Helicobacter pylori HPAG1

Summary

Alias: Helicobacter pylori str. HPAG1, Helicobacter pylori strain HPAG1

Top Publications

  1. ncbi Crystal structure of the type II 3-dehydroquinase from Helicobacter pylori
    Byung Il Lee
    Laboratory of Structural Proteomics, School of Chemistry and Molecular Engineering, Seoul National University, Seoul, Korea
    Proteins 51:616-7. 2003
  2. ncbi Purification and characterization of the vacuolating toxin from Helicobacter pylori
    T L Cover
    Infectious Disease Section, Department of Veterans Affairs Medical Center, Nashville, Tennessee 37212
    J Biol Chem 267:10570-5. 1992
  3. pmc The Helicobacter pylori genome is modified at CATG by the product of hpyIM
    Q Xu
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Bacteriol 179:6807-15. 1997
  4. pmc The putative neuraminyllactose-binding hemagglutinin HpaA of Helicobacter pylori CCUG 17874 is a lipoprotein
    P W O'Toole
    Astra Arcus AB, Sodertalje, Sweden
    J Bacteriol 177:6049-57. 1995
  5. pmc Crystal structures of 3-methyladenine DNA glycosylase MagIII and the recognition of alkylated bases
    Brandt F Eichman
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    EMBO J 22:4898-909. 2003
  6. pmc Crystal structure of oxidized flavodoxin, an essential protein in Helicobacter pylori
    Jörg Freigang
    Fachbereich Biologie, Universitat Konstanz, D 78457 Konstanz, Germany
    Protein Sci 11:253-61. 2002
  7. ncbi Molecular cloning and characterization of a new peptide deformylase from human pathogenic bacterium Helicobacter pylori
    Cong Han
    Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Biochem Biophys Res Commun 319:1292-8. 2004
  8. ncbi Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains
    T L Cover
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605
    J Biol Chem 269:10566-73. 1994
  9. pmc Properties of the P-type ATPases encoded by the copAP operons of Helicobacter pylori and Helicobacter felis
    D Bayle
    University of California Los Angeles and Wadsworth Veterans Affairs Medical Center, USA
    J Bacteriol 180:317-29. 1998
  10. pmc Helicobacter pylori hydrogenase accessory protein HypA and urease accessory protein UreG compete with each other for UreE recognition
    Stéphane L Benoit
    Department of Microbiology, University of Georgia, 805 Biological Sciences Bldg, Athens, GA, USA
    Biochim Biophys Acta 1820:1519-25. 2012

Scientific Experts

  • P Loewen
  • Renata Godlewska
  • Sebastian Suerbaum
  • D H Kwon
  • S Bereswill
  • W G Dundon
  • JAY SOLNICK
  • Cong Han
  • Weizhi Liu
  • Xu Shen
  • Hualiang Jiang
  • Stéphane L Benoit
  • B Peck
  • Yanyan Bai
  • Darius Jean Namdjou
  • Kun Zhuang
  • Han Yu Sun
  • Mercedes Alfonso-Prieto
  • Gina Boanca
  • Kaixian Chen
  • David A Robinson
  • Jianhua Cai
  • Ping Cao
  • Y Ito
  • Slovénie Pyndiah
  • Elena Papinutto
  • Jianmin Yue
  • Nunilo Cremades
  • Laurent Terradot
  • Yiming Yang
  • Shuying Peng
  • Gabriel Waksman
  • Thomas J Reilly
  • Ya Fei Mao
  • Monique M Gerrits
  • Tzu Lung Lin
  • Byung Il Lee
  • Savvas N Savvides
  • Dong Young Kim
  • Brandt F Eichman
  • Giselle Soto
  • Britta M Björkholm
  • Jörg Freigang
  • Takeshi Okamoto
  • Stephanie A Hill
  • B Björkholm
  • R Paul
  • Jonathan L McMurry
  • Z Ge
  • Robert J Maier
  • N C Ha
  • M J Blaser
  • M S Alphey
  • B Knapp
  • E Hundt
  • N M Solcà
  • M Ortkamp
  • T L Cover
  • F Fassbinder
  • D E Taylor
  • H J Yeo
  • Wei Zhang
  • Xia Bai
  • Ziqiang Yu
  • Changgeng Ruan
  • K Melchers
  • Zhaoyue Wang
  • K P Schäfer
  • Lijuan Cao
  • Warren W Wakarchuk
  • Stephen G Withers
  • Hong Ming Chen
  • Denis Brochu
  • G Wang
  • Evguenii Vinogradov
  • M Shirai
