2012
    ..3. Characterize the pharyngeal cholinergic receptors in Xenopus laevis oocytes using voltage- &patch-clamp techniques...
  8. Paul A Welling; Fiscal Year: 2016
    ..The first two aims will involve functional studies using heterologous expression in both Xenopus laevis oocytes and mammalian kidney cells, as well as molecular studies involving protein-protein interaction both in ..
  9. Molecular Physiology of y-Aminobutyric Acid Transporters
    Sepehr Eskandari; Fiscal Year: 2012
    ..We will express the GABA transporters in Xenopus laevis oocytes in order to address the following Specific Aims: (1) To combine electrophysiological and electron ..
  10. Studies with Nicotinic Null Mutant Mice
    Michael J Marks; Fiscal Year: 2013
    ..made towards understanding the structure and function of neuronal nAChRs using expression systems (cell lines, Xenopus laevis oocytes)...
  11. Identify, Characterize &Regulate Intermediate Conductance K Channels in Kidney
    JOHN QIANG LENG; Fiscal Year: 2013
    ..that coassemble with ROMK subunits to form an IK channel by using standard expression screening techniques in Xenopus laevis oocytes...
  12. PIETER ERNST SMITH; Fiscal Year: 2014
    ..detailed information on the intracellular behavior of A[unreadable] by performing NMR experiments in living Xenopus laevis oocytes...
  13. Enabling Xenopus oocytes and embryos to perform RNAi
    Michael D Sheets; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Although Xenopus laevis is a powerful model organism that has provided critical mechanistic insights into vertebrate development, cell biology and neural biology its utility has been limited ..
  14. Jacques Robert; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Xenopus laevis is one of the best ectothermic vertebrate models for studying the phylogeny and ontogeny of the immune system. The evolutionary distance of X...
  15. Illuminating the process of rod outer segment morphogenesis
    Yoshikazu Imanishi; Fiscal Year: 2013
    ..proteins in rod photoreceptors and track their movements via confocal and two-photon microscopy in living Xenopus laevis tadpoles. By using this method, we propose: Aim1...
  16. Reprogramming Cells to Enable Limb Regeneration
    JONATHAN M SLACK; Fiscal Year: 2012
    ..Tadpoles of the frog Xenopus laevis are normally able to regenerate their limbs following amputation at early developmental stages but not at ..
  17. Loren W Runnels; Fiscal Year: 2016
    ..We have found in Xenopus Laevis that depletion of TRPM7, the first ion channel discovered to have its own kinase domain, results in embryos ..
  18. Cellular basis of visually-guided behavior during development
    Carlos D Aizenman; Fiscal Year: 2012
    ..Our proposal focuses on the developing optic tectum of the Xenopus laevis tadpole as a model system to address these issues...
  19. Investigating the role of leptin in larval growth and limb development in Xenopus
    ERICA CRESPI; Fiscal Year: 2009
    ..leptin on early developmental processes, including limb bud growth and differentiation, in the South African clawed frog (Xenopus laevis)...
  20. CHRISTOPHER KIRK THOMPSON; Fiscal Year: 2014
    ..approach to studying molecular and cellular mechanisms that govern the development of the visual system in Xenopus laevis tadpoles, including in vivo time-lapse 2 photon imaging, in vivo electrophysiological recordings of visual ..
  21. Targets of a cytidine deaminase required for left-right axis in Xenopus
    Alin Vonica; Fiscal Year: 2010
    ..subunit 2, XA2) in a genomic screen for factors regulated by nodal-type TGF-[unreadable] signaling in Xenopus laevis embryos...
  22. Wade H Powell; Fiscal Year: 2014
    ..Frogs are extremely insensitive to TCDD toxicity, and AHRs from Xenopus laevis (African clawed frog) bind TCDD with >20-fold lower affinity than the AHR from a highly sensitive mouse strain...
  23. Using shared mechanisms of morphogenesis to study neural tube defects
    JESSICA LEE SULLIVAN-BROWN; Fiscal Year: 2012
    ..Molecular and cellular mechanisms will be dissected in C. elegans and in the frog, Xenopus laevis (X. laevis) using the complementary strengths of each model system...
  24. María Isabel Domínguez; Fiscal Year: 2014
    ..The CK2 phosphorylation site on Dvl will be identified, and its function in Dvl regulation ascertained in Xenopus laevis embryos...
  25. Identification of Mechanically Sensitive Proteins in Early Development
    Douglas W DeSimone; Fiscal Year: 2013
    ..The mesendoderm of Xenopus laevis gastrula stage embryos undergoes a collective form of cell migration that requires both cell-cell cohesion and ..
