Klebsiella pneumoniae

Summary

Alias: "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886, "Bacterium pneumoniae crouposae" Zopf 1885, "Hyalococcus pneumoniae" Schroeter 1886, Bacillus pneumoniae, Bacterium pneumoniae crouposae, Hyalococcus pneumoniae, Klebsiella pneumoniae (Schroeter 1886) Trevisan 1887, Klebsiella sp. M-AI-2

Top Publications

  1. ncbi Antimicrobial susceptibility of respiratory isolates of Enterobacteriaceae and Staphylococcus aureus in Italy: incidence and trends over the period 1997-1999
    R Fontana
    Department of Pathology, University of Verona, Italy
    Eur J Clin Microbiol Infect Dis 20:854-63. 2001
  2. pmc Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae
    Andrea Endimiani
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 55:82-5. 2011
  3. ncbi Genetic organization of antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331
    M E Tolmasky
    Department of Microbiology and Immunology L220, School of Medicine, Oregon Health Sciences University, Portland 97201 3098
    Plasmid 29:31-40. 1993
  4. pmc Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae
    Laurent Poirel
    Service de Bacteriologie Virologie, Universite Paris XI, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:15-22. 2004
  5. pmc Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London, United Kingdom
    Antimicrob Agents Chemother 48:4793-9. 2004
  6. pmc Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC in a Klebsiella pneumoniae isolate from France
    Thierry Naas
    Antimicrob Agents Chemother 49:4423-4. 2005
  7. doi Outbreak caused by a multi-resistant Klebsiella pneumoniae strain of new sequence type ST341 carrying new genetic environments of aac(6')-Ib-cr and qnrS1 genes in a neonatal intensive care unit in Spain
    Elena Ruiz
    Área de Bioquímica y Biología Molecular, Departamento de Agricultura y Alimentación, Universidad de La Rioja, Logrono, Spain
    Int J Med Microbiol 300:464-9. 2010
  8. doi Duplication of the chromosomal blaSHV-11 gene in a clinical hypermutable strain of Klebsiella pneumoniae
    Chloé Duvernay
    CNRS UMR 5234, Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Microbiology 157:496-503. 2011
  9. pmc Genetic context and structural diversity of class 1 integrons from human commensal bacteria in a hospital intensive care unit
    Thu Betteridge
    The ithree Institute, University of Technology, P O Box 123, Broadway, Sydney, NSW 2007, Australia
    Antimicrob Agents Chemother 55:3939-43. 2011
  10. doi Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan
    Chung Yu Chang
    Department of Microbiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Diagn Microbiol Infect Dis 65:214-6. 2009

Patents

  1. KITS FOR ANALYZING SINGLE-STRANDED NUCLEIC ACID SEQUENCES
  2. METHODS OF DETECTION OF MULTIDRUG RESISTANT BACTERIA
  3. DETECTION METHOD
  4. LIGHT-DRIVEN CO2 REDUCTION TO ORGANIC COMPOUNDS TO SERVE AS FUELS OR AS INDUSTRIAL HALF PRODUCTS BY AN AUTOTROPH CONTAINING A FERMENTATIVE GENE CASSETTE
  5. PROTEINS AND NUCLEIC ACIDS USEFUL IN VACCINES TARGETING KLEBSIELLA PNEUMONIAE
  6. Modified microorganism for optimized production of 1,4-butanediol
  7. METHOD OF DETECTING GENES RESPONSIBLE FOR RESISTANCE TO BETA-LACTAM ANTIBIOTICS
  8. METHOD AND DEVICE FOR DETECTING A CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE
  9. A MODIFIED MICROORGANISM FOR THE OPTIMIZED PRODUCTION OF 2,4-DIHYDROXYBURYRATE WITH ENHANCED 2,4-DIHYDROXYBUTYRATE EFFLUX
  10. Avirulent and Psychrophilic Corynebacterium glutamicum Strains Having Excellent Production Potential of 2,3-Butanediol and Method for Preparing Thereof

Detail Information

Publications272 found, 100 shown here

  1. ncbi Antimicrobial susceptibility of respiratory isolates of Enterobacteriaceae and Staphylococcus aureus in Italy: incidence and trends over the period 1997-1999
    R Fontana
    Department of Pathology, University of Verona, Italy
    Eur J Clin Microbiol Infect Dis 20:854-63. 2001
    ..A standardised method was used to determine the MICs of 22 antibiotics against isolates of Klebsiella pneumoniae (n=870), Escherichia coli (n=684), Enterobacter cloacae (n=342), Enterobacter aerogenes (n=187) and ..
  2. pmc Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae
    Andrea Endimiani
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 55:82-5. 2011
    ..We chose two KPC-producing Klebsiella pneumoniae strains (VA-361 and VA-406) showing MICs of CAZ of ≥256 μg/ml...
  3. ncbi Genetic organization of antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331
    M E Tolmasky
    Department of Microbiology and Immunology L220, School of Medicine, Oregon Health Sciences University, Portland 97201 3098
    Plasmid 29:31-40. 1993
    ..Hall, D. Brookes, and H. W. Stokes (1991) Mol. Microbiol. 5, 1941-1959)...
  4. pmc Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae
    Laurent Poirel
    Service de Bacteriologie Virologie, Universite Paris XI, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 48:15-22. 2004
    b>Klebsiella pneumoniae strain 11978 was isolated in Turkey in 2001 and was found to be resistant to all beta-lactams, including carbapenems...
  5. pmc Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London, United Kingdom
    Antimicrob Agents Chemother 48:4793-9. 2004
    ..Y., were infected or colonized by carbapenem-resistant Klebsiella pneumoniae. Pulsed-field gel electrophoresis identified a predominant outbreak strain, but other resistant strains ..
  6. pmc Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC in a Klebsiella pneumoniae isolate from France
    Thierry Naas
    Antimicrob Agents Chemother 49:4423-4. 2005
  7. doi Outbreak caused by a multi-resistant Klebsiella pneumoniae strain of new sequence type ST341 carrying new genetic environments of aac(6')-Ib-cr and qnrS1 genes in a neonatal intensive care unit in Spain
    Elena Ruiz
    Área de Bioquímica y Biología Molecular, Departamento de Agricultura y Alimentación, Universidad de La Rioja, Logrono, Spain
    Int J Med Microbiol 300:464-9. 2010
    An outbreak due to a Klebsiella pneumoniae clone occurred in a neonatal intensive care unit of a Spanish Hospital in which three newborns were infected (all with gestational age ≤29 weeks; two of them died) and seven were colonized (..
  8. doi Duplication of the chromosomal blaSHV-11 gene in a clinical hypermutable strain of Klebsiella pneumoniae
    Chloé Duvernay
    CNRS UMR 5234, Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Microbiology 157:496-503. 2011
    In a collection of 110 clinical isolates of Klebsiella pneumoniae, a single strain, Kp593, was found to exhibit a mutator phenotype with a rifampicin mutation frequency 100-fold higher than the modal value for this species...
  9. pmc Genetic context and structural diversity of class 1 integrons from human commensal bacteria in a hospital intensive care unit
    Thu Betteridge
    The ithree Institute, University of Technology, P O Box 123, Broadway, Sydney, NSW 2007, Australia
    Antimicrob Agents Chemother 55:3939-43. 2011
    ..The diversity and abundance of class 1 integrons identified are such that many novel elements seen here would not have been identified by commonly used methods, and they revealed an additional level of complexity...
  10. doi Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan
    Chung Yu Chang
    Department of Microbiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Diagn Microbiol Infect Dis 65:214-6. 2009
    We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34...
  11. ncbi Transconjugation and genotyping of the plasmid-mediated AmpC beta-lactamase and extended-spectrum beta-lactamase genes in Klebsiella pneumoniae
    Wei feng Shi
    Department of Clinical Laboratory, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    Chin Med J (Engl) 122:1092-6. 2009
    ..ESBLs) are becoming predominant causes of resistance to third and forth-generation cephalosporins in Klebsiella pneumoniae (K. pneumoniae). It is very difficult to treat infectious diseases caused by multidrug-resistant K...
