Yersinia pestis

Summary

Alias: "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900, "Bacterium pestis" Lehmann and Neumann 1896, "Pasteurella pestis" (Lehmann and Neumann 1896) Bergey et al. 1923, "Pestisella pestis" (Lehmann and Neumann 1896) Dorofeev 1947, Bacillus pestis, Bacterium pestis, Pasteurella pestis, Pestisella pestis, Yersinia pestis (Lehmann and Neumann 1896) van Loghem 1944 (Approved Lists 1980), nom. cons, Yersinia pseudotuberculosis subsp. pestis, Yersinia pseudotuberculosis subsp. pestis (Lehmann and Neumann 1896) Bercovier et al. 1981

Top Publications

  1. pmc Caspase-1 activation in macrophages infected with Yersinia pestis KIM requires the type III secretion system effector YopJ
    Sarit Lilo
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, State University of New York at Stony Brook, New York 11794 5222, USA
    Infect Immun 76:3911-23. 2008
  2. pmc YopK controls both rate and fidelity of Yop translocation
    Rebecca Dewoody
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Mol Microbiol 87:301-17. 2013
  3. ncbi DNA assays for detection, identification, and individualization of select agent microorganisms
    Susan W Jones
    Armed Forces Institute of Pathology, Department of Microbiology, 6825 16th Street NW, Washington, DC 20306, USA
    Croat Med J 46:522-9. 2005
  4. pmc A tandem repeats database for bacterial genomes: application to the genotyping of Yersinia pestis and Bacillus anthracis
    P Le Fleche
    Centre d Etudes du Bouchet, BP3, 91710 Vert le Petit, France
    BMC Microbiol 1:2. 2001
  5. pmc Protective immunity against a lethal respiratory Yersinia pestis challenge induced by V antigen or the F1 capsular antigen incorporated into adenovirus capsid
    Julie L Boyer
    Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10026, USA
    Hum Gene Ther 21:891-901. 2010
  6. doi Identification of Yersinia pestis and Escherichia coli strains by whole cell and outer membrane protein extracts with mass spectrometry-based proteomics
    Rabih E Jabbour
    SAIC, Aberdeen Proving Ground, Maryland 21010, US Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010 5424, USA
    J Proteome Res 9:3647-55. 2010
  7. ncbi HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis
    H A Jones
    University of Kentucky, Department of Microbiology and Immunology, Lexington 40536 0084, USA
    Microbiology 145:2117-28. 1999
  8. ncbi Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b
    M Skurnik
    Department of Medical Biochemistry, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Mol Microbiol 37:316-30. 2000
  9. ncbi [Study on the situation of plague in Junggar Basin of China]
    Yu Jiang Zhang
    The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830002, China
    Zhonghua Liu Xing Bing Xue Za Zhi 29:136-44. 2008
  10. doi Attenuated enzootic (pestoides) isolates of Yersinia pestis express active aspartase
    Scott W Bearden
    Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, Bacterial Diseases Branch, Fort Collins, CO 80521, USA
    Microbiology 155:198-209. 2009

Research Grants

  1. Vincent A Fischetti; Fiscal Year: 2014
  2. JOSEPH THOMAS WADE; Fiscal Year: 2015
  3. Plague biofilm formation--regulation and function
    ROBERT DONALD PERRY; Fiscal Year: 2013
  4. Cell-mediated protection against pneumonic plague
    Jr Shiuan Lin; Fiscal Year: 2013
  5. Evaluation of Ail as a protective immunogen for plague
    Eric S Krukonis; Fiscal Year: 2012
  6. Role of Yersinia pestis Ail in Yop delivery and plague
    Eric S Krukonis; Fiscal Year: 2012
  7. Igor E Brodsky; Fiscal Year: 2016
  8. Wyndham W Lathem; Fiscal Year: 2014
  9. Multivalent Plague, Anthrax Vaccines Using Bacteriophage T4 Display
    Venigalla B Rao; Fiscal Year: 2013
  10. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010

Patents

  1. COMPOSITIONS AND METHODS
  2. METHODS AND MATERIALS FOR ENCAPSULATING PROTEINS
  3. COMPOSITIONS AND METHODS FOR BACTERIAL DELIVERY OF POLYPEPTIDES
  4. NETWORK-BASED MICROBIAL COMPOSITIONS AND METHODS
  5. COMPOSITIONS AND METHODS FOR BACTERIAL DELIVERY OF POLYPEPTIDES
  6. COMPOSITIONS AND METHODS FOR INHIBITION OF PATHOGENIC BACTERIAL GROWTH
  7. BROAD SPECTRUM ANTIBIOTIC ARYLOMYCIN ANALOGS
  8. Nucleic acid probe-based diagnostic assays for prokaryotic and eukaryotic organisms
  9. BROAD SPECTRUM ANTIBIOTIC ARYLOMYCIN ANALOGS
  10. COMPOSITIONS AND METHODS

Detail Information

Publications312 found, 100 shown here

  1. pmc Caspase-1 activation in macrophages infected with Yersinia pestis KIM requires the type III secretion system effector YopJ
    Sarit Lilo
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, State University of New York at Stony Brook, New York 11794 5222, USA
    Infect Immun 76:3911-23. 2008
    ..Naïve murine macrophages were infected with a panel of different Yersinia pestis and Yersinia pseudotuberculosis strains to determine whether Yops of these species inhibit caspase-1 ..
  2. pmc YopK controls both rate and fidelity of Yop translocation
    Rebecca Dewoody
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Mol Microbiol 87:301-17. 2013
    b>Yersinia pestis, the causative agent of plague, utilizes a type III secretion system (T3SS) to intoxicate host cells...
  3. ncbi DNA assays for detection, identification, and individualization of select agent microorganisms
    Susan W Jones
    Armed Forces Institute of Pathology, Department of Microbiology, 6825 16th Street NW, Washington, DC 20306, USA
    Croat Med J 46:522-9. 2005
    ..the status of DNA assays used for the detection, identification, and individualization of Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia mallei, and Brucella abortus...
  4. pmc A tandem repeats database for bacterial genomes: application to the genotyping of Yersinia pestis and Bacillus anthracis
    P Le Fleche
    Centre d Etudes du Bouchet, BP3, 91710 Vert le Petit, France
    BMC Microbiol 1:2. 2001
    ..The availability of whole-genome sequences has opened the way to the systematic evaluation of tandem repeats diversity and application to epidemiological studies...
  5. pmc Protective immunity against a lethal respiratory Yersinia pestis challenge induced by V antigen or the F1 capsular antigen incorporated into adenovirus capsid
    Julie L Boyer
    Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10026, USA
    Hum Gene Ther 21:891-901. 2010
    The aerosol form of the bacterium Yersinia pestis causes pneumonic plague, a rapidly fatal disease that is a biothreat if deliberately released...
  6. doi Identification of Yersinia pestis and Escherichia coli strains by whole cell and outer membrane protein extracts with mass spectrometry-based proteomics
    Rabih E Jabbour
    SAIC, Aberdeen Proving Ground, Maryland 21010, US Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland 21010 5424, USA
    J Proteome Res 9:3647-55. 2010
    ..These extracts were isolated from pathogenic and nonpathogenic strains of Yersinia pestis and Escherichia coli using ultracentrifugation and a sarkosyl extraction method followed by protein digestion ..
  7. ncbi HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis
    H A Jones
    University of Kentucky, Department of Microbiology and Immunology, Lexington 40536 0084, USA
    Microbiology 145:2117-28. 1999
    The haemin storage (Hms) phenotype of Yersinia pestis has been shown to be involved in the blockage of fleas that is required for the transmission of plague from fleas to mammals...
  8. ncbi Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b
    M Skurnik
    Department of Medical Biochemistry, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Mol Microbiol 37:316-30. 2000
    One of the most virulent and feared bacterial pathogens is Yersinia pestis, the aetiologic agent of bubonic plague...
  9. ncbi [Study on the situation of plague in Junggar Basin of China]
    Yu Jiang Zhang
    The Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830002, China
    Zhonghua Liu Xing Bing Xue Za Zhi 29:136-44. 2008
    ..To understand the distribution, fauna, population structure of host animals and their parasitic fleas as well as popular dynamic of animal plague of natural plague foci in Junggar Basin...
