Streptomyces venezuelae

Summary

Alias: Streptomyces venezuelensis, Streptomyces venezuelae Ehrlich et al. 1948

Top Publications

  1. ncbi Site-specific integration of bacteriophage VWB genome into Streptomyces venezuelae and construction of a VWB-based integrative vector
    L Van Mellaert
    Laboratory of Bacteriology, Rega Instituut, KU Leuven, Belgium
    Microbiology 144:3351-8. 1998
  2. ncbi The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase
    Brian J Beck
    Department of Microbiology and Biotechnology Institute, University of Minnesota, Mayo Mail Code 196, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    Chem Biol 9:575-83. 2002
  3. ncbi Bioconversion of 12-, 14-, and 16-membered ring aglycones to glycosylated macrolides in an engineered strain of Streptomyces venezuelae
    Won Seok Jung
    Interdisciplinary Program of Biochemical Engineering and Biotechnology, Seoul National University, San 56 1, Shilim Dong, Gwanak Gu, Seoul 151 742, South Korea
    Appl Microbiol Biotechnol 76:1373-81. 2007
  4. ncbi Modular architecture of the conjugative plasmid pSVH1 from Streptomyces venezuelae
    Jens Reuther
    Microbiology Biotechnology, Microbiological Institute, Faculty of Biology, University of Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Plasmid 55:201-9. 2006
  5. doi Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis
    E Sethe Burgie
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biochemistry 47:3982-8. 2008
  6. pmc Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine
    E Sethe Burgie
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biochemistry 46:8999-9006. 2007
  7. ncbi Genetically engineered biosynthesis of macrolide derivatives including 4-amino-4,6-dideoxy-L-glucose from Streptomyces venezuelae YJ003-OTBP3
    Binod Babu Pageni
    Institute of Biomolecule Reconstruction iBR, Department of Pharmaceutical Engineering, SunMoon University, Asan 336 708, Korea
    J Microbiol Biotechnol 18:88-94. 2008
  8. ncbi Heterologous production and detection of recombinant directing 2-deoxystreptamine (DOS) in the non-aminoglycoside-producing host Streptomyces venezuelae YJ003
    Nagendra Prasad Kurumbang
    Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, Asan 336 708, Korea
    J Microbiol Biotechnol 18:866-73. 2008
  9. doi Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides
    Sushila Maharjan
    Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, Tangjeonmyun, Asansi, Chungnam 336 708, Republic of Korea
    Biotechnol Lett 32:277-82. 2010
  10. ncbi Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230
    L Han
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Microbiology 140:3379-89. 1994

Research Grants

  1. Seth A Darst; Fiscal Year: 2015
  2. Janet L Smith; Fiscal Year: 2016
  3. BIOSYNTHESIS OF AROMATIC POLYKETIDES
    CHARLES SIH; Fiscal Year: 2001
  4. GENERATION OF KETOLIDES BY COMBINATORIAL BIOSYNTHESIS
    Yongquan Xue; Fiscal Year: 1999
  5. GLYCOSYLATION OF POLYKETIDES BY A GLYCOSYLTRANSFERASE
    PAUL SHELDON; Fiscal Year: 2000
  6. Improving Glycosyltransferase by RACHITT Gene Shuffling
    Yongquan Xue; Fiscal Year: 2001
  7. COMBINATORIAL BIOSYNTHESIS AND THE PIKROMYCIN PATHWAY
    David Sherman; Fiscal Year: 2002
  8. BIOCHEMISTRY AND MOLECULAR GENETICS OF MITOMYCIN BIOSYNT
    David Sherman; Fiscal Year: 2003
  9. Genomic Analysis of Antibiotic Biosynthesis
    David Sherman; Fiscal Year: 2005

Patents

  1. EXPRESSION CASSETTES AND THEIR USE
  2. DNA encoding methymycin and pikromycin
  3. Recombinant narbonolide polyketide synthase
  4. Process for the production of lutein
  5. Process for the production of fine chemicals
  6. Process for the control of production of fine chemicals
  7. In Vivo Incorporation of Unnatural Amino Acids
  8. Identifying lantibiotic gene clusters and novel lantibiotic genes
  9. Method to alter sugar moieties
  10. In Vivo Incorporation of Unnatural Amino Acids

Scientific Experts

  • David L Jakeman
  • Matthew Bush
  • Susan Schlimpert
  • Jaap C Hanekamp
  • Jeroen S Dickschat
  • Gang Liu
  • Mark W Ruszczycky
  • Maureen J Bibb
  • Feng Gao
  • T Izard
  • Yeo Joon Yoon
  • David Sherman
  • S Pospisil
  • Bin Hong
  • E Lammertyn
  • Koji Yanai
  • Je Won Park
  • Sung Ryeol Park
  • Jae Kyung Sohng
  • Ah Reum Han
  • Yongquan Xue
  • Eun Ji Kim
  • Young Ji Yoo
  • Yeon Hee Ban
  • Won Seok Jung
  • Janet L Smith
  • Keqian Yang
  • Sushila Maharjan
  • Eunji Kim
  • Tae Jin Oh
  • Juan Wang
  • E Sethe Burgie
  • PAUL SHELDON
  • CHARLES SIH
  • Seth A Darst
  • Kwangkyoung Liou
  • Hei Chan Lee
  • Balakrishnan Naveena
  • Keqiang Fan
  • Huarong Tan
  • Linqi Wang
  • Nagendra Prasad Kurumbang
  • Joseph A Chemler
  • Binod Babu Pageni
  • Jay Sung Joong Hong
  • Weishan Wang
  • Leo C Vining
  • Svetlana A Borisova
  • Pramod B Shinde
  • Cha Yong Choi
  • Byung Gee Kim
  • Gangming Xu
  • Kateryna Podzelinska
  • Ryan Latimer
  • Walter E Kowtoniuk
  • Jeffrey D Kittendorf
  • Ryan M Phelan
  • Hung wen Liu
  • Lieve Van Mellaert
  • Jozef Anne
  • Patrick Rabe
  • Xiaoxue Zhou
  • Olga N Sekurova
  • Anna L Watkins
  • Ju Yeon Song
  • Anyarat Thanapipatsiri
  • Hazel M Holden
  • Jingxuan He
  • Amit Kumar Jha
  • Devi B Basnet
  • Gopal Prasad Ghimire
  • Andrew W Robertson
  • L C Vining
  • Jens Reuther
  • Douglas A Hansen
  • Nguyen Lan Huong
  • Jonathan R Whicher
  • A Ray
  • Justin R Nodwell
  • Govind Chandra
  • N H Hoang
  • Thangamani Rajesh
  • Jinwei Ren
  • Julio C Ayala
  • Margaret C M Smith
  • Steven J Malcolmson
  • Yuanyuan Pan
  • Raymond T Syvitski
  • Marta Santos
  • Bjorn Berendsen

