Genomes and Genes
Mycobacterium tuberculosis H37Rv
Alias: Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
Publications341 found, 100 shown here
- Mycobacterium tuberculosis H37Rv ESAT-6-CFP-10 complex formation confers thermodynamic and biochemical stabilityAkshaya K Meher
Molecular and Structural Biology, Central Drug Research Institute, Lucknow, India
FEBS J 273:1445-62. 2006..ESAT-6) and culture filtrate protein-10 (CFP-10), expressed from the region of deletion-1 (RD1) of Mycobacterium tuberculosis H37Rv, are known to play a key role in virulence...
- Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistancePilar Domenech
Tuberculosis Research Section, Laboratory of Immunogenetics, 12441 Parklawn Drive, Rockville, MD 20852, USA
Infect Immun 73:3492-501. 2005....
- Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosisAshley M Sherrid
Seattle Biomedical Research Institute, Seattle, Washington, United States of America
PLoS ONE 5:e11622. 2010..In sum, this study defines a new transcriptional response of MTB with potential relevance to disease, and implicates ClgR as a regulator involved in resumption of replication following hypoxia...
- DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosisHelena I M Boshoff
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook II, 12441 Parklawn Drive, Rockville, MD 20852, USA
Cell 113:183-93. 2003..These results may indicate a potential new target for therapeutic intervention...
- Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cellsKamalakannan Velmurugan
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
PLoS Pathog 3:e110. 2007..tuberculosis and support a direct causal relationship between virulence of pathogenic mycobacteria and their ability to inhibit macrophage apoptosis...
- Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthaseLuiz Pedro S de Carvalho
Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
Chem Biol 17:323-32. 2010..Thus, Rv1248c encodes an HOA synthase...
- Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinasesSladjana Prisic
Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:7521-6. 2010..tuberculosis and create a resource for understanding how specific phosphorylation events modulate protein activity. The results further provide the potential to predict likely cognate STPKs for newly identified phosphoproteins...
- Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophagesSushil Kumar Pathak
Bose Institute, Department of Chemistry, Kolkata 700 009, India
Nat Immunol 8:610-8. 2007....
- The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expressionSteven C Derrick
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
Cell Microbiol 9:1547-55. 2007..Finally, experimental results using a cell impermeable fluorescent stain suggests that the formation of membrane pores may be a primary mechanism by which ESAT6 evokes an apoptotic response...
- Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS)J E Graham
Department of Biology, Washington University, St Louis, MO 63130, USA
Proc Natl Acad Sci U S A 96:11554-9. 1999..tuberculosis genes expressed in response to host interaction, will allow the study of gene expression in a variety of microorganisms, including expression resulting from interaction with human tissues in natural disease states...
- Mycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survivalAmit Singh
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 104:11562-7. 2007..Taken together, our results suggest that WhiB3 is an intracellular redox sensor that integrates environmental redox signals with core intermediary metabolism...
- Polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteriaKamakshi Sureka
Department of Chemistry, Bose Institute, 93 1 Acharya Prafulla Chandra Road, Calcutta 700009, India
Mol Microbiol 65:261-76. 2007..smegmatis and M. tuberculosis. Downregulation of ppk1 led to impaired survival of M. tuberculosis in macrophages. PolyP plays a central role in the stress response of mycobacteria...
- Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur clusterLaura J Smith
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
Biochem J 432:417-27. 2010..A model incorporating regulation of whiB1 expression in response to nitric oxide and cAMP is discussed with implications for sensing two important signals in establishing M. tuberculosis infections...
- mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitorsE De Rossi
Department of Genetics and Microbiology, University of Pavia, 27100 Pavia, Italy
J Bacteriol 180:6068-71. 1998..The gene appears to code for a protein containing four transmembrane domains. Studies of [3H]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP...
- The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesisT D Sirakova
Neurobiotechnology Center and Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
J Biol Chem 276:16833-9. 2001..With this sulfolipid-deficient mutant, it should be possible to test for the postulated important roles for sulfolipids in the pathogenesis of M. tuberculosis...
- NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis. Crystal structure of the adenylation domain and identification of novel inhibitorsSandeep Kumar Srivastava
Division Molecular and Structural Biology, Central Drug Research Institute, Chattar Manzil, Mahatma Gandhi Marg, Lucknow 226001, India
J Biol Chem 280:30273-81. 2005..The results can be used as the basis for rational design of novel antibacterial agents...
- Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1Henrik Ingvarsson
Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Box 596, SE 751 24 Uppsala, Sweden
Acta Crystallogr D Biol Crystallogr 63:249-59. 2007..The models also reveal structural differences within the N-terminal hairpin-loop domain, which possibly reflect the significant differences in amino-acid sequence between Mt ClpP1 and other ClpP homologues in this region...
- Lsr2 of Mycobacterium represents a novel class of H-NS-like proteinsBlair R G Gordon
Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto ON M5S 1A8, Canada
J Bacteriol 190:7052-9. 2008..Taken together, our results demonstrate unequivocally that Lsr2 is an H-NS-like protein...
- Functional genomics reveals extended roles of the Mycobacterium tuberculosis stress response factor sigmaHSmriti Mehra
Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Covington, LA 70433, USA
J Bacteriol 191:3965-80. 2009..sigma(H) caused the induction of the ATP-dependent clp proteolysis regulon, likely mediated by a transcription factor encoded by Rv2745c, several members of the mce1 virulence regulon, and the sulfate acquisition/transport network...
- Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosisMeetu Gupta
Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Delhi 110007, India
J Biol Chem 284:34723-34. 2009..Thus, our data provides initial clues for a possible regulation of PapA5 and hence the phthiocerol dimycocerosate biosynthesis by PknB, either by direct phosphorylation of PapA5 or indirectly through Rv0019c...
- Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active siteAnnette K Roos
Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Box 596, SE 751 24 Uppsala, Sweden
J Mol Biol 335:799-809. 2004..Docking studies allow additional insights into the reactions of all three enzymes, and show that many features of the mechanism are preserved despite the different catalytic components...
- A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factorLisa Rickman
Division of Mycobacterial Research, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Mol Microbiol 56:1274-86. 2005..In summary, it has been shown that Rv3676 is a direct regulator of rpfA expression, and because rpfA codes for a resuscitation promoting factor this may implicate Rv3676 in reactivation of dormant M. tuberculosis infections...
- Co-expression of DevR and DevR(N)-Aph proteins is associated with hypoxic adaptation defect and virulence attenuation of Mycobacterium tuberculosisShyamasree De Majumdar
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
PLoS ONE 5:e9448. 2010..DevR regulon genes are powerfully induced in vivo implicating them in bacterial adaptation to host control strategies. A better understanding of DevR function will illumine the way for new strategies to control and treat tuberculosis...
- The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatisYuqing Li
National Key Laboratory of Agricultural Microbiology, Center for Proteomics Research, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
BMC Microbiol 10:242. 2010..tuberculosis replication initiator gene, dnaA. However, the dnaA promoter binding sites and many potential target genes for MtrA have yet to be precisely characterized...
- Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulenceYamini M Ohol
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA
Cell Host Microbe 7:210-20. 2010..As the key ESX-1 substrates ESAT-6 and CFP-10 are highly immunogenic, fine-tuning of their secretion by MycP1 may balance virulence and immune detection and be essential for successful maintenance of long-term M. tuberculosis infection...
- Diarylquinolines target subunit c of mycobacterial ATP synthaseAnil Koul
Department of Antimicrobial Research, Tibotec BVBA, Johnson and Johnson, Turnhoutseweg 30, B 2340 Beerse, Belgium
Nat Chem Biol 3:323-4. 2007..Here we establish by genetic, biochemical and binding assays that the oligomeric subunit c (AtpE) of ATP synthase is the target of R207910. Thus targeting energy metabolism is a new, promising approach for antibacterial drug discovery...
- Mutations found in the pncA gene of Mycobacterium tuberculosis in clinical pyrazinamide-resistant isolates from a local region of ChinaH Zhang
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
J Int Med Res 37:1430-5. 2009..These results show the molecular mechanism of pyrazinamide resistance in China and may also contribute towards the prevention of tuberculosis in China...
- Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) protein domains target LipY lipases of pathogenic mycobacteria to the cell surface via the ESX-5 pathwayMaria H Daleke
Department of Medical Microbiology and Infection Control, VU University Medical Centre, 1081 BT Amsterdam, The Netherlands
J Biol Chem 286:19024-34. 2011..In conclusion, both PE and PPE domains contain a signal required for secretion of LipY by the ESX-5 system, and these domains are proteolytically removed upon translocation...
- Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosisM A Horwitz
Department of Medicine, School of Medicine, University of California, Los Angeles 90024
Proc Natl Acad Sci U S A 92:1530-4. 1995..tuberculosis are candidate components of a subunit vaccine against tuberculosis and provides compelling support for the concept that extracellular proteins of intracellular pathogens are key immunoprotective molecules...
