Helicobacter pylori J99

Summary

Alias: Helicobacter pylori str. J99, Helicobacter pylori strain J99

Top Publications

  1. ncbi Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis
    Masanori Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Cancer Sci 96:835-43. 2005
  2. ncbi Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin
    Marina Aspholm-Hurtig
    Department of Odontology, Section of Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 305:519-22. 2004
  3. ncbi Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA
    Masanori Naito
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Gastroenterology 130:1181-90. 2006
  4. ncbi EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 280:23130-7. 2005
  5. pmc Random mutagenesis of Helicobacter pylori vacA to identify amino acids essential for vacuolating cytotoxic activity
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, and Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37232, USA
    Infect Immun 74:6188-95. 2006
  6. ncbi Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605, USA
    J Biol Chem 280:21107-14. 2005
  7. pmc NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein
    Sabine Brandt
    Department of Medical Microbiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Proc Natl Acad Sci U S A 102:9300-5. 2005
  8. pmc Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion
    Masato Suzuki
    Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato ku, Japan
    J Exp Med 202:1235-47. 2005
  9. pmc Interaction with CagF is required for translocation of CagA into the host via the Helicobacter pylori type IV secretion system
    Marc Roger Couturier
    Department of Medical Microbiology and Immunology, University of Alberta, 1 17 Medical Sciences Building, Edmonton, Alberta T6G 2R3, Canada
    Infect Immun 74:273-81. 2006
  10. ncbi Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation
    Eiki Yamasaki
    PRESTO, Japan Science and Technology Corporation, Saitama 332 0012, Japan
    J Biol Chem 281:11250-9. 2006

Patents

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
  2. Plants with increased yield
  3. Plants with increased yield
  4. Plants with increased yield and/or increased tolerance to environmental stress (iy-bm)
  5. Process for the production of a fine chemical
  6. Process for the production of lutein
  7. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
  8. Plants with increased yield (nue)
  9. Process for the production of fine chemicals
  10. Process for the control of production of fine chemicals

Scientific Experts

Detail Information

Publications95

  1. ncbi Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis
    Masanori Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Cancer Sci 96:835-43. 2005
    ..pylori strains carrying biologically more active CagA are more virulent than those with less active CagA and are more closely associated with gastric carcinoma...
  2. ncbi Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin
    Marina Aspholm-Hurtig
    Department of Odontology, Section of Oral Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 305:519-22. 2004
    ....
  3. ncbi Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA
    Masanori Naito
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Gastroenterology 130:1181-90. 2006
    ..Here we investigated the influence of EPIYA-repeat polymorphism on the CagA activity...
  4. ncbi EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells
    Hideaki Higashi
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 280:23130-7. 2005
    ..pylori infection...
  5. pmc Random mutagenesis of Helicobacter pylori vacA to identify amino acids essential for vacuolating cytotoxic activity
    Mark S McClain
    Department of Medicine, Vanderbilt University School of Medicine, and Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37232, USA
    Infect Immun 74:6188-95. 2006
    ..In addition, these are the first examples of mutant VacA proteins that have defects in vacuolating activity despite exhibiting channel activities similar to those of wild-type VacA...
  6. ncbi Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin
    Victor J Torres
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605, USA
    J Biol Chem 280:21107-14. 2005
    ..Reconstitution of toxin activity from two separate domains, as described here for VacA, has rarely been described for pore-forming bacterial toxins, which suggests that VacA is a pore-forming toxin with unique structural properties...
  7. pmc NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein
    Sabine Brandt
    Department of Medical Microbiology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Proc Natl Acad Sci U S A 102:9300-5. 2005
    ..Thus, CagA is a multifunctional protein capable of effecting both actin remodeling and potentiation of chemokine release...
  8. pmc Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion
    Masato Suzuki
    Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato ku, Japan
    J Exp Med 202:1235-47. 2005
    ..Thus, CagA targeting of Crk plays a central role in inducing the pleiotropic cell responses to H. pylori infection that cause several gastric diseases, including gastric cancer...
  9. pmc Interaction with CagF is required for translocation of CagA into the host via the Helicobacter pylori type IV secretion system
    Marc Roger Couturier
    Department of Medical Microbiology and Immunology, University of Alberta, 1 17 Medical Sciences Building, Edmonton, Alberta T6G 2R3, Canada
    Infect Immun 74:273-81. 2006
    ..Our results suggest that CagF may be a protein with unique chaperone-like function that is involved in the early steps of CagA recognition and delivery into the type IV secretion channel...
  10. ncbi Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation
    Eiki Yamasaki
    PRESTO, Japan Science and Technology Corporation, Saitama 332 0012, Japan
    J Biol Chem 281:11250-9. 2006
    ..These results suggest that VacA acts through different signaling pathways to induce apoptosis via Bax activation, independent of vacuolation...
