Escherichia coli CFT073

Summary

Alias: Escherichia coli str. CFT073, Escherichia coli strain CFT073

Top Publications

  1. pmc The broadly conserved regulator PhoP links pathogen virulence and membrane potential in Escherichia coli
    Christopher J Alteri
    Department of Microbiology and Immunology, University of Michigan Medical School, 5641 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Mol Microbiol 82:145-63. 2011
  2. ncbi Crystal structure of E. coli YhbY: a representative of a novel class of RNA binding proteins
    Gerard J Ostheimer
    Institute of Molecular Biology, 1229 University of Oregon, Eugene, OR 97403, USA
    Structure 10:1593-601. 2002
  3. pmc Characterization of a novel type IV pilus locus encoded on the large plasmid of locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli strains that are virulent for humans
    Potjanee Srimanote
    Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005, Australia
    Infect Immun 70:3094-100. 2002
  4. ncbi Solution structure of the R3H domain from human Smubp-2
    Edvards Liepinsh
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 17177, Stockholm, Sweden
    J Mol Biol 326:217-23. 2003
  5. pmc Pathogenicity island sequences of pyelonephritogenic Escherichia coli CFT073 are associated with virulent uropathogenic strains
    J S Kao
    Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 65:2812-20. 1997
  6. pmc Genomic analysis of a pathogenicity island in uropathogenic Escherichia coli CFT073: distribution of homologous sequences among isolates from patients with pyelonephritis, cystitis, and Catheter-associated bacteriuria and from fecal samples
    D M Guyer
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 66:4411-7. 1998
  7. ncbi Identification of DNA sequences from a second pathogenicity island of uropathogenic Escherichia coli CFT073: probes specific for uropathogenic populations
    D A Rasko
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Infect Dis 184:1041-9. 2001
  8. pmc Crystallization and X-ray diffraction analysis of salicylate synthase, a chorismate-utilizing enyme involved in siderophore biosynthesis
    James F Parsons
    Center for Advanced Research in Biotechnology, The University of Maryland Biotechnology Institute, Rockville, MD 20850, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:271-4. 2006
  9. ncbi Independent acquisition of site-specific recombination factors by asn tRNA gene-targeting genomic islands
    Uladzimir Antonenka
    Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Pettenkofer Str 9a, D 80336 Munich, Germany
    Int J Med Microbiol 296:341-52. 2006
  10. ncbi Structural characterization of enterobactin hydrolase IroE
    N A Larsen
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115 5702, USA
    Biochemistry 45:10184-90. 2006

Patents

  1. Plants with increased yield (lt)
  2. Process for the production of a fine chemical
  3. Proteins associated with abiotic stress response and homologs
  4. Altered Glyoxylate Shunt for Improved Production of Aspartate-Derived Amino Acids and Chemicals
  5. Yield increase in plants overexpressing the accdp genes
  6. Altered Glyoxylate Shunt for Improved Production of Aspartate-Derived Amino Acids and Chemicals
  7. Proteins associated with abiotic stress response and homologs
  8. Process for the control of production of fine chemicals
  9. Process for the production of fine chemicals
  10. Plants with increased yield (nue)

Detail Information

Publications151 found, 100 shown here

  1. pmc The broadly conserved regulator PhoP links pathogen virulence and membrane potential in Escherichia coli
    Christopher J Alteri
    Department of Microbiology and Immunology, University of Michigan Medical School, 5641 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Mol Microbiol 82:145-63. 2011
    ..These findings demonstrate a connection between PhoP, virulence and the energized state of the membrane...
  2. ncbi Crystal structure of E. coli YhbY: a representative of a novel class of RNA binding proteins
    Gerard J Ostheimer
    Institute of Molecular Biology, 1229 University of Oregon, Eugene, OR 97403, USA
    Structure 10:1593-601. 2002
    ..Taken together, the evidence suggests that members of UPF0044 constitute a previously unrecognized class of RNA binding domain...
  3. pmc Characterization of a novel type IV pilus locus encoded on the large plasmid of locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli strains that are virulent for humans
    Potjanee Srimanote
    Department of Molecular Biosciences, Adelaide University, Adelaide, South Australia 5005, Australia
    Infect Immun 70:3094-100. 2002
    ..Homologues of the pO113 pil locus were present in several other LEE-negative STEC strains but not in LEE-positive STEC strains belonging to serogroup O26, O111, or O157...
  4. ncbi Solution structure of the R3H domain from human Smubp-2
    Edvards Liepinsh
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 17177, Stockholm, Sweden
    J Mol Biol 326:217-23. 2003
    ..A strong correlation between conservation of hydrophobic amino acids and side-chain solvent protection indicates that the structure of the Smubp-2 R3H domain is representative of R3H domains in general...
  5. pmc Pathogenicity island sequences of pyelonephritogenic Escherichia coli CFT073 are associated with virulent uropathogenic strains
    J S Kao
    Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 65:2812-20. 1997
    ..When used as probes for DNA hybridization, these sequences were found significantly more often in strains associated with the clinical syndromes of cystitis (82%) and acute pyelonephritis (79%) than in fecal strains (19%; P < 0.001)...
  6. pmc Genomic analysis of a pathogenicity island in uropathogenic Escherichia coli CFT073: distribution of homologous sequences among isolates from patients with pyelonephritis, cystitis, and Catheter-associated bacteriuria and from fecal samples
    D M Guyer
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 66:4411-7. 1998
    ..001). From these regions, we have identified a putative iron transport system and genes other than hly and pap that may contribute to the virulent phenotype of uropathogenic E. coli strains...
  7. ncbi Identification of DNA sequences from a second pathogenicity island of uropathogenic Escherichia coli CFT073: probes specific for uropathogenic populations
    D A Rasko
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Infect Dis 184:1041-9. 2001
    ..These data suggest that groups of uropathogens have genetic differences that may be responsible for the different clinical outcomes...
