Staphylococcus aureus subsp. aureus NCTC 8325

Summary

Alias: Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325

Top Publications

  1. pmc Nucleotide sequence of the gene for a fibronectin-binding protein from Staphylococcus aureus: use of this peptide sequence in the synthesis of biologically active peptides
    C Signas
    Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala
    Proc Natl Acad Sci U S A 86:699-703. 1989
  2. ncbi Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus
    L Janzon
    Department of Bacteriology, Karolinska Institutet, Stockholm, Sweden
    Mol Gen Genet 219:480-5. 1989
  3. ncbi Characterization of a Tn551-mutant of Staphylococcus aureus defective in the production of several exoproteins
    A T Giraudo
    Departamento de Microbiologia, Facultad de Ciencias Exactas, Fisico Quimicas y Naturales, Universidad Nacional Río Cuarto, Cordoba, Argentina
    Can J Microbiol 40:677-81. 1994
  4. pmc Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus
    B Wieland
    Mikrobielle Genetik, Universitat Tubingen, Federal Republic of Germany
    J Bacteriol 176:7719-26. 1994
  5. pmc Site-directed mutagenesis of the alpha-toxin gene of Staphylococcus aureus: role of histidines in toxin activity in vitro and in a murine model
    B E Menzies
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Infect Immun 62:1843-7. 1994
  6. ncbi Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus
    D McDevitt
    Microbiology Department, Moyne Institute, Trinity College, Dublin, Ireland
    Mol Microbiol 11:237-48. 1994
  7. pmc Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus
    E W Brunskill
    Program in Molecular and Cell Biology, University of Maryland, Baltimore County 21228, USA
    J Bacteriol 178:611-8. 1996
  8. ncbi Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments
    S N Coulter
    PathoGenesis Corporation, 201 Elliott Avenue West, Seattle, WA 98119, USA
    Mol Microbiol 30:393-404. 1998
  9. ncbi Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides
    A Peschel
    Mikrobielle Genetik, Universitat Tubingen, Waldhäuser Strasse 70 8, 72076 Tubingen, Germany
    J Biol Chem 274:8405-10. 1999
  10. pmc The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation
    S Rohrer
    Institute of Medical Microbiology, University of Zurich, Gloriastr 32, Postfach, CH 8028 Zurich, Switzerland
    Proc Natl Acad Sci U S A 96:9351-6. 1999

Research Grants

  1. THERAPEUTIC APPROACHES TO BIOFILM ANTIBIOTIC RESISTANCE
    Timothy Opperman; Fiscal Year: 2005
  2. c-diGMP Signal Transduction Proteins are Biofilm Drug Targets
    Timothy Opperman; Fiscal Year: 2006
  3. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
  4. Gordon Research Conference on Staphylococcal Diseases
    BRIGITTE BERGER BACHI; Fiscal Year: 2003
  5. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
  6. Nucleotide Methylation in Ribosome Maturation
    JASON RIFE; Fiscal Year: 2008
  7. CF EPITHELIAL CELLS: INTERACTIONS WITH PSEUDOMONAS
    Alice Prince; Fiscal Year: 2005
  8. Novel Therapies for BioFilm-Related Infections
    Timothy Opperman; Fiscal Year: 2005
  9. Binding and regulation mechanism for S aureus
    Ambrose Cheung; Fiscal Year: 2006
  10. Rat, a regulator of autolysis in S. aureus
    Ambrose Cheung; Fiscal Year: 2008

Patents

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
  2. Plants with increased yield
  3. Plants with increased yield
  4. Beta-lactones as antibacterial agents
  5. Plants with increased yield (lt)
  6. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
  7. Plants with increased yield (nue)
  8. HIGHLY CONSERVED GENES AND THEIR USE TO GENERATE SPECIES-SPECIFIC, GENUS-SPECIFIC, FAMILY-SPECIFIC, GROUP-SPECIFIC AND UNIVERSAL NUCLEIC ACID PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY ALGAL, ARCHAEAL, BACTERIAL, FUNGAL AND PARASITICAL MICROOR-GANISMS FROM CLINICAL SPECIMENS FOR DIAGNOSIS
  9. Beta-Lactones as antibacterial agents
  10. Targeting polypeptide