  26. Lance A Davidson; Fiscal Year: 2014
    ..We will use an established toolkit consisting of three elements: 1) the aquatic frog Xenopus laevis for direct modulation of protein function and gene expression;2) high resolution confocal microscopy to ..
  27. Neural substrates for matching hearing to utterance
    Darcy B Kelley; Fiscal Year: 2012
    ..communication through exploration of a well-established model system: vocal communication in the South African clawed frog, Xenopus laevis...
  28. Lipid Signaling During Fertilization
    Bradley J Stith; Fiscal Year: 2010
    ..Today) suggests roles for phospholipase D and autotaxin in fertilization in an NIH-recognized model system (Xenopus laevis)...
  29. Rebecca W Heald; Fiscal Year: 2014
    ..To study mechanisms of mitosis we use assays based on cytoplasmic extracts prepared from eggs of the frog Xenopus laevis that can recapitulate mitotic spindle assembly and chromosome condensation and segregation in vitro...
  30. Identification of Binding Proteins of the Xenopus Morphogenetic Factor Tumorhead
    Edwin E Traverso; Fiscal Year: 2012
    ..Binding Proteins of the Xenopus Morphogenetic Factor Tumorhead Tumorhead (TH) is a morphogenetic factor from Xenopus laevis that has been implicated in the regulation of the processes of cell proliferation and differentiation during ..
  31. Natalia Y Kedishvili; Fiscal Year: 2016
    ..2, that is highly active as an all-trans-retinol dehydrogenase and is critical for embryonic development in Xenopus laevis. Importantly, there appears to be a functional equivalent of the frog rdhe2 in mammals, which exhibits an all-..
  32. Systems Architecture And Dynamical Behaviors of the Kinases That Drive M-Phase
    JOSEPH RICHARD POMERENING; Fiscal Year: 2013
    ..oscillation of CDK1 activity, and identifying and testing the functional interactions between them using Xenopus laevis egg extracts...
  33. Hazel L Sive; Fiscal Year: 2016
    ..proposal are to understand the mechanisms underlying formation of the vertebrate primary mouth, using the frog Xenopus laevis as a model...
  34. Development and Plasticity of a Retinotectal System
    Mu ming Poo; Fiscal Year: 2012
    The retinotectal system of Xenopus laevis is used as a model system for studying the development of topographically ordered projections in the nervous system...
  35. The role of Sox21 in neural development
    ELENA M CASEY; Fiscal Year: 2012
    ..factors during vertebrate neurogenesis, we are characterizing the function of the SoxB2 protein, Sox21, in Xenopus laevis. The ease of manipulating the Xenopus embryo will be exploited to test our hypotheses...
  36. Structural mechanisms of Mcm10 in DNA replication
    Brandt F Eichman; Fiscal Year: 2010
    ..Preliminary results from our laboratory have defined the overall domain architecture of Mcm10 from Xenopus laevis, and have identified the regions that interact with DNA and pol a...
  37. Hironori Funabiki; Fiscal Year: 2016
    ..Chromatin binding is directly coupled to activation of the kinase activity of Aurora B. In Xenopus laevis egg extracts, this activation mechanism is critical for spindle assembly...
  38. Nkx2-5 and congenital heart defects in Xenopus
    Daniel L Weeks; Fiscal Year: 2013
    ..have been studied to good advantage in a variety of system, including mouse, chicken, fly, fish and the frog Xenopus laevis. The regulatory division of labor in frog falls to three members of this family, Nkx2-5, Nkx2-3 and Nkx2-10 (..
  39. RACHEL KATHERINE MILLER; Fiscal Year: 2016
    ..Using Xenopus laevis (frog) embryos, supplemented in some contexts with embryos of Danio rerio (zebrafish), this proposal first ..
  40. Jerry D Glickson; Fiscal Year: 2016
    ..In Aim 2 we will directly measure the inhibitory effect of LND on MCT1 and MCT4 expressed in Xenopus laevis and will also evaluate the effect of LND on isolated liver and cardiac mitochondria and on permeabilized DB1 ..
  41. Susumu Tomita; Fiscal Year: 2014
    ..We will also examine structure and functional analysis of NETO2 and kainate receptors using Xenopus laevis oocyte as a model system...
  42. Fei Wang; Fiscal Year: 2014
    ..pathway, thereby negatively regulating the BMP pathway, and is necessary for neural development of hESCs and Xenopus laevis. In this research plan, we aim to explore how this kinase controls proteasomal degradation of BMPR-Is in hESCs ..
  43. Wnt Signaling in Xenopus Embryonic Development
    Sergei Y Sokol; Fiscal Year: 2010
    ..This application concerns the analysis of molecular mechanisms of Wnt signaling in embryonic cells of Xenopus laevis. Wnt signaling pathways play a major role in the control of cell proliferation, cell polarity and cell fate ..
