Genomes and Genes
Alias: Escherichia coli retron Ec86, Escherichia coli retron Ec79, Escherichia coli retron Ec67, Escherichia coli retron Ec107, "Bacterium coli commune" Escherich 1885, Escherichia coli (Migula 1895) Castellani and Chalmers 1919, Bacterium coli commune, Bacterium coli, Bacillus coli, "Bacterium coli" (Migula 1895) Lehmann and Neumann 1896, "Bacillus coli" Migula 1895, Escherchia coli, Eschericia coli, Enterococcus coli, bacterium 10a, bacterium E3
Publications2785 found, 100 shown here
- Analysis of the EHEC hly operon and its location in the physical map of the large plasmid of enterohaemorrhagic Escherichia coli O157:h7H Schmidt
Institut für Hygiene und Mikrobiologie, Universitat Wurzburg, Germany
Microbiology 142:907-14. 1996Almost all clinical enterohaemorrhagic Escherichia coli (EHEC) O157:H7 isolates harbour a large virulence plasmid designated pO157. In this study, pO157 of EHEC O157:H7 reference strain EDL 933 was characterized at the molecular level...
- Isolation and characterization of a gene involved in hemagglutination by an avian pathogenic Escherichia coli strainD L Provence
Department of Biology, Washington University, St Louis, Missouri 63130
Infect Immun 62:1369-80. 1994..the isolation and characterization of a gene that may be important in the adherence of avian pathogenic Escherichia coli to the avian respiratory tract. The E...
- The newly characterized colicin Y provides evidence of positive selection in pore-former colicin diversificationM A Riley
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06511, USA
Microbiology 146:1671-7. 2000..have been proposed in the process of protein diversification of the large family of antimicrobial toxins of Escherichia coli, known as the colicins...
- Prevalence of ColE1-like plasmids and colicin K production among uropathogenic Escherichia coli strains and quantification of inhibitory activity of colicin KMatija Rijavec
Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, Ljubljana, Slovenia
Appl Environ Microbiol 73:1029-32. 2007Colicin K exhibited pronounced inhibitory activity against uropathogenic Escherichia coli (UPEC) strains...
- Site-specific recombination promotes linkage between trimethoprim- and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21L Sundstrom
Department of Pharmaceutical Microbiology, Uppsala University, Sweden
Mol Gen Genet 213:191-201. 1988..Similar structures were found at the 3' ends of the antibiotic resistance genes in Tn7, which could indicate similar recombination mechanisms to be effective in the evolutionary construction of all these different resistance elements...
- Diversity and relative strength of tandem promoters for the antibiotic-resistance genes of several integronsC Levesque
Departement de Biochimie, Faculte des sciences et de genie, Universite Laval, Ste Foy, Quebec, Canada
Gene 142:49-54. 1994..The strongest promoter is the version (TTGACAN17TAAACT) found in plasmid R388 and in transposon Tn1696. This promoter is six times more efficient than the derepressed tac promoter...
- Gene cassettes: a new class of mobile elementG D Recchia
CSIRO Division of Biomolecular Engineering, Sydney Laboratory, North Ryde, NSW, Australia
Microbiology 141:3015-27. 1995
- Pathogenicity island sequences of pyelonephritogenic Escherichia coli CFT073 are associated with virulent uropathogenic strainsJ S Kao
Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore 21201, USA
Infect Immun 65:2812-20. 1997Urinary tract infection is the most frequently diagnosed kidney and urologic disease, and Escherichia coli is by far the most common etiologic agent...
- Genomic analysis of a pathogenicity island in uropathogenic Escherichia coli CFT073: distribution of homologous sequences among isolates from patients with pyelonephritis, cystitis, and Catheter-associated bacteriuria and from fecal samplesD M Guyer
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Infect Immun 66:4411-7. 1998Urinary tract infection is the most frequently diagnosed kidney and urologic disease and Escherichia coli is by far the most common etiologic agent...
- The large plasmids of Shiga-toxin-producing Escherichia coli (STEC) are highly variable genetic elementsW Brunder
Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Germany
Microbiology 145:1005-14. 1999Shiga-toxin-producing Escherichia coli (STEC) of different serotypes are known to harbour large plasmids...
- Genetic structure and distribution of four pathogenicity islands (PAI I(536) to PAI IV(536)) of uropathogenic Escherichia coli strain 536Ulrich Dobrindt
Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, D 97070 Wurzburg, Germany
Infect Immun 70:6365-72. 2002For the uropathogenic Escherichia coli strain 536 (O6:K15:H31), the DNA sequences of three pathogenicity islands (PAIs) (PAI I(536) to PAI III(536)) and their flanking regions (about 270 kb) were determined to further characterize the ..
- Identification of pathogen-specific and conserved genes expressed in vivo by an avian pathogenic Escherichia coli strainCharles M Dozois
Department of Biology, Washington University, Campus Box 1137, One Brookings Drive, St Louis, MO 63130, USA
Proc Natl Acad Sci U S A 100:247-52. 2003b>Escherichia coli is a diverse bacterial species that comprises commensal nonpathogenic strains such as E. coli K-12 and pathogenic strains that cause a variety of diseases in different host species. Avian pathogenic E...
- A SitABCD homologue from an avian pathogenic Escherichia coli strain mediates transport of iron and manganese and resistance to hydrogen peroxideMourad Sabri
Institut National de la Recherche Scientifique, INRS Institut Armand Frappier, 531 Boul des Prairies, Laval, Quebec, Canada H7V 1B7
Microbiology 152:745-58. 2006..ion transporters, homologous to Salmonella enterica SitABCD, has been identified in the avian pathogenic Escherichia coli (APEC) strain chi7122...
- Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coliJean Michel Real
INSERM, U627, Faculte de Medecine, 28 Avenue de Valombrose, F 06107 Nice cedex 2, France
Cytokine 37:22-5. 2007b>Escherichia coli are the most common etiological agents of urinary tract infections (UTIs). Uropathogenic E. coli (UPECs) produce specific toxins including the cytotoxic necrotizing factor-1 (CNF1) and the alpha-hemolysin (alpha-Hly)...
- Risk factors for and outcomes of bloodstream infection caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species in childrenTheoklis E Zaoutis
Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatrics 115:942-9. 2005The increasing prevalence of infections caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species (ESBL-EK) has become a growing concern in the hospitalized patient population...
- 99mTc-labeled antimicrobial peptide ubiquicidin (29-41) accumulates less in Escherichia coli infection than in Staphlococcus aureus infectionMuhammad Saeed Akhtar
Punjab Institute of Nuclear Medicine, Faisalabad, Pakistan
J Nucl Med 45:849-56. 200499mTc-Labeled antimicrobial peptide ubiquicidin, (99m)Tc-UBI (29-41) in a freeze-dried kit, was evaluated as a bacterial infection-seeking agent in Staphlococcus aureus- and Escherichia coli-induced infections.
- Rapid identification of protein biomarkers of Escherichia coli O157:H7 by matrix-assisted laser desorption ionization-time-of-flight-time-of-flight mass spectrometry and top-down proteomicsClifton K Fagerquist
Western Regional Research Center, Agricultural Research Service, U S Department of Agriculture, 800 Buchanan Street, Albany, California 94710, USA
Anal Chem 82:2717-25. 2010Six protein biomarkers from two strains of Escherichia coli O157:H7 and one non-O157:H7, nonpathogenic strain of E...
- Expression in Escherichia coli of Y5-mutant and N-terminal domain-deleted DNA gyrase B proteins affects strongly plasmid maintenanceL Brino
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, France
Plasmid 38:188-201. 1997b>Escherichia coli DNA gyrase B subunit (GyrB) is composed of a 43-kDa N-terminal domain containing an ATP-binding site and a 47-kDa C-terminal domain involved in the interaction with the gyrase A subunit (GyrA)...
- Expression in Escherichia coli of Y5 mutant and N-terminal domain-deleted DNA gyrase B proteins affects strongly plasmid maintenanceL Brino
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
Plasmid 39:21-34. 1998b>Escherichia coli DNA gyrase B subunit (GyrB) is composed of a 43-kDa N-terminal domain containing an ATP-binding site and a 47-kDa C-terminal domain involved in the interaction with the gyrase A subunit (GyrA)...
- Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxinT K Sixma
BIOSON Research Institute, University of Groningen, The Netherlands
J Mol Biol 230:890-918. 1993Heat-labile enterotoxin (LT) from Escherichia coli is a bacterial protein toxin with an AB5 multimer structure, in which the B pentamer has a membrane binding function and the A subunit is needed for enzymatic activity...