Detail Information

Publications128 found, 100 shown here

  1. ncbi Site-specific integration of bacteriophage VWB genome into Streptomyces venezuelae and construction of a VWB-based integrative vector
    L Van Mellaert
    Laboratory of Bacteriology, Rega Instituut, KU Leuven, Belgium
    Microbiology 144:3351-8. 1998
    The temperate bacteriophage VWB integrates into the chromosome of Streptomyces venezuelae ETH14630 via site-specific integration...
  2. ncbi The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase
    Brian J Beck
    Department of Microbiology and Biotechnology Institute, University of Minnesota, Mayo Mail Code 196, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    Chem Biol 9:575-83. 2002
    The pikromycin (Pik) polyketide synthase (PKS) from Streptomyces venezuelae comprises four multifunctional polypeptides (PikAI, PikAII, PikAIII, and PikAIV)...
  3. ncbi Bioconversion of 12-, 14-, and 16-membered ring aglycones to glycosylated macrolides in an engineered strain of Streptomyces venezuelae
    Won Seok Jung
    Interdisciplinary Program of Biochemical Engineering and Biotechnology, Seoul National University, San 56 1, Shilim Dong, Gwanak Gu, Seoul 151 742, South Korea
    Appl Microbiol Biotechnol 76:1373-81. 2007
    To develop a system for combinatorial biosynthesis of glycosylated macrolides, Streptomyces venezuelae was genetically manipulated to be deficient in the production of its macrolide antibiotics by deletion of the entire biosynthetic gene ..
  4. ncbi Modular architecture of the conjugative plasmid pSVH1 from Streptomyces venezuelae
    Jens Reuther
    Microbiology Biotechnology, Microbiological Institute, Faculty of Biology, University of Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Plasmid 55:201-9. 2006
    The conjugative rolling circle replication (RCR) type plasmid pSVH1 from the chloramphenicol producer Streptomyces venezuelae was characterized by DNA sequence analysis and insertion/deletion analysis...
  5. doi Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis
    E Sethe Burgie
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biochemistry 47:3982-8. 2008
    ..Six enzymes are required for the biosynthesis of dTDP-desosamine in Streptomyces venezuelae, with the last step catalyzed by DesVI, an N, N-dimethyltransferase...
  6. pmc Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine
    E Sethe Burgie
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biochemistry 46:8999-9006. 2007
    ..In the bacterium Streptomyces venezuelae, six enzymes are required for the production of dTDP-desosamine...
  7. ncbi Genetically engineered biosynthesis of macrolide derivatives including 4-amino-4,6-dideoxy-L-glucose from Streptomyces venezuelae YJ003-OTBP3
    Binod Babu Pageni
    Institute of Biomolecule Reconstruction iBR, Department of Pharmaceutical Engineering, SunMoon University, Asan 336 708, Korea
    J Microbiol Biotechnol 18:88-94. 2008
    ..These results suggest a successful engineering of a deoxysugar pathway to generate novel hybrid macrolide derivatives, including deoxyaminosugar...
  8. ncbi Heterologous production and detection of recombinant directing 2-deoxystreptamine (DOS) in the non-aminoglycoside-producing host Streptomyces venezuelae YJ003
    Nagendra Prasad Kurumbang
    Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, Asan 336 708, Korea
    J Microbiol Biotechnol 18:866-73. 2008
    ..The recombinant pNDOS was transformed into a non-aminoglycoside-producing host, Streptomyces venezuelae YJ003, for heterologous expression...
  9. doi Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides
    Sushila Maharjan
    Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, Tangjeonmyun, Asansi, Chungnam 336 708, Republic of Korea
    Biotechnol Lett 32:277-82. 2010
    Using metabolic engineering, we developed Streptomyces venezuelae YJ028 as an efficient heterologous host to increase the malonyl-CoA pool to be directed towards enhanced production of various polyketides...
  10. ncbi Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230
    L Han
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Microbiology 140:3379-89. 1994
    Hybridizing fragments in the genomic DNA of Streptomyces venezuelae ISP5230, which produces the jadomycin group of angucycline antibiotics, were detected by probing with actI DNA from Streptomyces coelicolor A3(2)...
  11. ncbi Regulation of an anthranilate synthase gene in Streptomyces venezuelae by a trp attenuator
    C Lin
    Biology Department, Dalhousie University, Halifax, NS, Canada
    Microbiology 144:1971-80. 1998
    The nucleotide sequence of a 2-4 kb BamHI-SalI fragment of Streptomyces venezuelae ISP5230 DNA that complements trpE and trpG mutations in Escherichia coli contains two ORFs...
  12. ncbi Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin
    Beom Seok Kim
    Department of Medicinal Chemistry and Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond 23219, USA
    J Biol Chem 277:48028-34. 2002
    ..The lack of rigorous substrate specificity for TEII may explain the surprising observation that high level expression of the protein in Streptomyces venezuelae leads to significant (>50%) titer decreases.
  13. ncbi Biosynthesis of the dichloroacetyl component of chloramphenicol in Streptomyces venezuelae ISP5230: genes required for halogenation
    Mahmood Piraee
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Microbiology 150:85-94. 2004
    Five ORFs were detected in a fragment from the Streptomyces venezuelae ISP5230 genomic DNA library by hybridization with a PCR product amplified from primers representing a consensus of known halogenase sequences...
  14. ncbi Characterization and identification of chitinase producing Streptomyces venezuelae P10
    G Mukherjee
    Microbiology Laboratory, School of Life Sciences, Department of Botany, Visva Bharati, Santiniketan 731 235, India
    Indian J Exp Biol 42:541-4. 2004
    ..Chitinase assay showed that the isolate could produce 0.8 U/ml of the enzyme. The morphological, cultural, physiological and biochemical characters of the isolate P10 were studied, and identified as Streptomyces venezuelae P10.
  15. ncbi The role of erythromycin C-12 hydroxylase, EryK, as a substitute for PikC hydroxylase in pikromycin biosynthesis
    Sang Kil Lee
    School of Chemical Engineering, College of Engineering, Seoul National University, San 56 1, Sinlim Dong, Gwanak gu 151 742, Republic of Korea
    Bioorg Chem 32:549-59. 2004
    ..We have shown that EryK can accept the substrates of PikC from Streptomyces venezuelae which is responsible for the hydroxylation of YC-17 and narbomycin. In a S...
  16. ncbi Complete genomic nucleotide sequence and analysis of the temperate bacteriophage VWB
    W Van Dessel
    Laboratorium voor Bacteriologie, Katholieke Universiteit Leuven, Rega Instituut, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Virology 331:325-37. 2005
    The entire double-stranded DNA genome of the Streptomyces venezuelae bacteriophage VWB was sequenced and analyzed. Its size is 49,220 bp with an overall molar G + C content of 71.2 mol%...
  17. ncbi Functional large-scale production of a novel Jonesia sp. xyloglucanase by heterologous secretion from Streptomyces lividans
    Giorgos Sianidis
    Institute of Molecular Biology and Biotechnology FORTH and Department of Biology, University of Crete, P O Box 1527, Iraklio Crete 71110, Greece
    J Biotechnol 121:498-507. 2006
    ..Xeg was fused C-terminally to the secretory signal peptide of the subtilisin inhibitor protein (vsi) from Streptomyces venezuelae. The native Xeg signal peptide derived from Jonesia sp. is only poorly functional in S. lividans...