  8. pmc Crystallization and X-ray diffraction analysis of salicylate synthase, a chorismate-utilizing enyme involved in siderophore biosynthesis
    James F Parsons
    Center for Advanced Research in Biotechnology, The University of Maryland Biotechnology Institute, Rockville, MD 20850, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:271-4. 2006
    ..Crystals of salicylate synthase from the uropathogen Escherichia coli CFT073 have been grown by vapour diffusion using polyethylene glycol as the precipitant...
  9. ncbi Independent acquisition of site-specific recombination factors by asn tRNA gene-targeting genomic islands
    Uladzimir Antonenka
    Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Pettenkofer Str 9a, D 80336 Munich, Germany
    Int J Med Microbiol 296:341-52. 2006
    ..the Ecoc54N island possibly encodes a polyketide synthase with an unknown function in the uropathogenic Escherichia coli CFT073 strain...
  10. ncbi Structural characterization of enterobactin hydrolase IroE
    N A Larsen
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115 5702, USA
    Biochemistry 45:10184-90. 2006
    ..Here, we report the crystal structure of IroE from uropathogenic Escherichia coli CFT073. The native structure and a complex with diisopropyl fluorophosphonate (DFP, a potent serine hydrolase ..
  11. pmc Regulation of P-fimbrial phase variation frequencies in Escherichia coli CFT073
    Nicola Holden
    Centre for Infectious Diseases, Royal Dick School of Veterinary Studies, Chancellor s Building, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, United Kingdom
    Infect Immun 75:3325-34. 2007
    ..coli K-12. Furthermore, phase transition frequencies for the two E. coli CFT073 pap clusters were shown to be different depending on the culture conditions, indicating that there is a hierarchy of expression depending on signal inputs...
  12. pmc Roles of serine accumulation and catabolism in the colonization of the murine urinary tract by Escherichia coli CFT073
    Andrew T Anfora
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, 1300 University Ave, Room 481 MSC, Madison, WI 53706, USA
    Infect Immun 75:5298-304. 2007
    A D-serine deaminase (DsdA) mutant of uropathogenic Escherichia coli strain CFT073 has a hypercolonization phenotype in a murine model of urinary tract infection (UTI) due to increased virulence gene expression by an unknown mechanism (B...
  13. doi Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins
    Christine Cirl
    Institut fur Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universitat Munchen, Trogerstrasse 30, D 81675 Munchen, Germany
    Nat Med 14:399-406. 2008
    ..Genes encoding TIR domain containing-proteins (Tcps) were identified in Escherichia coli CFT073 (TcpC) and Brucella melitensis (TcpB). We found that TcpC is common in the most virulent uropathogenic E...
  14. pmc Uropathogenic Escherichia coli CFT073 is adapted to acetatogenic growth but does not require acetate during murine urinary tract infection
    Andrew T Anfora
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, WI 53706, USA
    Infect Immun 76:5760-7. 2008
    In vivo accumulation of D-serine by Escherichia coli CFT073 leads to elevated expression of PAP fimbriae and hemolysin by an unknown mechanism...
  15. doi Anti-adhesion activity of two biosurfactants produced by Bacillus spp. prevents biofilm formation of human bacterial pathogens
    F Rivardo
    Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences DiSCAFF, Drug and Food Biotechnology Centre, University of Eastern Piedmont, Via Bovio 6, 28100 Novara, Italy
    Appl Microbiol Biotechnol 83:541-53. 2009
    ..In particular, Escherichia coli CFT073 and Staphylococcus aureus ATCC 29213 biofilm formation was decreased of 97% and 90%, respectively...
  16. pmc Characterization of two homologous disulfide bond systems involved in virulence factor biogenesis in uropathogenic Escherichia coli CFT073
    Makrina Totsika
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Bacteriol 191:3901-8. 2009
    ..In a mouse urinary tract infection model, the isogenic dsbAB deletion mutant of CFT073 was severely attenuated, while deletion of dsbLI or assT did not affect colonization...
  17. doi On the similar spatial arrangement of active site residues in PAPS-dependent and phenolic sulfate-utilizing sulfotransferases
    Takamasa Teramoto
    Laboratory of Structural Biology, Department of Systems Life Sciences, Graduate School, Faculty of Agriculture, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka 812 8581, Japan
    FEBS Lett 583:3091-4. 2009
    ..arrangement of the active site residues as well as the cognate substrates in mouse ST (mSULT1D1) and Escherichia coli CFT073 ASST, despite that their overall structures bear no discernible relationship...
  18. pmc Absence of ZnuABC-mediated zinc uptake affects virulence-associated phenotypes of uropathogenic Escherichia coli CFT073 under Zn(II)-depleted conditions
    Thusitha S Gunasekera
    Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
    FEMS Microbiol Lett 300:36-41. 2009
    In an effort to uncover the role of the high-affinity Zn(II) uptake system in uropathogenic Escherichia coli CFT073, we deleted the znuB gene, which encodes for the transmembrane component of the ZnuABC transporter system...
  19. doi Individual and co-operative roles of lactic acid and hydrogen peroxide in the killing activity of enteric strain Lactobacillus johnsonii NCC933 and vaginal strain Lactobacillus gasseri KS120.1 against enteric, uropathogenic and vaginosis-associated pathog
    Fabrice Atassi
    INSERM, UMR 756, Chatenay Malabry, France
    FEMS Microbiol Lett 304:29-38. 2010
    ..Salmonella enterica serovar Typhimurium SL1344, vaginal Gardnerella vaginalis DSM 4944 and urinary tract Escherichia coli CFT073 pathogens...
  20. pmc UpaH is a newly identified autotransporter protein that contributes to biofilm formation and bladder colonization by uropathogenic Escherichia coli CFT073
    Luke P Allsopp
    School of Chemistry and Molecular Biosciences, Building 76, University of Queensland, Brisbane QLD 4072, Australia
    Infect Immun 78:1659-69. 2010
    ..However, in competitive colonization experiments, CFT073 significantly outcompeted its upaH isogenic mutant strain in urine and the bladder...
