Streptococcus pyogenes M1 GAS

Summary

Alias: Streptococcus pyogenes (serotype 1 / M1 GAS), Streptococcus pyogenes ATCC 700294, Streptococcus pyogenes SF370, Streptococcus pyogenes strain SF370

Top Publications

  1. ncbi A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin
    V Kapur
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030
    Microb Pathog 15:327-46. 1993
  2. ncbi Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules
    A Roussel
    Department of Biochemistry, Massey University, Palmerston North, New Zealand
    Nat Struct Biol 4:635-43. 1997
  3. ncbi Identification of csrR/csrS, a genetic locus that regulates hyaluronic acid capsule synthesis in group A Streptococcus
    J C Levin
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Mol Microbiol 30:209-19. 1998
  4. pmc Identification and characterization of novel superantigens from Streptococcus pyogenes
    T Proft
    Department of Molecular Medicine, School of Medicine, University of Auckland, 92019 Auckland, New Zealand
    J Exp Med 189:89-102. 1999
  5. pmc The streptococcal superantigen SMEZ exhibits wide allelic variation, mosaic structure, and significant antigenic variation
    T Proft
    Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
    J Exp Med 191:1765-76. 2000
  6. pmc Identification and characterization of a Streptococcus pyogenes operon involved in binding of hemoproteins and acquisition of iron
    Christopher S Bates
    Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303, USA
    Infect Immun 71:1042-55. 2003
  7. ncbi alpha2-Macroglobulin-proteinase complexes protect Streptococcus pyogenes from killing by the antimicrobial peptide LL-37
    Patrik Nyberg
    Section for Clinical and Experimental Infectious Medicine, Department of Cell and Molecular Biology, Lund University, BMC, B14, Tornavagen 10, S 22184 Lund, Sweden
    J Biol Chem 279:52820-3. 2004
  8. ncbi Trigger for group A streptococcal M1T1 invasive disease
    Jason N Cole
    School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, 2522, Australia
    FASEB J 20:1745-7. 2006
  9. ncbi Streptococcal mitogenic exotoxin, SmeZ, is the most susceptible M1T1 streptococcal superantigen to degradation by the streptococcal cysteine protease, SpeB
    Mohammed M Nooh
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 281:35281-8. 2006
  10. pmc Induction of group A Streptococcus virulence by a human antimicrobial peptide
    Ioannis Gryllos
    Division of Infectious Diseases, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:16755-60. 2008

Research Grants

  1. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2004
  2. Molecular Evolution of Resistance in Strep. pyogenes
    DEBRA BESSEN; Fiscal Year: 2005
  3. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2007
  4. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2009

Patents

  1. METHODS FOR PRODUCING GENETIC MODIFICATIONS IN A PLANT GENOME WITHOUT INCORPORATING A SELECTABLE TRANSGENE MARKER, AND COMPOSITIONS THEREOF
  2. PLANT GENOME MODIFICATION USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS AND METHODS OF USE
  3. A SOYBEAN U6 POLYMERASE III PROMOTER AND METHODS OF USE
  4. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
  5. Plants with increased yield
  6. Plants with increased yield
  7. Lipid metabolism proteins, combinations of lipid metabolism proteins and uses thereof
  8. Process for the production of lutein
  9. Plants with increased yield by increasing or generating one or more activities in a plant or a part thereof
  10. Process for the production of fine chemicals