- Genetic interactions between the Escherichia coli umuDC gene products and the beta processivity clamp of the replicative DNA polymeraseM D Sutton
Biology Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Bacteriol 183:2897-909. 2001The Escherichia coli umuDC gene products encode DNA polymerase V, which participates in both translesion DNA synthesis (TLS) and a DNA damage checkpoint control...
- Linkage between fructose 1,6-bisphosphate binding and the dimer-tetramer equilibrium of Escherichia coli glycerol kinase: critical behavior arising from change of ligand stoichiometryPeng Yu
Department of Biochemistry and Biophysics, Center for Advanced Biomolecular Research, Texas A and M University, College Station, Texas 77843 2128, USA
Biochemistry 42:4243-52. 2003b>Escherichia coli glycerol kinase (EC 2.7.1...
- The Escherichia coli BarA-UvrY two-component system is a virulence determinant in the urinary tractHenrik Tomenius
Swedish Institute for Infectious Disease Control, SE 17182 Solna, Sweden
BMC Microbiol 6:27. 2006..and the Pseudomonas spp GacS-GacA all belong to the same orthologous family of two-component systems as the Escherichia coli BarA-UvrY...
- An activator of glutamate decarboxylase genes regulates the expression of enteropathogenic Escherichia coli virulence genes through control of the plasmid-encoded regulator, PerS Shin
Center for Vaccine Development and Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 W Baltimore St, Baltimore, MD 21201, USA
Mol Microbiol 41:1133-50. 2001Enteropathogenic Escherichia coli (EPEC) is a major cause of infantile diarrhoea in a number of developing countries and is the prototype of pathogenic bacteria that cause attaching and effacing (A/E) intestinal lesions...
- Effects of heat stress on the antimicrobial drug resistance of Escherichia coli of the intestinal flora of swineM H Moro
Department of Microbiology, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA
J Appl Microbiol 88:836-44. 2000The effects of heat stress on the antimicrobial drug resistance of Escherichia coli of the intestinal tract of swine were studied in animals from a farm that had not been supplementing antimicrobials in feed for the past 10 years...
- New enterovirulent Escherichia coli serogroup 64474 showing antigenic and genotypic relationships to Shigella boydii 16Armando Navarro
Departamento de Salud Publica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico City DF 04510, Mexico
J Med Microbiol 59:453-61. 2010Studies based on the analysis of housekeeping genes indicate that Escherichia coli and all Shigella species, except for Shigella boydii type 13, belong to a single species...
- Valyl-tRNA synthetase from Escherichia coli MALDI-MS identification of the binding sites for L-valine or for noncognate amino acids upon qualitative comparative labeling with reactive amino-acid analogsC Hountondji
Laboratoire de Biochimie CNRS UMR 7654, Ecole Polytechnique, Palaiseau, France
Eur J Biochem 267:4789-98. 2000..These reagents were used for qualitative comparative labeling of Escherichia coli valyl-tRNA synthetase (ValRS), an enzyme with Val/Ile editing activity, in order to identify the binding ..
- Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: correlation with preserved circulating catecholaminesHeather Macarthur
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, MO, USA
Crit Care Med 31:237-45. 2003..Here we examined if maintenance of serum catecholamine levels by the superoxide dismutase mimetic, M40401, modulates serum cytokine levels and arterial hypotension in an Escherichia coli-infected conscious rat model of septic shock.
- Safety of raw meat and shellfish in Vietnam: an analysis of Escherichia coli isolations for antibiotic resistance and virulence genesThi Thu Hao Van
Biotechnology and Environmental Biology, School of Applied Sciences, RMIT University, Bundoora West Campus, Bundoora, Melbourne, VIC 3083, Australia
Int J Food Microbiol 124:217-23. 2008This study was conducted to examine a current baseline profile of antimicrobial resistance and virulence of Escherichia coli isolated from foods commonly sold in the market place in Vietnam. E...
- Comparison between the growth of Yersinia enterocolitica, listeria monocytogenes, escherichia coli O157:H7 and salmonella spp. in ground beef packed by three commercially used packaging techniquesH Nissen
MATFORSK, Norwegian Food Research Institute, Oslovn
Int J Food Microbiol 59:211-20. 2000Growth of the pathogens Yersinia enterocolitica, Listeria monocytogenes, Escherichia coli O157:H7 and strains of Salmonella were compared in ground beef packed in modified atmospheres of 60% CO2/40% N2/0...
- Prevalent phenotypes and antibiotic resistance in Escherichia coli and Klebsiella pneumoniae at an Indian tertiary care hospital: plasmid-mediated cefoxitin resistanceM Shahid
Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
Int J Infect Dis 12:256-64. 2008..Due to increased transcontinental movement of the human population, it would be wise to know the prevalence and resistance complexity of these strains, well in advance, in order to formulate a policy for empirical therapy...
- The catalytic, glycosyl transferase and acyl transferase modules of the cell wall peptidoglycan-polymerizing penicillin-binding protein 1b of Escherichia coliM Terrak
Centre d Ingénierie des Protéines, Universite de Liege, Institut de Chimie, B6, B 4000 Sart Tilman Liège, Belgium
Mol Microbiol 34:350-64. 1999The penicillin-binding protein (PBP) 1b of Escherichia coli catalyses the assembly of lipid-transported N-acetyl glucosaminyl-beta-1, 4-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-(L)-meso-diaminopimelyl+ ++- (L)-D-alanyl-D-alanine ..
- Comparison of Escherichia coli and Klebsiella pneumoniae liver abscessesShiuan Chih Chen
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
Am J Med Sci 334:97-105. 2007b>Escherichia coli and Klebsiella pneumoniae are the most common causative pathogens of pyogenic liver abscesses...
- Heterogeneity in enterohemorrhagic Escherichia coli O157:H7 fecal shedding in cattle is related to Escherichia coli O157:H7 colonization of the small and large intestineDanica Baines
Lethbridge Research Centre, Agriculture and Agri Food Canada, Lethbridge, ABT1J4B1, Canada
Can J Microbiol 54:984-95. 2008In the last decade, Escherichia coli O157:H7 have emerged as important pathogens of the gastrointestinal tract of humans. Healthy cattle have been identified as the primary reservoir, however, the factors affecting heterogeneous E...
- Evaluation of antibacterial activity of selected Iranian essential oils against Staphylococcus aureus and Escherichia coli in nutrient broth mediumMohammad Mohsenzadeh
Department of Food Hygiene and Public Health, Ferdowsi University of Mashhad, P O Box 91775 1793, Mashhad, Iran
Pak J Biol Sci 10:3693-7. 2007..Artmesia dracunculus) and pennyroyal (Mentha pullegium) essential oils on the Staphylococcus aureus and Escherichia coli was studied in nutrient broth medium...
- Evaluation of fermentation, drying, and/or high pressure processing on viability of Listeria monocytogenes, Escherichia coli O157:H7, Salmonella spp., and Trichinella spiralis in raw pork and Genoa salamiAnna C S Porto-Fett
U S Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Microbial Food Safety Research Unit, 600 East Mermaid Lane, Wyndmoor, PA 19038, USA
Int J Food Microbiol 140:61-75. 2010..of fermentation, drying, and high pressure processing (HPP) to inactivate Listeria monocytogenes, Escherichia coli O157:H7, Salmonella spp., and Trichinella spiralis in Genoa salami produced with trichinae-infected pork...
- Comparative enzymatic properties of GapB-encoded erythrose-4-phosphate dehydrogenase of Escherichia coli and phosphorylating glyceraldehyde-3-phosphate dehydrogenaseS Boschi-Muller
Laboratoire d Enzymologie et de Génie Génétique, Universite de Nancy I, URA CNRS 457, B P 239, 54506 Vandoeuvre les Nancy Cedex, France
J Biol Chem 272:15106-12. 1997GapB-encoded protein of Escherichia coli and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) share more than 40% amino acid identity...
- Effects of mucin and its carbohydrate constituents on Escherichia coli O157 growth in batch culture fermentations with ruminal or fecal microbial inoculumJ T Fox
Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan 66506, USA
J Anim Sci 87:1304-13. 2009In cattle, Escherichia coli O157 generally persists in the large intestine more often than in the rumen. In contrast to the rumen, the large intestine is lined by an epithelial membrane that secretes mucus...
