Schistosoma mansoni

Summary

Alias:

Top Publications

  1. pmc Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection
    Fernanda C Cardoso
    Departamento de Bioquímica e Imunologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 2:e308. 2008
  2. pmc A catecholamine transporter from the human parasite Schistosoma mansoni with low affinity for psychostimulants
    Mads B Larsen
    Department of Neurobiology, University of Pittsburgh School of Medicine, PA 15260, USA
    Mol Biochem Parasitol 177:35-41. 2011
  3. ncbi Gene linkage and steady state RNAs suggest trans-splicing may be associated with a polycistronic transcript in Schistosoma mansoni
    R E Davis
    Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA
    Mol Biochem Parasitol 89:25-39. 1997
  4. pmc Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family
    Iain W Chalmers
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Genomics 9:89. 2008
  5. pmc Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover
    Mai H Tran
    Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Pathog 6:e1000840. 2010
  6. pmc Schistosoma mansoni express higher levels of multidrug resistance-associated protein 1 (SmMRP1) in juvenile worms and in response to praziquantel
    Ravi S Kasinathan
    Department of Pathobiology, University of Pennsylvania, Philadelphia, 19104, USA
    Mol Biochem Parasitol 173:25-31. 2010
  7. doi The extracellular release of Schistosoma mansoni HMGB1 nuclear protein is mediated by acetylation
    Vitor Coutinho Carneiro
    Instituto de Bioquimica Medica, Programa de Biotecnologia e Biologia Molecular, Universidade Federal do Rio de Janeiro, CCS, Ilha do Fundao, Rio de Janeiro 21941 590, Brazil
    Biochem Biophys Res Commun 390:1245-9. 2009
  8. doi Glutamate-mediated signaling in Schistosoma mansoni: a novel glutamate receptor is expressed in neurons and the female reproductive tract
    Amira Taman
    Institute of Parasitology, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Sainte Anne de Bellevue, Quebec, Canada H9X 3V9
    Mol Biochem Parasitol 176:42-50. 2011
  9. pmc The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis
    Svenja Beckmann
    Institute for Parasitology, Justus Liebig University, Giessen, Germany
    PLoS Pathog 6:e1000769. 2010
  10. doi Histamine signalling in Schistosoma mansoni: immunolocalisation and characterisation of a new histamine-responsive receptor (SmGPR-2)
    Fouad El-Shehabi
    Institute of Parasitology, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Int J Parasitol 40:1395-406. 2010

Research Grants

  1. IMMUNOLOGIC RESPONSES TO SCHISTOSOMA MANSONI
    DANIEL COLLEY; Fiscal Year: 1992
  2. ERIC SAMUEL LOKER; Fiscal Year: 2016
  3. Evo-epidemiology of Scistosoma mansoni in children in Kenya
    ERIC SAMUEL LOKER; Fiscal Year: 2010
  4. Timothy P Yoshino; Fiscal Year: 2014
  5. UNDERLYING MECHANISMS OF SCHISTOSOME/SNAIL COMPATIBILITY
    CHRISTOPHER JEFFREY BAYNE; Fiscal Year: 2012
  6. Charles Cunningham; Fiscal Year: 2014
  7. Michelle R Arkin; Fiscal Year: 2014
  8. Rodrigo Correa-Oliveira; Fiscal Year: 2016
  9. Daniel G Colley; Fiscal Year: 2014
  10. PRODUCT DEVELOPMENT OF A MEMBRANE TETRASPANIN VACCINE AGAINST SCHISTOSOMIASIS
    CHARLES RUSSELL MIDDAUGH; Fiscal Year: 2011

Patents

  1. TREATMENT OF DISEASES ASSOCIATED WITH FAT ACCUMULATION
  2. Immunomodulating agents from parasitic worms and method for isolation thereof
  3. Process for the production of lutein
  4. Process for the production of fine chemicals
  5. Process for the control of production of fine chemicals
  6. METHOD AND KIT FOR THE DETECTION OF SCHISTOSOMIASIS THROUGH POLYMERASE CHAIN REACTION
  7. GLUTATHIONE-S-TRANSFERASE SM26 OF S. MANSONI
  8. AUXOTROPHIC RECOMBINANT BCG STRAIN PASTEUR AND USE THEREOF FOR COMBATING HUMAN INFECTIONS CAUSED BY PARASITES
  9. Immune-modulating agents and uses therefor
  10. Therapeutic modulation of chemokines using a helminth parasite chemokine-binding protein

