fission yeast

Summary

Alias: Schizosaccharomyces pombe, Schizosaccharomyces malidevorans, Schizosaccharomyces pombeP

Top Publications

  1. pmc Substitution at position 116 of Schizosaccharomyces pombe calmodulin decreases its stability under nitrogen starvation and results in a sporulation-deficient phenotype
    T Takeda
    Institute of Medical Science, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 86:9737-41. 1989
  2. pmc Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast
    K Shiozaki
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037
    EMBO J 14:492-502. 1995
  3. pmc A fission yeast RCC1-related protein is required for the mitosis to interphase transition
    S Sazer
    Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030
    EMBO J 13:606-15. 1994
  4. pmc Heat shock factor is required for growth at normal temperatures in the fission yeast Schizosaccharomyces pombe
    G J Gallo
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Mol Cell Biol 13:749-61. 1993
  5. pmc Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis
    A Bueno
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037
    Mol Cell Biol 13:2286-97. 1993
  6. pmc A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis
    K Song
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Cell Biol 133:1307-19. 1996
  7. ncbi An actin point-mutation neighboring the 'hydrophobic plug' causes defects in the maintenance of cell polarity and septum organization in the fission yeast Schizosaccharomyces pombe
    J Ishiguro
    Department of Biology, Faculty of Science, Konan University, Kobe, Japan
    FEBS Lett 392:237-41. 1996
  8. ncbi Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast
    Y Watanabe
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Nature 386:187-90. 1997
  9. pmc Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe
    A K Azad
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Mol Biol Cell 8:825-41. 1997
  10. ncbi Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton
    M Arellano
    Instituto de Microbiologia Bioquimica, CSIC Universidad de Salamanca, Spain
    J Cell Sci 110:2547-55. 1997

Research Grants

  1. Studies of the Swi1-Swi3 Replication Fork Protection Complex
    Eishi Noguchi; Fiscal Year: 2012
  2. Identifying Conserved Genetic Networks for Eukaryotic MMR Genes
    Winfried Edelmann; Fiscal Year: 2012
  3. Molecular Architecture of the Regional Kinetochore in Fission Yeast
    Xiangwei He; Fiscal Year: 2012
  4. Regulation of DNA Replication in S. Pombe
    Thomas J Kelly; Fiscal Year: 2010
  5. Matthew J O'Connell; Fiscal Year: 2015
  6. Dannel McCollum; Fiscal Year: 2016
  7. Robert A Martienssen; Fiscal Year: 2015
  8. New determinants of the DNA damage response in the fission yeast S. pombe
    MATTHEW J O'CONNELL; Fiscal Year: 2013
  9. Chk1 signaling in the G2 DNA damage checkpoint
    MATTHEW O CONNELL; Fiscal Year: 2009
  10. Transcription circuitry of the S. pombe cell cycle
    JANET K LEATHERWOOD; Fiscal Year: 2010

Patents

  1. IMPROVING ACTIVITY OF FE-S CLUSTER REQUIRING PROTEINS
  2. PROCESS FOR TRANSFORMANT PRODUCTION, TRANSFORMANT, AND SINGLE POSITION INTRODUCTION TYPE RECOMBINANT VECTOR
  3. CLONING VECTOR, EXPRESSION VECTOR AND PROCESS FOR TRANSFORMANT PRODUCTION
  4. PROCESS FOR PRODUCTION OF 3-HYDROXYPROPIONIC ACID, AND TRANSFORMANT
  5. A MODIFIED MICROORGANISM FOR THE OPTIMIZED PRODUCTION OF 2,4-DIHYDROXYBURYRATE WITH ENHANCED 2,4-DIHYDROXYBUTYRATE EFFLUX
  6. MODIFIED BACTERIAL NANOCELLULOSE AND ITS USES IN CHIP CARDS AND MEDICINE
  7. PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME
  8. COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF VANILLIN OR VANILLIN BETA-D-GLUCOSIDE
  9. TRANSFORMANT AND PROCESS FOR PRODUCTION THEREOF, AND PROCESS FOR PRODUCTION OF LACTIC ACID
  10. PROCESSES AND SYSTEMS FOR THE PRODUCTION OF FERMENTATION PRODUCTS

Detail Information

Publications759 found, 100 shown here

  1. pmc Substitution at position 116 of Schizosaccharomyces pombe calmodulin decreases its stability under nitrogen starvation and results in a sporulation-deficient phenotype
    T Takeda
    Institute of Medical Science, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 86:9737-41. 1989
    We constructed Schizosaccharomyces pombe strains that carry phenylalanine, instead of arginine, as residue 116 of calmodulin by site-directed mutagenesis of the cam1 gene...
  2. pmc Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast
    K Shiozaki
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037
    EMBO J 14:492-502. 1995
    ..we have cloned and analyzed two ptc (phosphatase two C) genes, ptc2+ and ptc3+, from the fission yeast Schizosaccharomyces pombe. Together with the previously identified ptc1+ gene, the enzymes encoded by these genes account for ..
  3. pmc A fission yeast RCC1-related protein is required for the mitosis to interphase transition
    S Sazer
    Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030
    EMBO J 13:606-15. 1994
    ..The gene and suppressor of dcdts are identical to the previously described Schizosaccharomyces pombe genes pim1 (premature initiation of mitosis) and spi1 (suppressor of pim), but the dcdts mutant does not ..
  4. pmc Heat shock factor is required for growth at normal temperatures in the fission yeast Schizosaccharomyces pombe
    G J Gallo
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Mol Cell Biol 13:749-61. 1993
    b>Schizosaccharomyces pombe is becoming an increasingly useful organism for the study of cellular processes, since in certain respects, such as the cell cycle and splicing, it is similar to metazoans...
  5. pmc Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis
    A Bueno
    Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037
    Mol Cell Biol 13:2286-97. 1993
    ..We report the discovery of cig2, a third B-type cyclin gene in Schizosaccharomyces pombe. Disruption of cig2 delays the onset of mitosis, to the degree that a cig2 null allele rescues mitotic ..
  6. pmc A novel suppressor of ras1 in fission yeast, byr4, is a dosage-dependent inhibitor of cytokinesis
    K Song
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Cell Biol 133:1307-19. 1996
    A novel gene, designated byr4, was identified in Schizosaccharomyces pombe that affects the mitotic cell cycle and shows genetic interactions with the ras1 signaling pathways...
  7. ncbi An actin point-mutation neighboring the 'hydrophobic plug' causes defects in the maintenance of cell polarity and septum organization in the fission yeast Schizosaccharomyces pombe
    J Ishiguro
    Department of Biology, Faculty of Science, Konan University, Kobe, Japan
    FEBS Lett 392:237-41. 1996
    The fission yeast cps8 mutation gives rise to abnormally enlarged and dispolarized cells, each of which contains several nuclei with aberrant multisepta...
  8. ncbi Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast
    Y Watanabe
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan
    Nature 386:187-90. 1997
    ..In the fission yeast Schizosaccharomyces pombe, inactivation of the protein kinase Pat1(Ran1) upon nutrient deprivation triggers entry into the meiotic ..
  9. pmc Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe
    A K Azad
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Mol Biol Cell 8:825-41. 1997
    ..We cloned the ptr2+ and ptr3+ genes and found that they encode Schizosaccharomyces pombe homologues of the mammalian RCC1, a guanine nucleotide exchange factor for RAN/TC4, and the ubiquitin-..
  10. ncbi Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton
    M Arellano
    Instituto de Microbiologia Bioquimica, CSIC Universidad de Salamanca, Spain
    J Cell Sci 110:2547-55. 1997
    The Schizosaccharomyces pombe rho1p GTPase directly activates the (1-3) beta-D-glucan synthase and participates in the regulation of cell wall growth and morphogenesis in this fission yeast...
