Burkholderia cenocepacia J2315

Summary

Alias: Burkholderia cenocepacia str. J2315, Burkholderia cepacia J2315, Burkholderia cepacia str. J2315

Top Publications

  1. pmc Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections
    Aygun Israyilova
    Dipartimento di Biologia e Biotecnologie, Universita degli Studi di Pavia, Pavia, Italy
    PLoS ONE 11:e0167350. 2016
  2. doi Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia J2315
    Christian G Ramos
    Institute for Biotechnology and Bioengineering, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Av Rovisco Pais, Torre Sul, Piso 6, 1049 001, Lisboa, Portugal
    Genomics 101:139-48. 2013
  3. pmc Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages
    Souhaila Al-Khodor
    Signaling Systems Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
    Cell Microbiol 16:378-95. 2014
  4. doi Involvement of toxin-antitoxin modules in Burkholderia cenocepacia biofilm persistence
    Heleen Van Acker
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium
    Pathog Dis 71:326-35. 2014
  5. pmc Regulation of Hfq mRNA and protein levels in Escherichia coli and Pseudomonas aeruginosa by the Burkholderia cenocepacia MtvR sRNA
    Christian G Ramos
    Department of Bioengineering and Institute for Biotechnology and Bioengineering, Instituto Superior Tecnico, Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 9:e98813. 2014
  6. doi The BCESM genomic region contains a regulator involved in quorum sensing and persistence in Burkholderia cenocepacia J2315
    Heleen Van Acker
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium
    Future Microbiol 9:845-60. 2014
  7. pmc Single amino acid substitution in homogentisate 1,2-dioxygenase is responsible for pigmentation in a subset of Burkholderia cepacia complex isolates
    Laura A Gonyar
    Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA
    Environ Microbiol Rep 7:180-7. 2015
  8. pmc Retraction for Ramos et al., The second RNA chaperone, Hfq2, is also required for survival under stress and full virulence of Burkholderia cenocepacia J2315
    Christian G Ramos
    IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
    J Bacteriol 196:3980. 2014
  9. doi Burkholderia cenocepacia J2315 acyl carrier protein: a potential target for antimicrobials' development?
    Silvia A Sousa
    IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Avenida Rovisco Pais, Torre Sul, Piso 6, 1049 001 Lisboa, Portugal
    Microb Pathog 45:331-6. 2008
  10. pmc Genome-wide transcription start site profiling in biofilm-grown Burkholderia cenocepacia J2315
    Andrea M Sass
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium
    BMC Genomics 16:775. 2015

Patents

  1. RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES

Scientific Experts

  • T Coenye
  • Dong Zhi Wei
  • Vitor Martins dos Santos
  • Yoshiyuki Ohtsubo
  • P Drevinek
  • Keri L Colabroy
  • Matthew Tg Holden
  • Kimberly Musa Specht
  • Christian G Ramos
  • Jorge H Leitão
  • Silvia A Sousa
  • Heleen Van Acker
  • Hualei Wang
  • André M Grilo
  • Joana R Feliciano
  • Andrea Sass
  • Paulo J P da Costa
  • Souhaila Al-Khodor
  • Silvia Buroni
  • Giovanna Riccardi
  • Claudia Udine
  • Silvia Bazzini
  • Eshwar Mahenthiralingam
  • Miguel A Valvano
  • John R W Govan
  • Dominic J Campopiano
  • Wen Li Du
  • Yee Chin Wong
  • Ali Vural
  • Aygun Israyilova
  • Laura A Gonyar
  • Andrea M Sass
  • Iain D C Fraser
  • Dieter Deforce
  • Filip Van Nieuwerburgh
  • Huihui Sun
  • Hans J Nelis
  • Kefeng Ni
  • Leonilde M Moreira
  • Hongkai Bi
  • Maria Rosalia Pasca
  • Crystal L Schmerk
  • Kechi Fang
  • Mustafa Fazli
  • Atif H Asghar
  • Meenakshi G Satpute
  • Adrienne Law
  • J Maxwell Dow
  • Tim Tolker-Nielsen
  • Robert P Ryan
  • Dalila Mil-Homens
  • Elke Peeters
  • Yvonne McCarthy
  • David J Clarke
  • Sin Lui Yeung
  • Yinyue Deng
  • Slade A Loutet
  • Leo Eberl
  • Panagoula Charalabous
  • Paul W Whitby
  • Ross J Langley
  • Volker Briken
  • John H Kehrl
  • Laurent Roberto Chiarelli
  • Kok Wei Lee
  • Viola Camilla Scoffone
  • Chong Shan Shi
  • Fanny M Passot
  • Gordon Y C Cheung
  • Travis J McQuiston
  • Anthony J Yeh
  • Sheila Nathan
  • Franck Pasta
  • Alain Kamgoue
  • Michael Otto
  • Heath Murray
  • Federico Forneris
  • Il Young Hwang
  • David Lane
  • Moataz Abd El Ghany
  • Namiq Q Shixaliyev
  • Lalitha Srinivasan
  • Peter R Williamson
  • Nelly Dubarry
  • Arnab Pain
  • Raeece Naeem
  • Yung Chie Tan
  • Joe B Blumer
  • Konrad U Förstner
  • Xuedong Wang

