Streptococcus mutans UA159

Summary

Alias: Streptococcus mutans str. UA159

Top Publications

  1. pmc Characterization and sequence analysis of the scrA gene encoding enzyme IIScr of the Streptococcus mutans phosphoenolpyruvate-dependent sucrose phosphotransferase system
    Y Sato
    Department of Microbiology Immunology, Northwestern University Medical Dental Schools, Chicago, Illinois 60611
    J Bacteriol 171:263-71. 1989
  2. ncbi Sequence analysis of the gtfC gene from Streptococcus mutans GS-5
    S Ueda
    Department of Microbiology Immunology, Northwestern University Medical and Dental Schools, Chicago, IL 60611
    Gene 69:101-9. 1988
  3. pmc Sequence analysis of the gtfB gene from Streptococcus mutans
    T Shiroza
    J Bacteriol 169:4263-70. 1987
  4. pmc Molecular characterization of a STreptococcus mutans mutant altered in environmental stress responses
    Y Yamashita
    Department of Preventive Dentistry, Kyushu Dental College, Kitakyushu, Japan
    J Bacteriol 175:6220-8. 1993
  5. pmc Role of the citrate pathway in glutamate biosynthesis by Streptococcus mutans
    D G Cvitkovitch
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, USA
    J Bacteriol 179:650-5. 1997
  6. pmc Cloning and sequence analysis of the gbpC gene encoding a novel glucan-binding protein of Streptococcus mutans
    Y Sato
    Department of Biochemistry, Tokyo Dental College, Chiba City, Japan
    Infect Immun 65:668-75. 1997
  7. pmc Identification of a homolog of CcpA catabolite repressor protein in Streptococcus mutans
    C L Simpson
    Department of Oral Biology, The Dental School, University of Newcastle upon Tyne, United Kingdom
    Infect Immun 66:2085-92. 1998
  8. ncbi Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved in resistance to acid stress
    J A Gutierrez
    Department of Oral Biology, University of Florida, Gainesville 32610, USA
    Microbiology 145:357-66. 1999
  9. pmc Regulation of expression of the fructan hydrolase gene of Streptococcus mutans GS-5 by induction and carbon catabolite repression
    R A Burne
    Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bacteriol 181:2863-71. 1999
  10. ncbi Construction of region-specific partial duplication mutants (merodiploid mutants) to identify the regulatory gene for the glucan-binding protein C gene in vivo in Streptococcus mutans
    Y Sato
    Oral Health Science Center, Tokyo Dental College, 2 2, Masago 1 chome, Mihama ku, Chiba City, Japan
    FEMS Microbiol Lett 186:187-91. 2000

Patents

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  6. Process for the production of lutein
  7. Plants with increased yield by increasing or generating one or more activities in a plant or a part thereof
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  9. Reduced colonization of microbes at the mucosa
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Scientific Experts

Detail Information

Publications144 found, 100 shown here

  1. pmc Characterization and sequence analysis of the scrA gene encoding enzyme IIScr of the Streptococcus mutans phosphoenolpyruvate-dependent sucrose phosphotransferase system
    Y Sato
    Department of Microbiology Immunology, Northwestern University Medical Dental Schools, Chicago, Illinois 60611
    J Bacteriol 171:263-71. 1989
    ..mutans protein was also homologous with the Salmonella typhimurium enzyme IIIGlc and the 162-amino-acid C terminus of E. coli enzyme IIBgl. These results suggest that the sucrose PTS system of S. mutans is enzyme III independent...
  2. ncbi Sequence analysis of the gtfC gene from Streptococcus mutans GS-5
    S Ueda
    Department of Microbiology Immunology, Northwestern University Medical and Dental Schools, Chicago, IL 60611
    Gene 69:101-9. 1988
    ..The possible evolution of the gtfC gene in S. mutans GS-5 is also discussed...
  3. pmc Sequence analysis of the gtfB gene from Streptococcus mutans
    T Shiroza
    J Bacteriol 169:4263-70. 1987
    ..Nucleotide sequencing of the region immediately downstream from the gtfB gene revealed the presence of a putative gene coding for an extracellular protein. This open reading frame is partially homologous to the gtfB gene...
  4. pmc Molecular characterization of a STreptococcus mutans mutant altered in environmental stress responses
    Y Yamashita
    Department of Preventive Dentistry, Kyushu Dental College, Kitakyushu, Japan
    J Bacteriol 175:6220-8. 1993
    ..These results suggest that the S. mutans homolog of diacylglycerol kinase is important for adaptation of the organism to several environmental stress signals...
  5. pmc Role of the citrate pathway in glutamate biosynthesis by Streptococcus mutans
    D G Cvitkovitch
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, USA
    J Bacteriol 179:650-5. 1997
    ..Indeed, S. mutans JH1005 was shown to assimilate ammonia as a sole source of nitrogen in minimal medium devoid of organic nitrogen sources...
  6. pmc Cloning and sequence analysis of the gbpC gene encoding a novel glucan-binding protein of Streptococcus mutans
    Y Sato
    Department of Biochemistry, Tokyo Dental College, Chiba City, Japan
    Infect Immun 65:668-75. 1997
    ..Extract from an E. coli clone of the gene exhibited glucan-binding activity. Therefore, the gene encoded a novel glucan-binding protein...
  7. pmc Identification of a homolog of CcpA catabolite repressor protein in Streptococcus mutans
    C L Simpson
    Department of Oral Biology, The Dental School, University of Newcastle upon Tyne, United Kingdom
    Infect Immun 66:2085-92. 1998
    ..These results suggest that while RegM can affect catabolite repression in S. mutans, it does not conform to the model proposed for CcpA in Bacillus subtilis...
  8. ncbi Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved in resistance to acid stress
    J A Gutierrez
    Department of Oral Biology, University of Florida, Gainesville 32610, USA
    Microbiology 145:357-66. 1999
    ..These findings suggest that Ffh may be involved in the maintenance of a functional membrane protein composition during adaptation of S. mutans to changing environmental conditions...
