chicken

Summary

Alias: chickens, Gallus gallus, dwarf Leghorn chickens, red junglefowl, Gallus domesticus, Gallus gallus domesticus, bantam

Top Publications

  1. doi Whole-genome resequencing reveals loci under selection during chicken domestication
    Carl Johan Rubin
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 75123 Uppsala, Sweden
    Nature 464:587-91. 2010
  2. ncbi Vertebrate neurogenesis is counteracted by Sox1-3 activity
    Magdalena Bylund
    Ludwig Institute of Cancer Research, Karolinska Institute, Box 240, SE 171 77 Stockholm, Sweden
    Nat Neurosci 6:1162-8. 2003
  3. pmc USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier
    Suming Huang
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
    Mol Cell Biol 27:7991-8002. 2007
  4. ncbi Control of planar divisions by the G-protein regulator LGN maintains progenitors in the chick neuroepithelium
    Xavier Morin
    Institute of Developmental Biology of Marseille Luminy, Centre National de la Recherche Scientifique UMR 6216, Case 907, Campus de Luminy, 13288 Marseille Cedex9, France
    Nat Neurosci 10:1440-8. 2007
  5. pmc Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens
    Dominic Wright
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 5:e1000512. 2009
  6. doi Avian SERPINB11 gene: a marker for ovarian endometrioid cancer in chickens
    Whasun Lim
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, 599 Gwanak Ro, Gwanak Gu, Seoul, Korea
    Exp Biol Med (Maywood) 237:150-9. 2012
  7. pmc A complex genomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chicken
    Ben Dorshorst
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 7:e1002412. 2011
  8. ncbi Isolation of chicken vasa homolog gene and tracing the origin of primordial germ cells
    N Tsunekawa
    Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
    Development 127:2741-50. 2000
  9. ncbi Somatic hyperconversion diversifies the single Vh gene of the chicken with a high incidence in the D region
    C A Reynaud
    Basel Institute for Immunology, Switzerland
    Cell 59:171-83. 1989
  10. ncbi Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
    H Roelink
    Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    Cell 81:445-55. 1995

Research Grants

  1. Eric S Johnson; Fiscal Year: 2015
  2. In-ovo vaccination/avian influenza/bird/human
    DE CHU CHRISTOPHER TANG; Fiscal Year: 2010
  3. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
  4. A novel Salmonella vaccine to protect against extra intestinal pathogenic E. coli
    Melha Mellata; Fiscal Year: 2011
  5. Antimicrobial peptide resistance in Campylobacter jejuni
    Jun Lin; Fiscal Year: 2010
  6. Fimbrial expression in Salmonella: regulation and coordination
    Steven Clegg; Fiscal Year: 2010
  7. Rebecca Lewis; Fiscal Year: 2015
  8. PEPTIDE BASED SALMONELLA VACCINE DELIVERY SYSTEM
    Lee Riley; Fiscal Year: 1999
  9. Malaria Erythrocyte Binding-like Genes &Host Specificity in a Natural Population
    RAVINDER NATH MARIUS SEHGAL; Fiscal Year: 2011
  10. In-ovo vaccination/avian influenza/bird/human
    DE CHU TANG; Fiscal Year: 2006

Patents

  1. TRANSLATIONAL DYSFUNCTION BASED THERAPEUTICS
  2. FGF MODULATION OF IN VIVO ANTIBODY PRODUCTION AND HUMORAL IMMUNITY
  3. A novel allergen and use thereof
  4. Novel anti-PAD4 antibody
  5. AVIAN CELLS FOR IMPROVED VIRUS PRODUCTION
  6. Extension or attraction accelerator of axon, Therapeutic agent for neurological disease or neurological injury, and scaffolding device
  7. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
  8. AVIAN CELLS FOR IMPROVED VIRUS PRODUCTION
  9. FGF MODULATION OF IN VIVO ANTIBODY PRODUCTION AND HUMORAL IMMUNITY
  10. METHOD OF DETECTING AVIAN NECROTIC ENTERITIS