  11. pmc CagA-producing Helicobacter pylori and increased risk of gastric cancer: a nested case-control study in Korea
    J Gwack
    Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul, 110 799, Korea
    Br J Cancer 95:639-41. 2006
    ..pylori-infected subjects (OR=3.57, 95% CI 1.05-12.14)...
  12. pmc In Helicobacter pylori, LuxS is a key enzyme in cysteine provision through a reverse transsulfuration pathway
    Neil C Doherty
    Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    J Bacteriol 192:1184-92. 2010
    ..pylori in a process of reverse transsulfuration. We recommend that the misnamed genes cysK(Hp) and metB(Hp) be renamed mccA (methionine-to-cysteine-conversion gene A) and mccB, respectively...
  13. ncbi Cloning and characterization of the fur gene from Helicobacter pylori
    S Bereswill
    Institute of Medical Microbiology and Hygiene, Department of Microbiology and Hygiene, Freiburg, Germany
    FEMS Microbiol Lett 159:193-200. 1998
    ..Comparison of Fur from H. pylori strain NCTC11638 with the recently published genomic DNA sequence of another strain (26695) confirmed the identity of the fur homologue and revealed that the fur locus is highly conserved in both strains...
  14. ncbi Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging
    D Ilver
    Department of Microbiology, Umea University, SE 901 87 Umea, Sweden
    Science 279:373-7. 1998
    ..pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori...
  15. pmc Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease
    J L Telford
    Department of Molecular Biology, Immunobiological Research Institute Siena, Italy
    J Exp Med 179:1653-58. 1994
    ..The cloning of the cytotoxin gene and the development of a mouse model of human gastric disease will provide the basis for the understanding of H. pylori pathogenesis and the development of therapeutics and vaccines...
  16. pmc Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain
    Kelly A Gangwer
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:16293-8. 2007
    ..Docking of the p55 structure into a 19-A cryo-EM map of a VacA dodecamer allows us to propose a model for how VacA monomers assemble into oligomeric structures capable of membrane channel formation...
  17. pmc Iron and pH homeostasis intersect at the level of Fur regulation in the gastric pathogen Helicobacter pylori
    Hanan Gancz
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Infect Immun 74:602-14. 2006
    ..This fact likely explains the requirement for this regulator for growth and colonization in the stomach...
  18. ncbi Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains
    T L Cover
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605
    J Biol Chem 269:10566-73. 1994
    ..8% amino acid identity with the corresponding region from tox+ strain 60190. Thus, sequence divergence in vacA genes may explain the lack of functionally active cytotoxin production by some H. pylori isolates...
  19. pmc Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells
    Kazuyuki Yokoyama
    Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Proc Natl Acad Sci U S A 102:9661-6. 2005
    ..pylori infection...
  20. pmc Elucidation of the Metabolic Network of Helicobacter pylori J99 and Malaysian Clinical Strains by Phenotype Microarray
    Woon Ching Lee
    Faculty of Medicine, Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
    Helicobacter 22:. 2017
    ..To understand the metabolic differences among H. pylori strains, we investigated four Malaysian H. pylori clinical strains, which had been previously sequenced, and a standard strain, H. pylori J99, at the phenotypic level...
  21. ncbi Identification of genome-derived vaccine candidates conserved between human and mouse-adapted strains of H. pylori
    Leonard Moise
    Brown University, Providence, Rhode Island, USA
    Hum Vaccin 4:219-23. 2008
    ..We screened the Helicobacter pylori J99 and 26695 genomes for T-cell epitopes using the epitope mapping algorithm EpiMatrix and selected 150 ..
  22. ncbi [Pathogenicity of hp jhp947 gene to C57BL/6 mice]
    Geqin Sun
    Research Center of Microbiology, Fujian Medical University, Fuzhou 350004, China
    Wei Sheng Wu Xue Bao 49:1109-14. 2009
    ..To study the effects of Helicobacter pylori jhp947 gene on the pathogenesis of epithelial cells and gene express pattern by animal studies...
  23. doi In silico investigation and structural characterization of virulent factor and a metallo peptidase present in Helicobacter pylori strain J99
    Megha Vaidya
    G H Patel P G Department of Computer Science and Technology, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India
    Interdiscip Sci 4:302-9. 2012
    VacA is a high-molecular weight multimeric pore-forming protein encoded by the chromosomal gene vacA of Helicobacter pylori J99 strian...
  24. doi Crystal structure of JHP933 from Helicobacter pylori J99 shows two-domain architecture with a DUF1814 family nucleotidyltransferase domain and a helical bundle domain
    Ji Young Yoon
    Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, 151 742, Republic of Korea
    Proteins 82:2275-81. 2014
    The jhp0933 gene in the plasticity region of Helicobacter pylori J99 encodes a hypothetical protein (JHP933), which may play some roles in pathogenesis. Here, we have determined the crystal structure of JHP933 at 2.17 Å...
