Pseudomonas aeruginosa PAO1

Summary

Alias: Pseudomonas aeruginosa str. PAO1, Pseudomonas aeruginosa PA01, Pseudomonas aeruginosa str. PA01

Top Publications

  1. ncbi Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication
    L Passador
    Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, NY 14620
    Science 260:1127-30. 1993
  2. pmc Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa
    Elisabeth Kay
    Département de Microbiologie Fondamentale, Universite de Lausanne, Building Biophore, CH 1015 Lausanne, Switzerland
    J Bacteriol 188:6026-33. 2006
  3. pmc Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1
    Charles F Sio
    Pharmaceutical Biology, University Centre for Pharmacy, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Infect Immun 74:1673-82. 2006
  4. doi Revisiting the quorum-sensing hierarchy in Pseudomonas aeruginosa: the transcriptional regulator RhlR regulates LasR-specific factors
    Valérie Dekimpe
    INRS Institut Armand Frappier, Laval, Quebec H7V 1B7, Canada
    Microbiology 155:712-23. 2009
  5. pmc Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications
    D W Essar
    Microbiology Department, University of Iowa, Iowa City 52242
    J Bacteriol 172:884-900. 1990
  6. pmc Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients
    D W Martin
    Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758
    Proc Natl Acad Sci U S A 90:8377-81. 1993
  7. pmc Promoter specificity in Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR
    M Schuster
    Department of Microbiology and W M Keck Microbial Communities and Cell Signaling Program, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 101:15833-9. 2004
  8. pmc Regulatory RNAs and the HptB/RetS signalling pathways fine-tune Pseudomonas aeruginosa pathogenesis
    Christophe Bordi
    Laboratoire d Ingenierie des Systemes Macromoleculaires, UPR9027, CNRS IMM, Universite de la Mediterranee, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Mol Microbiol 76:1427-43. 2010
  9. doi Identification of mutants with altered phenazine production in Pseudomonas aeruginosa
    Haihua Liang
    Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi an, Shaanxi 710069, PR China
    J Med Microbiol 60:22-34. 2011
  10. pmc Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS
    Abdelali Daddaoua
    Department of Environmental Protection, CSIC EEZ, Granada, Spain
    PLoS ONE 7:e39390. 2012

Patents

  1. METHOD FOR PRODUCING METHACRYLYL-CoA
  2. METHOD FOR PRODUCING METHACRYLYL-CoA
  3. METHOD FOR PRODUCING METHACRYLIC ACID AND/OR ESTER THEREOF
  4. METHOD FOR PRODUCING METACRYLIC ACID
  5. METHOD FOR PRODUCING METHACRYLYL-CoA
  6. Method of preparing isobutyrate
  7. DHAD VARIANTS FOR BUTANOL PRODUCTION
  8. METHOD FOR PRODUCING METHACRYLIC ACID ESTER
  9. METHOD FOR PRODUCING METHACRYLIC ACID AND/OR ESTER THEREOF
  10. METHOD FOR QUANTIFYING TARGET SUBSTANCE

Detail Information

Publications308 found, 100 shown here

  1. ncbi Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication
    L Passador
    Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, NY 14620
    Science 260:1127-30. 1993
    ..PAI provides P. aeruginosa with a means of cell-to-cell communication that is required for the expression of virulence genes and may provide a target for therapeutic approaches...
  2. pmc Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa
    Elisabeth Kay
    Département de Microbiologie Fondamentale, Universite de Lausanne, Building Biophore, CH 1015 Lausanne, Switzerland
    J Bacteriol 188:6026-33. 2006
    ..Both mutants showed increased swarming ability, azurin release, and early biofilm development...
  3. pmc Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1
    Charles F Sio
    Pharmaceutical Biology, University Centre for Pharmacy, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Infect Immun 74:1673-82. 2006
    The virulence of the opportunistic human pathogen Pseudomonas aeruginosa PAO1 is controlled by an N-acyl-homoserine lactone (AHL)-dependent quorum-sensing system. During functional analysis of putative acylase genes in the P...
  4. doi Revisiting the quorum-sensing hierarchy in Pseudomonas aeruginosa: the transcriptional regulator RhlR regulates LasR-specific factors
    Valérie Dekimpe
    INRS Institut Armand Frappier, Laval, Quebec H7V 1B7, Canada
    Microbiology 155:712-23. 2009
    ..This work demonstrates that the QS hierarchy is more complex than the model simply presenting the las system above the rhl system...
  5. pmc Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications
    D W Essar
    Microbiology Department, University of Iowa, Iowa City 52242
    J Bacteriol 172:884-900. 1990
    ..Introduction of an inactivated trpE gene into a phnA mutant abolished residual pyocyanin production, suggesting that the trpE trpG gene products are capable of providing some anthranilate for pyocyanin synthesis...
  6. pmc Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients
    D W Martin
    Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758
    Proc Natl Acad Sci U S A 90:8377-81. 1993
    ....
  7. pmc Promoter specificity in Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR
    M Schuster
    Department of Microbiology and W M Keck Microbial Communities and Cell Signaling Program, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 101:15833-9. 2004
    ..aeruginosa quorum sensing. Insights into the molecular mechanism of LasR function have implications for the development of quorum-sensing targeted antivirulence compounds...
  8. pmc Regulatory RNAs and the HptB/RetS signalling pathways fine-tune Pseudomonas aeruginosa pathogenesis
    Christophe Bordi
    Laboratoire d Ingenierie des Systemes Macromoleculaires, UPR9027, CNRS IMM, Universite de la Mediterranee, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Mol Microbiol 76:1427-43. 2010
    ..We also demonstrate a redundant action of the two sRNAs on T3SS gene expression, while the impact on pel gene expression is additive. These features underpin a novel mechanism in the fine-tuned regulation of gene expression...