Detail Information

Publications442 found, 100 shown here

  1. doi Whole-genome resequencing reveals loci under selection during chicken domestication
    Carl Johan Rubin
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE 75123 Uppsala, Sweden
    Nature 464:587-91. 2010
    ..alleles and candidate mutations that have had a prominent role in the domestication of chickens (Gallus gallus domesticus) and their subsequent specialization into broiler (meat-producing) and layer (egg-producing) chickens...
  2. ncbi Vertebrate neurogenesis is counteracted by Sox1-3 activity
    Magdalena Bylund
    Ludwig Institute of Cancer Research, Karolinska Institute, Box 240, SE 171 77 Stockholm, Sweden
    Nat Neurosci 6:1162-8. 2003
    ..These data suggest that the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins...
  3. pmc USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier
    Suming Huang
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
    Mol Cell Biol 27:7991-8002. 2007
    The insulator element at the 5' end of the chicken beta-globin locus acts as a barrier, protecting transgenes against silencing effects of adjacent heterochromatin...
  4. ncbi Control of planar divisions by the G-protein regulator LGN maintains progenitors in the chick neuroepithelium
    Xavier Morin
    Institute of Developmental Biology of Marseille Luminy, Centre National de la Recherche Scientifique UMR 6216, Case 907, Campus de Luminy, 13288 Marseille Cedex9, France
    Nat Neurosci 10:1440-8. 2007
    ..Hence, tight control of planar spindle orientation maintains neural progenitors in the neuroepithelium, and regulates the proper development of the nervous system...
  5. pmc Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens
    Dominic Wright
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 5:e1000512. 2009
    Pea-comb is a dominant mutation in chickens that drastically reduces the size of the comb and wattles. It is an adaptive trait in cold climates as it reduces heat loss and makes the chicken less susceptible to frost lesions...
  6. doi Avian SERPINB11 gene: a marker for ovarian endometrioid cancer in chickens
    Whasun Lim
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, 599 Gwanak Ro, Gwanak Gu, Seoul, Korea
    Exp Biol Med (Maywood) 237:150-9. 2012
    ..We identified SERPINB11 as a novel estrogen-induced gene in chickens during oviduct development...
  7. pmc A complex genomic rearrangement involving the endothelin 3 locus causes dermal hyperpigmentation in the chicken
    Ben Dorshorst
    Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 7:e1002412. 2011
    Dermal hyperpigmentation or Fibromelanosis (FM) is one of the few examples of skin pigmentation phenotypes in the chicken, where most other pigmentation variants influence feather color and patterning...
  8. ncbi Isolation of chicken vasa homolog gene and tracing the origin of primordial germ cells
    N Tsunekawa
    Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
    Development 127:2741-50. 2000
    To obtain a reliable molecular probe to trace the origin of germ cell lineages in birds, we isolated a chicken homolog (Cvh) to vasa gene (vas), which plays an essential role in germline formation in Drosophila...
  9. ncbi Somatic hyperconversion diversifies the single Vh gene of the chicken with a high incidence in the D region
    C A Reynaud
    Basel Institute for Immunology, Switzerland
    Cell 59:171-83. 1989
    The chicken heavy chain locus contains a single JH segment and a unique functional VH gene (VH1) 15 kb upstream, with approximately 15 D elements in between...
  10. ncbi Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
    H Roelink
    Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    Cell 81:445-55. 1995
    ....
  11. ncbi Craniofacial development in the talpid3 chicken mutant
    Paul Buxton
    Department of Craniofacial Development, GKT Dental Institute, Floor 27 Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Differentiation 72:348-62. 2004
    The talpid(3) chicken mutant has a pleiotropic phenotype including polydactyly and craniofacial abnormalities...
  12. ncbi Wnt signals provide a timing mechanism for the FGF-retinoid differentiation switch during vertebrate body axis extension
    Isabel Olivera-Martinez
    Division of Cell and Developmental Biology, College of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Development 134:2125-35. 2007
    ....
  13. pmc Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation
    Ana M Pasapera
    Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 188:877-90. 2010
    ....
  14. pmc Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens
    Shumao Lin
    Guangdong Provincial Key Laboratory of Agro animal Genomics and Molecular Breeding, Guangzhou, Guangdong, China
    BMC Genomics 13:306. 2012
    ..hormone receptor (GHR) gene results in the inhibition of skeletal muscle growth and fat deposition in dwarf chickens. We used microarray techniques to determine microRNA (miRNA) and mRNA expression profiles of GHR in the skeletal ..
  15. ncbi Avian keratin genes. I. A molecular analysis of the structure and expression of a group of feather keratin genes
    R B Presland
    Department of Biochemistry, University of Adelaide, South Australia
    J Mol Biol 209:549-59. 1989
    The nucleotide sequence of the four complete chicken feather keratin genes A to D contained in the previously isolated recombinant lambda CFK1 has been determined...
  16. pmc Characterization of a beta-actin mRNA zipcode-binding protein
    A F Ross
    Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655, USA
    Mol Cell Biol 17:2158-65. 1997
    ..Screening of a chicken cDNA library resulted in isolation of several clones providing a DNA sequence encoding a 67...
  17. ncbi A non-canonical photopigment, melanopsin, is expressed in the differentiating ganglion, horizontal, and bipolar cells of the chicken retina
    Sayuri Tomonari
    Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, Tokushima, Japan
    Dev Dyn 234:783-90. 2005
    ..Here we show that two types of melanopsin transcripts are expressed in the developing chicken retina...
  18. pmc The transcription factor Engrailed-2 guides retinal axons
    Isabelle Brunet
    CNRS UMR 8542, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Nature 438:94-8. 2005
    ..The differential guidance of nasal and temporal axons reported here suggests that En-2 may participate directly in topographic map formation in the vertebrate visual system...
  19. ncbi BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage
    Boudewijn P T Kruithof
    Experimental and Molecular Cardiology Group, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Dev Biol 295:507-22. 2006
    ..We conclude that the epicardial/myocardial lineage decisions are mediated by an extrinsic, inductive mechanism, which is determined by the position of the cells in the pericardial mesoderm...
  20. pmc Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin
    Xiao Peng
    Department of Biochemistry, University of Iowa Roy J Carver College of Medicine, Iowa City, IA 52242, USA
    J Cell Sci 123:567-77. 2010
    ..Thus, our study identifies vinculin as a novel regulator of E-cadherin function and provides important new insight into the dynamic regulation of adherens junctions...
  21. doi Matrix metalloproteinase 9/gelatinase B is required for neural crest cell migration
    Efrat Monsonego-Ornan
    The Institute of Biochemistry and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot, Israel
    Dev Biol 364:162-77. 2012
    ..Altogether, our study reveals MMP9 as a novel effector which is required for NCC delamination and migration...
  22. pmc Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin
    J Balsamo
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    J Cell Biol 134:801-13. 1996
    ..In this manner the GalNAcPTase-proteoglycan interaction may play a major role in morphogenetic cell and tissue interactions during development...
  23. pmc Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation
    C Kutzleb
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    J Cell Biol 143:795-813. 1998
    ..cDNAs from chicken, human, and mouse predict acidic proteins of 42 kD that display a pattern of sequence cassettes with high inter-..
  24. ncbi Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome
    B G Bruneau
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA
    Dev Biol 211:100-8. 1999
    ....
  25. ncbi Conservation of biological properties of the CD40 ligand, CD154 in a non-mammalian vertebrate
    Clive A Tregaskes
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Dev Comp Immunol 29:361-74. 2005
    ..To determine whether these functions were conserved in a non-mammalian species, a putative chicken CD 154 cDNA was used to make an oligomeric fusion protein, and to raise monoclonal antibodies...
  26. ncbi Differential expression of Sox2 and Sox3 in neuronal and sensory progenitors of the developing inner ear of the chick
    Joana Neves
    Biologia del Desenvolupament, Departament de Ciències Experimentals i de la Salut DCEXS, Universitat Pompeu Fabra, Parc de Recerca Biomédica de Barcelona PRBB, 08003 Barcelona, Spain
    J Comp Neurol 503:487-500. 2007
    ..Our data are consistent with a role for SOX2 in specifying a population of otic progenitors committed to a neural fate, giving rise to neurons and hair cells...