Detail Information

Publications383 found, 100 shown here

  1. pmc Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection
    Fernanda C Cardoso
    Departamento de Bioquímica e Imunologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 2:e308. 2008
    ..results have recently been obtained using membrane-spanning protein antigens from the tegument of Schistosoma mansoni. Our group recently identified Sm29, another antigen that is present at the adult worm tegument surface...
  2. pmc A catecholamine transporter from the human parasite Schistosoma mansoni with low affinity for psychostimulants
    Mads B Larsen
    Department of Neurobiology, University of Pittsburgh School of Medicine, PA 15260, USA
    Mol Biochem Parasitol 177:35-41. 2011
    The trematode Schistosoma mansoni is the primary cause of schistosomiasis, a devastating neglected tropical disease that affects 200 million individuals...
  3. ncbi Gene linkage and steady state RNAs suggest trans-splicing may be associated with a polycistronic transcript in Schistosoma mansoni
    R E Davis
    Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA
    Mol Biochem Parasitol 89:25-39. 1997
    ..and characterization of a closely linked gene upstream from the trans-spliced enolase gene in the flatworm Schistosoma mansoni. This gene produces a non-trans-spliced mRNA encoding a ubiquinol binding protein, UbCRBP, that is a ..
  4. pmc Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family
    Iain W Chalmers
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    BMC Genomics 9:89. 2008
    ..Proteins containing this domain are implicated in diverse biological activities and may be important for chronic host/parasite interactions...
  5. pmc Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover
    Mai H Tran
    Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS Pathog 6:e1000840. 2010
    ..These results imply that tetraspanins play important structural roles impacting tegument development, maturation or stability...
  6. pmc Schistosoma mansoni express higher levels of multidrug resistance-associated protein 1 (SmMRP1) in juvenile worms and in response to praziquantel
    Ravi S Kasinathan
    Department of Pathobiology, University of Pennsylvania, Philadelphia, 19104, USA
    Mol Biochem Parasitol 173:25-31. 2010
    ..Here, we examine the relationship between PZQ and SmMRP1, a Schistosoma mansoni homolog of mammalian MRP1...
  7. doi The extracellular release of Schistosoma mansoni HMGB1 nuclear protein is mediated by acetylation
    Vitor Coutinho Carneiro
    Instituto de Bioquimica Medica, Programa de Biotecnologia e Biologia Molecular, Universidade Federal do Rio de Janeiro, CCS, Ilha do Fundao, Rio de Janeiro 21941 590, Brazil
    Biochem Biophys Res Commun 390:1245-9. 2009
    b>Schistosoma mansoni HMGB1 (SmHMGB1) was revealed to be a substrate for the parasite histone acetyltransferases SmGCN5 and SmCBP1...
  8. doi Glutamate-mediated signaling in Schistosoma mansoni: a novel glutamate receptor is expressed in neurons and the female reproductive tract
    Amira Taman
    Institute of Parasitology, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Sainte Anne de Bellevue, Quebec, Canada H9X 3V9
    Mol Biochem Parasitol 176:42-50. 2011
    ..Earlier studies have shown that glutamate stimulates neuromuscular activity in the bloodfluke, Schistosoma mansoni, but its mode of action is unknown. Here we describe a novel glutamate receptor in S...
  9. pmc The Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesis
    Svenja Beckmann
    Institute for Parasitology, Justus Liebig University, Giessen, Germany
    PLoS Pathog 6:e1000769. 2010
    The signal transduction protein SmTK4 from Schistosoma mansoni belongs to the family of Syk kinases. In vertebrates, Syk kinases are known to play specialized roles in signaling pathways in cells of the hematopoietic system...
  10. doi Histamine signalling in Schistosoma mansoni: immunolocalisation and characterisation of a new histamine-responsive receptor (SmGPR-2)
    Fouad El-Shehabi
    Institute of Parasitology, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X 3V9
    Int J Parasitol 40:1395-406. 2010
    In parasitic platyhelminthes, including Schistosoma mansoni, biogenic amines play several important roles in the control of motility, metabolism and reproduction. A bioinformatics analysis of the S...
  11. pmc The tegument of the human parasitic worm Schistosoma mansoni as an excretory organ: the surface aquaporin SmAQP is a lactate transporter
    Zahra Faghiri
    Molecular Helminthology Laboratory, Division of Infectious Diseases, Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, Grafton, Massachusetts, United States of America
    PLoS ONE 5:e10451. 2010
    ..These findings extend the proposed functions of the schistosome tegument beyond its known capacity as an organ of nutrient uptake to include a role in metabolic waste excretion...
  12. pmc Structural and functional characterization of Schistosoma mansoni Thioredoxin
    Giovanna Boumis
    Dipartimento di Scienze Biochimiche and Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza University of Rome, P le Aldo Moro 5, 00185 Rome, Italy
    Protein Sci 20:1069-76. 2011
    ..of all the proteins involved in this pathway, we describe hereby the high-resolution crystal structure of Schistosoma mansoni Thioredoxin (SmTrx) in three states, namely: the wild-type oxidized adult enzyme and the oxidized and ..
  13. doi A role for p38 mitogen-activated protein kinase in early post-embryonic development of Schistosoma mansoni
    Margarida Ressurreição
    School of Life Sciences, Kingston University, Surrey, United Kingdom
    Mol Biochem Parasitol 180:51-5. 2011
    The importance of p38 mitogen-activated protein kinase (p38 MAPK) to Schistosoma mansoni miracidium to mother-sporocyst development was investigated...
  14. pmc Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni
    Vanessa Dufour
    Centre for Host Parasite Interactions, Institute of Parasitology, McGill University Macdonald Campus, Sainte Anne de Bellevue, Quebec, Canada
    PLoS Pathog 9:e1003586. 2013
    ..In this study, we characterized the anion-selective, non-acetylcholine-gated Cys-loop LGICs from Schistosoma mansoni. Full-length cDNAs were obtained for SmGluCl-1 (Smp_096480), SmGluCl-2 (Smp_015630) and SmGluCl-3 (..
  15. ncbi 14-3-3 proteins in Schistosoma mansoni; identification of a second epsilon isoform
    Sharon McGonigle
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, NY 14853, USA
    Int J Parasitol 32:685-93. 2002
    A new member of the 14-3-3 protein family in Schistosoma mansoni has been identified. Sequence analysis demonstrated that this protein is a member of the epsilon sub-group and is the orthologue of Schistosoma japonicum 14-3-3epsilon...
  16. ncbi Expression of functional Schistosoma mansoni Smad4: role in Erk-mediated transforming growth factor beta (TGF-beta) down-regulation
    Ahmed Osman
    Department of Microbiology and Immunology and Witebsky Center for Microbial Pathogenesis and Immunology, School of Medicine, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 279:6474-86. 2004
    ..b>Schistosoma mansoni receptor-regulated Smad1 and SmSmad2 were previously identified and shown to act in TGF-beta signaling...
  17. pmc Identification and characterization of a Mef2 transcriptional activator in schistosome parasites
    John N Milligan
    Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    PLoS Negl Trop Dis 6:e1443. 2012
    ..Here, we identify and characterize Mef2 from the schistosome worm Schistosoma mansoni (SmMef2)...
  18. doi Immunization with SmIg, a novel tegument protein from Schistosoma mansoni, fails to induce protection in mice but reduces liver pathology
    J M R Pinho
    Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais Minas Gerais, Belo Horizonte, MG, Brazil
    Parasitology 137:1079-88. 2010
    ..Herein, we have isolated a cDNA clone encoding for the Schistosoma mansoni SmIg and its recombinant protein was tested as a potential vaccine candidate...
  19. ncbi Isolation and characterization of Schistosoma mansoni constitutive androstane receptor
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 148:31-43. 2006
    Full length cDNA clones encoding a Schistosoma mansoni homologue of vertebrate CAR/PXR/VDR group nuclear receptor, termed SmCAR were isolated from screening a S. mansoni adult worm cDNA library...
  20. ncbi Cloning and sequence analysis of the Schistosoma mansoni membrane glycoprotein antigen gene GP22
    M El-Sherbeini
    Department of Microbiology and Molecular Genetics, Merck, Sharp and Dohme Research Laboratories, Rahway, NJ 07065
    Mol Biochem Parasitol 49:83-98. 1991
    A family of Schistosoma mansoni proteins (18-22 kDa, pI 5.3-5.8) are biosynthesized in juvenile worms and immunoprecipitated by antibodies uniquely present in protective Fischer rat antiserum...
  21. ncbi Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase
    Mohammed Sajid
    Department of Pathology, Tropical Disease Research Unit and Sandler Centre for Basic Research in Parasitic Diseases, University of California San Francisco, Box 0511, San Francisco, CA 94143, USA
    Mol Biochem Parasitol 131:65-75. 2003
    Peptidases are essential for the establishment and survival of the medically important parasite, Schistosoma mansoni. This helminth expresses a number of gut-associated peptidases that degrade host blood proteins, including hemoglobin, ..
  22. ncbi Cloning and functional expression of a Shaker-related voltage-gated potassium channel gene from Schistosoma mansoni (Trematoda: Digenea)
    E Kim
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824
    Parasitology 110:171-80. 1995
    ..1) encoding a Shaker-related K+ channel from an adult cDNA library of the human parasitic trematode Schistosoma mansoni. The deduced amino acid sequence (512 aa, 56...
  23. pmc Characterization of the methionine sulfoxide reductases of Schistosoma mansoni
    Tolulope T Oke
    Department of Biological Sciences, Illinois State University, Normal, Illinois 61790, USA
    J Parasitol 95:1421-8. 2009
    ..This is the first description of MsrB proteins from a parasite...
  24. ncbi Molecular identification of a Schistosoma mansoni tegumental protein with similarity to cytoplasmic dynein light chains
    K F Hoffmann
    Department of Pharmacology and Molecular Sciences, Center for Monoclonal Studies, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 271:26117-23. 1996
    The tegument of Schistosoma mansoni contains a number of proteins that presumably function in its maintenance and/or repair against damage incurred from host-mediated humoral immune responses...
  25. pmc Saci-1, -2, and -3 and Perere, four novel retrotransposons with high transcriptional activities from the human parasite Schistosoma mansoni
    Ricardo DeMarco
    Laboratorio de Bioinformatica Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, Brazil
    J Virol 78:2967-78. 2004
    Using the data set of 180,000 expressed sequence tags (ESTs) of the blood fluke Schistosoma mansoni generated recently by our group, we identified three novel long-terminal-repeat (LTR)- and one novel non-LTR-expressed retrotransposon, ..