  21. doi Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems
    Mark A Arbing
    Department of Biological Sciences, Columbia University, 702 Fairchild Center, MC2434, New York, NY 10027, USA
    Structure 18:996-1010. 2010
    ..Our crystal structures of Phd-Doc from bacteriophage P1, the HigA antitoxin from Escherichia coli CFT073, and YeeU of the YeeUWV systems from E...
  22. pmc Induction of a state of iron limitation in uropathogenic Escherichia coli CFT073 by cranberry-derived proanthocyanidins as revealed by microarray analysis
    Gabriela Hidalgo
    Dept of Chemical Engineering, McGill University, Montreal, Quebec H3A 2B2, Canada
    Appl Environ Microbiol 77:1532-5. 2011
    Transcriptional profiles of uropathogenic Escherichia coli CFT073 exposed to cranberry-derived proanthocyanidins (PACs) were determined. Our results indicate that bacteria grown on media supplemented with PACs were iron deprived...
  23. doi Synergistic effect of lipopeptide biosurfactant with antibiotics against Escherichia coli CFT073 biofilm
    Fabrizio Rivardo
    Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences DiSCAFF, Drug and Food Biotechnology Centre, University of Eastern Piedmont, Via Bovio 6, 28100 Novara, Italy
    Int J Antimicrob Agents 37:324-31. 2011
    ..coli CFT073 biofilm...
  24. pmc A unique arabinose 5-phosphate isomerase found within a genomic island associated with the uropathogenicity of Escherichia coli CFT073
    Joshua A Mosberg
    Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109 1065, USA
    J Bacteriol 193:2981-8. 2011
    Previous studies showed that deletion of genes c3405 to c3410 from PAI-metV, a genomic island from Escherichia coli CFT073, results in a strain that fails to compete with wild-type CFT073 after a transurethral cochallenge in mice and is ..
  25. pmc Inhibition of Escherichia coli CFT073 fliC expression and motility by cranberry materials
    Gabriela Hidalgo
    Department of Chemical Engineering, McGill University, 3610 University Street, Montreal, Quebec H3A 2B2, Canada
    Appl Environ Microbiol 77:6852-7. 2011
    ..This is the first report to show that cranberry compounds inhibit UPEC motility via downregulation of the fliC gene. Further studies are required to establish whether these inhibitors play a role in vivo...
  26. pmc Molecular characterization of UpaB and UpaC, two new autotransporter proteins of uropathogenic Escherichia coli CFT073
    Luke P Allsopp
    Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia
    Infect Immun 80:321-32. 2012
    ..This attenuated phenotype was also observed in single-challenge experiments, where deletion of the upaB gene in CFT073 significantly reduced early colonization of the bladder...
  27. pmc Chemoreceptors of Escherichia coli CFT073 play redundant roles in chemotaxis toward urine
    Erica L Raterman
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 8:e54133. 2013
    ..coli strain CFT073 in this niche...
  28. pmc Pleiotropic roles of uvrY on biofilm formation, motility and virulence in uropathogenic Escherichia coli CFT073
    Arindam Mitra
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 8:e55492. 2013
    ..Taken together, our findings unravel a possible mechanism in which uvrY facilitates biofilm formation, persistence and virulence of uropathogenic E. coli...
  29. pmc RpoS contributes to phagocyte oxidase-mediated stress resistance during urinary tract infection by Escherichia coli CFT073
    Andrew J Hryckowian
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin, USA
    MBio 4:e00023-13. 2013
    ..Though σ(S) affects the pathogenesis of other bacterial species, this is the first work that directly implicates σ(S) as important for UPEC pathogenesis...
  30. pmc The multifunctional protein YdiV represses P fimbria-mediated adherence in uropathogenic Escherichia coli
    Rachel R Spurbeck
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA
    J Bacteriol 195:3156-64. 2013
    ..deletion of ydiV dysregulates coordinate control of motility and adherence by increasing adherence of Escherichia coli CFT073 to a bladder epithelial cell line by specifically increasing production of P fimbriae...
  31. doi Inhibition of bacterial motility and spreading via release of cranberry derived materials from silicone substrates
    Michelle Chan
    Department of Chemical Engineering, McGill University, 3610 University Street, Montreal, Quebec H3A 2B2, Canada
    Colloids Surf B Biointerfaces 110:275-80. 2013
    ..remain bioactive as they downregulate the expression of the flagellin gene of two key uropathogens - Escherichia coli CFT073 and Proteus mirabilis HI4320...
  32. pmc Genetic analysis of the role of yfiR in the ability of Escherichia coli CFT073 to control cellular cyclic dimeric GMP levels and to persist in the urinary tract
    Erica L Raterman
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin, USA
    Infect Immun 81:3089-98. 2013
    ..coli in the urinary tract and implicate the c-di-GMP regulatory system as an important factor in the persistence of uropathogenic E. coli in vivo. ..
  33. doi Activity of fosfomycin alone or combined with cefoxitin in vitro and in vivo in a murine model of urinary tract infection due to Escherichia coli harbouring CTX-M-15-type extended-spectrum β-lactamase
    Agnes Lefort
    EA3964, Faculte de Medecine Xavier Bichat, Universite Paris Diderot, Paris, France Electronic address
    Int J Antimicrob Agents 43:366-9. 2014
    ..cefoxitin was investigated in vitro and in a murine model of urinary tract infection due to susceptible Escherichia coli CFT073-RR and its transconjugant CFT073-RR Tc (pblaCTX-M-15) harbouring a plasmid carrying the blaCTX-M-15 gene...
  34. doi Structural and mechanistic insights into the PAPS-independent sulfotransfer catalyzed by bacterial aryl sulfotransferase and the role of the DsbL/Dsbl system in its folding
    Goran Malojcic
    Institute of Molecular Biology and Biophysics, ETH Zurich, CH 8093 Zurich, Switzerland
    Biochemistry 53:1870-7. 2014
    ..Here, the crystal structures of Escherichia coli CFT073 ASST trapped in its presulfurylation state with model donor substrates bound in the active site are ..