  27. pmc Differential expression of alpha 2 macroglobulin in response to dietylstilbestrol and in ovarian carcinomas in chickens
    Whasun Lim
    Department of Agricultural Biotechnology, Seoul National University, 599 Gwanak Ro, Gwanak Gu, Seoul 151 921, Korea
    Reprod Biol Endocrinol 9:137. 2011
    ..In chickens, A2M has been identified and characterized biochemically, but little is known of its functional role(s) in the ..
  28. pmc Chicken pleiotrophin: regulation of tissue specific expression by estrogen in the oviduct and distinct expression pattern in the ovarian carcinomas
    Jin Young Lee
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    PLoS ONE 7:e34215. 2012
    ..However, little is known about the PTN gene in chickens. In the present study, we found chicken PTN to be highly conserved with respect to mammalian PTN genes (91-92...
  29. doi Sex- and tissue-specific expression of "similar to nothepsin" and cathepsin D in relation to egg yolk formation in Gallus gallus
    M Bourin
    Institut National de la Recherche Agronomique, UR83 Recherches Avicoles, F 37380 Nouzilly, France
    Poult Sci 91:2288-93. 2012
    ..To gain insight into the specificities of expression of both cathepsin D and "similar to nothepsin" in Gallus gallus, we compared their distribution in various tissues, in male and females...
  30. ncbi A study of association between genetic markers in candidate genes and reproductive traits in one generation of a commercial broiler breeder hen population
    I C Dunn
    Roslin Institute, Roslin, Midlothian EH25 9PS, Scotland, UK
    Heredity (Edinb) 92:128-34. 2004
    ..egg production, number of double-yolked eggs and age at first egg in a single generation of a broiler breeder (Gallus gallus) pedigree dam line...
  31. pmc The early isoform of disabled-1 functions independently of Reelin-mediated tyrosine phosphorylation in chick retina
    Zhihua Gao
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, AB, Canada
    Mol Cell Biol 30:4339-53. 2010
    ..Our results demonstrate a role for Dab1-E in the maintenance of the retinal progenitor pool and determination of cell fate...
  32. ncbi Characterization and expression sites of newly identified chicken collectins
    Astrid Hogenkamp
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Graduate School of Animal Health, Utrecht University, P O Box 80 165, 3508 TD Utrecht, The Netherlands
    Mol Immunol 43:1604-16. 2006
    ..They have been found almost exclusively in mammals, with the exception of chicken MBL. Because of their important role in innate immunity, we sought to identify other collectins in chicken...
  33. pmc EphrinB2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation
    Tadayoshi Watanabe
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0192, Japan
    Proc Natl Acad Sci U S A 106:7467-72. 2009
    ..We here demonstrate that cMeso-1, the chicken homolog of mouse Mesp2, up-regulates EphA4 in the cells located posteriorly to a forming boundary...
  34. doi Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development
    Luis Óscar Sánchez-Guardado
    Department of Cell Biology, School of Science, University of Extremadura, Badajoz, Spain
    Dev Dyn 240:1475-92. 2011
    ..In this work, we performed a comprehensive study of chicken Meis genes using multiple approaches...
  35. pmc Occludin: a novel integral membrane protein localizing at tight junctions
    M Furuse
    Department of Information Physiology, National Institute for Physiological Sciences, Aichi, Japan
    J Cell Biol 123:1777-88. 1993
    ..These findings revealed that an integral membrane protein localizing at tight junctions is now identified, which we designated as "occludin."..
  36. pmc Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells
    Kazuhiko Yamamoto
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama 701 0192, Japan
    Mol Cell Biol 23:5421-30. 2003
    ..To elucidate the roles of FA genes in HR, we disrupted the FANCG/XRCC9 locus in the chicken B-cell line DT40...
  37. pmc CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    Maximina H Yun
    Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 459:460-3. 2009
    ....
  38. pmc Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shape
    Nathan M Young
    Department of Orthopaedic Surgery, University of California San Francisco, 2550 23rd Street, San Francisco, CA 94110, USA
    Development 137:3405-9. 2010
    ..Together, these results provide novel insight into the generation of facial morphology, and demonstrate the value of quantifying variation for our understanding of development and disease...
  39. pmc CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold
    Tatsuya Nishino
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Cell 148:487-501. 2012
    ..These data suggest that the CENP-T-W-S-X complex forms a unique nucleosome-like structure to generate contacts with DNA, extending the "histone code" beyond canonical nucleosome proteins...
  40. ncbi Aromatase mRNA in the extragonadal tissues of chickens with the henny-feathering trait is derived from a distinctive promoter structure that contains a segment of a retroviral long terminal repeat. Functional organization of the Sebright, Leghorn, and Cam
    H Matsumine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8857
    J Biol Chem 266:19900-7. 1991
    ..that causes the expression of aromatase activity and accumulation of aromatase mRNA in extragonadal tissues of chickens. The current studies establish that the aromatase gene is not amplified and is organized similarly in control (..
  41. pmc Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains
    M D Schaller
    Department of Microbiology, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Cell Biol 130:1181-7. 1995
    ..we have established that the cytoplasmic domain of the beta 1 integrin can bind to paxillin and pp125FAK from chicken embryo cell lysates...
  42. ncbi Repulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance
    Eiji Matsunaga
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7102, Equipe Développement Neuronal, Universite Pierre et Marie Curie Paris 6, 75005 Paris, France
    J Neurosci 26:6082-8. 2006
    ..Our work provides the first evidence for a role for RGMs in axon guidance in vivo. In addition, these results suggest that RGMa exerts multiple functions during neural development...
  43. doi Functional mode of FoxD1/CBF2 for the establishment of temporal retinal specificity in the developing chick retina
    Hiroo Takahashi
    National Institute for Basic Biology, Higashiyama, Myodaiji cho, Okazaki, Japan
    Dev Biol 331:300-10. 2009
    ....
  44. doi VA opsin-based photoreceptors in the hypothalamus of birds
    Stephanie Halford
    Circadian and Visual Neuroscience, Nuffield Laboratory of Ophthalmology, University of Oxford, Headley Way, Oxford OX3 9DU, UK
    Curr Biol 19:1396-402. 2009
    ..Here, we report the isolation of VA opsin from chicken and show that the two isoforms spliced from this gene (cVAL and cVA) are capable of forming functional ..
  45. doi Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification
    Joana Neves
    CEXS, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, C Dr Aiguader 88, 08003 Barcelona, Spain
    Development 138:735-44. 2011
    ..However, the underlying mechanism of Notch function is unknown. Our results show that in the chicken otic vesicle, the Sox2 expression domain initially contains the nascent patches of Jag1 expression but, later on, ..
  46. pmc Identification and characterization of a novel cytoskeleton-associated pp60src substrate
    H Wu
    Department of Microbiology, Health Sciences Center, Charlottesville, Virginia 22908
    Mol Cell Biol 11:5113-24. 1991
    ..The multidomain structure of p80/85 and its colocalization with F-actin in normal and src-transformed cells suggest that these proteins may associate with components of the cytoskeleton and contribute to organization of cell structure...
  47. pmc Three-dimensional structures of avidin and the avidin-biotin complex
    O Livnah
    Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel
    Proc Natl Acad Sci U S A 90:5076-80. 1993
    ..Unexpectedly, a residual N-acetylglucosamine moiety was detected in the deglycosylated avidin monomer by difference Fourier synthesis...
  48. pmc An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells
    Helfrid Hochegger
    Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Cell Biol 178:257-68. 2007
    ..To investigate this, we generated chicken DT40 mutants, in which an analog-sensitive mutant cdk1 as replaces the endogenous Cdk1, allowing us to ..
  49. ncbi Neural crest emigration from the neural tube depends on regulated cadherin expression
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Development 125:2963-71. 1998
    ..In the chicken embryo, the early neural tube expresses two cadherins, N-cadherin and cadherin-6B (cad6B), in the dorsal-most ..
  50. ncbi Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis
    X M Zhang
    Department of Ophthalmology, Jules Stein Eye Institute and Molecular Biology Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    Dev Biol 233:271-90. 2001
