Genomes and Genes
Helicobacter pylori 26695
Alias: Helicobacter pylori (strain 26695), Helicobacter pylori KE26695, Helicobacter pylori ATCC 700392, Helicobacter pylori str. 26695, Helicobacter pylori strain 26695
Publications133 found, 100 shown here
- cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factorsS Censini
Immunobiological Research Institute of Siena, Chiron Vaccines, Italy
Proc Natl Acad Sci U S A 93:14648-53. 1996..Thus, we believe the cag region may encode a novel H. pylori secretion system for the export of virulence determinants...
- Purification and characterization of urease from Helicobacter pyloriB E Dunn
Laboratory Service, Denver Veterans Administration Medical Center, Colorado 80220
J Biol Chem 265:9464-9. 1990..pylori proteins at distinguishing sera from persons known either to be infected with H. pylori or not...
- Cloning of the Helicobacter pylori recA gene and functional characterization of its productW Schmitt
Max Planck Institut fur Biologie, Abteilung Infektionsbiologie, Tubingen, Germany
Mol Gen Genet 248:563-72. 1995..pylori which is crucial for its function. The potential modification seems not to occur when the protein is produced in E. coli, giving rise to a smaller but inactive protein...
- Isolation of the Helicobacter pylori recA gene and involvement of the recA region in resistance to low pHS A Thompson
Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
Infect Immun 63:2185-93. 1995..This difference occurred in the presence or absence of urea, implying the involvement of a gene in the recA region in an acid resistance mechanism distinct from that mediated by urease...
- Characterization of a Helicobacter pylori neutrophil-activating proteinD J Evans
Bacterial Enteropathogens Laboratory, Veterans Affairs Medical Center, Houston, Texas 77030, USA
Infect Immun 63:2213-20. 1995..pylori isolates tested; however, there was considerable strain variation in the level of expression of HP-NAP activity in vitro. HP-NAP could play an important role in the gastric inflammatory response to H. pylori infection...
- Identification of four new prokaryotic bacterioferritins, from Helicobacter pylori, Anabaena variabilis, Bacillus subtilis and Treponema pallidum, by analysis of gene sequencesD J Evans
Department of Medicine, Baylor College of Medicine, Houston, TX 77030
Gene 153:123-7. 1995..Genes Dev. 6 (1992) 2646-2654] is clearly a HPNAP/Bfr homologue, a significant part of its Frx center is missing. It is unlikely that the intracellular function of HPNAP is related to its ability to activate neutrophils...
- A urease-negative mutant of Helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomachM Tsuda
Department of Microbiology, Yamaguchi University School of Medicine, Ube, Japan
Infect Immun 62:3586-9. 1994..There was no gastritis in the HPT73-challenged stomachs, and we could not recover H. pylori from them. These results indicated that H. pylori urease is essential for colonizing the nude mouse stomach...
- Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported proteinW Schmitt
Max Planck Institut fur Biologie, Abteilung Infektionsbiologie, Tubingen, Germany
Mol Microbiol 12:307-19. 1994....
- Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strainsT L Cover
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605
J Biol Chem 269:10566-73. 1994..8% amino acid identity with the corresponding region from tox+ strain 60190. Thus, sequence divergence in vacA genes may explain the lack of functionally active cytotoxin production by some H. pylori isolates...
- Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pyloriS H Phadnis
Department of Molecular Microbiology, Washington University Medical School, St Louis, Missouri 63110
Infect Immun 62:1557-65. 1994..We further show that in at least one cytotoxin-negative but vacA-positive strain (MO19), there are variations in the length of the vacA gene that could explain the cytotoxin-negative phenotype in this strain...
- High-level genetic diversity in the vapD chromosomal region of Helicobacter pyloriP Cao
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605, USA
J Bacteriol 179:2852-6. 1997..5-kb DNA segments, which were both unrelated to vapD. The presence of vapD was not associated with any specific family of vacA alleles. These findings are consistent with a recombinational population structure for H. pylori...
- Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retaggingD Ilver
Department of Microbiology, Umea University, SE 901 87 Umea, Sweden
Science 279:373-7. 1998..pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori...
- Neutrophil-activating protein mediates adhesion of Helicobacter pylori to sulfated carbohydrates on high-molecular-weight salivary mucinF Namavar
Department of Medical Microbiology, Medical School, Vrije Universiteit, Amsterdam, The Netherlands
Infect Immun 66:444-7. 1998..Sequence analysis of the protein proved that it was identical to the N-terminal amino acid sequence of neutrophil-activating protein. Moreover, this adhesin was able to bind to Lewis x blood group antigen...