  26. ncbi Cloning, characterization, and functional expression of cDNAs encoding glucose transporter proteins from the human parasite Schistosoma mansoni
    P J Skelly
    Harvard School of Public Health, Department of Tropical Public Health, Boston, Massachusetts
    J Biol Chem 269:4247-53. 1994
    The blood-dwelling adult form of the parasitic worm, Schistosoma mansoni, consumes prodigious quantities of host glucose following its transport across the tegument...
  27. pmc Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'
    Martin Horn
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS Negl Trop Dis 8:e2766. 2014
    ..Apart from the cercarial elastases, information regarding other S. mansoni serine proteases (SmSPs) is limited. To address this, we investigated SmSPs using genomic, transcriptomic, phylogenetic and functional proteomic approaches...
  28. ncbi Cloning of Schistosoma mansoni Seven in Absentia (SmSINA)(+) homologue cDNA, a gene involved in ubiquitination of SmRXR1 and SmRXR2
    Marcelo R Fantappie
    Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, School of Medicine and Biomedical Sciences, 138 Farber Hall, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 131:45-54. 2003
    ..Using the Schistosoma mansoni nuclear receptor SmRXR2 as bait in a yeast two-hybrid system, we identified a DNA fragment that encodes ..
  29. ncbi Molecular cloning and characterisation of the 22-kilodalton adult Schistosoma mansoni antigen recognised by antibodies from mice protectively vaccinated with isolated tegumental surface membranes
    S A Jeffs
    Division of Parasitology, National Institute for Medical Research, Mill Hill, London, U K
    Mol Biochem Parasitol 46:159-67. 1991
    A cDNA clone from an adult Schistosoma mansoni lambda gt11 expression library (A12) encoding an antigenic polypeptide of 22 kDa is described...
  30. ncbi Immunization with Schistosoma mansoni 22.6 kDa antigen induces partial protection against experimental infection in a recombinant protein form but not as DNA vaccine
    Lucila G G Pacifico
    Department of Biochemistry and Immunology and Institute for Investigation in Immunology Millennium Institute, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Immunobiology 211:97-104. 2006
    ..In this study we isolated a cDNA clone encoding the Schistosoma mansoni lung-stage Sm22.6 protein, which is 100% and 79% identical with the 22...
  31. ncbi Characterisation of a Rho homologue of Schistosoma mansoni
    Jon J Vermeire
    Department of Biological Sciences, Illinois State University, Normal, IL 61790 4120, USA
    Int J Parasitol 33:721-31. 2003
    The development and survival of the helminth parasite, Schistosoma mansoni, is dependent on its ability to interpret signals from its environment. Currently, little is known about signal transduction in schistosomes...
  32. ncbi SmMAK16, the Schistosoma mansoni homologue of MAK16 from yeast, targets protein transport to the nucleolus
    J L Milhon
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Biotron Building, 2115 Observatory Drive, 53705 1087, Madison, WI, USA
    Mol Biochem Parasitol 108:225-36. 2000
    The SmMAK16 gene from Schistosoma mansoni was cloned by chance when an adult worm cDNA library was probed with antiserum to affinity-purified S. mansoni GSH S-transferases...
  33. pmc The genome of the blood fluke Schistosoma mansoni
    Matthew Berriman
    Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK
    Nature 460:352-8. 2009
    b>Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke...
  34. pmc Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni
    Kathrin K Geyer
    Institute of Biological, Environmental and Rural Sciences IBERS, Aberystwyth University, Penglais Campus, Aberystwyth SY23 3DA, UK
    Nat Commun 2:424. 2011
    Similar to other metazoan pathogens, Schistosoma mansoni undergoes transcriptional and developmental regulation during its complex lifecycle and host interactions...
  35. ncbi Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni
    Ahmed A Sayed
    Department of Biological Sciences, Illinois State University, Normal, Illinois 61790 4120, USA
    J Biol Chem 279:26159-66. 2004
    ..peroxiredoxin proteins were identified in the expressed sequence tag data base of the helminth parasite Schistosoma mansoni, a causative agent of schistosomiasis...
  36. ncbi Schistosoma mansoni: comparison of cloned tropomyosin antigens shared between adult parasites and Biomphalaria glabrata
    D S Weston
    Department of Biology, Texas A and M University, College Station 77843
    Exp Parasitol 76:358-70. 1993
    ..from uninfected Biomphalaria glabrata, were used to screen a cDNA library prepared from adult Schistosoma mansoni. Of 1.8 x 10(5) recombinants screened, 34 clones were specifically immunoreactive with the antisera...
  37. ncbi The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase
    Heather M Alger
    Department of Biological Sciences, Illinois State University, Normal, IL 61790 4120, USA
    Mol Biochem Parasitol 121:129-39. 2002
    b>Schistosoma mansoni, a causative agent of schistosomiasis, is a major cause of human morbidity in tropical countries...
  38. ncbi Ferritins of Schistosoma mansoni: sequence comparison and expression in female and male worms
    J Dietzel
    Institut fur Genetik, Heinrich Heine Universitat, Dusseldorf, F R G
    Mol Biochem Parasitol 50:245-54. 1992
    Recombinant clones of Schistosoma mansoni cDNA libraries containing the complete coding regions of 2 different ferritin subunits have been isolated and sequenced...
  39. ncbi Schistosoma mansoni: identification and analysis of an mRNA and a gene encoding superoxide dismutase (Cu/Zn)
    M C Simurda
    Department of Microbiology, State University of New York, Buffalo 14214
    Exp Parasitol 67:73-84. 1988
    The sequence of an mRNA encoding superoxide dismutase (EC 1.15.1.1) of Schistosoma mansoni has been determined...
  40. ncbi Schistosoma mansoni: gene expression of the nucleotide excision repair factor 2 (NEF2) during the parasite life cycle, and in adult worms after exposure to different DNA-damaging agents
    Camila S Silva
    Department of Biochemistry and Immunology, School of Medicine, University of Sao Paulo, Av Bandeirantes 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Acta Trop 104:52-62. 2007
    ..b>Schistosoma mansoni has a complex life cycle, being exposed to a subset of DNA-damaging agents, such as those present in the ..
  41. ncbi Rapamycin insensitivity in Schistosoma mansoni is not due to FKBP12 functionality
    Alessandro Rossi
    Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Wilhelmstrasse 27, 72074 Tubingen, Germany
    Mol Biochem Parasitol 125:1-9. 2002
    ..In this study, we found the helminth parasite Schistosoma mansoni to be insensitive to the drug. In order to elucidate the mechanism underlying RAPA resistance, the S...
  42. ncbi The N-terminus moiety of the cystatin SmCys from Schistosoma mansoni regulates its inhibitory activity in vitro and in vivo
    Fabiana Carvalho Morales
    Departamento de Bioquimica Medica, ICB CCS, Universidade Federal do io de Janeiro, Ilha do Fundao, CEP 21941 590, Rio de Janeiro, Brazil
    Mol Biochem Parasitol 134:65-73. 2004
    The complete sequence of SmCys, a cystatin expressed by Schistosoma mansoni, was obtained...
  43. ncbi SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni
    Conor R Caffrey
    Tropical Disease Research Unit, Department of Pathology, Box 0511, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biochem Parasitol 121:49-61. 2002
    ..By immunohistochemistry, SmCB2 was localized in the tegumental tubercles and parenchyma of males with less product being visualized in the parenchyma of females. The enzyme may be lysosomal and function at the host parasite-interface...
  44. ncbi Characterization of Sm13, a tegumental antigen of Schistosoma mansoni
    F G Abath
    Centro de Pesquisas Aggeu Magalhaes, Fundação, Cidade Universitaria, Recife, Brazil
    Parasitol Res 86:745-52. 2000
    Sm13, a 13-kDa Schistosoma mansoni tegumental antigen, is one of the principal polypeptides recognized by antibodies from mice protectively vaccinated with adult-worm tegumental membranes...
  45. pmc The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses
    Colin M Fitzsimmons
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS Negl Trop Dis 6:e1593. 2012
    A human IgE response to Sm22.6 (a dominant IgE target in Schistosoma mansoni) is associated with the development of partial immunity...
  46. pmc A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni
    Anna V Protasio
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Negl Trop Dis 6:e1455. 2012
    ..Amongst the human-infective species, Schistosoma mansoni is also the most commonly used in the laboratory and here we present the systematic improvement of its ..
  47. ncbi Localization and pattern of expression of a female specific mRNA in Schistosoma mansoni
    M G Reis
    Escola de Medicina e Saude Publica, Salvador Bahia, Brazil
    Mol Biochem Parasitol 32:113-9. 1989
    To understand mechanisms involved in sex-specific gene expression in Schistosoma mansoni, a cDNA (fs800) was isolated that hybridized to an 800 nucleotide mRNA present in high levels only in mature female worms...
  48. ncbi A 14-kDa Schistosoma mansoni polypeptide is homologous to a gene family of fatty acid binding proteins
    D Moser
    Zentrum für Molekulare Biologie Heidelberg, University of Heidelberg, Germany
    J Biol Chem 266:8447-54. 1991
    The complete nucleotide sequence encoding a Schistosoma mansoni protein termed Sm14 was determined from cDNA clones propagated in bacteriophage lambda gt11 in Escherichia coli. The 14...
  49. pmc The role of tegumental aquaporin from the human parasitic worm, Schistosoma mansoni, in osmoregulation and drug uptake
    Zahra Faghiri
    Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, 200 Westboro Rd, North Grafton, MA 01536, USA
    FASEB J 23:2780-9. 2009
    ..These experiments reveal a heretofore unrecognized role of the schistosome tegument in controlling water and drug movement into the parasites and highlight the importance of the tegument in parasite osmoregulation and drug uptake...
  50. pmc Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host
    Cecile Perrin
    Universite de Perpignan Via Domitia, Perpignan, France
    PLoS Pathog 9:e1003571. 2013
    The digenetic trematode Schistosoma mansoni is a human parasite that uses the mollusc Biomphalaria glabrata as intermediate host. Specific S. mansoni strains can infect efficiently only certain B...
  51. ncbi Molecular characterization and immunolocalization of Schistosoma mansoni ATP-diphosphohydrolase
    Ricardo DeMarco
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Biochem Biophys Res Commun 307:831-8. 2003
    b>Schistosoma mansoni, a human parasite that constitutes a major health problem in developing countries, escapes from host defenses and survives in the human bloodstream. Here, we report the cloning of a S...
  52. ncbi Cloning the genes and DNA binding properties of High Mobility Group B1 (HMGB1) proteins from the human blood flukes Schistosoma mansoni and Schistosoma japonicum
    Francisco Meirelles Bastos de Oliveira
    Instituto de Bioquimica Medica, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Ilha do Fundao, Brazil