  9. pmc Regulation of expression of the fructan hydrolase gene of Streptococcus mutans GS-5 by induction and carbon catabolite repression
    R A Burne
    Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bacteriol 181:2863-71. 1999
    ....
  10. ncbi Construction of region-specific partial duplication mutants (merodiploid mutants) to identify the regulatory gene for the glucan-binding protein C gene in vivo in Streptococcus mutans
    Y Sato
    Oral Health Science Center, Tokyo Dental College, 2 2, Masago 1 chome, Mihama ku, Chiba City, Japan
    FEMS Microbiol Lett 186:187-91. 2000
    ..The 690-bp gene responsible for the ddag(-) phenotype was identified within a 60-kb region by observing ddag (positive or negative) phenotypes of successively constructed specific duplication mutants...
  11. ncbi A novel beta-glucoside-specific PTS locus from Streptococcus mutans that is not inhibited by glucose
    C K Cote
    Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    Microbiology 146:1555-63. 2000
    ..When a plasmid containing the 8 kb beta-glucoside-specific regulon was transformed into E. coli CC118, the transformed strain was able to break down the beta-glucoside arbutin...
  12. pmc Natural genetic transformation of Streptococcus mutans growing in biofilms
    Y H Li
    Dental Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1G6
    J Bacteriol 183:897-908. 2001
    ..This work demonstrated that a peptide pheromone system controls genetic competence in S. mutans and that the system functions optimally when the cells are living in actively growing biofilms...
  13. ncbi Characterization of two operons that encode components of fructose-specific enzyme II of the sugar:phosphotransferase system of Streptococcus mutans
    Z T Wen
    Department of Oral Biology, University of Florida, College of Dentistry, P O Box 100424, Gainesville, FL 32610, USA
    FEMS Microbiol Lett 205:337-42. 2001
    ..Xylitol toxicity assays indicated that the inducible fructose permease was responsible for xylitol transport...
  14. pmc Functional genomics approach to identifying genes required for biofilm development by Streptococcus mutans
    Zezhang T Wen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Appl Environ Microbiol 68:1196-203. 2002
    ..From these data, we conclude that CcpA and BrpA may regulate genes that are required for stable biofilm formation by S. mutans...
  15. pmc Analysis of an agmatine deiminase gene cluster in Streptococcus mutans UA159
    Ann R Griswold
    Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
    J Bacteriol 186:1902-4. 2004
    ..encoding enzymes of the agmatine deiminase system (AgDS) has been identified in the cariogenic bacterium Streptococcus mutans UA159. The AgDS is regulated by agmatine induction and carbohydrate catabolite repression...
  16. ncbi RegM is required for optimal fructosyltransferase and glucosyltransferase gene expression in Streptococcus mutans
    Christopher M Browngardt
    Department of Oral Biology, College of Dentistry, University of Florida, 1600 SW Archer Road, P O Box 100424, Gainesville, FL 32610 0424, USA
    FEMS Microbiol Lett 240:75-9. 2004
    ..These findings reinforce the importance of pH and carbohydrate availability for expression of two primary virulence attributes of S. mutans and reveal a critical role for RegM in regulation of expression of both gtfBC and ftf...
  17. pmc Trigger factor in Streptococcus mutans is involved in stress tolerance, competence development, and biofilm formation
    Zezhang T Wen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Infect Immun 73:219-25. 2005
    ..These results suggest that RopA is a key regulator of acid and oxidative stress tolerance, genetic competence, and biofilm formation, all critical virulence properties of S. mutans...
  18. pmc Role of HtrA in growth and competence of Streptococcus mutans UA159
    Sang Joon Ahn
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Bacteriol 187:3028-38. 2005
    ....
  19. pmc Identification and characterization of an autolysin-encoding gene of Streptococcus mutans
    Yukie Shibata
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Infect Immun 73:3512-20. 2005
    ..mutans. These results indicate that the catalytic domain of AtlA is located at the C terminus, suggesting that further characterization of this domain may provide a means to control cariogenic dental plaque formation...
  20. pmc Structure-activity analysis of quorum-sensing signaling peptides from Streptococcus mutans
    Raymond T Syvitski
    College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada
    J Bacteriol 189:1441-50. 2007
    ..This study is the first study to recognize the importance of the signaling peptide C-terminal residues in streptococcal quorum sensing...
  21. pmc Regulation of gbpC expression in Streptococcus mutans
    Indranil Biswas
    Basic Biomedical Sciences, University of South Dakota, Lee Medical Building, 414 E Clark Street, Vermillion, SD 57069, USA
    J Bacteriol 189:6521-31. 2007
    ..In summary, our results indicate that various stress conditions modulate the expression of gbpC and that CovR negatively regulates the expression of the gbpC gene by directly binding to the promoter region...
  22. pmc Autoinducer-2-regulated genes in Streptococcus mutans UA159 and global metabolic effect of the luxS mutation
    Helena Sztajer
    Helmholtz Center for Infection Research, Division of Cell Biology, Inhoffenstr 7, D 38124 Braunschweig, Germany
    J Bacteriol 190:401-15. 2008
    ..signaling role of AI-2, we carried out a global transcriptome analysis of a luxS null mutant culture of Streptococcus mutans UA159, an important cariogenic bacterium and a crucial component of the dental plaque biofilm community, in ..
  23. pmc CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans
    Jacqueline Abranches
    Department of Oral Biology, University of Florida College of Dentistry, P O Box 100424, Gainesville, FL 32610, USA
    J Bacteriol 190:2340-9. 2008
    ..5, and could acidify the environment more rapidly and to a greater extent than the parental strain. Thus, CcpA directly modulates the pathogenic potential of S. mutans through global control of gene expression...