- Cloning and characterization of the fur gene from Helicobacter pyloriS Bereswill
Institute of Medical Microbiology and Hygiene, Department of Microbiology and Hygiene, Freiburg, Germany
FEMS Microbiol Lett 159:193-200. 1998..Comparison of Fur from H. pylori strain NCTC11638 with the recently published genomic DNA sequence of another strain (26695) confirmed the identity of the fur homologue and revealed that the fur locus is highly conserved in both strains...
- Analyses of the cag pathogenicity island of Helicobacter pyloriN S Akopyants
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
Mol Microbiol 28:37-53. 1998..Our results are discussed in terms of how cag-encoded proteins might help trigger the damaging inflammatory responses in the gastric epithelium and possible contributions of DNA rearrangements to genome evolution...
- Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductaseA Goodwin
Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Mol Microbiol 28:383-93. 1998....
- Isolation of Helicobacter pylori genes that modulate urease activityD J McGee
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Bacteriol 181:2477-84. 1999..Thus, flagellar biosynthesis and urease activity may be linked in H. pylori. These results suggest that H. pylori genes may modulate urease activity...
- The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structureF Tonello
Centro CNR Biomembrane and Dipartimento di Scienze Biomediche, Universita di Padova, I 35121, Italy
Mol Microbiol 34:238-46. 1999..We therefore conclude that HP-NAP is an unusual, small, ferritin that folds into a four-helix bundle that oligomerizes into dodecamers with a central hole capable of binding up to 500 iron atoms per oligomer...
- A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonizationD L Weeks
VA Greater Los Angeles Healthcare System and Department of Physiology, University of California, Los Angeles, CA 90073, USA
Science 287:482-5. 2000..UreI functions as a H+-gated urea channel regulating cytoplasmic urease that is essential for gastric survival and colonization...
- A novel 3-methyladenine DNA glycosylase from Helicobacter pylori defines a new class within the endonuclease III family of base excision repair glycosylasesE J O'Rourke
Departement de Radiobiologie et Radiopathologie, Commissariat a l Energie Atomique, UMR217 CEA CNRS, BP6, 92265 Fontenay aux Roses, France
J Biol Chem 275:20077-83. 2000..MagIII is thus a novel bacterial member of the endonuclease III family, which displays biochemical properties not described for any of the members of this group until now...
- Identification of the urease operon in Helicobacter pylori and its control by mRNA decay in response to pHJ K Akada
Department of Microbiology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
Mol Microbiol 36:1071-84. 2000..We are tempted to speculate that the ureE" transcript present in acidic pH may contribute to produce an active product that can proceed the nickel incorporation to the active centre, the final step of urease biosynthesis...
- Requirement of nickel metabolism proteins HypA and HypB for full activity of both hydrogenase and urease in Helicobacter pyloriJ W Olson
Department of Microbiology, 813 Biological Sciences Building, University of Georgia, Athens, GA 30602, USA
Mol Microbiol 39:176-82. 2001....
- The protein-protein interaction map of Helicobacter pyloriJ C Rain
Hybrigenics SA, Paris, France
Nature 409:211-5. 2001..6% of the proteome. The determination of a reliability score for every single protein-protein interaction and the identification of the actual interacting domains permitted the assignment of unannotated proteins to biological pathways...
- Nickel-responsive induction of urease expression in Helicobacter pylori is mediated at the transcriptional levelA H van Vliet
Department of Medical Microbiology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
Infect Immun 69:4891-7. 2001..These data demonstrate nickel-responsive regulation of H. pylori urease, a phenomenon likely to be of importance during the colonization and persistence of H. pylori in the gastric mucosa...
- The Helicobacter pylori UreI protein: role in adaptation to acidity and identification of residues essential for its activity and for acid activationS Bury-Moné
Institut Pasteur, Unité de Pathogénie Bactérienne des Muqueuses, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Mol Microbiol 42:1021-34. 2001..UreI behaves like a novel type of urea transporter, and the identification of residues essential for its function in H. pylori provides new insight into the unusual molecular mechanism of low pH activation...
- Recombination and mutation during long-term gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size, and minimal ageD Falush
Max Planck Institut für Infektionsbiologie, Schumannstrasse 21 22, 10117 Berlin, Germany
Proc Natl Acad Sci U S A 98:15056-61. 2001..Thus, the panmictic population structure of H. pylori results from very frequent recombination during mixed colonization by unrelated strains...
- Differential regulation of amidase- and formamidase-mediated ammonia production by the Helicobacter pylori fur repressorArnoud H M van Vliet
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
J Biol Chem 278:9052-7. 2003..These roles of Fur in regulation of the H. pylori amidases suggest that the H. pylori Fur regulator may have acquired extra functions to compensate for the absence of other regulatory systems...
- Tracing clonality of Helicobacter pylori infecting family members from analysis of DNA sequences of three housekeeping genes (ureI, atpA and ahpC), deduced amino acid sequences, and pathogenicity-associated markers (cagA and vacA)Robert J Owen
Helicobacter Reference Unit, Laboratory of Enteric Pathogens, Health Protection Agency, London, UK
J Med Microbiol 52:515-24. 2003..Analysis of these three housekeeping genes provides unique evidence for precise tracing of clonal descent in isolates of H. pylori in family groups...