    Gene 377:33-45. 2006
    The parasitic helminth Schistosoma mansoni contains three HMGB proteins, HMGB1, HMGB2 and HMGB3, of primary amino acid sequences highly similar to vertebrate proteins...
  53. ncbi Schistosoma mansoni tropomyosin: cDNA characterization, sequence, expression, and gene product localization
    H Xu
    Department of Microbiology, School of Medicine, State University of New York, Buffalo 14214
    Exp Parasitol 69:373-92. 1989
    We have defined the polypeptide pattern of 3-hr Schistosoma mansoni schistosomula on nonequilibrium two-dimensional gels (NEPHGE). An acidic group of polypeptides with a molecular weight of about 40 kDa and a pI value of around 5...
  54. doi Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates
    Leonardo P Farias
    Centro de Biotecnologia, Instituto Butantan, Av Vital Brasil 1500, 05503 900 Sao Paulo, Sao Paulo, Brazil
    Parasitol Res 108:123-35. 2011
    ..attempt to identify genes up-regulated in the schistosomulum stage in relation to cercaria, we explored the Schistosoma mansoni transcriptome by looking at the relative frequency of reads in EST libraries from both stages...
  55. pmc Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a signal sequence trap method
    Danielle Smyth
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research and The University of Queensland, Brisbane, Queensland 4029, Australia
    Infect Immun 71:2548-54. 2003
    ..secreted and surface proteins with N-terminal signal peptides, so we constructed a randomly primed adult Schistosoma mansoni cDNA library fused to a signalless reporter gene encoding placental alkaline phosphatase...
  56. doi The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni
    Frédérik Oger
    INSERM, U 547, Lille, France
    Biochem Biophys Res Commun 377:1079-84. 2008
    ..To investigate the conservation of these enzymes in the platyhelminth parasite Schistosoma mansoni, we cloned and characterized three class I HDACs, orthologues of mammalian HDAC1, 3 and 8, and confirmed ..
  57. pmc Crystal structure of a Schistosoma mansoni septin reveals the phenomenon of strand slippage in septins dependent on the nature of the bound nucleotide
    Ana E Zeraik
    From the Instituto de Física de São Carlos, Universidade de Sao Paulo, 13563 120 São Carlos, Sao Paulo, Brazil
    J Biol Chem 289:7799-811. 2014
    ..Here, we present two crystal structures of the GTPase domain of a Schistosoma mansoni septin (SmSEPT10), one bound to GDP and the other to GTP...
  58. ncbi Cloning of a protein arginine methyltransferase PRMT1 homologue from Schistosoma mansoni: evidence for roles in nuclear receptor signaling and RNA metabolism
    José João Mansure
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Ilha do Fundao, Rio de Janeiro 21941 590, Brazil
    Biochem Biophys Res Commun 335:1163-72. 2005
    ..We cloned a cDNA encoding a protein arginine methyltransferase in Schistosoma mansoni (SmPRMT1). SmPRMT1 is highly homologous to the vertebrate PRMT1 enzyme...
  59. ncbi Functional conservation of Schistosoma mansoni Smads in TGF-beta signaling
    M J Beall
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Mol Biochem Parasitol 111:131-42. 2000
    To begin to understand the molecular basis of communication between the parasite Schistosoma mansoni and its mammalian host, we are studying the signaling pathway downstream of S...
  60. ncbi Structure and bioactivity of neuropeptide F from the human parasites Schistosoma mansoni and Schistosoma japonicum
    Judith E Humphries
    Department of Biomedical Sciences and Neuroscience Program, Iowa State University, Ames, Iowa 50011, USA
    J Biol Chem 279:39880-5. 2004
    The blood flukes Schistosoma mansoni and Schistosoma japonicum inflict immense suffering as agents of human schistosomiasis...
  61. pmc Schistosome I/Lamides--a new family of bioactive helminth neuropeptides
    Paul McVeigh
    School of Biological Sciences, Queen s University Belfast, Belfast, UK
    Int J Parasitol 41:905-13. 2011
    ..biological and functional characterisation of one of the peptides from the trematode parasite of humans, Schistosoma mansoni. Bioinformatics and Rapid Amplification of cDNA Ends (RACE)-PCR were used to identify the complete S...
  62. pmc Praziquantel affects the regulatory myosin light chain of Schistosoma mansoni
    Munirathinam Gnanasekar
    Department of Biomedical Sciences, College of Medicine, University of Illinois, Rockford, Illinois 61107, USA
    Antimicrob Agents Chemother 53:1054-60. 2009
    ..To begin to understand where PZQ acts, in this study we expressed the cDNA library of Schistosoma mansoni on the surface of T7 bacteriophages and screened this library with labeled PZQ...
  63. ncbi Ribosomal RNA processing and the role of SmMAK16 in ribosome biogenesis in Schistosoma mansoni
    Elizabeth E Capowski
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706 1102, USA
    Mol Biochem Parasitol 132:67-74. 2003
    ..While the physical structure and sequence of ribosomal RNA (rRNA) in the trematode Schistosoma mansoni have been described, the process of cleavage, modification and assembly of the mature ribonucleoprotein ..
  64. pmc Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity
    Jennifer M Fitzpatrick
    Department of Pathology, University of Cambridge, UK
    Int J Parasitol 39:267-79. 2009
    ..We demonstrate for the first time that several developmental stages of the human parasite Schistosoma mansoni express arginase, which is responsible for the hydrolysis of l-arginine to l-ornithine and urea...
  65. pmc The Sinbad retrotransposon from the genome of the human blood fluke, Schistosoma mansoni, and the distribution of related Pao-like elements
    Claudia S Copeland
    Department of Tropical Medicine, Tulane University Health Sciences Center, New Orleans, USA
    BMC Evol Biol 5:20. 2005
    ..It is becoming apparent that numerous LTR retrotransposons and other mobile genetic elements have colonized the genome of the human blood fluke, Schistosoma mansoni.
  66. pmc p53, Bcl-2 and C-Myc expressions in colorectal carcinoma associated with schistosomiasis in Egypt
    Khaled R Zalata
    Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    Cell Oncol 27:245-53. 2005
    ..Scarce studies were directed to colorectal cancer (CRC) associated with Schistosoma mansoni (S. mansoni). Apoptosis (programmed cell death) and the genes regulating this process (e.g...
  67. pmc Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni
    Hsin Hung Huang
    Department of Microbiology and Immunology, Rush University Medical Center, Chicago, Illinois 60612, United States
    Biochemistry 50:5870-82. 2011
    Thioredoxin glutathione reductase from Schistosoma mansoni (SmTGR) catalyzes the reduction of both thioredoxin and glutathione disulfides (GSSG), thus playing a crucial role in maintaining redox homeostasis in the parasite...
  68. ncbi Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms
    Hesham M Saeed
    Institute for Graduate Studies and Research, University of Alexandria, Chatby 21526, Alexandria, Egypt
    FEBS Lett 519:205-9. 2002
    Extracts of the adult worms of both Schistosoma mansoni and Schistosoma haematobium can metabolise some typical P450 substrates but to differing degrees. S...
  69. pmc The therapeutic effect of the neuropeptide hormone somatostatin on Schistosoma mansoni caused liver fibrosis
    Shyama Chatterjee
    Laboratory of Pathology, Faculty of Medicine, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    BMC Infect Dis 5:45. 2005
    ..has delineated an association between fibrosis and low levels of endogenous somatostatin plasma levels in Schistosoma mansoni infected subjects...
  70. ncbi Two-year follow-up of Schistosoma mansoni infection and morbidity after treatment with different regimens of oxamniquine and praziquantel
    B Gryseels
    Project Bilharziose, Coopération Belgo Burundaise, Bujumbura, Burundi
    Trans R Soc Trop Med Hyg 83:219-28. 1989
    ..5, 3, 6, 12 and 24 months after treatment for Schistosoma mansoni infection...
  71. ncbi Schistosoma mansoni excretory-secretory products stimulate a p38 signalling pathway in Biomphalaria glabrata embryonic cells
    Judith E Humphries
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Int J Parasitol 36:37-46. 2006
    Following infection with Schistosoma mansoni larvae, haemocytes of resistant Biomphalaria glabrata snails execute a rapid defence during which they migrate towards and encapsulate the parasites...
  72. ncbi Simple school questionnaires can map both Schistosoma mansoni and Schistosoma haematobium in the Democratic Republic of Congo
    C Lengeler
    Swiss Tropical Institute, Department of Public Health and Epidemiology, Basle
    Acta Trop 74:77-87. 2000
    ..For intestinal schistosomiasis due to Schistosoma mansoni there is a clear need for a similar approach...
  73. ncbi Study of the morphological characteristics of Schistosoma mansoni in mice, squirrels, and hamsters
    P C Fan
    Parasitology Laboratory, Department of Medical Research, Veterans General Hospital, VACRS, Taipei, Taiwan, Republic of China
    Southeast Asian J Trop Med Public Health 37:33-9. 2006
    ..In the present study, 6 hamsters, 35 squirrels and 141 mice were infected with pooled cercariae of Schistosoma mansoni by intraperitoneal and percutaneous routes. The worm recovery rate was 18...
  74. ncbi Control of Schistosoma mansoni in the Blue Nile Valley of western Ethiopia by mass chemotherapy and focal snail control: a primary health care experience
    S G Gundersen
    Department of Infectious Diseases, Ullevaal Hospital, University of Oslo, Norway
    Trans R Soc Trop Med Hyg 84:819-25. 1990
    ..combination of human mass treatment with oxamniquine and focal snail control has been applied in a local Schistosoma mansoni control programme in a primary health care setting in the Dalati and Agallu Metti areas of the Ethiopian ..
  75. ncbi A new focus of Schistosoma mansoni in Yoro village, Mbam and Inoubou Division, Cameroon
    Roger Moyou-Somo
    Institute of Medical Research and Study of Medicinal Plants Medical Research Center, Yaounde, Cameroon
    Am J Trop Med Hyg 69:74-7. 2003
    ..The overall prevalence of Schistosoma mansoni eggs in stool samples was 54.4% (98 of 180). The mean +/- SD intensity of infection was 100.3 +/- 114...
  76. ncbi Evidence for a dispersed Hox gene cluster in the platyhelminth parasite Schistosoma mansoni
    Raymond J Pierce
    INSERM U 547, Institut Pasteur de Lille, France
    Mol Biol Evol 22:2491-503. 2005
    ..We sought to determine whether a lophotrochozoan, the platyhelminth parasite Schistosoma mansoni, possesses a conserved or disrupted Hox cluster...
  77. doi Evaluation of immunological, parasitological and molecular methods for the diagnosis of Schistosoma mansoni infection before and after chemotherapy treatment with praziquantel in experimentally infected Nectomys squamipes
    Rosana Gentile
    Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Av Brasil 4365, CP 926, Cep 21040 360 Rio de Janeiro, RJ, Brazil
    Vet Parasitol 180:243-9. 2011
    ..In this study we evaluated three methods used in the diagnosis of Schistosoma mansoni infection: parasitological (Kato-Katz), immunological (ELISA) and molecular (real time PCR), and also ..