  18. pmc Expression, purification and preliminary diffraction studies of CmlS
    Ryan Latimer
    Department of Chemistry, Queen s University, Kingston, Ontario, Canada
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:260-3. 2009
    CmlS, a flavin-dependent halogenase (FDH) present in the chloramphenicol-biosynthetic pathway in Streptomyces venezuelae, directs the dichlorination of an acetyl group...
  19. doi Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77
    Jinwei Ren
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People s Republic of China
    Bioorg Med Chem Lett 23:301-4. 2013
    ..D and carboxyexfoliazone were isolated from the fermentation broth of the marine-derived bacterium Streptomyces venezuelae. The structures of new compounds were determined on the basis of extensive spectroscopic analysis...
  20. pmc EPR-kinetic isotope effect study of the mechanism of radical-mediated dehydrogenation of an alcohol by the radical SAM enzyme DesII
    Mark W Ruszczycky
    Division of Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 110:2088-93. 2013
    The radical S-adenosyl-L-methionine enzyme DesII from Streptomyces venezuelae is able to oxidize the C3 hydroxyl group of TDP-D-quinovose to the corresponding ketone via an α-hydroxyalkyl radical intermediate...
  21. doi Occurrence of chloramphenicol in crops through natural production by bacteria in soil
    Bjorn Berendsen
    RIKILT, Wageningen UR, P O Box 230, 6700AE, Wageningen, The Netherlands
    J Agric Food Chem 61:4004-10. 2013
    ..Second, the production of chloramphenicol in soil was studied, and it was confirmed that Streptomyces venezuelae can produce chloramphenicol at appreciable amounts in nonsterile soil...
  22. doi Phosphorylation of chloramphenicol by a recombinant protein Yhr2 from Streptomyces avermitilis MA4680
    Thangamani Rajesh
    Department of Microbial Engineering, College of Engineering, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, South Korea
    Bioorg Med Chem Lett 23:3614-9. 2013
    Although phosphorylation of chloramphenicol has been shown to occur in the chloramphenicol producer, Streptomyces venezuelae, there are no reports on the existence of chloramphenicol phosphorylase in other Streptomyces species...
  23. doi Regio-selectively reduced streptogramin A analogue, 5,6-dihydrovirginiamycin M1 exhibits improved potency against MRSA
    N H Hoang
    Department of Pharmaceutical Engineering, SunMoon University, Asan, Korea
    Lett Appl Microbiol 57:393-8. 2013
    ..A, 5,6-dihydrovirginiamycin M1 was created by feeding virginiamycin M1 into a culture of recombinant Streptomyces venezuelae. Its chemical structure was spectroscopically elucidated, and this streptogramin A analogue showed ..
  24. ncbi Biotransformation of rosamicin antibiotic into 10,11-dihydrorosamicin with enhanced in vitro antibacterial activity against MRSA
    Nguyen Lan Huong
    Department of Pharmaceutical Engineering, SunMoon University, Asan 336 708, Republic of Korea
    J Microbiol Biotechnol 24:44-7. 2014
    ..By employing a recombinant Streptomyces venezuelae strain as a microbial catalyst, a reduced macrolide, 10,11-dihydrorosamicin, was created from rosamicin ..
  25. pmc Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model
    A Ray
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL, USA
    Cell Death Dis 5:e984. 2014
    ..Previously, we reported that a bacterial metabolite produced by Streptomyces venezuelae caused age- and dose-dependent DA neurodegeneration in Caenorhabditis elegans and human SH-SY5Y neurons...
  26. pmc Angucyclines as signals modulate the behaviors of Streptomyces coelicolor
    Weishan Wang
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Proc Natl Acad Sci U S A 111:5688-93. 2014
    The angucycline antibiotic jadomycin B (JdB) produced by Streptomyces venezuelae has been found here to induce complex survival responses in Streptomyces coelicolor at subinhibitory concentration...
  27. pmc Structural rearrangements of a polyketide synthase module during its catalytic cycle
    Jonathan R Whicher
    1 Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA 2 Chemical Biology Graduate Program, University of Michigan, Ann Arbor, Michigan 48109, USA 3
    Nature 510:560-4. 2014
    ..The architecture of a full-length PKS module from the pikromycin pathway of Streptomyces venezuelae creates a reaction chamber for the intramodule acyl carrier protein (ACP) domain that carries building ..
  28. doi Are you talking to me? A possible role for γ-butyrolactones in interspecies signalling
    Justin R Nodwell
    Department of Biochemistry, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada, M5S 1A8
    Mol Microbiol 94:483-5. 2014
    The secreted γ-butyrolactone signalling molecule SVB1 regulates the biosynthesis of jadomycin in Streptomyces venezuelae. Interestingly, this molecule is identical to SCB3, a secreted regulator of secondary metabolism in Streptomyces ..
  29. ncbi Activation of Cryptic hop Genes from Streptomyces peucetius ATCC 27952 Involved in Hopanoid Biosynthesis
    Gopal Prasad Ghimire
    Institute of Biomolecule Reconstruction iBR, Department of BT Convergent Pharmaceutical Engineering, Sun Moon University, Asansi 336 708, Republic of Korea
    J Microbiol Biotechnol 25:658-61. 2015
    ..cloned from the hopanoid (hop) gene cluster of Streptomyces peucetius ATCC 27952 and transformed into Streptomyces venezuelae YJ028. The cloned fragments contained four genes, all transcribed in one direction...
  30. doi Antibiotics exposure and health risks: chloramphenicol
    Jaap C Hanekamp
    Science Department, University College Roosevelt, P O Box 94, 4330 AB Middelburg, the Netherlands Environmental Health Sciences, University of Massachusetts, Amherst, USA Chair Working Group Chemical Food Safety of the Global Harmonization Initiative GHI Electronic address
    Environ Toxicol Pharmacol 39:213-20. 2015
    ..Besides being a medicinal product, CAP is also a natural product, produced by Streptomyces Venezuelae. The lack of scientific data hampers setting of an Acceptable Daily Intake (ADI)...
  31. doi Structural modification of herboxidiene by substrate-flexible cytochrome P450 and glycosyltransferase
    Amit Kumar Jha
    Institute of Biomolecule Reconstruction iBR, Department of BT Convergent Pharmaceutical Engineering, Sun Moon University, 70, Sunmoon Ro221, Tangjeong myeon, Asan, Chungnam, 333 708, Republic of Korea
    Appl Microbiol Biotechnol 99:3421-31. 2015
    ..chromofuscus PikC harboring pikC from the pikromycin gene cluster of Streptomyces venezuelae and S. chromofuscus EryF harboring eryF from the erythromycin gene cluster of Saccharopolyspora erythraea...
  32. doi Characterization of l-Digitoxosyl-phenanthroviridin from Streptomyces venezuelae ISP5230
    Andrew W Robertson
    Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 4R2
    J Nat Prod 78:1942-8. 2015
    The jadomycin-derived compound l-digitoxosyl-phenanthroviridin was isolated from fermentations of Streptomyces venezuelae ISP5230 grown in nutrient-deficient media with l-lysine as the sole nitrogen source...
  33. pmc Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination
    Joseph A Chemler
    Sequoia Sciences, Inc, 1912 Innerbelt Business Center Drive, Saint Louis, Missouri 63114, United States
    J Am Chem Soc 137:10603-9. 2015
    ..Active chimeric enzymes were identified with new functionality. Streptomyces venezuelae strains that expressed these PKS chimeras were capable of producing engineered macrolactones...
  34. doi Complete genome sequence of Streptomyces venezuelae ATCC 15439, a promising cell factory for production of secondary metabolites