- Comparative analysis of the complete cag pathogenicity island sequence in four Helicobacter pylori isolatesAnna Blomstergren
Department of Biotechnology, Royal Institute of Technology, Alba Nova University Center, Roslagstullsbacken 21, S 106 91 Stockholm, Sweden
Gene 328:85-93. 2004..Finally, a novel gene was identified in the cag PAI in three of the sequenced strains at the position of HP0521. This gene, HP0521B, is present in approximately half of Swedish H. pylori isolates...
- Construction of prokaryotic expression system of ureB gene from a clinical Helicobacter pylori strain and identification of the recombinant protein immunityYa Fei Mao
Department of Medical Microbiology and Parasitology, College of Medical Science, Zhejiang University, 353 Yanan Road, Hangzhou 310031, Zhejiang Province, China
World J Gastroenterol 10:977-84. 2004..To clone ureB gene from a clinical isolate of Helicobacter pylori and construct a prokaryotic expression system of the gene and identify immunity of the expressed recombinant protein...
- Evidence for the active role of a novel nuclease from Helicobacter pylori in the horizontal transfer of genetic informationEyleen J O'Rourke
Fundacion Instituto Leloir, University of Buenos Aires and CONICET, Av Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina
J Bacteriol 186:2586-93. 2004....
- Distinct diversity of the cag pathogenicity island among Helicobacter pylori strains in JapanTakeshi Azuma
Second Department of Internal Medicine, Faculty of Medical Science, University of Fukui Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
J Clin Microbiol 42:2508-17. 2004..These results suggest that a distinct diversity of the cag PAI of H. pylori is present among Japanese strains and that this diversity may be involved in the development of atrophic gastritis and may increase the risk for gastric cancer...
- New tumor necrosis factor-alpha-inducing protein released from Helicobacter pylori for gastric cancer progressionMasami Suganuma
Saitama Cancer Center, Ina Kitaadachi gun, 362 0806 Saitama, Japan
J Cancer Res Clin Oncol 131:305-13. 2005..To investigate the association between Helicobacter pylori infection and its inflammatory reaction in gastritis, gastric ulcer, and gastric cancer, a new tumor necrosis factor-alpha (TNF-alpha)-inducing protein of H. pylori was studied...
- Suppression of homologous and homeologous recombination by the bacterial MutS2 proteinA Viviana Pinto
Departement de Radiobiologie et Radiopathologie, UMR217 CNRS CEA, Commissariat a l Energie Atomique, BP 6, F 92265 Fontenay aux Roses, France
Mol Cell 17:113-20. 2005..Finally, we show that HpMutS2 inhibits DNA strand exchange reactions in vitro. Thus, MutS2 proteins are candidates for controlling recombination and therefore genetic diversity in bacteria...
- Iron-responsive regulation of the Helicobacter pylori iron-cofactored superoxide dismutase SodB is mediated by FurFlorian D Ernst
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dijkzigt L 4, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
J Bacteriol 187:3687-92. 2005..In conclusion, H. pylori Fur is a versatile regulator involved in many pathways essential for gastric colonization, including superoxide stress defense...
- Cloning and characterization of spermidine synthase and its implication in polyamine biosynthesis in Helicobacter pylori strain 26695Mon Juan Lee
Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan
Protein Expr Purif 43:140-8. 2005The HP0832 (speE) gene of Helicobacter pylori strain 26695 codes for a putative spermidine synthase, which belongs to the polyamine biosynthetic pathway...
- Solution structure of conserved hypothetical protein HP0894 from Helicobacter pyloriKyung Doo Han
National Laboratory of Membrane Protein Structure, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea
Proteins 61:1114-6. 2005
- Requirement of histidine kinases HP0165 and HP1364 for acid resistance in Helicobacter pyloriJohn T Loh
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Infect Immun 74:3052-9. 2006..These results indicate that intact HP0165 and HP1364 histidine kinases are required for acid resistance in H. pylori...
- Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activityNoboru Ishiyama
Department of Biochemistry and Department of Microbiology and Immunology, McGill University, Montreal, Quebec
J Biol Chem 281:24489-95. 2006..Guided by evidence from site-directed mutagenesis and computational simulations, a three-step reaction mechanism is proposed that involves Lys-133 functioning as both a catalytic acid and base...
- Helicobacter pylori genes involved in avoidance of mutations induced by 8-oxoguanineAurelie Mathieu
Departement de Radiobiologie et Radiopathologie, UMR 217 CNRS CEA, Commissariat a l Energie Atomique, 18 route du Panorama, F 92265 Fontenay aux Roses, France
J Bacteriol 188:7464-9. 2006..pylori cell extracts. Disruption of HP1526, a putative xth homolog, confirmed that this gene is responsible for the AP endonuclease activity. The lack of evidence for an Fpg/OGG1 functional homolog is also discussed...