  12. pmc Molecular epidemiology of Klebsiella pneumoniae producing SHV-5 beta- lactamase: parallel outbreaks due to multiple plasmid transfer
    W M Prodinger
    Institut fur Hygiene, University of Innsbruck, Austria
    J Clin Microbiol 34:564-8. 1996
    ..were infected with extended-spectrum beta-lactamase-producing members of the family Enterobacteriaceae (30 Klebsiella pneumoniae isolates, 1 Klebsiella oxytoca isolate, and 1 Escherichia coli isolate)...
  13. ncbi Control of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a children's hospital by changing antimicrobial agent usage policy
    Jina Lee
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    J Antimicrob Chemother 60:629-37. 2007
    ..performed to examine the impact of a change in antibiotic policy on extended-spectrum beta-lactamase (ESBL) prevalence in a children's hospital with a high prevalence of ESBL production among Escherichia coli and Klebsiella pneumoniae.
  14. pmc Widespread dissemination of aminoglycoside resistance genes armA and rmtB in Klebsiella pneumoniae isolates in Taiwan producing CTX-M-type extended-spectrum beta-lactamases
    Ling Ma
    Division of Clinical Research, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan
    Antimicrob Agents Chemother 53:104-11. 2009
    Among 235 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL) isolates collected from a nationwide surveillance performed in Taiwan, 102 (43.4%) were resistant to amikacin. Ninety-two of these 102 (90...
  15. pmc Roles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae
    L Martinez-Martinez
    Department of Microbiology, School of Medicine, University of Seville, Seville, Spain
    Antimicrob Agents Chemother 43:1669-73. 1999
    Two clinical isolates of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem...
  16. pmc Diversity and evolution of the class A chromosomal beta-lactamase gene in Klebsiella pneumoniae
    S Haeggman
    Swedish Institute for Infectious Disease Control, SE 171 82 Solna, Sweden
    Antimicrob Agents Chemother 48:2400-8. 2004
    We investigated the diversity of the chromosomal class A beta-lactamase gene in Klebsiella pneumoniae in order to study the evolution of the gene...
  17. ncbi Phenotypic and molecular characterization of a novel beta-lactamase carried by Klebsiella pneumoniae, CTX-M-72, derived from CTX-M-3
    Jun Cheng
    Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China
    J Gen Appl Microbiol 55:207-16. 2009
    This study reports phenotypic and molecular characterization of a novel CTX-M beta-lactamase carried by two Klebsiella pneumoniae isolates collected from two hospitals in China...
  18. pmc Increased mortality and dysregulated cytokine production in tumor necrosis factor receptor 1-deficient mice following systemic Klebsiella pneumoniae infection
    Thomas A Moore
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Infect Immun 71:4891-900. 2003
    A significant clinical complication of pulmonary infections with Klebsiella pneumoniae is peripheral blood dissemination, resulting in a systemic infection concurrent with the localized pulmonary infection...
  19. pmc Predictors of mortality in patients with bloodstream infection due to ceftazidime-resistant Klebsiella pneumoniae
    Deverick J Anderson
    Duke University Medical Center, Division of Infectious Disease, DUMC Box 3824, Durham, NC 27710, USA
    Antimicrob Agents Chemother 50:1715-20. 2006
    ..identify predictors of in-hospital mortality among patients with BSI due to ceftazidime-resistant (CAZ-R) Klebsiella pneumoniae at a tertiary care medical center. Patients with CAZ-R K...
  20. pmc Effect of treatment duration on pharmacokinetic/pharmacodynamic indices correlating with therapeutic efficacy of ceftazidime in experimental Klebsiella pneumoniae lung infection
    Irma A J M Bakker-Woudenberg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Antimicrob Agents Chemother 50:2919-25. 2006
    ..PK/PD) indices that define the therapeutic effect of the beta-lactam ceftazidime in a rat model of Klebsiella pneumoniae lung infection were investigated in relation to treatment duration and treatment endpoint...
  21. ncbi [Surveillance of antimicrobial resistance among nosocomial gram-negative pathogens from 15 teaching hospitals in China in 2005]
    Qi Wen Yang
    Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 87:2753-8. 2007
    ..To investigate the antimicrobial resistance among the nosocomial gram-negative pathogens from 15 teaching hospitals located in different areas in China in 2005...
  22. ncbi Antibiotic-resistance patterns and frequency of extended-spectrum beta-lactamase-producing isolates of Klebsiella pneumoniae in Tehran
    Mohammad Mehdi Feizabadi
    Department of Microbiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
    Med Sci Monit 12:BR362-5. 2006
    Extended-spectrum beta-lactamase (ESBL)-producing strains of Klebsiella pneumoniae have caused major therapeutic problems worldwide since the majority are resistant to various antibiotics...
  23. ncbi Characterization of Klebsiella pneumoniae isolates from New Zealand sea lion (Phocarctos hookeri) pups during and after the epidemics on Enderby Island, Auckland Islands
    Aurelie Castinel
    New Zealand Wildlife Health Centre, IVABS, Massey University, Palmerston North, New Zealand
    Vet Microbiol 122:178-84. 2007
    ..b>Klebsiella pneumoniae was grown in pure culture from 83% of various organs and lesions in 2001/2002 and 76% in 2002/2003, and ..
  24. doi Characterization of plasmids encoding blaESBL and surrounding genes in Spanish clinical isolates of Escherichia coli and Klebsiella pneumoniae
    Karol Diestra
    Servicio de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Antimicrob Chemother 63:60-6. 2009
    The aim of the study was to characterize plasmids that harbour blaESBL genes and their genetic environment in Escherichia coli and Klebsiella pneumoniae clones circulating in Spain.
  25. ncbi Extended-spectrum beta-lactam resistance due to AmpC hyperproduction and CMY-2 coupled with the loss of OMPK35 in Malaysian strains of Escherichia coli and Klebsiella pneumoniae
    Selvi Palasubramaniam
    Department of Medical Microbiology, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Microb Drug Resist 13:186-90. 2007
    ..CMY-2 beta-lactamases with the loss of OmpK35 porin among seven sporadic strains of ceftazidime-resistant Klebsiella pneumoniae and ceftazidime-resistant Escherichia coli...
  26. doi Activity of ciprofloxacin and levofloxacin in experimental pneumonia caused by Klebsiella pneumoniae deficient in porins, expressing active efflux and producing QnrA1
    J M Rodríguez-Martínez
    Department of Microbiology, School of Medicine, University of Seville, Seville, Spain
    Clin Microbiol Infect 14:691-7. 2008
    ..was to evaluate the activities of ciprofloxacin and levofloxacin in a murine model of pneumonia caused by Klebsiella pneumoniae C2 (with altered GyrA, deficient in porins and expressing active efflux of quinolones) and the ..
  27. ncbi Extended spectrum beta-lactamase producing Escherichia coli and Klebsiella pneumoniae bacteremia. Risk factors and outcome in the eastern region of Saudi Arabia
    Javed I Memon
    Department of Medicine, King Abdulaziz National Guard Hospital, Al Ahsa, Kingdom of Saudi Arabia
    Saudi Med J 30:803-8. 2009
    To study the risk factors for bacteremia caused by Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae) producing extended-spectrum beta-lactamase (ESBL) and their outcome.
  28. ncbi Influence of third-generation cephalosporin utilization on the occurrence of ESBL-positive Klebsiella pneumoniae strains
    K Urbanek
    Department of Pharmacology, Faculty of Medicine and University Hospital, Olomouc, Czech Republic
    J Clin Pharm Ther 32:403-8. 2007
    b>Klebsiella pneumoniae belongs to important nosocomial pathogens causing mainly hospital-acquired infections. Beta-lactam antibiotics are frequently used in the treatment of infections caused by K...
  29. ncbi [Distribution and drug-resistance of 3 500 gram-negative bacteria in Guangzhou]
    Qing Zhong Xiao
    Clinical Laboratory, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China
    Di Yi Jun Yi Da Xue Xue Bao 25:132-8. 2005
    ..To investigate the distribution and drug-resistance of the common gram-negative bacteria in Guangzhou...
  30. pmc Regulation of nitrogenase synthesis in histidine auxotrophs of Klebsiella pneumoniae with altered levels of adenylate nucleotides
    J Stougaard
    Agricultural and Food Research Council, University of Sussex, Brighton, United Kingdom
    J Bacteriol 170:250-7. 1988
    A histidine auxotrophic (hisA) mutant of Klebsiella pneumoniae is phenotypically Nif- when grown with 20 micrograms of histidine ml-1 but Nif+ when supplied with histidine at 100 micrograms ml-1...