  9. doi Identification of mutants with altered phenazine production in Pseudomonas aeruginosa
    Haihua Liang
    Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi an, Shaanxi 710069, PR China
    J Med Microbiol 60:22-34. 2011
    ..These findings suggest that qteE plays an important role in P. aeruginosa pathogenicity and is part of the regulatory networks controlling phenazine production...
  10. pmc Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS
    Abdelali Daddaoua
    Department of Environmental Protection, CSIC EEZ, Granada, Spain
    PLoS ONE 7:e39390. 2012
    ..Data suggest two different mechanisms of control exerted by the same regulator...
  11. pmc AmrZ modulates Pseudomonas aeruginosa biofilm architecture by directly repressing transcription of the psl operon
    Christopher J Jones
    Department of Microbial Infection and Immunity, Ohio State University, Columbus, OH, USA
    J Bacteriol 195:1637-44. 2013
    ..aeruginosa biofilm infections from colonizing to chronic biofilms through repression of the psl operon while activating the algD operon...
  12. pmc Subcellular clustering of the phosphorylated WspR response regulator protein stimulates its diguanylate cyclase activity
    Varisa Huangyutitham
    Department of Microbiology, University of Washington, Seattle, WA, USA
    MBio 4:e00242-13. 2013
    ..Subcellular cluster formation appears to be an additional means by which the activity of a response regulator protein can be regulated...
  13. pmc Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ
    Claudine Baraquet
    Department of Microbiology, University of Washington, Seattle, WA 98195
    Proc Natl Acad Sci U S A 110:18478-83. 2013
    ..aeruginosa. The Walker A motif of FleQ is perfectly conserved, opening up the possibility that other AAA+ ATPases may respond to c-di-GMP. ..
  14. pmc Protein modulator of multidrug efflux gene expression in Pseudomonas aeruginosa
    Denis M Daigle
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Bacteriol 189:5441-51. 2007
    ..Finally, two mutations (L36P and W45A) in ArmR compromising its interaction with MexR have been isolated and mapped to a putative C-terminal alpha-helix of the protein that alone is sufficient for interaction with MexR...
  15. pmc Translational control of the antibiotic inducibility of the PA5471 gene required for mexXY multidrug efflux gene expression in Pseudomonas aeruginosa
    Yuji Morita
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada
    J Bacteriol 191:4966-75. 2009
    ..aeruginosa. These data suggest that PA5471 is not sufficient for MexXY recruitment in response to antibiotic exposure and that additional antibiotic-dependent effects are needed...
  16. pmc Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR
    Hao Chen
    Coordination Chemistry Institute and the State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Hankou Road, Nanjing 210093, People s Republic of China
    EMBO Rep 11:685-90. 2010
    ..1 A. This crystal structure reveals the mechanism by which oxidative signal allosterically derepresses the MexR-controlled transcription activation...
  17. pmc Co-regulation of {beta}-lactam resistance, alginate production and quorum sensing in Pseudomonas aeruginosa
    Deepak Balasubramanian
    Department of Biological Sciences, College of Arts and Science, Florida International University, Miami, FL 33199, USA
    J Med Microbiol 60:147-56. 2011
    ....
  18. pmc Glycosylation is required for outer membrane localization of the lectin LecB in Pseudomonas aeruginosa
    Kai Malte Bartels
    Institute of Microbiology and Biotechnology, Ulm University, Ulm, Germany
    J Bacteriol 193:1107-13. 2011
    ..Furthermore, we demonstrate that this glycosylation is required for the transport of LecB...
  19. pmc Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa
    Olga Zaborina
    Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS Pathog 4:e43. 2008
    ....
  20. pmc The novel two-component regulatory system BfiSR regulates biofilm development by controlling the small RNA rsmZ through CafA
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, New York 13902, USA
    J Bacteriol 192:5275-88. 2010
    ....
  21. pmc The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes
    Jianxin He
    Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 101:2530-5. 2004
    ..The large set of "extra" virulence functions encoded by both PAPIs may contribute to the increased promiscuity of highly virulent P. aeruginosa strains, by directing additional pathogenic functions...
  22. pmc Analysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN
    F Heath Damron
    Department of Biochemistry and Microbiology, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA
    J Bacteriol 194:1317-30. 2012
    ..Together, these data strongly suggest that KinB regulates virulence factors important for the development of acute pneumonia and conversion to mucoidy...
  23. pmc Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors
    M W Tan
    Department of Genetics, Harvard Medical School and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 96:2408-13. 1999
    ..These data indicate that the killing of C. elegans by P. aeruginosa can be exploited to identify novel P. aeruginosa virulence factors important for mammalian pathogenesis...
  24. pmc A novel lipolytic enzyme located in the outer membrane of Pseudomonas aeruginosa
    S Wilhelm
    Lehrstuhl Biologie der Mikroorganismen, Ruhr Universitat, D 44780 Bochum, Germany
    J Bacteriol 181:6977-86. 1999
    A lipase-negative deletion mutant of Pseudomonas aeruginosa PAO1 still showed extracellular lipolytic activity toward short-chain p-nitrophenylesters. By screening a genomic DNA library of P...
  25. pmc Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa
    Joseph B McPhee
    Department of Microbiology and Immunology and Centre for Microbial Diseases and Immunity Research, University of British Columbia, 232 2259 Lower Mall, Vancouver, BC, Canada V6T 1Z4
    J Bacteriol 188:3995-4006. 2006
    ..The number of known PmrA-regulated genes was expanded to include the PA1559-PA1560, PA4782-PA4781, and feoAB operons, in addition to the previously known PA4773-PA4775-pmrAB and pmrHFIJKLM-ugd operons...