- Unveiling novel RecO distant orthologues involved in homologous recombinationStéphanie Marsin
CEA, Institut de Radiobiologie Cellulaire et Moleculaire, UMR217 CNRS CEA, Fontenay aux Roses, France
PLoS Genet 4:e1000146. 2008..These results provide insight into the mechanisms that this successful pathogen uses to generate genetic diversity and adapt to changing environments and new hosts...
- The pH-responsive regulon of HP0244 (FlgS), the cytoplasmic histidine kinase of Helicobacter pyloriYi Wen
The Membrane Biology Laboratory, Department of Physiology, David Geffen School of Medicine at UCLA, California 90073, USA
J Bacteriol 191:449-60. 2009....
- Crystal structure of the TNF-alpha-Inducing protein (Tipalpha) from Helicobacter pylori: Insights into Its DNA-binding activityJun Young Jang
Department of Chemistry, Seoul National University, Korea
J Mol Biol 392:191-7. 2009..A positively charged surface patch formed across the two monomers of the Tipalpha dimer by the loop between helices alpha1 and alpha2 may be important in DNA binding...
- Structural basis for the Helicobacter pylori-carcinogenic TNF-alpha-inducing proteinHideaki Tsuge
Institute for Health Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
Biochem Biophys Res Commun 388:193-8. 2009..del-Tipalpha's unique mode of dimer formation provides important insight into protein-protein interactions and into the mechanism underlying the carcinogenicity of H. pylori infection...
- Characterization of an N6 adenine methyltransferase from Helicobacter pylori strain 26695 which methylates adjacent adenines on the same strandRitesh Kumar
Department of Biochemistry, Indian Institute of Science, Bangalore, India
FEBS J 277:1666-83. 2010..pylori. Collectively, these findings provide impetus for exploring the role(s) of this conserved DNA methyltransferase in the cellular processes of H. pylori...
- Genetic dissection of Helicobacter pylori AddAB role in homologous recombinationStéphanie Marsin
CEA, Institut de Radiobiologie Cellulaire et Moleculaire, UMR217 CNRS CEA, Fontenay aux Roses, France
FEMS Microbiol Lett 311:44-50. 2010..However, neither of these complexes participates in the RecA-dependent process of transformation of these naturally competent bacteria...
- Purification of Helicobacter pylori superoxide dismutase and cloning and sequencing of the geneC Spiegelhalder
Institute for Medical Microbiology and Hygiene, Freiburg, Germany
Infect Immun 61:5315-25. 1993..There was no leader sequence detectable. Cloning of the H. pylori SOD gene is one of the prerequisites to investigation of its pathophysiological role in the defense against antimicrobial mechanisms of polymorphonuclear granulocytes...
- Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cellsM K Tummuru
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2605, USA
Mol Microbiol 18:867-76. 1995....
- Carbohydrate binding specificity of the neutrophil-activating protein of Helicobacter pyloriS Teneberg
Department of Medical Biochemistry, Goteborg University, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
J Biol Chem 272:19067-71. 1997..pylori preferentially recognizes glycoconjugates with a terminally unsubstituted NeuAcalpha3Galbeta4GlcNAcbeta3Galbeta4GlcNAcbeta sequence...
- The Helicobacter pylori UreI protein is not involved in urease activity but is essential for bacterial survival in vivoS Skouloubris
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 75724 Paris Cedex 15, France
Infect Immun 66:4517-21. 1998..2) in the presence of 10 mM urea. UreI is predicted to be an integral membrane protein and may therefore be involved in a transport process essential for H. pylori survival in vivo...
- The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding proteinLucas Luthy
Biochemisches Institut, Universitat Zurich, Winterthurer Strasse 190, 8057 Zurich, Switzerland
J Biol Chem 277:10187-93. 2002..The putative penicillin binding site is located in an amphipathic groove on the concave side of the molecule...
- UvrD helicase suppresses recombination and DNA damage-induced deletionsJosephine Kang
Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Bacteriol 188:5450-9. 2006..pylori that face high-level genotoxic stress in vivo...
- Surface localization of Helicobacter pylori urease and a heat shock protein homolog requires bacterial autolysisS H Phadnis
Department of Pathology, Medical College of Wisconsin, Milwaukee, USA
Infect Immun 64:905-12. 1996..pylori is an important phenomenon to recognize since it likely exerts significant effects on the behavior of H. pylori. Furthermore, the surface properties of H. pylori must be unique in promoting adsorption of cytoplasmic proteins...