Detail Information

Publications127 found, 100 shown here

  1. pmc Nucleotide sequence of the gene for a fibronectin-binding protein from Staphylococcus aureus: use of this peptide sequence in the synthesis of biologically active peptides
    C Signas
    Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala
    Proc Natl Acad Sci U S A 86:699-703. 1989
    ..All three peptides interacted with fibronectin, as indicated by their ability to inhibit binding of fibronectin to staphylococcal cells, whereas an unrelated 37-amino acid peptide showed no inhibitory activity...
  2. ncbi Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus
    L Janzon
    Department of Bacteriology, Karolinska Institutet, Stockholm, Sweden
    Mol Gen Genet 219:480-5. 1989
    ..Determination of hld mRNA half-life in different growth phases indicated that this regulation is at the level of transcription...
  3. ncbi Characterization of a Tn551-mutant of Staphylococcus aureus defective in the production of several exoproteins
    A T Giraudo
    Departamento de Microbiologia, Facultad de Ciencias Exactas, Fisico Quimicas y Naturales, Universidad Nacional Río Cuarto, Cordoba, Argentina
    Can J Microbiol 40:677-81. 1994
    ..The phenotype of the mutant was different from that of other insertional mutants affecting exoprotein synthesis, such as agr, xpr, or sar. This new mutation has been designated sae (for S. aureus exoprotein expression)...
  4. pmc Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus
    B Wieland
    Mikrobielle Genetik, Universitat Tubingen, Federal Republic of Germany
    J Bacteriol 176:7719-26. 1994
    ..Dehydrosqualene (4,4'-diapophytoene) is successively dehydrogenated by a desaturase (CrtN) to form the yellow main intermediate 4,4'-diaponeurosporene...
  5. pmc Site-directed mutagenesis of the alpha-toxin gene of Staphylococcus aureus: role of histidines in toxin activity in vitro and in a murine model
    B E Menzies
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Infect Immun 62:1843-7. 1994
    ....
  6. ncbi Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus
    D McDevitt
    Microbiology Department, Moyne Institute, Trinity College, Dublin, Ireland
    Mol Microbiol 11:237-48. 1994
    ..Significant homology was found between the ClfA protein and the fibronectin-binding proteins of S. aureus, particularly in the N- and C-termini...
  7. pmc Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus
    E W Brunskill
    Program in Molecular and Cell Biology, University of Maryland, Baltimore County 21228, USA
    J Bacteriol 178:611-8. 1996
    ..These data suggest that the lytS and lytR gene products control the rate of autolysis in S. aureus by affecting the intrinsic murein hydrolase activity associated with the cell...
  8. ncbi Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments
    S N Coulter
    PathoGenesis Corporation, 201 Elliott Avenue West, Seattle, WA 98119, USA
    Mol Microbiol 30:393-404. 1998
    ....
  9. ncbi Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides
    A Peschel
    Mikrobielle Genetik, Universitat Tubingen, Waldhäuser Strasse 70 8, 72076 Tubingen, Germany
    J Biol Chem 274:8405-10. 1999
    ..We propose a role of the D-alanine-esterified teichoic acids which occur in many pathogenic bacteria in the protection against human and animal defense systems...
  10. pmc The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation
    S Rohrer
    Institute of Medical Microbiology, University of Zurich, Gloriastr 32, Postfach, CH 8028 Zurich, Switzerland
    Proc Natl Acad Sci U S A 96:9351-6. 1999
    ..Because of its key role FmhB is a potential target for novel antibacterial agents that could control the threat of emerging multiresistant S. aureus...
  11. pmc The intercellular adhesion (ica) locus is present in Staphylococcus aureus and is required for biofilm formation
    S E Cramton
    Mikrobielle Genetik, Universitat Tubingen, D 72076 Tubingen, Germany
    Infect Immun 67:5427-33. 1999
    ..Cross-species hybridization experiments revealed the presence of icaA in several other Staphylococcus species, suggesting that cell-cell adhesion and the potential to form biofilms is conserved within this genus...
  12. ncbi Interactive regulatory pathways control virulence determinant production and stability in response to environmental conditions in Staphylococcus aureus
    J A Lindsay
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, UK
    Mol Gen Genet 262:323-31. 1999
    ..How environmental signals are transduced to control alpha-haemolysin and serine protease production, activity and stability at multiple levels are discussed...
  13. ncbi The fibronectin-binding MSCRAMM FnbpA of Staphylococcus aureus is a bifunctional protein that also binds to fibrinogen
    E R Wann
    Center for Extracellular Matrix Biology, Department of Biochemistry and Biophysics, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030 3303, USA
    J Biol Chem 275:13863-71. 2000
    ..Finally, by overexpressing FnbpA in a mutant strain of S. aureus that lacks the expression of both ClfA and ClfB, we show that native FnbpA can mediate the interaction of S. aureus with soluble Fg...