    ..We propose a model in which ventrally derived Shh signals and dorsally restricted BMP4 signals act antagonistically to regulate the growth and specification of the optic primordium...
  51. ncbi Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33
    Y Goshima
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 376:509-14. 1995
    ..CRMP-62 appears to be an intracellular component of a signalling cascade initiated by an unidentified transmembrane collapsin-binding protein...
  52. ncbi Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development
    D Uwanogho
    Department of Craniofacial Development, UMDS, Guy s Hospital, London, UK
    Mech Dev 49:23-36. 1995
    Three chicken Sox (SRY-like box) genes have been identified that show an interactive pattern of expression in the developing embryonic nervous system...
  53. ncbi Sonic hedgehog mediates the polarizing activity of the ZPA
    R D Riddle
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 75:1401-16. 1993
    ..Like the ZPA, Sonic hedgehog expression leads to the activation of Hox genes. Sonic hedgehog thus appears to function as the signal for antero-posterior patterning in the limb...
  54. ncbi A male-specific role for SOX9 in vertebrate sex determination
    J Kent
    Centre for Molecular and Cellular Biology, The University of Queensland, Brisbane, Australia
    Development 122:2813-22. 1996
    ..plays in vertebrate sex determination, we have investigated its expression during gonad development in mouse and chicken embryos...
  55. ncbi The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor
    H Ohuchi
    Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, Japan
    Development 124:2235-44. 1997
    ..These results suggest that FGF10 is a key mesenchymal factor involved in the initial budding as well as the continuous outgrowth of vertebrate limbs...
  56. ncbi Initiation of neural induction by FGF signalling before gastrulation
    A Streit
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Nature 406:74-8. 2000
    ..We show that the organizer and some of its precursor cells produce a fibroblast growth factor signal, which can initiate, and is required for, neural induction...
  57. ncbi Molecular cloning and functional characterization of chicken toll-like receptors. A single chicken toll covers multiple molecular patterns
    A Fukui
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    J Biol Chem 276:47143-9. 2001
    ..Two types of TLR were cloned from a chicken bursa cDNA library using degenerate primers based on the consensus sequences of mouse and Drosophila Toll and ..
  58. ncbi FGF signaling is required for determination of otic neuroblasts in the chick embryo
    Berta Alsina
    Biologia del Desenvolupament, Departament de Ciències Experimentals i de la Salut DCEXS, Universitat Pompeu Fabra, 08003, Barcelona, Spain
    Dev Biol 267:119-34. 2004
    ..We suggest that FGF signaling in the otic epithelium is required for neuronal precursors to withdraw from cell division and irreversibly commit to neuronal fate...
  59. ncbi Molecular cloning, localization and circadian expression of chicken melanopsin (Opn4): differential regulation of expression in pineal and retinal cell types
    S S Chaurasia
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA
    J Neurochem 92:158-70. 2005
    ..Here, we report the cDNA cloning of chicken melanopsin and show its expression in retina, brain and pineal gland...
  60. doi The avian Z-linked gene DMRT1 is required for male sex determination in the chicken
    Craig A Smith
    Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Nature 461:267-71. 2009
    ..In the chicken and all other birds, the homogametic sex is male (ZZ) and the heterogametic sex is female (ZW)...
  61. pmc Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein
    Takahiro Yamashita
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Proc Natl Acad Sci U S A 107:22084-9. 2010
    ..Here we show that the chicken Opn5 (cOpn5m) is a UV-sensitive bistable pigment that couples with Gi subtype of G protein...
  62. pmc The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation
    F Buss
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QR, United Kingdom
    J Cell Biol 143:1535-45. 1998
    ..In this study we have cloned and sequenced a cDNA encoding a chicken intestinal brush border myosin VI...
  63. pmc The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision
    R T Yu
    Graduate School of Biostudies, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 97:2621-5. 2000
    ..These studies show that Tlx is a key component of retinal development and vision and an upstream regulator of the Pax2 signaling cascade...
  64. pmc Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens
    Chung Ming Chang
    UMR Génétique et Diversité Animales, INRA INA P G, Centre de Recherches de Jouy, 78352 Jouy en Josas, France
    BMC Genomics 7:19. 2006
    In chickens, three mutant alleles have been reported at the C locus, including the albino mutation, and the recessive white mutation, which is characterized by white plumage and pigmented eyes...
  65. ncbi Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh
    L Gimeno
    Instituto de Neurociencias de Alicante, CSIC UMH Campus de San Juan, Alicante, Spain
    Dev Dyn 236:2285-97. 2007
    ....
  66. pmc VEZF1 elements mediate protection from DNA methylation
    Jacqueline Dickson
    Section of Pathology and Gene Regulation, Faculty of Medicine, University of Glasgow, Western Infirmary, Glasgow, United Kingdom
    PLoS Genet 6:e1000804. 2010
    ....
  67. ncbi BLNK: a central linker protein in B cell activation
    C Fu
    Center for Immunology, Program in Molecular Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Immunity 9:93-103. 1998
    ..Hence, BLNK represents a central linker protein that bridges the B cell receptor-associated kinases with a multitude of signaling pathways and may regulate the biologic outcomes of B cell function and development...
  68. ncbi Two distinct subgroups of Group B Sox genes for transcriptional activators and repressors: their expression during embryonic organogenesis of the chicken
    M Uchikawa
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Mech Dev 84:103-20. 1999
    ..Screening of chicken genomic sequences for more Group B Sox genes identified two additional genes, Sox14 and Sox21...
  69. pmc Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
    M Ishiai
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570 8506, Japan
    J Exp Med 192:847-56. 2000
    ..Hence, these data suggest a functional overlap between BLNK and SLP-76, while emphasizing the difference in requirement for additional adaptor molecules in their targeting to GEMs...
  70. pmc Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage
    Michio Yoshimura
    Department of Radiation Genetics, CREST, Japan Science and Technology Laboratory, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell 24:115-25. 2006
    ..We disrupted POLQ, and its homologs HEL308 and POLN in chicken DT40 cells, and also created polq/hel308 and polq/poln double mutants...
  71. pmc SOX9 specifies the pyloric sphincter epithelium through mesenchymal-epithelial signals
    Brigitte Moniot
    Institut de Genetique Humaine, UPR 1142 CNRS, 141 rue de la Cardonille, 34396 Montpellier, Cedex 5, France
    Development 131:3795-804. 2004
    ..Our results suggest that SOX9 is necessary and sufficient to specify the pyloric sphincter epithelial properties...
  72. pmc Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
    M C Brown
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Syracuse, 13210, USA
    J Cell Biol 135:1109-23. 1996
    ....
  73. ncbi Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development
    Olov Andersson
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Dev Biol 311:500-11. 2007
    ....
  74. ncbi Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin
    A Marijke Keestra
    Department of Infectious Diseases and Immunology, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Mol Immunol 45:1298-307. 2008
    ..These results show that chickens express a functional TLR5 albeit with different flagellin sensing qualities compared to human TLR5...
  75. pmc Nonconserved tryptophan 38 of the cell surface receptor for subgroup J avian leukosis virus discriminates sensitive from resistant avian species
    Dana Kucerova
    Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Virol 87:8399-407. 2013
    ..Because no resistant chicken lines have been described until now, we compared the NHE1 amino acid sequences from permissive and resistant ..
  76. ncbi A cloned chicken lymphokine homologous to both mammalian IL-2 and IL-15
    R S Sundick
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 159:720-5. 1997
    ..importance of poultry and the lack of any IL-2 sequence data in lower vertebrates, we undertook to clone a chicken IL-2-like molecule...
  77. doi Chicken dapper genes are versatile markers for mesodermal tissues, embryonic muscle stem cells, neural crest cells, and neurogenic placodes
    Lúcia Elvira Alvares
    Department of Histology and Embryology, Institute of Biology, State University of Campinas UNICAMP, Sao Paulo, Brazil
    Dev Dyn 238:1166-78. 2009
    ..Searching for avian Dpr genes, we found that the chicken harbors a Dpr1 and a Dpr2 paralogue only...
  78. pmc The prosensory function of Sox2 in the chicken inner ear relies on the direct regulation of Atoh1