  10. doi Attenuated enzootic (pestoides) isolates of Yersinia pestis express active aspartase
    Scott W Bearden
    Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, Bacterial Diseases Branch, Fort Collins, CO 80521, USA
    Microbiology 155:198-209. 2009
    It is established that Yersinia pestis, the causative agent of bubonic plague, recently evolved from enteropathogenic Yersinia pseudotuberculosis by undergoing chromosomal degeneration while acquiring two unique plasmids that facilitate ..
  11. pmc Influence of Na(+), dicarboxylic amino acids, and pH in modulating the low-calcium response of Yersinia pestis
    Robert R Brubaker
    Department of Microbiology and Molecular Genetics, 2209 Biophysical Medical Sciences Building, Michigan State University, East Lansing, MI 48824, USA
    Infect Immun 73:4743-52. 2005
    The virulence of yersiniae is promoted in part by shared approximately 70-kb plasmids (pCD in Yersinia pestis and pYV in enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica) that mediate a low-calcium response...
  12. pmc Yersinia pestis endowed with increased cytotoxicity is avirulent in a bubonic plague model and induces rapid protection against pneumonic plague
    Ayelet Zauberman
    Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness Ziona, Israel
    PLoS ONE 4:e5938. 2009
    ..Previous observations have indicated that Yersinia pestis, the causative agent of plague disease, exhibits restricted capacity to induce cell death in macrophages due ..
  13. pmc Correlates of environmental factors and human plague: an ecological study in Vietnam
    Hau V Pham
    Institute of Hygiene and Epidemiology of Tay Nguyen, Dak Lak, Vietnam
    Int J Epidemiol 38:1634-41. 2009
    Human plague caused by Yersinia pestis remains a public health threat in endemic countries, because the disease is associated with increased risk of mortality and severe economic and social consequences...
  14. pmc Human anti-plague monoclonal antibodies protect mice from Yersinia pestis in a bubonic plague model
    Xiaodong Xiao
    Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute Frederick, National Institutes of Health, Frederick, Maryland, United States of America
    PLoS ONE 5:e13047. 2010
    b>Yersinia pestis is the etiologic agent of plague that has killed more than 200 million people throughout the recorded history of mankind...
  15. pmc Immunization of mice with YscF provides protection from Yersinia pestis infections
    Jyl S Matson
    Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202, USA
    BMC Microbiol 5:38. 2005
    b>Yersinia pestis, the causative agent of plague, is a pathogen with a tremendous ability to cause harm and panic in populations...
  16. ncbi Antigenic profiling of yersinia pestis infection in the Wyoming coyote (Canis latrans)
    G Vernati
    Department of Veterinary Sciences, University of Wyoming, Laramie, Wyoming 82070, USA
    J Wildl Dis 47:21-9. 2011
    Although Yersinia pestis is classified as a "high-virulence" pathogen, some host species are variably susceptible to disease...
  17. ncbi Inactivation of Yersinia pseudotuberculosis, as a surrogate for Yersinia pestis, by liquid biocides in the presence of food residue
    J Hilgren
    Escola Research, Development, and Engineering, 655 Lone Oak Drive, Eagan, Minnesota 55121, USA
    J Food Prot 72:392-8. 2009
    ..the ability of commercial biocides to inactivate Yersinia pseudotuberculosis ATCC 29910, as a surrogate for Yersinia pestis, in the presence of food residues...
  18. pmc Recent findings regarding maintenance of enzootic variants of Yersinia pestis in sylvatic reservoirs and their significance in the evolution of epidemic plague
    Scott W Bearden
    Division of Vector Borne Infectious Diseases, Bacterial Diseases Branch, Centers for Disease Control and Prevention, Foothills Campus, Fort Collins, Colorado 80521, USA
    Vector Borne Zoonotic Dis 10:85-92. 2010
    ..the widespread presence of bubonic plague in sylvatic reservoirs throughout the world, the causative agent (Yersinia pestis) evolved in its present form within the last 20,000 years from enteropathogenic Yersinia pseudotuberculosis...
  19. pmc Yersinia pestis YopE contains a dominant CD8 T cell epitope that confers protection in a mouse model of pneumonic plague
    Jr Shiuan Lin
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 187:897-904. 2011
    ..The Gram-negative bacterium Yersinia pestis causes pneumonic plague, an acutely lethal septic pneumonia...
  20. pmc Involvement of the post-transcriptional regulator Hfq in Yersinia pestis virulence
    Jing Geng
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    PLoS ONE 4:e6213. 2009
    b>Yersinia pestis is the causative agent of plague, which is transmitted primarily between fleas and mammals and is spread to humans through the bite of an infected flea or contact with afflicted animals...
  21. pmc Delineation and analysis of chromosomal regions specifying Yersinia pestis
    Anne Derbise
    Institut Pasteur, Yersinia Research Unit, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Infect Immun 78:3930-41. 2010
    b>Yersinia pestis, the causative agent of plague, has recently diverged from the less virulent enteropathogen Yersinia pseudotuberculosis...
  22. doi Oropsylla hirsuta (Siphonaptera: Ceratophyllidae) can support plague epizootics in black-tailed prairie dogs (Cynomys ludovicianus) by early-phase transmission of Yersinia pestis
    Aryn P Wilder
    Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
    Vector Borne Zoonotic Dis 8:359-67. 2008
    Plague, caused by the bacterium Yersinia pestis, often leads to rapid decimation of black-tailed prairie dog colonies. Flea-borne transmission of Y...
  23. pmc Yersinia pestis YopJ suppresses tumor necrosis factor alpha induction and contributes to apoptosis of immune cells in the lymph node but is not required for virulence in a rat model of bubonic plague
    Nadine Lemaitre
    Rocky Mountain Laboratories, NIAID NIH, 903 S 4th St, Hamilton, MT 59840, USA
    Infect Immun 74:5126-31. 2006
    ..We evaluated the role of Yersinia pestis YopJ in a rat model of bubonic plague following intradermal infection with a fully virulent Y...
  24. pmc High-frequency RecA-dependent and -independent mechanisms of Congo red binding mutations in Yersinia pestis
    J M Hare
    Department of Biomedical Sciences, University at Albany, State University of New York, USA
    J Bacteriol 181:4896-904. 1999
    b>Yersinia pestis, which causes bubonic and pneumonic plague, forms pigmented red colonies on Congo red (CR) dye agar...
  25. pmc The cyclic AMP receptor protein, CRP, is required for both virulence and expression of the minimal CRP regulon in Yersinia pestis biovar microtus
    Lingjun Zhan
    Institute of Laboratory Animal Sciences, Chinese Academy of Medicine Peking Union Medical College, Beijing 100021, China
    Infect Immun 76:5028-37. 2008
    ..In the present study, a null deletion of the crp gene was constructed for Yersinia pestis bv. microtus strain 201. Microarray expression analysis disclosed that at least 6% of Y...
  26. ncbi Estimation of vector infectivity rates for plague by means of a standard curve-based competitive polymerase chain reaction method to quantify Yersinia pestis in fleas
    B J Hinnebusch
    Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Am J Trop Med Hyg 58:562-9. 1998
    ..In the case of bubonic plague, infective flea vectors contain large numbers of Yersinia pestis within a bacterial mass that blocks the flea's foregut, and only such blocked fleas are important for ..
  27. doi The effects of low-shear mechanical stress on Yersinia pestis virulence
    Abidat Lawal
    Department of Biology, Texas Southern University, Houston, Texas 77004, USA
    Astrobiology 10:881-8. 2010
    ..b>Yersinia pestis (YP) causes bubonic, septicemic, and pneumonic plague and is capable of killing infected patients within 3-7 ..
  28. pmc Molecular identification by "suicide PCR" of Yersinia pestis as the agent of medieval black death
    D Raoult
    Centre National de la Recherche Scientifique Unité Propre de Recherche de l Enseignement Superieur UPRES A 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille, France
    Proc Natl Acad Sci U S A 97:12800-3. 2000
    ..the causative organism was debated because no definitive evidence has been obtained to confirm the role of Yersinia pestis as the agent of plague...