- The AmiE aliphatic amidase and AmiF formamidase of Helicobacter pylori: natural evolution of two enzyme paraloguesS Skouloubris
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15
Mol Microbiol 40:596-609. 2001..pylori paralogous amidases have evolved to achieve enzymatic specialization after ancestral gene duplication; and (ii) the production of these enzymes is regulated to maintain intracellular nitrogen balance in H. pylori...
- Molecular signatures (unique proteins and conserved indels) that are specific for the epsilon proteobacteria (Campylobacterales)Radhey S Gupta
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, L8N 3Z5, Canada
BMC Genomics 7:167. 2006..The epsilon proteobacteria, which include many important human pathogens, are presently recognized solely on the basis of their branching in rRNA trees. No unique molecular or biochemical characteristics specific for this group are known...
- Effect of methanolic extract of Terminalia arjuna against Helicobacter pylori 26695 lipopolysaccharide-induced gastric ulcer in ratsRethinam Sundaresan Devi
Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu, India
J Pharm Pharmacol 60:505-14. 2008..The anti-ulcer effect of TA may reflect its ability to combat factors that damage the gastric mucosa, and to protect the mucosal defensive factors...
- Biochemical and pathophysiological characterization of Helicobacter pylori asparaginaseKeigo Shibayama
Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan
Microbiol Immunol 55:408-17. 2011Asparaginase was purified from Helicobacter pylori 26695 and its pathophysiological role explored. The K(m) value of asparagine was 9.75 ± 1.81 μM at pH 7.0, and the optimum pH range was broad and around a neutral pH. H...
- Contribution of dppA to urease activity in Helicobacter pylori 26695Gregg S Davis
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109 0620, USA
Helicobacter 10:416-23. 2005..The predicted Dpp polypeptides DppA, DppC, and DppD of H. pylori share approximately 40%, 53%, and 56% amino acid sequence identity with their respective E. coli homologs...
- Helicobacter pylori proteomics by 2-DE/MS, 1-DE-LC/MS and functional data miningPeter R Jungblut
Core Facility Protein Analysis, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
Proteomics 10:182-93. 2010With its predicted proteome of 1550 proteins (data set Etalon) Helicobacter pylori 26695 represents a perfect model system of medium complexity for investigating basic questions in proteomics...
- Effects of a HP0859 (rfaD) knockout mutation on lipopolysaccharide structure of Helicobacter pylori 26695 and the bacterial adhesion on AGS cellsPo Chun Chang
Institute of Molecular Medicine and Department of Life Science, National Tsing Hua University, 101, Sec 2, Kuang Fu Rd, Hsinchu 30013, Taiwan, ROC
Biochem Biophys Res Commun 405:497-502. 2011..In conclusion, we demonstrate that HP0859 codes for a protein essential for the LPS inner core biosynthesis in H. pylori and an intact LPS structure contributes to the adherence ability of this bacterium...
- Systematic identification of selective essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesisA F Chalker
Department of Anti Infective Research, SmithKline Beecham Pharmaceuticals, Collegeville, Pennsylvania 19426, USA
J Bacteriol 183:1259-68. 2001A comparative genomic approach was used to identify Helicobacter pylori 26695 open reading frames (ORFs) which are conserved in H. pylori J99 but highly diverged in other eubacteria...
- The complete genome sequence of the gastric pathogen Helicobacter pyloriJ F Tomb
Institute for Genomic Research, Rockville, Maryland 20850, USA
Nature 388:539-47. 1997..pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH...
- Backbone 1H, 15N, and 13C resonance assignments and secondary-structure of the conserved hypothetical protein HP0892 of Helicobacter pyloriKyung Doo Han
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
Mol Cells 25:138-41. 2008HP0892 (SwissProt/TrEMBL ID O25552) is a 90-residue conserved hypothetical protein from Helicobacter pylori strain 26695, with a calculated pI of 9.38 and a molecular mass of 10.41 kDa...
- Genome-scale metabolic model of Helicobacter pylori 26695Christophe H Schilling
Genomatica, Inc, San Diego, California 92121, USA
J Bacteriol 184:4582-93. 2002A genome-scale metabolic model of Helicobacter pylori 26695 was constructed from genome sequence annotation, biochemical, and physiological data...
- Helicobacter pylori and its genome: lessons from the treasure mapD E Taylor
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
Can J Gastroenterol 13:218-23. 1999The availability of the complete genome sequence of Helicobacter pylori 26695 has opened new avenues for research in the molecular biology of this gastric pathogen...
- Analysis of automatically generated peptide mass fingerprints of cellular proteins and antigens from Helicobacter pylori 26695 separated by two-dimensional electrophoresisAlexander Krah
Core Facility for Protein Analysis, Department of Molecular Biology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
Mol Cell Proteomics 2:1271-83. 2003..Additionally, the protein species distribution of the known antigen GroEL was investigated, dimers of the protein alkyl hydroperoxide reductase were found, and the fragmentation of gamma-glutamyltranspeptidase was demonstrated...