Detail Information

Publications49

  1. pmc Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections
    Aygun Israyilova
    Dipartimento di Biologia e Biotecnologie, Universita degli Studi di Pavia, Pavia, Italy
    PLoS ONE 11:e0167350. 2016
    ..To this aim, we recombinantly produced and characterized glutamate racemase from Burkholderia cenocepacia J2315. From the screening of an in-house library of compounds, two Zn (II) and Mn (III) 1,3,5-..
  2. doi Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia J2315
    Christian G Ramos
    Institute for Biotechnology and Bioengineering, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Av Rovisco Pais, Torre Sul, Piso 6, 1049 001, Lisboa, Portugal
    Genomics 101:139-48. 2013
    ..The human opportunistic pathogen Burkholderia cenocepacia J2315 encodes two distinct RNA chaperones, Hfq and Hfq2...
  3. pmc Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages
    Souhaila Al-Khodor
    Signaling Systems Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA
    Cell Microbiol 16:378-95. 2014
    ..cenocepacia susceptibility, identifying autophagy manipulation as a potential therapeutic approach to reduce bacterial burden in B. cenocepacia infections. ..
  4. doi Involvement of toxin-antitoxin modules in Burkholderia cenocepacia biofilm persistence
    Heleen Van Acker
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium
    Pathog Dis 71:326-35. 2014
    ..In this study, we investigated whether TA modules contribute to persistence toward antibiotics in Burkholderia cenocepacia J2315. Sixteen pairs of genes were identified based on their apparent similarity to TA modules...
  5. pmc Regulation of Hfq mRNA and protein levels in Escherichia coli and Pseudomonas aeruginosa by the Burkholderia cenocepacia MtvR sRNA
    Christian G Ramos
    Department of Bioengineering and Institute for Biotechnology and Bioengineering, Instituto Superior Tecnico, Universidade de Lisboa, Lisboa, Portugal
    PLoS ONE 9:e98813. 2014
    ..MtvR is a 136-nucleotide long sRNA previously identified in the human pathogen Burkholderia cenocepacia J2315 and with homologues restricted to bacteria of the Burkholderia cepacia complex...
  6. doi The BCESM genomic region contains a regulator involved in quorum sensing and persistence in Burkholderia cenocepacia J2315
    Heleen Van Acker
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium
    Future Microbiol 9:845-60. 2014
    In this study, we investigated the function of BCAM0257-8-9 located in the BCESM region of the Burkholderia cenocepacia J2315 genome.
  7. pmc Single amino acid substitution in homogentisate 1,2-dioxygenase is responsible for pigmentation in a subset of Burkholderia cepacia complex isolates
    Laura A Gonyar
    Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA
    Environ Microbiol Rep 7:180-7. 2015
    ..b>Burkholderia cenocepacia J2315 is a CF clinical isolate that displays a pigmented phenotype when grown under normal laboratory ..
  8. pmc Retraction for Ramos et al., The second RNA chaperone, Hfq2, is also required for survival under stress and full virulence of Burkholderia cenocepacia J2315
    Christian G Ramos
    IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
    J Bacteriol 196:3980. 2014
    ..doi.org/10.1016 /j.micpath.2010.02.006. Therefore, we retract the paper.Wedeeply regret this situation and apologize for any inconvenience to the editors and readers of Journal of Bacteriology, Microbial Pathogenesis, and Microbiology...
  9. doi Burkholderia cenocepacia J2315 acyl carrier protein: a potential target for antimicrobials' development?
    Silvia A Sousa
    IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Avenida Rovisco Pais, Torre Sul, Piso 6, 1049 001 Lisboa, Portugal
    Microb Pathog 45:331-6. 2008
    This work describes the isolation and characterization of an acyl carrier protein (ACP) mutant from Burkholderia cenocepacia J2315, a strain of the Burkholderia cepacia complex (Bcc)...
  10. pmc Genome-wide transcription start site profiling in biofilm-grown Burkholderia cenocepacia J2315
    Andrea M Sass
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium
    BMC Genomics 16:775. 2015
    ..This study aims to annotate transcription start sites and identify novel transcripts on a whole genome scale...
  11. pmc Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection
    Ali Vural