  11. pmc Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1
    W M Toone
    Laboratory of Gene Regulation, Imperial Cancer Research Fund ICRF, London WC2A 3PX
    Genes Dev 12:1453-63. 1998
    The fission yeast Sty1 stress-activated MAP kinase is crucial for the cellular response to a variety of stress conditions...
  12. pmc Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs
    M Gilbreth
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 95:14781-6. 1998
    ..is a putative regulator of Shk1, a p21(Cdc42/Rac)-activated kinase (PAK) homolog in the fission yeast Schizosaccharomyces pombe. skb1 null mutants are viable and competent for mating but less elongate than wild-type S...
  13. pmc Evidence for F-actin-dependent and -independent mechanisms involved in assembly and stability of the medial actomyosin ring in fission yeast
    N I Naqvi
    Cell Division Laboratory, Institute of Molecular Agrobiology, National University of Singapore, 1 Research Link, Singapore 117604, Republic of Singapore
    EMBO J 18:854-62. 1999
    Cell division in a number of eukaryotes, including the fission yeast Schizosaccharomyces pombe, is achieved through a medially placed actomyosin-based contractile ring...
  14. pmc The schizosaccharomyces pombe dim1(+) gene interacts with the anaphase-promoting complex or cyclosome (APC/C) component lid1(+) and is required for APC/C function
    L D Berry
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Biol 19:2535-46. 1999
    The Schizosaccharomyces pombe dim1(+) gene is required for entry into mitosis and for chromosome segregation during mitosis...
  15. pmc Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
    N Kudo
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 96:9112-7. 1999
    ..However, the mechanism by which LMB inhibits CRM1 still remains unclear. CRM1 in a Schizosaccharomyces pombe mutant showing extremely high resistance to LMB had a single amino acid replacement at Cys-529 with Ser...
  16. ncbi Ultrastructure of cell wall of the cps8 actin mutant cell in Schizosaccharomyces pombe
    S A Ishijima
    Department of Chemical and Biological Sciences, Faculty of Science, Japan Women s University, 2 8 1, Mejirodai, Bunkyo ku, Tokyo, Japan
    FEMS Microbiol Lett 180:31-7. 1999
    A Schizosaccharomyces pombe cps8 mutant, of which the gene encodes a mutant actin with an amino acid substitution of Asp for Gly(273) [J. Ishiguro and W. Kobayashi (1996) FEBS Lett...
  17. pmc Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints
    M Shimada
    Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Mol Biol Cell 10:3991-4003. 1999
    We report here the isolation and functional analysis of the rfc3(+) gene of Schizosaccharomyces pombe, which encodes the third subunit of replication factor C (RFC3)...
  18. pmc Isolation and characterization of par1(+) and par2(+): two Schizosaccharomyces pombe genes encoding B' subunits of protein phosphatase 2A
    W Jiang
    Department of Biology, Syracuse University, Syracuse, New York 13244, USA
    Genetics 154:1025-38. 2000
    ..cerevisiae homolog Rts1p. Thus, while Schizosaccharomyces pombe is more similar to higher eukaryotes with respect to its complement of B'-encoding genes, the function ..
  19. pmc Protection of telomeres by the Ku protein in fission yeast
    P Baumann
    Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA
    Mol Biol Cell 11:3265-75. 2000
    b>Schizosaccharomyces pombe cells survive loss of telomeres by a unique pathway of chromosome circularization...
  20. pmc Rdp1, a novel zinc finger protein, regulates the DNA damage response of rhp51(+) from Schizosaccharomyces pombe
    Y S Shim
    School of Biological Sciences, Seoul National University, Seoul 151 742, Republic of Korea
    Mol Cell Biol 20:8958-68. 2000
    The Schizosaccharomyces pombe DNA repair gene rhp51(+) encodes a RecA-like protein with the DNA-dependent ATPase activity required for homologous recombination...
  21. pmc Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex
    R T Janoo
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Genetics 157:1205-15. 2001
    The Schizosaccharomyces pombe fbp1 gene, which encodes fructose-1,6-bis-phosphatase, is transcriptionally repressed by glucose through the activation of the cAMP-dependent protein kinase A (PKA) and transcriptionally activated by glucose ..
  22. pmc The role of Plo1 kinase in mitotic commitment and septation in Schizosaccharomyces pombe
    K Tanaka
    School of Biological Sciences, 2 205 Stopford Building, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    EMBO J 20:1259-70. 2001
    ..The ability of plo1(+) overexpression to induce septation was severely compromised by SIN inactivation. We propose that Plo1 acts before the SIN to control septation...
  23. pmc Gain- and loss-of-function of Rhp51, a Rad51 homolog in fission yeast, reveals dissimilarities in chromosome integrity
    W J Kim
    School of Biological Sciences, Seoul National University, Kwanak Ku, Shilim Dong, Seoul 151 742, Republic of Korea
    Nucleic Acids Res 29:1724-32. 2001
    ..Rhp51, a Rad51 homolog in Schizosaccharomyces pombe, has a highly conserved ATP-binding motif...
  24. pmc Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint
    M A Garcia
    Laboratory of Cell Regulation, Imperial Cancer Research Fund, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 20:3389-401. 2001
    The TOG/XMAP215-related proteins play a role in microtubule dynamics at its plus end. Fission yeast Alp14, a newly identified TOG/XMAP215 family protein, is essential for proper chromosome segregation in concert with a second homologue ..
  25. ncbi The S. pombe aurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation
    J Petersen
    School of Biological Sciences, 2 205 Stopford Building, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 114:4371-84. 2001
    ..As in many other systems mitotic fission yeast cells exhibit a much greater degree of phosphorylation of serine 10 of histone H3 than interphase cells...
  26. pmc Fission yeast F-box protein Pof3 is required for genome integrity and telomere function
    Satoshi Katayama
    Laboratory of Cell Regulation, Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom
    Mol Biol Cell 13:211-24. 2002
    ..We have identified a fission yeast gene encoding a novel F-box protein Pof3, which contains, in addition to the F-box, a tetratricopeptide repeat ..
  27. ncbi The kic1 kinase of schizosaccharomyces pombe is a CLK/STY orthologue that regulates cell-cell separation
    Zhaohua Tang
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Exp Cell Res 283:101-15. 2003
    ..Here we show that a functionally conserved CLK/STY kinase exists in Schizosaccharomyces pombe, and this orthologue, called Kic1, regulates the cell surface and septum formation as well as a late ..
  28. pmc Condensin but not cohesin SMC heterodimer induces DNA reannealing through protein-protein assembly
    Akiko Sakai
    Department of Biophysics, Graduate School of Science, Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
    EMBO J 22:2764-75. 2003
    ..In this study, DNA interaction with cohesin and condensin complexes purified from fission yeast was investigated...
  29. pmc The PCH family protein, Cdc15p, recruits two F-actin nucleation pathways to coordinate cytokinetic actin ring formation in Schizosaccharomyces pombe
    Robert H Carnahan
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 162:851-62. 2003
    Cytokinetic actin ring (CAR) formation in Schizosaccharomyces pombe requires two independent actin nucleation pathways, one dependent on the Arp2/3 complex and another involving the formin Cdc12p. Here we investigate the role of the S...
  30. pmc Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1
    Eishi Noguchi
    Department of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell Biol 23:7861-74. 2003
    ..Here we report studies of fission yeast Swi1, a Tof1-related protein required for a programmed fork-pausing event necessary for mating type switching...
  31. ncbi Role of guanine nucleotide exchange factors for Rho family GTPases in the regulation of cell morphology and actin cytoskeleton in fission yeast
    Nobuhiko Iwaki
    Graduate School of Science and Technology, Kobe University, 1 1 Rokkodai cho Nada Kobe 657 8501, Japan
    Biochem Biophys Res Commun 312:414-20. 2003
    ..In fission yeast Schizosaccharomyces pombe, six members of the Rho small GTPase family were identified and reported to be involved in cell ..