  29. doi Cell-mediated immune response and Th/Th cytokine profile of B-T constructs of F1 and V antigen of Yersinia pestis
    G Gupta
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Scand J Immunol 71:186-98. 2010
    b>Yersinia pestis, a Gram-negative bacterium, is the etiological agent of pneumonic and bubonic plague and still active in various regions of the world...
  30. ncbi Temporal dynamics of early-phase transmission of Yersinia pestis by unblocked fleas: secondary infectious feeds prolong efficient transmission by Oropsylla montana (Siphonaptera: Ceratophyllidae)
    Rebecca J Eisen
    Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
    J Med Entomol 44:672-7. 2007
    ..A recent study of Oropsylla montana (Baker) (Siphonaptera: Ceratophyllidae), the primary vector of Yersinia pestis (Yersin) to humans in North America, revealed that this flea feeds readily on a daily basis, has a very short ..
  31. ncbi A new asset for pathogen informatics--the Enteropathogen Resource Integration Center (ERIC), an NIAID Bioinformatics Resource Center for Biodefense and Emerging/Re-emerging Infectious Disease
    John M Greene
    Health Research Systems, SRA International, Inc, Rockville, MD, USA
    Adv Exp Med Biol 603:28-42. 2007
    ..ERIC serves as a comprehensive information resource for five related pathogens: Yersinia enterocolitica, Yersinia pestis, diarrheagenic E. coli, Shigella spp., and Salmonella spp...
  32. doi In silico comparison of Yersinia pestis and Yersinia pseudotuberculosis transcriptomes reveals a higher expression level of crucial virulence determinants in the plague bacillus
    Sylvie Chauvaux
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Int J Med Microbiol 301:105-16. 2011
    Although Yersinia pestis and Yersinia pseudotuberculosis are genetically very similar (97% nucleotide sequence identity for most of the chromosomal genes), they exhibit very different patterns of infection. Y...
  33. ncbi Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis
    Stanislav Forman
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    Microbiology 153:2332-41. 2007
    b>Yersinia pestis genomes contain genes homologous to the aerobactin receptor (iutA) and biosynthetic genes (iucABCD) as well as the ferric hydroxamate uptake system (fhuCDB) of Escherichia coli...
  34. ncbi Genome plasticity in Yersinia pestis
    Lyndsay Radnedge
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, L 441, 7000 East Avenue, Livermore, CA 94550, USA
    Microbiology 148:1687-98. 2002
    b>Yersinia pestis, the causative agent of bubonic plague, emerged recently (<20000 years ago) as a clone of Yersinia pseudotuberculosis. There is scant evidence of genome diversity in Y...
  35. ncbi Using every trick in the book: the Pla surface protease of Yersinia pestis
    Marjo Suomalainen
    Faculty of Biosciences, General Microbiology, University of Helsinki, Finland
    Adv Exp Med Biol 603:268-78. 2007
    The Pla surface protease of Yersinia pestis, encoded by the Y. pestis-specific plasmid pPCP1, is a versatile virulence factor...
  36. ncbi Early-phase transmission of Yersinia pestis by cat fleas (Ctenocephalides felis) and their potential role as vectors in a plague-endemic region of Uganda
    Rebecca J Eisen
    Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Enteric and Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Am J Trop Med Hyg 78:949-56. 2008
    In recent decades, the majority of human plague cases (caused by Yersinia pestis) have been reported from Africa...
  37. doi The role of the phoPQ operon in the pathogenesis of the fully virulent CO92 strain of Yersinia pestis and the IP32953 strain of Yersinia pseudotuberculosis
    Joel Bozue
    Bacteriology Division, The United States Army of Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, United States
    Microb Pathog 50:314-21. 2011
    At the genomic level, Yersinia pestis and Yersinia pseudotuberculosis are nearly identical but cause very different diseases. Y. pestis is the etiologic agent of plague; whereas Y...
  38. pmc mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homolog of the low-calcium-response protein, LcrD, of Yersinia pestis
    G P Andrews
    Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799
    Infect Immun 60:3287-95. 1992
    ..be highly homologous (68%) to the sequence of the protein encoded by the low-calcium-response locus, lcrD, of Yersinia pestis. The lcrD encodes an inner membrane regulatory protein that has an N-terminal membrane anchor and that is ..
  39. pmc Silencing and reactivation of urease in Yersinia pestis is determined by one G residue at a specific position in the ureD gene
    F Sebbane
    Equipe Inserm E9919 Université JE2225, Département de Pathogenèse des Maladies Infectieuses et Parasitaires, Institut de Biologie de Lille, 59021 Lille, France
    Infect Immun 69:170-6. 2001
    b>Yersinia pestis, the plague agent, is a naturally nonureolytic microorganism, while all other Yersinia species display a potent urease activity. In this report we demonstrate that Y...
  40. ncbi Determination of the virulence of the pigmentation-deficient and pigmentation-/plasminogen activator-deficient strains of Yersinia pestis in non-human primate and mouse models of pneumonic plague
    S Welkos
    Division of Bacteriology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Vaccine 20:2206-14. 2002
    The current human plague vaccine, a killed Yersinia pestis whole-cell preparation, does not protect against aerosol challenge and is reactogenic and antigenically undefined. Live attenuated Y...
  41. ncbi Expression of heterologous O-antigen in Yersinia pestis KIM does not affect virulence by the intravenous route
    P C F Oyston
    Microbiology, Dstl, CBS Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    J Med Microbiol 52:289-94. 2003
    All strains of Yersinia pestis examined have been found to lack an O-antigen. In other members of the Enterobacteriaceae, the rough phenotype often results in attenuation. However, Y. pestis is the aetiological agent of bubonic plague...
  42. pmc Early-phase transmission of Yersinia pestis by unblocked fleas as a mechanism explaining rapidly spreading plague epizootics
    Rebecca J Eisen
    Bacterial Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, CO 80522, USA
    Proc Natl Acad Sci U S A 103:15380-5. 2006
    ..Worldwide, it remains a threat to humans and is a potential agent of bioterrorism. Dissemination of Yersinia pestis, the etiological agent of plague, by blocked fleas has been the accepted paradigm for flea-borne transmission...
  43. ncbi Phenotypic and molecular characterizations of Yersinia pestis isolates from Kazakhstan and adjacent regions
    Jennifer L Lowell
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3500 Rampart Rd, Fort Collins, CO 80522, USA
    Microbiology 153:169-77. 2007
    ..b>Yersinia pestis, the aetiological agent of plague, has been well defined genotypically on local and worldwide scales using ..
  44. pmc A surface-focused biotinylation procedure identifies the Yersinia pestis catalase KatY as a membrane-associated but non-surface-located protein
    Tanya Myers-Morales
    Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40536 0298, USA
    Appl Environ Microbiol 73:5750-9. 2007
    This study identified major surface proteins of the plague bacterium Yersinia pestis. We applied a novel surface biotinylation method, followed by NeutrAvidin (NA) bead capture, on-bead digestion, and identification by liquid ..
  45. ncbi High throughput screening for small-molecule inhibitors of type III secretion in Yersinia pestis
    Ning Pan
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, USA
    Adv Exp Med Biol 603:367-75. 2007
    b>Yersinia pestis, Yersinia pseudotuberculosis and Yersinia enterocolitica, utilize a plasmid encoded type III secretion system (T3SS) to promote infection by delivering Yersinia outer proteins (Yops) into the cytosol of mammalian cells...
  46. pmc A nasal interleukin-12 DNA vaccine coexpressing Yersinia pestis F1-V fusion protein confers protection against pneumonic plague
    Hitoki Yamanaka
    Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59717 3610, USA
    Infect Immun 76:4564-73. 2008
    ..Since possible exposure to plague is via Yersinia pestis-laden aerosols that results in pneumonic plague, arming both the mucosal and systemic immune systems may ..
  47. pmc Development and evaluation of two simple, rapid immunochromatographic tests for the detection of Yersinia pestis antibodies in humans and reservoirs
    Minoarisoa Rajerison
    Unité Peste Institut Pasteur de Madagascar, Antananarivo, Madagascar
    PLoS Negl Trop Dis 3:e421. 2009
    ..b>Yersinia pestis isolation for confirmation is time-consuming and difficult to perform under field conditions...