  24. doi SloR modulation of the Streptococcus mutans acid tolerance response involves the GcrR response regulator as an essential intermediary
    Daniel W Dunning
    Department of Biology, Middlebury College, Middlebury, VT 05753, USA
    Microbiology 154:1132-43. 2008
    ..Taking these results together, we propose that SloR-Mn modulates S. mutans gcrR expression as part of a general stress response, and that GcrR acts downstream of SloR to control the ATR...
  25. doi Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex
    Cong Liu
    National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    J Mol Biol 379:73-81. 2008
    ....
  26. pmc Modulation of covR expression in Streptococcus mutans UA159
    Patrick Chong
    Department of Microbiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Bacteriol 190:4478-88. 2008
    ..A detailed analysis of the regulation of CovR may lead to a better understanding of the pathogenesis of S. mutans, as well as providing further insight into the prevention of dental caries...
  27. pmc Characterization of irvR, a novel regulator of the irvA-dependent pathway required for genetic competence and dextran-dependent aggregation in Streptococcus mutans
    Guoqing Niu
    Department of Oral Biology, College of Dentistry, University of Oklahoma Health Sciences Center BRC364, 975 NE 10th St, Oklahoma City, OK 73104 5419, USA
    J Bacteriol 190:7268-74. 2008
    ..These data indicate that the repression of irvA is critically dependent upon irvR and that irvA repression is essential for the development of genetic competence and the proper control of DDAG in S. mutans...
  28. pmc ClpP of Streptococcus mutans differentially regulates expression of genomic islands, mutacin production, and antibiotic tolerance
    Partho Chattoraj
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    J Bacteriol 192:1312-23. 2010
    ..The results presented here indicate that ClpP-mediated proteolysis plays an important global role in the regulation of several important traits in this pathogen...
  29. pmc Downregulation of GbpB, a component of the VicRK regulon, affects biofilm formation and cell surface characteristics of Streptococcus mutans
    Cristiane Duque
    Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas UNICAMP, Av Limeira 901, CEP 13414 903 Piracicaba, Sao Paulo, Brazil
    Infect Immun 79:786-96. 2011
    ..These data provide the first experimental evidence for GbpB participation in sucrose-dependent biofilm formation and in cell surface properties...
  30. pmc Activation of the SMU.1882 transcription by CovR in Streptococcus mutans
    Patrick Chong
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
    PLoS ONE 5:e15528. 2010
    ..mutans RpoD, E. coli RNA polymerase, and CovR did not activate transcription from this promoter. Thus, we speculate that in vivo, CovR may interfere with the binding of a repressor or requires a cofactor...
  31. pmc A transcriptional regulator and ABC transporters link stress tolerance, (p)ppGpp, and genetic competence in Streptococcus mutans
    Kinda Seaton
    Department of Oral Biology, University of Florida, College of Dentistry, Gainesville, FL 32610, USA
    J Bacteriol 193:862-74. 2011
    ..Collectively, the data support the suggestion that the rcrRPQ gene products play a critical role in physiologic homeostasis and stress tolerance by linking (p)ppGpp metabolism, acid and oxidative stress tolerance, and genetic competence...
  32. pmc Characterization of DNA binding sites of the ComE response regulator from Streptococcus mutans
    David C I Hung
    Department of Molecular and Computational Biology, Division of Biomedical Science, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California 90089 0641, USA
    J Bacteriol 193:3642-52. 2011
    ..Based on the mutational analysis and DNase I footprinting analysis, we propose a consensus ComE binding site, TCBTAAAYSGT...
  33. pmc Identification of the Streptococcus mutans LytST two-component regulon reveals its contribution to oxidative stress tolerance
    Sang Joon Ahn
    Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32611, USA
    BMC Microbiol 12:187. 2012
    ..In this study, we sought to determine if LytST was involved in regulating lrgAB expression in response to glucose and oxygenation in S. mutans...
  34. pmc MecA protein acts as a negative regulator of genetic competence in Streptococcus mutans
    Xiao Lin Tian
    Department of Applied Oral Sciences
    J Bacteriol 195:5196-206. 2013
    ..mutans. Together, our data support the notion that MecA mediates the formation of a ternary SigX-MecA-ClpC complex that sequesters SigX and thereby negatively regulates genetic competence in S. mutans. ..
  35. pmc Sequence analysis of the Streptococcus mutans fructosyltransferase gene and flanking regions
    T Shiroza
    Department of Microbiology Immunology, Northwestern University Medical Dental Schools, Chicago, Illinois 60611
    J Bacteriol 170:810-6. 1988
    ..In addition, ORF 3 is transcribed from the ftf DNA coding strand. Partial sequencing of ORF 4 suggests that its gene product may be an extracellular protein...
  36. pmc LuxS-mediated signaling in Streptococcus mutans is involved in regulation of acid and oxidative stress tolerance and biofilm formation
    Zezhang T Wen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    J Bacteriol 186:2682-91. 2004
    ..This study demonstrates that luxS-dependent signaling plays critical roles in modulating key virulence properties of S. mutans...
  37. pmc Influence of BrpA on critical virulence attributes of Streptococcus mutans
    Zezhang T Wen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    J Bacteriol 188:2983-92. 2006
    ..mutans, which are key virulence attributes of the organism...
  38. pmc Effects of oxygen on biofilm formation and the AtlA autolysin of Streptococcus mutans
    Sang Joon Ahn
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Bacteriol 189:6293-302. 2007
    ..This study illustrates the central role of AtlA and VicK in orchestrating growth on surfaces and envelope biogenesis in response to redox conditions...
  39. pmc Regulation of ciaXRH operon expression and identification of the CiaR regulon in Streptococcus mutans
    Chenggang Wu
    College of Dentistry, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Bacteriol 192:4669-79. 2010
    ..Taken together, we conclude that overexpressed CiaR, as a result of either ciaH deletion or forced expression from a constitutive promoter, is a mediator in the CiaH-regulated phenotypes...