  31. ncbi In vitro binding of the response regulator CitB and of its carboxy-terminal domain to A + T-rich DNA target sequences in the control region of the divergent citC and citS operons of Klebsiella pneumoniae
    M Meyer
    Mikrobiologisches Institut, Eidgenossische Technische Hochschule, Zurich, Switzerland
    J Mol Biol 269:719-31. 1997
    The genes specifically required for citrate fermentation in Klebsiella pneumoniae form a cluster on the chromosome consisting of two divergently transcribed groups, citCDEFG and citS-oadGAB-citAB...
  32. pmc Characterization of the extended-spectrum beta-lactamase reference strain, Klebsiella pneumoniae K6 (ATCC 700603), which produces the novel enzyme SHV-18
    J K Rasheed
    Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 44:2382-8. 2000
    b>Klebsiella pneumoniae K6 (ATCC 700603), a clinical isolate, is resistant to ceftazidime and other oxyimino-beta-lactams...
  33. ncbi [Antimicrobial activity of soft and purified propolis extracts]
    Alvydas Pavilonis
    Department of Pharmaceutical Technology and Social Pharmacy, Kaunas University of Medicine, A Mickeviciaus 9, 44307 Kaunas, Lithuania
    Medicina (Kaunas) 44:977-83. 2008
    ..of Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 33499, Pseudomonas aeruginosa ATCC 27853, Proteus mirabilis ATCC 12459, Bacillus subtilis ATCC 6633, ..
  34. ncbi Prevalent phenotypes and antibiotic resistance in Escherichia coli and Klebsiella pneumoniae at an Indian tertiary care hospital: plasmid-mediated cefoxitin resistance
    M Shahid
    Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
    Int J Infect Dis 12:256-64. 2008
    ..Due to increased transcontinental movement of the human population, it would be wise to know the prevalence and resistance complexity of these strains, well in advance, in order to formulate a policy for empirical therapy...
  35. ncbi The nucleoside-specific Tsx channel from the outer membrane of Salmonella typhimurium, Klebsiella pneumoniae and Enterobacter aerogenes: functional characterization and DNA sequence analysis of the tsx genes
    A Nieweg
    Department of Biology, University of Konstanz, Germany
    Microbiology 143:603-15. 1997
    ..We cloned the structural genes of the Tsx proteins from Salmonella typhimurium, Klebsiella pneumoniae and Enterobacter aerogenes and expressed them in an E.coli tsx mutant...
  36. pmc Nosocomial blood stream infection in intensive care units at Assiut University Hospitals (Upper Egypt) with special reference to extended spectrum beta-lactamase producing organisms
    Shaaban H Ahmed
    Department of Public Health and Biostatistics, Faculty of Medicine, Assiut University, Assiut, Egypt
    BMC Res Notes 2:76. 2009
    ..outcome of infection, risk factors, prevalence of extended spectrum B-lactamase producing organisms and molecular typing of Klebsiella pneumoniae strains to highlight the role of environment as a potential source of nosocomial BSI.
  37. pmc Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein
    P A Bradford
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 41:563-9. 1997
    Six Escherichia coli and 12 Klebsiella pneumoniae isolates from a single hospital expressed a common beta-lactamase with a pI of approximately 9...
  38. doi Early diagnosis and therapeutic choice of Klebsiella pneumoniae liver abscess
    Jing Li
    Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
    Front Med China 4:308-16. 2010
    Nowadays, pyogenic liver abscess (PLA) is still a common and severe intra-abdominal infection, and Klebsiella pneumoniae had emerged as the most common pathogenic bacteria worldwide in the past ten years...
  39. doi Dissemination of the CTX-M-25 family beta-lactamases among Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae and identification of the novel enzyme CTX-M-41 in Proteus mirabilis in Israel
    Shiri Navon-Venezia
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Antimicrob Chemother 62:289-95. 2008
    ..We aimed to describe the occurrence and to understand the dissemination of this extended-spectrum beta-lactamase family among Enterobacteriaceae strains in our hospital...
  40. ncbi In vitro killing of parenteral beta-lactams against standard and high inocula of extended-spectrum beta-lactamase and non-ESBL producing Klebsiella pneumoniae
    David S Burgess
    College of Pharmacy, University of Texas at Austin, Austin, TX, USA
    Diagn Microbiol Infect Dis 49:41-6. 2004
    Minimum inhibitory concentrations and time-kill curves were performed against 8 Klebsiella pneumoniae (4 non-extended-spectrum beta-lactamase[ESBL] and 4 ESBL) for piperacillin/tazobactam (40/5 microg/mL), cefepime (20 microg/mL), and ..
  41. doi Extended-spectrum beta-lactamase producing Klebsiella pneumoniae in neonatal intensive care unit
    H Abdel-Hady
    Neonatal Care Unit, Mansoura University Children s Hospital, Mansoura, Egypt
    J Perinatol 28:685-90. 2008
    Extended-spectrum beta-lactamase producing (ESBL) Klebsiella pneumoniae is an important cause of nosocomial infections in neonatal intensive care units (NICUs). Our objectives were to determine (1) the incidence of ESBL K...
  42. ncbi Beta-glucoside kinase (BglK) from Klebsiella pneumoniae. Purification, properties, and preparative synthesis of 6-phospho-beta-D-glucosides
    John Thompson
    Microbial Biochemistry and Genetics Unit, Oral Infection and Immunity Branch, NIDCR National Institutes of Health, 30 Convent Drive, MSC 4350, Bethesda, MD 20892, USA
    J Biol Chem 277:34310-21. 2002
    ATP-dependent beta-glucoside kinase (BglK) has been purified from cellobiose-grown cells of Klebsiella pneumoniae. In solution, the enzyme (EC ) exists as a homotetramer composed of non-covalently linked subunits of M(r) approximately 33,..
  43. ncbi Phenotypic characteristics of clinical isolates of Klebsiella pneumoniae & evaluation of available phenotypic techniques for detection of extended spectrum beta-lactamases
    Vikas Manchanda
    Department of Microbiology, University College of Medical Sciences and Guru Tegh Bahadur Hospital, University of Delhi, Delhi, India
    Indian J Med Res 122:330-7. 2005
    ..present study was undertaken to evaluate phenotypic characteristics, initial screening tests and established confirmatory phenotypic methods for detection of ESBLs Klebsiella pneumoniae isolates prevalent in a hospital in north India.
  44. ncbi Ongoing epidemic of blaVIM-1-positive Klebsiella pneumoniae in Athens, Greece: a prospective survey
    M Psichogiou
    First Department of Propaedeutic Medicine, Medical School, University of Athens, Athens, Greece
    J Antimicrob Chemother 61:59-63. 2008
    To determine the current frequency and study the characteristics of VIM-1-producing Klebsiella pneumoniae isolates from bloodstream infections in Greek hospitals.
  45. doi Clonal spread of CTX-M-15-producing Klebsiella pneumoniae in a Croatian hospital
    Mirna Vranic-Ladavac
    County of Istria Public Health Institute, Nazorova 23, Pula, Croatia
    J Med Microbiol 59:1069-78. 2010
    ..was conducted to detect and analyse the presence of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae associated with a nosocomial outbreak at a Croatian hospital. During 2007, 162 K...
  46. ncbi Metabolism of sucrose and its five linkage-isomeric alpha-D-glucosyl-D-fructoses by Klebsiella pneumoniae. Participation and properties of sucrose-6-phosphate hydrolase and phospho-alpha-glucosidase
    J Thompson
    Microbial Biochemistry and Genetics Unit, Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:37415-25. 2001
    b>Klebsiella pneumoniae is presently unique among bacterial species in its ability to metabolize not only sucrose but also its five linkage-isomeric alpha-d-glucosyl-d-fructoses: trehalulose, turanose, maltulose, leucrose, and palatinose...
  47. ncbi Multidrug-resistant bacteria in hospitalized children: a 5-year multicenter study
    Josette Raymond
    Service de Bacteriologie, Hopital Cochin Saint Vincent de Paul, 27 rue du Faubourg Saint Jacques, 75679 Paris Cedex 14, France
    Pediatrics 119:e798-803. 2007
    ..The objective of this study was to determine the incidence of multidrug-resistant bacteria in hospitalized children...