  35. pmc Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism of L-gulonate and L-idonate
    Daniel J Wichelecki
    Departments of Biochemistry and Chemistry and Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, United States
    Biochemistry 53:5692-9. 2014
    ..in Chromohalobacter salexigens DSM3043 as well as cryptic pathways for L-gulonate catabolism in Escherichia coli CFT073 and L-idonate catabolism in Salmonella enterica subsp. enterica serovar Enteritidis str. P125109...
  36. doi A novel glucose 6-phosphate isomerase from Listeria monocytogenes
    David L Cech
    Department of Medicinal Chemistry, University of Michigan, 428 Church Street, Ann Arbor, MI, 48109 1065, USA
    Protein J 33:447-56. 2014
    ..sugar isomerase domain API, Q723E8, with significant similarity to c3406, the only one of four APIs from Escherichia coli CFT073 that lacks a cystathionine-β-synthase domain. However, L...
  37. pmc Alkaloids modulate motility, biofilm formation and antibiotic susceptibility of uropathogenic Escherichia coli
    Devendra H Dusane
    Department of Chemical Engineering, McGill University, Montreal, Quebec, Canada
    PLoS ONE 9:e112093. 2014
    ..in black pepper) and reserpine (found in Indian snakeroot), on the ability of the uropathogenic bacterium Escherichia coli CFT073 to colonize abiotic surfaces. Sub-inhibitory concentrations of both compounds (0...
  38. pmc Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli
    Dounia Houamel
    National Institute of Health and Medical Research INSERM U1149, Research Centre on inflammation, Paris, France Paris Diderot University, Sorbonne Paris Cité, Paris, France Laboratory of Excellence, Gr Ex, Paris, France
    J Am Soc Nephrol 27:835-46. 2016
    ..UTI was induced in wild-type (WT) and hepcidin-knockout (Hepc-/-) mice using the uropathogenic Escherichia coli CFT073 strain...
  39. pmc dsdA Does Not Affect Colonization of the Murine Urinary Tract by Escherichia coli CFT073
    Andrew J Hryckowian
    Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 10:e0138121. 2015
    ..These findings indicate that D-serine catabolism, though it may play role(s) during urinary tract infection, does not affect the ability of uropathogenic E. coli to colonize the murine urinary tract. ..
  40. doi GIPSy: Genomic island prediction software
    Siomar C Soares
    Department of Immunology, Microbiology and Parasitology, Federal University of Triangulo Mineiro, Uberaba, Minas Gerais, Brazil Department of General Biology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil Electronic address
    J Biotechnol 232:2-11. 2016
    ..Briefly, GIPSy correctly predicted the following previously described GEIs: 13 PAIs larger than 30kb in Escherichia coli CFT073; 1 MI for Burkholderia pseudomallei K96243, which seems to be a miscellaneous island; 1 RI of ..
  41. pmc Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
    Shweta Pasi
    From the Molecular Science Laboratory, National Institute of Immunology, New Delhi 110067, India and Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India
    J Biol Chem 291:12358-69. 2016
    ..One such pathogen, Escherichia coli CFT073, utilizes an immunomodulatory protein, TcpC, to combat the host's innate immune defense...
  42. pmc Uropathogenic Escherichia coli Metabolite-Dependent Quiescence and Persistence May Explain Antibiotic Tolerance during Urinary Tract Infection
    Mary P Leatham-Jensen
    Department of Cell and Molecular Biology, University of Rhode Island, Kingston, Rhode Island, USA
    mSphere 1:. 2016
    ....
  43. pmc Coupling of radiofrequency with magnetic nanoparticles treatment as an alternative physical antibacterial strategy against multiple drug resistant bacteria
    Akhilesh K Chaurasia
    Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Korea
    Sci Rep 6:33662. 2016
    ..In this approach, multiple drug resistant Staphylococcus aureus USA300 and uropathogenic Escherichia coli CFT073 are trapped to the positively charged magnetic core-shell nanoparticles (MCSNPs) by electrostatic ..
  44. ncbi Gene fusion during the evolution of the tryptophan operon in enterobacteriaceae
    G F Miozzari
    Nature 277:486-9. 1979
  45. ncbi Nucleotide sequence of the intercistronic region preceding the gene for RNA polymerase subunit alpha in Escherichia coli
    L E Post
    J Biol Chem 254:10604-6. 1979
    ..This short distance supports the idea that some post-transcriptional regulation determines the differential synthesis of alpha and ribosomal proteins...
  46. ncbi Cloning, sequencing, and overexpression of a [2Fe-2S] ferredoxin gene from Escherichia coli
    D T Ta
    Department of Physiology and Biophysics, University of California, Irvine 92717
    J Biol Chem 267:11120-5. 1992
    ..The overexpressed ferredoxin exhibits absorption, circular dichroism, and electron paramagnetic resonance spectra closely resembling those of the animal ferredoxins and P. putida ferredoxin...
  47. ncbi Characterization of the hemolysin transporter, HlyB, using an epitope insertion
    P Juranka
    Ontario Cancer Institute, University of Toronto, Canada
    J Biol Chem 267:3764-70. 1992
    ..This has allowed us to use immunological methods to identify and localize various molecular forms of the HlyB protein present in vivo...
  48. pmc Isolation, cloning, mapping, and nucleotide sequencing of the gene encoding flavodoxin in Escherichia coli
    C Osborne
    Biophysics Research Division, University of Michigan, Ann Arbor 48109
    J Bacteriol 173:1729-37. 1991
    ..The fldA gene maps at 15.9 min on the E. coli chromosome and is transcribed in a counterclockwise direction...
  49. ncbi A molecular analysis of the 53.3 minute region of the Escherichia coli linkage map
    S C Andrews
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, UK
    J Gen Microbiol 137:361-7. 1991
    ..The translation product of orf3 (205 amino acid codons) resembled the iron-sulphur protein component (DMS B subunit) of the anaerobic dimethylsulphoxide reductase complex of E. coli...
  50. pmc Cloning, expression, and nucleotide sequence of the Escherichia coli K-12 ackA gene
    A Matsuyama
    Research and Development Division, Kikkoman Corporation, Chiba ken, Japan
    J Bacteriol 171:577-80. 1989
    ..It was deduced that the ackA gene coded for a protein of 400 amino acids with an Mr of 43,297. The ackA gene was found to be located about 15 kilobases upstream of the purF-folC-hisT region of the chromosome...