- Binding of Escherichia coli primary replicative helicase DnaB protein to single-stranded DNA. Long-range allosteric conformational changes within the protein hexamerM J Jezewska
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch at Galveston 77555 1053, USA
Biochemistry 35:2129-45. 1996Quantitative analyses of the interactions of the Escherichia coli primary replicative helicase DnaB protein with single-stranded DNA have been performed using the thermodynamically rigorous fluorescence titration technique...
- Effective medicinal plants against enterohaemorrhagic Escherichia coli O157:H7Supayang Voravuthikunchai
School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, Australia
J Ethnopharmacol 94:49-54. 2004..of subinhibitory concentrations of antibiotics on the production of verocytotoxin (VT) by enterohaemorrhagic Escherichia coli (EHEC) O157:H7 has been claimed...
- Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptorsG Unden
Institut für Mikrobiologie und Weinforschung, Universitat Mainz, Germany
Biochim Biophys Acta 1320:217-34. 1997The electron-transport chains of Escherichia coli are composed of many different dehydrogenases and terminal reductases (or oxidases) which are linked by quinones (ubiquinone, menaquinone and demethylmenaquinone)...
- Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysisG Waksman
Laboratory of Molecular Biophysics, Rockefeller University, New York, NY 10021
J Mol Biol 236:800-16. 1994The crystal structures of three forms of Escherichia coli thioredoxin reductase have been refined: the oxidized form of the wild-type enzyme at 2...
- [Selective screening of enterohemorrhagic Escherichia coli depending on hemolysis on Beutin's washed sheep blood agar plates]N Kimura
Ishikawa Health Service Association
Kansenshogaku Zasshi 72:223-30. 1998..et al have studied hemolysin production in a large number of serologically diverse verotoxin (VT) producing Escherichia coli (VTEC) strains and found a close association between hemolysin production and VT production...
- A comparison of mutation spectra detected by the Escherichia coli lac(+) reversion assay and the Salmonella typhimurium his(+) reversion assayT Ohta
School of Life Science, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
Mutagenesis 15:317-23. 2000Each of the Escherichia coli tester strains in the WP3101P-WP3106P series contains an F' plasmid with a different base substitution mutation within the lacZ gene...
- Polyamine stress at high pH in Escherichia coli K-12Elizabeth Yohannes
Department of Biology, Kenyon College, Gambier, OH 43022, USA
BMC Microbiol 5:59. 2005Polyamines such as spermine and spermidine are required for growth of Escherichia coli; they interact with nucleic acids, and they bind to ribosomes...
- Mode of selectivity in cyclic AMP receptor protein-dependent promoters in Escherichia coliE A Pyles
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77556 1055, USA
Biochemistry 35:1162-72. 1996b>Escherichia coli cAMP receptor protein (CRP) controls more than 20 genes. There are significant differences in the promoter regions in these genes...
- Kinetic mechanism of DNA binding and DNA-induced dimerization of the Escherichia coli Rep helicaseK P Bjornson
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Biochemistry 35:2268-82. 1996The monomeric Escherichia coli Rep protein undergoes a DNA-induced dimerization upon binding either single-stranded (ss) or duplex DNA with the dimer being the active form of the Rep helicase...
- Microbial source tracking by DNA sequence analysis of the Escherichia coli malate dehydrogenase geneKathryn M Ivanetich
University of California San Francisco, Biomolecular Resource Center and Department of Pharmaceutical Chemistry, Surge 104, 90 Medical Center Way, San Francisco, CA 94143 0541, USA
J Microbiol Methods 67:507-26. 2006..of microbial organisms by DNA sequencing proposed by Olive and Bean were applied to several genes in Escherichia coli to identify targets for the development of microbial source tracking assays...
- Probing the role of tightly bound phosphoenolpyruvate in Escherichia coli 3-deoxy-d-manno-octulosonate 8-phosphate synthase catalysis using quantitative time-resolved electrospray ionization mass spectrometry in the millisecond time rangeZhili Li
Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Anal Biochem 343:35-47. 2005b>Escherichia coli 3-deoxy-D-manno-octulosonate 8-phosphate (KDO8P) synthase catalyzes the condensation of phosphoenolpyruvate (PEP) and D-arabinose 5-phosphate (A5P) to produce KDO8P and inorganic phosphate...
- Perineal swabs reveal effect of super shedders on the transmission of Escherichia coli O157:H7 in commercial feedlotsT P Stephens
Alberta Agriculture and Rural Development, Agriculture Centre, 100, 5401 1st Avenue South, Lethbridge, Alberta, Canada T1J 4V6
J Anim Sci 87:4151-60. 2009Cattle that shed more than 10(4) cfu/g of Escherichia coli O157 in feces have been described as super shedders (SS) and are thought to have major impacts on prevalence and transmission of this organism...
- Hemolytic-Uremic Syndrome and Escherichia coli O121 at a Lake in Connecticut, 1999T A McCarthy
Epidemic Intelligence Service, Connecticut Department of Public Health, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Pediatrics 108:E59. 2001Non-O157 Shiga toxin-producing Escherichia coli (STEC) have emerged as an important public health problem. Outbreaks attributed to non-O157 STEC rarely are reported...
- Evaluation of techniques for enrichment and isolation of Escherichia coli O157:H7 from artificially contaminated sproutsS D Weagant
Pacific Regional Laboratory Northwest, US Food and Drug Administration, Bothell, WA 98021, USA
Int J Food Microbiol 71:87-92. 2001..have high levels of nutrients, and a neutral pH, they are subject to the outgrowth of pathogens such as Escherichia coli O157:H7...
- Asparagine 394 in putative helix 11 of the galactose-H+ symport protein (GalP) from Escherichia coli is associated with the internal binding site for cytochalasin B and sugarT P McDonald
Department of Biochemistry and Molecular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom
J Biol Chem 272:15189-99. 1997The galactose-H+ symport protein (GalP) of Escherichia coli is very similar to the human glucose transport protein, GLUT1, and both contain a highly conserved Asn residue in predicted helix 11 that is different in a cytochalasin B-..
- [Antibacterial actin of vinegar against food-borne pathogenic bacteria including Escherichia coli O157:H7 (Part 2). Effect of sodium chloride and temperature on bactericidal activity]E Entani
Nakano Central Research Institute of Nakano Vinegar Co. Ltd
Kansenshogaku Zasshi 71:451-8. 1997..5% acidity) on food-borne pathogenic bacteria including Escherichia coli O157:H7 and other bacteria were examined. the order of bactericidal activities was NIHAIZU (3...
- Impact of empiric antimicrobial therapy on outcomes in patients with Escherichia coli and Klebsiella pneumoniae bacteremia: a cohort studyKerri A Thom
Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
BMC Infect Dis 8:116. 2008..whether appropriate empiric antimicrobial therapy improves outcomes in patients with bacteremia due to Escherichia coli or Klebsiella...
- Prevalence of enteropathogenic Escherichia coli in naturally occurring cases of poult enteritis-mortality syndromeS Pakpinyo
Department of Farm Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
Avian Dis 46:360-9. 2002Enteropathogenic Escherichia coli (EPEC) previously were identified in poult enteritis-mortality syndrome (PEMS)-affected turkeys and associated as a cause of this disease...
- Rare codon content affects the solubility of recombinant proteins in a codon bias-adjusted Escherichia coli strainGermán L Rosano
Molecular Biology Division, Instituto de Biologia Molecular y Celular de Rosario IBR, CONICET, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina
Microb Cell Fact 8:41. 2009The expression of heterologous proteins in Escherichia coli is strongly affected by codon bias. This phenomenon occurs when the codon usage of the mRNA coding for the foreign protein differs from that of the bacterium...
- [Investigation of bactericidal effect and nitric oxide responses of Caco-2 epithelial cells and THP-1 macrophage cells against Streptococcus pyogenes and Escherichia coli]Derya Biriken Salin
Ankara Üniversitesi Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Ankara
Mikrobiyol Bul 43:373-81. 2009..Therefore, Streptococcus pyogenes and Escherichia coli activated Caco-2 cells and THP-1 macrophage-like cells were investigated for their bactericidal activities ..
- Growth performance and gastrointestinal microbial ecology responses of piglets receiving Saccharomyces cerevisiae fermentation products after an oral challenge with Escherichia coli (K88)E Kiarie
Department of Animal Science, Winnipeg, Manitoba R3T 2N2, Canada
J Anim Sci 89:1062-78. 2011..on growth performance and gastrointestinal (GIT) microbial ecology in 90 weanling pigs orally challenged with Escherichia coli K88(+) (ETEC) were investigated...