  48. pmc Klebsiella pneumoniae multiresistance plasmid pMET1: similarity with the Yersinia pestis plasmid pCRY and integrative conjugative elements
    Alfonso J C Soler Bistué
    Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Science and Mathematics, California State University Fullerton, Fullerton, California, United States of America
    PLoS ONE 3:e1800. 2008
    ..Dissemination of antimicrobial resistance genes has become an important public health and biodefense threat. Plasmids are important contributors to the rapid acquisition of antibiotic resistance by pathogenic bacteria...
  49. doi Spread of plasmids containing the bla(VIM-1) and bla(CTX-M) genes and the qnr determinant in Enterobacter cloacae, Klebsiella pneumoniae and Klebsiella oxytoca isolates
    Elisenda Miro
    Servei de Microbiologia, Hospital de Sant Pau, Barcelona, Spain
    J Antimicrob Chemother 65:661-5. 2010
    We describe 12 VIM-1-producing strains (7 Enterobacter cloacae, 2 Klebsiella pneumoniae and 3 clonal Klebsiella oxytoca strains) detected among clinically relevant Enterobacteriaceae isolates from routine cultures at the Hospital del Mar ..
  50. ncbi Emergence and prevalence of beta-lactamase-producing Klebsiella pneumoniae resistant to cephems in Japan
    Tetsuro Muratani
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Int J Antimicrob Agents 27:491-9. 2006
    Forty-six cephem-resistant Klebsiella pneumoniae strains with minimum inhibitory concentrations>8 microg/mL for cefpodoxime and cefmetazole were selected from clinical isolates obtained between 2000 and 2002 from eight hospitals on ..
  51. pmc Plasmid-mediated AmpC-type beta-lactamase isolated from Klebsiella pneumoniae confers resistance to broad-spectrum beta-lactams, including moxalactam
    T Horii
    Department of Bacteriology, Nagoya University School of Medicine, Japan
    Antimicrob Agents Chemother 37:984-90. 1993
    b>Klebsiella pneumoniae NU2936 was isolated from a patient and was found to produce a plasmid-encoded beta-lactamase (MOX-1) which conferred resistance to broad spectrum beta-lactams, including moxalactam, flomoxef, ceftizoxime, cefotaxime,..
  52. pmc Complex regulation of urease formation from the two promoters of the ure operon of Klebsiella pneumoniae
    Qiong Liu
    Department of Molecular Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109 1048, USA
    J Bacteriol 189:7593-9. 2007
    b>Klebsiella pneumoniae can use urea as the sole source of nitrogen, thanks to a urease encoded by the ureDABCEFG operon. Expression of this operon is independent of urea and is regulated by the supply of nitrogen in the growth medium...
  53. doi Expansion and countrywide dissemination of ST11, ST15 and ST147 ciprofloxacin-resistant CTX-M-15-type beta-lactamase-producing Klebsiella pneumoniae epidemic clones in Hungary in 2005--the new 'MRSAs'?
    Ivelina Damjanova
    Department of Phage Typing and Molecular Epidemiology, National Center for Epidemiology, Gyali ut 2 6, 1097 Budapest, Hungary
    J Antimicrob Chemother 62:978-85. 2008
    To investigate the molecular epidemiology of ciprofloxacin-resistant CTX-M-15-producing Klebsiella pneumoniae epidemic clones (ECs) isolated from six nosocomial outbreaks and sporadic cases during 2005 in Hungary.
  54. pmc Nucleotide binding by the nitrogenase Fe protein: a 31P NMR study of ADP and ATP interactions with the Fe protein of Klebsiella pneumoniae
    R W Miller
    The Nitrogen Fixation Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, U K
    Biochem J 334:601-7. 1998
    Investigation of the interaction of MgADP- and MgATP2- with the Fe protein of Klebsiella pneumoniae nitrogenase by 31P NMR showed that the adenine nucleotides are reversibly bound in slow exchange with free nucleotides...
  55. pmc High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae
    L B Rice
    Medical Service, Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 44:362-7. 2000
    We describe Klebsiella pneumoniae 15571, a clinical isolate resistant to ceftazidime MIC = 32 microg/ml) and piperacillin-tazobactam (MICs = 1,024 and 128 microg/ml). K. pneumoniae 15571 expresses a single beta-lactamase with a pI of 7.6...
  56. ncbi Ceftazidime-resistant Klebsiella pneumoniae bloodstream infection in children with febrile neutropenia
    H Ariffin
    Department of Paediatrics and Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
    Int J Infect Dis 4:21-5. 2000
    To evaluate prevalence of ceftazidime-resistant Klebsiella pneumoniae (CRKP) in the pediatric oncology unit of University Hospital, Kuala, Lumpur, and to identify differences between febrile neutropenic pediatric patients with CRKP and ..
  57. ncbi Epidemic and endemic spread of Klebsiella pneumoniae producing SHV-5 beta-lactamase in Dubrava University Hospital, Zagreb, Croatia
    B Bedenic
    Department of Microbiology, A Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia
    J Chemother 17:367-75. 2005
    ..In a previous study conducted during 1994-1995, SHV-2, SHV-2a and SHV-5 beta-lactamases were found among Klebsiella pneumoniae isolates in Dubrava University Hospital. High prevalence of ESBLs among K...
  58. ncbi Clarithromycin is an effective immunomodulator in experimental pyelonephritis caused by pan-resistant Klebsiella pneumoniae
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece
    J Antimicrob Chemother 57:937-44. 2006
    To apply clarithromycin as an immunomodulatory treatment in experimental infection caused by pan-resistant Klebsiella pneumoniae.
  59. ncbi Selection of Klebsiella pneumoniae mutants with high-level cefotaxime resistance during growth in serum containing therapeutic concentrations of cefotaxime
    Branka Bedenic
    Department of Microbiology, A Stampar School of Public Health, Medical School, University of Zagreb, Croatia
    Chemotherapy 48:10-4. 2002
    In a previous investigation of the genetic characterization of extended-spectrum beta-lactamases (ESBLs) in Klebsiella pneumoniae from Zagreb, Croatia, 20 strains were found to produce SHV-2 beta-lactamase...
  60. pmc Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital
    Jia Chang Cai
    2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
    Antimicrob Agents Chemother 52:2014-8. 2008
    Twenty-one Serratia marcescens, ten Klebsiella pneumoniae, and one Escherichia coli isolate with carbapenem resistance or reduced carbapenem susceptibility were recovered from intensive care units (ICUs) in our hospital...
  61. pmc Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials
    C Hal Jones
    Wyeth Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 53:465-75. 2009
    ..the genes responsible for the extended-spectrum-beta-lactamase (ESBL) phenotypes of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during the global tigecycline phase 3 clinical trials...
  62. pmc Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital
    Thomas D Gootz
    Department of Infectious Diseases, Pfizer Global Research and Development, Groton, CT 06340, USA
    Antimicrob Agents Chemother 53:1998-2004. 2009
    Carbapenem-resistant Klebsiella strains carrying Klebsiella pneumoniae carbapenemases (KPC) are endemic to New York City and are spreading across the United States and internationally...
  63. pmc Characterization of CTX-M ESBLs in Enterobacter cloacae, Escherichia coli and Klebsiella pneumoniae clinical isolates from Cairo, Egypt
    Noha G Khalaf
    Department of Microbiology and Immunology, Faculty of Pharmacy Helwan University, Helwan, Egypt
    BMC Infect Dis 9:84. 2009
    ..This study aims to characterize the resistance mechanism (s) to extended spectrum cephalosporins among resistant clinical isolates at a medical institute in Cairo, Egypt...
  64. pmc Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells
    David Moranta
    Program Infection and Immunity, Fundación Caubet CIMERA Illes Balears, Recinto Hospital Joan March, 07110 Bunyola, Spain
    Infect Immun 78:1135-46. 2010
    ..It is reasonable to postulate that pathogens have developed countermeasures to resist them. Klebsiella pneumoniae capsule polysaccharide (CPS), but not the lipopolysaccharide O antigen, mediated resistance against hBD1 ..
  65. pmc Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri
    Y Yang
    Wyeth Ayerst Research, Pearl River, New York 10965, USA
    Antimicrob Agents Chemother 42:1671-6. 1998
    Ceftazidime-resistant Escherichia coli and Klebsiella pneumoniae (49 and 102 isolates, respectively) were collected from Barnes-Jewish Hospital, St. Louis, Mo., from 1992 to 1996...