  26. pmc Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa
    U A Ochsner
    Institute for Biotechnology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich
    J Bacteriol 176:2044-54. 1994
    ..Additionally, such PG201::'rhlR' mutant strains lacked elastase activity, indicating that the RhlR protein is a pleiotropic regulator...
  27. pmc RsaL, a novel repressor of virulence gene expression in Pseudomonas aeruginosa
    T de Kievit
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Bacteriol 181:2175-84. 1999
    ..RsaL's repressive effect on lasI and the associated decrease in elastase activity have important implications for the expression of all LasR-PAI-1-dependent virulence genes and the overall pathogenicity of P. aeruginosa...
  28. ncbi The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones
    Eric Déziel
    Department of Surgery, Harvard Medical School, Massachusetts General Hospital, 50 Blossom Street, MA, USA
    Mol Microbiol 55:998-1014. 2005
    ..This study provides novel insights into the unique role of the MvfR system in AHL-mediated QS and further supports its importance in P. aeruginosa pathogenesis...
  29. pmc Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product
    Yuji Morita
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario, Canada
    J Bacteriol 188:1847-55. 2006
    ....
  30. ncbi Pseudomonas aeruginosa contains an IHF-like protein that binds to the algD promoter
    B Toussaint
    Biochimie Microbienne CNRS URA 1130 Département de Biologie Moléculaire et Structurale, Centre d Etudes Nucléaires, Grenoble, France
    Biochem Biophys Res Commun 196:416-421. 1993
    ..It is also demonstrated by gel retardation assays that P. aeruginosa IHF forms a stable complex with the algD promoter in vitro, an indication that the protein is involved in the regulation of algD gene expression in P. aeruginosa...
  31. pmc Regulation of pyocin genes in Pseudomonas aeruginosa by positive (prtN) and negative (prtR) regulatory genes
    H Matsui
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    J Bacteriol 175:1257-63. 1993
    ..A model for the regulation of the pyocin genes is proposed...
  32. pmc Identification of the algZ gene upstream of the response regulator algR and its participation in control of alginate production in Pseudomonas aeruginosa
    H Yu
    Department of Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor 48109 0620, USA
    J Bacteriol 179:187-93. 1997
    ....
  33. ncbi Characterization of ptxS, a Pseudomonas aeruginosa gene which interferes with the effect of the exotoxin A positive regulatory gene, ptxR
    J A Colmer
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Mol Gen Genet 258:250-9. 1998
    ..In the presence of ptxS, the level of beta-galactosidase activity produced by the ptxR-lacZ fusion was significantly reduced. These results suggest that ptxS encodes a protein which negatively regulates ptxR expression in P. aeruginosa...
  34. ncbi The R-type pyocin of Pseudomonas aeruginosa is related to P2 phage, and the F-type is related to lambda phage
    K Nakayama
    Department of Bacteriology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Mol Microbiol 38:213-31. 2000
    ....
  35. pmc Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase
    Isaac M Westwood
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 385:605-12. 2005
    ..The recombinant protein has been expressed in sufficient quantity to allow protein crystallization, and we have subsequently determined the 1.95 A structure of PANAT by X-ray crystallography...
  36. ncbi High affinity fucose binding of Pseudomonas aeruginosa lectin PA-IIL: 1.0 A resolution crystal structure of the complex combined with thermodynamics and computational chemistry approaches
    Edward P Mitchell
    E S R F Experiments Division, Grenoble, France
    Proteins 58:735-46. 2005
    ....
  37. pmc Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor
    Jason W Hickman
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Mol Microbiol 69:376-89. 2008
    ..Our results show that FleQ is a new type of c-di-GMP binding protein that controls the transcriptional regulation of EPS biosynthesis genes in P. aeruginosa...
  38. pmc Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX
    Marcos V A S Navarro
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Structure 17:1104-16. 2009
    ..The results provide the structural basis for c-di-GMP sensing via degenerate phosphodiesterases...
  39. doi Transcriptional regulation of Pseudomonas aeruginosa rhlR: role of the CRP orthologue Vfr (virulence factor regulator) and quorum-sensing regulators LasR and RhlR
    Gerardo Croda-García
    Departamento de Biologia Molecular y Biotecnologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Apdo Postal 70228, Mexico DF 04510, Mexico
    Microbiology 157:2545-55. 2011
    ..We also show that rhlR transcription is subject to positive-feedback autoregulation through RhlR/C4-HSL activation of the rhlA promoter. This positive autoregulation plays a major role in rhlR expression...
  40. pmc A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence
    Jana Goldová
    Cell and Molecular Microbiology Division, Institute of Microbiology of the ASCR, v v i, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    BMC Genomics 12:437. 2011
    ..To determine the biological function of this protein pair, we prepared a pppA-ppkA double mutant and characterised its phenotype and transcriptomic profiles...
  41. pmc Surface sensing and lateral subcellular localization of WspA, the receptor in a chemosensory-like system leading to c-di-GMP production
    Jennifer R O'Connor
    Departments of Microbiology, University of Washington, Seattle, WA 98195, USA
    Mol Microbiol 86:720-9. 2012
    ..Thus, the amino acid sequence of the WspA periplasmic region did not need to be conserved for the Wsp system to respond to surfaces...