    Ju Yeon Song
    Department of Systems Biology and Division of Life Sciences, Yonsei University, 50 Yonsei ro, Seodaemun gu, Seoul 03722, Republic of Korea
    J Biotechnol 219:57-8. 2016
    b>Streptomyces venezuelae ATCC 15439, which produces 12- and 14-membered ring macrolide antibiotics, is a platform strain for heterologous expression of secondary metabolites. Its 9...
  35. pmc The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp
    Anna L Watkins
    Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama
    Sci Rep 6:22566. 2016
    Recent work from our labs demonstrated that a metabolite(s) from the soil bacterium Streptomyces venezuelae caused dopaminergic neurodegeneration in Caenorhabditis elegans and human neuroblastoma cells...
  36. pmc Complete Genome Sequence of Streptomyces venezuelae ATCC 15439, Producer of the Methymycin/Pikromycin Family of Macrolide Antibiotics, Using PacBio Technology
    Jingxuan He
    Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico, USA
    Genome Announc 4:. 2016
    Here, we report the complete genome sequence of Streptomyces venezuelae ATCC 15439, a producer of the methymycin/pikromycin family of macrolide antibiotics and a model host for natural product studies, obtained exclusively using PacBio ..
  37. pmc Activation of chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712 by ethanol shock: insights from the promoter fusion studies
    Olga N Sekurova
    Department of Pharmacognosy, University of Vienna, 1090, Vienna, Austria
    Microb Cell Fact 15:85. 2016
    b>Streptomyces venezuelae ATCC 10712 produces antibiotics chloramphenicol (Cml) and jadomycin (Jad) in response to nutrient limitation and ethanol shock (ES), respectively...
  38. pmc The EIMS fragmentation mechanisms of the sesquiterpenes corvol ethers A and B, epi-cubebol and isodauc-8-en-11-ol
    Patrick Rabe
    Kekule Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard Domagk Straße 1, 53121 Bonn, Germany
    Beilstein J Org Chem 12:1380-94. 2016
    ..setae, the epi-cubebol synthase from Streptosporangium roseum, and the isodauc-8-en-11-ol synthase from Streptomyces venezuelae. The enzyme products were analysed by GC-MS and GC-QTOF MS(2) and the obtained data were used to ..
  39. pmc Fast Mechanically Driven Daughter Cell Separation Is Widespread in Actinobacteria
    Xiaoxue Zhou
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA
    MBio 7:. 2016
    ..Most intriguingly, similar fast mechanical DCS was also observed during the sporulation of the actinobacterium Streptomyces venezuelae
  40. pmc Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster
    Anyarat Thanapipatsiri
    Department of Genetics, Faculty of Science, Kasetsart University, 50 Ngamwongwan Road, Ladyao, Chatuchak, Bangkok, 10900, Thailand
    Chembiochem 17:2189-2198. 2016
    Comparative transcriptional profiling of a ΔbldM mutant of Streptomyces venezuelae with its unmodified progenitor revealed that the expression of a cryptic biosynthetic gene cluster containing both type I and type III polyketide ..
  41. doi Development of Next Generation Synthetic Biology Tools for Use in Streptomyces venezuelae
    Ryan M Phelan
    Joint BioEnergy Institute, 5885 Hollis Street, Emeryville, California 94608, United States
    ACS Synth Biol 6:159-166. 2017
    ..In an effort to improve genetic tools for Streptomyces venezuelae, we developed a suite of standardized, orthogonal integration vectors and an improved method to monitor ..
  42. ncbi Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae
    Yeo Joon Yoon
    Department of Microbiology and Biotechnology Institute, University of Minnesota, Mayo Mail Code 196, 1460 Mayo Memorial Building, Minneapolis, MN 55455, USA
    Chem Biol 9:203-14. 2002
    ..This work demonstrates the unique capacity of the S. venezuelae pikromycin pathway to expand the toolbox of combinatorial biosynthesis and to accelerate the creation of novel biologically active natural products...
  43. ncbi The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis
    Uwe Rix
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 907 Rose Street, Lexington, Kentucky 40536 0082, USA
    J Am Chem Soc 126:4496-7. 2004
    ..with a unique 8H-benz[b]oxazolo[3,2-f]phenanthridine pentacyclic skeleton produced by the bacterium Streptomyces venezuelae ISP 5230, exists in a dynamic equilibrium of two diastereomers differing in the configuration of C-3a...
  44. ncbi Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics
    Svetlana A Borisova
    Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712, USA
    J Am Chem Soc 126:6534-5. 2004
    ..involved in the biosynthesis of methymycin, neomethymycin, narbomycin, and pikromycin in Streptomyces venezuelae, is described...
  45. ncbi Comparison of the Sec and Tat secretion pathways for heterologous protein production by Streptomyces lividans
    Kristien Schaerlaekens
    Laboratory of Bacteriology, Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Biotechnol 112:279-88. 2004
    ..lower for Tat-dependent than for Sec-dependent transport using the Sec-dependent signal peptide of the Streptomyces venezuelae subtilisin inhibitor. Surprisingly, Sec-dependent transport was enhanced in the tatB deletion strain...
  46. ncbi Bacterial P450-catalyzed polyketide hydroxylation on a microfluidic platform
    Aravind Srinivasan
    Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Biotechnol Bioeng 88:528-35. 2004
    ..The PikC hydroxylase Streptomyces venezuelae was incorporated into a PDMS-based microfluidic channel...
  47. pmc Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase
    Yi Hua Chen
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences and Graduate School of Chinese Academy of Sciences, Beijing 100080, China
    J Biol Chem 280:22508-14. 2005
    A novel angucycline metabolite, 2,3-dehydro-UWM6, was identified in a jadH mutant of Streptomyces venezuelae ISP5230. Both UWM6 and 2,3-dehydro-UWM6 could be converted to jadomycin A or B by a ketosynthase alpha (jadA) mutant of S...
  48. ncbi Inactivation of the 20S proteasome in Streptomyces lividans and its influence on the production of heterologous proteins
    Bin Hong
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical University, No 1 Tiantanxili, Beijing 100050, China
    Microbiology 151:3137-45. 2005
    ..Using the expression and secretion signals of the subtilisin inhibitor of Streptomyces venezuelae CBS762...
  49. ncbi Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis
    Xiaolin Zhang
    Academy of State Administration of Grain, No 11 Baiwanzhuang Avenue, Beijing, 100037, PR China
    Appl Microbiol Biotechnol 72:986-94. 2006
    ..the DNA fragment encoding the DH, enoylreductase, and KR domains from module 4 of the pikromycin PKS of Streptomyces venezuelae ATCC 15439 using a gene replacement vector pXL211...
  50. ncbi Structural basis for macrolactonization by the pikromycin thioesterase
    David L Akey
    Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, Michigan 48109 2216, USA
    Nat Chem Biol 2:537-42. 2006
    ..of macrolactone ring formation catalyzed by the pikromycin polyketide synthase thioesterase domain from Streptomyces venezuelae. A pentaketide phosphonate mimic of the final pikromycin linear chain-elongation intermediate was ..
  51. ncbi Total synthesis of narbonolide and biotransformation to pikromycin
    Lakshmanan Venkatraman
    Department of Medicinal Chemistry, 8 101 WDH, University of Minnesota, Minneapolis, Minnesota 55455 0353, USA
    J Org Chem 71:9853-6. 2006
    ..A pikAI deletion mutant of Streptomyces venezuelae was used to biotransform synthetic narbonolide to pikromycin by glycosylation and oxidation in vivo...