    Joana Neves
    CEXS, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    PLoS ONE 7:e30871. 2012
    ..In the present work, we used the chicken embryo and HEK293T cells to explore the regulation of Atoh1 by Sox2...
  79. ncbi Regulation of chamber-specific gene expression in the developing heart by Irx4
    Z Z Bao
    Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 283:1161-4. 1999
    ..Little is known of the molecular mechanisms by which these chambers are specified during embryogenesis. Here a chicken iroquois-related homeobox gene, Irx4, was identified that has a ventricle-restricted expression pattern at all ..
  80. ncbi Expression of the novel basic-helix-loop-helix transcription factor cMespo in presomitic mesoderm of chicken embryos
    A Buchberger
    Department of Cell and Molecular Biology, University of Braunschweig, Spielmannstrasse 7, 38106, Braunschweig, Germany
    Mech Dev 97:223-6. 2000
    We have identified a novel chicken gene, cMespo, which encodes a basic-helix-loop-helix (bHLH) protein with sequence homology to a subgroup of bHLH transcription factors that have been implicated in somitogenesis...
  81. doi Tyrosine hydroxylase is expressed during early heart development and is required for cardiac chamber formation
    Carmen Lopez-Sanchez
    Facultad de Medicina, Universidad de Extremadura, Badajoz, Spain
    Cardiovasc Res 88:111-20. 2010
    ..The aim of this study was to define the expression of TH during cardiac development and to unravel the role it may play in heart formation...
  82. doi Avian SERPINB11 gene: characteristics, tissue-specific expression, and regulation of expression by estrogen
    Whasun Lim
    World Class University Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea
    Biol Reprod 85:1260-8. 2011
    ..the present study, the SERPINB11 gene was cloned, and its expression profile was analyzed in various tissues from chickens. The chicken SERPINB11 gene has an open reading frame of 1346 nucleotides that encode a protein of 388 amino ..
  83. pmc Paladin is an antiphosphatase that regulates neural crest cell formation and migration
    Julaine Roffers-Agarwal
    Department of Genetics, Cell Biology and Development, 6 160 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 371:180-90. 2012
    ..Our work identifies a novel regulator of phosphorylation status that provides an additional layer of regulation in the neural crest...
  84. ncbi Delta-like 1 and lateral inhibition during hair cell formation in the chicken inner ear: evidence against cis-inhibition
    Elena Chrysostomou
    University College London, The Ear Institute, 332 Gray s Inn Road, London WC1X 8EE, UK
    Development 139:3764-74. 2012
    ..Here, we transfected the chicken inner ear with a fluorescent reporter that includes elements of the mammalian Hes5 promoter to monitor Notch ..
  85. pmc A sexual ornament in chickens is affected by pleiotropic alleles at HAO1 and BMP2, selected during domestication
    Martin Johnsson
    IFM Biology, Avian Behavioural Genomics and Physiology Group, Linkoping University, Linkoping, Sweden
    PLoS Genet 8:e1002914. 2012
    ..Using three separate intercrosses between wild and domestic chickens, a locus affecting comb mass (a sexual ornament in the chicken) and several fitness traits (primarily medullary ..
  86. ncbi Avian keratin genes. II. Chromosomal arrangement and close linkage of three gene families
    R B Presland
    Department of Biochemistry, University of Adelaide, South Australia
    J Mol Biol 209:561-76. 1989
    We describe the isolation and characterization of a set of overlapping cosmid clones that contain chicken keratin genes...
  87. ncbi Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Development 121:1321-32. 1995
    ..c-cad6B and c-cad7, expressed by neural crest cells at their premigratory and migratory stages, respectively, in chicken embryos...
  88. ncbi A molecular pathway determining left-right asymmetry in chick embryogenesis
    M Levin
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 82:803-14. 1995
    ..Together, these observations identify a cascade of molecular asymmetry in that determines morphological LR asymmetry in the chick embryo...
  89. ncbi Identification and analysis of the expression of CD8 alpha beta and CD8 alpha alpha isoforms in chickens reveals a major TCR-gamma delta CD8 alpha beta subset of intestinal intraepithelial lymphocytes
    C A Tregaskes
    Institute for Animal Health, Compton, Berks, United Kingdom
    J Immunol 154:4485-94. 1995
    ..and CD8 beta-chains revealed that the vast majority of the CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8 alpha- and CD8 beta-chains...
  90. ncbi The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
    T Serafini
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452
    Cell 78:409-24. 1994
    ..elegans. This homology suggests that growth cones in the vertebrate spinal cord and the nematode are responsive to similar molecular cues...
  91. pmc Specific activation in jun-transformed avian fibroblasts of a gene (bkj) related to the avian beta-keratin gene family
    M Hartl
    Institute of Biochemistry, University of Innsbruck, Austria
    Proc Natl Acad Sci U S A 92:11731-5. 1995
    ..Furthermore, the gene was expressed in quail or chicken fibroblast cultures that were freshly transformed by retroviral constructs carrying various viral or cellular jun ..
  92. ncbi Chicken B-cell marker chB6 (Bu-1) is a highly glycosylated protein of unique structure
    C A Tregaskes
    Institute for Animal Health, Compton, Berkshire, RG20 7NN, UK
    Immunogenetics 44:212-7. 1996
    ..Its presence in chickens may be related to differences in the properties of B-cell development between chickens and mammalian species...
  93. ncbi Complementary domains of retinoic acid production and degradation in the early chick embryo
    E C Swindell
    Department of Biochemistry, Baylor College of Medicine, Houston, Texas, 77030, USA
    Dev Biol 216:282-96. 1999
    ..Localized regions of RA synthesis and degradation mediated by these two enzymes may therefore provide a mechanism to regulate RA homeostasis spatially in vertebrate embryos...
  94. ncbi Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin
    J Capdevila
    Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA
    Mol Cell 4:839-49. 1999
    ..Moreover, combinations of BMPs and AER factors are sufficient to distalize proximal limb cells. Our results unveil a novel set of proximal-distal regulatory interactions that establish and maintain outgrowth of the vertebrate limb...
  95. ncbi Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    B Wang
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 100:423-34. 2000
    ..can be perturbed by mutations of Gli3 in human genetic syndromes or by misregulation of Gli3 processing in the chicken mutant talpid2, producing a range of limb patterning malformations...
  96. ncbi A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation
    Taiping Chen
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:38746-54. 2002
    ..These findings suggest that Dnmt3a and Dnmt3a2 may have distinct DNA targets and different functions in development...
  97. ncbi Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes
    Colin Thorpe
    Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA
    Arch Biochem Biophys 405:1-12. 2002
    ..In sum, this review suggests that QSOX enzymes play a significant role in oxidative folding of a large variety of proteins in a wide range of multicellular organisms...
  98. ncbi The hypoblast of the chick embryo positions the primitive streak by antagonizing nodal signaling
    Federica Bertocchini
    Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, United Kingdom
    Dev Cell 3:735-44. 2002
    ..We propose that, during normal development, the primitive streak forms only when the hypoblast is displaced away from the posterior margin by the endoblast, which lacks Cerberus...
  99. ncbi ADAM 10: an active metalloprotease expressed during avian epithelial morphogenesis
    Ronelle J Hall
    Section of Molecular and Cellular Biology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Dev Biol 256:146-59. 2003
    ..When a dominant-negative metalloprotease-mutant form of ADAM 10 is expressed in the ectoderm or ADAM 10 expression is knocked down with morpholinos, morphogenesis and tissue specification are altered...
  100. ncbi Expression patterns of chicken Toll-like receptor mRNA in tissues, immune cell subsets and cell lines
    Muhammad Iqbal
    Enteric Immunology Group, G2D Stewart Building, Division of Immunology and Pathology, Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire, RG20 7NN, UK
    Vet Immunol Immunopathol 104:117-27. 2005
    ..We have determined the mRNA expression patterns for seven chicken TLRs (chTLR) in a wide range of chicken tissues, isolated immune cell types and cultured cells...
  101. pmc Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens
    Victoria J Philbin
    Division of Immunology and Pathology, Compton Laboratory, Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Immunology 114:507-21. 2005
    ..Here we report the molecular characterization of the chicken TLR7/8 loci which revealed an intact TLR7 gene and fragments of a TLR8-like gene with a 6-kilobase insertion ..