  42. pmc Deep sequencing analyses expands the Pseudomonas aeruginosa AmpR regulon to include small RNA-mediated regulation of iron acquisition, heat shock and oxidative stress response
    Deepak Balasubramanian
    Department of Biological Sciences, College of Arts and Science, Florida International University, Miami, FL 33199, USA, Department of Molecular Microbiology and Infectious Diseases, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA, BioRG, School of Computing and Information Science, College of Engineering and Computing, Florida International University, Miami, FL 33199, USA, Division of Infectious Diseases, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA and Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Nucleic Acids Res 42:979-98. 2014
    ..This study further attests to the role of AmpR in regulating virulence and physiological processes in P. aeruginosa. ..
  43. pmc Phosphorylation-independent regulation of the diguanylate cyclase WspR
    Nabanita De
    Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS Biol 6:e67. 2008
    ..A structural comparison reveals resemblance of the oligomeric states to assemblies of GAF domains, widely used regulatory domains in signaling molecules conserved from archaea to mammals, suggesting a similar mechanism of regulation...
  44. pmc MexT regulates the type III secretion system through MexS and PtrC in Pseudomonas aeruginosa
    Yongxin Jin
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida 326101, USA
    J Bacteriol 193:399-410. 2011
    ..A model has been proposed for the MexS/MexT-mediated regulation of the T3SS, the MexEF efflux pump, and the production of elastase and pyocyanin...
  45. pmc Mucoid-to-nonmucoid conversion in alginate-producing Pseudomonas aeruginosa often results from spontaneous mutations in algT, encoding a putative alternate sigma factor, and shows evidence for autoregulation
    C A Devries
    Department of Microbiology and Immunology, University of Tennessee, Memphis 38163
    J Bacteriol 176:6677-87. 1994
    ..A plasmid-borne algT gene in PAO1 resulted in both the mucoid phenotype and high levels of algT transcripts, further supporting the hypothesis that AlgT controls its own gene expression and expression of genes of the alginate regulon...
  46. ncbi Isolation and characterization of a Pseudomonas aeruginosa gene, ptxR, which positively regulates exotoxin A production
    A N Hamood
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Mol Microbiol 21:97-110. 1996
    ..These results suggest that ptxR regulates (through regA) exotoxin A production at the transcriptional level...
  47. pmc Assembly of fimbrial structures in Pseudomonas aeruginosa: functionality and specificity of chaperone-usher machineries
    Ségolène Ruer
    Laboratoire d Ingenierie des Systemes Macromoleculaires, CNRS IBSM UPR9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Bacteriol 189:3547-55. 2007
    ..Finally, we observed that the CupB and CupC systems are specialized in the assembly of their own fimbrial subunits and are not exchangeable...
  48. pmc Role of LecA and LecB lectins in Pseudomonas aeruginosa-induced lung injury and effect of carbohydrate ligands
    Chanez Chemani
    EA 2689, Faculte de Medecine, 1 place de Verdun, F 59045 Lille Cedex, France
    Infect Immun 77:2065-75. 2009
    ..Our results demonstrate that there is a relationship between lectins and the pathogenicity of P. aeruginosa. Inhibition of the lectins by specific carbohydrates may provide new therapeutic perspectives...
  49. pmc The functional role of a conserved loop in EAL domain-based cyclic di-GMP-specific phosphodiesterase
    Feng Rao
    School of Biological Sciences, Nanyang Technological University, Singapore
    J Bacteriol 191:4722-31. 2009
    ....
  50. pmc Chlorinated phenols control the expression of the multidrug resistance efflux pump MexAB-OprM in Pseudomonas aeruginosa by interacting with NalC
    Sudeshna Ghosh
    Department of Civil and Environmental Engineering, University of Michigan, 2350 Hayward Street, 2340 GG Brown, Ann Arbor, MI 48109 2125, USA
    Mol Microbiol 79:1547-56. 2011
    ..Thus, the NalC-chlorinated phenol interaction is likely a pertinent physiological mechanism that P. aeruginosa uses to control expression of the MexAB-OprM efflux pump...
  51. pmc Organization and PprB-dependent control of the Pseudomonas aeruginosa tad Locus, involved in Flp pilus biology
    Christophe S Bernard
    Membrane Complexes and Pathogenicity in Pseudomonas aeruginosa, CNRS LISM UPR9027 Aix Marseille Université, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Bacteriol 191:1961-73. 2009
    ..However, our results suggest that the putative RcpC protein modifies the Flp pilin, thereby promoting Flp-dependent adhesion to eukaryotic cells...
  52. ncbi Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model
    S Mahajan-Miklos
    Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    Cell 96:47-56. 1999
    ..elegans killing are also required for pathogenesis in plants and mice, illustrating that this model tackles the dual challenges of identifying bacterial virulence factors as well as host responses to them...
  53. ncbi Pseudomonas aeruginosa AlgZ, a ribbon-helix-helix DNA-binding protein, is essential for alginate synthesis and algD transcriptional activation
    P J Baynham
    Department of Microbiology and Immunology, Medical Center Boulevard, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Microbiol 33:1069-80. 1999
    ..The cloning of algZ is a crucial step in determining the mechanism of algD activation...
  54. pmc Acyl-homoserine lactone binding to and stability of the orphan Pseudomonas aeruginosa quorum-sensing signal receptor QscR
    Ken ichi Oinuma
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    J Bacteriol 193:421-8. 2011
    ..Our data support a model whereby QscR polypeptides fold properly in the absence of an acyl-HSL, but soluble, acyl-HSL-free QscR does not accumulate because it is subject to rapid aggregation or proteolysis...