  • Aaron Sand
  • Jian Zhong Zhang
  • Li Zhang
  • Jia Fu Pan
  • Jun Zhang
  • Chun Hung Lin
  • Hidehiko Kumagai
  • Keiichi Fukuyama
  • Chia Ling Liu
  • Chun Nan Lin
  • Carme Rovira
  • Ling Xia Zhang
  • Andrew H J Wang
  • Anton Borovik

Detail Information

Publications62

  1. ncbi Crystal structure of the type II 3-dehydroquinase from Helicobacter pylori
    Byung Il Lee
    Laboratory of Structural Proteomics, School of Chemistry and Molecular Engineering, Seoul National University, Seoul, Korea
    Proteins 51:616-7. 2003
  2. ncbi Purification and characterization of the vacuolating toxin from Helicobacter pylori
    T L Cover
    Infectious Disease Section, Department of Veterans Affairs Medical Center, Nashville, Tennessee 37212
    J Biol Chem 267:10570-5. 1992
    ..424 +/- 0.06 versus 0.182 +/- 0.02, p = 0.0009). Finally, ELISA recognition of the purified M(r) = 87,000 protein by human sera was significantly associated with toxin-neutralizing activity (p = 0.019, r = 0.518)...
  3. pmc The Helicobacter pylori genome is modified at CATG by the product of hpyIM
    Q Xu
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Bacteriol 179:6807-15. 1997
    ..We conclude that hpyIM encodes a DNA methyltransferase, M.HpyI, that is well conserved among diverse H. pylori strains and that modifies H. pylori genomes at CATG sites...
  4. pmc The putative neuraminyllactose-binding hemagglutinin HpaA of Helicobacter pylori CCUG 17874 is a lipoprotein
    P W O'Toole
    Astra Arcus AB, Sodertalje, Sweden
    J Bacteriol 177:6049-57. 1995
    ..The data collectively suggest that HpaA is a nonessential lipoprotein internal to the H. pylori cell and that it is not involved in adhesion...
  5. pmc Crystal structures of 3-methyladenine DNA glycosylase MagIII and the recognition of alkylated bases
    Brandt F Eichman
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    EMBO J 22:4898-909. 2003
    ..We report base excision and DNA binding activities of MagIII active site mutants, together with a structural comparison of the HhH glycosylases...
  6. pmc Crystal structure of oxidized flavodoxin, an essential protein in Helicobacter pylori
    Jörg Freigang
    Fachbereich Biologie, Universitat Konstanz, D 78457 Konstanz, Germany
    Protein Sci 11:253-61. 2002
    ..We also show that flavodoxin is essential for the survival of H. pylori, and conclude that its structure can be used as a starting point for the modeling of an inhibitor for the interaction between the POR-enzyme complex and flavodoxin...
  7. ncbi Molecular cloning and characterization of a new peptide deformylase from human pathogenic bacterium Helicobacter pylori
    Cong Han
    Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Biochem Biophys Res Commun 319:1292-8. 2004
    ..This present work thereby supplies a potential platform that facilitates the discovery of novel HpPDF inhibitors and further of possible antimicrobial agents against H. pylori...
  8. ncbi Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains
    T L Cover
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605
    J Biol Chem 269:10566-73. 1994
    ..8% amino acid identity with the corresponding region from tox+ strain 60190. Thus, sequence divergence in vacA genes may explain the lack of functionally active cytotoxin production by some H. pylori isolates...
  9. pmc Properties of the P-type ATPases encoded by the copAP operons of Helicobacter pylori and Helicobacter felis
    D Bayle
    University of California Los Angeles and Wadsworth Veterans Affairs Medical Center, USA
    J Bacteriol 180:317-29. 1998
    ..The data suggest that H. pylori and H. felis employ conserved mechanisms of ATPase-dependent copper resistance...