  52. doi Combinatorial biosynthesis and antibacterial evaluation of glycosylated derivatives of 12-membered macrolide antibiotic YC-17
    Pramod B Shinde
    Department of Chemistry and Nano Sciences, Ewha Womans University, Seoul 120 750, Republic of Korea Institute of Nano Biotechnology, Ewha Womans University, Seoul 120 750, Republic of Korea
    J Biotechnol 168:142-8. 2013
    ..the gene encoding a substrate-flexible glycosyltransferase DesVII were constructed and introduced into Streptomyces venezuelae YJ003 mutant strain bearing a deletion of a desosamine biosynthetic (des) gene cluster...
  53. pmc Evolutionary relationships among actinophages and a putative adaptation for growth in Streptomyces spp
    Margaret C M Smith
    Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    J Bacteriol 195:4924-35. 2013
    ..e., use of the rare UUA codon, to control translation of the essential phage protein, the terminase. The Streptomyces venezuelae generalized transducing phage SV1 was used to predict the presence of other generalized transducing ..
  54. pmc Genes required for aerial growth, cell division, and chromosome segregation are targets of WhiA before sporulation in Streptomyces venezuelae
    Matthew J Bush
    Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom
    MBio 4:e00684-13. 2013
    ..ChIP-seq) and microarray transcriptional profiling, exploiting a new model organism for the genus, Streptomyces venezuelae, which sporulates in liquid culture...
  55. doi Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities
    Ah Reum Han
    Interdisciplinary Programs of Bioengineering, Seoul National University, Seoul 151 742, Republic of Korea
    Appl Microbiol Biotechnol 93:1147-56. 2012
    A 14-membered macrolide antibiotic narbomycin produced from Streptomyces venezuelae ATCC 15439 is composed of polyketide macrolactone ring and D-desosamine as a deoxysugar moiety, which acts as an important determinant of its ..
  56. doi Enhanced production of thrombinase by Streptomyces venezuelae: kinetic studies on growth and enzyme production of mutant strain
    Balakrishnan Naveena
    Department of Chemical Engineering, A C College of Technology, Anna University Chennai, Chennai 600 025, India
    Bioresour Technol 111:417-24. 2012
    This investigation provides the enhanced production of thrombinase, a fibrinolytic enzyme using mutant Streptomyces venezuelae. Initially the mutagenesis of the marine isolate was done by UV and Ethyl methane sulfonate (EMS) and their ..
  57. doi Polyester hydrolytic and synthetic activity catalyzed by the medium-chain-length poly(3-hydroxyalkanoate) depolymerase from Streptomyces venezuelae SO1
    Marta Santos
    Enzyme and Cell Technology Group, Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country UPV EHU, P O Box 644, 48080, Bilbao, Spain
    Appl Microbiol Biotechnol 97:211-22. 2013
    ..medium-chain-length polyhydroxyalkanote (MCL-PHA) depolymerase from an isolate identified as Streptomyces venezuelae SO1 was purified to electrophoretic homogeneity and characterized...
  58. doi Type II thioesterase gene (ECO-orf27) from Amycolatopsis orientalis influences production of the polyketide antibiotic, ECO-0501 (LW01)
    Yang Shen
    School of Biotechnology, East China University of Science and Technology, Meilong Rd 130, Shanghai, People s Republic of China
    Biotechnol Lett 34:2087-91. 2012
    ..Type II thioesterase gene pikAV from Streptomyces venezuelae could complement ECO-orf27 in A...
  59. doi New methymycin derivatives of Streptomyces venezuelae ATCC 15439 and their inhibitory effects on human T cell proliferation mediated by PMA/ionomycin
    Rong Ding
    College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China
    Arch Pharm Res 35:1567-72. 2012
    ..and 3'-demethyldeoxymethymycin (2), together with seven known ones (3-9), were obtained from the strain Streptomyces venezuelae ATCC 15439. Their structures were determined on the basis of IR, MS, 1D and 2D NMR data...
  60. pmc Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product
    Eun Ji Kim
    Department of Chemistry and Nano Sciences, Ewha Womans University, Seoul 120 750, Republic of Korea
    Org Lett 14:5824-7. 2012
    ..cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the ..
  61. doi An efficacious degradation of pesticide by salt tolerant Streptomyces venezuelae ACT 1
    Balakrishnan Naveena
    Department of Chemical Engineering, AC College of Technology, Anna University Chennai, Chennai 600 025, India
    Bioresour Technol 132:378-82. 2013
    Degradation of the organophosphorus pesticide has been studied using the marine isolate, Streptomyces venezuelae ACT1. The organism exhibited a specific growth rate of 0.371h(-1) and the organophosphorus hydrolase activity rate as 0...
  62. pmc The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds
    Steven J Malcolmson
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:8483-8. 2013
    ..from Streptomyces bernensis UC 5144, its heterologous expression in Streptomyces lividans TK24 and Streptomyces venezuelae ATCC 10712, and detection of variant and incompletely processed scaffolds...
  63. doi Use of Strep-tag II for rapid detection and purification of Mycobacterium tuberculosis recombinant antigens secreted by Streptomyces lividans
    Julio C Ayala
    Institute of Pharmacy and Food, University of Havana, Havana, Cuba
    J Microbiol Methods 94:192-8. 2013
    ..protein 1), were equipped with a 3'-Strep-tag® II-encoding sequence and placed under control of the Streptomyces venezuelae CBS762.70 subtilisin inhibitor (vsi) transcriptional, translational and signal sequences...
  64. pmc Disruption of rimP-SC, encoding a ribosome assembly cofactor, markedly enhances the production of several antibiotics in Streptomyces coelicolor
    Yuanyuan Pan
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    Microb Cell Fact 12:65. 2013
    ..the close relationship between protein synthesis and the production of secondary metabolites, the function of ribosome assembly cofactor RimP on antibiotics production was studied in Streptomyces coelicolor and Streptomyces venezuelae.
  65. ncbi Further biological and molecular characterization of actinophage VWB
    J Anne
    Laboratory of Microbiology, University of Leuven, Belgium
    J Gen Microbiol 136:1365-72. 1990
    ..f.u. Although phage VWB could infect only Streptomyces venezuelae ETH 14630 (ATCC 40755), of six different S...
  66. ncbi Cloning and sequence analysis of a recA-like gene from Streptomyces venezuelae ISP5230
    W Yao
    Biology Department, Dalhousie University, Halifax, Nova Scotia, Canada
    FEMS Microbiol Lett 118:51-6. 1994
    When genomic DNA fragments from Streptomyces venezuelae ISP5230 were probed at moderate stringency with recA from Mycobacterium tuberculosis, a 2.0-kb SmaI fragment was identified. The fragment was isolated by cloning a BamHI digest of S...
  67. ncbi A role for pabAB, a p-aminobenzoate synthase gene of Streptomyces venezuelae ISP5230, in chloramphenicol biosynthesis
    M P Brown
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Microbiology 142:1345-55. 1996
    Mutagenesis of Streptomyces venezuelae ISP5230 and selection for P-aminobenzoic acid-dependent growth in the presence of sulfanilamide yielded pab mutants (VS519 and VS620) that continued to produce chloramphenicol (Cm), although with ..
  68. ncbi Cloning, sequencing and disruption of a bromoperoxidase-catalase gene in Streptomyces venezuelae: evidence that it is not required for chlorination in chloramphenicol biosynthesis
    S J Facey
    Institut fur Mikrobiologie, Universitat Hohenheim, Stuttgart, Germany
    Microbiology 142:657-65. 1996