  55. pmc Full virulence of Pseudomonas aeruginosa requires OprF
    Laurène Fito-Boncompte
    Laboratoire de Microbiologie du Froid, Signaux et Micro Environnement, 55 rue St Germain, 27000 Evreux, France
    Infect Immun 79:1176-86. 2011
    ..This is the first study showing a link between OprF, PQS synthesis, T3SS, and virulence factor production, providing novel insights into virulence expression...
  56. ncbi MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719
    Lily Cao
    Department of Microbiology and Immunology, Queen s University, Kingston, ON, Canada, K7L 3N6
    Mol Microbiol 53:1423-36. 2004
    ..The deduced products of PA3720-PA3719 show no homology to sequences presently in the GenBank databases, however, and as such provide no clues as to how this might occur...
  57. ncbi Regulation of the Pseudomonas aeruginosa toxA, regA and ptxR genes by the iron-starvation sigma factor PvdS under reduced levels of oxygen
    Jennifer M Gaines
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Microbiology 153:4219-33. 2007
    ..Thus, PvdS may control the transcription of the ptxR, regA and toxA genes, and respond to EO by acting at different levels of the toxA regulatory cascade...
  58. doi The major outer membrane protein OprG of Pseudomonas aeruginosa contributes to cytotoxicity and forms an anaerobically regulated, cation-selective channel
    Joseph B McPhee
    Centre for Microbial Diseases and Immunity Research, University of British Columbia, Lower Mall Research Station, Vancouver, BC, Canada
    FEMS Microbiol Lett 296:241-7. 2009
    ....
  59. pmc An H(+)-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa
    Gui Xin He
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700 8530, Japan
    J Bacteriol 186:262-5. 2004
    ..aeruginosa revealed that PmpM is functional and that benzalkonium chloride, fluoroquinolones, ethidium bromide, acriflavine, and tetraphenylphosphonium chloride are substrates for PmpM in this microorganism...
  60. pmc Structure determination of an FMN reductase from Pseudomonas aeruginosa PA01 using sulfur anomalous signal
    Rakhi Agarwal
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Acta Crystallogr D Biol Crystallogr 62:383-91. 2006
    ..28 A resolution of an NAD(P)H-dependent FMN reductase flavoprotein from Pseudomonas aeruginosa PA01-derived protein Q9I4D4 using the anomalous signal from an unusually small number of S atoms is reported...
  61. pmc The Pseudomonas aeruginosa LasB metalloproteinase regulates the human urokinase-type plasminogen activator receptor through domain-specific endoproteolysis
    Dominique Leduc
    INSERM, U874, Paris F 75015, France Unité de Défense Innée et Inflammation, Institut Pasteur, Paris F 75015, France
    Infect Immun 75:3848-58. 2007
    ..The LasB proteinase is thus endowed with a high potential for the alteration of uPAR expression and functioning on inflammatory cells during infections by P. aeruginosa...
  62. pmc A unique regulator controls the activation threshold of quorum-regulated genes in Pseudomonas aeruginosa
    Richard Siehnel
    Department of Medicine and Microbiology, University of Washington School of Medicine, Seattle, WA 98195 7242, USA
    Proc Natl Acad Sci U S A 107:7916-21. 2010
    ..This unique regulator governs two central QS control points in P. aeruginosa and shapes the expression pattern thought fundamental to the biological functions of QS...
  63. pmc The novel Pseudomonas aeruginosa two-component regulator BfmR controls bacteriophage-mediated lysis and DNA release during biofilm development through PhdA
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA
    Mol Microbiol 81:767-83. 2011
    ..Therefore, we propose that BfmR regulates biofilm development by limiting bacteriophage-mediated lysis and thus, eDNA release, via PhdA...
  64. pmc fleN, a gene that regulates flagellar number in Pseudomonas aeruginosa
    N Dasgupta
    Department of Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Bacteriol 182:357-64. 2000
    ..Based on these results, we propose a model where FleN influences FleQ activity (directly or indirectly) in regulating flagellar number in P. aeruginosa...
  65. pmc Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of Pseudomonas aeruginosa
    Stephanie Perret
    Centre de Recherches sur les Macromolecules Vegetales, CNRS, Universite Joseph Fourier, BP53, 38041 Grenoble Cedex 09, France
    Biochem J 389:325-32. 2005
    ..This study provides important structural information about compounds that could be of general application in new therapeutic strategies against bacterial infections...
  66. ncbi mvaT mutation modifies the expression of the Pseudomonas aeruginosa multidrug efflux operon mexEF-oprN
    Landon W Westfall
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    FEMS Microbiol Lett 255:247-54. 2006
    ..We show that mvaT mutation does not affect mexEF-oprN expression through mexT or mexS. We also explored several other potential mechanisms...
  67. pmc Role of Vfr in regulating exotoxin A production by Pseudomonas aeruginosa
    Marko Davinic
    Department of Biological Sciences, Texas Tech University, School of Medicine, MS3131, Lubbock, TX 79409, USA
    Microbiology 155:2265-73. 2009
    ....
  68. doi Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa
    Hideaki Maseda
    Department of Biological Science and Technology, Institute of Technology and Science, The University of Tokushima Graduate School, Tokushima, Japan
    FEMS Microbiol Lett 311:36-43. 2010
    ..Deletion of this region caused a sudden rise in MexEF-OprN production, suggesting that this region accommodates the binding of a putative repressor protein...
  69. ncbi Cloning and analysis of the gene for the major outer membrane lipoprotein from Pseudomonas aeruginosa
    P Cornelis
    Laboratoire de Microbiologie, CNRS, Universite Louis Pasteur, Strasbourg, France
    Mol Microbiol 3:421-8. 1989
    ..aeruginosa (Mizuno and Kageyama, 1979) were identical. In contrast with other Gram-negative outer membrane lipoproteins, conformation predictions suggested that the mature protein was a single alpha helix...