  32. pmc The involvement of Srs2 in post-replication repair and homologous recombination in fission yeast
    Claudette L Doe
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nucleic Acids Res 32:1480-91. 2004
    ..unlike in Saccharomyces cerevisiae, Srs2 is not required for channelling lesions to the PRR pathway in Schizosaccharomyces pombe. In addition to acting as an antirecombinase, we also show that Srs2 can aid the recombinational repair ..
  33. ncbi Identification of thermostable glyoxalase I in the fission yeast Schizosaccharomyces pombe
    Yoshifumi Takatsume
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    Arch Microbiol 181:371-7. 2004
    ..Here, the structural gene for glyoxalase I ( glo1(+)) from the fission yeast Schizosaccharomyces pombe was identified...
  34. ncbi The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules
    Karl Emanuel Busch
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Biol 14:548-59. 2004
    ..It is unknown whether these proteins operate independently or whether their actions are coordinated. In fission yeast the CLIP-170 homolog tip1p is required for targeting of microtubules to cell ends, whereas the role of the EB1 ..
  35. pmc Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts
    Jennifer A Young
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genetics 167:593-605. 2004
    ..Meiotic DNA breakage in Schizosaccharomyces pombe did not require Rad50 or Rad32, although the homologs Rad50 and Mre11 are required in Saccharomyces ..
  36. pmc UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II
    Matthew Lord
    Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    J Cell Biol 167:315-25. 2004
    We purified native Myo2p/Cdc4p/Rlc1p (Myo2), the myosin-II motor required for cytokinesis by Schizosaccharomyces pombe. The Myo2p heavy chain associates with two light chains, Cdc4p and Rlc1p...
  37. pmc Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast
    David R Kovar
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Mol Biol Cell 16:2313-24. 2005
    b>Fission yeast capping protein SpCP is a heterodimer of two subunits (Acp1p and Acp2p) that binds actin filament barbed ends...
  38. pmc Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast
    Sabina Zimmerman
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Biol Cell 16:2719-33. 2005
    ..Our findings show that mto1p and gamma-TuCs affect multiple properties of MTs including nucleation, nuclear attachment, plus-end catastrophe, and minus-end shrinkage...
  39. ncbi Protein O-mannosylation is crucial for cell wall integrity, septation and viability in fission yeast
    Tobias Willer
    Heidelberg Institute of Plant Sciences, Department V Cell Chemistry, University of Heidelberg, Im Neuenheimer Feld 360, D 69120 Heidelberg, Germany
    Mol Microbiol 57:156-70. 2005
    ..In this study we identified and characterized the PMT family of the archaeascomycete Schizosaccharomyces pombe. Unlike Saccharomyces cerevisiae where the PMT family is highly redundant, in S...
  40. ncbi Cell wall remodeling at the fission yeast cell division site requires the Rho-GEF Rgf3p
    Jennifer L Morrell-Falvey
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cell Sci 118:5563-73. 2005
    Cytokinesis in Schizosaccharomyces pombe is accompanied by several stages of cell wall remodeling at the division site...
  41. pmc Fission yeast Rho5p GTPase is a functional paralogue of Rho1p that plays a role in survival of spores and stationary-phase cells
    Sergio A Rincon
    Instituto Microbiología Bioquímica, CSIC Universidad de Salamanca, Campus Unamuno, 37007 Salamanca, Spain
    Eukaryot Cell 5:435-46. 2006
    ..b>Schizosaccharomyces pombe Rho1p is essential, directly activates the (1,3)-beta-d-glucan synthase, and participates in regulation ..
  42. pmc Fta2, an essential fission yeast kinetochore component, interacts closely with the conserved Mal2 protein
    Anne Kerres
    Lehrstuhl für Funktionelle Genomforschung der Mikroorganismen, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mol Biol Cell 17:4167-78. 2006
    The fission yeast multiprotein-component Sim4 complex plays a fundamental role in the assembly of a functional kinetochore...
  43. ncbi The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits
    Jan Palecek
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    J Biol Chem 281:36952-9. 2006
    ..We further show that Nse3, as well as Nse5 and Nse6, also bridge the heads of Smc5 and -6. The Nse1-Nse3-Nse4 and Nse5-Nse6 subcomplexes bind to the Smc5-Smc6 heads domain at different sites...
  44. ncbi Fission yeast Tor2 promotes cell growth and represses cell differentiation
    Beatriz Alvarez
    Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    J Cell Sci 119:4475-85. 2006
    The fission yeast Schizosaccharomyces pombe is an excellent model system in which to study the coordination of cell growth and cell differentiation...
  45. ncbi A method for Pmo25-associated kinase assay in fission yeast: the activity is dependent on two gC kinases Nak1 and Sid1
    Kazunori Kume
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi Hiroshima, Japan
    Biosci Biotechnol Biochem 71:615-7. 2007
    In fission yeast, the conserved proteins, MO25/Pmo25, GC kinase/Nak1, Furry/Mor2, NDR kinase/Orb6, and Mob2, constitute the morphogenesis Orb6 network (MOR)...
  46. ncbi S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription
    Fei Lan
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 26:89-101. 2007
    ....
  47. ncbi Dynein participates in chromosome segregation in fission yeast
    Thibault Courtheoux
    LBCMCP CNRS UMR5088, Institut d Exploration, Fonctionelle des Génomes IFR109, Université Paul, Sabatier, 118 route de Narbonne, 31062 Toulouse, France
    Biol Cell 99:627-37. 2007
    ..At the metaphase-anaphase transition, cohesion between sister chromatids is removed, and each sister chromatid is pulled to opposite poles of the cell by microtubule-dependent forces...
  48. ncbi The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi
    Erwan Lejeune
    European Molecular Biology Laboratory, Gene Expression Unit, Structural and Computational Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Biol 17:1219-24. 2007
    ..In several organisms, including the fission yeast, Schizosaccharomyces pombe, the RNAi pathway contributes to the formation of silent chromatin in pericentromeric regions...
  49. ncbi Six new amino acid-auxotrophic markers for targeted gene integration and disruption in fission yeast
    Yan Ma
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    Curr Genet 52:97-105. 2007
    Fission yeast Schizosaccharomyces pombe is amenable to genetics and is an excellent model system for studying eukaryotic cell biology...
  50. pmc SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast
    Alfica Sehgal
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, Unites States of America
    PLoS Genet 3:e131. 2007
    ..Here, we report that low oxygen activates the fission yeast Tf2 family of retrotransposons...
  51. pmc Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast
    Wanzhong Ge
    Cell Division Laboratory, Temasek Life Sciences Laboratory and the Department of Biological Sciences, National University of Singapore, Singapore
    Mol Biol Cell 19:1680-92. 2008
    ..Here, we identify and characterize a paxillin-related protein Pxl1p in the fission yeast Schizosaccharomyces pombe. Pxl1p is a component of the fission yeast actomyosin ring, a structure that is essential for ..
  52. doi A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast
    Yuu Kimata
    Cell Cycle Control Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Dev Cell 14:446-54. 2008
    ..Here we show that fission yeast Mes1 is a substrate of the APC/C as well as an inhibitor, allowing autoregulation of the APC/C in meiosis...
  53. doi Cloning and overexpression of a maltase gene from Schizosaccharomyces pombe in Escherichia coli and characterization of the recombinant maltase
    Zhenming Chi
    UNESCO Chinese Center of Marine Biotechnology, Ocean University of China, Yushan Road, No 5, Qingdao, Shandong 266003, China
    Mycol Res 112:983-9. 2008
    The Schizosaccharomyces pombe maltase structural gene (SPMAL1(+)) was amplified from genomic DNA of S. pombe by PCR. An open reading frame of 1740bp, encoding a putative 579 amino-acid protein with a calculated molecular mass of 67...