Scientific Experts

Detail Information

Publications126 found, 100 shown here

  1. ncbi A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin
    V Kapur
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030
    Microb Pathog 15:327-46. 1993
    ..pyogenes, provide additional evidence that this enzyme is involved in host-parasite interactions, and suggest that the protease plays a role in bacterial dissemination, colonization, and invasion, and inhibition of wound healing...
  2. ncbi Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules
    A Roussel
    Department of Biochemistry, Massey University, Palmerston North, New Zealand
    Nat Struct Biol 4:635-43. 1997
    ..Consideration of the SPE-C dimer suggests a novel mechanism for promotion of MHC aggregation and T-cell activation...
  3. ncbi Identification of csrR/csrS, a genetic locus that regulates hyaluronic acid capsule synthesis in group A Streptococcus
    J C Levin
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Mol Microbiol 30:209-19. 1998
    ..These results establish CsrR as a negative regulator of hyaluronic acid capsule synthesis and suggest that it is part of a two-component regulatory system that influences capsule expression and virulence...
  4. pmc Identification and characterization of novel superantigens from Streptococcus pyogenes
    T Proft
    Department of Molecular Medicine, School of Medicine, University of Auckland, 92019 Auckland, New Zealand
    J Exp Med 189:89-102. 1999
    ..The most common targets for the novel SAgs were human Vbeta2.1- and Vbeta4-expressing T cells. This might reflect a specific role for this subset of Vbetas in the immune defense of gram-positive bacteria...
  5. pmc The streptococcal superantigen SMEZ exhibits wide allelic variation, mosaic structure, and significant antigenic variation
    T Proft
    Department of Molecular Medicine, School of Medicine, University of Auckland, Auckland, New Zealand
    J Exp Med 191:1765-76. 2000
    ..SMEZ-specific Vbeta8 activity was found in culture supernatants of 66% of the GAS isolates, indicating a potential base for the development of a SMEZ targeting vaccine...
  6. pmc Identification and characterization of a Streptococcus pyogenes operon involved in binding of hemoproteins and acquisition of iron
    Christopher S Bates
    Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, Georgia 30303, USA
    Infect Immun 71:1042-55. 2003
    ..SiaA and Shr are the first hemoprotein receptors identified in S. pyogenes; their possible role in iron capture is discussed...
  7. ncbi alpha2-Macroglobulin-proteinase complexes protect Streptococcus pyogenes from killing by the antimicrobial peptide LL-37
    Patrik Nyberg
    Section for Clinical and Experimental Infectious Medicine, Department of Cell and Molecular Biology, Lund University, BMC, B14, Tornavagen 10, S 22184 Lund, Sweden
    J Biol Chem 279:52820-3. 2004
    ..pyogenes, is trapped by alpha(2)M bound to protein GRAB. As a consequence, SpeB is retained at the bacterial surface and protects S. pyogenes against killing by the antibacterial peptide LL-37...
  8. ncbi Trigger for group A streptococcal M1T1 invasive disease
    Jason N Cole
    School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, 2522, Australia
    FASEB J 20:1745-7. 2006
    ..pyogenes M1T1 with the human plasminogen activation system. Loss of SpeB activity in a subpopulation of S. pyogenes M1T1 at the site of infection results in accumulation of surface plasmin activity thus triggering systemic spread...
  9. ncbi Streptococcal mitogenic exotoxin, SmeZ, is the most susceptible M1T1 streptococcal superantigen to degradation by the streptococcal cysteine protease, SpeB
    Mohammed M Nooh
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 281:35281-8. 2006
    ..The study provides evidence for the effect of subtle structural differences between highly similar SAgs on their biological activity...
  10. pmc Induction of group A Streptococcus virulence by a human antimicrobial peptide
    Ioannis Gryllos
    Division of Infectious Diseases, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:16755-60. 2008
    ..The ability of GAS to sense and respond to LL-37 may explain, at least in part, the unique susceptibility of the human species to streptococcal infection...
  11. ncbi Immunological and biochemical characterization of streptococcal pyrogenic exotoxins I and J (SPE-I and SPE-J) from Streptococcus pyogenes
    T Proft
    Division of Molecular Medicine and School of Biological Sciences, University of Auckland, Auckland, New Zealand
    J Immunol 166:6711-9. 2001
    ..Despite a primary sequence diversity of 51%, SPE-J is functionally indistinguishable from SPE-C and might play a role in streptococcal disease, which has previously been addressed to SPE-C...
  12. pmc Ribosomal mutations in Streptococcus pneumoniae clinical isolates
    Marja Pihlajamäki
    Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland
    Antimicrob Agents Chemother 46:654-8. 2002
    ....
  13. pmc Emergence of group A streptococcus strains with different mechanisms of macrolide resistance
    Edouard Bingen
    Service de Microbiologie, Hopital Robert Debre, Paris, France
    Antimicrob Agents Chemother 46:1199-203. 2002
    ..In the two remaining posttreatment strains, the mechanisms of macrolide resistance could not be elucidated...
  14. ncbi Resistance to macrolides in clinical isolates of Streptococcus pyogenes due to ribosomal mutations
    Brigitte Malbruny
    Service de Microbiologie, Hôpital Côte de Nacre, UFR de Medecine, av Côte de Nacre, 14033 Caen, France
    J Antimicrob Chemother 49:935-9. 2002
    ..The aim of the study was to determine the mechanisms of macrolide resistance in both strains...
  15. ncbi Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes
    Robert J Edwards
    Section of Experimental Medicine and Toxicology, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Infect Dis 192:783-90. 2005
    ..Cleavage of IL-8 by S. pyogenes represents an unprecedented mechanism of immune evasion, effectively preventing IL-8 C-terminus-mediated endothelial translocation and subsequent recruitment of neutrophils...
  16. pmc Characterization of the Streptococcus mutans GS-5 fruA gene encoding exo-beta-D-fructosidase
    R A Burne
    Department of Dental Research, University of Rochester Medical Center, New York 14642
    Infect Immun 60:4621-32. 1992
    ..The data begin to define functional domains of the FruA protein and potential regulatory sites for induction, repression, growth rate control, and posttranslational localization of this multifunctional enzyme...
  17. ncbi Cloning, sequence analysis and expression of the group A streptococcal guaB gene encoding inosine monophosphate dehydrogenase
    C D Ashbaugh
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Gene 165:57-60. 1995