  10. pmc Helicobacter pylori hydrogenase accessory protein HypA and urease accessory protein UreG compete with each other for UreE recognition
    Stéphane L Benoit
    Department of Microbiology, University of Georgia, 805 Biological Sciences Bldg, Athens, GA, USA
    Biochim Biophys Acta 1820:1519-25. 2012
    ....
  11. pmc Comparison of genetic divergence and fitness between two subclones of Helicobacter pylori
    B Björkholm
    Swedish Institute for Infectious Disease Control, 171 82 Solna, Karolinska Institute, 171 77 Stockholm, Sweden
    Infect Immun 69:7832-8. 2001
    ..Together, these results reveal that the H. pylori population infecting one individual can undergo significant divergence, creating stable subclones with substantial genotypic and phenotypic differences...
  12. ncbi Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori
    Y Ito
    Second Department of Internal Medicine, Fukui Medical University, Japan
    J Infect Dis 178:1391-8. 1998
    ..The phylogenetic tree based on the vacA open-reading frame indicated that two different H. pylori lineages are circulating in Japan and the West...
  13. ncbi Construction of prokaryotic expression system of ureB gene from a clinical Helicobacter pylori strain and identification of the recombinant protein immunity
    Ya Fei Mao
    Department of Medical Microbiology and Parasitology, College of Medical Science, Zhejiang University, 353 Yanan Road, Hangzhou 310031, Zhejiang Province, China
    World J Gastroenterol 10:977-84. 2004
    ..To clone ureB gene from a clinical isolate of Helicobacter pylori and construct a prokaryotic expression system of the gene and identify immunity of the expressed recombinant protein...
  14. ncbi The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxins
    M S Alphey
    Department of Biochemistry, The Wellcome Trust Biocentre, University of Dundee, Dundee, DD1 5EH, UK
    J Mol Biol 300:903-16. 2000
    ....
  15. ncbi Helicobacter nemestrinae ATCC 49396T is a strain of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989, and Helicobacter nemestrinae Bronsdon et al. 1991 is therefore a junior heterotypic synonym of Helicobacter pylori
    Sebastian Suerbaum
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Germany
    Int J Syst Evol Microbiol 52:437-9. 2002
    ..nemestrinae ATCC 49396T is really a strain of H. pylori and that H. nemestrinae Bronsdon et al. 1991 is a junior heterotypic synonym of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989...
  16. ncbi Functional analysis of the Helicobacter pylori principal sigma subunit of RNA polymerase reveals that the spacer region is important for efficient transcription
    D Beier
    Department of Molecular Biology, Chiron SpA, IRIS Research Institute, Siena, Italy
    Mol Microbiol 30:121-34. 1998
    ..pylori may have evolved a spacer region of the sigma factor to modulate total transcription and to quickly respond to microenvironmental changes...
  17. ncbi Characterization of four members of a multigene family encoding outer membrane proteins of Helicobacter pylori and their potential for vaccination
    B Peck
    Chiron Behring GmbH and Co, Preclinical Research, D 35006 Marburg, Germany
    Microbes Infect 3:171-9. 2001
    ..Using a planar lipid bilayer system the proteins HopV and HopX were shown to form pores with single-channel conductances of 1.4 and 3.0 nS, respectively...
  18. ncbi Structure of Helicobacter pylori catalase, with and without formic acid bound, at 1.6 A resolution
    Peter C Loewen
    Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
    Biochemistry 43:3089-103. 2004
    ..The stability of the formate or formic acid molecule found inside the heme distal pocket has been investigated by calculations based on density functional theory...
  19. ncbi The hppA gene of Helicobacter pylori encodes the class C acid phosphatase precursor
    Renata Godlewska
    Department of Bacterial Genetics, Institute of Microbiology, Warsaw University, Miecznikowa 1, 02 096, Warsaw, Poland
    FEBS Lett 525:39-42. 2002
    ....
  20. ncbi Evaluation of the homologous recombination in Helicobacter pylori
    Slovénie Pyndiah
    INSERM ESPRI 2004, Laboratoire de Bacteriologie, UniversitéVictor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    Helicobacter 10:185-92. 2005
    ..Most strategies for direct mutagenesis of Helicobacter pylori primarily involve genomic DNA cloning which is a time-consuming and expensive technique...