  25. doi CsrA regulates Helicobacter pylori J99 motility and adhesion by controlling flagella formation
    Cheng Yen Kao
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Helicobacter 19:443-54. 2014
    ..Barnard et al. showed that CsrA appears to be necessary for full motility and the ability to infect mice, but its mechanism of regulation is still unclear...
  26. pmc Comparative genomics of Helicobacter pylori: analysis of the outer membrane protein families
    R A Alm
    Infection Discovery AstraZeneca R and D Boston, Waltham, Massachusetts 02451, USA
    Infect Immun 68:4155-68. 2000
    The two complete genomic sequences of Helicobacter pylori J99 and 26695 were used to compare the paralogous families (related genes within one genome, likely to have related function) of genes predicted to encode outer membrane proteins ..
  27. pmc Functional analysis of putative restriction-modification system genes in the Helicobacter pylori J99 genome
    H Kong
    New England Biolabs, 32 Tozer Road, Beverly, MA 01915, USA
    Nucleic Acids Res 28:3216-23. 2000
    ..Helicobacter pylori may maintain a variety of functional R-M systems, which are believed to be a primitive bacterial 'immune' system, by alternatively turning on/off a subset of numerous R-M systems...
  28. pmc Helicobacter pylori cagA 12-bp insertion can be a marker for duodenal ulcer in Okinawa, Japan
    Yuichi Matsuo
    Departments of Environmental and Preventive Medicine, Oita University, Yufu City, Oita, Japan
    J Gastroenterol Hepatol 28:291-6. 2013
    ..It has also been reported that J-Western-type cagA possesses a 12-bp insertion located in the 5' region of cagA sequence...
  29. pmc Novel functions for glycosyltransferases Jhp0562 and GalT in Lewis antigen synthesis and variation in Helicobacter pylori
    Mary Ann Pohl
    Infect Immun 80:1593-605. 2012
    ..In total, these results demonstrate that galT and jhp0562 have functions that cross the expected Le synthesis pathways and that jhp0562 provides a substrate for intragenomic recombination to generate diverse Le synthesis enzymes...
  30. pmc Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance
    Mathias Oertli
    Institute of Molecular Cancer Research, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 110:3047-52. 2013
    ..In conclusion, our results reveal the molecular players and mechanistic basis for H. pylori-induced immunomodulation, promoting persistent infection and conferring protection against allergic asthma...
  31. pmc Characterization of flgK gene and FlgK protein required for H. pylori colonization--from cloning to clinical relevance
    Jiunn Jong Wu
    Department of Medical Technology, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan, China
    World J Gastroenterol 12:3989-93. 2006
    ..To characterize the role of flgK and its protein product in H. pylori colonization...
  32. pmc Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori
    Jeffrey C Colbeck
    Center for Comparative Medicine, University of California, Davis, Davis, CA 95616, USA
    Infect Immun 74:4375-8. 2006
    ..We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time...
  33. pmc Conservation, localization and expression of HopZ, a protein involved in adhesion of Helicobacter pylori
    B Peck
    Chiron Behring GmbH and Co, Preclinical Research, PO Box 1630, D 35006 Marburg, Germany
    Nucleic Acids Res 27:3325-33. 1999
    ..Addionally the function of HopZ was investigated in an adhesion assay. The wild-type strain ATCC 43504 adhered to human gastric epithel cells whereas a knockout mutant strain showed significantly reduced binding to the cells...
  34. ncbi Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori
    Cong Han
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    FEBS J 273:4682-92. 2006
    ..mL(-1), respectively. This current work is expected to favor better understanding the features of SDH and provide useful information for the development of novel antibiotics to treat H. pylori-associated infection...
  35. ncbi Update on fluoroquinolone resistance in Helicobacter pylori: new mutations leading to resistance and first description of a gyrA polymorphism associated with hypersusceptibility
    Vincent Cattoir
    Laboratoire de bactériologie virologie hygiène, Centre Hospitalier, Universitaire Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris XII, Creteil, France
    Int J Antimicrob Agents 29:389-96. 2007
    ..The high rate of quinolone resistance in H. pylori requires the use/implication of a 'test and treat' strategy that can confidently rely on QRDR gyrA sequencing...
  36. ncbi Exploitation of structural and regulatory diversity in glutamate racemases
    Tomas Lundqvist
    AstraZeneca Global Structural Chemistry, AstraZeneca R and D Molndal, SE 431 83, Molndal, Sweden
    Nature 447:817-22. 2007
    ..These structural, kinetic and mutational studies provide insight into the physiological regulation of these essential enzymes and provide a basis for designing narrow-spectrum antimicrobial agents...
  37. pmc Helicobacter pylori VacA enhances prostaglandin E2 production through induction of cyclooxygenase 2 expression via a p38 mitogen-activated protein kinase/activating transcription factor 2 cascade in AZ-521 cells
    Junzo Hisatsune
    Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan
    Infect Immun 75:4472-81. 2007
    ..Thus, VacA enhances PGE(2) production by AZ-521 cells through induction of COX-2 expression via the p38 MAPK/ATF-2 cascade, leading to activation of the CRE site in the COX-2 promoter...