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 196:846-56. 2016
    ..High levels of AGS3 in macrophages enhanced their resistance to infection by Burkholderia cenocepacia J2315, Mycobacterium tuberculosis, and methicillin-resistant Staphylococcus aureus, whereas AGS3-deficient ..
  12. pmc Orderly Replication and Segregation of the Four Replicons of Burkholderia cenocepacia J2315
    Wen Li Du
    Laboratoire de Microbiologie et Genetique Moleculaires, Centre National de Recherche Scientifique Université Paul Sabatier, Toulouse, France
    PLoS Genet 12:e1006172. 2016
    ..In particular, the absence of the c1 ParA protein altered replication of all three chromosomes, suggesting that the partition system of the main chromosome is a major participant in the choreography of the cell cycle. ..
  13. pmc Candidate Essential Genes in Burkholderia cenocepacia J2315 Identified by Genome-Wide TraDIS
    Yee Chin Wong
    Faculty of Science and Technology, School of Biosciences and Biotechnology, Universiti Kebangsaan Malaysia Bangi, Malaysia
    Front Microbiol 7:1288. 2016
    ..The library of B. cenocepacia mutants can subsequently be subjected to various biologically related conditions to facilitate the discovery of genes involved in niche adaptation as well as pathogenicity and virulence. ..
  14. pmc Protein engineering of a nitrilase from Burkholderia cenocepacia J2315 for efficient and enantioselective production of (R)-o-chloromandelic acid
    Hualei Wang
    State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai, People s Republic of China
    Appl Environ Microbiol 81:8469-77. 2015
    ..Insight into the source of enantioselectivity and activity was gained by homology modeling and molecular docking experiments. ..
  15. ncbi Identification of an RTX determinant of Burkholderia cenocepacia J2315 by subtractive hybridization
    Paul W Whitby
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Med Microbiol 55:11-21. 2006
    This study utilized suppressive subtractive hybridization between the clinical isolate Burkholderia cenocepacia J2315 and the closely related environmental isolate Burkholderia cepacia ATCC 25416(T) to isolate DNA fragments specific to B...
  16. ncbi Temperate bacteriophages DK4 and BcepMu from Burkholderia cenocepacia J2315 are identical
    Ross J Langley
    Cystic Fibrosis Laboratory, Medical Microbiology, University of Edinburgh, Medical School, Teviot Place, EH8 9AG, United Kingdom
    FEMS Immunol Med Microbiol 45:349-50. 2005
  17. doi Efficient production of (R)-(-)-mandelic acid in biphasic system by immobilized recombinant E. coli
    Kefeng Ni
    State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, China
    J Biotechnol 167:433-40. 2013
    The recombinant Escherichia coli M15/BCJ2315 which harbored a mandelonitrilase from Burkholderia cenocepacia J2315 was immobilized via catecholic chitosan and functionalized with magnetism by iron oxide nanoparticles...
  18. pmc MtvR is a global small noncoding regulatory RNA in Burkholderia cenocepacia
    Christian G Ramos
    Department of Bioengineering, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Lisbon, Portugal
    J Bacteriol 195:3514-23. 2013
    b>Burkholderia cenocepacia J2315 is a highly epidemic and transmissible clinical isolate of the Burkholderia cepacia complex (Bcc), a group of bacteria causing life-threatening respiratory infections among cystic fibrosis patients...
  19. pmc Phenotypic and genotypic characterisation of Burkholderia cenocepacia J2315 mutants affected in homoserine lactone and diffusible signal factor-based quorum sensing systems suggests interplay between both types of systems
    Claudia Udine
    Dipartimento di Biologia e Biotecnologie, Universita degli Studi di Pavia, Pavia, Italy
    PLoS ONE 8:e55112. 2013
    ..As the expression of the gene encoding the C6-HSL synthase CciI (and to a lesser extent the C8-HSL synthase CepI) is partially controlled by BDSF, it seems likely that the BDSF QS systems controls AHL production through this system...
  20. pmc Discovery and characterization of a highly efficient enantioselective mandelonitrile hydrolase from Burkholderia cenocepacia J2315 by phylogeny-based enzymatic substrate specificity prediction
    Hualei Wang
    State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People s Republic of China
    BMC Biotechnol 13:14. 2013
    ..An ideal nitrilase that can efficiently hydrolyze mandelonitrile to optically pure (R)-(-)-mandelic acid without the unwanted byproduct is needed...