  78. pmc Release of leukotriene C4 (LTC4) from human eosinophils following adherence to IgE- and IgG-coated schistosomula of Schistosoma mansoni
    R Moqbel
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London
    Immunology 69:435-42. 1990
    ..C4 (LTC4) from human low-density eosinophils following adherence to live or formalin-fixed schistosomula of Schistosoma mansoni coated with parasite-specific IgE or IgG obtained from pooled human anti-S. mansoni serum has been studied...
  79. ncbi Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence
    B Gryseels
    Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 6:864-73. 2001
    This paper summarizes and concludes in-depth field investigations on suspected resistance of Schistosoma mansoni to praziquantel in northern Senegal. Praziquantel at 40 mg/kg usually cures 70-90% of S. mansoni infections...
  80. ncbi Prolonged somatostatin therapy may cause down-regulation of SSTR-like GPCRs on Schistosoma mansoni
    Shyama Chatterjee
    Pathology Laboratory, Faculty of Medicine, Antwerp University, Universiteitsplein 1, Belgium
    J Vector Borne Dis 44:164-80. 2007
    Chemotherapy with praziquantel remains the only control measure to Schistosoma mansoni infections to date...
  81. pmc Serodiagnosis of imported schistosomiasis by a combination of a commercial indirect hemagglutination test with Schistosoma mansoni adult worm antigens and an enzyme-linked immunosorbent assay with S. mansoni egg antigens
    Tom van Gool
    Department of Microbiology, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, The Netherlands
    J Clin Microbiol 40:3432-7. 2002
    A commercial indirect hemagglutination (IHA) test using erythrocytes coated with Schistosoma mansoni adult worm antigens (WA) and an enzyme-linked immunosorbent assay (ELISA) with S...
  82. pmc Integration of reporter transgenes into Schistosoma mansoni chromosomes mediated by pseudotyped murine leukemia virus
    Kristine J Kines
    Department of Tropical Medicine, and Biomedical Sciences Program, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    FASEB J 22:2936-48. 2008
    ..retrovirus (MLV) pseudotyped with vesicular stomatitis virus glycoprotein (VSVG) for the transduction of Schistosoma mansoni and delivery of reporter transgenes into schistosome chromosomes...
  83. pmc Differences in cysteine protease activity in Schistosoma mansoni-resistant and -susceptible Biomphalaria glabrata and characterization of the hepatopancreas cathepsin B Full-length cDNA
    Jocelyn Myers
    Department of Biology, Howard University, NW, Washington, DC 20059, USA
    J Parasitol 94:659-68. 2008
    Biomphalaria glabrata snails are known to display a wide range of susceptibility phenotypes to Schistosoma mansoni infection depending on the genetics of both the snail and the invading parasite...
  84. ncbi [Intestinal schistosomiasis from Schistosoma mansoni in Madagascar: extent and center of the endemic]
    G Ollivier
    OCEAC, Yaounde, Cameroun
    Bull Soc Pathol Exot 92:99-103. 1999
    b>Schistosoma mansoni and S. haematobium affect respectively 2 million and 500,000 persons in Madagascar. Over the past decade, S...
  85. ncbi The three-dimensional structure of two redox states of cyclophilin A from Schistosoma mansoni. Evidence for redox regulation of peptidyl-prolyl cis-trans isomerase activity
    Louise J Gourlay
    Istituto Pasteur Fondazione Cenci Bolognetti, Department of Biochemical Sciences A Rossi Fanelli, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
    J Biol Chem 282:24851-7. 2007
    ..cyclosporin A, which has been shown to significantly diminish worm burden in mice infected with Schistosoma mansoni. Given the well established interaction between cyclosporin A and the cyclophilin superfamily of ..
  86. ncbi Cross-reactivity of Schistosoma mansoni-Fasciola gigantica influenced by saponins
    Amany Sayed Maghraby
    Therapeutical Chemistry Department, Infectious Diseases and Immunology Group, Centre of Excellence for Advanced Sciences CEAS, the Road to Nobel Project at the National Research Centre, Dokki, 12311 Cairo, Egypt
    Z Naturforsch C 64:288-96. 2009
    The aim of the present work was to investigate the Schistosoma mansoni and Fasciola gigantica cross-reactivity between adult worms and egg homogenates of the parasites...
  87. pmc Characterization of the phytochelatin synthase of Schistosoma mansoni
    Debalina Ray
    Department of Biological Sciences, Illinois State University, Normal, Illinois, USA
    PLoS Negl Trop Dis 5:e1168. 2011
    ..In order to identify novel drug targets the Schistosoma mansoni sequence databases were queried for proteins involved in glutathione metabolism...
  88. doi Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni
    Florence Dubois
    INSERM U 547, Institut Pasteur de Lille, IFR 142, 1 rue du Professeur A Calmette, Lille, France
    Mol Biochem Parasitol 168:7-15. 2009
    In order to explore the conservation/divergence of transcriptional regulation in the platyhelminth parasite Schistosoma mansoni, we are studying the structures and functions of transcriptional mediators and in particular histone-..
  89. ncbi Phenotypic plasticity in the cercarial indices of human and rodent samples of Schistosoma mansoni (Digenea: Schistosomatidae)
    T Bogéa
    Laboratório de Parasitologia Animal, Universidade Estácio de Sá, Ciencias Biologicas, Campus CERA, Estrada da Boca do Mato 850, Vargem Pequena, Rio de Janeiro, Brazil
    Ann Trop Med Parasitol 99:583-92. 2005
    ..The CI of samples of Schistosoma mansoni of human (BH) and rodent (CMO) origin have now been compared, in an attempt to identify morphological ..
  90. ncbi Schistosoma mansoni: maturation rate and drug susceptibility of different geographic isolates
    P G Fallon
    Department of Pathology, University of Cambridge, United Kingdom
    Exp Parasitol 86:29-36. 1997
    The fecundities and drug susceptibilities of Schistosoma mansoni isolates from Senegal, Puerto Rico, and Kenya have been examined in mice...
  91. ncbi Schistosoma mansoni cationic egg antigens (CEF6): immunoserology with oxamniquine-treated patients and involvement of CEF6 in the circumoval precipitin reaction
    D W Dunne
    Department of Pathology, University of Cambridge, England
    Am J Trop Med Hyg 38:508-14. 1988
    The serologic activity of a cationic fraction (denoted CEF6) of Schistosoma mansoni soluble egg antigen was compared in an ELISA with that of the unpurified soluble egg antigen for the ability to detect human infections and for the ..
  92. pmc Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on intensity of infection and antibody responses to schistosome antigens: results of a randomised, placebo-controlled trial
    Robert Tweyongyere
    Faculty of Veterinary Medicine, Makerere University, Kampala, Uganda
    BMC Infect Dis 9:32. 2009
    ..We have therefore evaluated the effects on infection intensity and the immunological effects of praziquantel treatment against Schistosoma mansoni during pregnancy, compared with treatment after delivery.
  93. pmc Efficacy of oxamniquine and praziquantel in the treatment of Schistosoma mansoni infection: a controlled trial
    M L A Ferrari
    Department of Medical Clinics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Bull World Health Organ 81:190-6. 2003
    ..therapeutic efficacy of oxamniquine and praziquantel, the two most clinically important schistosomicide drugs, and to compare the accuracy of faecal examination with the accuracy of oogram in testing for Schistosoma mansoni infection.
  94. doi Susceptibility of Biomphalaria spp. to infection with Schistosoma mansoni in sympatric and allopatric combinations with observations on the genetic variability between snails
    Osama M S Mostafa
    Biology Department, Faculty of Science, King Khaled University, Abha 61413, PO Box 9004, Saudi Arabia
    Vet Parasitol 180:226-31. 2011
    This investigation was carried out to study the susceptibility of Saudi Biomphalaria arabica to Egyptian Schistosoma mansoni in comparison with the susceptibility of Egyptian Biomphalaria alexandrina to the same parasite...
  95. ncbi Increase of intestinal schistosomiasis after praziquantel treatment in a Schistosoma haematobium and Schistosoma mansoni mixed focus
    J C Ernould
    Centre IRD ex ORSTOM, Dakar, Senegal
    Acta Trop 73:143-52. 1999
    The recent emergence of a mixed focus of Schistosoma haematobium-Schistosoma mansoni, in the lower delta of the Senegal river, requires adapted control programmes...
  96. pmc Identification of immediate response genes dominantly expressed in juvenile resistant and susceptible Biomphalaria glabrata snails upon exposure to Schistosoma mansoni
    Wannaporn Ittiprasert
    Biomedical Research Institute, Rockville, MD 20852, USA
    Mol Biochem Parasitol 169:27-39. 2010
    Resistance or susceptibility of the snail host Biomphalaria glabrata to Schistosoma mansoni is determined by the genetics of both the snail and parasite...
  97. ncbi Immunization of mice with crude extract of Saccharomyces boulardii yeast induces cross-reactive immune responses with antigenic preparations from different developmental stages of the Schistosoma mansoni and reduces the parasite worm burden
    Mahmoud Bahgat
    Department of Medicinal Chemistry, The Central Laboratory, The National Research Center, Cairo 12311, Egypt
    J Egypt Soc Parasitol 35:563-80. 2005
    Immunization of mice with Saccharomyces boulardii crude extract caused a significant reduction in Schistosoma mansoni worm burden (23.7%; P = 0.02) in comparison to control mice...
  98. ncbi Comparative studies on the pathological findings and mortality in Schistosoma mansoni infected mice after treatment with artesunate and the current antischistosomal drugs
    Ruangyuth Chaiworaporn
    Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 36:1118-24. 2005
    The effect of artesunate (ART) on the pathology and mortality rate of in Schistosoma mansoni infected mice was comparatively studied with the current drugs of choice for the treatment of schistosomiasis mansoni: praziquantel (PZQ) and ..
  99. pmc Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthday
    R Arnon
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Protein Sci 8:2553-61. 1999
    ..biochemical and immunological investigations carried out in our laboratories on AChE of the helmint, Schistosoma mansoni. AChE appears in S...
  100. ncbi [Reinfection with Schistosoma haematobium and mansoni despite repeated praziquantel office treatment in Niger, Mali]
    A Dabo
    Service de Biologie Moléculaire de l Université d Heidelberg, Allemagne
    Med Trop (Mars) 60:351-5. 2000
    The dynamics of reinfection by Schistosoma haematobium and Schistosoma mansoni after repeated treatment with praziquantel (40 mg/kg body weight, single dose) was studied in a cohort of schoolchildren living in an endemic area...
  101. doi Biomphalaria species in Alexandria water channels
    Iman F Abou-El-Naga
    Medical Parasitology Department, Faculty of Medicine, University of Alexandria, Alexandria, Egypt
    Parasitol Int 60:247-54. 2011
    Of the several species of Biomphalaria snails worldwide that serve as the intermediate host for Schistosoma mansoni, Biomphalaria alexandrina is a species that is indigenous to Egypt...