  66. ncbi Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping
    S Brisse
    Eijkman Winkler Institute, University Medical Centre Utrecht, The Netherlands
    Int J Syst Evol Microbiol 51:915-24. 2001
    The infra-specific phylogenetic diversity and genetic structure of both Klebsiella pneumoniae and Klebsiella oxytoca was investigated using a combination of randomly amplified polymorphic DNA (RAPD) analysis, sequencing of gyrA and parC ..
  67. pmc Mutations which uncouple transport and phosphorylation in the D-mannitol phosphotransferase system of Escherichia coli K-12 and Klebsiella pneumoniae 1033-5P14
    Susanne Otte
    Fachbereich Biologie chemie, Universitat Osnabruck, D 49069 Osnabruck, Germany
    J Bacteriol 185:2267-76. 2003
    ..coli K-12 or from Klebsiella pneumoniae 1033-5P14...
  68. pmc Effects of inoculum and beta-lactamase activity in AmpC- and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates tested by using NCCLS ESBL methodology
    Anne Marie Queenan
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Raritan, New Jersey 08869, USA
    J Clin Microbiol 42:269-75. 2004
    Escherichia coli and Klebsiella pneumoniae isolates with extended-spectrum beta-lactamases (ESBLs) or AmpC cephalosporinases generally respond as predicted to NCCLS tests for ESBL production. However, inoculum size may affect MICs...
  69. ncbi Linkage of ciprofloxacin resistance with a single genotypic cluster of Klebsiella pneumoniae
    A A Dashti
    Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Health Science Center, Kuwait University, Sulabikhat
    Int J Antimicrob Agents 27:73-6. 2006
    ..to examine the epidemiology of ciprofloxacin-resistant, extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae strains. Sixty-nine unique patient isolates of K...
  70. ncbi Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess
    Chi Tai Fang
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Infect Dis 45:284-93. 2007
    Since 1986, researchers have noted a syndrome of Klebsiella pneumoniae pyogenic liver abscess that is complicated by endophthalmitis or central nervous system infections...
  71. doi Predictors of septic metastatic infection and mortality among patients with Klebsiella pneumoniae liver abscess
    Susan Shin Jung Lee
    Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    Clin Infect Dis 47:642-50. 2008
    Primary liver abscess caused by Klebsiella pneumoniae is an infection that is emerging worldwide and that is associated with severe morbidity and considerable mortality.
  72. pmc Use of a Dictyostelium model for isolation of genetic loci associated with phagocytosis and virulence in Klebsiella pneumoniae
    Yi Jiun Pan
    Department of Microbiology, National Taiwan University College of Medicine, 1, Sec 1, Jen Ai Rd, Taipei 10051, Taiwan
    Infect Immun 79:997-1006. 2011
    Phagocytosis resistance is an important virulence factor in Klebsiella pneumoniae. Dictyostelium has been used to study the interaction between phagocytes and bacteria because of its similarity to mammalian macrophages...
  73. doi Molecular epidemiology and resistance mechanisms involved in reduced susceptibility to amoxicillin/clavulanic acid in Klebsiella pneumoniae isolates from a chronic care centre
    Mar Olga Pérez-Moreno
    Servei Anàlisis Clíniques, Hospital de Tortosa Verge de la Cinta, C Esplanetes s n 43500 Tortosa, Spain
    Int J Antimicrob Agents 37:462-6. 2011
    ..responsible for reduced susceptibility to amoxicillin/clavulanic acid (AMC) amongst cefazolin-susceptible Klebsiella pneumoniae isolates from patients admitted to a chronic care institution. In total, 51 (29.8%) of 171 K...
  74. pmc Klebsiella pneumoniae outer membrane porins OmpK35 and OmpK36 play roles in both antimicrobial resistance and virulence
    Yu Kuo Tsai
    Division of Infectious Diseases, National Health Research Institutes, Miaoli, Taiwan
    Antimicrob Agents Chemother 55:1485-93. 2011
    OmpK35 and OmpK36 are the major outer membrane porins of Klebsiella pneumoniae. In this study, a virulent clinical isolate was selected to study the role of these two porins in antimicrobial resistance and virulence...
  75. ncbi Activity of antibacterial impregnated central venous catheters against Klebsiella pneumoniae
    Kaya Yorganci
    Hacettepe University, Faculty of Medicine, Department of General Surgery, Ankara, Turkey
    Intensive Care Med 28:438-42. 2002
    ..The aim of this study was to evaluate and compare the adherence, persistence and colonization of Klebsiella pneumoniae on catheter surfaces and also to assess bacteriostatic and bactericidal levels.
  76. ncbi [Investigation of CTX-M type beta-lactamases in Klebsiella pneumoniae clinical isolates by phenotypic and molecular methods]
    Soner Tikvesli
    Silopi Devlet Hastanesi, Mikrobiyoloji Laboratuvani, Sirnak
    Mikrobiyol Bul 43:553-62. 2009
    ..The aim of this study was to investigate the presence of CTX-M type ESBL in Klebsiella pneumoniae clinical strains by phenotypic and molecular methods. A total of 217 non-repetitive K...
  77. doi Phenotypic and genotypic characterization of β-lactam resistance in Klebsiella pneumoniae isolated from swine
    Li Kou Zou
    School of Life Science, Sichuan University, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, China
    Vet Microbiol 149:139-46. 2011
    Little is known about the antimicrobial resistance mechanisms in Klebsiella pneumoniae from swine in China. Thus, this paper aims to demonstrate the β-lactam resistance phenotypes and genotypes of K...
  78. ncbi [Relationship between isolation of extended spectrum beta-lactamase-producing Klebsiella pneumoniae and course of hospital-acquired pneumonia]
    Astra Vitkauskiene
    Institute for Biomedical Research, Laboratory of Microbiology, Kaunas University of Medicine, Lithuania
    Medicina (Kaunas) 43:778-83. 2007
    To evaluate relationship between isolation of extended spectrum beta-lactamase-producing Klebsiella pneumoniae strains and course of hospital-acquired pneumonia.
  79. doi Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug-resistant epidemic Klebsiella pneumoniae strain
    Azita Leavitt
    Molecular Epidemiology and Antimicrobial Resistance Laboratory, Division of Epidemiology, Tel Aviv Medical Center, Tel Aviv, Israel
    J Antimicrob Chemother 65:243-8. 2010
    An extremely drug-resistant (XDR) clone of KPC-3-producing Klebsiella pneumoniae emerged in Israel in 2006, causing a nationwide outbreak...
  80. pmc Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase production
    Luis Martinez-Martinez
    Department of Microbiology, School of Medicine, University of Seville, Spain
    Antimicrob Agents Chemother 46:3926-32. 2002
    ..and extended-spectrum beta-lactamase (ESBL) production were determined for 53 clinical isolates of Klebsiella pneumoniae. Thirty-two ESBL-positive strains (including 22 strains expressing porins and 10 strains lacking porins) ..
  81. ncbi An accelerated method for the detection of extended-spectrum beta-lactamases in urinary isolates of Escherichia coli and Klebsiella pneumoniae
    Abdulrahman A Kader
    Department of Clinical Microbiology, Almana General Hospital, Al Khobar, Saudi Arabia
    Saudi J Kidney Dis Transpl 17:535-9. 2006
    ..coli) and Klebsiella pneumoniae (K. pneumoniae)...
  82. doi First detection of CTX-M-28 in a Tunisian hospital from a cefotaxime-resistant Klebsiella pneumoniae strain
    N Ben Achour
    Laboratoire de Biochimie et de Technobiologie, Faculte des Sciences de Tunis, Campus Universitaire, 2092 EL MANAR II, Tunisia
    Pathol Biol (Paris) 57:343-8. 2009
    A cefotaxime-resistant Klebsiella pneumoniae ML4313 was obtained from a patient from intensive care unit of Military hospital in Tunisia...
  83. doi Production of (2S,3S)-2,3-butanediol and (3S)-acetoin from glucose using resting cells of Klebsiella pneumonia and Bacillus subtilis
    Zhen Liu
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, People s Republic of China
    Bioresour Technol 102:10741-4. 2011
    ..study, glucose was first transformed to a mixture of (2S,3S)-2,3-BD and meso-2,3-BD by resting cells of Klebsiella pneumoniae CICC 10011, followed by biocatalytic resolution of the mixture by resting cells of Bacillus subtilis 168...