  38. ncbi Use of SiRNA to investigate the role of CagA on H. pylori induced IL-8 production from gastric epithelial cells
    Yanguo Yan
    Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital Research Center for Gastric Cancer, Sun Yat Sen University, Guangzhou 510080, China
    Hepatogastroenterology 54:1868-73. 2007
    ..H. pylori infection can stimulate gastric epithelial cells to release IL-8. We studied the effect of small interference RNA (SiRNA) on CagA expression and the H. pylori-induced release of IL-8 by gastric epithelial cells...
  39. pmc Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions
    Toni A Nagy
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Am J Pathol 178:1448-52. 2011
    ..These events are mediated by the cag pathogenicity island and by mitogen-activated protein kinases, suggesting that eosinophil migration orchestrated by H. pylori is regulated by a virulence-related locus...
  40. pmc Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: a meta-analysis
    Shuo Zhang
    Department of Neurology, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China
    World J Gastroenterol 14:1286-92. 2008
    ..To study the relationship between the cytotoxin-associated gene-A (CagA) status of H pylori strains and cerebral infarction among European Caucasians and Chinese Han by conducting a meta-analysis...
  41. pmc The beta1 integrin activates JNK independent of CagA, and JNK activation is required for Helicobacter pylori CagA+-induced motility of gastric cancer cells
    Jared L Snider
    Department of Microbiology and Immunology and the Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Biol Chem 283:13952-63. 2008
    ..We report for the first time that H. pylori mediates CagA-independent signaling that promotes cell motility through the beta1 integrin pathway...
  42. ncbi Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori
    Y Ito
    Second Department of Internal Medicine, Fukui Medical University, Japan
    J Infect Dis 178:1391-8. 1998
    ..The phylogenetic tree based on the vacA open-reading frame indicated that two different H. pylori lineages are circulating in Japan and the West...
  43. doi vacA i-region subtyping
    Hiroaki Ogiwara
    Gastroenterology 134:1267; author reply 1268. 2008
  44. pmc The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis
    Tiancen Hu
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    J Biol Chem 283:21284-93. 2008
    ..Our work is expected to provide clues for designing specific inhibitors of DAPDC...
  45. doi Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA
    M Hatakeyama
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 27:7047-54. 2008
    ..These findings indicate that loss of cell polarity underlies the abnormal proliferation of epithelial cells that directs carcinogenesis...
  46. ncbi [Helicobacter pylori cytotoxin associated protein CagA regulates gastrin gene promoter activity]
    Yan Zhao
    The Key Laboratory of Molecular Biology, Guiyang Medical College, Guiyang 550004, China
    Zhonghua Zhong Liu Za Zhi 32:501-6. 2010
    ..To study the regulatory effect of Helicobacter pylori CagA protein on gastrin promoter and the related signaling pathways as to further elucidate the mechanism of the development and progression of human gastric carcinoma...
  47. doi Identification of glycoprotein receptors within the human salivary proteome for the lectin-like BabA and SabA adhesins of Helicobacter pylori by fluorescence-based 2-D bacterial overlay
    Anke Walz
    Department of Operative Dentistry and Periodontology, Dental School, University of Regensburg, Regensburg, Germany
    Proteomics 9:1582-92. 2009
    ..In general, this 2-D bacterial overlay technique represents a useful supplement in adhesion studies of bacteria with complex protein mixtures...
  48. pmc Effect of FliK mutation on the transcriptional activity of the {sigma}54 sigma factor RpoN in Helicobacter pylori
    Francois P Douillard
    Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Western Road, Cork, Ireland
    Microbiology 155:1901-11. 2009
    ..FliK thus appears to be involved in three processes: hook-length control, export substrate specificity and control of RpoN transcriptional activity...
  49. ncbi vacA genotypes in oral cavity and Helicobacter pylori seropositivity among adults without dyspepsia
    Gloria Fernández-Tilapa
    Unidad Académica de Ciencias Químico Biológicas, Universidad Autonoma de Guerrero, Chilpancingo, Guerrero, Mexico
    Med Oral Patol Oral Cir Bucal 16:e175-80. 2011
    ..pylori in oral cavity and oral hygiene. The seroprevalence of anti-H. pylori antibodies and its associated factors were analyzed too...
  50. pmc Helicobacter pylori glutamine synthetase lacks features associated with transcriptional and posttranslational regulation
    R M Garner
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 66:1839-47. 1998
    ..We conclude that glutamine synthetase is critical for nitrogen assimilation in H. pylori and is active under all physiologic conditions...