  40. ncbi In vitro effects of crude khat extracts on the growth, colonization, and glucosyltransferases of Streptococcus mutans
    Nezar Noor Al-Hebshi
    Department of Oral Sciences Oral Microbiology, Faculty of Dentistry, University of Bergen, Norway
    Acta Odontol Scand 63:136-42. 2005
    ..Sucrose-dependent colonization was assessed as the ability of Streptococcus mutans UA159 to form adherent biofilms in glass culture tubes...
  41. ncbi Influence of cranberry juice on glucan-mediated processes involved in Streptococcus mutans biofilm development
    H Koo
    Center for Oral Biology and Eastman Department of Dentistry, 601 Elmwood Avenue, Box 611, University of Rochester Medical Center, Rochester, NY 14642, USA
    Caries Res 40:20-7. 2006
    ..5) on several activities in vitro associated with the development of Streptococcus mutans UA159 biofilms. The ability of CJ to influence the adherence of S...
  42. doi Role of two component signaling response regulators in acid tolerance of Streptococcus mutans
    M Kawada-Matsuo
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Higashi ku, Fukuoka, Japan
    Oral Microbiol Immunol 24:173-6. 2009
    ..Fourteen hk-rr homologs and one orphan rr homolog were identified in the Streptococcus mutans UA159 genome database...
  43. pmc Genetic adaptation of Streptococcus mutans during biofilm formation on different types of surfaces
    Moshe Shemesh
    Biofilm Research Laboratory, Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University Hadassah POB 12272, Jerusalem 91120, Israel
    BMC Microbiol 10:51. 2010
    ..The aim of the study was to investigate the molecular modifications occurring during in vitro biofilm development of Streptococcus mutans UA159 on several different dental surfaces.
  44. ncbi Inhibition of bacterial adherence to saliva-coated through plant lectins
    Mara R T R Oliveira
    Department of Physiologic Sciences, Piracicaba Dental School, State University of Campinas, SP, Brazil
    J Oral Sci 49:141-5. 2007
    ..and bactericidal concentrations of these proteins were determined using 5 species of bacteria: Streptococcus mutans UA159, Streptococcus sobrinus 6715, Streptococcus sanguinis ATCC10556, Streptococcus mitis ATCC903 and ..
  45. pmc Influence of apigenin on gtf gene expression in Streptococcus mutans UA159
    Hyun Koo
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, 625 Elmwood Ave, Box 683, Rochester, NY 14620, USA
    Antimicrob Agents Chemother 50:542-6. 2006
    ..The data show that apigenin modulates the genetic expression of virulence factors in S. mutans...
  46. pmc Tooth-binding micelles for dental caries prevention
    Fu Chen
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198 6025, USA
    Antimicrob Agents Chemother 53:4898-902. 2009
    ..the farnesol-containing tooth-binding micelles were able to provide significantly stronger inhibition of Streptococcus mutans UA159 biofilm formation on HA discs than the untreated blank control micelles (P < 0.0001)...
  47. ncbi Shifts in membrane fatty acid profiles associated with acid adaptation of Streptococcus mutans
    R G Quivey
    Center for Oral Biology, University of Rochester, New York 14642, USA
    FEMS Microbiol Lett 189:89-92. 2000
    Cells of Streptococcus mutans UA159 physiologically adapted to acidification during growth at pH 5 in glucose-limited chemostat cultures were enriched in mono-unsaturated and longer chain fatty acids compared with unadapted cells grown ..
  48. pmc Distribution, regulation and role of the agmatine deiminase system in mutans streptococci
    A R Griswold
    Department of Oral Biology, University of Florida, Gainesville, FL 32610 0424, USA
    Oral Microbiol Immunol 24:79-82. 2009
    ..the AgDS of Streptococcus rattus FA-1 were sequenced and found to share homology with the agu genes of Streptococcus mutans UA159. With the exception of Streptococcus sobrinus, the AgDS of mutans streptococci appear to be sensitive to ..
  49. pmc The chromosomal mazEF locus of Streptococcus mutans encodes a functional type II toxin-antitoxin addiction system
    Mohammad Adnan Syed
    Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada
    J Bacteriol 193:1122-30. 2011
    ..Bioinformatic analysis of Streptococcus mutans UA159 genome identified a pair of linked genes encoding a MazEF-like TA. Our results show that S...
  50. doi Characterization of an antimicrobial dental resin adhesive containing zinc methacrylate
    Sandrina Henn
    Department of Operative Dentistry, CDC Bio, School of Dentistry, Federal University of Pelotas, Rua Gonçalves Chaves, 457, Pelotas, RS, 96015 560, Brazil
    J Mater Sci Mater Med 22:1797-802. 2011
    ..An MTT assay was used to access the cytotoxicity. The AA against Streptococcus mutans UA159 was accessed by the agar diffusion method...
  51. pmc Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition
    P Matthew Joyner
    Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, OK 73019, USA
    Org Biomol Chem 8:5486-9. 2010
    The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress ..
  52. ncbi [The inhibition effect of recombinant Streptococcus mutans JH1140 containing urease gene on Streptococcus mutans UA159]
    Xin Rui
    Department of Preventive Dentistry, College of Stomatology, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
    Shanghai Kou Qiang Yi Xue 19:281-4. 2010
    To study the effect of mutacin of recombinant Streptococcus mutans JH1140 against Streptococcus mutans UA159.
  53. ncbi Sequencing and characterization of the 185 kDa cell surface antigen of Streptococcus mutans
    C Kelly
    Department of Immunology, United Medical School, Guy s Hospital, London, England
    Arch Oral Biol 35:33S-38S. 1990
    ..N-terminal sequencing of purified antigens I and II components indicated that antigen I extends from the amino-terminus of the intact Mr 185,000 surface antigen while antigen II extends from residue 996...