  54. pmc Tdp1 protects against oxidative DNA damage in non-dividing fission yeast
    Samia Ben Hassine
    Dynamic of the Genome Unit, Genomes and Genetic Department, Institut Pasteur, URA2171, Paris, France
    EMBO J 28:632-40. 2009
    ..Here, we report that in the yeast Schizosaccharomyces pombe, tdp1 mutant cells progressively accumulate DNA damage and rapidly lose viability in a physiological G0/..
  55. pmc Cofilin dissociates Arp2/3 complex and branches from actin filaments
    Chikio Chan
    Department of Molecular Cellular, Yale University, PO Box 208103, New Haven, CT 06520 8103, USA
    Curr Biol 19:537-45. 2009
    ..This study investigates how cofilin and Arp2/3 complex, two main players in the dendritic nucleation model, interact to produce sharp spatial transitions between densely branched filaments and long, unbranched filaments...
  56. pmc Regulation of cytokinesis by the formin cdc12p
    Ann Yonetani
    Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Curr Biol 20:561-6. 2010
    ..In the fission yeast Schizosaccharomyces pombe, contractile ring assembly initiates at the onset of mitosis, and ring contraction occurs concomitant ..
  57. pmc A novel role of Dma1 in regulating forespore membrane assembly and sporulation in fission yeast
    Wen zhu Li
    School of Life Sciences, Xiamen University, Xiamen 361005, Fujian, China
    Mol Biol Cell 21:4349-60. 2010
    In fission yeast Schizosaccharomyces pombe, a diploid mother cell differentiates into an ascus containing four haploid ascospores following meiotic nuclear divisions, through a process called sporulation...
  58. pmc Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks
    Oliver Limbo
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Cell Biol 31:573-83. 2011
    Rad3, the Schizosaccharomyces pombe ortholog of human ATR and Saccharomyces cerevisiae Mec1, activates the checkpoint kinase Chk1 in response to DNA double-strand breaks (DSBs)...
  59. pmc Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin
    Francisca E Reyes-Turcu
    Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Struct Mol Biol 18:1132-8. 2011
    Heterochromatin assembly at Schizosaccharomyces pombe centromeres involves a self-reinforcing loop mechanism wherein chromatin-bound RNAi factors facilitate targeting of Clr4-Rik1 methyltransferase...
  60. pmc A novel RNAi protein, Dsh1, assembles RNAi machinery on chromatin to amplify heterochromatic siRNA
    Kei Kawakami
    Laboratory of Bioorganic Chemistry, Department of Chemistry, Hokkaido University, Sapporo, Japan
    Genes Dev 26:1811-24. 2012
    In fission yeast, siRNA is generated from pericentromeric noncoding RNA by the RNAi machinery. siRNA synthesis and heterochromatin formation are interdependent, forming a self-reinforcing loop on chromatin...
  61. pmc The fission yeast synaptobrevin ortholog Syb1 plays an important role in forespore membrane formation and spore maturation
    Tomomi Yamaoka
    Department of Biology, Graduate School of Science, Osaka City University, Sumiyoshi ku, Osaka, Japan
    Eukaryot Cell 12:1162-70. 2013
    ..Previous studies have revealed that, similar to synaptobrevin in other organisms, the fission yeast synaptobrevin ortholog Syb1 associates with post-Golgi secretory vesicles and is essential for cytokinesis and ..
  62. pmc Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation
    Fan Zheng
    Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong, China HKU Shenzhen Institute of Research and Innovation, University of Hong Kong, Shenzhen, China
    Mol Biol Cell 25:2750-60. 2014
    ..Here we show that the fission yeast Schizosaccharomyces pombe TACC orthologue alp7p is recruited to the SPB by csi1p...
  63. pmc The Schizosaccharomyces pombe homolog of Saccharomyces cerevisiae HAP2 reveals selective and stringent conservation of the small essential core protein domain
    J T Olesen
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Mol Cell Biol 11:611-9. 1991
    The fission yeast Schizosaccharomyces pombe is immensely diverged from budding yeast (Saccharomyces cerevisiae) on an evolutionary time scale. We have used a fission yeast library to clone a homolog of S...
  64. pmc Effect of human immunodeficiency virus type 1 protein R (vpr) gene expression on basic cellular function of fission yeast Schizosaccharomyces pombe
    Y Zhao
    Section of Pediatric and Maternal Human Immunodeficiency Virus Infections, Children s Memorial Hospital, Illinois, USA
    J Virol 70:5821-6. 1996
    ..In this study, we used the fission yeast Schizosaccharomyces pombe as a model system to investigate the cellular effects of HIV-1 vpr gene expression...
  65. ncbi Type II myosin involved in cytokinesis in the fission yeast, Schizosaccharomyces pombe
    K M May
    Department of Biology, University College London, United Kingdom
    Cell Motil Cytoskeleton 38:385-96. 1997
    We have cloned an unique gene encoding the heavy chain of a type II myosin in the fission yeast, Schizosaccharomyces pombe. The myo2+ gene encodes a protein of 1526 amino acids with a predicted molecular weight of 177 kDa and containing ..
  66. ncbi Effects of the myosin inhibitor 2,3-butanedione monoxime on the physiology of fission yeast
    G Steinberg
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, USA
    Eur J Cell Biol 77:284-93. 1998
    ..Here we describe the influence of BDM on growth and division of the fission yeast Schizosaccharomyces pombe. At concentrations from 1-30 mM, BDM gradually inhibited formation and growth of S...
  67. ncbi Identification of sds21 in fission yeast in an inhibitor-resistant high molecular mass protein phosphatase-1 complex
    J F Dawson
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Biochem Cell Biol 77:551-8. 1999
    While characterizing the type-1 protein phosphatases sds21 and dis2 in fission yeast (Schizosaccharomyces pombe) a novel high molecular mass protein was identified with serine/threonine phosphatase activity (referred to as PP-R) that was ..
  68. pmc Genetic studies with the fission yeast Schizosaccharomyces pombe suggest involvement of wee1, ppa2, and rad24 in induction of cell cycle arrest by human immunodeficiency virus type 1 Vpr
    M Masuda
    Department of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    J Virol 74:2636-46. 2000
    ..Recently, it has been shown that Vpr also causes cell cycle arrest in the fission yeast Schizosaccharomyces pombe, which shares the cell cycle regulatory mechanisms with higher eukaryotes including humans...
  69. pmc Genome-wide studies of histone demethylation catalysed by the fission yeast homologues of mammalian LSD1
    Michael Opel
    Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 2:e386. 2007
    ..to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1...
  70. ncbi Protective role and regulation of Rad9 from the fission yeast Schizosaccharomyces pombe
    Min Hee Kang
    Division of Life Sciences and Research Institute of Life Sciences, College of Natural Sciences, Kangwon National University, Chuncheon, Korea
    FEMS Microbiol Lett 275:270-7. 2007
    To assess novel cellular roles and regulation of Rad9 in the fission yeast Schizosaccharomyces pombe, the full-length rad9 gene was cloned into the shuttle vector pRS316, generating pYFRad9...
  71. doi Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe
    Mai Nakase
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6 10 1, Fukuoka 812 8581, Japan
    J Cell Sci 123:1578-87. 2010
    ..of Ipt1p, the inositolphosphotransferase that synthesizes M(IP)(2)C from MIPC, has been found in the Schizosaccharomyces pombe genome...
  72. doi Protective roles and Pap1-dependent regulation of the Schizosaccharomyces pombe spy1 gene under nitrosative and nutritional stresses
    Min Hee Kang
    Division of Life Sciences and Research Institute of Life Sciences, College of Natural Sciences, Kangwon National University, 192 1 Hyoja 2 Dong, Chuncheon, 200 701, Korea
    Mol Biol Rep 38:1129-36. 2011
    ..roles and regulation of Spy1, a histidine-containing phosphotransfer (HPt) protein, in the fission yeast Schizosaccharomyces pombe. The structural gene encoding Spy1 was cloned into the shuttle vector pRS316 to generate the recombinant ..