  70. pmc Biochemical characterization of the naturally occurring oxacillinase OXA-50 of Pseudomonas aeruginosa
    Delphine Girlich
    Service de Bacteriologie Virologie, Universite Paris XI, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 48:2043-8. 2004
    ..gene (formerly known as the PA5514 gene) is an oxacillinase gene identified in silico in the genome of Pseudomonas aeruginosa PAO1. By using a mutant strain of P...
  71. ncbi Characterization of poxB, a chromosomal-encoded Pseudomonas aeruginosa oxacillinase
    Kok Fai Kong
    Department of Biological Sciences, Florida International University, University Park, Miami, FL 33199, USA
    Gene 358:82-92. 2005
    ..Our studies show that P. aeruginosa possesses two beta-lactamases, AmpC and PoxB, which contribute to its resistance against a wide spectrum of beta-lactam antibiotics...
  72. pmc PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa
    Yong Mei Zhang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Biol Chem 283:28788-94. 2008
    ..DHQ was produced by Escherichia coli coexpressing PqsA and PqsD, illustrating that these two proteins are the only factors necessary for DHQ synthesis. Thus, PqsD is responsible for the production of DHQ in P. aeruginosa...
  73. ncbi WaaL of Pseudomonas aeruginosa utilizes ATP in in vitro ligation of O antigen onto lipid A-core
    Priyanka D Abeyrathne
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Mol Microbiol 65:1345-59. 2007
    ..A waaL mutant of P. aeruginosa could not be cross-complemented by waaL of Escherichia coli, which suggested that each of these proteins has specificity for its cognate core oligosaccharide...
  74. pmc Pseudomonas aeruginosa PqsA is an anthranilate-coenzyme A ligase
    James P Coleman
    Department of Microbiology and Immunology, The Brody School of Medicine at East Carolina University, 600 Moye Blvd, Greenville, North Carolina 27834, USA
    J Bacteriol 190:1247-55. 2008
    ..aeruginosa...
  75. doi Regulation of Pseudomonas aeruginosa ptxR by Vfr
    Evan Ferrell
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Microbiology 154:431-9. 2008
    ..Our results suggest that Vfr modulates toxA and lasB expression in PAO1 through PtxR. A model defining the relationships between these different genes is presented...
  76. pmc AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin
    Carrie Lynn Keiski
    Molecular Structure and Function, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Structure 18:265-73. 2010
    ....
  77. pmc Characterization of the Pseudomonas aeruginosa metalloendopeptidase, Mep72, a member of the Vfr regulon
    Aysegul Balyimez
    Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    BMC Microbiol 13:269. 2013
    ..A previous microarray analysis identified numerous genes positively regulated by Vfr in strain PAK, including the yet uncharacterized PA2782 and PA2783...
  78. pmc Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors
    L G Rahme
    Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    Proc Natl Acad Sci U S A 94:13245-50. 1997
    ..These results demonstrate that an alternative nonvertebrate host of a human bacterial pathogen can be used in an in vivo high throughput screen to identify novel bacterial virulence factors involved in mammalian pathogenesis...
  79. pmc Characterization of Pseudomonas aeruginosa chitinase, a gradually secreted protein
    J Folders
    Department of Molecular Microbiology, Institute of Biomembranes, Utrecht University, Utrecht, The Netherlands
    J Bacteriol 183:7044-52. 2001
    ..This release could not be ascribed to cell lysis. Since ChiC did not appear to be secreted via any of the known secretion systems, a novel secretion pathway seems to be involved...
  80. ncbi Bacteriostatic and bactericidal activities of eight fluoroquinolones against MexAB-OprM-overproducing clinical strains of Pseudomonas aeruginosa
    Philippe Dupont
    Laboratoire de Bacteriologie, Centre Hospitalier Universitaire J Minjoz, 25030 Besancon, France
    J Antimicrob Chemother 55:518-22. 2005
    ..To assess the impact of stable overproduction of efflux system MexAB-OprM on the bacteriostatic and bactericidal activities of fluoroquinolones against clinical Pseudomonas aeruginosa strains...
  81. pmc NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa
    Laura Zamorano
    Servicio de Microbiología and Unidad de Investigación, Instituto Universitario de Investigación en Ciencias de la Salud, Palma de Mallorca, Spain
    Antimicrob Agents Chemother 54:3557-63. 2010
    ..Therefore, NagZ is envisaged to be a candidate target for preventing and reverting beta-lactam resistance in P. aeruginosa...
  82. pmc Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway
    S A Hyland
    Department of Enzymology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Bacteriol 179:2029-37. 1997
    ..The lpxC gene has no significant homology with amidase signature sequences. Therefore, we assign this protein to the metalloamidase family as a member with a novel structure...
  83. pmc A novel reduced flavin mononucleotide-dependent methanesulfonate sulfonatase encoded by the sulfur-regulated msu operon of Pseudomonas aeruginosa
    M A Kertesz
    Institute of Microbiology, Swiss Federal Institute of Technology, ETH Zentrum, CH 8092 Zurich, Switzerland
    J Bacteriol 181:1464-73. 1999
    ....
  84. ncbi Unique complex between bacterial azurin and tumor-suppressor protein p53
    David Apiyo
    Department of Biochemistry and Cell Biology, Rice University, 6100 Main Street, Houston, TX 77251, USA
    Biochem Biophys Res Commun 332:965-8. 2005
    ..Further biophysical studies may assist the design of novel cancer treatments that are based on azurin...