Research Grants67

  1. IMMUNOLOGIC RESPONSES TO SCHISTOSOMA MANSONI
    DANIEL COLLEY; Fiscal Year: 1992
    ..These settings parallel schistosomiasis in the sense that in each the body's immune system must "learn" to deal with chronic antigenic exposure...
  2. ERIC SAMUEL LOKER; Fiscal Year: 2016
    ..victims of schistosomiasis live in sub-Saharan Africa, with one of the most prominent causal species being Schistosoma mansoni. This proposal focuses on the interactions between S...
  3. Evo-epidemiology of Scistosoma mansoni in children in Kenya
    ERIC SAMUEL LOKER; Fiscal Year: 2010
    ..Gerald Mkoji, as an extension of NIH application R01 AI044913 entitled "Evo-epidemiology of Schistosoma mansoni in western Kenya" for which Eric S. Loker, University of New Mexico, serves as PI...
  4. Timothy P Yoshino; Fiscal Year: 2014
    ..of inbred strains of the snail Biomphalaria glabrata to infection by larvae of the human blood fluke Schistosoma mansoni, causative agent of hepatosplenic schistosomiasis...
  5. UNDERLYING MECHANISMS OF SCHISTOSOME/SNAIL COMPATIBILITY
    CHRISTOPHER JEFFREY BAYNE; Fiscal Year: 2012
    ..glabrata snails with known susceptible or resistant phenotypes to a standard strain (Oregon PR1) of Schistosoma mansoni, a causative agent of human intestinal schistosomiasis...
  6. Charles Cunningham; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Schistosoma mansoni is one of the most common etiological agents of human schistosomiasis and is estimated to infect more than 83 million humans in 54 countries...
  7. Michelle R Arkin; Fiscal Year: 2014
    ..Secondly, we will optimize and standardize the recombinant expression of active Schistosoma mansoni HMGR, which will be central to deriving the kinetic and crystallographic data necessary to prosecute a ..
  8. Rodrigo Correa-Oliveira; Fiscal Year: 2016
    ..provided by applicant): This TMRC presents an innovative approach to understand host-parasite dynamics of Schistosoma mansoni infection in an endemic population in Brazil...
  9. Daniel G Colley; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Infection with Schistosoma mansoni remains a major public health problem in much of Africa, and it is now clear that chronic schistosome infections can lead to both severe and subtle morbidity...
  10. PRODUCT DEVELOPMENT OF A MEMBRANE TETRASPANIN VACCINE AGAINST SCHISTOSOMIASIS
    CHARLES RUSSELL MIDDAUGH; Fiscal Year: 2011
    ..From this analysis a tetrapanin surface antigen from Schistosoma mansoni and known as Sm-TSP-2 has emerged...
  11. Efficient Linkage Mapping Methods for Schistosoma mansoni
    Philip T LoVerde; Fiscal Year: 2013
    ..for Oxamniquine resistance on chr 6 providing proof-of-principal that linkage mapping is also feasible for Schistosoma mansoni. However, classical linkage mapping is extremely labor intensive, logistically challenging and expensive, ..
  12. Developing comparative and functional genomic approaches to study Schistosoma
    Phillip A Newmark; Fiscal Year: 2013
    ..in situ hybridization to compare the tissue-specific expression of 108 flatworm-specific genes in Schistosoma mansoni and S. mediterranea. We will also determine the loss-of-function phenotype for these genes in S...
  13. Understanding the biology of schistosomes in response to praziquantel
    Charles Cunningham; Fiscal Year: 2010
    ..We will exploit the fact that different life cycle stages of Schistosoma mansoni have differing susceptibilities to PZQ by employing microarrays to analyze the transcriptomes of miracidia, ..
  14. Induction of Pathogenic Innate and Adaptive Immune Responses by Schistosome Helmi
    MARA SHAINHEIT; Fiscal Year: 2009
    ..granulomatous inflammatory reaction against parasite eggs, which in the case of infection with Schistosoma mansoni, primarily takes place in the liver and intestines...
  15. SCHISTOSOME NUCLEAR PROTEIN FUNCTION AND REGULATION
    James Tracy; Fiscal Year: 2000
    ..Most cells of adult Schistosoma mansoni are quiescent. The principal exceptions are the reproductive organs, especially the female vitelline glands...
  16. MICHAEL JOHN KIMBER; Fiscal Year: 2014
    ..malayi and the parasitic flatworm Schistosoma mansoni. The first phase of the project will take place in the academic laboratories and will show that drugs ..
  17. Tim J Anderson; Fiscal Year: 2014
    ..In Schistosoma mansoni, one of three medically important schistosome species infecting humans, elegant experimental work ..
  18. Schistosoma mansoni resistance to Praziquantel treatment
    DENNIS MINCHELLA; Fiscal Year: 2007
    Schistosomiasis is caused by parasites of the Schistosoma genus, and Schistosoma mansoni is the only species found in South America. The disease causes significant human morbidity and mortality in endemic areas worldwide...
  19. PARASITIC CASTRATION IN SNAILS--ROLE OF BIOGENIC AMINES
    TIMOTHY YOSHINO; Fiscal Year: 1999
    ..However, the molecular basis for this phenomenon is still unknown. Preliminary findings show that Schistosoma mansoni infection of the snail Biomphalaria glabrata leads to a depression in oviposition and concurrently in the ..
  20. POPULATION STRUCTURE OF SCHISTOSOMES AND HOST SNAILS
    DENNIS MINCHELLA; Fiscal Year: 2003
    ..The recent characterization of microsatellite markers for Schistosoma mansoni and Biomphalaria glabrata provides an opportunity to study population structure of both host and parasite ..
  21. POPULATION STRUCTURE OF SCHISTOSOMES AND HOST SNAILS
    DENNIS MINCHELLA; Fiscal Year: 2007
    ..The recent characterization of allelic microsatellite markers for Schistosoma mansoni and Biomphalaria glabrata provides us with an opportunity to study population structure of both parasite ..
  22. DESIGN OF CHEMOTHERAPEUTIC AGENTS
    Paul Talalay; Fiscal Year: 1980
    ..specific emphasis on the development of safe and effective agents for mass treatment of infections with Schistosoma mansoni and Schistosoma japonicum...
  23. SCHISTOSOME-SNAIL COMPATIBILITY: UNDERLYING MECHANISMS
    Christopher Bayne; Fiscal Year: 1991
    ..to understand the cellular and molecular mechanisms which result in transmission of the human blood fluke Schistosoma mansoni in certain individual host snails (Biomphalaria glabrata), and the failure of transmission in others...
  24. SNAIL/SCHISTOSOME GENETIC INFLUENCES ON CERCARIOGENESIS
    Fred Lewis; Fiscal Year: 2002
    ..to identify the relevant Biomphalaria glabrata snail genes involved in resistance/susceptibility to Schistosoma mansoni, to determine their chromosomal location, and to identify developmentally regulated transcripts after ..
  25. ELECTRON MICROSCOPE
    WILLARD GRANATH; Fiscal Year: 1991
    ..b>Schistosoma mansoni, and one of its' major intermediate hosts. Biomphalaria glabrata. 2...
  26. SNAIL/SCHISTOSOME GENETIC INFLUENCES ON CERCARIOGENESIS
    Fred Lewis; Fiscal Year: 1991
    ..This research will use genetically well- characterized Biomphalaria glabrata stocks and Schistosoma mansoni strains...
  27. DEBROSKI R HERBERT; Fiscal Year: 2016
    ..b>Schistosoma mansoni is a major human pathogen affecting 108 people worldwide that causes fibrotic granulomatous inflammation in ..
  28. Kathleen C Barnes; Fiscal Year: 2016
    ..e., Schistosoma mansoni). Many genes have been associated with asthma, but to date very few have replicated...
  29. Infectious Disease Genomics and Bioinformatics Training in Brazil
    Jessica C Kissinger; Fiscal Year: 2013
    ..These organisms include: Plasmodium sp., Trypanosoma cruzi. Toxoplasma gondii, Schistosoma mansoni. Anopheles, Blomphalaria and Humans...
  30. Miguel J Stadecker; Fiscal Year: 2016
    ..This results in granulomatous and fibrosing inflammation, which in the case of the species Schistosoma mansoni, takes place in the liver and intestines...
  31. BRIAN BARKLEY GRAHAM; Fiscal Year: 2015
    ..Our overall research goal is to elucidate how the host response to Schistosoma mansoni results in PAH...
  32. Role of TGF-beta in Schistosoma mansoni
    Tori Freitas; Fiscal Year: 2009
    ..b>Schistosoma mansoni debilitates millions of people with no vaccine available and only one drug at hand for treating the disease...
  33. Development of a functional genomics toolbox for schistosome parasites
    DAVID LEE WILLIAMS; Fiscal Year: 2013
    ..Although the genome sequences of Schistosoma mansoni and S. japonicum have been determined, most predicted genes encode proteins with unknown function...
  34. The role of the vascular endothelium in schistosomiasis