  84. doi Fermentation and evaluation of Klebsiella pneumoniae and K. oxytoca on the production of 2,3-butanediol
    Jung Hee Cho
    Research and Development Center, GS Caltex Corporation, Yusung Gu, Daejeon, Republic of Korea
    Bioprocess Biosyst Eng 35:1081-8. 2012
    ..pneumoniae showed higher productivity, SEM showed that it secreted large amounts of capsular polysaccharide, increasing pathogenicity and hindering the separation of cells from the fermentation broth during downstream processing...
  85. ncbi [Endogenous endophthalmitis and meningo-encephalitis in septic bacteremia of Klebsiella pneumoniae]
    Masahiko Ohta
    Division of Neurology, Hyogo Prefectural Amagasaki Hospital
    Rinsho Shinkeigaku 53:37-40. 2013
    ..A 69-year-old compromised adult abruptly developed septic bacteremia and meningo-encephalitis by Klebsiella pneumoniae. After an improvement from initial conscious disturbance and systemic inflammatory unstable vital ..
  86. pmc BLIP-II is a highly potent inhibitor of Klebsiella pneumoniae carbapenemase (KPC-2)
    Nicholas G Brown
    Department of Biochemistry and Molecular Biology and Department of Pharmacology, Baylor College of Medicine, Houston, Texas, USA
    Antimicrob Agents Chemother 57:3398-401. 2013
    ..Determination of association and dissociation rate constants for binding between BLIP-II and KPC-2 reveals a very tight interaction with a calculated (koff/kon) equilibrium dissociation constant of 76 fM (76 × 10(-15) M)...
  87. pmc Host-defense peptides with therapeutic potential from skin secretions of frogs from the family pipidae
    J Michael Conlon
    Department of Biochemistry, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE
    Pharmaceuticals (Basel) 7:58-77. 2014
    ..of Staphylococcus aureus, Escherichia coli, Acinetobacter baumannii, Stenotrophomonas maltophilia and Klebsiella pneumoniae. Despite this, the therapeutic potential of frog skin peptides as anti-infective agents has not been ..
  88. doi Extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae bacteremia in febrile neutropenic children
    Seung Beom Han
    1 Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    Microb Drug Resist 21:244-51. 2015
    ..outcomes of bacteremia caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae and their antibiotic susceptibilities in febrile neutropenic children...
  89. doi Diversity, antimicrobial and antioxidant activities of culturable bacterial endophyte communities in Aloe vera
    Mushafau Adewale Akinsanya
    School of Science, Monash University Malaysia, Jalan Lagoon Selatan, 46150 Bandar Sunway, Selangor, Malaysia Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Lagos State University, Oba Akinjobi Street, Ikeja, Lagos, Nigeria
    FEMS Microbiol Lett 362:fnv184. 2015
    ..Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Salmonella Typhimurium, Proteus vulgaris, Klebsiella pneumoniae, Escherichia coli, Streptococcus pyogenes and Candida albicans, with inhibition zones ranging from 6...
  90. doi γ-Cyclodextrin capped silver nanoparticles for molecular recognition and enhancement of antibacterial activity of chloramphenicol
    Ramesh Gannimani
    Department of Biochemistry, School of Life Sciences, University of KwaZulu Natal UKZN, Westville, Durban 4000, South Africa
    J Inorg Biochem 157:15-24. 2016
    ..was evaluated against Pseudomonas aeruginosa (ATCC 27853), Enterococcus faecalis (ATCC 5129), Klebsiella pneumoniae (ATCC 700603) and Staphylococcus aureus (ATCC 43300)...
  91. pmc Initial Assessment of the Molecular Epidemiology of blaNDM-1 in Colombia
    Laura J Rojas
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 60:4346-50. 2016
    ..typing (MLST) revealed that these isolates belong to sequence type 10 (ST10) (Escherichia coli), ST392 (Klebsiella pneumoniae), and ST322 and ST464 (Acinetobacter baumannii and Acinetobacter nosocomialis, respectively)...
  92. pmc Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway
    Katherine A Hicks
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
    Acta Crystallogr D Struct Biol 72:808-16. 2016
    HpxW from the ubiquitous pathogen Klebsiella pneumoniae is involved in a novel uric acid degradation pathway downstream from the formation of oxalurate...
  93. pmc A novel multicopy suppressor of a groEL mutation includes two nested open reading frames transcribed from different promoters
    T Greener
    Biochemistry Department, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 12:889-96. 1993
    ..A groEL mutant of E.coli, transformed with the Klebsiella pneumoniae nif gene cluster, failed to accumulate nitrogenase components [Govezensky et al. (1991) J. Bacteriol...
  94. pmc Outer membrane profiles of clonally related Klebsiella pneumoniae isolates from clinical samples and activities of cephalosporins and carbapenems
    C Ardanuy
    Servicio de Microbiologia, Hospital de Bellvitge, Universidad de Barcelona, Spain
    Antimicrob Agents Chemother 42:1636-40. 1998
    Fifteen isolates of Klebsiella pneumoniae producing extended-spectrum beta-lactamases (ESBLs) isolated during a nosocomial outbreak were studied...
  95. pmc Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae
    L Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, France
    Antimicrob Agents Chemother 44:622-32. 2000
    b>Klebsiella pneumoniae ORI-1 was isolated in 1998 in France from a rectal swab of a 1-month-old girl who was previously hospitalized in Cayenne Hospital, Cayenne, French Guiana. This strain harbored a ca...
  96. pmc In vitro and in vivo antibacterial activities of L-084, a novel oral carbapenem, against causative organisms of respiratory tract infections
    S Miyazaki
    Department of Microbiology, Toho University School of Medicine, Tokyo, Japan
    Antimicrob Agents Chemother 45:203-7. 2001
    ..staphylococci, Streptococcus pneumoniae including penicillin-resistant organisms, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae including ampicillin-resistant organisms, Legionella pneumophila, and Moraxella ..
  97. pmc Macrophage inflammatory protein 1alpha/CCL3 is required for clearance of an acute Klebsiella pneumoniae pulmonary infection
    D M Lindell
    Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 69:6364-9. 2001
    ..was to determine the role of macrophage inflammatory protein 1alpha/CCL3 in pulmonary host defense during Klebsiella pneumoniae infection...
  98. ncbi Alternative arrangements of catalytic residues at the active sites of restriction enzymes
    Gintautas Tamulaitis
    Institute of Biotechnology, Graiciuno 8, 2028, Vilnius, Lithuania
    FEBS Lett 518:17-22. 2002
    ....
  99. ncbi N-butanoyl-L-homoserine lactone (BHL) deficient Pseudomonas aeruginosa isolates from an intensive care unit
    Gulgun Bosgelmez-Tinaz
    Department of Biology, Suleyman Demirel University, 32260 Isparta, Turkey
    Microbiol Res 160:399-403. 2005
    ..In this study, strains of Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli and Klebsiella pneumoniae, isolated from intensive care patients, were screened for AHL production by using AHL responsive indicator ..
  100. ncbi Extended spectrum beta-lactamase producing Enterobacteriaceae in Lebanese ICU patients: epidemiology and patterns of resistance
    Ziad Daoud
    Department of Laboratory Medicine, Saint George University Hospital, Beirut, Lebanon
    J Gen Appl Microbiol 52:169-78. 2006
    ..5%) E. coli, 16 (13.6%) Klebsiella pneumoniae, and 7 (5.6%) Enterobacter cloacae...
  101. doi Risk factors for colonisation of newborn infants during an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in an intermediate-risk neonatal unit
    V C Cassettari
    Hospital Infection Control Committee, Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil
    J Hosp Infect 71:340-7. 2009
    ..to identify risk factors for colonisation of neonates by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae. This occurred following exposure to a colonised healthcare worker during an outbreak in an intermediate-..

Research Grants64

  1. Detecting Carbapenem and Quinolone Resistance in Klebsiella pneumoniae using PCR/
    Robert A Bonomo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Among Gram-negative bacteria, nosocomial infections by Klebsiella pneumoniae that are resistant to carbapenems and quinolones are rapidly becoming a global problem...