  85. pmc Pseudomonas aeruginosa porin OprF: properties of the channel
    Ekaterina M Nestorovich
    Laboratory of Physical and Structural Biology, NICHD National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892 0924, USA
    J Biol Chem 281:16230-7. 2006
    ....
  86. pmc Effect of site-specific mutations in different phosphotransfer domains of the chemosensory protein ChpA on Pseudomonas aeruginosa motility
    Andrew J Leech
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia
    J Bacteriol 188:8479-86. 2006
    ..aeruginosa motility that are not evident from the conventional twitching stab assay. Together, these results suggest that ChpA plays a central role in the complex regulation of type IV pilus-mediated motility in P. aeruginosa...
  87. ncbi Molecular cloning and characterization of the rfc gene of Pseudomonas aeruginosa (serotype O5)
    T R De Kievit
    Canadian Bacterial Disease Network, University of Guelph, Ontario, Canada
    Mol Microbiol 16:565-74. 1995
    ..Furthermore, comparison of the amino acid composition and codon usage of the P. aeruginosa Rfc with other Rfc proteins revealed significant similarity between them...
  88. pmc Cloning and characterization of the Pseudomonas aeruginosa zwf gene encoding glucose-6-phosphate dehydrogenase, an enzyme important in resistance to methyl viologen (paraquat)
    J F Ma
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524, USA
    J Bacteriol 180:1741-9. 1998
    ..Since one by-product of G6PDH activity is NADPH, the latter data suggest that this cofactor is essential for the activity of enzymes critical in defense against paraquat toxicity...
  89. pmc Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance
    X Z Li
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Bacteriol 180:2987-91. 1998
    ..These data suggest that the efflux of organic solvents is a factor in the tolerance of P. aeruginosa to these compounds and that the multidrug efflux systems of this organism can accommodate organic solvents, as well as antibiotics...
  90. pmc nalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa
    Yuji Morita
    Department of Microbiology and Immunology, Queen s University, Kingston, ON, Canada K7L 3N6
    J Bacteriol 188:8649-54. 2006
    ..Moreover, increased expression from this promoter was seen in a nalD mutant, consistent with NalD directly controlling mexAB-oprM expression from a second promoter...
  91. ncbi The second messenger bis-(3'-5')-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa
    Massimo Merighi
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mol Microbiol 65:876-95. 2007
    ..Alg44 appears to be an essential component of the alginate biosynthetic apparatus, where, following binding of c-di-GMP, it controls polymerization or transport of the polysaccharide...
  92. pmc Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix
    Bradley R Borlee
    Department of Microbiology, University of Washington, Box 357242, Seattle, WA 98195 7242, USA
    Mol Microbiol 75:827-42. 2010
    ..Thus, this study identifies a key protein structural component of the P. aeruginosa EPS matrix...
  93. pmc Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression
    M J Gambello
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York 14642
    J Bacteriol 173:3000-9. 1991
    We report the discovery of the lasR gene, which positively regulates elastase expression in Pseudomonas aeruginosa PAO1. The lasR gene was cloned by its ability to restore a positive elastase phenotype in strain PA103, a strain which ..
  94. pmc Pseudomonas aeruginosa AlgG is a polymer level alginate C5-mannuronan epimerase
    M J Franklin
    Department of Microbiology and Immunology, University of Tennessee, Memphis
    J Bacteriol 176:1821-30. 1994
    ..These results demonstrate that AlgG has polymer-level mannuronan C5-epimerase activity...
  95. ncbi Cyclohexadienyl dehydratase from Pseudomonas aeruginosa is a periplasmic protein
    G Zhao
    Department of Microbiology and Cell Science, University of Florida, Gainesville 32611 0144
    J Gen Microbiol 139:807-13. 1993
    ..Electron microscopy using immunogold labelling showed an apparent localization of cyclohexadienyl dehydratase at the polar regions of the periplasmic space in E. coli...
  96. ncbi The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase
    C Reimmann
    Laboratoire de Biologie Microbienne, Universite de Lausanne, Switzerland
    Mol Microbiol 24:309-19. 1997
    ..The gacA gene of Pseudomonas aeruginosa PAO1 was isolated and its role in cell-density-dependent gene expression was characterized...
  97. pmc Fatty acid biosynthesis in Pseudomonas aeruginosa: cloning and characterization of the fabAB operon encoding beta-hydroxyacyl-acyl carrier protein dehydratase (FabA) and beta-ketoacyl-acyl carrier protein synthase I (FabB)
    T T Hoang
    Department of Microbiology, Colorado State University, Fort Collins 80523, USA
    J Bacteriol 179:5326-32. 1997
    ..By physical and genetic mapping, the fabAB genes were localized between 3.45 and 3.6 Mbp on the 5.9-Mbp chromosome, which corresponds to the 58- to 59.5-min region of the genetic map...
  98. ncbi The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression
    Landon W Westfall
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Microbiology 150:3797-806. 2004
    ..The expression of ptxS was lower in PAODeltamvaT than in PAO1, but no difference was detected in ptxR expression. These results suggest that MvaT positively regulates ptxS expression by binding specifically to the ptxS upstream region...
  99. ncbi Identification of an HptB-mediated multi-step phosphorelay in Pseudomonas aeruginosa PAO1
    Ching Ting Lin
    Department of Biological Science and Technology, National Chiao Tung University, 75 Po Ai Street, Hsin Chu 30050, Taiwan, Republic of China
    Res Microbiol 157:169-75. 2006
    ..carries out specific signal transduction, through HptB (PA3345), to the response regulator PA3346 in Pseudomonas aeruginosa PAO1. As assessed by phenotypic changes in the hptB deletion mutant, the pathway is likely to be involved in ..