    ..Restriction mapping and Southern hybridization analysis of GAS chromosomal DNA localized guaB to a site approximately 5 kb from the hasA and hasB genes which encode enzymes necessary for hyaluronic acid capsule synthesis...
  18. ncbi Molecular characterization of hasC from an operon required for hyaluronic acid synthesis in group A streptococci. Demonstration of UDP-glucose pyrophosphorylase activity
    D L Crater
    Wake Forest University Medical Center, Winston Salem, North Carolina 27157, USA
    J Biol Chem 270:28676-80. 1995
    ..Finally, since sequence analysis identified a potential rho-independent transcription terminator at the 3-prime terminus of the gene, hasC is the third and probably the final gene in the has operon...
  19. ncbi 6-Phospho-beta-galactosidases of gram-positive and 6-phospho-beta-glucosidase B of gram-negative bacteria: comparison of structure and function by kinetic and immunological methods and mutagenesis of the lacG gene of Staphylococcus aureus
    E Witt
    Abteilung für Biologie, Ruhr Universitat Bochum, Germany
    Protein Eng 6:913-20. 1993
    ..In the totally inactive mutant protein only the glycine at position 332 was changed to an arginine. This amino acid is part of the sequence insertion near the antigenic domain reacting with both antisera.(ABSTRACT TRUNCATED AT 250 WORDS)..
  20. pmc Isolation and characterization of the lantibiotic salivaricin A and its structural gene salA from Streptococcus salivarius 20P3
    K F Ross
    Department of Microbiology, University of Otago, Dunedin, New Zealand
    Appl Environ Microbiol 59:2014-21. 1993
    ..The sequence around the cleavage site of presalivaricin A differed from that of other type A lantibiotics but was similar to that of several bacteriocin-like inhibitory substances produced by lactic acid bacteria...
  21. ncbi Cloning, characterization and overexpression of a Streptococcus pyogenes gene encoding a new type of mitogenic factor
    M Iwasaki
    Shionogi Institute for Medical Science, Osaka, Japan
    FEBS Lett 331:187-92. 1993
    ..pyogenes. These data indicate that a unique gene encoding MF was cloned from S. pyogenes...
  22. ncbi Protein SIC, a novel extracellular protein of Streptococcus pyogenes interfering with complement function
    P Akesson
    Department of Cell and Molecular Biology, Lund University, Sweden
    J Biol Chem 271:1081-8. 1996
    ..Thus, during recent years, the M1 serotype has been connected with a world-wide increase of severe and toxic S. pyogenes infections...
  23. ncbi Characterization of the locus encoding the Streptococcus pneumoniae type 19F capsular polysaccharide biosynthetic pathway
    J K Morona
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, Australia
    Mol Microbiol 23:751-63. 1997
    ..pneumoniae serotypes/groups tested. The region from cps19fG to cps19fK was found only in members of serogroup 19, and, within this, cps19fl was unique to type 19F...
  24. ncbi The group A streptococcal dipeptide permease (Dpp) is involved in the uptake of essential amino acids and affects the expression of cysteine protease
    A Podbielski
    Department of Medical Microbiology and Hygiene, University Hospital Ulm, Germany
    Mol Microbiol 28:1323-34. 1998
    ..Taken together, these data indicate a correlation between levels of intracellular essential amino acids and the regulation of virulence factor expression...
  25. pmc A role for trigger factor and an rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes
    W R Lyon
    Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, St Louis, MO 63110 1093, USA
    EMBO J 17:6263-75. 1998
    ..These results provide insight into the function of Trigger Factor, the regulation of proteinase activity and the mechanism of secretion in Gram-positive bacteria...
  26. pmc Analysis of the 5' portion of the type 19A capsule locus identifies two classes of cpsC, cpsD, and cpsE genes in Streptococcus pneumoniae
    J K Morona
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, South Australia 5006
    J Bacteriol 181:3599-605. 1999
    ..Whereas members within one class are greater than 95% identical to each other, the DNA sequence identity between the two classes is only approximately 70%...
  27. pmc Comparative genetics of capsular polysaccharide biosynthesis in Streptococcus pneumoniae types belonging to serogroup 19
    J K Morona
    Molecular Microbiology Unit, Women s and Children s Hospital, North Adelaide, South Australia 5006
    J Bacteriol 181:5355-64. 1999
    ....
  28. pmc Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: an integrin-binding cysteine protease
    T F Kagawa
    School of Biological Sciences, Department of Chemistry, University of Auckland, Private Bag 92 019, Auckland, New Zealand
    Proc Natl Acad Sci U S A 97:2235-40. 2000
    ..The structure also reveals the surface location of an integrin-binding Arg-Gly-Asp (RGD) motif that is a feature unique to SpeB among cysteine proteases and is linked to the pathogenesis of the most invasive strains of S. pyogenes...
  29. ncbi Replication origin of Streptococcus pyogenes, organization and cloning in heterologous systems
    A N Suvorov
    Institute of Experimental Medicine, Academy of Medical Sciences, St Petersburg, Russia
    FEMS Microbiol Lett 189:293-7. 2000
    ..The chromosomal organization of the oriC region of GAS relative to other bacterial species appears to be similar to oriC of Bacillus subtilis and other Gram-positive microorganisms...
  30. pmc Genetic polymorphisms of group B streptococcus scpB alter functional activity of a cell-associated peptidase that inactivates C5a
    J F Bohnsack
    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Infect Immun 68:5018-25. 2000
    ..The ubiquitous expression of C5a-ase, irrespective of functional activity, suggests that C5a-ase may have a second, as yet unidentified, function...
  31. ncbi New gene cluster for lantibiotic streptin possibly involved in streptolysin S formation
    K Karaya
    Department of Biochemistry I, Fukui Medical University, Shimoaizuki, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    J Biochem 129:769-75. 2001
    ..The fact that N22 also lost the anti-bacterial activity against indicator streptococci reveals that the factor(s) required for lantibiotic formation plays an important role in SLS formation as well...
  32. ncbi Characterization and immunogenicity of pyrogenic mitogens SePE-H and SePE-I of Streptococcus equi
    S C Artiushin
    Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546, USA
    Microb Pathog 32:71-85. 2002
    ..equi from its putative S. zooepidemicus ancestor...
  33. ncbi Immunisation of dairy cattle with recombinant Streptococcus uberis GapC or a chimeric CAMP antigen confers protection against heterologous bacterial challenge
    Michael C Fontaine
    Veterinary Infectious Disease Organisation, University of Saskatchewan, Saskatoon, Canada
    Vaccine 20:2278-86. 2002
    ..Inflammation was not reduced in S. dysgalactiae (6 x His)GapC vaccinates, suggesting that it does not confer cross-species protection...