  51. ncbi Periplasmic binding protein structure and function. Refined X-ray structures of the leucine/isoleucine/valine-binding protein and its complex with leucine
    J S Sack
    Howard Hughes Medical Institute, Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030
    J Mol Biol 206:171-91. 1989
    ..abstract truncated at 400 words)..
  52. pmc Purification and characterization of the deoR repressor of Escherichia coli
    L Mortensen
    Institute of Biological Chemistry B, University of Copenhagen, Denmark
    EMBO J 8:325-31. 1989
    ....
  53. ncbi Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 A resolution
    I T Weber
    Center for Chemical Physics, National Bureau of Standards, Gaithersburg, MD 20899
    J Mol Biol 198:311-26. 1987
    ..Each cyclic AMP molecule is in an anti conformation and has ionic and hydrogen bond interactions with both subunits...
  54. ncbi Transcriptional organization of the dnaN and recF genes of Escherichia coli K-12
    M E Armengod
    Instituto de Investigaciones Citologicas, Obra Social de la Caja de Ahorros de Valencia, Spain
    J Biol Chem 263:12109-14. 1988
    ..The uncoupling of transcription and translation of the dnaN gene (when translation is interrupted by premature nonsense codons or by other mechanisms) probably results in transcription termination at termination signals in dnaN...
  55. ncbi Nucleotide sequence of the dmsABC operon encoding the anaerobic dimethylsulphoxide reductase of Escherichia coli
    P T Bilous
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Mol Microbiol 2:785-95. 1988
    ..The DMS C polypeptide is composed of eight segments of hydrophobic amino acids of appropriate length to cross the cytoplasmic membrane, suggesting that this subunit functions to anchor the enzyme to the membrane...
  56. pmc Altered molecular form of acyl carrier protein associated with beta-ketoacyl-acyl carrier protein synthase II (fabF) mutants
    S Jackowski
    J Bacteriol 169:1469-73. 1987
    ..Therefore, F-ACP appears to be a modification of ACP that is detected when beta-ketoacyl-ACP synthase II activity is impaired...
  57. pmc Role of translation and attenuation in the control of pyrBI operon expression in Escherichia coli K-12
    K L Roland
    J Bacteriol 163:991-9. 1985
    ..This mutation greatly reduced operon expression and regulation as predicted by the attenuation control model...
  58. pmc Primary structure of the Escherichia coli ribonucleoside diphosphate reductase operon
    J Carlson
    Proc Natl Acad Sci U S A 81:4294-7. 1984
    ..The sequences reveal not only the primary structures for both subunits, but also some interesting aspects of potential regulatory sites...
  59. pmc Nucleotide sequence of the rpoA-rplQ DNA of Escherichia coli: a second regulatory binding site for protein S4?
    D W Meek
    Nucleic Acids Res 12:5813-21. 1984
    ..The rpoA-rplQ intercistronic region shows strong primary, and potential secondary structural homologies with the S4-binding sites on 16S rRNA and S13 mRNA. We suggest that S4 represses L17 translation directly...
  60. pmc Initiator proteins for the assembly of the 50S subunit from Escherichia coli ribosomes
    V Nowotny
    Proc Natl Acad Sci U S A 79:7238-42. 1982
    ....
  61. ncbi A model for transcription termination suggested by studies on the trp attenuator in vitro using base analogs
    P J Farnham
    Cell 20:739-48. 1980
  62. ncbi The primary structure of elongation factor G from Escherichia coli. A complete amino acid sequence
    - Ovchinnikov YuA
    FEBS Lett 139:130-5. 1982
  63. ncbi Formation of SRP-like particle induces a conformational change in E. coli 4.5S RNA
    G Lentzen
    Institut fur Molekularbiologie, Universitat Witten Herdecke, Germany
    FEBS Lett 348:233-8. 1994
    ..From equilibrium titrations with fluorescent 4.5S RNA, a dissociation constant of 0.15 microns is obtained for the RNA.protein complex. The formation of the complex is not affected by GTP binding to or hydrolysis by P48...
  64. ncbi Evidence for effect of random genetic drift on G+C content after lateral transfer of fucose pathway genes to Escherichia coli K-12
    K Aoyama
    Department of Microbiology, University of Sydney, N S W, Australia
    Mol Biol Evol 11:829-38. 1994
    ..coli took place approximately 45 million years ago. This is the first report we are aware of demonstrating the expected adjustment of P3 after lateral transfer between species with different G+C content DNA...
  65. pmc The cmk gene encoding cytidine monophosphate kinase is located in the rpsA operon and is required for normal replication rate in Escherichia coli
    J Fricke
    Department of Molecular Cell Biology, University of Copenhagen, Denmark
    J Bacteriol 177:517-23. 1995
    ..In addition to the physiological studies, the region upstream of cmk was sequenced, and 120 codons with strong homology to an uncharacterized protein of the speB operon were identified...
  66. ncbi Purification of a MalE-SoxS fusion protein and identification of the control sites of Escherichia coli superoxide-inducible genes
    W P Fawcett
    Department of Biological Sciences, University of Maryland, Catonsville 21228
    Mol Microbiol 14:669-79. 1994
    ..Moreover, MalE-SoxS protected from DNase I attack 22-27 bp segments immediately adjacent to or overlapping the -35 hexamers of the zwf, sodA, nfo, micF, and fumC promoters. The protected regions revealed a consensus 'soxbox' sequence...
  67. pmc Nucleotide sequence, mutational analysis, transcriptional start site, and product analysis of nov, the gene which affects Escherichia coli K-12 resistance to the gyrase inhibitor novobiocin
    R Ivanisevic
    Institute of Molecular Genetics and Genetic Engineering, Belgrade, Yugoslavia
    J Bacteriol 177:1766-71. 1995
    ..coli K-12 map is att phi 80-open reading frame of unknown function-kch (potassium channel protein)-nov-opp. Finally, the possible identity of the nov gene with cls, the gene that codes for cardiolipin synthase, is also discussed...