  100. ncbi Influence of ptsP gene on pyocyanin production in Pseudomonas aeruginosa
    Haijin Xu
    Tianjin Key Laboratory of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, PR China
    FEMS Microbiol Lett 253:103-9. 2005
    ..Our results showed that the ptsP gene has an important role in the regulation of pyocyanin production and that two quorum-sensing systems and their repressor QscR are involved in this regulation...
  101. pmc Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa
    Olga Zaborina
    Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS Pathog 3:e35. 2007
    ..Taken together, these data demonstrate that P. aeruginosa can intercept opioid compounds released during host stress and integrate them into core elements of quorum sensing circuitry leading to enhanced virulence...

Research Grants9

  1. Genetic basis of P. aeruginosa lung infections in mice
    Hongwei Yu; Fiscal Year: 2004
    ..The discovery of the mouse susceptibility gene may lead to the identification of the human homologue (lung-specific modifier gene) presumed to mediate susceptibility in the initial phase of infection. ..
  2. Redox control of Nrf2/ARE by thioredoxin and GSH
    Jason Hansen; Fiscal Year: 2005
    ..The roles of GSH and cytosolic and nuclear TRX during NRF2 activation and binding will provide an essential foundation for future developmental toxicology. ..
  3. Analysis of Toxin A synthesis in P. aeruginosa
    Abdul Hamood; Fiscal Year: 2006
    ....
  4. Hydrophobics transport across the outer membrane
    Bert van den Berg; Fiscal Year: 2009
    ..These structures will also allow us to determine whether mechanistic differences exist between LCFA and xenobiotics transport. ..
  5. P. Aeruginosa Biofilms and Burn Wound Infections
    Karin Sauer; Fiscal Year: 2006
    ..aeruginosa pathogenesis and by identifying virulence factors that may be targeted for therapeutic intervention. ..
  6. P. aeruginosa biofilm specific proteins and regulators
    Karin Sauer; Fiscal Year: 2007
    ..Findings from this research are intended to lead to novel and more effective approaches for the treatment of such biofilm infections. [unreadable] [unreadable] [unreadable] [unreadable]..
  7. ROLE OF A NEW SIGNAL MOLECULE IN P. AERUGINOSA VIRULENCE
    EVERETT PESCI; Fiscal Year: 2004
    ..The long term goal of this proposal is to determine the role of PQS in the pathogenesis of P. aeruginosa infections with the hope it will lead to new and effective therapies against aeruginosa. ..
  8. PROTEASE SECRETION IN PSEUDOMONAS AERUGINOSA
    DENNIS OHMAN; Fiscal Year: 2003
    ..It also provides a model system for understanding a major pathway of protein export in gram-negative bacteria. ..
  9. Transport of Folates and Their Precursors in Plants
    Andrew Hanson; Fiscal Year: 2008
    ..Studies of the cognate plant carriers could thus help develop new chemotherapies for leishmaniasis. I ..

Patents33

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  2. METHOD FOR PRODUCING METHACRYLYL-CoA
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  3. METHOD FOR PRODUCING METHACRYLIC ACID AND/OR ESTER THEREOF
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  4. METHOD FOR PRODUCING METACRYLIC ACID
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  5. METHOD FOR PRODUCING METHACRYLYL-CoA
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  6. Method of preparing isobutyrate
    Patent Number: JP2015116141-A; Date:2015-06-25
  7. DHAD VARIANTS FOR BUTANOL PRODUCTION
    Patent Number: WO2014106107-A2; Date:2014-07-03
  8. METHOD FOR PRODUCING METHACRYLIC ACID ESTER
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  9. METHOD FOR PRODUCING METHACRYLIC ACID AND/OR ESTER THEREOF
    Patent Number: KR1020140092386-A; Date:2014-07-23
  10. METHOD FOR QUANTIFYING TARGET SUBSTANCE
    Patent Number: KR1020150031220-A; Date:2015-03-23
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    Patent Number: WO2007017270-A1; Date:2007-02-15
  12. Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
    Patent Number: EP1752532-A1; Date:2007-02-14
  13. A method for causing or enhancing positive chemotaxis for trichloroethylene in bacteria
    Patent Number: JP2007295804-A; Date:2007-11-15
  14. PREPARATION METHOD OF LACTATE POLYMERS AND LACTATE COPOLYMERS USING POLYHYDROXYALKANOATE SYNTHASE MUTANTS
    Patent Number: EP2471910-A2; Date:2012-07-04
  15. Gene of amidase hydrolyzing (R)-form amide bond selectively and use of the same
    Patent Number: JP2004105152-A; Date:2004-04-08
  16. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  17. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  18. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27
  19. Methods for quantitation of subject substance
    Patent Number: WO2013118894-A; Date:2013-08-15
  20. Method for quantitation of amino acids using pyrophosphoric acid quantitation
    Patent Number: JP2013162752-A; Date:2013-08-22
  21. Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
    Patent Number: JP2009504146-A; Date:2009-02-05
  22. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  23. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  24. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  25. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  26. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  27. Plants with increased yield (lt)
    Patent Number: WO2010034672-A1; Date:2010-04-01
  28. Plants with increased yield by increasing or generating one or more activities in a plant or a part thereof
    Patent Number: WO2010020654-A2; Date:2010-02-25
  29. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  30. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
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  32. Plants with increased yield
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  33. Plants with increased yield
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