    Genomic DNA libraries of Streptomyces venezuelae ISP5230 and of a mutant blocked at the chlorination step of chloramphenicol biosynthesis were probed by hybridization with a synthetic oligonucleotide corresponding to the N-terminal amino ..
  69. ncbi An acyl-coenzyme A carboxylase encoding gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230
    L Han
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Microbiology 146:903-10. 2000
    ..region of chromosomal DNA lying between jadR1 and jadI in the gene cluster for jadomycin biosynthesis in Streptomyces venezuelae ISP5230 detected an ORF encoding 584 amino acids similar in sequence to the biotin carboxylase (BC) and ..
  70. pmc The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism
    T Izard
    Department of Biochemistry, University of Leicester, Leicester LE1 7RH, UK
    EMBO J 19:2690-700. 2000
    Chloramphenicol (Cm), produced by the soil bacterium Streptomyces venezuelae, is an inhibitor of bacterial ribosomal peptidyltransferase activity...
  71. pmc Structural basis for chloramphenicol tolerance in Streptomyces venezuelae by chloramphenicol phosphotransferase activity
    T Izard
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Protein Sci 10:1508-13. 2001
    b>Streptomyces venezuelae synthesizes chloramphenicol (Cm), an inhibitor of ribosomal peptidyl transferase activity, thereby inhibiting bacterial growth...
  72. ncbi Oxidation of lincomycin by hydrogen peroxide restricts its potential biotransformation with haloperoxidases
    S Pospisil
    Institute of Microbiology, Academy of Sciences of the Czech Republic, 124 20 Prague, Czechia
    Folia Microbiol (Praha) 46:376-8. 2001
    Lincomycin biotransformation was conducted by using Streptomyces venezuelae and Streptomyces phaeochromogenes cell-free extracts...
  73. ncbi Biosynthesis of sulfur-containing amino acids in Streptomyces venezuelae ISP5230: roles for cystathionine beta-synthase and transsulfuration
    Z Chang
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Microbiology 148:2135-47. 2002
    A 0.5 kb fragment of Streptomyces venezuelae ISP5230 genomic DNA was amplified by PCR using primers based on consensus sequences of cysteine synthase isozyme A from bacteria...
  74. ncbi Para-position derivatives of fungal anthelmintic cyclodepsipeptides engineered with Streptomyces venezuelae antibiotic biosynthetic genes
    Koji Yanai
    Microbiological Resources and Technology Laboratories, Meiji Seika Kaisha, Ltd, 788 Kayama, Odawara shi, Kanagawa 250 0852, Japan
    Nat Biotechnol 22:848-55. 2004
    ..PF1022. Three genes cloned from Streptomyces venezuelae, and required for the biosynthesis of p-aminophenylpyruvate from chorismate in the chloramphenicol ..
  75. ncbi Novel jadomycins: incorporation of non-natural and natural amino acids
    David L Jakeman
    College of Pharmacy, Dalhousie University, 5968 College Street, Halifax, Nova Scotia, B3H 3J5, Canada
    Bioorg Med Chem Lett 15:1447-9. 2005
    Electrospray ionization mass spectrometry of extracts from Streptomyces venezuelae ISP5230 cultures grown on chemically synthesized non-natural L-amino acids, D-amino acids or any of the 20 natural amino acids demonstrated incorporation ..
  76. ncbi Novel and expanded jadomycins incorporating non-proteogenic amino acids
    David L Jakeman
    College of Pharmacy, Dalhousie University, 5968 College Street, Halifax, B3H 3J5, NS, Canada
    Bioorg Med Chem Lett 15:5280-3. 2005
    Jadomycin B is a secondary metabolite produced, in response to stress, by Streptomyces venezuelae ISP5230 grown in nutrient-deprived media...
  77. ncbi Culture conditions improving the production of jadomycin B
    David L Jakeman
    College of Pharmacy, Dalhousie University, Halifax, NS, Canada
    J Ind Microbiol Biotechnol 33:767-72. 2006
    The jadomycins are a unique family of benzoxazolophenanthridine antibiotics produced by Streptomyces venezuelae ISP5230 following heat or ethanol shock or phage infection...
  78. pmc The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae
    David H Sherman
    Life Sciences Institute and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, USA
    J Biol Chem 281:26289-97. 2006
    The pikromycin (Pik)/methymycin biosynthetic pathway of Streptomyces venezuelae represents a valuable system for dissecting the fundamental mechanisms of modular polyketide biosynthesis, aminodeoxysugar assembly, glycosyltransfer, and ..
  79. ncbi Streptomyces gulbargensis sp. nov., isolated from soil in Karnataka, India
    Syed G Dastager
    Key Laboratory for Microbial Resources of Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming, Yunnan 650 091, P R China
    Antonie Van Leeuwenhoek 91:99-104. 2007
    ..16S rRNA gene sequence analysis revealed that strain DAS 131T was most closely related to Streptomyces venezuelae ISP 5230T (AY999739) with a sequence similarity of 99.5% (8 nucleotide differences out of 1,477)...
  80. ncbi Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation
    Jay Sung Joong Hong
    Interdisciplinary Program of Biochemical Engineering and Biotechnology, Seoul National University, San 56 1, Shilim Dong, Gwanak Gu, Seoul 151 742, Republic of Korea
    Gene 386:123-30. 2007
    ..in the biosynthesis of macrolide antibiotics, neomethymycin, methymycin and pikromycin, in Streptomyces venezuelae ATCC 15439...
  81. pmc Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine
    E Sethe Burgie
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Protein Sci 16:887-96. 2007
    ..Six enzymes are required for its biosynthesis in Streptomyces venezuelae. The focus of this article is DesV, which catalyzes the PLP-dependent replacement of a 3-keto group with ..
  82. ncbi Analysis of intracellular short organic acid-coenzyme A esters from actinomycetes using liquid chromatography-electrospray ionization-mass spectrometry
    Je Won Park
    Division of Nano Sciences and Department of Chemistry, Ewha Womans University, Seoul, Republic of Korea
    J Mass Spectrom 42:1136-47. 2007
    ..metabolomic study is demonstrated by the profiling of the intracellular CoA-ester pools in the wild-type Streptomyces venezuelae strain producing polyketide antibiotics (methymycin and pikromycin), a polyketide synthase (PKS)-deleted ..
  83. ncbi Engineering a regulatory region of jadomycin gene cluster to improve jadomycin B production in Streptomyces venezuelae
    Jian Ting Zheng
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, P O Box 2714, Beijing, 100081, People s Republic of China
    Appl Microbiol Biotechnol 76:883-8. 2007
    b>Streptomyces venezuelae ISP5230 produces a group of jadomycin congeners with cytotoxic activities. To improve jadomycin fermentation process, a genetic engineering strategy was designed to replace a 3...
  84. ncbi Heterologous expression of the kanamycin biosynthetic gene cluster (pSKC2) in Streptomyces venezuelae YJ003
    Laxmi Prasad Thapa
    Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, 100 Kalsanri, Tangjeonmyun, Asansi, Chungnam 336 708, Republic of Korea
    Appl Microbiol Biotechnol 76:1357-64. 2007
    ..It was heterologously expressed in Streptomyces venezuelae YJ003, which has the advantage of fast growth, good efficiency of the transformation host, and rapid ..
  85. ncbi Identification by gene deletion analysis of barS2, a gene involved in the biosynthesis of gamma-butyrolactone autoregulator in Streptomyces virginiae
    Yong Jik Lee
    International Center for Biotechnology, Osaka University, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Arch Microbiol 189:367-74. 2008