- A riboswitch regulates expression of the coenzyme B12-independent methionine synthase in Mycobacterium tuberculosis: implications for differential methionine synthase function in strains H37Rv and CDC1551Digby F Warner
Molecular Mycobacteriology Research Unit, National Health Laboratory Service, P O Box 1038, Johannesburg 2000, South Africa
J Bacteriol 189:3655-9. 2007..Expression analysis confirmed that the B(12) riboswitch is a transcriptional regulator of metE in M. tuberculosis...
- Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosisLia Danelishvili
Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of America
PLoS ONE 5:e10474. 2010..The mechanisms by which M. tuberculosis H37Rv strain suppress apoptosis and escapes human macrophage killing was investigated...
- Insights into the function of the WhiB-like protein of mycobacteriophage TM4--a transcriptional inhibitor of WhiB2Jan Rybniker
1st Department of Internal Medicine, Division of Infectious Diseases, 50924 Cologne, Germany
Mol Microbiol 77:642-57. 2010..Thus, we provide substantial evidence supporting the hypothesis of viral and bacterial WhiB proteins being important Fe-S containing transcriptional regulators with DNA-binding capability...
- Copper resistance is essential for virulence of Mycobacterium tuberculosisFrank Wolschendorf
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 108:1621-6. 2011..Hence, this study reveals an Achilles heel of Mtb that might be a promising target for tuberculosis chemotherapy...
- Definition of the mycobacterial SOS box and use to identify LexA-regulated genes in Mycobacterium tuberculosisElaine O Davis
Division of Mycobacterial Research, National Institute for Medical Research, London NW7 1AA, England
J Bacteriol 184:3287-95. 2002..Curiously, of the remaining 10 genes predicted to be LexA regulated, 7 are members of the M. tuberculosis 13E12 repeat family, which has some of the characteristics of mobile elements...
- Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosisS V Ramaswamy
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
Antimicrob Agents Chemother 44:326-36. 2000..Taken together, the results indicate that there are multiple molecular pathways to the EMB resistance phenotype...
- Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulatorMarek Fol
Biomedical Research, The University of Texas Health Center at Tyler, 11937 U S Hwy 271, Tyler, TX 75708 3154, USA
Mol Microbiol 60:643-57. 2006..We propose that proliferation of M. tuberculosis in vivo depends, in part, on the optimal ratio of phosphorylated to non-phosphorylated MtrA response regulator...
- Mycobacterium tuberculosis HBHA protein reacts strongly with the serum immunoglobulin M of tuberculosis patientsA Rum Shin
Department of Microbiology, College of Medicine, Chungnam National University, 6 Muwha Dong, Jung ku, Daejeon 301 747, Korea
Clin Vaccine Immunol 13:869-75. 2006..tuberculosis into epithelial cells. These findings suggest that IgM antibody to HBHA may play a role in protection against extrapulmonary dissemination...
- Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancyRyan W Honaker
University of Colorado Denver, Department of Microbiology, Aurora, CO 80045, USA
Infect Immun 77:3258-63. 2009..Thus, M. tuberculosis has evolved a system whereby it responds to hypoxic conditions in a stepwise fashion as it enters an anaerobic state...
- Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosisM Analise Zaunbrecher
Microbiology and Molecular Genetics Graduate Program, Department of Microbiology and Immunology, Rollins Research Center, Emory University, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 106:20004-9. 2009..This may help avoid excluding a potentially effective drug from a treatment regimen for drug-resistant TB...
- Characterization of the major membrane protein of virulent Mycobacterium tuberculosisB Y Lee
Department of Microbiology, Colorado State University, Fort Collins 80523
Infect Immun 60:2066-74. 1992..Immunoblotting indicated that this protein is highly expressed in the virulent strains of M. tuberculosis. Its application to sera from patients with pulmonary tuberculosis showed promise as a serodiagnostic tool...
- Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosisClaudia Sala
Global Health Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
Mol Microbiol 71:1102-16. 2009..The existence of a potential regulatory loop between cell wall integrity and ATP production was previously unknown...
- Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosisD A Rozwarski
Department of Biochemistry and Biophysics, Texas A and M University, College Station, TX 77843, USA
Science 279:98-102. 1998....
- Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprAHongjun He
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Rd, P O Box 26509, Milwaukee, WI 53226, USA
J Bacteriol 187:202-12. 2005..Identification of the genetic determinants regulated by MprA will ultimately enhance our understanding of the mechanisms utilized by M. tuberculosis to undergo latency...
- Crystallographic studies of shikimate binding and induced conformational changes in Mycobacterium tuberculosis shikimate kinaseBalvinder Dhaliwal
Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
FEBS Lett 574:49-54. 2004..Detailed knowledge of shikimate binding is an important step in the design of inhibitors of SK, which have potential as novel anti-tuberculosis agents...
- Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation blockRosa Milagros Corrales
Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universités de Montpellier II et I, CNRS, UMR 5235, Case 107, Place Eugene Bataillon, 34095 Montpellier Cedex 05, France
J Biol Chem 287:26187-99. 2012..Our results add new insight into the importance of mycolic acid cyclopropane rings in the PMB and provide the first evidence of a Ser/Thr kinase-dependent mechanism for modulating mycolic acid composition and PMB...
- Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acidAmanda S Fivian-Hughes
Division of Mycobacterial Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Microbiology 158:308-18. 2012..We also demonstrate that thyA deletion confers M. tuberculosis p-aminosalicylic acid resistance, and show by complementation studies that ThyA T202A and V261G appear to be functional and non-functional, respectively...
- Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate bindingRafael G Silva
Centro de Pesquisas em Biologia Molecular e Funcional, Faculdade de Biociências e Faculdade de Farmácia, Instituto de Pesquisas Biomédicas, PUCRS, 6681 92 A Av Ipiranga, 90619 900, Porto Alegre, RS, Brazil
Arch Biochem Biophys 471:1-10. 2008..Moreover, modest affinity loss occurs when the substrates bind to the monomer as compared to the dimer of MabA. A mechanism of substrate binding to MabA is proposed on the basis of the experimental data...
- Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyXJoshua H Hunter
Department of Chemistry, University of Washington, Seattle, Washington, United States of America
PLoS ONE 3:e2237. 2008..To facilitate future small molecule inhibitors against these proteins, a detailed enzymatic characterization was necessary...
- Expression, essentiality, and a microtiter plate assay for mycobacterial GlmU, the bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferaseWenli Zhang
Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian 116044, China
Int J Biochem Cell Biol 40:2560-71. 2008..In Mycobacterium tuberculosis H37Rv genome, Rv1018c shows strong homology to the GlmU protein involved in the formation of UDP-GlcNAc ..
- Genetic evaluation of relationship between mutations in rpoB and resistance of Mycobacterium tuberculosis to rifampinAnna Zaczek
Institute for Medical Biology, Polish Academy of Sciences, Lodz, Poland
BMC Microbiol 9:10. 2009..Among many mutations identified in the rpoB gene, few were verified by molecular genetic methods as responsible for resistance to rifampin (RMP)...
- Mycobacterium tuberculosis PhoP recognizes two adjacent direct-repeat sequences to form head-to-head dimersSankalp Gupta
Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India
J Bacteriol 191:7466-76. 2009....
- M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substratesJoseph G Sklar
Immunology Program, Sloan Kettering Institute, New York, NY 10021, USA
Mol Microbiol 77:605-17. 2010....
- The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of actionFranca Rossi
DiSCAFF, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
Nucleic Acids Res 39:7316-28. 2011..tuberculosis...
- The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutolRoberto Colangeli
Division of Infectious Disease and the Center for Emerging Pathogens, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
Mol Microbiol 55:1829-40. 2005..Drugs designed to inhibit the iniA gene product may shorten the time required to treat tuberculosis and may help prevent the clinical emergence of drug resistance...
- Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survivalVeerabadran Dheenadhayalan
Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Building 29, Room 503, HFM 431, 29 Lincoln Drive, Bethesda, MD 20892, USA
Microbes Infect 8:262-72. 2006....
- Deletion of the Mycobacterium tuberculosis alpha-crystallin-like hspX gene causes increased bacterial growth in vivoYanmin Hu
Medical Microbiology, Department of Cellular and Molecular Sciences, St George s Hospital Medical School, London SW17 0RE, United Kingdom
Infect Immun 74:861-8. 2006..We also confirmed that constitutive expression of hspX slows growth in vitro, and we propose that hspX plays an active role in slowing the growth of M. tuberculosis in vivo immediately following infection...
- Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activationGoragot Wisedchaisri
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
J Mol Biol 378:227-42. 2008..Our structures suggest a mode of DosR activation by phosphorylation via a helix rearrangement mechanism...
- Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37RvKirsty J McLean
Manchester Interdisciplinary Biocentre, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom
J Biol Chem 283:33406-16. 2008..Collectively, data point to an important cellular role for CYP121 and highlight its potential as a novel Mtb drug target...
- Powerful induction of divergent tgs1-Rv3131 genes in Mycobacterium tuberculosis is mediated by DevR interaction with a high-affinity site and an adjacent cryptic low-affinity siteSantosh Chauhan
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
J Bacteriol 191:6075-81. 2009....
- embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutationClaudia Plinke
Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany
J Antimicrob Chemother 65:1359-67. 2010..Here, other mutations in the embCAB operon are suggested to be involved in resistance development...
- Molecular characterization of secretory proteins Rv3619c and Rv3620c from Mycobacterium tuberculosis H37RvAnjum Mahmood
Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow, India
FEBS J 278:341-53. 2011Rv3619c and Rv3620c are the secretory, antigenic proteins of the ESAT-6/CFP-10 family of Mycobacterium tuberculosis H37Rv. In this article, we show that Rv3619c interacts with Rv3620c to form a 1 : 1 heterodimeric complex with a ..
- PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activityAmit Parikh
National Institute of Immunology, New Delhi, India
J Mol Biol 386:451-64. 2009..These findings imply a role for PknB in regulating peptidoglycan synthesis by modulating the acetyltransferase activity of GlmU...
- Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosisNathan A Lack
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX13QT, UK
Biochem J 418:369-78. 2009..As propionyl-CoA is a product of cholesterol catabolism, we propose that NAT could have a role in the utilization of this important cofactor...
- inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosisA Banerjee
Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461
Science 263:227-30. 1994..These results suggest that InhA is likely a primary target of action for INH and ETH...
- The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophagesJ J De Voss
Department of Chemistry, University of Queensland, Brisbane, Queensland, Australia 4067
Proc Natl Acad Sci U S A 97:1252-7. 2000..tuberculosis. These results provide conclusive evidence linking this genetic locus to siderophore production...
- Crystal structure of the transcription elongation/anti-termination factor NusA from Mycobacterium tuberculosis at 1.7 A resolutionB Gopal
Division of Protein Structure, National Institute for Medical Research, Mill Hill, London, UK
J Mol Biol 314:1087-95. 2001..They also allow us to rationalize certain termination-defective and cold shock-sensitive mutations in the nusA gene that have been studied in Escherichia coli...
- Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinasesTracy A Young
Department of Molecular and Cell Biology, 229 Stanley Hall 3206, University of California, Berkeley, California 94720 3206, USA
Nat Struct Biol 10:168-74. 2003..The structural and chemical similarities of PknB to metazoan homologs support a universal activation mechanism of Ser/Thr protein kinases in prokaryotes and eukaryotes...
- Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6Philip S Renshaw
Department of Biochemistry, University of Leicester, Leicester, UK
EMBO J 24:2491-8. 2005....
- Polyphosphate kinase 2: a modulator of nucleoside diphosphate kinase activity in mycobacteriaKamakshi Sureka
Department of Chemistry, Bose Institute, 93 1 Acharya Prafulla Chandra Road, Kolkata 700009, India
Mol Microbiol 74:1187-97. 2009..Downregulation of ppk2 impairs survival of M. tuberculosis in macrophages, suggesting that PPK2 plays an important role in the physiology of the bacteria residing within macrophages...
- CtpV: a putative copper exporter required for full virulence of Mycobacterium tuberculosisSarah K Ward
Department of Pathobiological Sciences, University of Wisconsin Madison, 1656 Linden Drive, Madison, WI 53706, USA
Mol Microbiol 77:1096-110. 2010..tuberculosis, supporting the hypothesis that copper response could be important to intracellular pathogens, in general...
- Crystal structure of shikimate kinase from Mycobacterium tuberculosis reveals the dynamic role of the LID domain in catalysisYijun Gu
Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA
J Mol Biol 319:779-89. 2002..The crystal structure of MtSK (this work) and that of Erwinia chrysanthemi SK suggest a concerted conformational change of the LID and SB domains upon nucleotide binding...
- Protein kinase G from pathogenic mycobacteria promotes survival within macrophagesAnne Walburger
Biozentrum, University of Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
Science 304:1800-4. 2004....
- Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: implication in the induction of DevR target genesSantosh Chauhan
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
J Bacteriol 190:4301-12. 2008..The Rv3134c and hspX promoters have a similar architecture, wherein the proximal DevR-P binding site overlaps with the promoter -35 element. A model for the likely mode of action of DevR at these promoters is discussed...
- Interaction of DevR with multiple binding sites synergistically activates divergent transcription of narK2-Rv1738 genes in Mycobacterium tuberculosisSantosh Chauhan
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi 110029, India
J Bacteriol 190:5394-403. 2008..tuberculosis. Analysis of narK2 promoter activity indicates that it is under negative regulation in addition to DevR-mediated positive regulation and also reveals differences between M. tuberculosis and Mycobacterium bovis BCG...
- Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferaseHelen L Birch
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Mol Microbiol 69:1191-206. 2008..This newly discovered glycosyltransferase sheds further light on the complexities of Mycobacterium cell wall biosynthesis, such as in M. tuberculosis and related species and represents a potential new drug target...
- Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infectionDeepak Jayakumar
Department of Immunology, Tuberculosis Research Centre ICMR, Chetput, Chennai 600031, India
Cell Microbiol 10:365-74. 2008..These findings suggest a novel mechanism, by which PknE senses nitric oxide stress and prevents apoptosis by interfering with host signalling pathways...
- A novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosisChirajyoti Deb
Burnett College of Biomedical Sciences, University of Central Florida, Orlando, 32816, USA
J Biol Chem 281:3866-75. 2006Twenty-four putative lipase/esterase genes of Mycobacterium tuberculosis H37Rv were expressed in Escherichia coli and assayed for long-chain triacylglycerol (TG) hydrolase activity...
- Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazidV Deretic
Department of Microbiology, University of Texas Health Science Center at San Antonio 78284 7758, USA
Mol Microbiol 17:889-900. 1995..tuberculosis is paradoxical considering the fact that survival in host macrophages is regarded as a critical feature of this pathogen, it offers a partial explanation for the exquisite sensitivity of M. tuberculosis to isoniazid...
- Identification of novel intergenic repetitive units in a mycobacterial two-component system operonP Supply
Laboratoire de Microbiologie Génétique et Moléculaire, INSERM U447, Institut Pasteur de Lille, France
Mol Microbiol 26:991-1003. 1997..Analyses of the sequences at the insertion sites suggest that MIRUs disseminate by transposition into DTGA sites involved in translational coupling in polycistronic operons...
- The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxideK Heran Darwin
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
Science 302:1963-6. 2003..Thus, the mycobacterial proteasome serves as a defense against oxidative or nitrosative stress...
- CFP10 discriminates between nonacetylated and acetylated ESAT-6 of Mycobacterium tuberculosis by differential interactionLimei Meng Okkels
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
Proteomics 4:2954-60. 2004..This example shows that the access to the protein species level can be a prerequisite to understand regulation of protein-protein interaction...
- The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesisShaun B Walters
TB Center, The Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA
Mol Microbiol 60:312-30. 2006....
- C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosisPatricia A Digiuseppe Champion
Department of Microbiology and Immunology, University of California, San Francisco, 600 16th Street, Campus Box 2200, San Francisco, CA 94143 2200, USA
Science 313:1632-6. 2006..Attachment of the signal to yeast ubiquitin was sufficient for secretion from M. tuberculosis cells, demonstrating that this ESX-1 signal is portable...
- Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal modelsPaul J Converse
Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Infect Immun 77:1230-7. 2009..Our analyses reveal that the dosR and dosS genes are required for full virulence and that there may be differences in the patterns of attenuation of this mutant between the animal models studied...
- Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37RvXuelian Zhang
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Handan Road 220, Shanghai, 200433, China
Curr Microbiol 59:520-5. 2009..the two MetAPs in Mycobacterium tuberculosis, Rv0734 and Rv2861c genes encoding MetAPs from genome of Mycobacterium tuberculosis H37Rv were cloned and expressed in Escherichia coli...
- Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosisVirginie Molle
Institut de Biologie et Chimie des Proteines, Université Lyon1, IFR128 BioSciences, Lyon Gerland, Lyon Cedex 07, France
Mol Microbiol 78:1591-605. 2010..This study suggests that phosphorylation of InhA may represent an unusual mechanism that allows M. tuberculosis to regulate its mycolic acid content, thus offering a new approach to future anti-tuberculosis drug development...
- Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signalingDong Min Shin
Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
PLoS Pathog 6:e1001230. 2010..Collectively, these data indicate that Mtb Eis suppresses host innate immune defenses by modulating autophagy, inflammation, and cell death in a redox-dependent manner...
- Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-alphaSanchita Basu
Department of Chemistry, Bose Institute, 93 1 Acharya Prafulla Chandra Road, Kolkata 700009, India
J Biol Chem 282:1039-50. 2007..These results provide the first evidence that variations in the polymorphic repeats of the PGRS domain modulate the innate immune response...
- Cloning, expression, purification and characterization of DNA topoisomerase I of Mycobacterium tuberculosisF Yang
Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
Gene 178:63-9. 1996..Unlike the more well-characterized E. coli Topo I, MTb Topo I does not contain a zinc-finger DNA-binding motif in the C-terminal domain of the protein...
- Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis. Crystal structures of the enzyme alpha-aminoacrylate intermediate and an enzyme-inhibitor complexRobert Schnell
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
J Biol Chem 282:23473-81. 2007..The structure of the enzyme-peptide complex provides a framework for the design of strong binding inhibitors...
- Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosisSudha Purushothaman
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India
PLoS ONE 3:e2320. 2008..Biotin carboxyl carrier protein (BCCP) provides the co-factor for catalytic activity of ACC...
- Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coliV Nopponpunth
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
J Bacteriol 181:6814-21. 1999....
- Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selectionLucila I Castro
Abteilung Pharmazeutische Biochemie, Fakultät für Chemie und Pharmazie, Universitat Tubingen, Germany
FEBS J 272:3085-92. 2005..Data from individual and coordinated point mutations suggest a model for purine definition based on an amide switch related to that previously identified in cyclic nucleotide phosphodiesterases...
- NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: novel structure-function relationship and identification of a specific inhibitorSandeep Kumar Srivastava
Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India
Proteins 69:97-111. 2007..An analysis of conserved water in the binding site of the enzyme suggests strategies for synthesis of improved inhibitors with better specificity and potency...
- Dimerisation and structural integrity of Heparin Binding Hemagglutinin A from Mycobacterium tuberculosis: implications for bacterial agglutinationCarla Esposito
Istitute of Biostructures and Bioimaging, CNR, Naples, Italy
FEBS Lett 584:1091-6. 2010..Our data suggest that agglutination-driven cell-cell interactions do not occur via association of HBHA monomers, nor via association of HBHA dimers and open the scenario to a possible trans-dimerisation process...
- Crystal structure of DNA polymerase III β sliding clamp from Mycobacterium tuberculosisWen Jun Gui
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
Biochem Biophys Res Commun 405:272-7. 2011..tuberculosis sliding clamp and peptides derived from the α and δ subunits of Pol III, which indicated that the LF motif also plays an important role in the binding of the α and δ subunits to the sliding clamp of M. tuberculosis...
- Downregulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosisHiroki Ando
National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjuku, Tokyo 162 8655, Japan
Mol Microbiol 79:1615-28. 2011..These results suggested that downregulation of katG is a mechanism of INH resistance in M. tuberculosis and that mutations in the furA-katG intergenic region play a role in this resistance mechanism...
- Studies on structural and functional divergence among seven WhiB proteins of Mycobacterium tuberculosis H37RvMd Suhail Alam
Institute of Microbial Technology, CSIR, Chandigarh, India
FEBS J 276:76-93. 2009..The structural and functional divergence among WhiB proteins indicated that each WhiB protein is a distinguished member of the same family and together they may represent a novel redox system for M. tuberculosis...
- Cloning and B-cell-epitope mapping of MPT64 from Mycobacterium tuberculosis H37RvT Oettinger
Mycobacteria Department, Statens Seruminstitut, Copenhagen, Denmark
Infect Immun 62:2058-64. 1994The gene of the immunogenic protein MPT64 found in culture filtrates of Mycobacterium tuberculosis H37Rv was cloned and sequenced...
- A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental studyH Munier-Lehmann
Laboratoire de Chimie Structurale des Macromolecules, Institut Pasteur, France
Proteins 36:238-48. 1999..coli and on secondary structure predictions for various sequenced AKs, we propose a structural model for AK from M. tuberculosis (AKmt). Proteins 1999;36:238-248...
- Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activitySimona Miron
Institut National de la Santé et de la Recherche Médicale U350 et Institut Curie Recherche, Centre Universitaire, Batiments 110 112, F 91405 Orsay, France
Biochemistry 43:67-77. 2004..These structural and dynamic features of AKmt may be related to its low catalytic activity that is 10-fold lower than in their eukaryote counterparts...