  21. pmc Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-D-mannose 4,6-dehydratase
    Silvia A Sousa
    Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisboa, Portugal
    PLoS ONE 8:e56902. 2013
    This work reports the biochemical and functional analysis of the Burkholderia cenocepacia J2315 bceN gene, encoding a protein with GDP-D-mannose 4,6-dehydratase enzyme activity (E.C.4.2.1.47)...
  22. pmc The novel cis-encoded small RNA h2cR is a negative regulator of hfq2 in Burkholderia cenocepacia
    Christian G Ramos
    Institute for Biotechnology and Bioengineering, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Lisboa, Portugal
    PLoS ONE 7:e47896. 2012
    ..and functional analysis of the novel cis-encoded sRNA h2cR, from the human opportunistic pathogen Burkholderia cenocepacia J2315. The sRNA was found to negatively regulate the hfq2 mRNA, through binding to part of the 5'-UTR region ..
  23. pmc The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities
    Hongkai Bi
    Departments of Microbiology Biochemistry, B103 Chemical and Life Sciences Laboratory, University of Illinois, 601 S Goodwin Ave, Urbana, IL 61801, USA
    Mol Microbiol 83:840-55. 2012
    ..Both activities required the same set of active-site residues. Although dehydratase and thioesterase activities are known activities of the crotonase superfamily, Bcam0581 is the first protein shown to have both activities...
  24. pmc Hopanoid production is required for low-pH tolerance, antimicrobial resistance, and motility in Burkholderia cenocepacia
    Crystal L Schmerk
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, N6A 5C1, Canada
    J Bacteriol 193:6712-23. 2011
    ..Loss of hopanoid production also resulted in severe defects in both swimming and swarming motility. This suggests that hopanoid production plays an important role in the physiology of B. cenocepacia...
  25. doi The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia
    Mustafa Fazli
    Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Mol Microbiol 82:327-41. 2011
    ..Taken together, these findings suggest that the Bcam1349 protein is a transcriptional regulator that binds c-di-GMP and regulates biofilm formation and virulence in B. cenocepacia in response to the level of c-di-GMP...
  26. pmc Deciphering the role of RND efflux transporters in Burkholderia cenocepacia
    Silvia Bazzini
    Dipartimento di Genetica e Microbiologia, Universita degli Studi di Pavia, Pavia, Italy
    PLoS ONE 6:e18902. 2011
    b>Burkholderia cenocepacia J2315 is representative of a highly problematic group of cystic fibrosis (CF) pathogens. Eradication of B...
  27. doi Expression and characterization of penicillin-binding proteins in Burkholderia cenocepacia
    Kimberly Musa Specht
    Department of Chemistry and Biochemistry, Denison University, Granville, USA
    Curr Microbiol 60:274-9. 2010
    ..coli. The fusion proteins were isolated and shown to bind beta-lactams, indicating these putative PBPs have penicillin-binding activity...
  28. ncbi Identification and physical organization of the gene cluster involved in the biosynthesis of Burkholderia cepacia complex exopolysaccharide
    Leonilde M Moreira
    Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
    Biochem Biophys Res Commun 312:323-33. 2003
    ..and comparison of the nucleotide sequence of the interrupted genes with the available genome of Burkholderia cenocepacia J2315. This 16.2 kb cluster includes 12 genes and is located on chromosome 2...
  29. pmc Tryptophan catabolism: identification and characterization of a new degradative pathway
    Keri L Colabroy
    Department of Chemistry, Muhlenberg College, Allentown, PA 18104, USA
    J Bacteriol 187:7866-9. 2005
    A new tryptophan catabolic pathway is characterized from Burkholderia cepacia J2315. In this pathway, tryptophan is converted to 2-amino-3-carboxymuconate semialdehyde, which is enzymatically degraded to pyruvate and acetate via the ..
  30. ncbi Identification of a response regulator gene for catabolite control from a PCB-degrading beta-proteobacteria, Acidovorax sp. KKS102
    Yoshiyuki Ohtsubo
    Department of Environmental Life Sciences, Graduate School of Life Sciences, 2 1 1 Katahira, Sendai 980 8577, Japan
    Mol Microbiol 60:1563-75. 2006