  21. ncbi A novel tRNA-associated locus (trl) from Helicobacter pylori is co-transcribed with tRNA(Gly) and reveals genetic diversity
    W G Dundon
    Department of Microbiology, Trinity College, Dublin 2, Ireland
    Microbiology 145:1289-98. 1999
    ..pylori. Primer extension analysis showed that the trl locus is co-transcribed with tRNA(Gly). Analysis of the region between tRNA(Gly) and tRNA(Leu) in trl-negative isolates revealed additional genetic diversity among these isolates...
  22. ncbi Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase
    A Goodwin
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Mol Microbiol 28:383-93. 1998
    ....
  23. ncbi Role of the rdxA and frxA genes in oxygen-dependent metronidazole resistance of Helicobacter pylori
    Monique M Gerrits
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    J Med Microbiol 53:1123-8. 2004
    ..As there were no significant differences in cell viability between the clinical isolates, it is likely that neither the rdxA nor the frxA gene participates in the reversibility of metronidazole resistance...
  24. ncbi Structural and functional analysis of the riboflavin synthesis genes encoding GTP cyclohydrolase II (ribA), DHBP synthase (ribBA), riboflavin synthase (ribC), and riboflavin deaminase/reductase (ribD) from Helicobacter pylori strain P1
    F Fassbinder
    University of Freiburg, Institute of Medical Microbiology and Hygiene, Department of Microbiology, Freiburg, Germany
    FEMS Microbiol Lett 191:191-7. 2000
    ..coli. Marker exchange mutagenesis of the genes in H. pylori was not successful indicating that riboflavin synthesis is essential for basic metabolic functions of the gastric pathogen...
  25. pmc The major sigma factor (RpoD) from Helicobacter pylori and other gram-negative bacteria shows an enhanced rate of divergence
    J V Solnick
    Department of Internal Medicine, School of Medicine, University of California, Davis 95616, USA
    J Bacteriol 179:6196-200. 1997
    ..This suggests that RpoD from gram-negative bacteria is functionally less constrained than that from gram-positive bacteria...
  26. ncbi Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design
    David A Robinson
    Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    J Med Chem 49:1282-90. 2006
    ....
  27. ncbi Topoisomerase I of Helicobacter pylori: juxtaposition with a flagellin gene (flaB) and functional requirement of a fourth zinc finger motif
    S Suerbaum
    Ruhr Universitat Bochum, Medizinische Mikrobiologie und Immunologie, Bochum, Germany
    Gene 210:151-61. 1998
    ..These data show that TopA proteins can be divided into several classes on the basis of zinc finger motifs and raise the interesting possibility that the H. pylori enzyme has local topological effects focussed on a flagellin gene...
  28. pmc Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori
    S H Phadnis
    Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri 63110
    Infect Immun 62:1557-65. 1994
    ..We further show that in at least one cytotoxin-negative but vacA-positive strain (MO19), there are variations in the length of the vacA gene that could explain the cytotoxin-negative phenotype in this strain...
  29. pmc VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion
    Savvas N Savvides
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    EMBO J 22:1969-80. 2003
    ..Biochemical characterization of mutant forms of HP0525 coupled with electron microscopy and in vivo assays support such hypothesis, and establish the relevance of VirB11s ATPases as drug targets against pathogenic bacteria...
  30. ncbi Acid-induced expression of an LPS-associated gene in Helicobacter pylori
    C C McGowan
    Department of Medicine, Vanderbilt University Medical School, and Department of Veterans Affairs Medical Center, Nashville, TN, USA
    Mol Microbiol 30:19-31. 1998
    ..pylori cells grown at pH 5 compared with pH 7, which suggests that H. pylori may alter its LPS structure in response to acidic pH. This may be an important adaptation facilitating H. pylori colonization of the acidic gastric environment...
  31. ncbi A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori
    Takeshi Okamoto
    Department of Microbiology, Yamaguchi University School of Medicine, Minamikogushi 1 1 1, Ube, Yamaguchi 755 8505, Japan
    J Antimicrob Chemother 50:849-56. 2002
    ..pylori isolated in Korea...
  32. pmc Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori
    Laurent Terradot
    Institute of Structural Molecular Biology, Malet Street, London WC1E 7HX, UK
    Proc Natl Acad Sci U S A 102:4596-601. 2005
    ....