  51. pmc A comprehensive sequence and disease correlation analyses for the C-terminal region of CagA protein of Helicobacter pylori
    Youlin Xia
    Department of Biology and Biochemistry, University of Houston, Houston, TX, USA
    PLoS ONE 4:e7736. 2009
    ..Our results shed light on the relationships between the types of CagAs, the country of origin of each sequence type, and the frequency of gastric disease...
  52. doi Prevalence of cagA and vacA genotypes of Helicobacter pylori isolated from Turkish patients with active or non-active chronic gastritis
    Birol Safak
    Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Kocatepe University, Afyonkarahisar, Turkey
    Scand J Infect Dis 42:435-8. 2010
    ..8% vs 21.6% (p = 0.02) and 78.0% vs 40.5% (p < 0.001), respectively). In conclusion, both cagA and vacAs1 genotypes are associated with the activity of chronic gastritis...
  53. pmc Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin
    Susan E Ivie
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Microbiol 10:60. 2010
    ..To test this hypothesis, we introduced eight deletion mutations (each corresponding to a single coil within a beta-helical segment spanning VacA amino acids 433-628) into the H. pylori chromosomal vacA gene...
  54. pmc Helicobacter pylori lipopolysaccharide is synthesized via a novel pathway with an evolutionary connection to protein N-glycosylation
    Isabelle Hug
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    PLoS Pathog 6:e1000819. 2010
    ..We conclude that H. pylori uses a novel LPS biosynthetic pathway, evolutionarily connected to bacterial protein N-glycosylation...
  55. pmc In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription
    Feifei Shen
    Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    BMC Microbiol 10:210. 2010
    ..In this study, we investigated whether and how LuxS controls motility of H. pylori, specifically if it has its effects via luxS-required cysteine metabolism or via AI-2 synthesis only...
  56. pmc Crystal structure of oxidized flavodoxin, an essential protein in Helicobacter pylori
    Jörg Freigang
    Fachbereich Biologie, Universitat Konstanz, D 78457 Konstanz, Germany
    Protein Sci 11:253-61. 2002
    ..We also show that flavodoxin is essential for the survival of H. pylori, and conclude that its structure can be used as a starting point for the modeling of an inhibitor for the interaction between the POR-enzyme complex and flavodoxin...
  57. pmc Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella
    M Kostrzynska
    Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada
    J Bacteriol 173:937-46. 1991
    ..pylori, suggesting that this serological test could be a useful addition to those currently employed in the rapid identification of this important pathogen...
  58. pmc Construction of expression systems for flaA and flaB genes of Helicobacter pylori and determination of immunoreactivity and antigenicity of recombinant proteins
    Jie Yan
    Department of Medical Microbiology and Parasitology, College of Medical Sciences, Zhejiang University, 353 Yan An Road, Hangzhou 310031, Zhejiang Province, China
    World J Gastroenterol 9:2240-50. 2003
    ..To clone flagellin genes A (flaA) and B (flaB) from a clinical strain of Helicobacter pylori (H pylori) and to construct prokaryotic expression systems of the genes and identify immunity of the fusion proteins...
  59. ncbi Analysis of geospecific markers for Helicobacter pylori variants in patients from Japan and Nigeria by triple-locus nucleotide sequence typing
    Robert J Owen
    Laboratory of Enteric Pathogens, Specialist and Reference Microbiology Division, Health Protection Agency, London NW9 5HT, UK
    Microbiology 150:151-61. 2004
    ..The findings provide unique evidence of positive selection for conserved nucleotide sites linked to the geographical separation in Japan of a strain subpopulation for which we propose the designation H. pylori geovar 'orientalis'...
  60. pmc Construction of prokaryotic expression system of ureB gene from a clinical Helicobacter pylori strain and identification of the recombinant protein immunity
    Ya Fei Mao
    Department of Medical Microbiology and Parasitology, College of Medical Science, Zhejiang University, 353 Yanan Road, Hangzhou 310031, Zhejiang Province, China
    World J Gastroenterol 10:977-84. 2004
    ..To clone ureB gene from a clinical isolate of Helicobacter pylori and construct a prokaryotic expression system of the gene and identify immunity of the expressed recombinant protein...
  61. ncbi Molecular cloning and characterization of a new peptide deformylase from human pathogenic bacterium Helicobacter pylori
    Cong Han
    Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Biochem Biophys Res Commun 319:1292-8. 2004
    ..This present work thereby supplies a potential platform that facilitates the discovery of novel HpPDF inhibitors and further of possible antimicrobial agents against H. pylori...
  62. ncbi Positive selection scanning reveals decoupling of enzymatic activities of carbamoyl phosphate synthetase in Helicobacter pylori
    Wagied Davids
    Department of Biochemistry and Biophysics and Stockholm Bioinformatics Center, Stockholm University, 10691 Stockholm, Sweden
    J Mol Evol 54:458-64. 2002
    ..Implications of these findings for a metabolic enzyme under positive selection are discussed in terms of the mechanisms of H. pylori pathogenesis...