  73. ncbi Molecular mechanism of myosin-II assembly at the division site in Schizosaccharomyces pombe
    F Motegi
    Division of Biology, Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan
    J Cell Sci 113:1813-25. 2000
    b>Schizosaccharomyces pombe cells divide by virtue of the F-actin-based contractile ring (F-actin ring). Two myosin-II heavy chains, Myo2 and Myp2/Myo3, have been localized to the F-actin ring...
  74. pmc Isolation, characterization, and molecular cloning of a protein (Abp2) that binds to a Schizosaccharomyces pombe origin of replication (ars3002)
    J P Sanchez
    Graduate Program in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 18:1670-81. 1998
    ..the most active replication origin within a cluster of three closely spaced origins on chromosome III of Schizosaccharomyces pombe. A 361-bp portion of ars3002 containing detectable ARS activity includes multiple near matches to the S...
  75. pmc The Schizosaccharomyces pombe rad11+ gene encodes the large subunit of replication protein A
    A E Parker
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 17:2381-90. 1997
    ..We report here the cloning of the largest subunit of RPA (rpa1+) from the fission yeast Schizosaccharomyces pombe. The rpa1+ gene is essential for viability and is expressed specifically at S phase of the cell cycle...
  76. ncbi Structural modification of spindle pole bodies during meiosis II is essential for the normal formation of ascospores in Schizosaccharomyces pombe: ultrastructural analysis of spo mutants
    A Hirata
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Yeast 10:173-83. 1994
    ..steps defined by sporulation (spo) genes during the formation of ascospores in the fission yeast Schizosaccharomyces pombe, we performed an electron microscopic study of the ultrastructure of the spindle pole body (SPB) and of ..
  77. pmc A temperature-sensitive mutation of the Schizosaccharomyces pombe gene nuc2+ that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase
    T Hirano
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    J Cell Biol 106:1171-83. 1988
    A temperature-sensitive mutant nuc2-663 of the fission yeast Schizosaccharomyces pombe specifically blocks mitotic spindle elongation at restrictive temperature so that nuclei in arrested cells contain a short uniform spindle (..
  78. pmc The Srp54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe
    S M Althoff
    Department of Biochemistry, University of Illinois, Urbana 61801
    Mol Cell Biol 14:7839-54. 1994
    ..Here we report the results of a series of experiments to define the function of the Schizosaccharomyces pombe homolog of the 54-kDa subunit of mammalian SRP...
  79. pmc Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p
    D Selinger
    Department of Biochemistry, University of Illinois at Urbana Champaign 61801
    Nucleic Acids Res 22:2557-67. 1994
    ..Earlier work identified a Schizosaccharomyces pombe homolog of human SRP RNA and showed that it is a component of a particle similar in size and biochemical ..
  80. pmc The Rpb4 subunit of fission yeast Schizosaccharomyces pombe RNA polymerase II is essential for cell viability and similar in structure to the corresponding subunits of higher eukaryotes
    H Sakurai
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Mol Cell Biol 19:7511-8. 1999
    ..the gene and the cDNA encoding the Rpb4 subunit of RNA polymerase II were cloned from the fission yeast Schizosaccharomyces pombe. The cDNA sequence indicates that Rpb4 consists of 135 amino acid residues with a molecular weight of 15,..
  81. pmc Multiple hexose transporters of Schizosaccharomyces pombe
    S Heiland
    Botanisches Institut, Universitat Bonn, 53115 Bonn, Germany
    J Bacteriol 182:2153-62. 2000
    We have identified a family of six hexose transporter genes (Ght1 to Ght6) in the fission yeast Schizosaccharomyces pombe. Sequence homology to Saccharomyces cerevisiae and mammalian hexose transporters (Hxtp and GLUTp, respectively) and ..
  82. ncbi His-to-Asp phosphorelay circuitry for regulation of sexual development in Schizosaccharomyces pombe
    Norihito Nakamichi
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Biosci Biotechnol Biochem 66:2663-72. 2002
    The fission yeast Schizosaccharomyces pombe has three histidine kinases (Phk1/Mak2, Phk2/Mak3, and Phk3/Mak1), and two response regulators (Mcs4 and Prr1). The results of recent extensive studies on the S...
  83. ncbi The novel Rho GTPase-activating protein family protein, Rga8, provides a potential link between Cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe
    Peirong Yang
    Department of Molecular Genetics and Program in Genes and Development, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 278:48821-30. 2003
    The PAK family kinase, Shk1, is an essential regulator of polarized growth in the fission yeast, Schizosaccharomyces pombe. Here we describe the characterization of a novel member of the RhoGAP family, Rga8, identified from a two-hybrid ..
  84. ncbi The gene encoding gamma-glutamyl transpeptidase II in the fission yeast is regulated by oxidative and metabolic stress
    Hyun Jung Kang
    Division of Life Sciences, College of Natural Sciences, Kangwon National University, Chuncheon, Korea
    J Biochem Mol Biol 38:609-18. 2005
    ..A second gene (GGTII) encoding GGT was previously isolated and characterized from the fission yeast Schizosaccharomyces pombe. In the present work, the GGTII-lacZ fusion gene was constructed and used to study the transcriptional ..
  85. pmc A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif
    F Melchior
    Department of Biochemistry, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany
    Mol Biol Cell 4:569-81. 1993
    ..We describe the purification of a 44-kDa protein from the evolutionary distant fission yeast Schizosaccharomyces pombe and the cloning and sequence analysis of the corresponding gene...
  86. ncbi Differences in in vivo acceptor specificity of two galactosyltransferases, the gmh3+ and gma12+ gene products from Schizosaccharomyces pombe
    T Yoko-o
    National Institute of Bioscience and Human Technology, Tsukuba, Ibaraki, Japan
    Eur J Biochem 257:630-7. 1998
    In the fission yeast Schizosaccharomyces pombe, gmh1+, gmh2+ and gmh3+ genes encode alpha-1,2-galactosyltransferase homologues...
  87. pmc H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases
    Klavs R Hansen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 7:e1001268. 2011
    ..conserved and are found in both multicellular eukaryotes and single-cell model organisms such as fission yeast. In spite of numerous studies, the relative contributions of the various heterochromatic histone marks to the ..
  88. ncbi Evidence for cell cycle-specific, spindle pole body-mediated, nuclear positioning in the fission yeast Schizosaccharomyces pombe
    I Hagan
    School of Biological Sciences, University of Manchester, UK
    J Cell Sci 110:1851-66. 1997
    Specific changes in spatial order occur during cell cycle progression in fission yeast. Growth of the rod-shaped cells is highly regulated and undergoes a cell cycle and size-regulated switch from monopolar to bipolar tip extension...
  89. ncbi Peptide elongation factor 1 from yeasts: purification and biochemical characterization of peptide elongation factors 1 alpha and 1 beta (gamma) from Saccharomyces carlsbergensis and Schizosaccharomyces pombe
    M Miyazaki
    Department of Molecular Biology, School of Science, Nagoya University, Aichi
    J Biochem 103:508-21. 1988
    ..carls.) and Schizosaccharomyces pombe (S. pombe)...
  90. pmc The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe
    Diego Miranda-Saavedra
    College of Life Sciences, University of Dundee, Dow St, Dundee DD1 5EH, Scotland, UK
    BMC Genomics 8:309. 2007
    ..cuniculi genomic database aimed at identifying and classifying all protein kinases of this organism with reference to the kinomes of two highly-divergent yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe.
  91. ncbi [RNAi and the formation of heterochromatin in Schizosaccharomyces pombe.]
    Sophie Barral
    Institut National de la Sante et de la Recherche Medicale, U823, Institut Albert Bonniot Université Joseph Fourier, F 38700 Grenoble, France
    J Soc Biol 201:401-10. 2007
    In the fission yeast Schizosaccharomyces pombe, formation of pericentromeric heterochromatin involves RNA interference (RNAi)...