    Melissa Beall; Fiscal Year: 2002
    ..Previous studies suggest that Schistosoma mansoni requires host-derived factors for normal development and sexual maturation...
  35. IDENTIFICATION OF NATURALLY PROCESSED SMANSONI PEPTIDES
    Philip Loverde; Fiscal Year: 2001
    Schistosomiasis, a debilitating disease caused by Schistosoma mansoni, is estimated to affect 200-300 million people worldwide...
  36. GEOGRAPHIC INFORMATION SYSTEMS & SCHISTOSOMIASIS
    John Malone; Fiscal Year: 2000
    ..The "Climate Based Parasite Forecast System" previously developed for Fasciola will be adapted for Schistosoma mansoni and S...
  37. Role of IL-4 During Acute Schistosomiasis
    Elisabeth Patton; Fiscal Year: 2002
    DESCRIPTION (adapted from applicant's abstract): Schistosoma mansoni is a parasitic helminth of significant public health concern. Clinical disease is due to the granulomatous response to eggs that become trapped in the liver...
  38. SEQUENCING 12 MB OF THE SCHISTOSOMA MANSONI GENOME
    Najib El Sayed; Fiscal Year: 2002
    DESCRIPTION (Investigator's Abstract): Schistosoma mansoni is a trematode parasite that causes schistosomiasis...
  39. SCHISTOSOME RECEPTOR SERINE/THRENONINE KINASE
    Edward Pearce; Fiscal Year: 1999
    The long term objective of this proposal is to elucidate the function of the Schistosoma mansoni surface membrane serine/threonine kinase...
  40. SCHISTOSOMIASIS RESEARCH REAGENT RESOURCE CENTER
    Fred A Lewis; Fiscal Year: 2009
    ..life cycles and distribute infected animals and intermediate hosts of the three human schistosome species (Schistosoma mansoni, S. haematobium, and S...
  41. SCHISTOSOMIASIS RESEARCH REAGENT RESOURCE CENTER
    Fred A Lewis; Fiscal Year: 2010
    ..life cycles and distribute infected animals and intermediate hosts of the three human schistosome species (Schistosoma mansoni, S. haematobium, and S...
  42. Effect of Schistosoma Co-infection on HIV Immune Responses
    Huyen Cao; Fiscal Year: 2007
    ..It has been proposed that chronic Schistosoma mansoni (S...
  43. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2013
    ..Mycobacterium tuberculosis and Schistosoma mansoni represent epidemic pathogens for which vaccine development has been difficult to achieve...
  44. Molecular Genetic Tools for Parasitic Helminths
    Edward J Pearce; Fiscal Year: 2013
    ..We will focus on two important human pathogens, Strongyloides stercoralis and Schistosoma mansoni. These represent, respectively, the Nematoda and Platyhelminthes, two phyla of medically important ..
  45. PNG LOKE; Fiscal Year: 2016
    Helminths such as Schistosoma mansoni are remarkably efficient at establishing chronic infections with limited inflammatory pathology in some of their hosts, while in other infected people they can cause severe morbidity and they are a ..
  46. PNG LOKE; Fiscal Year: 2014
    ..The goal of this project is to identify where these macrophages come from in order to design interventional strategies that could help regulate the inflammatory process during a type 2 response. ..
  47. Xiao Hong Sun; Fiscal Year: 2014
    ..vivo by immunizing wild type and Asb2-/- mice with a parasite antigen, the soluble egg antigen (SEA) from Schistosoma mansoni or with OVA in alum...
  48. Characterization of CCR5-like Molecules in Leishmania
    Lynn Soong; Fiscal Year: 2010
    ..cytokines/chemokines and their receptors by many pathogens, including DNA viruses, Toxoplasma gondii, and Schistosoma mansoni, such mimicry has not been identified for trypanosomatids...
  49. Stephen J Davies; Fiscal Year: 2014
    ..We recently demonstrated that Schistosoma mansoni cathepsin B1 (SmCB1), a major secreted cysteine protease of S...
  50. Natasha M Girgis; Fiscal Year: 2014
    ..We propose to use infection with the parasitic helminth Schistosoma mansoni as a model of both acute and chronic Th2 infection to examine the origins and mechanisms of differentiation ..
  51. Dynamics of SHIV clade C and S mansoni coinfection
    Ruth Ruprecht; Fiscal Year: 2005
    ..model studies have shown that vaccines that normally induce strong cellular immunity failed to do so in Schistosoma mansoni-infected animals...
  52. BIOLOGY OF TREMATODE-SNAIL ASSOCIATIONS
    ERIC SAMUEL LOKER; Fiscal Year: 2010
    ..goal of this project is to better understand the biology of snail-borne helminth parasites such as Schistosoma mansoni that continue to impose a significant burden or. 'human health in much of the developing world...
  53. PURINE METABOLISM IN SCHISTOSOMA MANSONI
    C Wang; Fiscal Year: 1991
    ..We have recently verified the absence of de novo synthesis of purine nucleotides in Schistosoma mansoni and proceeded to delineate the purine salvage pathways in this organism...
  54. TRANS-SPLICING IN PARASITIC FLATWORMS
    Richard Davis; Fiscal Year: 1992
    ..The applicant has shown that a subset of mRNAs in Schistosoma mansoni contain a 36-nucleotide spliced leader (SL) at their 5' termini...
  55. CUTANEOUS IMMUNE RESPONSE TO PARASITIC INFECTION
    Ramaswamy Kalyanasundaram; Fiscal Year: 2000
    ..this proposal is to identify the potential role of skin in initiating a protective immune response against Schistosoma mansoni infection in human and mice. The skin is the only site of entry for this parasite into human...
  56. GLYCOPROTEIN OLIGOSACCHARIDES OF SCHISTOSOMA MANSONI
    Richard Cummings; Fiscal Year: 1990
    b>Schistosoma mansoni is one of the three major parasitic blood flukes and causes a hepatosplenic disease in humans. Glycoproteins from S...
  57. GRANULOMATOUS INFLAMMATION AND INTERLEUKIN-2
    Daniel Remick; Fiscal Year: 1990
    ..will use a well-characterized model of T-cell-mediated synchronous granulomas, induced by embolization of Schistosoma mansoni eggs to the pulmonary vasculature...
  58. BIOCHEMISTRY OF SCHISTOSOME GLUTATHIONE S-TRANSFERASES
    James Tracy; Fiscal Year: 1991
    ..Adult Schistosoma mansoni contain five cytosolic glutathione S- transferases, three of which have similar properties...
  59. Immunity of Schistosome Glycoconjugates
    Richard Cummings; Fiscal Year: 2007
    Animals and humans infected with the bloodfluke Schistosoma mansoni generate specific immune responses to glycan antigens...
  60. Immune evasion by the human blood fluke Schistosoma man*
    John Hay; Fiscal Year: 2005
    ..Zvi Fishelson and Daniel Gold as an extension of NIH grant # R01AI46762. The blood fluke Schistosoma mansoni causes intestinal schistosomiasis, a parasitic disease affecting the lives of millions throughout Africa ..
  61. C-C CHEMOKINES AND EOSINOPHIL AIRWAY INFLAMMATION
    Nicholas Lukacs; Fiscal Year: 2000
    ..murine model of eosinophilic airway inflammation will be generated using an established model of Schistosoma mansoni egg antigen (SEA)-induced Th2-type hypereosinophilic response localized to the airway with airway ..
  62. BIOGENESIS OF SURFACE MEMBRANE OF SCHISTOSOMA MANSONI
    PETER WIEST; Fiscal Year: 1992
    ..Second, a research project on the biology of surface maturation of Schistosoma mansoni will be initiated under Drs. Kenneth Miller and G. Richard Olds of Brown University...
  63. GENETICS OF SEVERE HEPATIC FIBROSIS IN SCHISTOSOMIASIS
    RONALD BLANTON; Fiscal Year: 2001
    ..with portal hypertension, esophageal varices and bleeding is the most serious consequence of infection with schistosoma mansoni. The most specific indicator of this condition is hepatic fibrosis that can be accurately diagnosed by use ..
  64. SCHISTOSOME IMMUNITY MECHANISMS
    RAYMOND DAMIAN; Fiscal Year: 1980
    ..Baboons chronically infected with Schistosoma mansoni produce specific anti-worm antibodies and have lymphocytes that show depressed mitogenic and antigenic ..
  65. HTS Inhibitors:Schistosoma Mansoni Peroxiredoxins(RMI)
    David Williams; Fiscal Year: 2005
    ..b>Schistosoma mansoni peroxiredoxins (Prx) are important parasite antioxidant proteins that play a crucial role in redox balance ..
  66. Molecular Studies of Immunoparasitology in Snails
    Si Ming Zhang; Fiscal Year: 2010
    ..of the internal defenses of the snail Biomphalaria glabrata, the intermediate host of human blood fluke Schistosoma mansoni. This may lead to new methods for blocking the transmission of Schistosomiasis, a snail-borne disease that ..
  67. Developmental Gene Regulation in Schistosoma mansoni
    David Williams; Fiscal Year: 2006
    ..As genome sequencing of Schistosoma mansoni is nearly complete, functional genomic studies will be essential to capitalize on the massive genomic ..