  33. ncbi The class C acid phosphatase of Helicobacter pylori is a 5' nucleotidase
    Thomas J Reilly
    Veterinary Medicine Diagnostic Laboratory, E117 Veterinary Medical Sciences Bldg, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA
    Protein Expr Purif 33:48-56. 2004
    ..The affinity constants for the 5' nucleoside monophosphates were found to be 0.5-1 mM. Results from this study confirm HppA inclusion in the class C acid phosphatases and led to its identification as a 5' nucleotidase...
  34. ncbi Colonization of germ-free transgenic mice with genotyped Helicobacter pylori strains from a case-control study of gastric cancer reveals a correlation between host responses and HsdS components of type I restriction-modification systems
    Britta M Björkholm
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 277:34191-7. 2002
    ..This suggests that the functions of these HsdS homologs may include control of expression of microbial determinants that affect the extent of gastric responses to this potentially virulent pathogen...
  35. ncbi Towards a new therapeutic target: Helicobacter pylori flavodoxin
    Nunilo Cremades
    Biocomputation and Complex Systems Physics Institute, Spain
    Biophys Chem 115:267-76. 2005
    ..It seems thus that low affinity inhibitors of H. pylori flavodoxin can be easily found that, after improvement, may give rise to leads...
  36. ncbi [Relationship between iceA1, iceA2 and babA2 genes of Hp in Xi'an and gastroduodenal diseases]
    Kun Zhuang
    Department of Gastroenterology, Second Affiliated Hospital, Xi an Jiaotong University, Xi an 710004, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23:520-2. 2007
    ..To investigate the distribution of iceA1, iceA2 and babA2 genes of helicobacter pylori (Hp) in Xi'an and analyse the relationship between these genes and gastroduodenal diseases...
  37. ncbi Autoprocessing of Helicobacter pylori gamma-glutamyltranspeptidase leads to the formation of a threonine-threonine catalytic dyad
    Gina Boanca
    Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588 0664, USA
    J Biol Chem 282:534-41. 2007
    ..Substrate docking studies in combination with homology modeling studies of the human homologue reveal additional mechanistic details of enzyme maturation and activation, substrate recognition, and catalysis...
  38. pmc Mutations of the Helicobacter pylori genes rdxA and pbp1 cause resistance against metronidazole and amoxicillin
    R Paul
    Yale University, New Haven, Connecticut 06511, USA
    Antimicrob Agents Chemother 45:962-5. 2001
    ..pylori...
  39. ncbi Helicobacter pylori genes hpcopA and hpcopP constitute a cop operon involved in copper export
    Z Ge
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    FEMS Microbiol Lett 145:181-8. 1996
    ..Our results indicate that the genes for copper import and export are located in separate operons within H. pylori...
  40. ncbi Characterization and inhibitor discovery of one novel malonyl-CoA: acyl carrier protein transacylase (MCAT) from Helicobacter pylori
    Weizhi Liu
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China
    FEBS Lett 580:697-702. 2006
    ..pylori strain, and corytuberine might be used as a potential lead compound in the discovery of the antibacterial agents using HpMCAT as target...
  41. ncbi The effect of galE gene inactivation on lipopolysaccharide profile of Helicobacter pylori
    D H Kwon
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Microbiol 37:144-8. 1998
    ..The LPS profile from the galE-knockout H. pylori strain showed a lower molecular weight than that of the parental strain, indicating the involvement of the galE gene in LPS biosynthesis of H. pylori...
  42. doi Cross-reaction of antibody against Helicobacter pylori urease B with platelet glycoprotein IIIa and its significance in the pathogenesis of immune thrombocytopenic purpura
    Yanyan Bai
    Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China
    Int J Hematol 89:142-9. 2009
    ..These results indicate that H. pylori ureB antibody could cross-react with human platelet GP IIIa and partly inhibit platelet aggregation. UreB may be a crucial component of H. pylori involved in the pathogenesis of a subset of ITP...
  43. ncbi Nucleotide sequence and mutational analysis indicate that two Helicobacter pylori genes encode a P-type ATPase and a cation-binding protein associated with copper transport
    Z Ge
    Department of Medical Microbiology and Infectious Diseases, University of Alberta, Edmonton, Canada
    Mol Microbiol 15:97-106. 1995
    ..The results obtained indicate that ORF1 and ORF2 comprise a cation-transporting system which is associated with copper export out of the H. pylori cells...