  54. ncbi Sequence analysis of the wall-associated protein precursor of Streptococcus mutans antigen A
    J J Ferretti
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City 73190
    Mol Microbiol 3:469-78. 1989
    ..Thus, the wall-associated protein A is a precursor of the 29,000 Mr antigen A...
  55. pmc Streptococcus mutans gtfA gene specifies sucrose phosphorylase
    R R Russell
    Royal College of Surgeons of England, Downe, Kent, United Kingdom
    Infect Immun 56:2763-5. 1988
    ..The product was identified as alpha-D-glucose-1-phosphate, and it was concluded that the GTF-A enzyme is sucrose phosphorylase (sucrose:orthophosphate alpha-D-glucosyltransferase [EC 2.4.1.7])...
  56. ncbi Regulation of ptsH and ptsI gene expression in Streptococcus salivarius ATCC 25975
    G Gagnon
    Département de Biochimie Sciences, Universite Laval, Quebec, Canada
    Mol Microbiol 16:1111-21. 1995
    ..Studies with a 2-deoxyglucose-resistant spontaneous mutant of S. salivarius (L26) that produces an HPr-EI fusion protein suggest that the regulation of HPr and EI expression involves transcriptional as well as translational mechanisms...
  57. ncbi Organization and nucleotide sequence of the Streptococcus mutans galactose operon
    D Ajdic
    Department of Microbiology and Immunology, University of Oklahoma, Oklahoma City 73104, USA
    Gene 180:137-44. 1996
    ..Evidence is presented that galactose transport is independent of the proton motive force and may be ATP-dependent...
  58. pmc Diacylglycerol kinase is involved in regulation of expression of the lantibiotic mutacin II of Streptococcus mutans
    P Chen
    Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, 35294, USA
    J Bacteriol 180:167-70. 1998
    ..These data indicated that the full-length dgk gene product along with the mutacin biosynthetic operon are required for the production of the mutacin II lantibiotic...
  59. ncbi Biological functions of UDP-glucose synthesis in Streptococcus mutans
    Y Yamashita
    Department of Preventive Dentistry, Kyushu University Faculty of Dentistry, Fukuoka, Japan
    Microbiology 144:1235-45. 1998
    ..mutans (as a glucose donor for side-chain formation), but is also important for the organism's viability in environmental conditions of low pH...
  60. pmc Shifts in the membrane fatty acid profile of Streptococcus mutans enhance survival in acidic environments
    Elizabeth M Fozo
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Appl Environ Microbiol 70:929-36. 2004
    Acid adaptation of Streptococcus mutans UA159 involves several different mechanisms, including the ability to alter its proportion of long-chain, monounsaturated membrane fatty acids (R. G. Quivey, Jr., R. Faustoferri, K. Monahan, and R...
  61. ncbi The influence of a novel propolis on mutans streptococci biofilms and caries development in rats
    Simone Duarte
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, NY 14620, USA
    Arch Oral Biol 51:15-22. 2006
    ..The effects of EEP and EEH on Streptococcus mutans UA159 and Streptococcus sobrinus 6715 biofilms were analysed by time-kill and glycolytic pH drop assays...
  62. pmc The erm(T) gene is flanked by IS1216V in inducible erythromycin-resistant Streptococcus gallolyticus subsp. pasteurianus
    Jui Chang Tsai
    Division of Neurosurgery, Department of Surgery, National Taiwan University College of Medicine, Taipei
    Antimicrob Agents Chemother 49:4347-50. 2005
    ..pasteurianus (formerly S. bovis biotype II.2) isolates. In all isolates, the erm(T) genes were flanked by two IS1216V-like elements with the same polarity and were found to be inserted in the chromosome...
  63. ncbi Genomic variation in Streptococcus mutans: deletions affecting the multiple pathways of beta-glucoside metabolism
    L A Old
    Oral Biology, School of Dental Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Oral Microbiol Immunol 21:21-7. 2006
    The genome of Streptococcus mutans UA159 contains two phospho-beta-glucosidase genes, bglA and celA, which occur in operon-like arrangements along with genes for components of phosphotransferase transport systems and a third phospho-beta-..
  64. pmc A eukaryotic-type serine/threonine protein kinase is required for biofilm formation, genetic competence, and acid resistance in Streptococcus mutans
    Haitham Hussain
    Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    J Bacteriol 188:1628-32. 2006
    ..Mutation of the gene encoding the STPK produced defects in biofilm formation, genetic competence, and acid resistance, determinants important in caries pathogenesis...
  65. pmc Transcriptional analysis of the bglP gene from Streptococcus mutans
    Christopher K Cote
    Department of Medical Microbiology and Immunology, University of South Florida, College of Medicine, Tampa, Florida 33612, USA
    BMC Microbiol 6:37. 2006
    ..It was hypothesized that antitermination is the regulatory mechanism that is responsible for the control of the bglP gene expression, which encodes an esculin-specific PTS enzyme II...
  66. pmc Invariant Thr244 is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans
    Arnaud Pailot
    MAEM, UMR 7567 Nancy Université, CNRS, Faculte des Sciences, 54506 Vandoeuvre Cedex, France
    Biochem J 400:521-30. 2006
    ....
  67. ncbi Three gene products govern (p)ppGpp production by Streptococcus mutans
    JOSE A LEMOS
    Department of Oral Biology, University of Florida College of Dentistry, PO Box 100424, Gainesville, FL 32610, USA
    Mol Microbiol 65:1568-81. 2007
    ....
  68. doi Antimicrobial properties of dentine bonding agents determined using in vitro and ex vivo methods
    M Vaidyanathan
    Dental Institute, King s College London, SE1 9RT, UK
    J Dent 37:514-21. 2009
    ..To determine the antimicrobial properties of a selection of dentine bonding agents [DBAs] using the disc diffusion and direct contact methods and an ex vivo method using extracted carious permanent molar teeth...