- Screen for Mycobacterium Tuberculosis (RMI)E White; Fiscal Year: 2005..tuberculosis. 3) To study the effect of these novel inhibitors on the pantothenate pathway in M. smegmatis. 4) To co-crystallize these compounds with pantothenate synthetase to study their mode of binding ..
- Regulation of Cellular division in M. tuberculosisRICHARD SLAYDEN; Fiscal Year: 2006..Thus, the studies proposed in this application are designed to examine the replication dynamics of MTB, specifically focusing on cell cycle-regulated genes that are involved in cell division. [unreadable] [unreadable] [unreadable]..
- MYCOBACTERIAL ENVIRONMENT WITHIN MACROPHAGESLuiz Bermudez; Fiscal Year: 2003..We believe that the proposed studies will generate important information about the phagosome environment and the mycobacterial response to it. ..
- Post Translation Regulation in MycobacteriaLuiz Bermudez; Fiscal Year: 2008..In case we confirm our hypothesis, future work will address the role of Ion in M. tuberculosis [unreadable] [unreadable] [unreadable]..
- Reactivation Tuberculosis in A/JChinnaswamy Jagannath; Fiscal Year: 2005..These studies are anticipated to enhance our understanding on putative mechanisms that precede the reactivation of tuberculosis in the lungs of mice and ultimately help us to develop better strategies to prevent tuberculosis in man. ..
- Mtb Proteasome-Associated Factors and VirulenceKATERINA DARWIN; Fiscal Year: 2007..Taken together it will be important to develop faster acting drugs to new targets in Mtb in order to better treat tuberculosis in the future. ..
- Structural Studies of AIDS-Responsive DrugsVivian Cody; Fiscal Year: 2010..These results will help guide the design of species selective inhibitors. Mutagenesis studies will be carried out to test these possibilitiesin the structure-based correlations to help design novel pjDHFRinhibitors. ..
- Genetic screens to identify mycobacterial porinsMartin Pavelka; Fiscal Year: 2008..This would be an important contribution to reduce the public health burden of mycobacterial disease in the United States. [unreadable] [unreadable] [unreadable]..
- Identification of secreted proteins important for tularemia pathogenesisMartin Pavelka; Fiscal Year: 2007..Because of F. tularensis is a select agent and could be used a biological weapon, this research could potentially have a significant impact on public health in the future. [unreadable] [unreadable] [unreadable]..
- Identification of genes controlling TB in murine lungsAlexander Apt; Fiscal Year: 2005....
- Structure Function Relationship in HemeproteinsSyun Ru Yeh; Fiscal Year: 2005..Experiments are proposed to test the functional consequences of this finding. These hemeprotein systems provide an excellent model for investigating fundamental structural properties that underlie biological reactivity. ..
- Development of genetic tools for Francisella tularensisMartin Pavelka; Fiscal Year: 2004..The further development of Francisella genetics is timely, as the sequencing of the genome of the F. tularensis subsp. tularensis, strain Schu 4 is almost complete. ..
- BIOSYNTHESIS OF THE MYCOBACTERIAL PEPTIDOGLYCANMartin Pavelka; Fiscal Year: 2004..For the aims of this proposal, the Pi will study M. tuberculosis and M. smegmatis as a model organism using the techniques of classical bacterial genetics, molecular biology and biochemistry. ..
- MtrA and Mycobacterium tuberculosis proliferationMalini Rajagopalan; Fiscal Year: 2007..These experiments will establish whether oriC replication is a target of MtrA system and will improve our understanding of regulation of Mtb multiplication in vivo. [unreadable] [unreadable]..
- Congugal DNA transfer into M. tuberculosisKEITH DERBYSHIRE; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MOLECULAR ANALYSIS OF THE INSERTION ELEMENT IS903KEITH DERBYSHIRE; Fiscal Year: 2004..3. To establish biochemical assays that will identify specific transposase-DNA contacts, define stable domains of the protein and facilitate the development of an in vitro transposition system. ..
- CONJUGATION AND RECOMBINATION IN MYCOBACTERIAKEITH DERBYSHIRE; Fiscal Year: 2009..2. To identify and characterize trans-acting transfer functions in both donor and recipient cells. 3. To examine transfer of chromosomal and plasmid DNA among fast- and slow-growing mycobacteria. ..
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