- On the multiple functional roles of the active site histidine in catalysis and allosteric regulation of Escherichia coli glucosamine 6-phosphate deaminaseG M Montero-Morán
Departamento de Bioquimica, Laboratorio de Fisicoquímica y Diseño de Proteínas, Facultad de Medicina, Universidad Nacional Autonoma de Mexico UNAM, P O Box 70 159, Mexico City 04510, D F, Mexico
Biochemistry 40:10187-96. 2001The active site of glucosamine-6-phosphate deaminase (EC 126.96.36.199, formerly 188.8.131.52) from Escherichia coli was first characterized on the basis of the crystallographic structure of the enzyme bound to the competitive inhibitor 2-amino-2-..
- Influence of colostrum deprivation and concurrent Cryptosporidium parvum infection on the colonization and persistence of Escherichia coli O157 : H7 in young lambsR M La Ragione
Department of Food and Environmental Safety, Veterinary Laboratories Agency Weybridge, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
J Med Microbiol 55:819-28. 2006b>Escherichia coli O157 : H7 and Cryptosporidium parvum infections of man have been associated with direct contact with small ruminants...
- Quantitative resistance level (MIC) of bacterial pathogens (Escherichia coli, Pasteurella multocida, Pseudomonas aeruginosa, Salmonella sp., Staphylococcus aureus) isolated from chickens and turkeys: national resistance monitoring by the BVL 2004/2005Jürgen Wallmann
Federal Office of Consumer Protection and Food Safety BVL, Berlin, Germany
Berl Munch Tierarztl Wochenschr 120:452-63. 2007In the study 2004/2005, the current quantitative resistance level of Escherichia coli, Pasteurella multocida, Pseudomonas aeruginosa, Salmonella sp...
- Modeling the survival of Escherichia coli O157:H7, Listeria monocytogenes, and Salmonella Typhimurium during fermentation, drying, and storage of soudjouk-style fermented sausageCheng An Hwang
Microbial Food Safety Research Unit, Eastern Regional Research Center, Agricultural Research Service, U S Department of Agriculture, 600 E Mermaid Lane, Wyndmoor, PA 19038, USA
Int J Food Microbiol 129:244-52. 2009This study quantified and modeled the survival of Escherichia coli O157:H7, Listeria monocytogenes and Salmonella Typhimurium in soudjouk-style fermented sausage during fermentation, drying, and storage...
- Role of Asp222 in the catalytic mechanism of Escherichia coli aspartate aminotransferase: the amino acid residue which enhances the function of the enzyme-bound coenzyme pyridoxal 5'-phosphateT Yano
Department of Medical Chemistry, Osaka Medical College, Japan
Biochemistry 31:5878-87. 1992..This residue of Escherichia coli aspartate aminotransferase was replaced by Ala, Asn, or Glu by site-directed mutagenesis...
- RNA chain initiation by Escherichia coli RNA polymerase. Structural transitions of the enzyme in early ternary complexesB Krummel
Department of Biochemistry, University of California, Berkeley 94720
Biochemistry 28:7829-42. 1989We have studied the properties and structures of a series of Escherichia coli RNA polymerase ternary complexes formed during the initial steps of RNA chain initiation and elongation...
- Mechanism of carbamoyl phosphate synthetase from Escherichia coli--binding of the ATP molecules used in the reaction and sequestration by the enzyme of the ATP molecule that yields carbamoyl phosphateV Rubio
Instituto de Investigaciones Citológicas FVIB CSIC, Valencia, Spain
Eur J Biochem 255:262-70. 1998..of ATP that are involved in the overall reaction catalyzed by carbamoyl-phosphate synthetase (CPS) of Escherichia coli, and a mechanism recently proposed for this reaction, has led us to reexamine ATP binding using pulse/chase ..
- Evaluation of the NCCLS extended-spectrum beta-lactamase confirmation methods for Escherichia coli with isolates collected during Project ICAREFred C Tenover
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Clin Microbiol 41:3142-6. 2003To determine whether confirmatory tests for extended-spectrum beta-lactamase (ESBL) production in Escherichia coli are necessary, we selected 131 E...
- Influence of dietary endophyte (Neotyphodium coenophialum)-infected tall fescue (Festuca arundinacea) seed on fecal shedding of antibiotic resistance-selected Escherichia coli O157:H7 in ewesM L Looper
USDA ARS, Dale Bumpers Small Farms Research Center, Booneville, AR 72927, USA
J Anim Sci 85:1102-8. 2007..fescue seed (Festuca arundinacea, cultivar 'Kentucky 31') on fecal shedding and intestinal concentrations of Escherichia coli O157:H7 and the concentrations of prolactin, cortisol, and NEFA in experimentally inoculated ewes...
- Transport of Escherichia coli in 25 m quartz sand columnsG Lutterodt
UNESCO IHE Institute for Water Education, P O Box 3015, 2601 DA Delft, The Netherlands
J Contam Hydrol 119:80-8. 2011..experiments were conducted to measure the distant dependent sticking efficiencies of two low attaching Escherichia coli strains (UCFL-94 and UCFL-131)...
- Kinetic mechanism of adenine nucleotide binding to and hydrolysis by the Escherichia coli Rep monomer. 2. Application of a kinetic competition approachK J Moore
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110
Biochemistry 33:14565-78. 1994The Escherichia coli Rep protein is a DNA helicase that functions as a homodimer to catalyze the unwinding of duplex DNA during DNA replication in a reaction that is coupled to the binding and hydrolysis of ATP...
- Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptideRobert M Cicchillo
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Biochemistry 43:11770-81. 2004..However, the exact identity of the sulfur donor remains unknown. We report herein that LS from Escherichia coli can accommodate two [4Fe-4S] clusters per polypeptide and that this form of the enzyme is relevant to ..
- Serotypes, virulence genes and intimin types of Shiga toxin (verocytotoxin)-producing Escherichia coli isolates from minced beef in Lugo (Spain) from 1995 through 2003Azucena Mora
Laboratorio de Referencia de E coli, Departamento de Microbioloxia e Parasitoloxia, Universidade de Santiago de Compostela USC, 27002 Lugo, Spain
BMC Microbiol 7:13. 2007Shiga toxin-producing Escherichia coli (STEC) have emerged as pathogens that can cause food-borne infections and severe and potentially fatal illnesses in humans, such as haemorrhagic colitis (HC) and haemolytic uraemic syndrome (HUS)...
- [Evolution of Escherichia coli antibiotic resistances in urine samples from the community]Jose Maria Sanchez Merino
Servicio de Urologia, Hospital El Bierzo, Ponferrada, Leon, Espana
Arch Esp Urol 61:776-80. 2008The objectives of this work are two: first, to evaluate the resistance of Escherichia coli to several antibiotics and their trends over a six-year period in strands isolated in urine samples from patients receiving health-care in general ..
- Control of Escherichia coli O157:H7 in corn silage with or without various inoculants: efficacy and mode of actionA F Pedroso
Department of Animal Sciences, Institute of Food and Agricultural Sciences, University of Florida, Gainesville 32606, USA
J Dairy Sci 93:1098-104. 2010This study aimed to evaluate the effectiveness of 3 commercial bacterial inoculants at controlling Escherichia coli O157:H7 in corn silages during ensiling and feedout phases of silage production...
- Differential effects of temperature and hydrostatic pressure on the formation of quinonoid intermediates from L-Trp and L-Met by H463F mutant Escherichia coli tryptophan indole-lyaseRobert S Phillips
Department of Chemistry, University of Georgia, Athens, Georgia 30602 2556, USA
Biochemistry 44:14289-97. 2005b>Escherichia coli tryptophan indole-lyase (Trpase) is a bacterial pyridoxal 5'-phosphate (PLP)-dependent enzyme which catalyzes the reversible beta-elimination of l-Trp to give indole and ammonium pyruvate. H463F mutant E...
- Multiple seropathotypes of verotoxin-producing Escherichia coli (VTEC) disrupt interferon-gamma-induced tyrosine phosphorylation of signal transducer and activator of transcription (Stat)-1Narveen Jandu
Research Institute, Hospital for Sick Children, Ont, Canada
Microb Pathog 42:62-71. 2007Verotoxin-producing Escherichia coli (VTEC) O157:H7 inhibits interferon-gamma-stimulated tyrosine phosphorylation of signal transducer and activator of transcription (Stat)-1 in epithelial cells, independent of Verotoxins and the locus of ..