    ..The genes highly similar to bphQ were found from several beta-proteobacteria, such as Burkholderia cenocepacia J2315, B. multivorans ATCC17616, B. xenovorans LB400 and Ralstonia solanacearum RS1085.
  31. ncbi Characterization of a bifunctional catalase-peroxidase of Burkholderia cenocepacia
    Panagoula Charalabous
    Microbiology, The University of Liverpool, Liverpool, UK
    FEMS Immunol Med Microbiol 50:37-44. 2007
    ..cenocepacia (katA). MS analysis indicated that the initial katG translation product may be post-translationally modified in B. cenocepacia to give rise to the mature 97-kDa catalase-peroxidase...
  32. ncbi Identification of putative noncoding RNA genes in the Burkholderia cenocepacia J2315 genome
    Tom Coenye
    Laboratorium voor Microbiologie, Universiteit Gent, Gent, Belgium
    FEMS Microbiol Lett 276:83-92. 2007
    ..In the present study, the presence of ncRNA genes in the genome of Burkholderia cenocepacia J2315 was evaluated by combining comparative genomics (alignment-based) and predicted secondary structure ..
  33. doi Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities
    Silvia A Sousa
    IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal
    Appl Microbiol Biotechnol 80:1015-22. 2008
    The bceA(J) gene from the cystic fibrosis isolate Burkholderia cenocepacia J2315 encodes a 56-kDa bifunctional protein, with phosphomannose isomerase (PMI) and guanosine diphosphate (GDP)-mannose pyrophosphorylase (GMP) activities, a new ..
  34. pmc Gene expression changes linked to antimicrobial resistance, oxidative stress, iron depletion and retained motility are observed when Burkholderia cenocepacia grows in cystic fibrosis sputum
    Pavel Drevinek
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    BMC Infect Dis 8:121. 2008
    ..Their large genome (> 7000 genes) and multiple pathways encoding the same putative functions make virulence factor identification difficult in these bacteria...
  35. pmc The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients
    Matthew T G Holden
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, United Kingdom
    J Bacteriol 191:261-77. 2009
    ..The J2315 genome contains evidence that its unique and highly adapted genetic content has played a significant role in its success as an epidemic CF pathogen...
  36. doi Purple acid phosphatase-like sequences in prokaryotic genomes and the characterization of an atypical purple alkaline phosphatase from Burkholderia cenocepacia J2315
    Sin Lui Yeung
    School of Biological Sciences, University of Hong Kong, Hong Kong, China
    Gene 440:1-8. 2009
    ..A putative PAP gene (BcPAP) from the bacteria Burkholderia cenocepacia J2315 was chosen for further studies...
  37. doi Contributions of two UDP-glucose dehydrogenases to viability and polymyxin B resistance of Burkholderia cenocepacia
    Slade A Loutet
    Department of Microbiology and Immunology, Infectious Diseases Research Group, Siebens Drake Research Institute, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Microbiology 155:2029-39. 2009
    ..cenocepacia but only the most highly expressed ugd gene, ugd(BCAL2946), is required for polymyxin B resistance...
  38. pmc Differential modulation of Burkholderia cenocepacia virulence and energy metabolism by the quorum-sensing signal BDSF and its synthase
    Yinyue Deng
    Institute of Molecular and Cell Biology, Proteos, Singapore
    J Bacteriol 191:7270-8. 2009
    ..These data demonstrate that in addition to the role in cross-kingdom signal interference, BDSF and its synthase are also important for the virulence and physiology of B. cenocepacia...
  39. pmc Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction
    Kechi Fang
    Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
    BMC Syst Biol 5:83. 2011
    ..There is a strong demand to reconstruct a genome-scale metabolic network of B. cenocepacia J2315 to systematically analyze its metabolic capabilities and its virulence traits, and to search for potential clinical therapy targets...
  40. doi Genome-wide analysis of DNA repeats in Burkholderia cenocepacia J2315 identifies a novel adhesin-like gene unique to epidemic-associated strains of the ET-12 lineage
    Dalila Mil-Homens
    IBB Institute for Biotechnology and Bioengineering, Center for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon 1049 001, Portugal
    Microbiology 156:1084-96. 2010