    ..The deduced product of barS2 possessed moderate similarity to a putative dehydrogenase of Streptomyces venezuelae, encoded by jadW2 located in similar gene arrangement to that in the regulatory island of S. virginiae...
  86. doi Total synthesis of 10-deoxymethynolide and narbonolide
    Richeng Xuan
    Department of Chemistry, Chungbuk National University, Cheongju, Chungbuk 361 763, Korea
    J Org Chem 73:1456-61. 2008
    ..These lactones are produced by pikromycin polyketide synthase from Streptomyces venezuelae. Polyketide lactones, 10-deoxymethynolide and narbonolide, which contain 12- and 14-membered rings, ..
  87. pmc Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae
    Won Seok Jung
    Division of Nano Sciences, Ewha Womans University, Seoul 120 750, South Korea
    Appl Environ Microbiol 74:1972-9. 2008
    To elevate the production level of heterologous polyketide in Streptomyces venezuelae, an additional copy of the positive regulatory gene pikD was introduced into the pikromycin (Pik) polyketide synthase (PKS) deletion mutant of S...
  88. doi Biosynthesis of spectinomycin: heterologous production of spectinomycin and spectinamine in an aminoglycoside-deficient host, Streptomyces venezuelae YJ003
    L P Thapa
    Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, Chungnam, Republic of Korea
    J Appl Microbiol 105:300-8. 2008
    To obtain spectinomycin and spectinamine by heterologous expression into the biosynthetic deoxysugar (desosamine) gene-deleted host Streptomyces venezuelae YJ003.
  89. doi Heterologous expression of metK1-sp and afsR-sp in Streptomyces venezuelae for the production of pikromycin
    Sushila Maharjan
    Institute of Biomolecule Reconstruction, Department of Pharmaceutical Engineering, SunMoon University, 100, Kalsan ri, Tangjeong myeon, Asan Si, Chungnam 336 708, Republic of Korea
    Biotechnol Lett 30:1621-6. 2008
    ..The elevated transcripts of the pikD and ketosynthase genes were consistent with the enhanced production of pikromycin...
  90. doi Metabolic engineering of noviose: heterologous expression of novWUS and generation of a new hybrid antibiotic, noviosylated 10-deoxymethynolide/narbonolide, from Streptomyces venezuelae YJ003-OTBP1
    Binod Babu Pageni
    Institute of Biomolecule Reconstruction, Department of Pharmaceutical Engineering, Sun Moon University, 100, Kalsan ri, Tangjeong myeon, Asan Si, Chungnam 336 708, Republic of Korea
    Biotechnol Lett 30:1609-15. 2008
    ..This established the function of novWUS and, at the same time, it also proved that the noviosyl derivative of 10-deoxymethynolide(2)/narbonolide(4) obtained from S. venezuelae YJ003-OTBP1 is a novel hybrid antibiotic...
  91. doi Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics
    Devi B Basnet
    Division of Nano Sciences, Ewha Womans University, Seoul 120 750, Republic of Korea
    J Biotechnol 135:92-6. 2008
    ..gene pikC, which encodes the substrate-flexible hydroxylase from the pikromycin biosynthetic pathway of Streptomyces venezuelae, in the eryBV deletion mutant strain of Sac. erythraea led to 5-O-desosaminyl erythronolide A production.
  92. pmc Structure of Deinococcus radiodurans tunicamycin-resistance protein (TmrD), a phosphotransferase
    Ulrike Kapp
    European Synchrotron Radiation Facility, 6 rue Jules Horowitz, BP 220, 38043 Grenoble, France
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:479-86. 2008
    ..strong structural similarity to the family of nucleoside monophosphate kinases and to the chloramphenicol phosphotransferase of Streptomyces venezuelae, suggesting that the mode of action is possibly by phosphorylation of tunicamycin.
  93. pmc Genetic dissection of the biosynthetic route to gentamicin A2 by heterologous expression of its minimal gene set
    Je Won Park
    Division of Nano Sciences, Ewha Womans University, 11 1 Daehyung dong, Seodaemun gu, Seoul 120 750, Republic of Korea
    Proc Natl Acad Sci U S A 105:8399-404. 2008
    ..related aminoglycoside-producing strains were introduced into a nonaminoglycoside producing strain of Streptomyces venezuelae. Heterologous expression of different combinations of putative 2-DOS biosynthetic genes revealed that a ..
  94. pmc The fused TrpEG from Streptomyces venezuelae is an anthranilate synthase, not a 2-amino-2-deoxyisochorismate [corrected] (ADIC) synthase
    Meseret Ashenafi
    Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, Washington, DC 20059, USA
    Ethn Dis 18:S2-9-13. 2008
    The chloramphenicol producer Streptomyces venezuelae contains an enzyme, SvTrpEG, that has a high degree of amino acid sequence similarity to the phenazine biosynthetic enzyme PhzE of certain species of Pseudomonas...
  95. doi Heterologous production of epothilones B and D in Streptomyces venezuelae
    Sung Ryeol Park
    Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120 750, Republic of Korea
    Appl Microbiol Biotechnol 81:109-17. 2008
    ..The entire epothilone biosynthetic gene cluster was heterologously expressed in an engineered strain of Streptomyces venezuelae bearing a deletion of pikromycin polyketide synthase gene cluster...
  96. pmc The methymycin/pikromycin pathway: a model for metabolic diversity in natural product biosynthesis
    Jeffrey D Kittendorf
    University of Michigan Life Sciences Institute, Department of Medicinal Chemistry, 210 Washtenaw Avenue, Ann Arbor, MI 48109 2216, USA
    Bioorg Med Chem 17:2137-46. 2009
    ..substrate flexibility, combining to produce six structurally diverse macrolide antibiotics in Streptomyces venezuelae. Thus, it is appealing to consider that the pikromycin biosynthetic enzymes could be leveraged for high-..
  97. pmc Antimicrobial activities of jadomycin B and structurally related analogues
    David L Jakeman
    College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada
    Antimicrob Agents Chemother 53:1245-7. 2009
    ..We have isolated a series of structurally related polyketide-derived natural products from Streptomyces venezuelae ISP5230...
  98. pmc Analysis of transient and catalytic desosamine-binding pockets in cytochrome P-450 PikC from Streptomyces venezuelae
    Shengying Li
    Life Sciences Institute, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 284:5723-30. 2009
    The cytochrome P-450 PikC from Streptomyces venezuelae exhibits significant substrate tolerance and performs multiple hydroxylation reactions on structurally variant macrolides bearing the deoxyamino sugar desosamine...
  99. ncbi Identification and functional characterization of an afsR homolog regulatory gene from Streptomyces venezuelae ATCC 15439
    Sushila Maharjan
    Department of Pharmaceutical Engineering, SunMoon University, Asansi 336 708, Korea
    J Microbiol Biotechnol 19:121-7. 2009
    Sequencing analysis of a 5-kb DNA fragment from Streptomyces venezuelae ATCC 15439 revealed the presence of one 3.1-kb open reading frame (ORF), designated afsRsv...
  100. pmc A chemical screen for biological small molecule-RNA conjugates reveals CoA-linked RNA
    Walter E Kowtoniuk
    Howard Hughes Medical Institute and Department of Chemistry and Chemical Biology, 12 Oxford Street, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:7768-73. 2009
    ..Application to Escherichia coli and Streptomyces venezuelae RNA revealed an RNA-linked hydroxyfuranone or succinyl ester group, in addition to a number of other ..
  101. pmc Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator
    Linqi Wang
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Proc Natl Acad Sci U S A 106:8617-22. 2009
    ..However, such mechanisms have not been established. JadR1, an OmpR-type ARR of Streptomyces venezuelae, appears to activate the transcription of jadomycin B (JdB) biosynthetic genes while repressing its own ..