  34. ncbi Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes
    Eric J Sundberg
    Center for Advanced Research in Biotechnology, W M Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850, USA
    Structure 10:687-99. 2002
    ..Thus, highly efficient T cell activation may be achieved through structurally diverse strategies of TCR ligation...
  35. pmc Isolation and molecular analysis of the gene cluster for the arginine deiminase system from Streptococcus gordonii DL1
    Yiqian Dong
    Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
    Appl Environ Microbiol 68:5549-53. 2002
    ..Thus, ArcR is a transcriptional activator that is required for induction and optimal expression of the S. gordonii ADS gene cluster...
  36. ncbi Amplifying the cellular reduction potential of Streptococcus zooepidemicus
    Barrie Fong Chong
    Department of Chemical Engineering, The University of Queensland, Brisbane QLD 4072, Australia
    J Biotechnol 100:33-41. 2003
    ..The concomitant excretion of pyruvate at high NADH oxidase levels suggested that the flux through the pyruvate dehydrogenase enzyme complex was limiting the conversion of pyruvate to acetate...
  37. pmc Analysis of a viridans group strain reveals a case of bacteremia due to lancefield group G alpha-hemolytic Streptococcus dysgalactiae subsp equisimilis in a patient with pyomyositis and reactive arthritis
    Patrick C Y Woo
    Department of Microbiology, The University of Hong Kong, Hong Kong
    J Clin Microbiol 41:613-8. 2003
    ..dysgalactiae subsp. equisimilis or a novel type of S. dysgalactiae. The present case showed that group G alpha-hemolytic S. dysgalactiae subsp. equisimilis can be associated with serious invasive infection and poststreptococcal sequelae...
  38. pmc Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes
    Jari Jalava
    Department of Human Microbial Ecology and Inflammation, National Public Health Institute, Kiinamyllynkatu 13, 20520 Turku, Finland
    Ann Clin Microbiol Antimicrob 3:5. 2004
    ..In addition, certain mutations at the ribosomal 23S RNA can cause resistance to macrolides. Mutation at the position 2058 of the 23S rRNA of the Streptococcus pyogenes as a cause of macrolide resistance has not been described before...
  39. pmc Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG
    Katja Wenig
    Department of Structural Research, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 101:17371-6. 2004
    ..Therefore IdeS belongs to a unique family within the CA clan of cysteine proteinases. Based on analogy with inhibitor complexes of papain-like proteinases, we propose a model for substrate binding by IdeS...
  40. ncbi Close correlation of streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes
    Masakado Matsumoto
    Department of Microbiology, Aichi Prefectural Institute of Public Health, Nagoya, Japan
    Microbiol Immunol 49:925-9. 2005
    ..The distribution of each allele was generally emm genotype-specific. Only sdaB7 was found in both emm2 and emm4. The promoter region was highly conserved and DNase B protein was similarly expressed in all alleles...
  41. pmc Mga is sufficient to activate transcription in vitro of sof-sfbX and other Mga-regulated virulence genes in the group A Streptococcus
    Audry C Almengor
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    J Bacteriol 188:2038-47. 2006
    ..These results indicate that additional factors are not required for Mga-specific activation at diverse promoters in vitro, although they do not rule out the potential influence of other components on the Mga virulence regulon in vivo...
  42. pmc Molecular basis of L-rhamnose branch formation in streptococcal coaggregation receptor polysaccharides
    Yasuo Yoshida
    Oral Infection and Immnunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, 30 Convent Drive, Bethesda, MD 20892, USA
    J Bacteriol 188:4125-30. 2006
    ..gordonii 38 and wefH in S. oralis 34. These genes were distinguished by the unique ability of WefC to act on the branched acceptor formed by the action of WefB...
  43. pmc Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase
    William L Sheldon
    Biomolecular and Biomedical Research Centre, School of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
    Biochem J 399:241-7. 2006
    ..Since these enzymes do not have detectable hyaluronidase activity, many family 84 glycoside hydrolases are most likely incorrectly annotated as hyaluronidases...
  44. ncbi Superantigen gene profile, emm type and antibiotic resistance genes among group A streptococcal isolates from Barcelona, Spain
    Alba Rivera
    Servei de Microbiologia1, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret 167, 08025 Barcelona, Spain
    J Med Microbiol 55:1115-23. 2006
    ..The SAg and antibiotic resistance genes appeared to be associated with the emm type and were independent of the disease type...
  45. pmc Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence
    Case McNamara
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Science 319:1405-8. 2008
    ..Idealized M proteins appear to have promise as vaccine immunogens...
  46. doi Regulation of sagA, siaA and scpC by SilCR, a putative signaling peptide of Streptococcus pyogenes
    Kowthar Y Salim
    Department of Microbiology, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    FEMS Microbiol Lett 289:119-25. 2008
    ..pyogenes. In contrast to this report, we found that SilCR did not reduce lesion formation in a subcutaneous murine model of S. pyogenes infection but rather appeared to delay wound healing...
  47. pmc Intramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenes
    Hae Joo Kang
    School of Biological Sciences, University of Auckland, Auckland 1142, New Zealand
    J Biol Chem 284:20729-37. 2009
    ..These effects on stability appear also to be important for pilus assembly...
  48. pmc Contribution of AmyA, an extracellular alpha-glucan degrading enzyme, to group A streptococcal host-pathogen interaction
    Samuel A Shelburne
    Department of Infectious Diseases, MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Microbiol 74:159-74. 2009
    ..These data delineate the molecular mechanisms by which alpha-glucan degradation contributes to GAS host-pathogen interaction, including how GAS uses human salivary alpha-amylase for its own metabolic benefit...
  49. doi Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes
    Chih Cheng Tsou
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, No 1, University Road, Tainan, Taiwan
    Int J Med Microbiol 300:259-64. 2010
    ..PerR binds the promoter region of dpr. Increased iron and hydrogen peroxide concentrations decreased PerR binding to the promoter region of dpr, suggesting that regulation of Dpr by environmental signals is mediated by PerR directly...
  50. pmc The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 group A Streptococcus