  69. pmc Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans
    Chao Pei Liu
    Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, People s Republic of China
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:498-502. 2010
    ..The structural symmetry of the sulfate-binding sites and the missing loops in this structure are consistent with a symmetric catalysis mechanism...
  70. doi Synthesis, antimicrobial and antiproliferative activity of novel silver(I) tris(pyrazolyl)methanesulfonate and 1,3,5-triaza-7-phosphadamantane complexes
    Claudio Pettinari
    School of Pharmacy, Universita degli Studi di Camerino, Via S Agostino 1, 62032 Camerino MC, Italy
    Inorg Chem 50:11173-83. 2011
    ..e., 3 > 2 > 1 > 5 > agno(3)≫ 4...
  71. pmc Structural identities of four glycosylated lipids in the oral bacterium Streptococcus mutans UA159
    Larry Sallans
    Department of Chemistry, University of Cincinnati, Cincinnati, OH, 45221, USA Electronic address
    Biochim Biophys Acta 1831:1239-49. 2012
    ..All sugars were shown to have α-glycosidic linkages and DGMAG was shown to be acylated in the sn-1 position by NMR. This is the first observation of unsubstituted DGMAG in any organism and the first mass spectrometry data for GPDGDAG...
  72. pmc Site-directed mutations in the lanthipeptide mutacin 1140
    Shaorong Chen
    Department of Biological Sciences, Texas A and M University, College Station, TX, USA
    Appl Environ Microbiol 79:4015-23. 2013
    ..MICs against Streptococcus mutans UA159, Streptococcus pneumoniae ATCC 27336, Staphylococcus aureus ATCC 25923, Clostridium difficile UK1, and ..
  73. doi Structural investigation of an extracellular polysaccharide produced by the cariogenic bacterium Streptococcus mutans strain UA159
    Bo Li
    School of Food Science, Henan Institute of Science and Technology, Hualan Road, 453003 Xinxiang, China
    Carbohydr Polym 90:675-82. 2012
    The structure of an extracellular polysaccharide EPS159 produced from sucrose by Streptococcus mutans UA159 was investigated through the main oligosaccharides obtained from partial acid hydrolysis, monosaccharide/methylation analysis, and ..
  74. pmc Proteome analysis identifies the Dpr protein of Streptococcus mutans as an important factor in the presence of early streptococcal colonizers of tooth surfaces
    Akihiro Yoshida
    Department of Oral Microbiology, Matsumoto Dental University, Shiojiri, Japan Division of Community Oral Health Science, Department of Oral Health Promotion, Kyushu Dental University, Kitakyushu, Japan
    PLoS ONE 10:e0121176. 2015
    ..gordonii. Therefore, these results suggest that Dpr might be one of the essential proteins for S. mutans survival on teeth in the presence of early colonizing oral streptococci. ..
  75. pmc Characterization of Streptococcus mutans strains deficient in EIIAB Man of the sugar phosphotransferase system
    Jacqueline Abranches
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida 32610, USA
    Appl Environ Microbiol 69:4760-9. 2003
    ..The role of EIIAB(Man) (encoded by manL) in gene regulation and sugar transport was investigated in Streptococcus mutans UA159. The manL knockout strain, JAM1, grew more slowly than the wild-type strain in glucose but grew faster ..
  76. pmc Regulation and physiologic significance of the agmatine deiminase system of Streptococcus mutans UA159
    Ann R Griswold
    Department of Oral Biology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0424, USA
    J Bacteriol 188:834-41. 2006
    ..The capacity to detoxify and catabolize agmatine is likely to have major ramifications on oral biofilm ecology...
  77. pmc Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159
    Sang Joon Ahn
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    Infect Immun 74:1631-42. 2006
    ..mutans isolates and between S. mutans and Streptococcus pneumoniae, indicating that substantial divergence in the role and regulation of TCS and competence genes has occurred in streptococci...
  78. pmc GH1-family 6-P-β-glucosidases from human microbiome lactic acid bacteria
    Karolina Michalska
    Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Argonne, Illinois, USA
    Acta Crystallogr D Biol Crystallogr 69:451-63. 2013
    ..mutans enzyme (E375Q), the structure of a 6'-P-salicin complex has also been determined. The presence of natural ligands enabled the definition of the structural elements that are responsible for substrate recognition during catalysis...
  79. pmc CovR-controlled global regulation of gene expression in Streptococcus mutans
    Alexander Dmitriev
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 6:e20127. 2011
    ..Our results indicate that CovR truly plays a significant role in the regulation of several virulence related traits in this pathogenic streptococcus...
  80. doi The global impact of the delta subunit RpoE of the RNA polymerase on the proteome of Streptococcus mutans
    Xiaoli Xue
    Research Group Microbial Communication, Division of Cell Biology, Helmholtz Centre for Infection Research, Inhoffenstr 7, D 38124 Braunschweig, Germany
    Microbiology 158:191-206. 2012
    ..The data are consistent with the reduced transcriptional specificity of the RNA polymerase in the ΔrpoE mutant, and suggest a general impact, but not a specific regulatory role, of RpoE in stress adaptation...
  81. pmc CtsR regulation in mcsAB-deficient Gram-positive bacteria
    Liang Tao
    Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
    J Bacteriol 194:1361-8. 2012
    ..We speculate that CtsR is regulated posttranslationally by a different mechanism in S. mutans and possibly in other streptococci...
  82. pmc Characterization of the functional domains of the SloR metalloregulatory protein in Streptococcus mutans
    Jeffrey R Haswell
    Middlebury College, Department of Biology, Middlebury, Vermont, USA
    J Bacteriol 195:126-34. 2013
    ..Given these results, we describe the functional domains of the S. mutans SloR protein and propose that the hyperactive mutant could serve as a target for rational drug design aimed at repressing SloR-mediated virulence gene expression...