  68. ncbi Adhesin regulatory genes within large, unstable DNA regions of pathogenic Escherichia coli: cross-talk between different adhesin gene clusters
    J Morschhäuser
    Institut für Molekulare Infektionsbiologie, Wurzburg, Germany
    Mol Microbiol 11:555-66. 1994
    ..The results demonstrate that cross-regulation of two unlinked virulence gene clusters together with the co-ordinate loss of large DNA regions significantly influences the virulence of an extraintestinal E. coli wild-type isolate...
  69. ncbi Analysis of genes coding for the major and minor fimbrial subunits of the Prs-like fimbriae F165(1) of porcine septicemic Escherichia coli strain 4787
    S N Maiti
    Group de recherche sur les maladies infectieuses du porc GREMIP, Faculty of Veterinary Medicine, University of Montreal, Saint Hyacinthe, Quebec, Canada
    Microb Pathog 16:15-25. 1994
    ..Our results indicated that the f165(1) is a mosaic operon consisting of sequences related to both the pap operon and the prs operon...
  70. pmc Interactions between the Escherichia coli MelR transcription activator protein and operator sequences at the melAB promoter
    J Williams
    School of Biochemistry, University of Birmingham, U K
    Biochem J 300:757-63. 1994
    ..The other mutants contain substitutions throughout the central part of MelR and appear to alter the conformation of MelR, such that activity is triggered at lower melibiose concentrations and by arabinose...
  71. pmc SpoU protein of Escherichia coli belongs to a new family of putative rRNA methylases
    E V Koonin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894
    Nucleic Acids Res 21:5519. 1993
  72. ncbi Overproduction, purification and characterization of the Escherichia coli ferritin
    A J Hudson
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, England
    Eur J Biochem 218:985-95. 1993
    ..E. coli is thus an organism containing both a ferritin and a bacterioferritin and the relative roles of the two iron-storage proteins are discussed in this study...
  73. pmc Regulation of the Escherichia coli hfq gene encoding the host factor for phage Q beta
    M Kajitani
    Department of Molecular Genetics, National Institute of Genetics, Shizuoka, Japan
    J Bacteriol 176:531-4. 1994
    ..The intracellular level of HF-I is about 30,000 to 60,000 molecules per cell, the majority being associated with ribosomes as one of the salt wash proteins. Taken together, we suggest that HF-I is one of the growth-related proteins...
  74. ncbi Overproduction, purification and characterization of the bacterioferritin of Escherichia coli and a C-terminally extended variant
    S C Andrews
    Krebs Institute of Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, England
    Eur J Biochem 213:329-38. 1993
    ..A combination of Mössbauer spectroscopy and electron diffraction showed that the BFR loaded with iron in vitro has a ferrihydrite-like iron core, whereas the in-vivo loaded protein has an amorphous core...
  75. ncbi Glutaredoxin-3 from Escherichia coli. Amino acid sequence, 1H AND 15N NMR assignments, and structural analysis
    F Aslund
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Biol Chem 271:6736-45. 1996
    ..Thus, despite an identical active site disulfide motif and a similar secondary structure and tertiary fold, Grx3 and Grx1 display large functional differences in in vitro protein disulfide oxido-reduction reactions...
  76. ncbi An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q
    C R Sage
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448, USA
    Biochemistry 35:16270-81. 1996
    ....
  77. pmc DNA binding and DNA bending by the MelR transcription activator protein from Escherichia coli
    S J Bourgerie
    School of Biochemistry, The University of Birmingham, PO Box 363, Birmingham B15 2TT, UK
    Nucleic Acids Res 25:1685-93. 1997
    ..Bound full-length MelR, but not MelR173, can oligomerise to form larger complexes that are likely to be involved in transcription activation...
  78. pmc Host regulation of lysogenic decision in bacteriophage lambda: transmembrane modulation of FtsH (HflB), the cII degrading protease, by HflKC (HflA)
    A Kihara
    Department of Cell Biology, Institute for Virus Research, Kyoto University, Kyoto 606 01, Japan
    Proc Natl Acad Sci U S A 94:5544-9. 1997
    ..This study necessitates a revision of the prevailing view about the host control over lambda lysogenic decision...
  79. pmc Crystal structure of the site-specific recombinase, XerD
    H S Subramanya
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    EMBO J 16:5178-87. 1997
    ....
  80. ncbi Assembly of iron-sulfur clusters. Identification of an iscSUA-hscBA-fdx gene cluster from Azotobacter vinelandii
    L Zheng
    Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061 0346, USA
    J Biol Chem 273:13264-72. 1998
    ..These results show that the cysE-like gene located upstream from iscS is not essential for cell growth and that the cysE-like gene and the iscSUA-hscBA-fdx genes are contained within separate transcription units...
  81. pmc Sequence analysis of the GntII (subsidiary) system for gluconate metabolism reveals a novel pathway for L-idonic acid catabolism in Escherichia coli
    C Bausch
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210, USA
    J Bacteriol 180:3704-10. 1998
    ..E. coli K-12 strains are able to utilize L-idonate as the sole carbon and energy source, and as predicted, the ability of idnD, idnK, idnR, and edd mutants to grow on L-idonate is altered...
  82. ncbi GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition
    Y Xu
    Research School of Chemistry, Australian National University, GPO 414, Canberra, ACT, 2601, Australia
    J Mol Biol 282:149-65. 1998
    ..This sequence is more highly conserved than the functional T-loop, suggesting that ATP has an important role in PII-like proteins...
  83. ncbi FtsZ ring clusters in min and partition mutants: role of both the Min system and the nucleoid in regulating FtsZ ring localization
    X C Yu
    Department of Microbiology and Molecular Genetics, University of Texas Medical School, 6431 Fannin, Houston, TX 77030, USA
    Mol Microbiol 32:315-26. 1999
    ..A model is proposed in which both the inhibitory effect of the nucleoid and the regulation by MinCDE ensure that cells divide precisely at the midpoint...