  44. Network-directed discovery of disease genes
    Edward M Marcotte; Fiscal Year: 2012
    ..tube defect genes, and Specific Aim 3 focused on the experimental testing in the model vertebrate animal Xenopus laevis of genes deemed most likely to be associated with human neural tube defects, using first studies of expression ..
  45. The transcriptional control and function of proton-secreting cells
    Ian K Quigley; Fiscal Year: 2013
    ..This application proposes to study a novel experimental model, the proton-secreting cells of the Xenopus laevis embryonic skin, which are thought to mediate pH homeostasis of the embryo...
  46. NICHOLAS R MARSH-ARMSTRONG; Fiscal Year: 2015
    ..The proposed studies will employ two vertebrate animal models, Mus musculus and Xenopus laevis, taking advantages of experimental approaches optimal in each, including live imaging in the latter...
  47. Exploring the role of the central amygdala in vocalization
    IAN CHRISTOPHER HALL; Fiscal Year: 2013
    ..I will study this problem in a powerful model system (Xenopus laevis) in which vocal communication is well understood and the hindbrain vocal pattern generating circuit is mapped;..
  48. Molecular mechanism of FSHD pathology
    Peter L Jones; Fiscal Year: 2011
    ..The system for these studies is the vertebrate developmental model organism, Xenopus laevis (African clawed frog)...
  49. Role of Ubp-M and H2A deubiquitination in chromatin and cellular function
    Hengbin Wang; Fiscal Year: 2012
    ..Our preliminary studies indicate that Ubp-M regulates early embryogenesis in Xenopus laevis and is highly expressed in ovarian and breast cancer cells, underscoring the importance to determine the ..
  50. p120-catenin sub-family functions
    Pierre D McCrea; Fiscal Year: 2010
    ..For our studies, we will predominantly employ Xenopus laevis (frog) embryos...
  51. The Role of the Activity-Regulated GTPase Rem2 in Dendrite Development
    AMY ELIZABETH GHIRETTI; Fiscal Year: 2013
    ..To explore the role of Rem2 in such activity-dependent changes in morphology in vivo, the optic tectum of Xenopus laevis tadpoles, a well-characterized experimental system, will be used to identify how Rem2 participates in the ..
  52. Genevieve Abbruzzese; Fiscal Year: 2014
    ..In Xenopus laevis, CNC migration requires the cell surface metalloprotease ADAM13, which has a dual function in the CNC...
  53. Nikolai O Artemyev; Fiscal Year: 2016
    ..and lipid modifications in transducin targeting, membrane mobility and interdisc transfer using transgenic Xenopus laevis expressing mutant EGFP-fused Gat1 subunits in rod photoreceptors...
  54. PETER DEANE CALVERT; Fiscal Year: 2016
    ..protein probes or fusions of endogenous proteins in retinal photoreceptors will be expressed in transgenic Xenopus laevis or mouse photoreceptors...
  55. Development of Xenopus as a Model to Study Congenital Heart Disease
    Ann F Ramsdell; Fiscal Year: 2011
    ..achieve this, the candidate has established an experimentally-induced heterotaxy model in embryos of the frog, Xenopus laevis. The heterotaxy embryos exhibit abnormal cardiac and visceral organ L-R asymmetries that are accompanied by ..
  56. Chenbei Chang; Fiscal Year: 2015
    ..In this project, gastrulation movements in African clawed frog Xenopus laevis will be used as the model system to assess the roles of Abl and Arg in morphogenesis...
  57. Aaron F Straight; Fiscal Year: 2014
    ..nature of this inhibitory activity we replicated early studies, which had been performed in intact embryos, in Xenopus laevis egg extracts and showed similar DNA concentration dependent transcriptional repression...
  58. Signaling Mechanisms Coordinating Cell Fate Determination and Morphogenesis
    Daniel Weinstein; Fiscal Year: 2010
    ..In this application, we propose studies in embryos of the frog, Xenopus laevis, to define the mechanisms underlying the regulation of these processes by Ctrl...
  59. Susana Cohen-Cory; Fiscal Year: 2016
    ..In the proposed studies real-time imaging of neurons in developing Xenopus laevis embryos and state-of-the-art gain- and loss-of-function approaches will be used chronically and acutely ..
  60. Hans G Othmer; Fiscal Year: 2016
    ..in the wing disc of Drosophila, an (3) studies on dorsal-ventral patterning in the African frog Drosophila, Xenopus laevis. The aims under (1) are to further advance our understanding of the role of stochastic fluctuations and the ..