  44. ncbi Isolation and characterization of a HpyC1I restriction-modification system in Helicobacter pylori
    Tzu Lung Lin
    Graduate Institute of Microbiology, National Taiwan University, College of Medicine, Taipei 10016, Taiwan
    J Biol Chem 279:11156-62. 2004
    ..In conclusion, we have identified a novel R-M system present in approximately 60% of H. pylori strains. Disruption of this R-M system results in cell elongation and susceptibility to HpyC1I digestion...
  45. pmc Mechanism of metronidazole resistance in Helicobacter pylori: comparison of the rdxA gene sequences in 30 strains
    N M Solcà
    Istituto Cantonale Batteriosierologico, 6904 Lugano, Switzerland
    Antimicrob Agents Chemother 44:2207-10. 2000
    ..Moreover, phylogenetic analysis of the 30 nucleotide sequences did not demonstrate specific clusters associated with the resistance phenotype...
  46. doi A beta-1,4-galactosyltransferase from Helicobacter pylori is an efficient and versatile biocatalyst displaying a novel activity for thioglycoside synthesis
    Darius Jean Namdjou
    Institute for Biological Sciences, National Research Council Canada, 100 Sussex Drive, Ottawa, ON K1A0R6, Canada
    Chembiochem 9:1632-40. 2008
    ..The Gal-beta-1,4-Man linkage is found in the Leishmania species LPG backbone disaccharide repeats and cap, which have been associated with vector binding in Leishmaniasis...
  47. pmc Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan
    Y Ito
    Second Department of Internal Medicine, Fukui Medical School, Yoshida gun, Japan
    J Clin Microbiol 35:1710-4. 1997
    ..These results indicate that the cagA-positive, s1a/m1-type strains are common in Japan, regardless of the vacA phenotype or clinical outcome...
  48. ncbi Supramolecular assembly and acid resistance of Helicobacter pylori urease
    N C Ha
    National Creative Research Initiative Center for Biomolecular Recognition, Department of Life Science and Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk, 790 784, Korea
    Nat Struct Biol 8:505-9. 2001
    ..The structure provides a novel example of a molecular assembly adapted for acid resistance that, together with the low Km value of the enzyme, is likely to enable the organism to inhabit the hostile niche...
  49. ncbi Analysis of hopQ alleles in East Asian and Western strains of Helicobacter pylori
    Ping Cao
    Department of Medicine, Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    FEMS Microbiol Lett 251:37-43. 2005
    ..Geographic variation in the genetic characteristics of H. pylori strains may be a factor contributing to geographic variation in gastric cancer incidence...
  50. ncbi Lewis X biosynthesis in Helicobacter pylori. Molecular cloning of an alpha(1,3)-fucosyltransferase gene
    S L Martin
    Glycobiology Unit, GlaxoWellcome Medicines Research Centre, Stevenage, Herts SG1 2NY, United Kingdom
    J Biol Chem 272:21349-56. 1997
    ..Certain residues in a short segment of the H. pylori protein are completely conserved throughout the alpha(1,3)-Fuc-T family, defining an alpha(1,3)-Fuc-T motif which may be of use in identifying new fucosyltransferase genes...
  51. ncbi Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design
    Han Yu Sun
    Institute of Biochemical Sciences, National Taiwan University, Taipei 10642, Taiwan
    J Biol Chem 282:9973-82. 2007
    ..We propose a catalytic mechanism and a model of polysaccharide binding not only to explain the observed variations in H. pylori lipopolysaccharides, but also to facilitate the development of potent inhibitors...
  52. ncbi Activation of Helicobacter pylori ureA promoter by a hybrid Escherichia coli-H. pylori rpoD gene in E. coli
    M Shirai
    Department of Microbiology, Yamaguchi University School of Medicine, Ube, Japan
    Gene 239:351-9. 1999
    ..coli and H. pylori indicated the existence of a -10 consensus sequence but little conservation of -35 sequences. Instead, the PureA in both H. pylori and E. coli contained an identical heptamer, GTTAATA, in the extended -35 region...