- The ferredoxin:sulphite reductase gene from Synechococcus PCC7942G Gisselmann
Biochemistry of Plants, Faculty of Biology, Ruhr University Bochum, Germany
Biochim Biophys Acta 1144:102-6. 1993..The gene termed 'sir' was detected by heterologous Southern hybridisation with the structural gene cysI from Escherichia coli encoding the iron-sulphur haemoprotein of the NADPH:sulphite reductase...
- Evidence for chloramphenicol/H+ antiport in Cmr (MdfA) system of Escherichia coli and properties of the antiporterT Mine
Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700 8530, Japan
J Biochem 124:187-93. 1998We detected chloramphenicol/H+ antiport activity in membrane vesicles of Escherichia coli and cloned a gene for the antiporter from chromosomal DNA of E. coli. Introduction of the gene into E...
- Oxygen-dependent coproporphyrinogen III oxidase (HemF) from Escherichia coli is stimulated by manganeseDaniela Breckau
Institute of Microbiology, Technical University Braunschweig, Spielmannstrasse 7, D 38106 Braunschweig, Germany
J Biol Chem 278:46625-31. 2003During heme biosynthesis in Escherichia coli two structurally unrelated enzymes, one oxygen-dependent (HemF) and one oxygen-independent (HemN), are able to catalyze the oxidative decarboxylation of coproporphyrinogen III to form ..
- An unusual signal peptide facilitates late steps in the biogenesis of a bacterial autotransporterRose L Szabady
Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 102:221-6. 2005..In this study, we used the Escherichia coli O157:H7 autotransporter EspP as a model protein to investigate the function of the unusual signal peptides...
- A pilot clinical trial of a recombinant ricin vaccine in normal humansEllen S Vitetta
Cancer Immunobiology Center, Aston Center, Department of Microbiology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 103:2268-73. 2006..This mutant recombinant RTA (named RiVax) was expressed and produced in Escherichia coli and purified. When RiVax was injected i.m. into mice it protected them against a ricin challenge of 10 LD50s...
- One-step purification of bacterially expressed recombinant transducin alpha-subunit and isotopically labeled PDE6 gamma-subunit for NMR analysisLian Wang Guo
Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA
Protein Expr Purif 51:187-97. 2007..of recombinant Galpha(t) (rGalpha(t)) and homogeneous and functional isotopically labeled PDEgamma from Escherichia coli cells...
- Streptococcus agalactiae GAPDH is a virulence-associated immunomodulatory proteinPedro Madureira
ICBAS Instituto de Ciências Biomédicas de Abel Salazar, Porto, Portugal
J Immunol 178:1379-87. 2007..The gapC gene was cloned and expressed in Escherichia coli for the production of a recombinant histidyl-tagged protein...
- Compact disk (CD)-shaped device for single cell isolation and PCR of a specific gene in the isolated cellShunsuke Furutani
Department of Bioinformatics, Graduate School of Engineering, Soka University, 1 236 Tangi, Hachioji, Tokyo 192 8577, Japan
Anal Bioanal Chem 398:2997-3004. 2010..Selective detection of S. enterica was achieved by PCR from a mixture of S. enterica and Escherichia coli on the CD-shaped device.
- Electrochemical detection of nicotinamide adenine dinucleotide based on molecular beacon-like DNA and E. coli DNA ligaseXiaoxiao He
State Key Laboratory of Chemo Biosensing and Chemometrics, College of Biology, Hunan University, Changsha 410082, PR China
Talanta 83:937-42. 2011..with high sensitivity and selectivity has been developed by using molecular beacon (MB)-like DNA and Escherichia coli DNA ligase...
- Two oppositely oriented arrays of low-affinity recognition sites in oriC guide progressive binding of DnaA during Escherichia coli pre-RC assemblyTania A Rozgaja
Department of Biological Sciences, Florida Institute of Technology, 150 W University Blvd, Melbourne, FL 32901, USA
Mol Microbiol 82:475-88. 2011..We suggest that this polarized assembly of unique DnaA oligomers within oriC plays an important role in mediating pre-RC activity and may be a feature found in all bacterial replication origins...
- Strategy for stable and high-level expression of recombinant trehalose synthase in Escherichia coliPo Ting Chen
Department of Biotechnology, Southern Taiwan University, No 1, Nan Tai Street, Tainan 710, Taiwan
J Agric Food Chem 60:6063-8. 2012..attempted to overproduce trehalose synthase from Picrophilus torridus (PTTS), a thermoacidophilic archaea, in Escherichia coli ...
- LeuO is a global regulator of gene expression in Salmonella enterica serovar TyphimuriumShane C Dillon
Department of Microbiology, School of Genetics and Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland
Mol Microbiol 85:1072-89. 2012..It differed in some details from a motif that we composed for Escherichia coli LeuO binding sites; 1263 and 1094 LeuO binding site locations were predicted in the S...
- NADPH-dependent reductive biotransformation with Escherichia coli and its pfkA deletion mutant: influence on global gene expression and role of oxygen supplySolvej Siedler
Institut für Bio und Geowissenschaften, IBG 1 Biotechnologie, Forschungszentrum Julich, D 52425, Julich, Germany
Biotechnol Bioeng 111:2067-75. 2014An Escherichia coli ΔpfkA mutant lacking the major phosphofructokinase possesses a partially cyclized pentose phosphate pathway leading to an increased NADPH per glucose ratio...
- Changes in lipid distribution in E. coli strains in response to norfloxacinEmily R Schenk
Department of Chemistry and Biochemistry, Florida International University, Miami, FL, 33199, USA
J Mass Spectrom 50:88-94. 2015..In the current study, three closely related Escherichia coli strains, a wild type (MG1655) and an isogenic pair derived from the wild type (DPB635 and DPB636) are studied ..
- Recombinant Escherichia coli strains with inducible Campylobacter jejuni single domain hemoglobin CHb expression exhibited improved cell growth in bioreactor cultureLi Xu
College of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, China
PLoS ONE 10:e0116503. 2015..synthesized and functionally expressed under the control of inducible expression promoters PT7 and Pvgh in Escherichia coli. The effects of the recombinants PT7-CHb and Pvgh-CHb on cell growth were evaluated in aerobic shake flasks, ..
- Spatial and hydrologic variation of Bacteroidales, adenovirus and enterovirus in a semi-arid, wastewater effluent-impacted watershedDustin G Bambic
Department of Civil and Environmental Engineering, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA Larry Walker Associates, 707 Fourth Street Suite 200, Davis, CA 95616, USA
Water Res 75:83-94. 2015..In surface water samples with virus detections, Escherichia coli concentrations were often below (in compliance with) the recreational water quality criteria...
- Broad spectrum antimicrobial compounds from the bacterium Exiguobacterium mexicanum MSSRFS9S P Shanthakumar
Laboratory Integrated Pest Management IPM, M S Swaminathan Research Foundation, III Cross Road, Institutional Area, Taramani, Chennai 600113, Tamil Nadu, India Electronic address
Microbiol Res 178:59-65. 2015..In particular microbial pathogens like Escherichia coli, Shigella flexneri, Klebsiella pneumonia and Salmonella enterica are apparelled with systemic machineries to ..
- Characterization of β-defensin 42 expressed in principal cells at the initial segment of the rat epididymisAijie Xin
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Acta Biochim Biophys Sin (Shanghai) 47:861-9. 2015..The recombinant Defb42 was predominantly antimicrobial not against Candida albicans, but against Escherichia coli and Staphylococcus aureus...
- In Vitro and In Vivo Activities of OP0595, a New Diazabicyclooctane, against CTX-M-15-Positive Escherichia coli and KPC-Positive Klebsiella pneumoniaeAkihiro Morinaka
Meiji Seika Pharma Co, Ltd, Yokohama, Japan
Antimicrob Agents Chemother 60:3001-6. 2016..in in vitro time-kill studies and an in vivo infection model against five strains of CTX-M-15-positive Escherichia coli and five strains of KPC-positive Klebsiella pneumoniae An OP0595 concentration of 4 μg/ml was found to be ..
- On the role of the high molecular weight penicillin-binding proteins in the cell cycle of Escherichia coliF B Wientjes
Department of Molecular Cell Biology, University of Amsterdam
Res Microbiol 142:333-44. 1991Blocking of penicillin-binding proteins (PBP) 2 or 3 of Escherichia coli by specific antibiotics led to inhibition of peptidoglycan synthesis measured as rate of 3H-Dap incorporation...