  83. pmc Comprehensive mutational analysis of sucrose-metabolizing pathways in Streptococcus mutans reveals novel roles for the sucrose phosphotransferase system permease
    Lin Zeng
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USA
    J Bacteriol 195:833-43. 2013
    ..Sucrose-dependent catabolite repression was also evident in strains containing an intact sucrose PTS. Collectively, these results reveal a novel regulatory circuitry for the control of sucrose catabolism, with a central role for ScrA...
  84. ncbi A binding protein-dependent transport system in Streptococcus mutans responsible for multiple sugar metabolism
    R R Russell
    Department of Oral Biology, University of Newcastle upon Tyne, United Kingdom
    J Biol Chem 267:4631-7. 1992
    ..Insertional inactivation of each of these genes along with uptake data indicate that this system is responsible for the uptake of melibiose, raffinose, and isomaltotriose and the metabolism of melibiose, sucrose, and isomaltosaccharides...
  85. ncbi Biochemical and genetic analysis of Streptococcus mutans alpha-galactosidase
    J Aduse-Opoku
    Hunterian Dental Research Unit, London Hospital Medical College, UK
    J Gen Microbiol 137:757-64. 1991
    ..Inactivation of the aga gene in S. mutans resulted in loss of all alpha-galactosidase activity and abolished the ability to ferment melibiose; alpha-glucosidase activity was also lost, due to an indirect effect on the dexB gene...
  86. pmc DNA sequence and in vitro mutagenesis of the gene encoding the fructose-1,6-diphosphate-dependent L-(+)-lactate dehydrogenase of Streptococcus mutans
    M J Duncan
    Department of Molecular Genetics, Forsyth Dental Center, Boston, Massachusetts 02115
    Infect Immun 59:3930-4. 1991
    ..mutans was inserted at the deletion site as a marker for selection. In addition, evidence from Southern hybridization showed that S. mutans JH1000 contained a single copy of the lactate dehydrogenase gene...
  87. ncbi Nucleotide sequence of the asd gene of Streptococcus mutans. Identification of the promoter region and evidence for attenuator-like sequences preceding the structural gene
    G A Cardineau
    J Biol Chem 262:3344-53. 1987
    ..mutans asd gene in Escherichia coli suggesting the requirement of an accessory regulatory element specific for the S. mutans asd gene...
  88. ncbi Sequence analysis of the cloned streptococcal cell surface antigen I/II
    C Kelly
    Department of Immunology, United Medical School of Guy s Hospital, London, England
    FEBS Lett 258:127-32. 1989
    ..mutans serotype c. N-Terminal sequencing of separated antigen I and antigen II polypeptides suggests that the former represents the N-terminal and the latter the C-terminal portions of the intact antigen...
  89. ncbi Molecular characterization of a surface protein antigen gene from serotype c Streptococcus mutans, implicated in dental caries
    N Okahashi
    Department of Dental Research, National Institute of Health, Tokyo, Japan
    Mol Microbiol 3:673-8. 1989
    ....
  90. pmc Sequence, expression, and function of the gene for the nonphosphorylating, NADP-dependent glyceraldehyde-3-phosphate dehydrogenase of Streptococcus mutans
    D A Boyd
    Department of Oral Biology, University of Manitoba, Winnipeg, Canada
    J Bacteriol 177:2622-7. 1995
    ..mutans NG5 lacks both glucose-6-phosphate dehydrogenase and NADH:NADP oxidoreductase activities, the NADP-dependent glyceraldehyde-3-phosphate dehydrogenase is important as a means of generating NADPH for biosynthetic reactions...
  91. ncbi Molecular cloning and sequence analysis of the gene encoding the H2O2-forming NADH oxidase from Streptococcus mutans
    M Higuchi
    Research Center, Nippon Paint Co, Ltd, Osaka, Japan
    Biosci Biotechnol Biochem 58:1603-7. 1994
    ..6%, 20.8%, 20.3%, and 7.3% for those of Amphibacillus xylanus Ep01, Streptococcus faecalis 10C1, Thermoanaerobium brockii Rt8.G4, and Thermus thermophilus HB8, respectively...
  92. pmc A Streptococcus mutans mutant that synthesizes elevated levels of intracellular polysaccharide is hypercariogenic in vivo
    G Spatafora
    Department of Biology, Middlebury College, Vermont 05753, USA
    Infect Immun 63:2556-63. 1995
    ..The coordinate expression of GlgC and GlgA along with the results of ongoing nucleotide sequence analysis and Northern hybridization experiments support an operon-like arrangement for the glg genes of this oral pathogen...
  93. ncbi Insertional inactivation of the Streptococcus mutans dexA (dextranase) gene results in altered adherence and dextran catabolism
    S M Colby
    Department of Oral Biology, Dental School, University of Newcastle upon Tyne, UK
    Microbiology 141:2929-36. 1995
    ..The mutants were also more adherent to a smooth surface than LT11 but there was no apparent difference in sucrose-dependent cell-cell aggregation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  94. ncbi Sequence analysis of the Streptococcus mutans Ingbritt dexA gene encoding extracellular dextranase
    T Igarashi
    Department of Oral Microbiology, Showa University School of Dentistry, Tokyo, Japan
    Microbiol Immunol 39:853-60. 1995
    ..mutans and dextranase of S. sobrinus. The DexA protein had no significant homology with the glucosyltransferases, the glucan-binding protein, or the dextranase inhibitor of mutans streptococci...
  95. ncbi Molecular cloning and sequence analysis of the gene encoding the H2O-forming NADH oxidase from Streptococcus mutans
    J Matsumoto
    Research Center, Nippon Paint Co, Ltd, Osaka, Japan
    Biosci Biotechnol Biochem 60:39-43. 1996
    ..Comparisons with the NADH oxidase from Streptococcus faecalis 10C1 yield identities of 41%. The redox-active cysteine in the enzyme from S. faecalis was found to correspond to Cys 44 in the NOX-2...