  61. A genome assembly for Xenopus laevis
    DANIEL SOLEYMAN ROKHSAR; Fiscal Year: 2013
    ..here to complement the genome assembly of Xenopus tropicalis with a gene and protein level genome assembly for Xenopus laevis. The allotetraploid Xenopus laevis is in wider use than the smaller, diploid Xenopus tropicalis, because of ..
  62. Plasticity and Regulation in Xenopus Anterior-Posterior Patterning
    Margaret S Saha; Fiscal Year: 2013
    ..Here we employ the classic amphibian embryological system of Xenopus laevis to examine regulative ability during early embryogenesis...
  63. Johannes Walter; Fiscal Year: 2014
    ..of vertebrate DNA replication, the applicant's laboratory employs a soluble cell-free system derived from Xenopus laevis eggs...
  64. MARC WALLACE KIRSCHNER; Fiscal Year: 2016
    ..vertebrate embryonic development leading to major ectodermal, mesodermal, and endodermal cell types, using the Xenopus laevis model system...
  65. Gufa Lin; Fiscal Year: 2014
    ..In ongoing studies on limb regeneration in the anuran amphibian, Xenopus laevis, we have successfully stimulated limb regenerate by transplantation of limb progenitor cells in a fibrin gel ..
  66. DANIEL SOLEYMAN ROKHSAR; Fiscal Year: 2016
    ..improvement of both the short range, and long range (chromosome level) assemblies of Xenopus tropicalis and Xenopus laevis. To achieve new insights into the function of both coding and non-coding DNA in the Xenopus clade, and add new ..
  67. Michael D Sheets; Fiscal Year: 2014
    ..While progress has been achieved in understanding Xenopus laevis development from a transcriptional point of view, significantly less is known about the translation of mRNA ..
  68. INHIBITION OF NONERYTHROID SPECTRIN BY ANTISENSE RNA
    Randall Moon; Fiscal Year: 1993
    ..is to use antisense RNA techniques to cause defects in alpha-fodrin during muscle development in the frog Xenopus laevis. This technique involves cloning an alpha-fodrin cDNA in an antisense orientation under control of one of ..
  69. Automated Analysis of Learning and Memory for Neuro-Developmental Studies
    Michael Levin; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Xenopus laevis is an extremely powerful system in which to study the genetics and biophysics of developmental morphogenesis...
  70. Group II Intron-Based Gene Targeting Methods for Xenopus
    Alan Lambowitz; Fiscal Year: 2009
    ..provided by applicant): We propose to develop efficient group II intron-based gene targeting methods for Xenopus laevis and Xenopus tropicalis...
  71. Rebecca W Heald; Fiscal Year: 2015
    ..First, we can compare Xenopus laevis to the smaller, related species Xenopus tropicalis, which lays smaller eggs and has proportionally smaller ..
  72. KERATIN GENE EXPRESSION DURING XENOPUS DEVELOPMENT
    LEO MILLER; Fiscal Year: 1992
    The adult epidermis of the frog, Xenopus laevis, is formed at metamorphosis. During this period the tadpole's two cell layered epidermis is replaced by a stratified keratinized epithelium typically found in the adults of most vertebrates...
  73. MODELING CALCIUM WAVES IN MATURE XENOPUS LAEVIS OOCYTES
    JERRY HEDRICK; Fiscal Year: 2000
    ..In the mature Xenopus laevis oocyte, as in mammalian species, the inositol phospholipid cascade has been demonstrated to be the major ..
  74. Photoreceptor Degeneration Assay-Transgenic Xenopus(RMI)
    Nicholas Marsh Armstrong; Fiscal Year: 2005
    ..We have developed lines of Xenopus laevis in which transgenes both cause rod photoreceptors to degenerate in a manner that resemble human retinitis ..
  75. DEVELOPMENT OF THE XENOPUS ACOUSTICO-VESTIBULAR SYSTEM
    ELBA SERRANO; Fiscal Year: 2002
    ..Experiments will focus on the auditory and vestibular hair cells of the amphibian, Xenopus laevis. The proposed research will exploit the advantages that Xenopus offers as a classical system for developmental ..
  76. Using Chemical Biology to Study the Small GTPase Ra(RMI)
    Karsten Weis; Fiscal Year: 2005
    ..growing body of evidence to support this hypothesis from experiments performed using extracts from the eggs of Xenopus laevis, however the details of how this process works in living cells are poorly understood...
  77. PROTEIN BINDING DOMAINS ON EUKARYOTIC 5S RRNA AND RDNA
    Paul Huber; Fiscal Year: 2000
    Protein-nucleic acid interactions are the fundamental basis for the control of genetic expression. Xenopus laevis contains two 5S rRNA multigene families that provide a simple, tractable model for the de- velopmental regulation of ..

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