- Yeast thioredoxin genesZ R Gan
Department of Biological Chemistry, Merck Sharp and Dohme Research Laboratory, West Point, Pennsylvania 19486
J Biol Chem 266:1692-6. 1991..Thioredoxins I and II show 78% amino acid sequence identity. They display more amino acid sequence similarity with mammalian thioredoxin than with Escherichia coli and plant chloroplast thioredoxins.
- Functional analysis of the sporulation-specific SPR6 gene of Saccharomyces cerevisiaeL A Kallal
Department of Biological Sciences, University of New Orleans, LA 70148
Curr Genet 18:293-301. 1990..This protein is probably produced by the yeast, because the lacZ gene of Escherichia coli is expressed during sporulation when fused to SPR6 in the expected reading frame...
- The leucine-responsive regulatory protein of Escherichia coli negatively regulates transcription of ompC and micF and positively regulates translation of ompFM Ferrario
Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 1055
J Bacteriol 177:103-13. 1995The two major porins of Escherichia coli K-12 strains, OmpC and OmpF, are inversely regulated with respect to one another...
- The yiaE gene, located at 80.1 minutes on the Escherichia coli chromosome, encodes a 2-ketoaldonate reductaseD Y Yum
Bioprocess Engineering Division, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon 305 600, Korea
J Bacteriol 180:5984-8. 1998An open reading frame located in the bisC-cspA intergenic region, or at 80.1 min on the Escherichia coli chromosome, encodes a hypothetical 2-hydroxyacid dehydrogenase, which was identified as a result of the E...
- Crystallization and preliminary X-ray studies of membrane-associated Escherichia coli dihydroorotate dehydrogenaseP Rowland
Centre for Crystallographic Studies, Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK 2100 Copenhagen O, Denmark
Acta Crystallogr D Biol Crystallogr 56:659-61. 2000..DHOD from Escherichia coli is a typical member of family 2, which contains the membrane-associated enzymes from Gram-negative bacteria ..
- S. typhimiurium Vaccine Against Bacterial EnteropathogensRoy Curtiss; Fiscal Year: 2007..2 million are the result of infections by Salmonella and other related bacterial enteropathogens including Escherichia coli and Shigella species, and less closely related enteropathogens such as Vibrio cholerae, Campylobacter jejuni ..
- Emergence of E. coli sequence type ST131James R Johnson; Fiscal Year: 2013A specific group of Escherichia coli, sequence type ST131 is a newly recognized, widely disseminated cause of multi-drug-resistant (MDR extraintestinal infections that appears to represent an important emerging health threat in urgent ..
- Rho-Modifying Cytotoxic Necrotizing Factor of E. coliALISON DAVIS O'BRIEN; Fiscal Year: 2013..CNF1 and a membrane-lytic toxin, hemolysin (Hly), are often co- expressed by Escherichia coli strains that cause urinary tract infections (UTIs), i.e., cystitis or pyelonephritis, or acute prostatitis...
- JEAN CLAIRE LEE; Fiscal Year: 2014..This protein glycosylation system has been functionally transferred into Escherichia coli, and it allows the conjugation of an antigenic polysaccharide to a designer protein of choice through an N-..
- Jeff Gelles; Fiscal Year: 2016..selected processes involved in regulation of transcription initiation and elongation in vitro using purified Escherichia coli proteins in reconstituted transcription reactions...
- Thomas J Silhavy; Fiscal Year: 2015..of this grant has always been to understand the mechanisms of envelope biogenesis in molecular terms using Escherichia coli as a model system...
- DNA-Binding Protein Discovery by the Combinatorial Method REPSAMichael van Dyke; Fiscal Year: 2013..For example, while the bacteria Escherichia coli strain K12 has 4364 open reading frames, only about half of these genes have been well characterized by ..
- Cellular functions of the essential PcrA helicase in Staphylococcus aureusSaleem A Khan; Fiscal Year: 2013..PcrA is related to the Escherichia coli UvrD and Rep helicases and is known to be essential for UV DNA repair in Bacillus subtilis. In B...
- KONSTANTIN V SEVERINOV; Fiscal Year: 2016..Neither stage of CRISPR response is fully understood. We propose to study CRISPR function in Escherichia coli, the best-studied prokaryote. CRISPR/cas loci of laboratory E. coli are dormant...
- Zucai Suo; Fiscal Year: 2014..to construct single-stranded plasmid or viral vectors and mutagenicity and genotoxicity will be evaluated in Escherichia coli and mammalian cells...
- Roy Curtiss Iii; Fiscal Year: 2014..8 (WHO) to 2.2 (UNESCO) million are due to infections with enteric pathogens including Salmonella, Escherichia coli and Shigella sp., and other entero-pathogens such as Yersinia sp...
- Gail A Hecht; Fiscal Year: 2014..Enteropathogenic Escherichia coli (EPEC) is a foodborne non-invasive pathogen that causes diarrhea...
- Robin Patel; Fiscal Year: 2015..aeruginosa, S. aureus, and S. epidermidis, three isolates each of Escherichia coli and Enterococcus faecalis, and single isolates of each of Streptococcus mutans species group and Candida ..
- Fatty acid related regulation of enteric infectious diseaseFREDRICK JON KULL; Fiscal Year: 2012..Preliminary analysis has indicated that a number of pathogenic bacteria, including several types of Escherichia coli, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, and Yersinia enterocolitica, contain A/X ..
- 4th ASM Conference on Prokaryotic Cell Biology and DevelopmentSusan S Golden; Fiscal Year: 2012..The core subject matter involves five widely and successfully studied systems: Escherichia coli (cell division, cytoskeletal structures, cell wall biosynthesis), Bacillus subtilis (cell cycle regulation, ..
- Colitis Induced by immune responses to luminal bacteria-mouseRyan B Sartor; Fiscal Year: 2012..Selective colonization of germ-free IL-10-/- mice with Escherichia coli or Enterococcus faecalis induces different phenotypes of colitis for each bacteria. E. coli and E...
- Molecular analysis of oriT-independent transfer in the gonococcal R-plasmidsLUIS TORRES-BAUZA; Fiscal Year: 2012..We found that the 5.2 kb R- plasmid isolated in San Juan, pSJ5.2, can be mobilized to Escherichia coli by fusion (cointegration) with the help of the Enterobacterial R64, N3 and the 41 kb tet(M) conjugative ..
- LIPID A MODIFICATION SYSTEMS IN GRAM-NEGATIVE BACTERIAPei Zhou; Fiscal Year: 2012..b>Escherichia coli lipid A is synthesized on the cytoplasmic surface of the inner membrane by a conserved pathway of nine ..
- Toxoid adjuvant CRM197 production in a stable reduced genome E. coli strainFrederick R Blattner; Fiscal Year: 2012DESCRIPTION (provided by applicant): Scarab Genomics has developed valuable reduced-genome strains of Escherichia coli in which multiple deletions remove from the genome much unwanted and all potentially hazardous DNA...
- Production of Activated TDP-Deoxysugars in E. coliMICAH SHEPHERD; Fiscal Year: 2012..We propose to investigate a novel approach to produce rare TDP-deoxysugars in Escherichia coli through metabolic engineering...
- REGULATION AND FUNCTION OF FIS IN E COLIRobert Osuna; Fiscal Year: 1999..In Escherichia coli, the small DNA binding protein Fis is involved in an increasing number of cellular processes that include ..
- Stomate-based innate immunity against bacterial infection in ArabidopsisMaeli Melotto; Fiscal Year: 2012..Specifically, stomata close in response to Escherichia coli O157:H7 and Pseudomonas syringae pv. tomato (Pst) DC3000 or bacterial PAMPs...
- Phylogeny, Structure and Virulence Contributions of NMEC's Virulence PlasmidsLisa K Nolan; Fiscal Year: 2013..neonatal bacterial meningitis is a major cause of mortality and morbidity worldwide with neonatal meningitis Escherichia coli (NMEC) being the most common agent of these infections...
- High-Throughput Assay Development for the Discovery of Small Molecule InhibitorsCHASE BEISEL; Fiscal Year: 2013..Aim 1: Develop primary assays to screen for small molecule inhibitors of the Hfq-binding sRNA Spot 42 in Escherichia coli. The primary assay will rely on Spot 42, although the end goal is to identify inhibitors of global sRNA ..