  92. ncbi Sensitivity to cisplatin and platinum-containing compounds of Schizosaccharomyces pombe rad mutants
    P Perego
    Department of Experimental Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    Mol Pharmacol 54:213-9. 1998
    ..sensitivity to platinum-containing compounds was studied using a panel of 23 strains of the yeast Schizosaccharomyces pombe. The radiation-hypersensitive mutants all had the same genetic background and most of them contained ..
  93. pmc Involvement of the spliceosomal U4 small nuclear RNA in heterochromatic gene silencing at fission yeast centromeres
    Madoka Chinen
    Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kumamoto 860 8555, Japan
    J Biol Chem 285:5630-8. 2010
    ..isolated in a screen for defective pre-mRNA splicing at a nonpermissive temperature in fission yeast Schizosaccharomyces pombe. We cloned the prp13(+) gene and found that it encodes U4 small nuclear RNA (snRNA) involved in the ..
  94. pmc A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe
    Alexandra M Locovei
    Department of Molecular and Cellular Phamacology, University of Miami School of Medicine PO Box 016189, Miami, FL 33140, USA
    Cell Div 5:20. 2010
    In fission yeast the intra-S phase and DNA damage checkpoints are activated in response to inhibition of DNA replication or DNA damage, respectively...
  95. pmc Cell cycle-dependent roles for the FCH-domain protein Cdc15p in formation of the actomyosin ring in Schizosaccharomyces pombe
    Volker Wachtler
    Cell Division Laboratory, Temasek Life Sciences Laboratory, Singapore 117604, Singapore
    Mol Biol Cell 17:3254-66. 2006
    Cell division in the fission yeast Schizosaccharomyces pombe requires the formation and constriction of an actomyosin ring at the division site...
  96. pmc Regulation of CDP-diacylglycerol synthesis and utilization by inositol and choline in Schizosaccharomyces pombe
    P M Gaynor
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor 48109 0606
    J Bacteriol 174:5711-8. 1992
    ..PI) synthase, and phosphatidylserine (PS) synthase in cell extracts of the fission yeast Schizosaccharomyces pombe. In complete synthetic medium containing inositol, maximal expression of CDP-DG synthase, PGP synthase, ..
  97. ncbi Molecular assembly of RNA polymerase II from the fission yeast Schizosaccharomyces pombe: subunit-subunit contact network involving Rpb5
    T Miyao
    National Institute of Genetics, Department of Molecular Genetics, Mishima, Shizuoka, Japan
    Genes Cells 1:843-54. 1996
    ..Toward this ultimate goal, we analysed the topological arrangement of the putative subunits. Here we report a subunit-subunit contact network involving subunit 5 of the fission yeast Schizosaccharomyces pombe RNA polymerase II.
  98. ncbi The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe
    H Maekawa
    Department of Biology, Faculty of Science, Osaka City University, Japan
    Mol Gen Genet 244:456-64. 1994
    When the fission yeast Schizosaccharomyces pombe is starved for nitrogen, the cells are arrested in the G1 phase, enter the G0 phase and initiate sexual development...
  99. ncbi Characterization, expression and regulation of a third gene encoding glutathione S-transferase from the fission yeast
    Youn Hee Shin
    Division of Life Sciences, College of Natural Sciences, Kangwon National University, Chunchon 200 701, South Korea
    Biochim Biophys Acta 1577:164-70. 2002
    A third gene encoding glutathione S-transferase (GSTIII) was cloned from the fission yeast Schizosaccharomyces pombe. The nucleotide sequence determined was found to contain 2110 base pairs including an open reading frame of 242 amino ..
  100. ncbi Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1
    Matthias Bureik
    Universitat des Saarlandes, FR 8 8 Biochemie, Postfach 151150, D 66041 Saarbrucken, Germany
    Biochemistry 41:2311-21. 2002
    ..of these enzymes, we expressed the human CYP11B2 (aldosterone synthase, P450(aldo)) in fission yeast Schizosaccharomyces pombe. Analysis of the subcellular localization of the P450 enzyme by Western blot analysis, fluorescence ..
  101. pmc The amino acid sequence of the small monomeric phosphoglycerate mutase from the fission yeast Schizosaccharomyces pombe
    J Nairn
    Department of Biological and Molecular Sciences, University of Stirling, U K
    Biochem J 297:603-8. 1994
    ..monomeric 2,3-bisphosphoglycerate (BPG)-dependent phosphoglycerate mutase (PGAM) from the fission yeast Schizosaccharomyces pombe has been determined. Amino acid sequencing of proteolytic fragments of the enzyme showed the S...

Research Grants73

  1. Studies of the Swi1-Swi3 Replication Fork Protection Complex
    Eishi Noguchi; Fiscal Year: 2012
    ..of the DNA replication checkpoint and stabilization of stalled replication forks in the fission yeast Schizosaccharomyces pombe. The Swi1-Swi3 complex is evolutionally conserved and homologous to Tof1-Csm3 in budding yeast ..
  2. Identifying Conserved Genetic Networks for Eukaryotic MMR Genes
    Winfried Edelmann; Fiscal Year: 2012
    ..identify the core genetic networks related to MMR in two highly divergent model eukaryotes, the fission (Schizosaccharomyces pombe;Sp) and budding (Saccharomyces cerevisiae;Sc) yeasts...
  3. Molecular Architecture of the Regional Kinetochore in Fission Yeast
    Xiangwei He; Fiscal Year: 2012
    ..the kinetochore and to understand the mechanisms by which kinetochores mediate chromosome segregation in the fission yeast S.pombe...
  4. Regulation of DNA Replication in S. Pombe
    Thomas J Kelly; Fiscal Year: 2010
    ..characterize proteins involved in initiation of DMA replication and its control in the model organism Schizosaccharomyces pombe. Our major objectives are to characterize the assembly and activation of initiation complexes, to define ..
  5. Matthew J O'Connell; Fiscal Year: 2015
    ..is primarily historic, as it was first defined by rad18-X (now smc6-X), a radiation sensitive mutant in Schizosaccharomyces pombe. Moreover, the same collection of rad mutants includes the cohesin gene rad21...
  6. Dannel McCollum; Fiscal Year: 2016
    ..Eukaryotic cells possess two conserved Ndr kinase pathways, called the SIN and MOR in fission yeast (S. pombe) or the Hippo/Lats and Ndr1/2 pathways in mammals...
  7. Robert A Martienssen; Fiscal Year: 2015
    ..We have found that the epigenetic inheritance of heterochromatin in fission yeast requires RNA interference (RNAi) to guide histone modification, which occurs during the DNA replication phase ..
  8. New determinants of the DNA damage response in the fission yeast S. pombe
    MATTHEW J O'CONNELL; Fiscal Year: 2013
    ..The experiments are performed in the fission yeast Schizosaccharomyces pombe, a model system that has provided a paradigm of cell cycle and checkpoint control. S...
  9. Chk1 signaling in the G2 DNA damage checkpoint
    MATTHEW O CONNELL; Fiscal Year: 2009
    ..Our studies therefore utilize the fission yeast Schizosaccharomyces pombe as model for gene and pathway discovery, and with the high conservation, these data inform studies in ..
  10. Transcription circuitry of the S. pombe cell cycle
    JANET K LEATHERWOOD; Fiscal Year: 2010
    Microarrays were used to measure gene expression through the cell cycle of S. pombe (fission yeast), and 750 cell cycle regulated genes were identified. These were placed into clusters...
  11. FASEB SRC on Yeast Chromosome Structure, Replication and Segregation
    Scott Keeney; Fiscal Year: 2012
    ..chromosome biology and cell biology in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe, using a range of experimental approaches including genetics, cytology, biochemistry, molecular biology, ..