    Ericka L Anderson
    From the Departments of Pediatrics and
    J Biol Chem 289:3539-46. 2014
    ..Inactivation of SpeB during the shift to invasive GAS disease allows M1-Fg binding, increasing pathogen phagocyte resistance and proinflammatory activities. ..
  51. pmc Streptococcus pyogenes triggers activation of the human contact system by streptokinase
    Ramona Nitzsche
    Institute of Medical Microbiology, Virology, and Hygiene, Rostock University Medical Centre, Rostock, Germany
    Infect Immun 83:3035-42. 2015
    ..pyogenes triggers the human contact system and stresses the function of soluble and surface located plasmin exploited as a group A streptococcal virulence factor through the action of streptokinase...
  52. pmc Streptolysin S Promotes Programmed Cell Death and Enhances Inflammatory Signaling in Epithelial Keratinocytes during Group A Streptococcus Infection
    Rebecca A Flaherty
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA
    Infect Immun 83:4118-33. 2015
    ....
  53. doi Exploration of fluoroquinolone resistance in Streptococcus pyogenes: comparative structure analysis of wild-type and mutant DNA gyrase
    Raja Mohmed Beema Shafreen
    Bioinformatics Infrastructure Facility, Department of Biotechnology, Alagappa University, Karaikudi 630 003, Tamil Nadu, India
    J Mol Recognit 26:276-85. 2013
    ..Furthermore, a comparative assessment of quinolone derivative with the older generation fluoroquinolones will be of great impact for S. pyogenes-related infections...
  54. pmc Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation
    Tomoko Sumitomo
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, 565 0871, Japan
    J Biol Chem 288:13317-24. 2013
    ..Group A Streptococcus (GAS) translocates across the host epithelial barrier...
  55. pmc Signal transduction through CsrRS confers an invasive phenotype in group A Streptococcus
    Hien J Tran-Winkler
    Division of Infectious Diseases, Children s Hospital Boston, Boston, Massachusetts, United States of America
    PLoS Pathog 7:e1002361. 2011
    ....
  56. pmc A major surface protein on group A streptococci is a glyceraldehyde-3-phosphate-dehydrogenase with multiple binding activity
    V Pancholi
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, New York 10021
    J Exp Med 176:415-26. 1992
    ..The multiple binding capacity of the SDH in conjunction with its GAPDH activity may play a role in the colonization, internalization, and the subsequent proliferation of group A streptococci...
  57. ncbi HPr polymorphism in oral streptococci is caused by the partial removal of the N-terminal methionine
    C Vadeboncoeur
    Department of Biochemistry Sciences and Dental School, Universite Laval, Quebec, Canada
    Biochimie 73:1427-30. 1991
    ..In this communication, we show by N-terminal amino-acid sequencing and by ion-spray mass spectroscopy that these two forms differ by the presence or the absence of the N-terminal methionine...
  58. pmc The thiol-activated toxin streptolysin O does not require a thiol group for cytolytic activity
    M Pinkney
    Department of Microbiology, Medical School, University of Newcastle upon Tyne, England
    Infect Immun 57:2553-8. 1989
    ..These results show that the widely held assumption that the in vitro cytolytic activity of SLO requires an essential Cys residue is not true...
  59. ncbi Identification of the active-site nucleophile in 6-phospho-beta-galactosidase from Staphylococcus aureus by labelling with synthetic inhibitors
    P Staedtler
    Arbeitsgruppe Physiologie der Mikroorganismen, Abteilung Biologie, Ruhr Universitat Bochum, Germany
    Eur J Biochem 232:658-63. 1995
    ..It was shown to be identical to an authentic, synthetic sample. From this, it is evident that E375 is the active-site nucleophile of 6-phospho-galactosidase, consistent with previous findings for enzymes in this family...
  60. pmc Analysis of a second bacteriophage hyaluronidase gene from Streptococcus pyogenes: evidence for a third hyaluronidase involved in extracellular enzymatic activity
    W L Hynes
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Infect Immun 63:3015-20. 1995
    ..These results suggest the presence of a different hyaluronidase gene encoding a protein that is actively secreted into the extracellular milieu...
  61. ncbi Molecular cloning of the gene encoding RecF, a DNA repair enzyme, from Streptococcus pyogenes
    P L DeAngelis
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555, USA
    Gene 156:89-91. 1995
    ..When cloned on a plasmid, recF could complement a S. pyogenes deletion mutant that was sensitive to ultraviolet irradiation and chemical mutagens. This is the first report of a recF sequence from a Gram+ pathogen...
  62. pmc Cloning, sequencing, and expression of a fibronectin/fibrinogen-binding protein from group A streptococci
    H S Courtney
    Veterans Affairs Medical Center, Memphis, Tennessee 38104
    Infect Immun 62:3937-46. 1994
    ..These data suggest that FBP54 may be a surface protein of streptococci that reacts with both Fn and Fgn and therefore may participate in the adhesion of group A streptococci to host cells...
  63. ncbi The identification of rofA, a positive-acting regulatory component of prtF expression: use of an m gamma delta-based shuttle mutagenesis strategy in Streptococcus pyogenes
    G C Fogg
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110 1093
    Mol Microbiol 11:671-84. 1994
    ..pyogenes, which suggests that rofA may act as an activator of prtF in response to an unidentified environmental signal. We speculate that the allele reported here contains a mutation that renders it constitutively active...
  64. pmc The cell-bound fructosyltransferase of Streptococcus salivarius: the carboxyl terminus specifies attachment in a Streptococcus gordonii model system
    C Rathsam
    Institute of Dental Research, Australia
    J Bacteriol 175:4520-7. 1993
    ..This cell-bound activity was released in the presence of sucrose, suggesting that the mode of attachment and release of the S. salivarius FTF in S. gordonii was similar to that in its native host...
  65. ncbi Nucleotide substitutions and small-scale insertion produce size and antigenic variation in group A streptococcal M1 protein
    M P Harbaugh
    Department of Food Science and Nutrition, University of Minnesota, St Paul 55108
    Mol Microbiol 8:981-91. 1993
    ..1 with the addition of a 21 bp insert. This study provides the first evidence that nucleotide substitutions and small insertions are responsible for size and antigenic variation in the N-terminal non-repeat domain of the M protein of GAS...
  66. ncbi What is the size of the group A streptococcal vir regulon? The Mga regulator affects expression of secreted and surface virulence factors
    A Podbielski
    Institute of Medical Microbiology, Technical University RWTH, Aachen, Germany
    Med Microbiol Immunol 185:171-81. 1996