  84. pmc Assessment of the allosteric mechanism of aspartate transcarbamoylase based on the crystalline structure of the unregulated catalytic subunit
    P T Beernink
    Department of Molecular and Cell Biology and Virus Laboratory, University of California, Berkeley, CA 94720 3206, USA
    Proc Natl Acad Sci U S A 96:5388-93. 1999
    ..Large differences in structure between the active C trimer and the holoenzyme:bisubstrate-analog complex call into question the view that this complex represents the activated R state of ATCase...
  85. ncbi Novel roles for classical factors at the interface between translation termination and initiation
    R Karimi
    Department of Cell and Molecular Biology, Biomedical Center, Uppsala, Sweden
    Mol Cell 3:601-9. 1999
    ..We show that this step requires initiation factor IF3, whose role was previously thought to be restricted to promoting specific 30S initiation complex formation from free 30S subunits...
  86. ncbi Membrane cyclopropane fatty acid content is a major factor in acid resistance of Escherichia coli
    Y Y Chang
    Department of Microbiology, University of Illinois, Urbana 61801, USA
    Mol Microbiol 33:249-59. 1999
    ..Much, but not all, of this variability can be explained by the partially or totally defective RpoS alleles carried by many strains...
  87. ncbi Genetic organization of the O7-specific lipopolysaccharide biosynthesis cluster of Escherichia coli VW187 (O7:K1)
    C L Marolda
    Department of Microbiology and Immunology, University of Western Ontario, London, Canada
    Microbiology 145:2485-95. 1999
    ..The O antigen chain length regulator gene wzz was also identified in the vicinity of the O7 polysaccharide cluster. O7-specific DNA primers were designed and tested for serotyping of O7 E. coli strains...
  88. ncbi Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family
    W Jeong
    National Creative Research Center for Antioxidant Proteins, Department of Biochemistry, Paichai University, Taejon 302 735, Korea
    J Biol Chem 275:2924-30. 2000
    ..Taken together, these data suggest that BCP is a new member of thioredoxin-dependent TSA/AhpC family, acting as a general hydroperoxide peroxidase...
  89. ncbi RpoS-dependent promoters require guanosine tetraphosphate for induction even in the presence of high levels of sigma(s)
    K Kvint
    Department of Cell and Molecular Biology Microbiology, Goteborg University, Box 462, 405 30 Goteborg, Sweden
    J Biol Chem 275:14795-8. 2000
    ....
  90. ncbi Dimerization of signalling modules of the EvgAS and BvgAS phosphorelay systems
    A L Perraud
    Lehrstuhl fur Mikrobiologie, Biozentrum, Universitat Wurzburg, Germany
    Biochim Biophys Acta 1478:341-54. 2000
    ..In agreement with these data, surface plasmon resonance studies revealed a 2:1 stoichiometry in the interaction of EvgA with the immobilized EvgS HPt domain and an affinity constant of 1. 24x10(6) M(-1)...
  91. ncbi Conserved cytoplasmic motifs that distinguish sub-groups of the polyprenol phosphate:N-acetylhexosamine-1-phosphate transferase family
    M S Anderson
    Department of Chemistry, State University of New York College of Environmental Science and Forestry, Syracuse, NY 13210, USA
    FEMS Microbiol Lett 191:169-75. 2000
    ..Four diverse loops are apparent, for MraY, WecA, WbcO and RgpG, that uniquely characterize these sub-groups of the transferase family, and a correlation is evident with the known or implied UDP-sugar specificity...
  92. ncbi Interaction of ribosome recycling factor and elongation factor EF-G with E. coli ribosomes studied by the surface plasmon resonance technique
    T Ishino
    RRF Research Inc, Kannondai, Tsukuba, Ibaraki, 305 0856, Japan
    Genes Cells 5:953-63. 2000
    ..Crystal structures of RRF molecules have been solved recently and shown to mimic a transfer RNA (tRNA) shape, which prompted us to examine whether RRF binds to the ribosome as tRNA does...
  93. ncbi Involvement of RNase G in in vivo mRNA metabolism in Escherichia coli
    G Umitsuki
    Department of Bioengineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    Genes Cells 6:403-10. 2001
    ..In rng mutant cells, a precursor form of 16S rRNA, 16.3S rRNA, is accumulated. Here we report a role of RNase G in the in vivo mRNA metabolism...
  94. ncbi Radical mechanisms of enzymatic catalysis
    P A Frey
    Department of Biochemistry, University of Wisconsin Madison, 1710 University Avenue, Madison, Wisconsin 53705, USA
    Annu Rev Biochem 70:121-48. 2001
    ..Three examples are described of suicide inactivation through the formation of exceptionally stable free radicals at enzymatic active sites...
  95. pmc The fixA and fixB genes are necessary for anaerobic carnitine reduction in Escherichia coli
    Angelique Walt
    Institute of Biological Chemistry and School of Molecular Biosciences, Washington State University, Pullman 99164 6340, USA
    J Bacteriol 184:4044-7. 2002
    ..We have constructed E. coli fixA and fixB mutants and find that they are unable to reduce carnitine to gamma-butyrobetaine under anaerobic conditions...
  96. pmc Role of ppGpp in rpoS stationary-phase regulation in Escherichia coli
    Matthew Hirsch
    Department of Microbiology, Immunology and Cell Biology, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
    J Bacteriol 184:5077-87. 2002
    ..The effect of RBS-proximal sequence was independent of all known trans-acting factors, including ppGpp...
  97. pmc A single nucleotide exchange in the wzy gene is responsible for the semirough O6 lipopolysaccharide phenotype and serum sensitivity of Escherichia coli strain Nissle 1917
    Lubomir Grozdanov
    Institut für Molekulare Infektionsbiologie, Bayerische Julius Maximilians Universität Würzburg, Rontgenring 11, D 97070 Wurzburg, Germany
    J Bacteriol 184:5912-25. 2002
    ..coli strain Nissle 1917 increased its ability to withstand antibacterial defense mechanisms of blood serum. These results underline the importance of LPS for serum resistance or sensitivity of E. coli...