- Delivery of a bacterial inhibitor of NF-kB to colon tumorsPHILIP ROSS HARDWIDGE; Fiscal Year: 2012..This protein, NleH1, expressed by Escherichia coli O157:H7, binds to and inhibits the function of a newly identified subunit of NF-?B, the ribosomal protein S3 (..
- Timothy Palzkill; Fiscal Year: 2016..function will be determined by selecting functional clones from each library based on their ability to confer Escherichia coli resistance to a [unreadable]-lactam antibiotic of interest...
- CHARALAMPOS KALODIMOS; Fiscal Year: 2016..We have extensively characterized over the last years all of the protein components from Escherichia coli and have obtained and present here strong data supporting intriguing emerging hypotheses about the mechanisms ..
- Scott J Hultgren; Fiscal Year: 2015..S., ~85% of which are caused by uropathogenic Escherichia coli (UPEC)...
- DAVID ALAN HUNSTAD; Fiscal Year: 2014..UTIs), a major source of morbidity and medical costs worldwide, are caused primarily by uropathogenic Escherichia coli, which employ an adhesive fiber termed the type 1 pilus to bind and invade bladder epithelial cells...
- Yuk Ching Tse-Dinh; Fiscal Year: 2014..Priority would be given to compounds with low toxicity that are active against gram negative Escherichia coli and Yersinia pestis in order to identify leads that can be used in development of therapeutic agents against ..
- Ailong Ke; Fiscal Year: 2015..far sequenced, including important human pathogens such as Campylobacter human jejuni, Clostridium botulinum, Escherichia coli, Listeria monocytogenes, Mycobacterium tuberculosis and Yersinia pestis...
- Johan Paulsson; Fiscal Year: 2014..for different types of macromolecules: in-depth analyses of active segregation mechanisms of plasmids in Escherichia coli, a quantification of proteolysis in E. coli, and an mRNA and protein survey in Schizosaccharomyces pombe...
- NOVEL SOLUBILITY-ENHANCING PROTEIN EXPRESSION TECHNOLOGYDAVID ALAN MEAD; Fiscal Year: 2013..The most favored host for heterologous recombinant protein expression is Escherichia coli. Despite many improvements, producing soluble proteins in E...
- JAMES MICHAEL FLECKENSTEIN; Fiscal Year: 2016DESCRIPTION (provided by applicant): The enterotoxigenic Escherichia coli (ETEC) are a genetically diverse type of pathogenic E...
- Peter J Christie; Fiscal Year: 2014..faecalis donor cells to Escherichia coli recipients, and ii) a functional T4SS encoded by an 89-kilobase pathogenicity island (89K PAI) was shown to ..
- Bordetella adenylate cyclase toxin: the role of cell interaction in toxin functioJOSHUA CLARK EBY; Fiscal Year: 2013..of pore-forming bacterial protein toxins that are produced by other pathogenic bacteria such as uropathogenic Escherichia coli. Here, we will characterize the basic mechanisms of cell binding by AC toxin and show that these mechanisms ..
- Robert A Bonomo; Fiscal Year: 2014..These [unreadable]-lactamases are found in ceftazidime resistant Klebsiella pneumoniae, Escherichia coli, Enterobacter spp., Acinetobacter baumannii, and Pseudomonas aeruginosa...
- National surveillance of emerging MDR in pediatric Enterobacteriaceae infectionsDanielle M Zerr; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: We propose to study antibiotic resistance in Enterobacteriaceae bacteria (such as Escherichia coli and Klebsiella pneumoniae) that produce urinary tract and bloodstream infections in children, by analyzing ..
- Photoactivated Antimicrobial CollagenBARBARA ANN SOLTZ; Fiscal Year: 2013..Similar results were obtained for Staphylococcus aureus, MRSA, Pseudomonas aeruginosa and Escherichia coli infections...
- Discovery of Polymyxin-based Antibacterial Agents Active Against Multi-Drug ResisLawrence H Lash; Fiscal Year: 2013..In particular, the expansion of Gram-negative strains such as Klebsiella pneumonia, Escherichia coli, Acinetobacter baumannii and Pseudomonas aeruginosa and the rapidly spreading NDM-1 phenotypes are of grave ..
- Harry L Mobley; Fiscal Year: 2016..The most common uropathogen, Escherichia coli, can cause acute cystitis or pyelonephritis in the uncomplicated urinary tract...
- PRASADARAO V NEMANI; Fiscal Year: 2014DESCRIPTION (provided by applicant): Bacterial meningitis due to Escherichia coli K1 is a serious illness of the central nervous system. It is the most common pathogen causing meningitis in premature infants (46%)...
- JONATHAN JAMES HANSEN; Fiscal Year: 2014..Isolates of Escherichia coli (E...
- Johan Paulsson; Fiscal Year: 2016..design and interpret quantitative experiments for two systems that promote virulence and drug resistance in Escherichia coli. We focus on replication control of bacterial plasmids, where noise suppression is essential...
- Bacterial heme transport and hemoglobin expressionDouglas Henderson; Fiscal Year: 2009Our long-term goal is to produce large amounts of recombinant human hemoglobin in Escherichia coli to allow commercial production of the protein for formulation of hemoglobin-based oxygen carriers which will be used for blood ..
- Development of the www.EcoliCommunity.org Information ResourceBarry Wanner; Fiscal Year: 2009DESCRIPTION (provided by applicant): Basic knowledge of the biochemistry, molecular biology, and genetics of Escherichia coli K-12 may be more advanced than for any other organism...
- Catalytic inactivation of miRNA function by customized RNase P-based ribozymesDANIEL R contact SCHOENBERG; Fiscal Year: 2010..Our research design exploits the properties of M1 RNA, the catalytic subunit of Escherichia coli RNase P...
- Protein Translocation by the Type III Secretion SystemPartho Ghosh; Fiscal Year: 2010..Salmonella spp., and Escherichia coli O157:H7 among others...
- Novel Antibacterial Drugs Targeting DNA Repair EnzymesGerald R Smith; Fiscal Year: 2010..We will first screen for small-molecule inhibitors of RecBCD in Escherichia coli cells, using a simple, quick, and sensitive assay of nuclease activity in an easily grown E. coli strain...
- Monica Chander; Fiscal Year: 2014..SoxR has traditionally been known as the mediator of an oxidative stress response in Escherichia coli and Salmonella enterica, but this role may be restricted to enteric bacteria...
- Biological Effects of DNA Adducts Formed by Nitroaromatic CompoundsASHIS BASU; Fiscal Year: 2009..to construct single-stranded plasmid or viral vectors and mutagenicity and genotoxicity will be evaluated in Escherichia coli and mammalian cells...
- Validating metabolic pathways in the intracellular pathogen Chlamydia trachomatisDEREK JAMES FISHER; Fiscal Year: 2010..AroG, AroDE, and AroA) using genetic and biochemical approaches, including complementation studies in Escherichia coli null mutants, enzyme assays using purified recombinant proteins, and inhibitor assays;2) detecting chorismate ..
- A New Point of Use Decontamination Method for Fresh ProduceADRIAN J DENVIR; Fiscal Year: 2010..Foodborne illnesses in fruits and vegetables have been linked to several microbial species, including Escherichia coli O157:H7, Salmonella species, Listeria monocytogenes, Shigella species, Cyclospora cayetanensis, Hepatitis A ..
- Adherent Escherichia coli and associated virulence genes in children with IBDSandra C Kim; Fiscal Year: 2010..10 deficient (IL-10-/-) mice selectively colonized (monoassociated) with non-pathogenic strains of Escherichia coli (NC101) or Enterococcus faecalis (OG1RF) develop different phenotypes of colitis with clear regional and ..
- Epidemiology of Community-Associated, ESBL-Producing Escherichia coliYohei Doi; Fiscal Year: 2010Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli has become widespread in healthcare settings. These organisms are not only resistant to most beta-lactams but also fluoroquinolones and aminoglycosides...
- Interaction between B. cereus RecQ helicase and topoisomerase IIIZhiyu Li; Fiscal Year: 2010..Unlike many single cellular organisms, such as Escherichia coli, Saccharomyces cerevisiae, and Saccharomyces pombe, which possess one or two type IA topoisomerases and ..
- Exploiting deep ocean biology for biomedical discoveryDavid C Rowley; Fiscal Year: 2011..of both ATCC and clinical strains of multiple drug resistant Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae...