  96. pmc Identification of a fourth gene involved in dTDP-rhamnose synthesis in Streptococcus mutans
    Y Tsukioka
    Department of Preventive Dentistry, Kyushu University Faculty of Dentistry, Fukuoka, Japan
    J Bacteriol 179:4411-4. 1997
    ..mutans. Furthermore, conservation of the rmlD gene in Streptococcus species was demonstrated by Southern blot analysis...
  97. ncbi Nucleotide sequence and molecular characterization of a gene encoding GTP-binding protein from Streptococcus gordonii
    S Kawabata
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Japan
    FEMS Microbiol Lett 156:211-6. 1997
    ..The nucleotide binding assay demonstrated that recombinant Sgg bound [32P]GTP but not [32P]ATP, [32P]CTP, or [32P]UTP. These findings indicate that Sgg is a member of the G protein superfamily in the genus Streptococcus...
  98. pmc The HPr(Ser) kinase of Streptococcus salivarius: purification, properties, and cloning of the hprK gene
    D Brochu
    GREB, Departement de Biochimie, Faculté des Sciences et de Génie and Faculté de Médecine Dentaire, GREB, Universite Laval, Ste Foy, Quebec, Canada G1K 7P4
    J Bacteriol 181:709-17. 1999
    ..salivarius is not stimulated by FDP or other glycolytic intermediates. The enzyme is inhibited by inorganic phosphate, and its Kms for HPr and ATP are 31 microM and 1 mM, respectively...
  99. ncbi Apo and holo crystal structures of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans
    D Cobessi
    Groupe Biocristallographie, ESA 7036 Faculté des Sciences, BP 239, Laboratoire de Cristallographie et Modélisation des Matériaux Minéraux et Biologiques, Vandoeuvre les Nancy, 54506, France
    J Mol Biol 290:161-73. 1999
    ..mutans ALDH. It was found that Arg103, Arg283 and Asp440 might be key residues for substrate binding...
  100. ncbi Tn917-lac mutagenesis of Streptococcus mutans to identify environmentally regulated genes
    D G Cvitkovitch
    University of Toronto Dental Research Institute, 124 Edward St, Toronto, Ont, Canada
    FEMS Microbiol Lett 182:149-54. 2000
    ..These findings demonstrate that Tn917-lac mutagenesis can be used to identify environmentally regulated genes in S. mutans and possibly in other medically relevant streptococcal species...
  101. pmc Role of the dpr product in oxygen tolerance in Streptococcus mutans
    Y Yamamoto
    Laboratory of Applied Microbiology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Amamiya Machi, Aoba ku, Sendai 981 8555, Japan
    J Bacteriol 182:3740-7. 2000
    ..The 20-kDa dpr gene product Dpr is an iron-binding protein. Synthesis of Dpr was induced by exposure of S. mutans cells to air. We propose a mechanism by which Dpr confers aerotolerance on S. mutans...

Research Grants8

  1. Degradation of Nanoscale Topography of Resin Restorations by Oral Biofilm Growth
    SHARUKH KHAJOTIA; Fiscal Year: 2009
    ....
  2. Effects of Natural Agents with Fluoride on Caries
    Hyun Koo; Fiscal Year: 2004
    ....
  3. Regulation of Streptococcus mutans Virulence by covR/S
    Grace Spatafora; Fiscal Year: 2003
    ..Taken collectively, these studies will elucidate S. mutans mechanism(s) of virulence gene control, and so enable prevention and/or intervention in the pathogenic process that leads to the development of Dental caries. ..
  4. LOW PH INDUCIBLE DNA REPAIR IN STREPTOCOCCUS MUTANS
    ROBERT QUIVEY; Fiscal Year: 2005
    ..mutans exonuclease, including a description of the genetic elements that participate in regulating synthesis of the enzyme and the protein(s) that function to regulate transcription of the exonuclease gene. ..
  5. Profiling of Redox-Sensitive Signaling Proteins
    Leslie Poole; Fiscal Year: 2006
    ..These tools will usher in a new era of redox proteomics and enable proteome-scale studies of effects of oxidative stress and antioxidant therapies on cell pathways and signaling networks. [unreadable] [unreadable] [unreadable]..
  6. ADAPTIVE ACID TOLERANCE OF STREPTOCOCCUS SOBRINUS
    JOSE LEMOS; Fiscal Year: 2007
    ..sobrinus, and (ii) analysis of the acid tolerance properties of a S. sobrinus strain lacking the glucose-specific enzyme II (EIIGIc) of the PTS. [unreadable] [unreadable] [unreadable]..
  7. Expression of Cell Surface Proteins in Streptococcus mutans
    Indranil Biswas; Fiscal Year: 2007
    ..mutans will provide opportunities for the development of new approaches to the prevention and treatment of dental caries. [unreadable] [unreadable] [unreadable]..
  8. Low pH-mediated membrane biosynthesis in S. mutans.
    Robert G Quivey; Fiscal Year: 2010
    ..mutans membranes relate to fluidity;5) finally, we will determine how S. mutans uses its fab genes to respond to membrane disrupting agents such as cerulenin and tt-farnesol. ..

Patents15

  1. DHAD VARIANTS FOR BUTANOL PRODUCTION
    Patent Number: WO2014106107-A2; Date:2014-07-03
  2. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  3. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  4. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  5. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  6. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  7. Plants with increased yield by increasing or generating one or more activities in a plant or a part thereof
    Patent Number: WO2010020654-A2; Date:2010-02-25
  8. Plants with increased yield (lt)
    Patent Number: WO2010034672-A1; Date:2010-04-01
  9. Reduced colonization of microbes at the mucosa
    Patent Number: WO2010034844-A1; Date:2010-04-01
  10. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  11. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  12. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  13. COMPUTATIONAL METHOD FOR IDETIFYING ADHESIN
    Patent Number: JP2007520718-A; Date:2007-07-26
  14. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  15. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27