- Relationship of IL-8 production and the CagA status in AGS cells infected with Helicobacter pylori exposed to low pH and activating transcription factor 3 (ATF3)Yanan Zhang
Department of Clinical Laboratory Medicine, Kochi University School of Medicine, Oko cho, Nankoku City, Japan
Microbiol Res 164:180-90. 2009..ATF3 transcripts peaked late phase by wild-type, however, induced in two peaks early and late phases by cagA-disrupted mutants, indicating that different CagA-type proteins altered ATF3 induction in the infected cells...
- Characterization of a waaF mutant of Helicobacter pylori strain 26695 provides evidence that an extended lipopolysaccharide structure has a limited role in the invasion of gastric cancer cellsVandana Chandan
Institute for Biological Sciences, National Research Council of Canada, Ottawa, ON, K1A 0R6, Canada
Biochem Cell Biol 85:582-90. 2007An LD-heptosyltransferase gene, HP1191 (waaF), involved in biosynthesis of the inner-core region of Helicobacter pylori strain 26695 lipopolysaccharide (LPS), has been cloned and its function established by complementation of Salmonella ..
- Functional identification of toxin-antitoxin molecules from Helicobacter pylori 26695 and structural elucidation of the molecular interactionsKyung Doo Han
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Kwanak gu, Seoul 151 742, Korea
J Biol Chem 286:4842-53. 2011..Taken together, it is concluded that the HP0894-HP0895 protein couple is a TA system in H. pylori, where HP0894 is a toxin with an RNase function, whereas HP0895 is an antitoxin functioning by binding to both the toxin and DNA...
- Finding pathogenicity islands and gene transfer events in genome dataP Lio
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Bioinformatics 16:932-40. 2000..Current methods for genome analysis choose a window size and compute a chi(2) statistics of the average value for each window with respect to the whole genome...
- Backbone 1H, 15N, and 13C resonance assignment and secondary structure prediction of HP0495 from Helicobacter pyloriMin Duk Seo
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, San 56 1, Shillim Dong, Gwanak Gu, Seoul 151 742, Republic of Korea
J Biochem Mol Biol 40:839-43. 2007HP0495 (Swiss-Prot ID; Y495_HELPY) is an 86-residue hypothetical protein from Helicobacter pylori strain 26695. The function of HP0495 cannot be identified based on sequence homology, and HP0495 is included in a fairly unique sequence ..
- Structure of a nickel chaperone, HypA, from Helicobacter pylori reveals two distinct metal binding sitesWei Xia
Department of Chemistry and Open Laboratory of Chemical Biology, University of Hong Kong, Pokfulam, Hong Kong, People s Republic of China
J Am Chem Soc 131:10031-40. 2009..Low coordination number of Ni(2+) may allow the metal to be readily transferred to its downstream receptors. Our studies may shed light on how the metallochaperone exerts its functions in intracellular nickel delivery...
- Molecular characterization of a flagellar export locus of Helicobacter pyloriS Porwollik
Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
Infect Immun 67:2060-70. 1999..pylori 26695, was reduced in both the virB11 mutant and the fliI mutant, suggesting related functions of the virulence factor export protein (VirB11) and the flagellar export component (FliI)...
- Molecular cloning and characterization of a new peptide deformylase from human pathogenic bacterium Helicobacter pyloriCong Han
Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China
Biochem Biophys Res Commun 319:1292-8. 2004..This present work thereby supplies a potential platform that facilitates the discovery of novel HpPDF inhibitors and further of possible antimicrobial agents against H. pylori...
- Helicobacter pylori thioredoxin is an arginase chaperone and guardian against oxidative and nitrosative stressesDavid J McGee
Department of Microbiology and Immunology and Biological Sciences, University of South Alabama, Mobile, AL, USA
J Biol Chem 281:3290-6. 2006..Trx1 and arginase equip H. pylori with a "renox guardian" to overcome abundant nitrosative and oxidative stresses encountered during the persistence of the bacterium in the hostile gastric environment...
- Kinetic and structural properties of triosephosphate isomerase from Helicobacter pyloriChen Hsi Chu
Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 30013, Taiwan, Republic of China
Proteins 71:396-406. 2008..The results suggest that this conserved salt bridge is not essential for the enzymatic activity of HpTIM; however, it might contribute to the conformational stability of HpTIM...
- Crystal structure of Helicobacter pylori MinE, a cell division topological specificity factorGil Bu Kang
School of Life Science, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Korea
Mol Microbiol 76:1222-31. 2010..We therefore redefine the functional domain of MinE and propose that a multimeric filamentous structure is formed through anti-parallel beta-strand interactions...
- Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthasesChih Jung Kuo
Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan
J Biomed Biotechnol 2008:841312. 2008..pylori without killing the intestinal E. coli...