  98. pmc Analysis of genome plasticity in pathogenic and commensal Escherichia coli isolates by use of DNA arrays
    Ulrich Dobrindt
    Institut für Molekulare Infektionsbiologie der Universität Würzburg, 97070 Wurzburg, Germany
    J Bacteriol 185:1831-40. 2003
    ..coli strains and underline the fact that both the acquisition and deletion of DNA elements are important processes involved in the evolution of prokaryotes...
  99. ncbi RNase G of Escherichia coli exhibits only limited functional overlap with its essential homologue, RNase E
    Maria C Ow
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Mol Microbiol 49:607-22. 2003
    ..Thus, the failure of RNase G to complement rne mutations, even when overproduced at high levels, apparently results from its inability to substitute for RNase E in the maturation of tRNAs...
  100. pmc Involvement of enterobactin synthesis pathway in production of microcin H47
    María F Azpiroz
    Sección de Fisiología y Genética Bacterianas, Facultad de Ciencias, Montevideo 11 400, Uruguay
    Antimicrob Agents Chemother 48:1235-41. 2004
    ..The relationship found between MccH47 and catecholate siderophore production is discussed, and a model outlining MccH47 synthesis is proposed...
  101. ncbi Characterization of the Escherichia coli O59 and O155 O-antigen gene clusters: the atypical wzx genes are evolutionary related
    Hongjie Guo
    TEDA School of Biological Sciences and Biotechnology, Nankai University, Tianjin 300457, PR China
    FEMS Microbiol Lett 248:153-61. 2005
    ..Genes specific for E. coli O59 and O155, respectively, were also identified...

Research Grants15

  1. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  2. Postsynthetic Modifications of Bacterial Membrane Lipids
    John Cronan; Fiscal Year: 2006
    ..These processes will be studied by a combination of biochemical, genetic, and molecular biological approaches including tests of pathogenesis in a mouse model system ..
  3. Chaperone Function in Iron-Sulfur Protein Folding
    LARRY VICKERY; Fiscal Year: 2008
    ..abstract_text> ..
  4. Novel Approaches for the Control of Microbial Pathogens
    JOSEPH F LUTKENHAUS; Fiscal Year: 2010
    ..Finally, the new program has been based on our track record in which eleven investigators supported by the previous COBRE have secured a total of 16 extramural grants. Eight of the eleven have secured 12 NIH grants. ..
  5. ATP-DEPENDENT PROTEIN KINASES IN GRAM-POSITIVE BACTERIA
    Milton Saier; Fiscal Year: 2004
    ..abstract_text> ..
  6. Biochemistry of Phenazine Production in Pseudomonas aeruginosa
    James Parsons; Fiscal Year: 2009
    ..New strategies that complement existing antimicrobial therapies clearly need to be developed to more effectively combat P. aeruginosa infections. ..
  7. Enzyme Repair of Excoyclic Adducts
    Bo Hang; Fiscal Year: 2005
    ..abstract_text> ..
  8. ENZYME CATALYSIS OF ELECTRON AND GROUP TRANSFER
    PERRY FREY; Fiscal Year: 2006
    ..The contributions of beta- amino acids produced by lysine 2,3-aminomutase and arginine 2,3-aminomutase to the functions of antibiotics are not known. The beta-aminoacids may become significant in drug development. ..
  9. REGULATION BY THE ESCHERICHIA COLI SMALL RNA, DSRA
    DARREN SLEDJESKI; Fiscal Year: 2002
    ..3) To compare the effect of DsrA and H-NS on DNA structure in vivo. In vivo footprinting of multicopy plasmid genes regulated by H-NS/DsrA will be used to compare the effects of hns-mutations and overexpression of DsrA on DNA structure. ..
  10. Tools for Membrane Protein Structure Determination
    Vinzenz Unger; Fiscal Year: 2004
    ..This approach may make a large number of membrane proteins amenable to 2D-crystallization and structure determination. ..
  11. MECHANISMS OF ENZYMATIC REACTIONS
    PERRY FREY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  12. Role of G protein Coupling in Fe(ll)-Uptake in Bacteria
    Vinzenz Unger; Fiscal Year: 2006
    ..The fourth aim is to generate crystals of FeoB embedded in a lipid bilayer. Ultimately, this will allow visualization of FeoB, and reveal whether its structure is related to other G protein-coupled membrane proteins. ..
  13. Structure and Function of Copper Transporters
    Vinzenz Unger; Fiscal Year: 2009
    ..Using the substituted cysteine accessibility method and alanine scanning mutagenesis, we will test this hypothesis by determining how the different transmembrane helices contribute to such a copper uptake. ..

Patents21

  1. Plants with increased yield (lt)
    Patent Number: WO2010034672-A1; Date:2010-04-01
  2. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27
  3. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  4. Altered Glyoxylate Shunt for Improved Production of Aspartate-Derived Amino Acids and Chemicals
    Patent Number: JP2008543330-A; Date:2008-12-04
  5. Yield increase in plants overexpressing the accdp genes
    Patent Number: WO2007011625-A2; Date:2007-01-25
  6. Altered Glyoxylate Shunt for Improved Production of Aspartate-Derived Amino Acids and Chemicals
    Patent Number: JP2012187118-A; Date:2012-10-04
  7. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  8. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  9. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  10. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  11. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  12. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  13. Plants with increased yield by increasing or generating one or more activities in a plant or a part thereof
    Patent Number: WO2010020654-A2; Date:2010-02-25
  14. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  15. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  16. Improved strain for butanol production
    Patent Number: WO2009086075-A1; Date:2009-07-09
  17. Lipid metabolism proteins, combinations of lipid metabolism proteins and uses thereof
    Patent Number: WO2009077406-A1; Date:2009-06-25
  18. Plants with increased yield and/or increased tolerance to environmental stress (iy-bm)
    Patent Number: WO2009077611-A2; Date:2009-06-25
  19. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  20. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  21. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance to plant disease
    Patent Number: WO2009027539-A1; Date:2009-03-05