    ..This indicated that in addition to the core vir regulon, Mga directly or indirectly controls a number of genes dispersed throughout the GAS genome...
  67. pmc Constitutive expression of fibronectin binding in Streptococcus pyogenes as a result of anaerobic activation of rofA
    G C Fogg
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Bacteriol 179:6172-80. 1997
    ..These data suggest a model where anaerobic expression of prtF in constitutive hosts is controlled at the level of transcription of rofA and implicate additional factors in this regulatory pathway...
  68. pmc Streptococcal histone-like protein: primary structure of hlpA and protein binding to lipoteichoic acid and epithelial cells
    M W Stinson
    Department of Microbiology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214, USA
    Infect Immun 66:259-65. 1998
    ..These results support a potential role for HlpA in the pathogenesis of streptococcus-induced tissue inflammation...
  69. pmc Reduced virulence of group A streptococcal Tn916 mutants that do not produce streptolysin S
    S D Betschel
    Department of Microbiology, Mount Sinai Hospital, and University of Toronto, Ontario, Canada
    Infect Immun 66:1671-9. 1998
    ..This study demonstrates that SLS-deficient mutants of GAS, belonging to different M serotypes and containing identical Tn916 mutations, are markedly less virulent than their isogenic parents...
  70. pmc Identification of an insertion sequence located in a region encoding virulence factors of Streptococcus pyogenes
    A Berge
    Section for Molecular Pathogenesis, Department of Cell and Molecular Biology, Lund University, Lund, Sweden
    Infect Immun 66:3449-53. 1998
    ..The same or similar insertion sequences were found in most S. pyogenes strains, but the chromosomal location differed among isolates...
  71. ncbi Crystal structure of the catalytic domain of human plasmin complexed with streptokinase
    X Wang
    Crystallography Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104, USA
    Science 281:1662-5. 1998
    ..The carboxyl-terminal domain of streptokinase, which binds near the activation loop of plasminogen, is likely responsible for the contact activation of plasminogen in the complex...
  72. pmc The HPr(Ser) kinase of Streptococcus salivarius: purification, properties, and cloning of the hprK gene
    D Brochu
    GREB, Departement de Biochimie, Faculté des Sciences et de Génie and Faculté de Médecine Dentaire, GREB, Universite Laval, Ste Foy, Quebec, Canada G1K 7P4
    J Bacteriol 181:709-17. 1999
    ..salivarius is not stimulated by FDP or other glycolytic intermediates. The enzyme is inhibited by inorganic phosphate, and its Kms for HPr and ATP are 31 microM and 1 mM, respectively...
  73. ncbi Protein GRAB of streptococcus pyogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulin
    M Rasmussen
    Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, S 221 00 Lund, Sweden
    J Biol Chem 274:15336-44. 1999
    ..This regulation of proteolytic activity at the bacterial surface should affect the host-microbe relation during S. pyogenes infections...
  74. ncbi Nucleotide sequence of the streptococcin A-FF22 lantibiotic regulon: model for production of the lantibiotic SA-FF22 by strains of Streptococcus pyogenes
    R E McLaughlin
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, USA
    FEMS Microbiol Lett 175:171-7. 1999
    ..Located immediately downstream of the scn region is a putative transposase gene, the presence of which supports earlier data that indicated a mobile nature to this region...
  75. pmc Identification, cloning, and expression of the CAMP factor gene (cfa) of group A streptococci
    K Gase
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Infect Immun 67:4725-31. 1999
    ..The results presented here, along with previous reports, indicate that the CAMP factor gene is fairly widespread among streptococci, being present at least in groups A, B, C, G, M, P, R, and U...
  76. ncbi Crystal structure of streptokinase beta-domain
    X Wang
    Crystallography Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104, USA
    FEBS Lett 459:85-9. 1999
    ..The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta...
  77. ncbi Characterization of group A streptococcal strains Sv and Su: determination of emm gene typing and presence of small vir regulon
    K Hong
    Laboratories for Bioengineering and Research, ICR Pharmaceuticals Co, Ltd, Kobe, Japan
    Res Microbiol 151:29-36. 2000
    ..Taken together, the data suggest that M protein could be expressed on the surface of the Sv bacteria, but not on the Su bacteria...
  78. ncbi Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus pyogenes
    V L Arcus
    School of Biological Sciences, University of Auckland, New Zealand
    J Mol Biol 299:157-68. 2000
    ..This allelic variation, coupled with the varied binding modes of SAgs to MHC-II and TCR, highlights the pressure on SAgs to avoid host immune defences...
  79. ncbi Purification and biochemical characterization of a basic superantigen (SPEX/SMEZ3) from Streptococcus pyogenes
    D Gerlach
    Institute of Medical Microbiology, Friedrich Schiller University Jena, Semmelweisstr, Jena, Germany
    FEMS Microbiol Lett 188:153-63. 2000
    ..The purified SPEX stimulated human T-lymphocytes with Vbeta8 specificity at extremely low concentrations (lower than 100 pg ml(-1))...
  80. ncbi Molecular epidemiology of nga and NAD glycohydrolase/ADP-ribosyltransferase activity among Streptococcus pyogenes causing streptococcal toxic shock syndrome
    D L Stevens
    Infectious Disease Section, Veterans Affairs Medical Center, Boise, ID 83702, USA
    J Infect Dis 182:1117-28. 2000
    ..In summary, the temporal relationship of NADase expression, alone or with other streptococcal virulence factors, may contribute to the pathogenesis of invasive GAS infections...
  81. pmc Functional characterization of streptococcal pyrogenic exotoxin J, a novel superantigen
    J K McCormick
    Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Infect Immun 69:1381-8. 2001
    ..The characterization of a seventh functional streptococcal PTSAg raises important questions relating to the evolution of the streptococcal superantigens...
  82. ncbi Unique regulation of SclB - a novel collagen-like surface protein of Streptococcus pyogenes
    M Rasmussen
    Section for Molecular Pathogenesis, Department of Cell and Molecular Biology, Lund University, BMC, B14, Tornavagen 10, S 221 84 Lund, Sweden
    Mol Microbiol 40:1427-38. 2001
    ..pyogenes, downregulates sclB transcription. This observation and the potential of SclB to phase vary by slipped-strand mispairing emphasize the unique regulation of this novel S. pyogenes surface protein...
  83. ncbi Mutational and comparative analysis of streptolysin O, an oxygen-labile streptococcal hemolysin
    I Yamamoto
    Department of Biochemistry I, Fukui Medical University, Matsuoka, Japan