  12. Hiten D Madhani; Fiscal Year: 2016
    ..has been instrumental in dissecting the biology of model fungi such as Saccharomyces cerevisiae and Schizosaccharomyces pombe, the generation of analogous complete gene deletion collections in pathogenic fungi would create ..
  13. Kurt W Runge; Fiscal Year: 2014
    ..To identify additional longevity pathways, we developed a new aging assay in Schizosaccharomyces pombe that recapitulates the evolutionarily conserved properties of lifespan extension by caloric restriction ..
  14. David Gresham; Fiscal Year: 2016
    ..We will use the single-celled eukaryotic microbes, Saccharomyces cerevisiae (budding yeast) and Schizosaccharomyces pombe (fission yeast) to identify the conserved networks that regulate cell quiescence...
  15. Centromere structure and isochromosome formation in Candida albicans
    Laura S Burrack; Fiscal Year: 2010
    ..Predicted homologs of DASH complex members in S. cerevisiae and Schizosaccharomyces pombe attach centromeres to microtubules...
  16. Antifungal drug target prioritization using Cryptococcus neoformans
    Alexander Idnurm; Fiscal Year: 2013
    ..from commonly studied pathogenic or model species like Candida albicans, Saccharomyces cerevisiae or Schizosaccharomyces pombe (in phylum Ascomycota), and thus discoveries made in this organism are expected to extend across all ..
  17. Trey Ideker; Fiscal Year: 2015
    ..eukaryotes, our studies are focused on the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe-impacting our basic knowledge of the DNA damage response while keeping within species for which systems ..
  18. FACTORS CONTROLLING TRANSCRIPTION AND CHROMATIN IN YEAST
    FRED M WINSTON; Fiscal Year: 2013
    ..aspects of transcription and chromatin regulation, using the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Our studies will focus on several areas that are conserved with higher eukaryotes...
  19. Haiyuan Yu; Fiscal Year: 2016
    ..pombe. Next to budding yeast, the fission yeast S...
  20. ATF2 in DNA damage response.
    ZE apos EV A RONAI; Fiscal Year: 2010
    ..characterize the role of ATF2 in histone acetylation and the induction of ATM in response to DSB;(2) Utilize fission yeast as a model to genetically dissect ATF2 homolog (Atf21, Pcr1) functions in DNA damage responses...
  21. Hiten D Madhani; Fiscal Year: 2016
    ..both H3K9 methylation and RNAi systems) to studies of silencing in the highly tractable fission yeast Schizosaccharomyces pombe. In this proposal, we seek to capitalize on a series of preliminary investigations in fission yeast ..
  22. MECHANISM OF TERMINATION OF DNA REPLICATION
    Deepak Bastia; Fiscal Year: 2010
    ..cerevisiae and the distantly related fission yeast Schizosaccharomyces pombe by using a combination of yeast genetics, in vivo and in vitro biochemistry and to start work towards ..
  23. The MRAD9 Radioresistance Gene
    Howard B Lieberman; Fiscal Year: 2013
    ..Previous efforts of ours have focused on fission yeast S...
  24. Genetic Analysis of MSM Protein Function in S. Pombe
    Susan L Forsburg; Fiscal Year: 2012
    ..This proposal uses a tractable model system, the fission yeast S. pombe, to investigate the contributions of MCM proteins to chromosome integrity...
  25. Eric M Phizicky; Fiscal Year: 2016
    ..associated with non-syndromic X-linked mental retardation, and the corresponding TRM7 homolog from Schizosaccharomyces pombe is reported to be essential...
  26. Dissecting Translational Regulation by Genome-Wide Mapping of Initiation Factors
    OLIVIA SELFRIDGE RISSLAND; Fiscal Year: 2013
    ..Chris Norbury, which were funded by a Rhodes Scholarship, I uncovered an unknown mRNA decay pathway in Schizosaccharomyces pombe. Then, as a post-doctoral fellow in the laboratory of Dr...
  27. Structural and functional characterization of the Nbs1 N-terminus
    GERALD EDWARD DODSON; Fiscal Year: 2010
    ..To address this specific question the genetically tractable model organism Schizosaccharomyces pombe and a groundbreaking crystal structure of Nbs1 will be exploited to help identify novel interacting ..
  28. Kathleen L Gould; Fiscal Year: 2016
    ..essential for cytokinesis using a leading model organism for cytokinesis studies, the fission yeast Schizosaccharomyces pombe. We now propose to gain a better understanding of how these myriad proteins work together and under cell ..
  29. Toru Nakamura; Fiscal Year: 2016
    ..Therefore, we propose to utilize fission yeast Schizosaccharomyces pombe as a model system to investigate how telomere maintenance is ensured by collaboration among telomere ..
  30. Phong T Tran; Fiscal Year: 2015
    ..My laboratory uses the relatively simple fission yeast Schizosaccharomyces pombe and human cultured cells to address conserved mechanisms of spindle organization and function...
  31. Gerald R Smith; Fiscal Year: 2015
    ..In the fission yeast Schizosaccharomyces pombe, studies will focus on mutationally created hotspots in the ade6 gene and naturally occurring hotspots ..
  32. Fred Chang; Fiscal Year: 2016
    ..For our studies, we use a simple, genetically tractable model organism, the fission yeast Schizosaccharomyces pombe. A key process in division site placement is the localization of a cytokinesis factor mid1p to a medial ..
  33. Microtubule Organization and Nuclear Positioning
    Fred Chang; Fiscal Year: 2012
    ..Here, we study the molecular mechanisms that regulate the MT cytoskeleton, using the fission yeast Schizosaccharomyces pombe as a model organism...
  34. Gerald R Smith; Fiscal Year: 2016
    ..This research is focused on meiotic recombination in the fission yeast Schizosaccharomyces pombe, a widely studied model organism with features similar to those of multicellular eukaryotes, including ..
  35. Identifying Key Structural Elements in the Activation of the Arp2/3 Complex
    Patricia A Khuu; Fiscal Year: 2013
    ..Accordingly, using Schizosaccharomyces pombe, the fission yeast, we will employ directed mutations of specific amino acid residues in the Arp2/3 ..
  36. Structural Studies of RNA Maturation and Processing
    Christopher D Lima; Fiscal Year: 2013
    ..Capping enzymes also interact with the transcription elongation factor Spt5 and this occurs in fission yeast within the Spt5 C-terminal tandem nonapeptide repeats with the consensus sequence T1P2A3W4N5S6G7S8K9...
  37. STEWART H SHUMAN; Fiscal Year: 2016
    ..Our genetic dissection of what is essential for fission yeast CTD function is providing new insights to the CTD code, including: (i) structure-activity relations at ..
  38. PETER JOHN ESPENSHADE; Fiscal Year: 2014
    ..However, ascomycetous fungi like C. albicans lack the Site-2 protease. Our recent work in Schizosaccharomyces pombe identified a Golgi E3 ligase complex required for SREBP activation. C...
  39. Thomas D Pollard; Fiscal Year: 2015
    ..The fission yeast, S. pombe, is our experimental organism...
  40. RNAi and DNA Methylation Control Genomic Stability and Transcriptional Silencing
    JOHN KIMBLE FRAZER; Fiscal Year: 2010
    ..Using a Schizosaccharomyces pombe (fission yeast) model, we have discovered that RNAi is essential to prevent deletions within repetitive ..
  41. Molecular Mechanism of the Contractile-Ring Assembly in Fission Yeast Cytokinesis
    Jian Qiu Wu; Fiscal Year: 2013
    ..The fission yeast Schizosaccharomyces pombe has emerged as one of the leading model systems for the analysis of cytokinesis...
  42. Compartment Specific Signaling of Ras
    MARK REID PHILIPS; Fiscal Year: 2010
    ..We will study the mechanism of compartment specific Ras signaling in Schizosaccharomyces pombe. We will follow up an intriguing discovery that Ras in Drosophila is not membrane associated by studying ..