  14. pmc Identification, cloning, and initial characterization of rot, a locus encoding a regulator of virulence factor expression in Staphylococcus aureus
    P J McNamara
    Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Bacteriol 182:3197-203. 2000
    ..We named this ORF rot (for repressor of toxins) (GenBank accession no. AF189239) because of the activity associated with rot::Tn917 mutant strains...
  15. pmc Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus
    S Jarraud
    Faculte de Medecine Laennec, 69372 Lyon Cedex 08, France
    J Bacteriol 182:6517-22. 2000
    ..This finding raises the question of the biological significance of the agr autoinduction threshold...
  16. pmc Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine
    A Peschel
    Microbial Genetics, University of Tuebingen, 72076 Tuebingen, Germany
    J Exp Med 193:1067-76. 2001
    ..MprF thus constitutes a novel virulence factor, which may be of general relevance for bacterial pathogens and represents a new target for attacking multidrug resistant bacteria...
  17. pmc PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus
    M J Horsburgh
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, England
    Infect Immun 69:3744-54. 2001
    ..However, it differs in its response to the metal balance within the cell and has the added capability of regulating iron uptake and storage...
  18. pmc SarT, a repressor of alpha-hemolysin in Staphylococcus aureus
    K A Schmidt
    Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 13755, USA
    Infect Immun 69:4749-58. 2001
    ..Collectively, these results indicated that the sarA locus, contrary to the regulatory action of agr, induced alpha-hemolysin production by repressing sarT, a repressor of hla transcription...
  19. ncbi The two-component system ArlS-ArlR is a regulator of virulence gene expression in Staphylococcus aureus
    B Fournier
    Unité de Biochimie Microbienne, URA 2172 du Centre National de la Recherche Scientifique, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 41:247-61. 2001
    ..Finally, arl was not autoregulated, but its expression was stimulated by agr and sarA. These results suggest that the Arl system interacts with both agr and sarA regulatory loci to modulate the virulence regulation network...
  20. pmc Reassessing the role of Staphylococcus aureus clumping factor and fibronectin-binding protein by expression in Lactococcus lactis
    Y A Que
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Infect Immun 69:6296-302. 2001
    ..Taken together, the present observations suggest that if antiadhesin therapy were to be developed, at least both of the clfA and fnbA products should be blocked for the therapy to be effective...
  21. pmc Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci
    P M Dunman
    Infectious Diseases, Wyeth Ayerst Research, Pearl River, New York 10965, USA
    J Bacteriol 183:7341-53. 2001
    ....
  22. ncbi Fibronectin-binding protein A of Staphylococcus aureus has multiple, substituting, binding regions that mediate adherence to fibronectin and invasion of endothelial cells
    R C Massey
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Cell Microbiol 3:839-51. 2001
    ..These findings may be of relevance to the development of preventive measures against systemic infection, and bacterial spread in the bacteraemic patient...
  23. pmc Strain-dependent differences in the regulatory roles of sarA and agr in Staphylococcus aureus
    Jon S Blevins
    Department of Microbiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Infect Immun 70:470-80. 2002
    ..Taken together, these results suggest that studies defining the regulatory roles of sarA and agr by using RN6390 are not always representative of the events that occur in clinical isolates of S. aureus...
  24. ncbi MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake
    Malcolm J Horsburgh
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Mol Microbiol 44:1269-86. 2002
    ..The co-ordinated regulation of metal ion homeostasis and oxidative stress resistance via the regulators MntR, PerR and Fur of S. aureus is discussed...
  25. ncbi Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization
    Louise M O'Brien
    Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College Dublin, Dublin 2, Ireland
    Cell Microbiol 4:759-70. 2002
    ..We also showed that ClfB is transcribed by S. aureus in the human nares. We propose that ClfB is a major determinant in S. aureus nasal colonization...
  26. pmc Global regulation of Staphylococcus aureus genes by Rot
    B Said-Salim
    Public Health Research Institute at the International Center of Public Health, Newark, New Jersey 07103, USA
    J Bacteriol 185:610-9. 2003
    ..aureus genes. Our data also indicate that Rot and agr have opposing effects on select target genes. These results provide further insight into the role of Rot in the regulatory cascade of S. aureus virulence gene expression...
  27. pmc Transcriptional induction of the penicillin-binding protein 2 gene in Staphylococcus aureus by cell wall-active antibiotics oxacillin and vancomycin
    Susan Boyle-Vavra