Patents15

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    Patent Number: WO2016087612-A1; Date:2016-06-09
  2. Immunomodulating agents from parasitic worms and method for isolation thereof
    Patent Number: WO02085930-A2; Date:2002-10-31
  3. Process for the production of lutein
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  4. Process for the production of fine chemicals
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  5. Process for the control of production of fine chemicals
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  6. METHOD AND KIT FOR THE DETECTION OF SCHISTOSOMIASIS THROUGH POLYMERASE CHAIN REACTION
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  7. GLUTATHIONE-S-TRANSFERASE SM26 OF S. MANSONI
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  8. AUXOTROPHIC RECOMBINANT BCG STRAIN PASTEUR AND USE THEREOF FOR COMBATING HUMAN INFECTIONS CAUSED BY PARASITES
    Patent Number: JP2012519496-A; Date:2012-08-30
  9. Immune-modulating agents and uses therefor
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  10. Therapeutic modulation of chemokines using a helminth parasite chemokine-binding protein
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  11. Process for the production of fine chemicals
    Patent Number: WO2005014828-A2; Date:2005-02-17
  12. AUXOTROPHIC, RECOMBINANT BCG STRAIN PASTEUR AND USE THEREOF FOR COMBATING HUMAN INFECTIONS CAUSED BY PARASITES
    Patent Number: EP2407545-A1; Date:2012-01-18
  13. Treatment of helminth infection by inhibition of tyrosinase
    Patent Number: WO2006037958-A2; Date:2006-04-13
  14. Immunomodulating agents from parasitic worms and method for isolation thereof
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    Patent Number: WO0151512-A2; Date:2001-07-19