    Biosci Biotechnol Biochem 65:2682-9. 2001
    ..002% of the activity remained after deletion of the C-terminal four residues. Nucleotide replacement experiments indicated pivotal roles of I202, V217, D324-L325, V339, and H469 residues in hemolysis...
  84. pmc Superantigens and streptococcal toxic shock syndrome
    Thomas Proft
    Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Emerg Infect Dis 9:1211-8. 2003
  85. ncbi Identification of superantigen genes speM, ssa, and smeZ in invasive strains of beta-hemolytic group C and G streptococci recovered from humans
    Emeka I Igwe
    Centers for Disease Control and Prevention, Respiratory Diseases Branch, 1600 Clifton Rd, Mailstop CO2, 30333, Atlanta, GA, USA
    FEMS Microbiol Lett 229:259-64. 2003
    ..dysgalactiae subsp. equisimilis and S. canis with identical or near-identical sequences to their counterparts in S. pyogenes suggests frequent interspecies gene exchange between the three beta-hemolytic streptococcal species...
  86. pmc Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection
    Fiona C McKay
    Department of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
    Infect Immun 72:364-70. 2004
    ..Despite considerable amino acid sequence variation within the A1 repeat region of PAM where the plasminogen-binding domain maps, the critical lysine residue was conserved...
  87. ncbi Crystal structure of a phosphotransacetylase from Streptococcus pyogenes
    Qian Steven Xu
    Berkeley Structural Genomics Center, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Proteins 55:479-81. 2004
  88. ncbi Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected]
    Tanis Hogg
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 117:57-68. 2004
    ..Reciprocal regulation of the antagonistic catalytic activities, suggested by the structure, is supported by mutagenesis experiments and appears to involve ligand-induced signal transmission between the two active sites...
  89. ncbi Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response
    Nobuyuki Yoshizawa
    Department of Public Health, National Defense Medical College, Saitama, Japan
    J Am Soc Nephrol 15:1785-93. 2004
    ..Moreover, antibody titers remained elevated during the entire 10-yr follow-up period...
  90. ncbi Crystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and dimerization
    Heather M Baker
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Biol Chem 279:38571-6. 2004
    ..We infer that SPE-J cross-links TCR and MHC-II as a monomer but that dimers may form on the antigen-presenting cell surface, cross-linking MHC-II and eliciting intracellular signaling...
  91. pmc Molecular characterization of CcpA and involvement of this protein in transcriptional regulation of lactate dehydrogenase and pyruvate formate-lyase in the ruminal bacterium Streptococcus bovis
    Narito Asanuma
    Department of Life Science, College of Agriculture, Meiji University, Higashimita, Tama ku, Kawasaki 214 8571, Japan
    Appl Environ Microbiol 70:5244-51. 2004
    ..Thus, CcpA appears to be involved in the global regulation of sugar utilization in S. bovis...
  92. ncbi Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae
    Kazuhiko Maeda
    Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Microbes Infect 6:1163-70. 2004
    ..These results suggest that GAPDHs of various plaque-forming streptococci may be involved in their attachment to P. gingivalis fimbriae and that they may contribute to P. gingivalis colonization...
  93. ncbi Attribution of the various inhibitory actions of the streptococcal inhibitor of complement (SIC) to regions within the molecule
    Michael J Binks
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Biol Chem 280:20120-5. 2005
    ..a) SRR alone was sufficient to confer inhibition of complement function. (b) Anti-defensin and anti-lysozyme activities were mapped to the SRR plus LRR. (c) The LRR plus PRR harbored ezrin binding activity...
  94. pmc Evolution of transcription regulatory genes is linked to niche specialization in the bacterial pathogen Streptococcus pyogenes
    Debra E Bessen
    Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA
    J Bacteriol 187:4163-72. 2005
    ....
  95. ncbi Identification and characterization of a novel fibronectin-binding protein gene from Streptococcus equi subspecies zooepidemicus strain VTU211
    Kyongsu Hong
    Laboratories for Bioengineering and Research, JCR Pharmaceuticals Co, Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    FEMS Immunol Med Microbiol 45:231-7. 2005
    ..Purified FNZ2(2-4) protein was also shown to display collagen-binding activity to collagen-coated microtiter wells. These results show that recombinant FNZ2 has fibronectin- and collagen-binding activities...
  96. ncbi Species identification of mutans streptococci by groESL gene sequence
    Wei Chung Hung
    Department of Clinical Laboratory Sciences and Medical Biotechnology, Center for Optoelectronic Biomedicine and Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Med Microbiol 54:857-62. 2005
    ....
  97. pmc Crystal structures of delta1-pyrroline-5-carboxylate reductase from human pathogens Neisseria meningitides and Streptococcus pyogenes
    B Nocek
    Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, 9700 South Cass Avenue, Building 202, Argonne, IL 60439, USA
    J Mol Biol 354:91-106. 2005
    ..The inhibitory L-proline has been observed in the crystal structure...
  98. pmc Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix
    Nicola L Smith
    Chemical Biology Research Group, School of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, United Kingdom
    Proc Natl Acad Sci U S A 102:17652-7. 2005
    ....
  99. ncbi Unusual structural features of the bacteriophage-associated hyaluronate lyase (hylp2)
    Parul Mishra
    Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226 001, India
    J Biol Chem 281:7143-50. 2006
    ....
  100. ncbi Crystal structure of group A streptococcus Mac-1: insight into dimer-mediated specificity for recognition of human IgG
    Johnson Agniswamy
    Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA
    Structure 14:225-35. 2006
    ..A tunnel observed at the dimer interface constitutes a target for designing potential Mac-1-specific antimicrobial agents. The structures also offer insight into the functional difference between Mac-1 and Mac-2...
  101. ncbi D-Ribulose 5-phosphate 3-epimerase: functional and structural relationships to members of the ribulose-phosphate binding (beta/alpha)8-barrel superfamily
    Julie Akana
    Department of Biochemistry, University of Illinois at Urbana Champaign, 600 S Mathews Avenue, Urbana, Illinois 61801, USA
    Biochemistry 45:2493-503. 2006
    ..Instead, this "superfamily" may result from assembly from smaller modules, including the conserved phosphate binding motif associated with the C-terminal (beta/alpha)(2)-quarter barrel...