Research Grants71

  1. Eric S Johnson; Fiscal Year: 2015
    Johnson, Eric, S Certain retroviruses and herpesvirus naturally and commonly infect and cause cancer in chickens and turkeys. These viruses include some of the most potent cancer-causing agents known in animals...
  2. In-ovo vaccination/avian influenza/bird/human
    DE CHU CHRISTOPHER TANG; Fiscal Year: 2010
    ..We have demonstrated that chickens can be immunized against highly pathogenic avian influenza viruses by in ovo administration of non-replicating ..
  3. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..the vast majority of species that do not have it - non-human primates, rodents, suboscine songbirds, pigeons, chickens, etc.1,2...
  4. A novel Salmonella vaccine to protect against extra intestinal pathogenic E. coli
    Melha Mellata; Fiscal Year: 2011
    ..ExPEC strains also infect chickens causing economic losses for the poultry industry, a significant economic sector in the US and globally, due to ..
  5. Antimicrobial peptide resistance in Campylobacter jejuni
    Jun Lin; Fiscal Year: 2010
    ..jejuni colonization in chickens and are being directed toward on-farm control of this pathogen to protect public health...
  6. Fimbrial expression in Salmonella: regulation and coordination
    Steven Clegg; Fiscal Year: 2010
    ..In both hosts, humans and chickens, the pathogen colonizes and grows in the gastrointestinal (GI) tract...
  7. Rebecca Lewis; Fiscal Year: 2015
    ..Post-hatch chickens will be used to test these hypotheses in addition to organotypic cultures, gene misexpression tools, and ..
  8. PEPTIDE BASED SALMONELLA VACCINE DELIVERY SYSTEM
    Lee Riley; Fiscal Year: 1999
    ..of the project is to identify a set of protective polypeptides that can be used to prevent ovarian infection in chickens, in order to interrupt transmission of this very important human pathogen to the human population by eggs and egg ..
  9. Malaria Erythrocyte Binding-like Genes &Host Specificity in a Natural Population
    RAVINDER NATH MARIUS SEHGAL; Fiscal Year: 2011
    ..gallinaceum, a parasite of chickens. With this information, we shall isolate orthologous genes from natural populations of birds, with the intent to ..
  10. In-ovo vaccination/avian influenza/bird/human
    DE CHU TANG; Fiscal Year: 2006
    ..mobilize the immune repertoire toward a beneficial immune protection against avian influenza virus infection in chickens. In this project, efficacy of a DMA vaccine will be compared to that induced by a non-replicating Ad vector ..
  11. Mechanisms of Bottom-up and Top-down Control of Spatial Attention
    ERIC KNUDSEN; Fiscal Year: 2013
    ..We have developed automated behavioral tasks that demonstrate both kinds of control of stimulus selection in chickens. In primates, a midbrain network is essential to competitive selection...
  12. Herpesvirus-induced telomerase dysregulation and tumor formation
    Keith William Jarosinski; Fiscal Year: 2011
    ..Marek's disease virus (MDV) is a herpesvirus of chickens that causes a highly malignant T cell lymphoma...
  13. John Abramyan; Fiscal Year: 2014
    ..Mice have a complete secondary palate, chickens have a natural cleft palate and turtles have primitive palate...
  14. Hair cell development of zebrafish mutants with defects in the marginal zone
    JONATHAN MATSUI; Fiscal Year: 2010
    ..mammalian hair cells do not regenerate after damage, hair cells of non-mammalian vertebrates including fish and chickens can regenerate...
  15. Oncogenes and oncogenic microRNAs in chicken tumors
    Karen L Beemon; Fiscal Year: 2012
    ..Recently, activation of TERT by avian leukosis virus (ALV) integration was observed in B-cell lymphomas in chickens. Since the TERT integrations were clonal, this appears to be an early event in tumor development...
  16. Role of SUSD4 in Retinal Development and Function
    Feng Lin; Fiscal Year: 2010
    ..Using the refolded recombinant SUSD4 protein, we raised antibodies in chickens. We found that SUSD4 is only detectable in murine eyes, brains, spinal cords and testes, and in eyes its ..
  17. Richard L Klemke; Fiscal Year: 2016
    ..that combines high resolution confocal microscopy with unique animal models (optically transparent zebrafish and chickens) that facilitate direct visualization of cells undergoing distinct steps in the metastastic cascade in ..
  18. Robo-Slit Signaling in Avian Cornea Innervation
    Tyler Schwend; Fiscal Year: 2013
    ..organ cultures and in ovo electroporation so that the pathway may be studied in living organs and developing chickens. These studies will help to determine the overall function of the pathway on cornea innervation, in addition to ..
  19. Regulation of the v-Myb and c-Myb Oncoproteins
    Scott A Ness; Fiscal Year: 2010
    ..giving it the ability to transform hematopoietic cells in tissue culture and induce leukemias and lymphomas in chickens and mice...
  20. Xiang Jin Meng; Fiscal Year: 2016
    ..We will determine if depletion of specific CD4+ or CD8+ T cell subsets in chickens will lead to chronic infection and severe hepatitis in chickens infected with avian HEV...
  21. Monitoring nanoparticle biology in vivo: unique opportunities in the avian system
    Gisela F Erf; Fiscal Year: 2013
    ..In chickens, the ensheathed living portion of a GF is a define unit of tissue approx...
  22. Wayne K Potts; Fiscal Year: 2016
    ..For example, the virulence of Marek's disease virus of chickens has been steadily increasing over the past decades as barriers to transmission and host genetic diversity have ..
  23. DOMINANT WHITE (I) GENE OF CHICKENS: MODEL FOR VITILIGO
    ROGER BOWERS; Fiscal Year: 1991
    ..aim of this research is to test the hypothesis that the dominant white gene white gene (I) expresses itself in WL chickens by making the feather and choroid melanocytes more sensitive to a cytotoxic agent, possibly a compound produced ..
  24. JAMES KENNETH KUBILUS; Fiscal Year: 2016
    ..normal developmental innervation will be compared with reinnervation following refractive laser surgery (in adult chickens)...
  25. Role of Melanocyte Defect in Smyth Line Vitiligo
    Gisela Erf; Fiscal Year: 2001
    ..The mutant Smyth line chicken is an accepted animal model for autoimmune vitiligo. Chickens from this line develop a spontaneous, vitiligo-like, postnatal loss of melanin producing pigment cells (..
  26. Identification of factors controlling the genesis of cone photoreceptors
    Mark Emerson; Fiscal Year: 2009
    ..shows that Gnat2 and Gnb3 are both expressed specifically in the early photoreceptor layer in both mice and chickens as assayed by RNA in situ hybridizations...
  27. An expression system for protein production in eggs
    Lei Zhu; Fiscal Year: 2002
    ..expression vector for the ultimate goal of producing pharmaceutical proteins in eggs of transgenic chickens generated by embryonic stem (ES) cell-mediated transgenesis technology...
  28. AUTOIMMUNE THYROIDITIS IN A MODEL
    Roy Sundick; Fiscal Year: 1990
    ..seeks to elucidate the genetic and environmental factors which contribute to the spontaneous thyroiditis of OS chickens and the iodide-induced thyroditis of CS chickens...
  29. OPTIMIZATION OF ANTIBODY PRODUCTION IN LAYING HENS
    Rosemary Schleicher; Fiscal Year: 1991
    ..There is no booster effect in chickens, and therefore there is less animal distress from repeated handling and injections...
  30. Post Synaptic Receptors Mediating Eighth Nerve Function
    SHUNDA IRONS BROWN; Fiscal Year: 2001
    ..receptors mediating the primary afferent response to vestibular and auditory stimulation in the chicken (Gallus domesticus, ages 11 to 14 days old)...
  31. Avian Influenza Virus Vaccines Bearing Immunomodulators
    Paul Roberts; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): Avian influenza viruses pose a significant health threat for both humans and chickens in developing and developed countries...
  32. PRODUCTION OF PHARMACEUTICAL PROTEINS IN EGGS
    Marie Cecile van de Lavoir; Fiscal Year: 2000
    ..research is to establish chicken embryonic stem cell cultures with the goal of developing genetically modified chickens that produce pharmaceutical proteins in their eggs...
  33. REGULATION OF HDL SYNTHESIS AND SECRETION
    Debendranath Banerjee; Fiscal Year: 1991
    ..Our in vivo studies with chickens characterized nascent intracellular HDL particles, showed that lipid-protein assembly occurs mostly in the Golgi ..
  34. NA-K ATPASE ISOFORMS--FUNCTION AND LOCALIZATION
    Michael Tamkun; Fiscal Year: 1992
    ..that a family of genes is responsible for different isoforms of the ATPase alpha subunit in species as diverse as chickens, rodents, and man. Only one isoform of the beta subunit has been identified in any species...
  35. CONSTRUCTION OF CHICKEN X MOUSE HYBRIDOMAS
    Peter Kelleher; Fiscal Year: 1992