- MULTI-ANALYTE IMMUNOCHROMATOGRAPHIC TEST STRIP FOR BACTERIAL TOXIN DETECTIONTHOMAS W OWEN; Fiscal Year: 2011..For example, Escherichia coli O157:H7 infections can spread through contaminated food, contaminated drinking water, contaminated swimming ..
- A new technology for preclinical development of functional bispecific antibodiesLee A Henderson; Fiscal Year: 2010..potential of BsAbs has not been fully realized due to inefficient production methods, especially in Escherichia coli where several different BsAb formats have been met with limited success...
- Reactivity epitopes of ribonuclease III substratesALLEN WHITALL NICHOLSON; Fiscal Year: 2010..The mechanism of RNase III activation will be analyzed using an in vitro translation system. Along with Escherichia coli RNase III, this project will employ Aquifex aeolicus RNase III and Thermotoga maritima RNase III, for which ..
- MECHANISM AND CONTROL OF UREA BIOSYNTHESISFrank M Raushel; Fiscal Year: 2011..enzyme has recently been implicated in the biosynthesis of an extracellular death factor peptide, NNWNN, in Escherichia coli. The role of AsnA in the formation of this very unusual peptide will be determined...
- The novel cross-linking of the flagellar hook protein of Borrelia burgdorferiNYLES CHARON; Fiscal Year: 2012..complexes will be purified from growing cells, and recombinant Bb FlgE (rFlgE) will be synthesized in Escherichia coli and purified as described...
- Characterization of a novel ETEC virulence regulatorJOSEPH THOMAS WADE; Fiscal Year: 2012..how transcription factors (TFs) regulate virulence processes in the pathogenic species, Enterotoxigenic Escherichia coli (ETEC)...
- Novel gene-silencing therapeutics for multidrug-resistant gram-negative pathogensDAVID ELIHU GREENBERG; Fiscal Year: 2013..This group includes the Gram-negative pathogens Acinetobacter baumannii and Escherichia coli. A new paradigm in antibiotic discovery and design has recently been shown effective against numerous ..
- SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTINGShinichiro Kurosawa; Fiscal Year: 2011DESCRIPTION (provided by applicant): Shiga-like toxin producing enterohemorrhagic Escherichia coli (EHEC) strains are recognized as the most common cause of outbreaks and regional sporadic cases of bloody diarrhea and hemolytic uremic ..
- Short-term responses to temperature changes in Escherichia coliChristine A White Ziegler; Fiscal Year: 2010..molecular biology approaches to explore the short-term response of both commensal and pathogenic strains of Escherichia coli to these temperatures...
- Pathogenic Mechanisms of Shiga ToxinsVernon L Tesh; Fiscal Year: 2010Infections with Shiga toxin (Stx)-producing bacteria Shigella dysenteriae 1 and Escherichia coli cause bloody diarrheal diseases which continue to be a major public health concern in developed and developing countries...
- Bacterial gene regulation by the NTP substrates of transcription initiationCharles L Turnbough; Fiscal Year: 2013..The proposed studies will focus on Escherichia coli operons that encode proteins involved in pyrimidine biosynthesis or salvage...
- Electrochemical Method for Viable Pathogen DetectionADRIAN DENVIR; Fiscal Year: 2006..is to develop a new, automated system for the rapid detection of bacterial contamination (especially Escherichia coli O157:H7) in meat and meat products...
- TREATMENT INTERVENTIONS FOR HEMORRHAGIC COLITISEdgar Boedeker; Fiscal Year: 1999DESCRIPTION The broad aim of this application is to use a new animal model of enterohemorrhagic Escherichia coli (EHEC) infection to develop prophylactic and therapeutic regimens to prevent and treat EHEC disease...
- Molecular Modulation of Catalytic Sites of Escherichia coli F1Fo ATP SynthaseZulfiqar Ahmad; Fiscal Year: 2009..0 million kg of ATP in a 75-year life span. In its simplest form, Escherichia coli contains eight different subunits. It can be separated into two sectors F1 and Fo...
- Mechanism of Regulating Division in Escherichia coliJennifer R Juarez; Fiscal Year: 2012..For this work the model organism Escherichia coli will be used...
- SHIGA-LIKE TOXIN OF ESCHERICHIA COLIALISON O BRIEN; Fiscal Year: 1991b>Escherichia coli can cause diarrhea by several distinct mechanisms. A newly recognized group of E. coli cause hemorrhagic colitis and the hemolytic uremic syndrome. These enterohemorrhagic E...
- ESCHERICHIA COLI LT-RELATED ENTEROTOXINSRICHARD FINKELSTEIN; Fiscal Year: 1991..k.a. LTs) from diarrheagenic strains of Escherichia coli of human (H) origin; LT from strains of E. coli of porcine (P) origin; a distinct LT, LT-II, from an E...
- REGULATION BY THE ESCHERICHIA COLI SMALL RNA, DSRADARREN SLEDJESKI; Fiscal Year: 2002DsrA is a small, stable, untranslated RNA that is conserved between Escherichia coli, Klebsiella pneumoniae, and Salmonella typhimurium. DsrA RNA regulates two different global regulatory networks...
- Determining vaccine candidacy of LT and STa toxoid fusions against enterotoxigeniWeiping Zhang; Fiscal Year: 2010Enterotoxigenic Escherichia coli (ETEC) strains are categorized as priority B pathogens by NIAID...
- Glycosylation of full-length antibodies in Escherichia coliADAM FISHER; Fiscal Year: 2009..Full-length monoclonal antibodies (immunoglobulins) can be produced in Escherichia coli that are functionally similar to those produced in mammalian cells except in the ability to bind macrophage ..
- Humanizing N-linked glycosylation in Escherichia coliADAM FISHER; Fiscal Year: 2009..jejuni asparagine-linked (Nlinked) protein glycosylation system can be functionally transferred into Escherichia coli, giving the recipient E. coli cells the ability to glycosylate proteins...
- Pathogenicity of Shiga Toxin-Producing E. coliALISON O BRIEN; Fiscal Year: 2007DESCRIPTION (provided by applicant): Enterohemorrhagic Escherichia coli (EHEC) O157:H7 belongs to a subset of Shiga toxin-producing E coli (STEC) that makes Shiga toxin (Stx) type 1 or type 2 (or a variant thereof), or both toxins, ..
- DNA METHYLATION AND PILI GENE REGULATIONDavid Low; Fiscal Year: 2006..and PapI orchestrate the reversible switch between OFF and ON Pap pili expression states in uropathogenic Escherichia coli (UPEC)...
- MECHANISM OF CARBOHYDRATE TRANSPORT IN BACTERIAMilton Saier; Fiscal Year: 2000Enteric bacteria such as Escherichia coli and Salmonella species are principal causative agents of diarrhea, dysentery, urinary tract infections, meningitis in children, septicemia, enteric fevers, an pneumonia...
- GENETIC ANALYSIS TO THE SIGNAL RECOGNITION PARTICLEGregory Phillips; Fiscal Year: 1999..to components of the mammalian SRP and SRP receptor have recently been found throughout nature, including in Escherichia coli. E. coli homologues include products of the ffh, ffs, and ftsY genes. All of these genes are essential for E...
- E COLI TRANSLOCATION ACROSS INTESTINAL EPITHELIUMMichelle Pietzak; Fiscal Year: 2003..D., Dr. Pietzak will continue to pursue her basic investigations into the mechanisms by which Escherichia coli (E. coli) is able to translocate across intestinal epithelium and cause sepsis. E...
- THE CLONAL NATURE OF CYTOTOXIGENIC E. COLITHOMAS WHITTAM; Fiscal Year: 1991..research is to define the clonal population structure and genetic relationships of pathogenic forms of Escherichia coli, with special reference to cytotoxin-producing strains that only recently have been linked to enteric disease ..
- THE CLONAL NATURE OF CYTOTOXIGENIC E. COLITHOMAS WHITTAM; Fiscal Year: 1992..research is to define the clonal population structure and genetic relationships of pathogenic forms of Escherichia coli, with special reference to cytotoxin-producing strains that only recently have been linked to enteric disease ..
- VIRUL FACTORS OF UROPATH ESCHERICHIA COLIPeter Redford; Fiscal Year: 2003b>Escherichia coli is the most common cause of community-acquired urinary tract infections, resulting in an estimated eight million physician visits a year in the United States. It is also a leading cause of nosocomial infections...
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