Research Grants4

  1. EVOLUTION OF GROUP A STREPTOCOCCI
    DEBRA BESSEN; Fiscal Year: 2004
    ..These sera will be tested to determine whether strain structure is determined by the immunogenicity of the emm and sof gene products. ..
  2. Molecular Evolution of Resistance in Strep. pyogenes
    DEBRA BESSEN; Fiscal Year: 2005
    ..GAS provide a sound model system for understanding the molecular evolution underlying the early stages of the emergence and global spread of antibiotic resistance. ..
  3. Tissue-Specific Infection by Group A Streptococci
    DEBRA BESSEN; Fiscal Year: 2007
    ..A better understanding of the molecular basis for throat- and skin-specific infection might aid in the development of vaccines which target essential adaptive traits and thereby, break the chain of transmission. ..
  4. Population genomics of Streptococcus pyogenes
    DEBRA BESSEN; Fiscal Year: 2009
    ..abstract_text> ..

Patents15

  1. METHODS FOR PRODUCING GENETIC MODIFICATIONS IN A PLANT GENOME WITHOUT INCORPORATING A SELECTABLE TRANSGENE MARKER, AND COMPOSITIONS THEREOF
    Patent Number: WO2015026886-A1; Date:2015-02-26
  2. PLANT GENOME MODIFICATION USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS AND METHODS OF USE
    Patent Number: WO2015026883-A1; Date:2015-02-26
  3. A SOYBEAN U6 POLYMERASE III PROMOTER AND METHODS OF USE
    Patent Number: WO2015026887-A1; Date:2015-02-26
  4. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  5. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  6. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  7. Lipid metabolism proteins, combinations of lipid metabolism proteins and uses thereof
    Patent Number: WO2009077406-A1; Date:2009-06-25
  8. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  9. Plants with increased yield by increasing or generating one or more activities in a plant or a part thereof
    Patent Number: WO2010020654-A2; Date:2010-02-25
  10. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  11. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  12. HIGHLY CONSERVED GENES AND THEIR USE TO GENERATE SPECIES-SPECIFIC, GENUS-SPECIFIC, FAMILY-SPECIFIC, GROUP-SPECIFIC AND UNIVERSAL NUCLEIC ACID PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY ALGAL, ARCHAEAL, BACTERIAL, FUNGAL AND PARASITICAL MICROOR-GANISMS FROM CLINICAL SPECIMENS FOR DIAGNOSIS
    Patent Number: JP2003511015-A; Date:2003-03-25
  13. STRUCTURE-BASED COMPOUND DESIGN INVOLVING RIBOSWITCHES
    Patent Number: JP2012065661-A; Date:2012-04-05
  14. RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES
    Patent Number: KR1020130117753-A; Date:2013-10-28
  15. STRUCTURE-BASED COMPOUND DESIGN INVOLVING RIBOSWITCHES
    Patent Number: JP2008518630-A; Date:2008-06-05