Research Grants9

  1. Seth A Darst; Fiscal Year: 2015
    ..4. Determine the structure of a new family of anti-[unreadable]: Streptomyces venezuelae [unreadable]BldN/RsbN...
  2. Janet L Smith; Fiscal Year: 2016
    ..This competing renewal application proposes to employ the versatile and well-characterized Streptomyces venezuelae pikromycin PKS, as well as a series of additional pathways whose detailed analysis has been initiated ..
  3. BIOSYNTHESIS OF AROMATIC POLYKETIDES
    CHARLES SIH; Fiscal Year: 2001
    ..For jadomycin biosynthesis in Streptomyces venezuelae: (a) Express and purify the Jad-Orf4 polyketide cyclase...
  4. GENERATION OF KETOLIDES BY COMBINATORIAL BIOSYNTHESIS
    Yongquan Xue; Fiscal Year: 1999
    ..The specific aims are: l) to develop a versatile plasmid-host expression system in Streptomyces venezuelae through which pikromycin analogues can be generated rapidly and systematically; and 2) generate novel ..
  5. GLYCOSYLATION OF POLYKETIDES BY A GLYCOSYLTRANSFERASE
    PAUL SHELDON; Fiscal Year: 2000
    ..the application): The desosaminyl transferase, DesVII, from methymycin/pikromycin biosynthetic pathway of Streptomyces venezuelae, is proposed for use in in vitro glycosylation of polyketide libraries generated by combinatorial ..
  6. Improving Glycosyltransferase by RACHITT Gene Shuffling
    Yongquan Xue; Fiscal Year: 2001
    ..RACHITT, is applied to the desosarninyl transferase (Des VII) from the pikromycin biosynthetic pathway of Streptomyces venezuelae. Des VII is an enzyme with remarkable inherent substrate flexibility, and we expect to expand further its ..
  7. COMBINATORIAL BIOSYNTHESIS AND THE PIKROMYCIN PATHWAY
    David Sherman; Fiscal Year: 2002
    ..key tailoring enzymes, and overall pathway regulation in the pikromycin (pik) biosynthetic pathway from Streptomyces venezuelae. The pikromycin system includes a set of 18 genes residing on 60 kb of DNA with a locus containing two ..
  8. BIOCHEMISTRY AND MOLECULAR GENETICS OF MITOMYCIN BIOSYNT
    David Sherman; Fiscal Year: 2003
    ..Overall, this work will provide an important theoretical and experimental base for future combinatorial biology-based production of novel AHBA-derived natural products using molecular genetic technology. ..
  9. Genomic Analysis of Antibiotic Biosynthesis
    David Sherman; Fiscal Year: 2005
    ..coelicolor genome. ..

Patents13

  1. EXPRESSION CASSETTES AND THEIR USE
    Patent Number: KR1020150139149-A; Date:2015-12-11
  2. DNA encoding methymycin and pikromycin
    Patent Number: JP2002536959-A; Date:2002-11-05
  3. Recombinant narbonolide polyketide synthase
    Patent Number: JP2002516090-A; Date:2002-06-04
  4. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  5. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  6. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
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