  48. pmc Purification and characterization of Yersinia enterocolitica and Yersinia pestis LcrV-cholera toxin A(2)/B chimeras
    Juliette K Tinker
    Department of Biological Sciences, Boise State University, Boise, ID 83725, USA
    Protein Expr Purif 74:16-23. 2010
    b>Yersinia pestis is a virulent human pathogen and potential biological weapon. Despite a long history of research on this organism, there is no licensed vaccine to protect against pneumonic forms of Y. pestis disease...
  49. pmc Protection Afforded by Fluoroquinolones in Animal Models of Respiratory Infections with Bacillus anthracis, Yersinia pestis, and Francisella tularensis
    Johnny W Peterson
    Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd Galveston, Texas 77555 0610
    Open Microbiol J 4:34-46. 2010
    ..Bacillus anthracis Ames, Yersinia pestis CO92, and Francisella tularensis SCHU S4 have equivalent susceptibility in vitro to ciprofloxacin and ..
  50. pmc Novel genetic tools for diaminopimelic acid selection in virulence studies of Yersinia pestis
    David M Bland
    Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, United States of America
    PLoS ONE 6:e17352. 2011
    ..For highly pathogenic bacteria, such as Yersinia pestis, these studies are currently limited because deliberate introduction of antibiotic resistance is restricted ..
  51. pmc The Psa fimbriae of Yersinia pestis interact with phosphatidylcholine on alveolar epithelial cells and pulmonary surfactant
    Estela M Galván
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce St, Philadelphia, PA 19104, USA
    Infect Immun 75:1272-9. 2007
    The pH 6 antigen (Psa) of Yersinia pestis consists of fimbriae with adhesive properties of potential importance for the pathogenesis of plague, including pneumonic plague...
  52. pmc The single substitution I259T, conserved in the plasminogen activator Pla of pandemic Yersinia pestis branches, enhances fibrinolytic activity
    Johanna Haiko
    General Microbiology, Faculty of Biosciences, FI 00014 University of Helsinki, Finland
    J Bacteriol 191:4758-66. 2009
    The outer membrane plasminogen activator Pla of Yersinia pestis is a central virulence factor in plague. The primary structure of the Pla beta-barrel is conserved in Y...
  53. pmc Complete DNA sequence and detailed analysis of the Yersinia pestis KIM5 plasmid encoding murine toxin and capsular antigen
    L E Lindler
    Department of Bacterial Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Washington, D C 20307 5100, USA
    Infect Immun 66:5731-42. 1998
    b>Yersinia pestis, the causative agent of plague, harbors at least three plasmids necessary for full virulence of the organism, two of which are species specific. One of the Y...
  54. pmc Direct transcriptional control of the plasminogen activator gene of Yersinia pestis by the cyclic AMP receptor protein
    Tae Jong Kim
    Department of Food Science and Technology, University of California, Davis, CA 95616, USA
    J Bacteriol 189:8890-900. 2007
    ..A key event in the evolution of the highly virulent plague bacterium Yersinia pestis was the acquisition of plasmid pPCP1, which carries the plasminogen activator gene, pla...
  55. ncbi Prevalence of Yersinia pestis in rodents and fleas associated with black-tailed prairie dogs (Cynomys ludovicianus) at Thunder Basin National Grassland, Wyoming
    Bala Thiagarajan
    Division of Biology, 232 Ackert Hall, Kansas State University, Manhattan, Kansas 66506, USA
    J Wildl Dis 44:731-6. 2008
    ..associated with prairie dogs are considered important for the maintenance and transmission of the bacterium (Yersinia pestis) that causes plague...
  56. pmc Fine-tuning synthesis of Yersinia pestis LcrV from runaway-like replication balanced-lethal plasmid in a Salmonella enterica serovar typhimurium vaccine induces protection against a lethal Y. pestis challenge in mice
    Ascención Torres-Escobar
    Center for Infectious Diseases and Vaccinology at Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, Arizona 85287 5401, USA
    Infect Immun 78:2529-43. 2010
    ..To validate these vector attributes, the Yersinia pestis virulence antigen LcrV was used to develop a vaccine against plague...
  57. ncbi Temperature-dependent regulation of Yersinia enterocolitica Class III flagellar genes
    V Kapatral
    Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow 83843, USA
    Mol Microbiol 19:1061-71. 1996
    ..a key environmental cue for Yersinia enterocolitica as well as for the two other closely related pathogens, Yersinia pestis and Yersinia pseudotuberculosis. Between the range of 30 degrees C and 37 degrees C, Y...
  58. ncbi An outbreak of plague including cases with probable pneumonic infection, Ecuador, 1998
    J M Gabastou
    PAHO WHO, Quito, Ecuador
    Trans R Soc Trop Med Hyg 94:387-91. 2000
    ..Blood samples from humans, dogs, and a rodent were tested for antibody to the F1 antigen of Yersinia pestis by passive haemagglutination assay...
  59. ncbi Immunogeneity and structural organisation of some pLCR-encoded proteins of Yersinia pestis
    V A Feodorova
    Laboratory of Hybridomas, Russia State Antiplague Research Institute Microbe, Saratov
    J Med Microbiol 50:13-22. 2001
    A novel method of cultivation of Yersinia pestis EV-76 and its isogenic strains KM-217 (pPst-;pCad+;pFra-) and KM-218 (pPst-;pCad-;pFra-) and careful extraction of Y...
  60. pmc Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression
    Andreas Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, Germany
    J Exp Med 196:1017-24. 2002
    A characteristic of the three human-pathogenic Yersinia spp. (the plague agent Yersinia pestis and the enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica) is the expression of the virulence (V)-antigen (LcrV)...
  61. ncbi Yersinia pestis and plague
    R W Titball
    Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
    Biochem Soc Trans 31:104-7. 2003
    b>Yersinia pestis is the aetiological agent of plague, a disease of humans that has potentially devastating consequences. Evidence indicates that Y...
  62. ncbi Oligodendrocyte myelin glycoprotein growth inhibition function requires its conserved leucine-rich repeat domain, not its glycosylphosphatidyl-inositol anchor
    Patrick Vourc'h
    Dynamique et pathologie du développement cérébral, INSERM U 316, 2 bis, boulevard Tonnelle, 37032 Tours Cedex, France
    J Neurochem 85:889-97. 2003
    ..The possible three-dimensional structure of the LRR domain of OMgp was modelled using the structure of Yersinia pestis YopM cytotoxin as a template...
  63. ncbi Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague
    Fubo Liang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Biol Chem 278:41734-41. 2003
    ..There is increasing risk of misuse of infectious agents, such as Yersinia pestis, as weapons of terror as well as instruments of warfare for mass destruction...
  64. ncbi Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH
    Andres Alonso
    Program of Signal Transduction, Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 279:4922-8. 2004
    A key virulence factor for Yersinia pestis, the etiologic agent of plague, is the tyrosine phosphatase YopH, which the bacterium injects into host cells...
  65. pmc The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase
    Christopher T Eggers
    Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143 92280, USA
    Biochem J 379:107-18. 2004
    ..Recombinant protein was expressed and purified from E. coli, Yersinia pestis and Pseudomonas aeruginosa, all species that encounter the mammalian immune system, and also from the plant ..
  66. pmc Identifying sources of human exposure to plague
    Jennifer L Lowell
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, 3500 Rampart Rd, Fort Collins, CO 80522, USA
    J Clin Microbiol 43:650-6. 2005
    b>Yersinia pestis, the etiologic agent of plague, has shaped the course of human history, killing millions of people in three major pandemics...
  67. ncbi Simultaneous measurement of specific serum IgG responses to five select agents
    R E Biagini
    Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    Anal Bioanal Chem 382:1027-34. 2005
    ..A subset of these agents includes Bacillus anthracis, Yersinia pestis, Francisella tularensis, ricin toxin (RT), and staphylococcal enterotoxin B (SEB)...
  68. pmc Serotype differences and lack of biofilm formation characterize Yersinia pseudotuberculosis infection of the Xenopsylla cheopis flea vector of Yersinia pestis
    David L Erickson
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, 903 South 4th St, Hamilton, MT 59840, USA
    J Bacteriol 188:1113-9. 2006
    b>Yersinia pestis, the agent of plague, is usually transmitted by fleas. To produce a transmissible infection, Y. pestis colonizes the flea midgut and forms a biofilm in the proventricular valve, which blocks normal blood feeding...