    ..A primary advantage in the construction of these hybridomas is the genetic differences between chickens and mammals which increases the chance of producing antibodies against highly conserved regions of mammalian ..
  36. RIBOFLAVIN BINDING PROTEIN PROMOTER
    MARILEE PARSONS; Fiscal Year: 1999
    ..Adult chickens with the disease suffer no apparent effects, suggesting the protein is required only for oogenesis...
  37. TUMOR INDUCTION BY AVIAN MYELOBLASTOSIS VIRUS
    MARCEL BALUDA; Fiscal Year: 1993
    ..AMV causes acute myeloblastic leukemia in chickens and transforms only myelomonocytic cells in vitro...
  38. PERSISTENCE OF AVIAN ARTHRITIS AGENT REOVIRUS IN VIVO
    Diana Huang; Fiscal Year: 1992
    A model for the generation of persistent infection will be established. Chickens chronically infected with avian reovirus sometimes develop an arthritis closely resembling human rheumatoid arthritis...
  39. MOLECULAR MECHANISMS OF SPECIFIC INTERCELLULAR ADHESION
    Saul Roseman; Fiscal Year: 1991
    ..e., hepatocytes from young rats and chickens, and the corresponding liver plasma membranes...
  40. EFFECT OF HERPES VIRUSES ON ARTERIAL SMOOTH MUSCLE CELLS
    JOHN TRENTIN; Fiscal Year: 1990
    ..and one transformig avian herpesvirus, Marek's disease virus (MDV), have been found to be atherogenic in chickens, even on a normal or low cholesterol diet...
  41. Gen. of transgenic chickens using a lentiviral approach
    Babette Heyer; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): [unreadable] Currently, chimeric chickens are made by injecting blastodermal cells or chicken embryonic stem cells into stage X recipient embryos, but the frequency and the level of ..
  42. Production of germline competent chicken cell lines
    Marie Cecile van de Lavoir; Fiscal Year: 2005
    ..cells that retains it potential to contribute to the germline with the goal of developing genetically modified chickens that produce pharmaceutical proteins in their eggs...
  43. TOLERANCE & IMMUNITY TO AVIAN RNA TUMOR VIRUSES & VISA
    Paul Meyers; Fiscal Year: 1980
    ..To define the relevant antigens (VEA, TSSA or others) involved in tumor recognition in chickens and to determine the relative contributions of the cellular and humoral limbs of the chicken immune system in ..
  44. Nathan A Mundell; Fiscal Year: 2014
    ..few definitive markers of early area centralis progenitors have been identified, ablation experiments in the chicken embryo suggest that positional identities of retinal progenitors are set at the optic vesicle stage, prior to ..
  45. Anil J Thachil; Fiscal Year: 2016
    ..meat diets, companion animal diets (soft/moist;dry/low moisture kibble-type products), and pet treats ("cookies", chicken jerky, beef jerky, pig ears, etc...
  46. Production of Polyclonal Antibodies in Eggs
    Marie Cecile van de Lavoir; Fiscal Year: 2003
    ..the applicant's abstract): Origen Therapeutics is committed to developing pharmaceutical products in transgenic chickens. In particular, Ongen's mission is to develop high affinity human antibodies...
  47. CELLULAR PROCESSES OF CENTRAL AUDITORY NEURONAL DEATH
    Dianne Durham; Fiscal Year: 2004
    ..Destruction of the cochlea in hatchling chickens sets in motion a series of rapid metabolic changes in postsynaptic NM neurons, including upregulation of ..
  48. Human immunotherapeutics for Biodefense Applications
    Philip Leighton; Fiscal Year: 2004
    ..Origen Therapeutics is developing transgenic chickens that will raise an antigen-specific, humoral immune response consisting of fully human polyclonal antibodies of ..
  49. GENE CONVERSION IN MYC INDUCED BURSAL LYMPHOMAS
    Craig Thompson; Fiscal Year: 2001
    ..When chickens are infected in the perinatal period with avian leukosis (ALV), a retrovirus that does not contain a known ..
  50. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2010
    ..will provide three exceptionally detailed and overlapping sets of information on the development/regeneration of chicken and mouse hair cells...
  51. REGULATION OF COCHLEAR REGENERATION BY CANONICAL WNT SIGNALING
    MATTHEW RYAN BARTON; Fiscal Year: 2012
    ..The proposed projects outlined herein describe our study of chicken inner ear sensory hair cells, which spontaneously regenerate after loss, to guide our efforts in developing ..
  52. MICHELLE LYNN STOLLER; Fiscal Year: 2014
    ..Aim 2 will involve delivery of these vectors into a chicken otocyst to observe their effects on hair cell development...
  53. The Role of RNA Interference in West Nile Virus Diversification
    Douglas E Brackney; Fiscal Year: 2010
    ..In Aim 1 we will determine if induction and/or suppression of the RNAi pathway in mosquito and chicken cells results in gains and reductions in WNV genetic diversity, respectively...
  54. Natasza A Kurpios; Fiscal Year: 2016
    ..Combined with the unique accessibility of the chicken egg, this cellular architecture has established the dorsal mesentery as a powerful model system to define, in ..
  55. Jessica Healy; Fiscal Year: 2014
    ..In California sentinel chicken flocks, mosquito infection prevalence and abundance, and the infection prevalence in dead birds are the ..
  56. Endocannabinoid-mediated long-term depression in the avian inferior colliculus
    MARIO A PENZO; Fiscal Year: 2010
    ..depression (LTD) of synaptic inputs onto neurons of the external nucleus of the inferior colliculus (EX) in chicken. This LTD is triggered by high-frequency stimulation of the afferent pathway and requires metabotropic glutamate ..
  57. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..in vitro safety testing methods, the bovine corneal opacity and permeability (BCOP) and isolated chicken eye (ICE) test methods, were accepted by U.S...
  58. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..in vitro safety testing methods, the bovine corneal opacity and permeability (BCOP) and isolated chicken eye (ICE) test methods, were accepted by U.S...
  59. Mosquito-Virus-Host Interactions and WNV Pathogenesis
    Kristen Bernard; Fiscal Year: 2007
    ..Based on preliminary data that early viremia is 100-fold higher in chickens infected with WNV by mosquitoes compared to needle inoculation, the central hypothesis is that mosquito ..
  60. Transgenic chickens for protein production
    Robert Etches; Fiscal Year: 2004
    Chimeric chickens can be produced by injecting embryonic stem (ES) cells into recipient embryos in newly laid, unincubated eggs. The embryonic stem cells contribute to all somatic tissues and sporadically to the germline...
  61. Post-translational modifications affect c-Myb specificity.
    Anita Quintana; Fiscal Year: 2009
    ..V-Myb is capable of causing acute myeloid leukemia (AMI) in chickens and can transform hematopoietic cells in vitro...
  62. Dietary Intervention in the Gallus Domesticus Model of Ovarian Cancer
    DALE HALES; Fiscal Year: 2009
    ..Aim 2) Determine if a broccoli supplemented vs. I3C supplemented diets prevent the development of ovarian cancer in chickens.
  63. SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
    Kenna D Peusner; Fiscal Year: 2010
    ..Like humans, most chickens respond to unilateral vestibular ganglionectomy by compensating rapidly, but others remain uncompensated...
  64. Regulation of insulator function and globin gene expression by USF and associated
    Suming Huang; Fiscal Year: 2013
    ..In addition, we have shown that USF mediates the boundary activity of the chicken 2-globin insulator HS4, which maintains an accessible chromatin conformation over the globin genes in erythroid ..
  65. Programming of Protective CD8 T-Cell Memory by Live and Adjuvanted Subunit Vaccin
    Marulasiddappa Suresh; Fiscal Year: 2013
    ..highly effective in controlling human infections such as smallpox, yellow fever, measles, mumps, rubella, and chicken pox...
  66. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
    ..HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  67. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
    ..HSV-1), genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  68. ANDREW BRUCE LASSAR; Fiscal Year: 2014
    ..By employing a systematic electrophoretic mobility shift assay (EMSA) with the chicken collagen X regulatory sequences, the Lassar lab has identified a DNA binding activity (termed Fast Mobility ..
  69. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda J Saif; Fiscal Year: 2010
    ..provided by applicant): We will explore oral administration of different passive heterologous antibodies (Abs), chicken egg yolk IgY and recombinant VHH fragments derived from llama heavy chain Abs as an alternative or complementary ..
  70. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2013
    ..HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...
  71. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2010
    ..HSV-1), genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV)...