  63. pmc A new subtype of 3' region of cagA gene in Helicobacter pylori strains isolated from Zhejiang Province in China
    Ran Tao
    Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, 353 Yan An Road, Hangzhou 310006, Zhejiang Province, China
    World J Gastroenterol 10:3284-8. 2004
    ..To isolate the subtypes of 3' region of cagA gene in Helicobacter pylori (H pylori) strains from Zhejiang Province in China and to investigate their relations to H pylori-associated gastroduodenal diseases...
  64. pmc The putative neuraminyllactose-binding hemagglutinin HpaA of Helicobacter pylori CCUG 17874 is a lipoprotein
    P W O'Toole
    Astra Arcus AB, Sodertalje, Sweden
    J Bacteriol 177:6049-57. 1995
    ..The data collectively suggest that HpaA is a nonessential lipoprotein internal to the H. pylori cell and that it is not involved in adhesion...
  65. pmc Genetic and transmission analysis of Helicobacter pylori strains within a family
    Josette Raymond
    Service de Microbiologie, Hopital Saint Vincent de Paul, 75014 Paris, France
    Emerg Infect Dis 10:1816-21. 2004
    ..Several mechanisms, such as point mutations, intragenic recombination, and introduction of foreign (African) alleles, were shown to enhance strain diversity within the family...
  66. pmc Cloning and sequencing of cagA gene fragment of Helicobacter pylori with coccoid form
    Ke xia Wang
    School of Medicine, Anhui University of Science and Technology, Huainan 232001, Anhui Province, China
    World J Gastroenterol 10:3511-3. 2004
    ..To clone and sequence the cagA gene fragment of Helicobacter pylori (H pylori) with coccoid form...
  67. ncbi A role for CagA/VacA in Helicobacter pylori inhibition of murine duodenal mucosal bicarbonate secretion
    Bi guang Tuo
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California 92103, USA
    Dig Dis Sci 49:1845-52. 2004
    ..The ability of virulent HP strains to inhibit duodenal bicarbonate secretion through multiple intracellular pathways likely contributes to the pathogenesis of HP-associated duodenal ulcer disease...
  68. ncbi Helicobacter nemestrinae ATCC 49396T is a strain of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989, and Helicobacter nemestrinae Bronsdon et al. 1991 is therefore a junior heterotypic synonym of Helicobacter pylori
    Sebastian Suerbaum
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Germany
    Int J Syst Evol Microbiol 52:437-9. 2002
    ..nemestrinae ATCC 49396T is really a strain of H. pylori and that H. nemestrinae Bronsdon et al. 1991 is a junior heterotypic synonym of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989...
  69. ncbi The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a TLR4- and apoptosis signal-regulating kinase 1-dependent manner
    Chaitali Basak
    Department of Chemistry, Bose Institute, Kolkata, India
    J Immunol 174:5672-80. 2005
    ....
  70. ncbi A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs
    H A Lewis
    Structural GenomiX, San Diego, CA 92121, USA
    Structure 9:527-37. 2001
    ..LuxS and AI-2 have been described in both Gram-negative and Gram-positive bacterial species and have been shown to be involved in the expression of virulence genes in several pathogens...
  71. pmc Essential thioredoxin-dependent peroxiredoxin system from Helicobacter pylori: genetic and kinetic characterization
    L M Baker
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Bacteriol 183:1961-73. 2001
    ..H. pylori AhpC was not reduced by Salmonella typhimurium AhpF and was slightly more active with E. coli TrxR and Trx1 than was S. typhimurium AhpC, demonstrating the specialized catalytic properties of this peroxiredoxin...
  72. ncbi Molecular cloning and functional expression of a novel Helicobacter pylori alpha-1,4 fucosyltransferase
    Said Rabbani
    Institute of Molecular Pharmacy, Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Glycobiology 15:1076-83. 2005
    ..Additionally, the enzyme possesses a broad tolerance toward nonnatural Type I acceptor substrate analogs and therefore represents a valuable tool for the chemoenzymatic synthesis of Lewis A, sialyl Lewis A as well as mimetics thereof...
  73. ncbi Solution structure of HP1242 from Helicobacter pylori
    Su Jin Kang
    National Laboratory of Membrane Protein Structure, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea
    Proteins 61:1111-3. 2005
  74. ncbi Nucleotide sequence and mutational analysis indicate that two Helicobacter pylori genes encode a P-type ATPase and a cation-binding protein associated with copper transport
    Z Ge
    Department of Medical Microbiology and Infectious Diseases, University of Alberta, Edmonton, Canada
    Mol Microbiol 15:97-106. 1995
    ..The results obtained indicate that ORF1 and ORF2 comprise a cation-transporting system which is associated with copper export out of the H. pylori cells...