  69. pmc Epizootiologic parameters for plague in Kazakhstan
    Michael Begon
    University of Liverpool, Liverpool, United Kingdom
    Emerg Infect Dis 12:268-73. 2006
    Reliable estimates are lacking of key epizootiologic parameters for plague caused by Yersinia pestis infection in its natural reservoirs...
  70. pmc Effects of Psa and F1 on the adhesive and invasive interactions of Yersinia pestis with human respiratory tract epithelial cells
    Fengzhi Liu
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Infect Immun 74:5636-44. 2006
    b>Yersinia pestis, the causative agent of plague, expresses the Psa fimbriae (pH 6 antigen) in vitro and in vivo...
  71. pmc Development of in vitro correlate assays of immunity to infection with Yersinia pestis
    J Bashaw
    Bacteriology Division, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA
    Clin Vaccine Immunol 14:605-16. 2007
    ..The F1 capsule antigen stimulates a protective immune response to most strains of Yersinia pestis. However, strains of Y...
  72. ncbi Human plague in the southwestern United States, 1957-2004: spatial models of elevated risk of human exposure to Yersinia pestis
    Rebecca J Eisen
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, P O Box 2087, Fort Collins, CO 80522, USA
    J Med Entomol 44:530-7. 2007
    Plague is a rare but highly virulent flea-borne zoonotic disease caused by the Gram-negative bacterium Yersinia pestis Yersin...
  73. ncbi A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs
    V A Feodorova
    Russian State Anti Plague Research Institute Microbe, 46 Universitetskaya Street, Saratov 410005, Russia
    Vaccine 25:7620-8. 2007
    The lpxM mutant of the live vaccine Yersinia pestis EV NIIEG strain synthesising a less toxic penta-acylated lipopolysaccharide was found to be avirulent in mice and guinea pigs, notably showing no measurable virulence in Balb/c mice ..
  74. ncbi Functional quorum sensing systems affect biofilm formation and protein expression in Yersinia pestis
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, USA
    Adv Exp Med Biol 603:178-91. 2007
    ..Two-dimensional gel electrophoresis revealed altered levels of protein expression in a Y. pestis triple QS mutant at 26 degrees C and 37 degrees C...
  75. ncbi Regulation of biofilm formation in Yersinia pestis
    Alexander G Bobrov
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, USA
    Adv Exp Med Biol 603:201-10. 2007
    ..Finally, protein-protein interactions and the cytoplasmic location of the enzymatic domains of HmsT and HmsP are evaluated...
  76. doi Uniquely insidious: Yersinia pestis biofilms
    Creg Darby
    Department of Cell and Tissue Biology, University of California, San Francisco, Box 0640 Room C 734, San Francisco, CA 94143 0640, USA
    Trends Microbiol 16:158-64. 2008
    Bubonic plague, one of history's deadliest infections, is transmitted by fleas infected with Yersinia pestis. The bacteria can starve fleas by blocking their digestive tracts, which stimulates the insects to bite repeatedly and thereby ..
  77. doi A missense mutation causes aspartase deficiency in Yersinia pestis
    Ronald E Viola
    Department of Chemistry, University of Toledo, 2801 W Bancroft Street, Toledo, OH 43606, USA
    Microbiology 154:1271-80. 2008
    It is established that cells of Yersinia pestis, the causative agent of bubonic plague, excrete l-aspartic acid at the expense of exogenous l-glutamic acid during expression of the low-calcium response...
  78. pmc Experimental evidence for negative selection in the evolution of a Yersinia pestis pseudogene
    Yi Cheng Sun
    Program in Microbial Pathogenesis, Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:8097-101. 2008
    b>Yersinia pestis, the agent of bubonic plague, evolved from the enteric pathogen Yersinia pseudotuberculosis within the past 20,000 years...
  79. pmc Single-dose, virus-vectored vaccine protection against Yersinia pestis challenge: CD4+ cells are required at the time of challenge for optimal protection
    Anasuya Chattopadhyay
    Department of Pathology, Yale University School of Medicine, 310 Cedar Street LH 315, New Haven, CT 06510, USA
    Vaccine 26:6329-37. 2008
    ..recombinant vesicular stomatitis virus (VSV) vectored plague vaccine expressing a secreted form of Yersinia pestis low calcium response protein V (LcrV) from the first position of the VSV genome...
  80. doi Characterization of the rat pneumonic plague model: infection kinetics following aerosolization of Yersinia pestis CO92
    Stacy L Agar
    Departments of Microbiology and Immunology, UTMB, 301 University Boulevard, MRB 3 142H, Galveston, TX 77555 1070, USA
    Microbes Infect 11:205-14. 2009
    b>Yersinia pestis, the causative agent of human bubonic and pneumonic plague, is spread during natural infection by the fleas of rodents...
  81. pmc Analysis of HmsH and its role in plague biofilm formation
    Arwa Abu Khweek
    Department of Microbiology, University of Kentucky, 800 Rose St, Lexington, KY, USA
    Microbiology 156:1424-38. 2010
    The Yersinia pestis Hms(+) phenotype is a manifestation of biofilm formation that causes adsorption of Congo red and haemin at 26 degrees C but not at 37 degrees C...
  82. pmc Yersinia enterocolitica infection and tcaA-dependent killing of Caenorhabditis elegans
    Britta Spanier
    Zentralinstitut für Ernährungs und Lebensmittelforschung, Abteilung Mikrobiologie, Technische Universitat Munchen, 85354 Freising, Germany
    Appl Environ Microbiol 76:6277-85. 2010
    ..The killing by Yersinia enterocolitica requires viable bacteria and, in contrast to that by Yersinia pestis and Yersinia pseudotuberculosis strains, is biofilm independent...
  83. pmc YopK regulates the Yersinia pestis type III secretion system from within host cells
    Rebecca Dewoody
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Mol Microbiol 79:1445-61. 2011
    ..These results suggest a novel role for YopK in controlling the Yersinia type III secretion system...
  84. pmc Tn5AraOut mutagenesis for the identification of Yersinia pestis genes involved in resistance towards cationic antimicrobial peptides
    Jitao Guo
    Department of Microbiology, Peking University Health Science Center, Beijing 100191, China
    Microb Pathog 51:121-32. 2011
    ..To identify Yersinia pestis genes involved in CAMP resistance, libraries of DSY101 (KIM6 caf1 pla psa) minitransposon Tn5AraOut mutants ..
  85. pmc Lack of antimicrobial resistance in Yersinia pestis isolates from 17 countries in the Americas, Africa, and Asia
    Sandra K Urich
    Bacterial Diseases Branch, Division of Vector Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    Antimicrob Agents Chemother 56:555-8. 2012
    b>Yersinia pestis is the causative agent of plague, a fulminant disease that is often fatal without antimicrobial treatment. Plasmid (IncA/C)-mediated multidrug resistance in Y...
  86. pmc Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence
    Ida M Lister
    Center of Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts, USA
    Antimicrob Agents Chemother 56:1120-3. 2012
    ..We report that deletion of the Yersinia pestis AcrAB-TolC homolog leads to increased susceptibility to diverse substrates, including, though unlike in ..
  87. doi Application of nanoparticles for the detection and sorting of pathogenic bacteria by flow-cytometry
    Eran Zahavy
    Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona, Israel
    Adv Exp Med Biol 733:23-36. 2012
    ..the use of q-dots as fluorescence labels for specific conjugates against Bacillus anthracis spores and Yersinia pestis bacteria, which enable the specific detection of the different species...
  88. pmc Characterization of the Na⁺/H⁺ antiporter from Yersinia pestis
    Assaf Ganoth
    Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 6:e26115. 2011
    b>Yersinia pestis, the bacterium that historically accounts for the Black Death epidemics, has nowadays gained new attention as a possible biological warfare agent...
  89. pmc The structure of LsrB from Yersinia pestis complexed with autoinducer-2
    Jeffrey S Kavanaugh
    Microbiology Department, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:1501-5. 2011
    The crystal structure of LsrB from Yersinia pestis complexed with autoinducer-2 (AI-2; space group P2(1)2(1)2(1), unit-cell parameters a = 40.61, b = 61.03, c = 125...