  53. ncbi Helicobacter pylori reinfection is common in Peruvian adults after antibiotic eradication therapy
    Giselle Soto
    Asociacion Benefica PRISMA, Lima, Peru
    J Infect Dis 188:1263-75. 2003
    ..Although eradication with antibiotics was successful, the high rate of reinfection suggests that treatment is unlikely to have a lasting public health effect in this setting...
  54. pmc Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation
    Jianhua Cai
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Graduate School of Chinese Academy of Sciences, China
    Protein Sci 15:2071-81. 2006
    ....
  55. ncbi Molecular genetic basis for the variable expression of Lewis Y antigen in Helicobacter pylori: analysis of the alpha (1,2) fucosyltransferase gene
    G Wang
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    Mol Microbiol 31:1265-74. 1999
    ..Based on these data, we proposed a model for the variable expression of Lewis Y by H. pylori, in which regulation at the level of replication slippage (mutation), transcription and translation of the fucT2 gene may all be involved...
  56. ncbi A new beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Helicobacter pylori: Molecular cloning, enzymatic characterization, and structural modeling
    Weizhi Liu
    Shanghai Institute for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China
    Biochem Biophys Res Commun 333:1078-86. 2005
    ..Our current study is hoped to provide useful information in better understanding the FabZ of H. pylori strain and further supply possible hints in the discovery of anti-bacterial compounds using HpFabZ as target...
  57. pmc Helicobacter pylori glutamine synthetase lacks features associated with transcriptional and posttranslational regulation
    R M Garner
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 66:1839-47. 1998
    ..We conclude that glutamine synthetase is critical for nitrogen assimilation in H. pylori and is active under all physiologic conditions...
  58. ncbi The structures and electronic configuration of compound I intermediates of Helicobacter pylori and Penicillium vitale catalases determined by X-ray crystallography and QM/MM density functional theory calculations
    Mercedes Alfonso-Prieto
    Centre especial de Recerca en Química Teorica, Parc Cientific de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    J Am Chem Soc 129:4193-205. 2007
    ..The findings support the idea that there is a relation between radical migration to the protein and protonation of the oxoferryl bond in catalase...
  59. pmc Conservation, localization and expression of HopZ, a protein involved in adhesion of Helicobacter pylori
    B Peck
    Chiron Behring GmbH and Co, Preclinical Research, PO Box 1630, D 35006 Marburg, Germany
    Nucleic Acids Res 27:3325-33. 1999
    ..Addionally the function of HopZ was investigated in an adhesion assay. The wild-type strain ATCC 43504 adhered to human gastric epithel cells whereas a knockout mutant strain showed significantly reduced binding to the cells...
  60. ncbi Crystal structure of ClpX molecular chaperone from Helicobacter pylori
    Dong Young Kim
    Department of Molecular Cell Biology, Center for Molecular Medicine, SBRI, Sungkyunkwan University School of Medicine, Suwon 440 746, Korea
    J Biol Chem 278:50664-70. 2003
    ..In addition, the nucleotide binding environment provides the structural explanation for the hexameric assembly and the modulation of ATPase activity...
  61. ncbi Crystal structure of alkyl hydroperoxide-reductase (AhpC) from Helicobacter pylori
    Elena Papinutto
    Department of Chemical Sciences, University of Padua, and ICTB, Via Marzolo 1, and Venetian Institute of Molecular Medicine, Via Orus 2, Padua, Italy
    Biochim Biophys Acta 1753:240-6. 2005
    ..Oligomerization properties of AhpC have been also characterized by gel filtration chromatography...
  62. ncbi Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system
    H J Yeo
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell 6:1461-72. 2000
    ..A model is proposed in which HP0525 functions as an inner membrane pore, the closure and opening of which is regulated by ATP binding and ADP release...

Research Grants4

  1. Transcription of H. pylori Genes in the Rhesus Monkey
    JAY SOLNICK; Fiscal Year: 2002
    ..An understanding of the dynamic interaction between host and pathogen may point the way toward critical proteins that may be useful as targets for therapy or vaccine development. ..
  2. Transmission of H. pylori infection in the rhesus monkey
    JAY SOLNICK; Fiscal Year: 2005
    ..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding. ..
  3. Gene expression during H. pylori-host interactions
    JAY SOLNICK; Fiscal Year: 2007
    ..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
  4. Prophylactic and Therapeutic Immunization against H. pylori in Rhesus Macaques
    JAY SOLNICK; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..