  75. pmc Mechanism of metronidazole resistance in Helicobacter pylori: comparison of the rdxA gene sequences in 30 strains
    N M Solcà
    Istituto Cantonale Batteriosierologico, 6904 Lugano, Switzerland
    Antimicrob Agents Chemother 44:2207-10. 2000
    ..Moreover, phylogenetic analysis of the 30 nucleotide sequences did not demonstrate specific clusters associated with the resistance phenotype...
  76. ncbi The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins
    M S Alphey
    Department of Biochemistry, The Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, UK
    J Mol Biol 300:903-16. 2000
    ....
  77. ncbi Characterization and inhibitor discovery of one novel malonyl-CoA: acyl carrier protein transacylase (MCAT) from Helicobacter pylori
    Weizhi Liu
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China
    FEBS Lett 580:697-702. 2006
    ..pylori strain, and corytuberine might be used as a potential lead compound in the discovery of the antibacterial agents using HpMCAT as target...
  78. ncbi A C-terminal translocation signal is necessary, but not sufficient for type IV secretion of the Helicobacter pylori CagA protein
    Sabine Hohlfeld
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Pettenkoferstr 9a, D 80336 Munich, Germany
    Mol Microbiol 59:1624-37. 2006
    ..Thus, the Cag type IV secretion system seems to diverge from other systems not only with respect to its composition and architecture, but also in terms of substrate recognition and transport...
  79. pmc The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses
    Amedeo Amedei
    Department of Internal Medicine, University of Florence, Florence, Italy
    J Clin Invest 116:1092-101. 2006
    ..pylori-infected patients. These data indicate HP-NAP as an important factor of H. pylori able to elicit cells of the innate immune system to produce IL-12 and IL-23, and they suggest it as a new tool for promoting Th1 immune responses...
  80. pmc Isolation of recombinant protective Helicobacter pylori antigens
    D Hocking
    Research and Development Division, CSL Limited, Parkville, Victoria, Australia 3052
    Infect Immun 67:4713-9. 1999
    ..pylori, as judged by an assay of gastric urease activity and light microscopy on stomach sections. These results clearly indicate that the screening strategy has successfully identified candidate vaccine antigens...
  81. ncbi Acid-induced expression of an LPS-associated gene in Helicobacter pylori
    C C McGowan
    Department of Medicine, Vanderbilt University Medical School, and Department of Veterans Affairs Medical Center, Nashville, TN, USA
    Mol Microbiol 30:19-31. 1998
    ..pylori cells grown at pH 5 compared with pH 7, which suggests that H. pylori may alter its LPS structure in response to acidic pH. This may be an important adaptation facilitating H. pylori colonization of the acidic gastric environment...
  82. ncbi [Construction of hp0523 gene mutant in Helicobacter pylori Cag-PAI and the influence on the ability of CagA protein translocation]
    Qiao Zhong
    Department of Microbiology, Medical Technology School of Jiangsu University, Zhenjiang 212001, China
    Wei Sheng Wu Xue Bao 49:460-4. 2009
    ..To construct the hp0523 gene mutant of Helicobacter pylori and investigate the function of hp0523 gene...
  83. pmc Helicobacter pylori CagA induces AGS cell elongation through a cell retraction defect that is independent of Cdc42, Rac1, and Arp2/3
    Kevin M Bourzac
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    Infect Immun 75:1203-13. 2007
    ..Thus, our data implicate a set of signaling molecules in the hummingbird phenotype that are different than the molecules previously suspected...
  84. ncbi Topoisomerase I of Helicobacter pylori: juxtaposition with a flagellin gene (flaB) and functional requirement of a fourth zinc finger motif
    S Suerbaum
    Ruhr Universitat Bochum, Medizinische Mikrobiologie und Immunologie, Bochum, Germany
    Gene 210:151-61. 1998
    ..These data show that TopA proteins can be divided into several classes on the basis of zinc finger motifs and raise the interesting possibility that the H. pylori enzyme has local topological effects focussed on a flagellin gene...
  85. ncbi Cloning and genetic characterization of a Helicobacter pylori flagellin gene
    H Leying
    Max Planck Institut fur Biologie, Abteilung Infektions biologie, Tubingen, Germany
    Mol Microbiol 6:2863-74. 1992
    ..coli plasmid expression system suggest that a distinct nucleotide sequence in the gene interferes with productive translation of this protein in E. coli...
  86. pmc Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa
    Ana Magalhaes
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Glycobiology 19:1525-36. 2009
    ..pylori strains, with different adhesin expression profiles, we have demonstated an impairment of BabA-dependent adhesion of H. pylori to Fut2-null mice gastric mucosa, whereas SabA-mediated binding was not affected...
  87. pmc Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo
    Dana M Bronte-Tinkew
    Department of Pediatrics and Physiology, University of Toronto, Toronto, Canada
    Cancer Res 69:632-9. 2009
    ..Collectively, these results indicate that H. pylori CagA activates the STAT3 signaling pathway in vitro and in vivo, providing a potential mechanism by which chronic H. pylori infection promotes the development of gastric cancer...