  90. pmc Rational design of pathogen-mimicking amphiphilic materials as nanoadjuvants
    Bret D Ulery
    Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA
    Sci Rep 1:198. 2011
    ..nanovaccines was demonstrated by the induction of long-lived protection against a lethal challenge of Yersinia pestis following a single administration ten months earlier...
  91. doi Intestinal microbial community diversity between healthy and orally infected rabbit with Entamoeba histolytica by ERIC-PCR
    Guang Zhi He
    Guiyang College of Traditional Chinese Medicine, Guiyang, 550002, Guizhou Province, China
    Parasitol Res 111:1123-6. 2012
    ..Shigella flexneri, S. meliloti enterobacterial, Yersinia pestis, Klebsiella pneumoniae subsp., and Escherichia coli. The prominent bacteria had changed after E...
  92. pmc Yersinia pestis intracellular parasitism of macrophages from hosts exhibiting high and low severity of plague
    Duraisamy Ponnusamy
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma, United States of America
    PLoS ONE 7:e42211. 2012
    b>Yersinia pestis causes severe disease in natural rodent hosts, but mild to inapparent disease in certain rodent predators such as dogs. Y...
  93. pmc Yersinia pestis infection and laboratory conditions alter flea-associated bacterial communities
    Ryan T Jones
    Division of Vector borne Disease, Centers for Disease Control and Prevention, Fort Collins, CO, USA
    ISME J 7:224-8. 2013
    ..Oropsylla montana from rock squirrels, Spermophilus varigatus, and infected a subset of collected fleas with Yersinia pestis, the etiological agent of plague...
  94. doi Evolution of a novel lysine decarboxylase in siderophore biosynthesis
    Matthew Burrell
    Institute of Food Research, Colney, Norwich, NR4 7UA, UK
    Mol Microbiol 86:485-99. 2012
    ..We confirmed this by correctly predicting the LDC activity of a DABA DC homologue from a Yersinia pestis siderophore biosynthetic pathway...
  95. pmc Antivirulence genes: insights into pathogen evolution through gene loss
    Kimberly A Bliven
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Infect Immun 80:4061-70. 2012
    ..AVG definition and update the list of known AVGs, which now includes genes from pathogens such as Salmonella, Yersinia pestis, and the virulent Francisella tularensis subspecies...
  96. doi Application of chromosomal DNA and protein targeting for the identification of Yersinia pestis
    Marilynn A Larson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Proteomics Clin Appl 7:416-23. 2013
    ..validated for the identification of pathogens from closely related near neighbors using both chromosomal and protein biomarkers, with emphasis on distinguishing Yersinia pestis from the ancestral bacterium Yersinia pseudotuberculosis.
  97. doi Infrared spectroscopic evidence of a redox-dependent conformational change involving ion binding residue NqrB-D397 in the Na(+)-pumping NADH:quinone oxidoreductase from Vibrio cholerae
    Yashvin Neehaul
    Laboratoire de bioelectrochimie et spectroscopie, UMR 7140, Chimie de la Matière Complexe, Universite de Strasbourg CNRS, Strasbourg, France
    Biochemistry 52:3085-93. 2013
    ..the point of entry of electrons into the respiratory chain in many pathogens, including Vibrio cholerae and Yersinia pestis. In this study, a combined electrochemical and Fourier transform infrared (FTIR) spectroscopic approach ..
  98. pmc Transcriptome analysis of acyl-homoserine lactone-based quorum sensing regulation in Yersinia pestis [corrected]
    Christopher N LaRock
    Department of Microbiology, University of Washington, Seattle, Washington, USA
    PLoS ONE 8:e62337. 2013
    The etiologic agent of bubonic plague, Yersinia pestis, senses self-produced, secreted chemical signals in a process named quorum sensing. Though the closely related enteric pathogen Y...
  99. doi Group-theoretic models of the inversion process in bacterial genomes
    Attila Egri-Nagy
    Centre for Research in Mathematics, University of Western Sydney, Locked Bag 1797, Penrith, NSW, 2751, Australia
    J Math Biol 69:243-65. 2014
    ..We apply the new method to inferring distances and phylogenies for published Yersinia pestis data.
  100. ncbi Persistence of black-tailed prairie-dog populations affected by plague in northern Colorado, USA
    Dylan B George
    Department of Biology, Colorado State University, Campus Delivery 1878, Fort Collins, Colorado 80523, USA
    Ecology 94:1572-83. 2013
    ..responsible for this drastic change in prairie-dog population structure is plague (caused by the bacterium Yersinia pestis)...
  101. pmc Role of Yersinia pestis toxin complex family proteins in resistance to phagocytosis by polymorphonuclear leukocytes
    Justin L Spinner
    Laboratory of Zoonotic Pathogens
    Infect Immun 81:4041-52. 2013
    b>Yersinia pestis carries homologues of the toxin complex (Tc) family proteins, which were first identified in other Gram-negative bacteria as having potent insecticidal activity. The Y...

Research Grants74

  1. Vincent A Fischetti; Fiscal Year: 2014
    ..anthracis virulence, but that of other Category A biological agents with extended soil phases, like Yersinia pestis and Francisella tularensis, which also have extensive environmental phage systems...
  2. JOSEPH THOMAS WADE; Fiscal Year: 2015
    ..the efficacy of these compounds using in vitro and in vivo infection models for Salmonella Typhimurium, a bacterium responsible for millions of infections annually in the US, and Yersinia pestis (plague), a major bioterrorism threat.
  3. Plague biofilm formation--regulation and function
    ROBERT DONALD PERRY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of plague which has caused widespread loss of human life during recurrent pandemics...
  4. Cell-mediated protection against pneumonic plague
    Jr Shiuan Lin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis (Yp) - one of the world's most virulent human pathogens - is the gram-negative bacterium that causes pneumonic plague...
  5. Evaluation of Ail as a protective immunogen for plague
    Eric S Krukonis; Fiscal Year: 2012
    ..We have recently shown that Ail is important for delivery of cytotoxic Yop proteins from Yersinia pestis to phagocytic and non-phagocytic human cells...
  6. Role of Yersinia pestis Ail in Yop delivery and plague
    Eric S Krukonis; Fiscal Year: 2012
    ..We have recently determined that the Yersinia pestis adhesin Ail facilitates T3S of Yersinia outer proteins (Yops) via binding to host fibronectin...
  7. Igor E Brodsky; Fiscal Year: 2016
    ..which expresses many of the same virulence factors as its close relative and plague pathogen Yersinia pestis, as a model to understand the host- pathogen interface and discover shared features of host innate immune ..
  8. Wyndham W Lathem; Fiscal Year: 2014
    ..These alterations may result in genetically related bacteria that are phenotypically quite distinct. Yersinia pestis, responsible for the devastating disease plague, and Yersinia pseudotuberculosis, the causative agent of the ..
  9. Multivalent Plague, Anthrax Vaccines Using Bacteriophage T4 Display
    Venigalla B Rao; Fiscal Year: 2013
    ..plague and multivalent plague-anthrax vaccines that can confer protection against Bacillus anthracis and Yersinia pestis, two Category A biodefense pathogens...
  10. Inhibitors of the Y. pestis cell surface plasminogen activator for biodefense
    Marjorie H Barnes; Fiscal Year: 2010
    b>Yersinia pestis is a Gram-negative bacillus, which is the etiological agent of plague. Human infection by this pathogen may occur by subcutaneous (e.g...
  11. The role of LPS-TLR4 signaling in live vaccine-induced protective responses
    Egil Lien; Fiscal Year: 2013
    ..goal is to define mechanisms for immune protection by Gram-negative bacterial vaccine strains, using novel Yersinia pestis strains as model systems. The gram-negative bacterium Yersinia pestis is the causative agent of plague...
  12. MOLECULAR MECHANISMS OF YERSINIA PESTIS PERSISTENCE IN THE FLEA VECTOR
    Viveka Vadyvaloo; Fiscal Year: 2013
    ..the risk of transmission and human disease, and an enzootic/quiescent stage in which the causative bacterium, Yersinia pestis, persists and maintains the reservoir...