- Re-annotation of the genome sequence of Helicobacter pylori 26695Tiago Resende
IBB Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, University of Minho, Portugal
J Integr Bioinform 10:233. 2013..This information provides relevant biological information for the scientific community dealing with this organism and can be used as the basis for a new metabolic model reconstruction. ..
- Production of a conserved adhesin by the human gastroduodenal pathogen Helicobacter pyloriP Doig
Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada
J Bacteriol 174:2539-47. 1992..pylori and eucaryotic cells. This ability to act as an adhesin may make this protein an important virulence factor for H. pylori and hence a potential target for a vaccine and therapy...
- Purification of recombinant Helicobacter pylori urease apoenzyme encoded by ureA and ureBL T Hu
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201
Infect Immun 60:2657-66. 1992..coli and that these genes alone are sufficient for the synthesis and assembly of the native size enzyme. Genes downstream of ureB, however, are necessary for production of a catalytically active urease...
- Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagellaM Kostrzynska
Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada
J Bacteriol 173:937-46. 1991..pylori, suggesting that this serological test could be a useful addition to those currently employed in the rapid identification of this important pathogen...
- The putative neuraminyllactose-binding hemagglutinin HpaA of Helicobacter pylori CCUG 17874 is a lipoproteinP W O'Toole
Astra Arcus AB, Sodertalje, Sweden
J Bacteriol 177:6049-57. 1995..The data collectively suggest that HpaA is a nonessential lipoprotein internal to the H. pylori cell and that it is not involved in adhesion...
- The Hsp60 protein of Helicobacter pylori: structure and immune response in patients with gastroduodenal diseasesG Macchia
IRIS Immunobiological Research Institute Siena, Italy
Mol Microbiol 9:645-52. 1993..pylori Hsp60 antibodies, potentially cross-reactivity between human Hsp60 and a rabbit antiserum against H. pylori Hsp60 suggest that a role of this protein in gastroduodenal diseases is possible...
- Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchangeS Suerbaum
Unité des Entérobactéries, Institut Pasteur, INSERM U199, F 75724 Paris, France
J Bacteriol 175:3278-88. 1993..Both mutations selectively abolished the expression of the targeted gene without affecting the synthesis of the other flagellin molecule. Whereas flaA mutants were completely nonmotile, flaB mutants retained motility...
- Topoisomerase I of Helicobacter pylori: juxtaposition with a flagellin gene (flaB) and functional requirement of a fourth zinc finger motifS Suerbaum
Ruhr Universitat Bochum, Medizinische Mikrobiologie und Immunologie, Bochum, Germany
Gene 210:151-61. 1998..These data show that TopA proteins can be divided into several classes on the basis of zinc finger motifs and raise the interesting possibility that the H. pylori enzyme has local topological effects focussed on a flagellin gene...
- Helicobacter pylori glutamine synthetase lacks features associated with transcriptional and posttranslational regulationR M Garner
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
Infect Immun 66:1839-47. 1998..We conclude that glutamine synthetase is critical for nitrogen assimilation in H. pylori and is active under all physiologic conditions...
- Hemolytic properties and riboflavin synthesis of Helicobacter pylori: cloning and functional characterization of the ribA gene encoding GTP-cyclohydrolase II that confers hemolytic activity to Escherichia coliS Bereswill
Institute of Medical Microbiology, Department of Microbiology and Hygiene, Freiburg, Germany
Med Microbiol Immunol 186:177-87. 1998..This analysis revealed that microdiversity exists within the DNA region upstream from ribA, which was further confirmed by nucleotide sequence analysis...
- Acid-induced expression of an LPS-associated gene in Helicobacter pyloriC C McGowan
Department of Medicine, Vanderbilt University Medical School, and Department of Veterans Affairs Medical Center, Nashville, TN, USA
Mol Microbiol 30:19-31. 1998..pylori cells grown at pH 5 compared with pH 7, which suggests that H. pylori may alter its LPS structure in response to acidic pH. This may be an important adaptation facilitating H. pylori colonization of the acidic gastric environment...
- Sequence analysis and clinical significance of the iceA gene from Helicobacter pylori strains in JapanY Ito
Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan
J Clin Microbiol 38:483-8. 2000..We showed that iceA1 sequence variations may be useful tools for analysis of the population genetics of H. pylori...
- Autophosphorylation of phosphoglucosamine mutase from Escherichia coliL Jolly
Laboratoire des Enveloppes Bactériennes et Antibiotiques, Centre National de la Recherche Scientifique, Universite Paris Sud, 91405 Orsay, France
J Bacteriol 182:1280-5. 2000..coli GlmM...
- Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cellA Covacci
Immunobiological Research Institute of Siena IRIS, Chiron S p A, 53100 Siena, Italy
J Exp Med 191:587-92. 2000
- Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high-affinity ferrous iron transporterJ Velayudhan
Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
Mol Microbiol 37:274-86. 2000..pylori Fe acquisition. feoB mutants were unable to colonize the gastric mucosa of mice, indicating that FeoB makes an important contribution to Fe acquisition by H. pylori in the low-pH, low-O2 environment of the stomach...
- Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion systemH J Yeo
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA
Mol Cell 6:1461-72. 2000..A model is proposed in which HP0525 functions as an inner membrane pore, the closure and opening of which is regulated by ATP binding and ADP release...
- Helicobacter nemestrinae ATCC 49396T is a strain of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989, and Helicobacter nemestrinae Bronsdon et al. 1991 is therefore a junior heterotypic synonym of Helicobacter pyloriSebastian Suerbaum
Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Germany
Int J Syst Evol Microbiol 52:437-9. 2002..nemestrinae ATCC 49396T is really a strain of H. pylori and that H. nemestrinae Bronsdon et al. 1991 is a junior heterotypic synonym of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989...
- VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretionSavvas N Savvides
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
EMBO J 22:1969-80. 2003..Biochemical characterization of mutant forms of HP0525 coupled with electron microscopy and in vivo assays support such hypothesis, and establish the relevance of VirB11s ATPases as drug targets against pathogenic bacteria...
- Roles of conserved nucleotide-binding domains in accessory proteins, HypB and UreG, in the maturation of nickel-enzymes required for efficient Helicobacter pylori colonizationNalini Mehta
Department of Microbiology, University of Georgia, 527 Biological Sciences Building, Athens, GA 30602, USA
Microb Pathog 35:229-34. 2003..Expression of the UreA and UreB subunits of urease in both the mutants was also normal. Purified UreG parental and mutant (Lys14 to Ala14) proteins had molecular masses of 27 kDa, but possessed negligible GTP hydrolyzing activity...
- The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a TLR4- and apoptosis signal-regulating kinase 1-dependent mannerChaitali Basak
Department of Chemistry, Bose Institute, Kolkata, India
J Immunol 174:5672-80. 2005....
- Molecular cloning and functional expression of a novel Helicobacter pylori alpha-1,4 fucosyltransferaseSaid Rabbani
Institute of Molecular Pharmacy, Pharmacenter, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
Glycobiology 15:1076-83. 2005..Additionally, the enzyme possesses a broad tolerance toward nonnatural Type I acceptor substrate analogs and therefore represents a valuable tool for the chemoenzymatic synthesis of Lewis A, sialyl Lewis A as well as mimetics thereof...
- Expression and characterization of a histidine-rich protein, Hpn: potential for Ni2+ storage in Helicobacter pyloriRuiguang Ge
Department of Chemistry and Open Laboratory of Chemical Biology, The University of Hong Kong, Pokfulam, Hong Kong, People s Republic of China
Biochem J 393:285-93. 2006..pylori hpn-deletion mutant strains. Hpn may potentially serve multiple roles inside the bacterium: storage of Ni2+ ions in a 'reservoir'; donation of Ni2+ to other proteins; and detoxification via sequestration of excess Ni2+...
- Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pyloriKwang H Lee
Department of Chemistry and Bio Molecular Informatics Center, Konkuk University, Seoul 143 701, Korea
Biochem J 394:105-14. 2006..Because anal-3 shows high selectivity towards bacterial and fungal cells, it may provide an avenue for the development of new antibiotics...
- Transcription of H. pylori Genes in the Rhesus MonkeyJAY SOLNICK; Fiscal Year: 2002..An understanding of the dynamic interaction between host and pathogen may point the way toward critical proteins that may be useful as targets for therapy or vaccine development. ..
- Metabolic Drug Targeting in Haemophilus influenzeCHRISTOPHE SCHILLING; Fiscal Year: 2004..influenzae infections; 5) and enhanced validation of existing targets in H. influenzae. ..
- Transmission of H. pylori infection in the rhesus monkeyJAY SOLNICK; Fiscal Year: 2005..pylori; 3) Determine the effects of H. pylori infection on the acquisition of Campylobacter jejuni; and 4) Determine the effects of the CagA pathogenicity island on colonization and shedding. ..
- Gene expression during H. pylori-host interactionsJAY SOLNICK; Fiscal Year: 2007..These studies will provide a functional genomic understanding of the H. pylori host-pathogen relationship that may have implications for novel treatment or vaccine strategies. ..
- Prophylactic and Therapeutic Immunization against H. pylori in Rhesus MacaquesJAY SOLNICK; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- H. Pylory factors associated with peptic ulcer diseaseTIMOTHY COVER; Fiscal Year: 2006..pylori factors that help to determine clinical outcome, and ultimately, may lead to advances in the treatment or prevention of H. pylori-associated human diseases. [unreadable] [unreadable]..
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