  2. Robert A Bonomo; Fiscal Year: 2014
    ..These [unreadable]-lactamases are found in ceftazidime resistant Klebsiella pneumoniae, Escherichia coli, Enterobacter spp., Acinetobacter baumannii, and Pseudomonas aeruginosa...
  3. Multi-Drug Resistant Urinary Tract Infections in Ambulatory Settings
    Ebbing Lautenbach; Fiscal Year: 2012
    ..g., Escherichia coli, Klebsiella pneumoniae) have been noted over the past decade...
  4. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..resistant (MDR) Gram-negative bacteria including Pseudomonas aeruginosa, Acinetobacter species, and Klebsiella pneumoniae are emerging pathogens that are increasingly the cause of a variety of serious infections in hospitalized ..
  5. Gamma Delta T Cells in Anti-Bacterial Host Defense
    Thomas Moore; Fiscal Year: 2005
    b>Klebsiella pneumoniae is a leading cause of community-acquired and nosocomial infections. Moreover, K pneumoniae is the second leading cause of nosocomial gram negative bacteremia...
  6. National surveillance of emerging MDR in pediatric Enterobacteriaceae infections
    Danielle M Zerr; Fiscal Year: 2013
    ..We propose to study antibiotic resistance in Enterobacteriaceae bacteria (such as Escherichia coli and Klebsiella pneumoniae) that produce urinary tract and bloodstream infections in children, by analyzing clinical isolates from 4 ..
  7. Molecular Archaeology: Vintage Beta Lactams for Resistant Gram Negative Infectio
    Marvin J Miller; Fiscal Year: 2013
    ..stable to most Class A and Class C beta-lactamases, are susceptible to Class B enzymes as well as emerging Klebsiella pneumoniae carbapenemase (KPC) Class A enzymes...
  8. Redesign of the Carbapenem Scaffold
    Bret M Benton; Fiscal Year: 2012
    ..of both carbapenem-susceptible as well as carbapenem-resistant strains, including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii isolates...
  9. Differences in infecting and colonizing Enterobacteriaceae from short-course vs s
    Scott J Weissman; Fiscal Year: 2013
    ..proportions of children with gastrointestinal colonization by antibiotic-resistant Escherichia coli and/or Klebsiella pneumoniae. Thus, subjects will have stool samples obtained for bacterial culture at enrollment visit (#1;day 4-6) ..
  10. Identification of genes essential for survival of hypervirulent Kleb. pneumoniae
    Thomas A Russo; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): A new, hypervirulent clinical variant of Klebsiella pneumoniae (hvKP) has emerged over the last decade...
  11. The molecular basis of epidemic blaKPC Klebsiella pneumoniae and Enterobacteriace
    BARRY NEAL KREISWIRTH; Fiscal Year: 2010
    ..provided by applicant): Recent reports indicating a rise in infections caused by carbapenem-resistant Klebsiella pneumoniae (KPC) in the United States and elsewhere have alerted clinicians, infection control teams and public ..
  12. Robert A Bonomo; Fiscal Year: 2016
    ..carbapenemases are emerging in Klebsiella and are a major threat to our antibiotic armamentarium: the Klebsiella pneumoniae carbapenemase (KPC-2), and the New Delhi Metallo-[unreadable]-lactamase (NDM-1 MBL)...
  13. Design of antituberculosis agents that target siderophore biosynthesis
    Courtney C Aldrich; Fiscal Year: 2013
    ..will be on the organism Mycobacterium tuberculosis;however, the Gram-negative Acinetobacter baumannii and Klebsiella pneumoniae will also be pursued...
  14. Innovative technologies to effectively treat Multi-drug resistant and/or biofilm-
    Jie Wen; Fiscal Year: 2010
    ..confirmed the emergence of multi-drug resistant bacteria (MDR) such as Acinetobacter baumannii, Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus, and multi-drug resistant Pseudomonas aeruginosa...
  15. Exploiting deep ocean biology for biomedical discovery
    David C Rowley; Fiscal Year: 2011
    ..resistant Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae. Thus, this project will focus on finding antibiotics against the most problematic clinical pathogens...
  16. RmpA, a unique virulence regulator in emerging Klebsiella pneumoniae
    Valley J Stewart; Fiscal Year: 2012
    ..Although relatively little-studied, Klebsiella pneumoniae nevertheless is a notorious nosocomial pathogen responsible for widespread dissemination of antibiotic ..
  17. Optimization of novel pyranopyridine efflux pump inhibitors
    Son Truong Nguyen; Fiscal Year: 2013
    ..antibiotics against Escherichia coli, Shigella flexneri, Salmonella enterica, Enterobacter cloacae, and Klebsiella pneumoniae by inhibiting the major efflux pump in these organisms (AcrA-AcrB-TolC)...
  18. BARRY NEAL KREISWIRTH; Fiscal Year: 2015
    ..provided by applicant): Recent reports indicating a rise in infections caused by carbapenem- resistant Klebsiella pneumoniae (KPC) in the United States, specifically the New York metropolitan area, and elsewhere have alerted ..
  19. KARL A DRLICA; Fiscal Year: 2014
    ..However, co-treatment of E. coli, Klebsiella pneumoniae, and Acinetobacter baumannii with bicyclomycin plus a second inhibitor of gene expression (e.g...
  20. Brad J Spellberg; Fiscal Year: 2014
    ..For example, infections caused by XDR, KPC-expressing Klebsiella pneumoniae have spread across the US and are associated with a 50% mortality rate...
  21. REGULATION BY THE ESCHERICHIA COLI SMALL RNA, DSRA
    DARREN SLEDJESKI; Fiscal Year: 2002
    DsrA is a small, stable, untranslated RNA that is conserved between Escherichia coli, Klebsiella pneumoniae, and Salmonella typhimurium. DsrA RNA regulates two different global regulatory networks...
  22. Jian Li; Fiscal Year: 2016
    ..of infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, Enterobacter species, Enterococcus faecium and Staphyloccocus aureus...
  23. Samithamby Jeyaseelan; Fiscal Year: 2016
    ..As a model to elucidate the basic host defense mechanisms, we have focused on a primary pathogen, Klebsiella pneumoniae because this extracellular Gram-negative bacterium causes severe pneumonia;and the extensive spread of ..
  24. Michael J Solomon; Fiscal Year: 2016
    ..Staphylococcus epidermidis and Klebsiella pneumoniae are common causes of intravascular catheter infection, in part due to their production of biofilms that ..
  25. Novel Vaccines To Evoke Bladder Mucosal Immunity
    David J Klumpp; Fiscal Year: 2010
    ..of community-acquired UTIs, but diverse bacteria such as Proteus mirabilis, Pseudomonas aeruginosa, and Klebsiella pneumoniae are often associated with complicated UTIs...
  26. Roles of IL-17-induced gene expression in airway epithelial host defense
    Reen Wu; Fiscal Year: 2013
    ..To test this hypothesis, the well-established Klebsiella pneumoniae and the clinically relevant Pseudomonas aeruginosa infection mouse models will be used...
  27. POINT OF CARE DIAGNOSTICS FOR URINARY TRACT INFECTION
    KUMAR SUBRAMANIAN; Fiscal Year: 2012
    ..During PHASE II we will expand the menu to include for the detection of other organisms including Klebsiella pneumoniae, Proteus mirabilis, Enterococcus sp., Pseudomonas aeruginosa...
  28. The Use of Polyamines in Treatment of Multidrug-Resistant Gram-Negative Pathogens
    Dong Hyeon Kwon; Fiscal Year: 2013
    ..pathogens associated healthcare-infections and nosocomial outbreaks are Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii...
  29. Molecular Pathogenesis of Klebsiella Pneumoniae
    Steven Clegg; Fiscal Year: 2010
    b>Klebsiella pneumoniae is an opportunistic pathogen frequently implicated in respiratory and urinary tract infections of hospitalized patients...
  30. DnaK Protein Inhibitor Antimicrobials
    Michael Sturgess; Fiscal Year: 2003
    ..pyrrhocoricin analog is currently studied for its ability to protect mice against systemic and local Klebsiella pneumoniae, Escherichia coli, Haemophilus influenzae, Moraxella catarrhalis and Salmonella typhimurium infections...
  31. IL-23 / Il-17 and Lung Host Defense
    Jay Kolls; Fiscal Year: 2009
    ..Preliminary data from our laboratory using a murine model of Klebsiella pneumoniae infection has shown that bacterial deposition in the lung results in the release of the T-cell derived ..