  13. Improved plague vaccine by targeting dendritic cell subsets
    Yoonkyung Do; Fiscal Year: 2010
    Plague caused by the bacterium, Yersinia pestis (Y. pestis) remains an infectious disease of concern to public health due to the absence of a vaccine for humans and the isolation of antibiotic-resistant bacteria. Y...
  14. Yersinia pestis biofilm regulation
    Creg Darby; Fiscal Year: 2010
    ..one of the most virulent of bacterial infections, is spread by the bites of fleas persistently colonized by Yersinia pestis. The bacteria form a biofilm in the digestive tract of the flea that blocks the insect's feeding...
  15. Regulation of Pore Formation by Type III Secretion System
    Gloria I Viboud; Fiscal Year: 2010
    ..well agents causing severe pneumonia, like the opportunistic bacteria Pseudomonas aeruginosa, or the deadly Yersinia pestis. Interestingly, Y...
  16. The Psa fimbriae of Yersinia pestis, an adhesin with protective immunogenic prope
    Dieter M Schifferli; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis is best known as the causative agent of bubonic plague, a disease transmitted by the bite of infected fleas...
  17. Wyndham W Lathem; Fiscal Year: 2015
    ..The Gram-negative bacterium Yersinia pestis causes the disease plague, which can manifest in three distinct forms: bubonic, septicemic, and pneumonic...
  18. DOMINIQUE PASCAL FRUEH; Fiscal Year: 2016
    ..that participates in the synthesis of yersiniabactin (Ybt), a virulence factor found in pathogens such as Yersinia pestis, the causative agent of the bubonic plague, Y. enterocolitica, a food pathogen, and uropathogenic E...
  19. Development, Production and Evaluation of a Multivalent Adenoviral Plague Vaccine
    CHRIS LENTZ; Fiscal Year: 2009
    ..construct and test a multivalent adenoviral vaccine candidate that elicits a potent immune response against Yersinia pestis, the causative agent of plague...
  20. Evaluating the Progression of Pneumonic Plague
    Roger Pechous; Fiscal Year: 2012
    Pneumonic plague results from the inhalation of the bacterium Yersinia pestis. Due to its lethality, rapid disease progression, and ability to be disseminated via aerosolization, Y. pestis is categorized by the U.S...
  21. Genetic and molecular basis of host resistance to Yersinia pestis.
    RICHARD IAN TAPPING; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of bubonic, septicemic and pneumonic plague and represents a serious bioterrorism threat. Most studies on Y...
  22. ROLE OF YAPS IN Y. PESTIS PATHOGENESIS
    Virginia L Miller; Fiscal Year: 2010
    b>Yersinia pestis is a Gram-negative bacterial human pathogen that is the causative agent of plague. Historically Y. pestis has been responsible for significant human morbidity and mortality. However, Y...
  23. Alternative endpoints for plague challenge models
    Richard Frothingham; Fiscal Year: 2005
    b>Yersinia pestis causes human and animal plague. Plague vaccine research has increasing importance since Y. pestis is a potential bioterrorism agent. Published Y. pestis vaccine studies use mortality as the primary endpoint...
  24. Mucosal modified vaccinina Ankara-based plaque vaccines
    DAN STINCHCOMB; Fiscal Year: 2007
    ..In addition, Yersinia pestis, the cause of plague, could be a devastating bioweapon. An intentional release of 50 kg of Y...
  25. A novel ternary virulence system in plague
    Susan C Straley; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of plague in humans...
  26. Regulation of Yersenia pestis virulence genes in response to host cell contact
    Deborah M Anderson; Fiscal Year: 2010
    b>Yersinia pestis translocate virulence factors from the bacterial cytoplasm into host immune cells during infections through the Type III Secretion System (TTSS)...
  27. The Role of LPS and Toll-like Receptors in Plague
    Egil Lien; Fiscal Year: 2010
    The gram-negative bacterium Yersinia pestis is the causative agent of plague. Y...
  28. Virginia L Miller; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of disease in a variety of mammals, and humans can become infected when human and animal ecologies intersect...
  29. Siderophore Biosynthesis Inhibitors as New Antibiotics for Biodefense
    Derek S Tan; Fiscal Year: 2010
    ..of siderophore biosynthesis in two bacteria that are NIAID Priority Pathogens for biodefense research: Yersinia pestis, the causative agent of plague, and Yersinia enterocolitica, a gastroenteritic water- and foodborne pathogen...
  30. Francesca M Marassi; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Yersinia pestis, the causative agent of plague, is a highly pathogenic organism that spreads rapidly and causes extremely high human mortality...
  31. Live attenuated Yersinia as vaccines against pneumonic plague
    Wei Sun; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Yersinia pestis, the etiologic agent of plague, has been responsible for high mortality in several epidemics throughout human history...
  32. YERSINIA PTPASE INHIBITORS AS ANTI-PLAGUE AGENTS
    Zhong Yin Zhang; Fiscal Year: 2003
    b>Yersinia pestis was the pathogen responsible for the bubonic plague, also known as the Black Death...
  33. Arnold Louie; Fiscal Year: 2014
    ..Resistance has also been defined in Select Agents, such as aminoglycoside resistance in Yersinia pestis in Madagascar. Achaogen has developed several series of new aminoglycoside antibiotics (neoglycosides)...
  34. Rapid point-of-care diagnostic for bioterrorism "A" agents and Pandemic influenza
    Kelly J Henrickson; Fiscal Year: 2010
    ..potential threat (Category "A" agents) include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularaemia), and a group of RNA ..
  35. Novel anti-toxin compounds against Yersinia infections
    Maurizio Pellecchia; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis is the infectious agent of bubonic plague, however it can also cause pneumonic and septicemic plague...
  36. HTS assay development targeting Yersinia pestis topoisomerase I
    Yuk Ching Tse-Dinh; Fiscal Year: 2011
    ..The lack of drugs in the pipeline for gram-negative bacteria is especially critical. Yersinia pestis is the causative agent for plague, and multi-drug resistant Y...
  37. Probing localiztion, interactions, and effector properties of Shigella lpaD
    NICHOLAS EUGENE DICKENSON; Fiscal Year: 2010
    ..S. flexneri along with numerous other important pathogens such as Yersinia pestis (plague), Salmonella (gastroenteritis), and Pseudomonas aeruginosa (lung infection) utilize the type III ..
  38. Robert K Ernst; Fiscal Year: 2014
    ..by modifying the lipid A structure of the lipooligosaccharide (LOS) from an attenuated (BSL-2 approved) Yersinia pestis (Yp) strain...
  39. Non-clinical Development of Bactericidal Proteins Targeting Plague
    DAVID WILLIAM MARTIN; Fiscal Year: 2010
    ..1 project we have developed R-type pyocins, targetable bactericidal proteins, that kill the plague bacterium, Yersinia pestis, in vitro and are not sensitive to the mechanisms that bacteria use to resist antibiotics...
  40. Novel antiobiotic development for biodefense
    Michael E Johnson; Fiscal Year: 2010
    Bacillus anthracis, Francisella tularensis and Yersinia pestis, the causative agents for anthrax, tularemia and plague, respectively, are all classed as Category A agents due to their potential use in bioterrorism and biowarfare...
  41. Roy Curtiss Iii; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Yersinia pestis, in three pandemics, resulted in some 200 million plague deaths and is still endemic throughout the world resulting in sporadic infections...
  42. Developing a Novel Plague Antibiotic by Targeting Protein Secretion
    Floyd E Romesberg; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Yersinia pestis, the causative agent of plague, was the most deadly of all the bacterial pathogens in ancient and medieval times...
  43. Phage-mediated bioluminescent detection of Yersinia pestis
    David A Schofield; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Yersinia pestis is designated by the Centers for Disease Control (CDC) and NIAID as a Category A bacterial pathogen. Y...
  44. Bacteriolytic phage enzymes as novel antibacterials against Yersinia pestis
    Ian Molineux; Fiscal Year: 2009
    ..In particular, some isolates of Yersinia pestis, the causative agent of plague, are known to harbor multiple resistance determinants to commonly used ..