  43. Deciphering how tropomyosin regulates the actin filament
    SARAH ELLEN HITCHCOCK-DEGREGORI; Fiscal Year: 2013
    ..for molecular recognition by tropomyosin in the actin cytoskeleton in the cellular model system, Schizosaccharomyces pombe. We will test the requirement of conserved residues of yeast tropomyosin for growth, cytoskeletal ..
  44. Mechanism of the S-Phase DNA Damage Checkpoint
    NICHOLAS R RHIND; Fiscal Year: 2013
    ..These experiments will take advantage of the fission yeast Schizosaccharomyces pombe as a model system...
  45. Jeffrey A Pleiss; Fiscal Year: 2016
    ..as a regulatory control point, we have chosen to examine the genetically tractable fission yeast, Schizosaccharomyces pombe. In many ways, splicing in S. pombe looks similar to splicing in higher eukaryotes...
  46. Global Approaches to Protein Ubiquitylation
    Dieter A Wolf; Fiscal Year: 2010
    ..In Aim 2, SPASS will be employed for systematic profiling of E3s that cooperate with three other fission yeast ubiquitin E2s, the essential Ubc4p and Ubc11p, as well as Ubc2p, an enzyme broadly implicated in DNA repair ..
  47. Johan Paulsson; Fiscal Year: 2014
    ..coli, and an mRNA and protein survey in Schizosaccharomyces pombe. Each system was chosen because of the key principles illustrated, because of the central roles they ..
  48. MICHAEL CHARLES MARVIN; Fiscal Year: 2014
    ..the roles of SR proteins genome-wide in a genetically tractable system, the unicellular model organism Schizosaccharomyces pombe will be utilized. There are only two SR proteins in S...
  49. David R Kovar; Fiscal Year: 2016
    ..The unicellular fission yeast Schizosaccharomyces pombe is a superb model system for investigating formin biology because it is amenable to a wide-range of ..
  50. PETER JOHN ESPENSHADE; Fiscal Year: 2016
    ..discovery of sterol homeostasis regulators, we are studying the SREBP pathway in the fission yeast Schizosaccharomyces pombe. Yeast SREBP, called Sre1, functions in a new oxygen sensing pathway that mediates adaptation of cells ..
  51. A Schizosaccharomyces pombe Model of Birt-Hogg-Dube Syndrome
    ELIZABETH HENSKE; Fiscal Year: 2007
    This R21 application is focused on the BHD gene ortholog in the fission yeast Schizosaccharomyces pombe (S. pombe)...
  52. Chromatin Remodeling Complex in the spreading of silent heterochromatin
    KEVIN MICHAEL CREAMER; Fiscal Year: 2013
    ..While seemingly absent from budding yeast, a highly similar complex, SHREC, has been purified from the fission yeast S. pombe which appears to regulate heterochromatin in a manner similar to mammalian NuRD...
  53. Pre-mRNA Splicing in S. pombe: Genetics and Genomics
    JO WISE; Fiscal Year: 2004
    The goal of the proposed research is to use a combined genetic/genomic approach in the fission yeast Schizosaccharomyces pombe to understand the roles of exonic splicing enhancers and the proteins that recognize and respond to them...
  54. PRE-MRNA SPLICING IN SCHIZOSACCHAROMYCES POMBE
    David Frendewey; Fiscal Year: 1992
    ..proposed research is to characterize the biochemical mechanism of pre-mRNA splicing in the fission yeast Schizosaccharomyces pombe. To make progress toward this goal, the specific aims for the next funding period are (1) to ..
  55. CHROMOSOME SEGREGATION IN SCHIZOSACCHAROMYCES POMBE
    Louise Clarke; Fiscal Year: 1999
    ..This proposal describes the continuing development of the fission yeast (Schizosaccharomyces pombe) centromere system into a paradigm for the study of complex eukaryotic centromeres...
  56. Schizosaccharomyces pombe Ribonuclease P
    Donald Evans; Fiscal Year: 2003
    ..The composition of another eucaryal RNase P, that of the fission yeast Schizosaccharomyces pombe, has been predicted to be very different, consisting of an RNA molecule and a single 100 kD polypeptide...
  57. MECHANISMS OF MITOCHONDRIAL DIVISION AND INHERITANCE
    Michael Yaffe; Fiscal Year: 2004
    ..biochemical and genetic analysis using the budding yeast, Saccharomyces cerevisiae, and fission yeast, Schizosaccharomyces pombe, as model cellular systems...
  58. SUBSTRATE TARGETING OF CYCLIN DEPENDENT KINASE
    Janet Leatherwood; Fiscal Year: 2003
    ..In the fission yeast Schizosaccharomyces pombe, Cdc2, the fission yeast Cdk, binds to the DNA replication initiation factors Orp2 and Cdc18...
  59. RAS/CDC42 DEPENDENT SIGNAL TRANSDUCTION IN FISSION YEAST
    Stevan Marcus; Fiscal Year: 2000
    ..objective of this proposal is to study Ras and Cdc42-dependent signal transduction in the fission yeast, Schizosaccharomyces pombe. The fission yeast Ras protein homolog, Ras1, is required for two distinct cellular functions that ..
  60. GENE PRODUCT INTERACTIONS AND RADIORESISTANCE
    HOWARD LIEBERMAN; Fiscal Year: 1999
    ..e., checkpoint control. The fission yeast Schizosaccharomyces pombe is used as a model system in this study, because of its similarity to mammalian cells and ease of ..
  61. GENETIC CONTROL OF RADIORESISTANCE
    HOWARD LIEBERMAN; Fiscal Year: 1999
    ..The candidate primarily uses the fission yeast Schizosaccharomyces pombe as a model system to do so...
  62. James B Moseley; Fiscal Year: 2016
    ..The protein kinase Cdr2 connects cell size measurement with mitotic entry in fission yeast, and is part of a conserved family of protein kinases that down- regulate the mitotic inhibitor Wee1 in yeast ..
  63. Cell Cycle G2/M Pathway Modulated by Viral Protein R
    Richard Zhao; Fiscal Year: 2006
    ..In fission yeast (Schizosaccharomyces pombe), the activity of Cdc2 is regulated by the phosphorylation status of tyrosine 15 (Tyr 15) on Cdc2, which ..
  64. REGULATION OF MITOSIS IN FISSION YEAST
    Paul Russell; Fiscal Year: 2003
    ..These studies use the fission yeast Schizosaccharomyces pombe. Studies of fission yeast have pioneered the discovery of many features of cell cycle control...
  65. MOLECULAR ANALYSIS OF HOTSPOTS OF GENETIC RECOMBINATION
    Gerald Smith; Fiscal Year: 2007
    ..In the fission yeast Schizosaccharomyces pombe, studies will focus on the mutationally created M26 hotspot and the naturally occurring hotspot mbsl...
  66. Molecular Regulation of Alpha-Synuclein Misfolding and Toxicity in Two Yeast Mode
    SHUBHIK DEBBURMAN; Fiscal Year: 2009
    ..In published findings with budding yeast (Sharma et al. 2006) and fission yeast (Brandis et al...
  67. FUNCTIONAL MODEL FOR MITOSIS IN CELL LINES
    W Cande; Fiscal Year: 1999
    ..In Schizosaccharomyces pombe we have characterized a KRP, pk11, that is involved in spindle organization...
  68. Meiotic telemere clustering in fission yeast
    W Cande; Fiscal Year: 2006
    ..These characteristics make Schizosaccharomyces pombe an ideal organism to investigate the mechanism of bouquet formation by molecular, genetic and ..
  69. CONTROL OF THE EXIT FROM MITOSIS IN FISSION YEAST
    Shelley Sazer; Fiscal Year: 2002
    ..Because of its excellent genetics and cytology, fission yeast is an excellent experimental system in which to study this point in the cell cycle at which the chromosomes ..

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