    ..The genome of Burkholderia cenocepacia J2315, a CF isolate belonging to the epidemic lineage Edinburgh-Toronto (ET-12), was analysed for the ..
  41. doi Subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins based on catalytic activity
    David J Clarke
    SIRCAMS, School of Chemistry, University of Edinburgh, Edinburgh, UK
    Biochemistry 49:1319-30. 2010
    ..To our knowledge, this is the first detailed characterization of their catalytic activity. These studies support the subdivision of the BCP family of peroxiredoxins into two classes based on their catalytic activity...
  42. pmc Transcriptional response of Burkholderia cenocepacia J2315 sessile cells to treatments with high doses of hydrogen peroxide and sodium hypochlorite
    Elke Peeters
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium
    BMC Genomics 11:90. 2010
    ..cenocepacia J2315 cells following exposure to high levels of H2O2 or NaOCl...
  43. doi A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia
    Yvonne McCarthy
    BIOMERIT Research Centre, Department of Microbiology, Biosciences Institute, University College Cork, Cork, Ireland
    Mol Microbiol 77:1220-36. 2010
    ..The findings identify BCAM0227 as a novel BDSF sensor and a potential target for interference in virulence-related signalling in B. cenocepacia...
  44. doi The pobA gene of Burkholderia cenocepacia encodes a group I Sfp-type phosphopantetheinyltransferase required for biosynthesis of the siderophores ornibactin and pyochelin
    Atif H Asghar
    Department of Infection and Immunity, The Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
    Microbiology 157:349-61. 2011
    ..Finally, we confirmed that Sfp-type bacterial PPTases can be subdivided into two distinct groups, and we present the amino acid signature sequences which characterize each of these groups...
  45. pmc The second RNA chaperone, Hfq2, is also required for survival under stress and full virulence of Burkholderia cenocepacia J2315
    Christian G Ramos
    Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Torre Sul, Piso 6 Av Rovisco Pais, 1049 001 Lisbon, Portugal
    J Bacteriol 193:1515-26. 2011
    b>Burkholderia cenocepacia J2315 is a highly virulent and epidemic clinical isolate of the B. cepacia complex (Bcc), a group of bacteria that have emerged as important pathogens to cystic fibrosis patients...
  46. pmc Molecular mechanisms of chlorhexidine tolerance in Burkholderia cenocepacia biofilms
    Tom Coenye
    Laboratory of Pharmaceutical Microbiology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Antimicrob Agents Chemother 55:1912-9. 2011
    ..In the present study, we analyzed the tolerance of planktonic and sessile Burkholderia cenocepacia J2315 cultures and examined the transcriptional response of sessile cells to treatment with chlorhexidine...
  47. pmc Defining a structural and kinetic rationale for paralogous copies of phenylacetate-CoA ligases from the cystic fibrosis pathogen Burkholderia cenocepacia J2315
    Adrienne Law
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    J Biol Chem 286:15577-85. 2011
    ..Collectively, these results offer detailed insight into the reaction mechanism of a novel subgroup of the AFE superfamily and provide a clear biochemical rationale for the presence of paralogous copies of PaaK of B. cenocepacia...
  48. ncbi A putative type III secretion gene cluster is widely distributed in the Burkholderia cepacia complex but absent from genomovar I
    Y N Parsons
    Department of Medical Microbiology and Genitourinary Medicine, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    FEMS Microbiol Lett 203:103-8. 2001
    ..solanacearum and Burkholderia pseudomallei, putative type III secretion (TTS) genes were identified in Burkholderia cepacia J2315 (genomovar III)...
  49. doi Isolation of Burkholderia cenocepacia J 2315 from non-cystic fibrosis pediatric patients in India
    Meenakshi G Satpute
    Department of Clinical Microbiology, King Edward Memorial Hospital, Interdisciplinary School of Biomedical Sciences of University of Pune Affiliate, Pune, India
    Am J Infect Control 39:e21-3. 2011
    We report for the first time 2 cases of multidrug-resistant Burkholderia cenocepacia J2315 isolated from blood samples of patients without cystic fibrosis from a pediatric unit in a hospital in India...

Patents1

  1. RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES
    Patent Number: KR1020130117753-A; Date:2013-10-28