  45. Oral Vaccine Platform for Yersinia pestis
    Lloyd F Mayer; Fiscal Year: 2012
    ..In this RO1, we propose to expand our platform technology to develop an oral vaccine against a Category A, bacterial bioterrorism agent, Y. pestis, a highly lethal agent capable of inducing mass casualties. ..
  46. Yersiniabactin and plague pathogenesis
    ROBERT DONALD PERRY; Fiscal Year: 2013
    b>Yersinia pestis causes a zoonotic disease, plague, with well established reservoirs on every inhabited continent except Australia...
  47. Lung Injury and Shock Pathogenesis in Y. pestis Sepsis
    ANDREW LECHNER; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Yersinia pestis is the causative agent of plague, a pandemic clinically divided into bubonic, septicemic, and pneumonic diseases...
  48. MELANIE MARKETON; Fiscal Year: 2014
    ..by developing a new model system in which to identify genetic factors important for the interaction of Yersinia pestis (causative agent of plague) with its flea vector...
  49. William E Goldman; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Pneumonic plague is the deadliest form of disease caused by Yersinia pestis and the basis for this bacterium's classification as a Category A Select Agent...
  50. Development of RSK Inhibitors as Novel Therapeutics for Yersinia pestis
    Jeffrey Smith; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Yersinia pestis, the causative agent of the plague, has been weaponized as an agent of biowarfare. The deliberate release of weaponized Y...
  51. Development of Novel Genetic Tools for Metabolic Selection in Yersinia Pestis
    Deborah Anderson; Fiscal Year: 2009
    b>Yersinia pestis is a Category A Select Agent capable of causing highly fatal, highly contagious pneumonic plague...
  52. Matthew B Lawrenz; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Plague is an acute infection caused by Yersinia pestis, a Gram-negative, facultative intracellular bacterium that infects and survives in macrophages...
  53. Molecular mechanism of immune evasion by Yersinia pestis
    Tomas Mustelin; Fiscal Year: 2003
    ..Due to its very rapid replication and effective immune evading capacity, Yersinia pestis has recently been recognized as a potential tool for bioterrorism...
  54. A Novel Treatment in a Bioterrorism Model of Pneumonic Plague Targets A1 ARs
    CONSTANCE WILSON; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Yersinia pestis (Y...
  55. Phage-mediated bioluminescent detection of Yersinia pestis.
    David Schofield; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Yersinia pestis is designated by the Centers for Disease Control (CDC) and NIAID as a Category A priority bacterial pathogen. Y...
  56. RovA regulon of Yersinia pestis
    VIRGINIA MILLER; Fiscal Year: 2003
    b>Yersinia pestis is a Gram-negative bacterial human pathogen that is the causative agent of plague. Historically Y. pestis has been responsible for significant human morbidity and mortality...
  57. YscE/YscG chaperone-dependent secretion of Yersinia pestis YscF
    Gregory V Plano; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Yersinia pestis, the etiologic agent of plague, uses a type III secretion system (T3SS) to inject effector proteins into eukaryotic cells...
  58. Virulence-conferring siderophore biosynthesis inhibitors
    LUIS QUADRI; Fiscal Year: 2006
    b>Yersinia pestis (Yp), the causative agent of the plague (PL), and Mycobacterium tuberculosis (Mt), the etiologic agent of tuberculosis (TB), are pathogens with an important impact in both global and national public health...
  59. Mucosal Vaccines for Plague
    David Pascual; Fiscal Year: 2006
    ..for plague without the adverse reactions from the inactivated bacillus, more recent studies have defined two Yersinia pestis proteins that can confer 100% protection to both bubonic and pneumonic plague...
  60. HOST RANGE DIVERSITY OF BACTERIOPHAGE FOR Y. PESTIS
    David Martin; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Yersinia pestis, the bacterium responsible for plague, is a Category A pathogen, a significant biowarfare agent...
  61. Mechanism of anti-phagocytosis by Yersinia pestis
    Kristiina Vuori; Fiscal Year: 2005
    b>Yersinia pestis, the causative agent of plague, is one of the most pathogenic bacteria known to mankind. Due to its high pathogenicity, Yersinia has been recognized as a potential weapon for bioterrorism...
  62. Genetic and molecular analysis of Yersinia YopJ
    Neal Silverman; Fiscal Year: 2003
    b>Yersinia pestis is the causative agent of the plague and an important bioterrorism threat. Pneumonic plague is readily transmitted from person to person...
  63. Polymer-Based Yersinia Pestis Point-of-Case Diagnostics
    Jean Clarke; Fiscal Year: 2004
    ..is to develop a highly sensitive and specific multi-locus array diagnostic for rapid identification of Yersinia pestis, the causative agent of plague...
  64. Analogs of GTP as novel inhibitors of bacterial c-di-GMP-synthesizing enzymes
    George E Wright; Fiscal Year: 2010
    ..plays an essential role in the regulation of biofilm formation of important pathogens as Vibrio cholerae, Yersinia pestis, P. aeruginosa, E. coli, S. enteric and S. aureus...
  65. Characterization of Hemolysin A from Proteus mirabilis
    Todd Weaver; Fiscal Year: 2004
    ..including the Ca2+-independent cytolysins/hemolyins from Serratia marcescens, Edwardsiella tarda, Yersinia pestis and Proteus mirabilis. HpmA is secreted and activated by HpmB allowing Proteus to lyse red blood cells...
  66. Multiplex PCR Detection of CDC 'A' Bioterrorism Agents
    Kelly Henrickson; Fiscal Year: 2005
    ..category "A") to pose the greatest threat include Variola major (smallpox), Bacillus anthracis (anthrax), Yersinia pestis (plague), Clostridium botulinum toxin (botulism), Francisella tularensis (tularemia), and a group of RNA ..
  67. HTS assay and configuration for inhibitors of the UDP-Mur formation pathway
    Michael McNeil; Fiscal Year: 2009
    ..a methicillin resistant Staphylococcus aureus and bioterrorist agents including Burkholderia pseudomallei and Yersinia pestis. Here, we target the formation of the key PG biosynthetic precursor, UDP-N-acetyl muramic acid (UDP-MurNAc)...
  68. Applicability of smartDNA Rapid Detection of Priority Agents in Food
    RICHARD BLIDNER; Fiscal Year: 2009
    ..responders for the detection of multiple bio-terrorism agents (Bacillus anthracis, Francisella tularensis and Yersinia pestis)...
  69. Bacterial Pathogen Amplification & Real-Time Detection
    JACK U REN; Fiscal Year: 2003
    ..However in addition to the Category A agents like anthrax, Yersinia pestis and smallpox, which are difficult to safely grow and disseminate, exist the Category B agents that could be ..
  70. Rapid Detection and Identification of Zoonotic Pathogens
    John Dunn; Fiscal Year: 2007
    ..We plan to use Borrelia burgdorferi, the arthropod-borne etiologic agent of Lyme disease and Yersinia pestis, the etiologic agent of plague, as our principle test agents to work through the systems...
  71. BACTERIAL PATHOGEN GENOME INITIATIVE
    Frederick Blattner; Fiscal Year: 1999
    ..In addition to these E. coli genomes we will determine the genomic sequence of Yersinia pestis KIM, causative agent of plague, Shigella flexneri 2 a, the principle agent of dysentary, and Salmonella typhi ..
  72. Structure of the multidrug efflux protein AcrA
    Partho Ghosh; Fiscal Year: 2006
    ..RND efflux systems are also encoded by Escherichia coli O157:H7, Salmonella enterica, Shigella flexneri, and Yersinia pestis. The most thoroughly characterized RND system is the E...
  73. Choosing Drug Doses for Biodefense Pathogens
    George Drusano; Fiscal Year: 2009
    ..doses and schedules of drugs to treat patients infected with the Bioterror pathogens Bacillus anthracis, Yersinia pestis and the Pox viruses Vaccinia Virus and Cowpox Virus...
  74. Development and Formulation of Broad Spectrum Antimicrobials for Biodefense
    Richard A Slayden; Fiscal Year: 2010
    ..the diseases caused by priority pathogens such as Francisella tularensis, Burkholderia pseudomallei and Yersinia pestis. We have developed a series of high affinity inhibitors of the fatty acid biosynthesis enoyl reductase (Fabl) ..

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