Patents62

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    Patent Number: JP2016040263-A; Date:2016-03-24
  2. FGF MODULATION OF IN VIVO ANTIBODY PRODUCTION AND HUMORAL IMMUNITY
    Patent Number: JP2016520060-A; Date:2016-07-11
  3. A novel allergen and use thereof
    Patent Number: JP2016141666-A; Date:2016-08-08
  4. Novel anti-PAD4 antibody
    Patent Number: WO2016143753-A; Date:2016-09-15
  5. AVIAN CELLS FOR IMPROVED VIRUS PRODUCTION
    Patent Number: JP2016528878-A; Date:2016-09-23
  6. Extension or attraction accelerator of axon, Therapeutic agent for neurological disease or neurological injury, and scaffolding device
    Patent Number: JP2016079176-A; Date:2016-05-16
  7. METHODS OF DIFFERENTIATING STEM CELLS BY MODULATING MIR-124
    Patent Number: JP2016507218-A; Date:2016-03-10
  8. AVIAN CELLS FOR IMPROVED VIRUS PRODUCTION
    Patent Number: KR1020160012240-A; Date:2016-02-02
  9. FGF MODULATION OF IN VIVO ANTIBODY PRODUCTION AND HUMORAL IMMUNITY
    Patent Number: EP2994130-A1; Date:2016-03-16
  10. METHOD OF DETECTING AVIAN NECROTIC ENTERITIS
    Patent Number: WO2016142146-A2; Date:2016-09-15
  11. ANTI-GALECTIN-1 (GAL1) MONOCLONAL ANTIBODIES AND FRAGMENTS THEREOF FOR NEUTRALIZING GAL1
    Patent Number: EP3024496-A2; Date:2016-06-01
  12. CHEMOKINE-CYTOKINE FUSION PROTEIN AND ITS USE
    Patent Number: JP2016503434-A; Date:2016-02-04
  13. Pharmaceutical Composition for Treatment and Prevention of Cancers
    Patent Number: JP2016040290-A; Date:2016-03-24
  14. METHOD OF INDUCING AN IMMUNE RESPONSE
    Patent Number: EP3042959-A1; Date:2016-07-13
  15. CANCER TREATMENTS USING COMBINATIONS OF MEK TYPE I AND ERK INHIBITORS
    Patent Number: EP3082422-A2; Date:2016-10-26
  16. CANCER TREATMENTS USING COMBINATIONS OF CDK AND ERK INHIBITORS
    Patent Number: EP3082423-A1; Date:2016-10-26
  17. A BIGENIC MAMMALIAN EXPRESSION VECTOR
    Patent Number: WO2016151599-A1; Date:2016-09-29
  18. CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS
    Patent Number: EP3082800-A2; Date:2016-10-26
  19. POLYPEPTIDES, NUCLEIC ACIDS AND USES THEREOF
    Patent Number: EP3077413-A1; Date:2016-10-12
  20. MICRORNAS THAT REGULATE MUSCLE CELL PROLIFERATION AND DIFFERENTIATION
    Patent Number: JP2014094943-A; Date:2014-05-22
  21. Polypeptides and Methods for Diagnosis of Cancers
    Patent Number: JP2014134550-A; Date:2014-07-24
  22. Vaccine to prevent swine edema disease
    Patent Number: WO2014065210-A; Date:2014-05-01
  23. ANTI-FZD10 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE
    Patent Number: JP2014529591-A; Date:2014-11-13
  24. MAMMALIAN-TYPE GLYCOSYLATION IN PLANTS BY EXPRESSION OF NON-MAMMALIAN GLYCOSYLTRANSFERASES
    Patent Number: KR1020140059871-A; Date:2014-05-16
  25. YEAST STRAIN FOR THE PRODUCTION OF PROTEINS WITH MODIFIED O-GLYCOSYLATION
    Patent Number: EP2678440-A2; Date:2014-01-01
  26. GENERATION OF ANTI-FN14 MONOCLONAL ANTIBODIES BY EX-VIVO ACCELERATED ANTIBODY EVOLUTION
    Patent Number: EP2683740-A2; Date:2014-01-15
  27. TRANSGENIC MICROALGAE AND USE THEREOF FOR ORAL DELIVERY OF PROTEINS
    Patent Number: EP2887819-A1; Date:2015-07-01
  28. IMPROVED GENE THERAPY METHODS
    Patent Number: KR1020140064991-A; Date:2014-05-28
  29. YEAST STRAIN FOR THE PRODUCTION OF PROTEINS WITH MODIFIED O-GLYCOSYLATION
    Patent Number: KR1020140114278-A; Date:2014-09-26
  30. Method for regulating muscle cell proliferation and differentiation, treating muscle cell, controlling gene expression which are using MICRORNAS, and derepession vector of MICRORNAS molecule, Kit and Myocyt using them
    Patent Number: KR1020140130562-A; Date:2014-11-10
  31. TOLL-LIKE RECEPTORS AND IMMUNOSTIMULATORY OLIGONUCLEOTIDES
    Patent Number: KR1020150023465-A; Date:2015-03-05
  32. CANCER DETECTION METHOD
    Patent Number: KR1020150037752-A; Date:2015-04-08
  33. CANCER DETECTION METHOD
    Patent Number: KR1020150034688-A; Date:2015-04-03
  34. PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF LIVER CANCER
    Patent Number: KR1020150002617-A; Date:2015-01-07
  35. A gene expression system in mammary tissue using porcine WAP promoter
    Patent Number: KR1020150047670-A; Date:2015-05-06
  36. Method for discrimination of chicken using single nucleotide polymorphism marker in TYRP1 gene
    Patent Number: KR1020150049551-A; Date:2015-05-08
  37. Method for detecting cancer
    Patent Number: WO2014014082-A; Date:2014-01-23
  38. Discrimination method for product traceability and identification of chicken using Microsatellite DNA
    Patent Number: KR1020150056004-A; Date:2015-05-22
  39. NOVEL PROTEASES
    Patent Number: JP2015204795-A; Date:2015-11-19
  40. Glycosylation in Avians
    Patent Number: JP2014221054-A; Date:2014-11-27
  41. IMPROVED GENE THERAPY METHODS
    Patent Number: JP2014530002-A; Date:2014-11-17
  42. IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN
    Patent Number: JP2014001243-A; Date:2014-01-09
  43. A METHOD FOR PRODUCING A PIG LYSOZYME WITH THE USE OF A SECRETORY SIGNAL PEPTIDE DERIVED FROM A CHICKEN LYSOZYME
    Patent Number: JP2015065936-A; Date:2015-04-13
  44. Repressor of growth hormone expression, non-human animal of adult growth hormone deficiency model, method of preparing non-human animal of adult growth hormone deficiency model, regulator of brown adipocyte function, non-human animal of fat accumulation model and method of preparing non-human animal of fat accumulation model
    Patent Number: JP2015107950-A; Date:2015-06-11
  45. VIRAL VECTORS FOR THE TREATMENT OF RETINAL DYSTROPHY
    Patent Number: JP2015517301-A; Date:2015-06-22
  46. Prophylactic, suppressing or therapeutic agents against corneal disorder or corneal injury
    Patent Number: JP2015166323-A; Date:2015-09-24
  47. PRECAUTIONARY, PREVENTIVE, OR THERAPEUTIC SUBSTANCE FOR CORNEAL DISEASE OR CORNEAL DAMAGE, CELL SHEET, CELL CULTURE SUPPLEMENT, AND METHOD OF CULTURING CELLS
    Patent Number: WO2015133459-A; Date:2015-09-11
  48. hybrid toll-like receptor
    Patent Number: JP2015522266-A; Date:2015-08-06
  49. REENGINEERING MRNA PRIMARY STRUCTURE FOR ENHANCED PROTEIN PRODUCTION
    Patent Number: JP2015180203-A; Date:2015-10-15
  50. Vaccine to prevent Eggdrop syndrome
    Patent Number: WO2015163037-A; Date:2015-10-29
  51. METHOD, PROBE AND KIT FOR DNA IN SITU HYBRIDATION AND USE THEREOF
    Patent Number: JP2014509862-A; Date:2014-04-24
  52. Antibodys or Fragments containing variable region thereof, Antigen polypeptide, and Use thereof
    Patent Number: WO2015186721-A; Date:2015-12-10
  53. Method for genetic modification of poultry primordial germ cell, genetically modified poultry primordial germ cell, method for producing genetically modified poultry and poultry egg
    Patent Number: WO2015199225-A; Date:2015-12-30
  54. TOLL-LIKE RECEPTORS
    Patent Number: WO2014001422-A2; Date:2014-01-03
  55. EFFECTIVE AMOUNTS OF (3AR)-1,3A,8-TRIMETHYL-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2, 3-B]INDOL-5-YL PHENYLCARBAMATE AND METHODS THEREOF
    Patent Number: EP2683242-A1; Date:2014-01-15
  56. IMMUNITY INDUCING AGENT
    Patent Number: EP2711017-A1; Date:2014-03-26
  57. C1Q/TNF-RELATED PROTEIN 12 AND COMPOSITIONS AND METHODS OF USING SAME
    Patent Number: EP2696886-A2; Date:2014-02-19
  58. TRANSGENIC CHICKEN COMPRISING AN INACTIVATED IMMUNOGLOBULIN GENE
    Patent Number: EP2713712-A2; Date:2014-04-09
  59. METHOD FOR INHIBITING NON-SPECIFIC BINDING IN STEP OF DETECTING SUBSTANCE IN BIOLOGICAL SAMPLE, AND AGENT FOR USE IN THE METHOD
    Patent Number: EP2755029-A1; Date:2014-07-16
  60. PROCESSES FOR PRODUCING LIPIDS
    Patent Number: EP2798066-A1; Date:2014-11-05
  61. Interaction of Draxin and y-Netrins
    Patent Number: EP2899205-A1; Date:2015-07-29
  62. GENERATION OF ANTI-FN14 MONOCLONAL ANTIBODIES BY EX-VIVO ACCELERATED ANTIBODY EVOLUTION
    Patent Number: JP2014510079-A; Date:2014-04-24