  88. ncbi Detection of VacA gene specific for Helicobactor pylori in hepatocellular carcinoma and cholangiocarcinoma specimens of Thai patients
    Kawin Leelawat
    Division of Surgery, Rajavithi Hospital, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 38:881-5. 2007
    ..The selected amplicons revealed high homology compared with H. pylori VacA sequence. H. pylori VacA gene was detected in all primary liver cancer specimens and in 71% (5/7) of control liver specimens...
  89. ncbi Novel sequence organization and insertion specificity of IS605 and IS606: chimaeric transposable elements of Helicobacter pylori
    D Kersulyte
    Departments of Molecular Microbiology and Genetics, Campus Box 8230, Washington University School of Medicine, St Louis, MO 63110, USA
    Gene 223:175-86. 1998
    ..The features of these two chimaeric IS elements are discussed in terms of possible transposition mechanisms, IS element evolution, and effects of IS elements on genome organization and evolution in the microbes that they inhabit...
  90. ncbi Requirement of nickel metabolism proteins HypA and HypB for full activity of both hydrogenase and urease in Helicobacter pylori
    J W Olson
    Department of Microbiology, 813 Biological Sciences Building, University of Georgia, Athens, GA 30602, USA
    Mol Microbiol 39:176-82. 2001
    ....
  91. pmc Diverse phenotypes resulting from polyphosphate kinase gene (ppk1) inactivation in different strains of Helicobacter pylori
    Shumin Tan
    Department of Molecular Microbiology, Washington University Medical School, St Louis, MO 63110, USA
    J Bacteriol 187:7687-95. 2005
    ..pylori's high genetic diversity makes it well suited for studies of such interactions, their underlying mechanisms, and their evolutionary consequences...
  92. ncbi Evaluation of the homologous recombination in Helicobacter pylori
    Slovénie Pyndiah
    INSERM ESPRI 2004, Laboratoire de Bacteriologie, UniversitéVictor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    Helicobacter 10:185-92. 2005
    ..Most strategies for direct mutagenesis of Helicobacter pylori primarily involve genomic DNA cloning which is a time-consuming and expensive technique...
  93. pmc Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A
    An X Tran
    Department of Microbiology, J H Quillen College of Medicine, Johnson City, TN 37614, USA
    J Biol Chem 279:55780-91. 2004
    ..pylori lipid A. In summary, we demonstrate that modification of the 1-phosphate group of H. pylori lipid A requires two enzymatic steps...
  94. pmc Characterization and immunogenicity of the CagF protein of the cag pathogenicity island of Helicobacter pylori
    Anke Seydel
    Dipartimento di Scienze Biomediche Sperimentali, Università degli Studi di Padova Istituto Veneto di Medicina Molecolare, I 35121 Padua, Italy
    Infect Immun 70:6468-70. 2002
    ..pylori G27 and that the protein is always expressed with electrophoretic mobility variations among the 20 strains tested here. We have also found that natural infection with H. pylori is able to induce antibodies against CagF...
  95. ncbi Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides
    Miguel A Valvano
    Department of Microbiology and Immunology and Medicine, University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Microbiology 148:1979-89. 2002

Research Grants7

  1. DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDY
    Harvey Risch; Fiscal Year: 2002
    ..abstract_text> ..
  2. CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGY
    Harvey Risch; Fiscal Year: 2002
    ....
  3. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2008
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. [unreadable] [unreadable]..
  4. Transcription of H. pylori Genes in the Rhesus Monkey
    JAY SOLNICK; Fiscal Year: 2002
    ..An understanding of the dynamic interaction between host and pathogen may point the way toward critical proteins that may be useful as targets for therapy or vaccine development. ..
  5. Transmission of H. pylori infection in the rhesus monkey
    JAY SOLNICK; Fiscal Year: 2005
    ..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding. ..
  6. Gene expression during H. pylori-host interactions
    JAY SOLNICK; Fiscal Year: 2007
    ..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
  7. Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    JAY SOLNICK; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..

Patents16

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  2. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  3. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  4. Plants with increased yield and/or increased tolerance to environmental stress (iy-bm)
    Patent Number: WO2009077611-A2; Date:2009-06-25
  5. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  6. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  7. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  8. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  9. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  10. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  11. NOVEL DNA POLYMERASE III HOLOENZYME DELTA SUBUNIT NUCLEIC ACID MOLECULES AND PROTEINS
    Patent Number: JP2004508018-A; Date:2004-03-18
  12. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  13. RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES
    Patent Number: KR1020130117753-A; Date:2013-10-28
  14. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  15. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27
  16. Relaxase and other vir proteins as targets for treatment of helicobacter pylori infection and as dna transfer system to mammalian cells
    Patent Number: WO0130810-A2; Date:2001-05-03