  32. Deverick John Anderson; Fiscal Year: 2015
    ..coli, MDR-Klebsiella pneumoniae, or methicillin-resistant Staphylococcus aureus (MRSA) in a community hospital to patients in a tertiary ..
  33. Laurence G Rahme; Fiscal Year: 2014
    ..aeruginosa in human infections and similarly form AT/P cells (i.e. Acinetobacter baumannii, Klebsiella pneumoniae, and Burkholderia species) will be tested in mono- and polymicrobial planktonic and biofilm settings...
  34. BACTERIAL UREASE IN THE CATHETERIZED URINARY TRACT
    HARRY MOBLEY; Fiscal Year: 1990
    ..from the catheterized urinary tract including Providencia stuartii Proteus mirabilis, Morganella morganii, Klebsiella pneumoniae, and Providencia rettgeri with respect to DNA homology, molecular weight, subunit composition, metal ion ..
  35. Jennifer Han; Fiscal Year: 2016
    ..In this proposal, the candidate will elucidate the epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in the LTACH setting...
  36. Peptide Derivatives to treat Urinary Tract Infections
    Laszlo Otvos; Fiscal Year: 2003
    ..and its designed analogs kill (-lactam-, tetracycline- and aminoglycoside-resistant Escherichia coli, Klebsiella pneumoniae, Salmonella typhimurium, and Haemophilus influenzae clinical isolates, among many others, in nanomolar or ..
  37. CHIROPTICAL SPECTROSCOPY OF METALLOPROTEINS
    Philip Stephens; Fiscal Year: 1990
    ..metalloproteins to be studied include the iron-sulfur (Fe-S) proteins: Desulfovibrio vulgaris hydrogenase, Klebsiella pneumoniae pyruvate-flavodoxin oxidoreductase, and Micrococcus aerogenes ferredoxin and the nickel-iron-sulfur enzyme:..
  38. Yohei Doi; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Klebsiella pneumoniae arbapenemase-producing K. pneumoniae (KPC-Kp) has emerged as an important nosocomial pathogen that is associated with high mortality and treatment failure rates...
  39. Eric G Pamer; Fiscal Year: 2016
    ..to resist colonization and infection by Vancomycin-resistant enterococcus (VRE) and carbapenem-resistant Klebsiella pneumoniae (KPC), two highly antibiotic resistant bacteria that are emerging causes of severe, frequently lethal ..
  40. Modulation of innate immunity in lung transplantation
    Sadis Matalon; Fiscal Year: 2005
    ..NO metabolism, and nitrotyrosine in the BAL of these patients; (3) Assess the extent of pathogen killing (Klebsiella pneumoniae, a gram negative bacterium and Staphylococcus aureus, a gram positive bacterium) by AMs isolated from the ..
  41. The Pseudomonas Aeruginosa Biofilm Dispersion Response
    David Davies; Fiscal Year: 2009
    ..aerugjnosa, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Streptococcus pyogenes, Staphylococcus aureus, and Candida albicans...
  42. MAST CELLS IN PULMONARY INFLAMMATION
    SOMAN ABRAHAM; Fiscal Year: 1999
    ..We have discovered that mast cells can interact with the pulmonary pathogen Klebsiella pneumoniae (Kp) through a mannose-binding protein (FimH) borne on the tips of surface organelles of these bacteria...
  43. Mast Cells and the Host Response in the Lung
    Paul Wolters; Fiscal Year: 2007
    ..knockout mice and determining the physiologic mechanism for survival following inoculation with Klebsiella pneumoniae. #2...
  44. INTERACTIONS OF THE SIGNAL TRANSDUCTION PROTEIN GLNK
    Alexander Ninfa; Fiscal Year: 2002
    ..GlnK regulates the activity of the NifA protein controlling nitrogenase synthesis when NifA and NifL from Klebsiella pneumoniae are introduced into E. coli along with a nif gene reporter. PII lacks the ability to regulate NifA...
  45. BODY TEMPERATURE AND REGULATING HOST DEFENSES
    Jeffrey Hasday; Fiscal Year: 2001
    ..to directly determine the following potential effects of core temperatures changes in mice infected with Klebsiella pneumoniae, a clinically relevant and virulent bacterial pathogen: (1) determine if febrile core temperatures enhance ..
  46. MICROBIAL ENZYMES INVOLVED IN NITROGEN METABOLISM
    LEONARD MORTENSON; Fiscal Year: 1980
    ..the in vitro efficiency of ATP utilization by the nitrogen-fixing system of Clostridium pasteurianum, Klebsiella pneumoniae and Azotobacter vinelandii. 2...
  47. Alcohol, Pulmonary Cytokines, and Host Defense
    Kyle Happel; Fiscal Year: 2009
    ..Specifically, alcohol's effect on IL-23 and IL-27 expression during pulmonary infection with Klebsiella pneumoniae will be studied...
  48. SALIVARY AND TRACHEOBRONCHIAL MUCINS IN DISEASE
    MOLAKALA REDDY; Fiscal Year: 1991
    ..125 I-MG1 to fresh isolates of Streptococcus pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterobacter species obtained from patients with documented respiratory infection...
  49. FUNCTIONS OF NIF ASSOCIATED PROTEINS
    Gary Roberts; Fiscal Year: 1990
    The molecular analysis of the nitrogen fixation (nif) system of Klebsiella pneumoniae is of relevance both for the basic scientific questions it addresses as well as for its implications for the understanding of the more agronomically ..
  50. SERINE PROTEINASES & LUNG HOST DEFENSE AGAINST BACTERIA
    Azzaq Belaaouaj; Fiscal Year: 2004
    ..We have observed that elastin peptides from NE-digested human lung elastin are bactericidal for Klebsiella pneumoniae in vitro...
  51. DEFENSE MECHANISMS OF THE LUNG
    Alan Pierce; Fiscal Year: 1980
    ..between defense mechanisms of the lung and the important human pathogens Streptococcus pneumoniae, Klebsiella pneumoniae, Straphylococcus aureus, and Pseudomonas aeruginosa...
  52. BIOMEDICAL RESEARCH PROGRAM
    JULIETTE BELL; Fiscal Year: 2000
    ..Characterization of ceftazidime resistance in Klebsiella pneumoniae (Raynor) 4. Theoretical studies on elasticity of microemulsions (Wu)...
  53. BINDING OF KLEBSIELLA FIMBRIAE TO RESPIRATORY TISSUE
    Steven Clegg; Fiscal Year: 2002
    The type 3 fimbrial adhesin (MrkD) of Klebsiella pneumoniae mediates binding of the bacteria to specific types of collagen...
  54. PATHOPHYSIOLOGICAL BIOCHEMICAL CHANGES OF THERMAL INJURY
    Fiemu Nwariaku; Fiscal Year: 2009
    ..decontamination of the digestive tract on postburn responses to subsequent sepsis (IT Streptococcus or Klebsiella pneumoniae) will be examined...
  55. Neutrophil-Microvascular Endothelial Cell Interactions in a Chronic Ethanol Model
    SONJA TANG; Fiscal Year: 2007
    ..In addition, we will investigate the effects of Klebsiella pneumoniae infection on neutrophil-endothelial cell interactions...
  56. INITIATION OF DNA REPLICATION IN E. COLI
    Andrew Wright; Fiscal Year: 1990
    ..looking at the effects of total shut-off of dnaA expression on initiation, and cloning and DNA sequence analysis of the dnaA gene from Klebsiella pneumoniae, a comparative study to see which regions of the dnaA gene have been conserved.
  57. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  59. 37th Annual Meeting of the Society for Leukocyte Biology
    Joshua Fierer; Fiscal Year: 2004
    ..We encourage students and other trainees to submit abstracts; the SLB gives awards for the best abstracts submitted by students. One of the main purposes of the meeting is to encourage young scientists. ..
  60. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010
    ..They will also test the use of exogenous leptin as an adjunctive therapeutic agent in the treatment of pneumococcal pneumonia. ..
  61. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
  62. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
  63. PSEUDOMONAS AERUGINOSA FLAGELLAR BIOGENESIS PATHWAY
    Reuben Ramphal; Fiscal Year: 2007
    ..abstract_text> ..

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