    Department of Pediatrics, The University of Chicago, Illinois 60637, USA
    Antimicrob Agents Chemother 47:1028-36. 2003
    ..These data support the idea that pbpB expression is modulated by a trans-acting factor in response to the presence of the cell wall-active antibiotics vancomycin and oxacillin...
  28. ncbi Characterization of novel LPXTG-containing proteins of Staphylococcus aureus identified from genome sequences
    Fiona M Roche
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Microbiology 149:643-54. 2003
    ..Several IgG samples purified from patients recovering from S. aureus infections had higher titres against Sas proteins than control IgG, suggesting that expression occurred during infection in some patients...
  29. pmc Identification of genes controlled by the essential YycG/YycF two-component system of Staphylococcus aureus
    Sarah Dubrac
    Unité de Biochimie Microbienne, CNRS URA 2172, Institut Pasteur, 75724 Paris Cedex 15, France
    J Bacteriol 186:1175-81. 2004
    ....
  30. ncbi MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance
    Petra Staubitz
    Cellular and Molecular Microbiology, Medical Microbiology Department, University of Tubingen, Elfriede Aulhorn Str 6, D 72076 Tubingen, Germany
    FEMS Microbiol Lett 231:67-71. 2004
    ..This study forms the basis for further detailed analyses of L-PG biosynthesis and its role in bacterial infections...
  31. ncbi IsdA of Staphylococcus aureus is a broad spectrum, iron-regulated adhesin
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK
    Mol Microbiol 51:1509-19. 2004
    ..Thus for S. aureus, iron is an important marker for the host environment, to which the bacterium responds by differential regulation of at least one element of its adhesive strategy...
  32. ncbi The N-terminal A domain of fibronectin-binding proteins A and B promotes adhesion of Staphylococcus aureus to elastin
    Fiona M Roche
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Biol Chem 279:38433-40. 2004
    ..This interaction was inhibited by soluble elastin peptides, suggesting a specific receptor-ligand interaction...
  33. ncbi Clumping factor B, a fibrinogen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) adhesin of Staphylococcus aureus, also binds to the tail region of type I cytokeratin 10
    Evelyn J Walsh
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 279:50691-9. 2004
    ..We provide an explanation for the molecular basis for S. aureus adherence to the squamous epithelium and suggest that nasal colonization might be prevented by reagents that inhibit this interaction...
  34. ncbi Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus
    Agnieszka Bera
    Microbial Genetics, University of Tubingen, D 72076 Tubingen, Auf der Morgenstelle, Germany
    Mol Microbiol 55:778-87. 2005
    ..We identified the first bacterial peptidoglycan-specific O-acetyltransferase in S. aureus and showed that OatA, an integral membrane protein, is the molecular basis for the high lysozyme resistance in staphylococci...
  35. ncbi Identification of an essential glycoprotease in Staphylococcus aureus
    Li Zheng
    Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Avenue, St Paul, MN 55108, USA
    FEMS Microbiol Lett 245:279-85. 2005
    ..Our results indicate that Gcp is a potential novel target for the development of antimicrobials against S. aureus infection...
  36. pmc The multifunctional Staphylococcus aureus autolysin aaa mediates adherence to immobilized fibrinogen and fibronectin
    Christine Heilmann
    Institute of Medical Microbiology, University of Munster, Domagkstr 10, D 48149 Munster, Germany
    Infect Immun 73:4793-802. 2005
    ..Finally, an aaa knockout mutant showed reduced adherence to surface-adsorbed fibrinogen and fibronectin, strongly suggesting a role for Aaa in the colonization of host factor-coated polymer surfaces and/or host tissue...
  37. ncbi Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases
    Suzan H M Rooijakkers
    Eijkman Winkler Institute, University Medical Center Utrecht, G04 614, 3584 CX Utrecht, The Netherlands
    Nat Immunol 6:920-7. 2005
    ..As a highly active and small soluble protein that acts exclusively on surfaces, staphylococcal complement inhibitor may represent a promising anti-inflammatory molecule...
  38. pmc Functional analysis of luxS in Staphylococcus aureus reveals a role in metabolism but not quorum sensing
    Neil Doherty
    Institute of Infections, Immunity, and Inflammation, University of Nottingham, Centre for Biomolecular Sciences, Nottingham NG7 2RD, United Kingdom
    J Bacteriol 188:2885-97. 2006
    ..aureus RN6390B during intracellular growth in epithelial cells: the wild type and a luxS mutant showed very similar growth patterns after their internalization by MAC-T cells...
  39. ncbi Early expression of SCIN and CHIPS drives instant immune evasion by Staphylococcus aureus
    Suzan H M Rooijakkers
    Eijkman Winkler Center, University Medical Center Utrecht, Utrecht, The Netherlands
    Cell Microbiol 8:1282-93. 2006
    ..aureus proteins early during growth. Because SCIN and CHIPS are both efficient modulators of neutrophil chemotaxis, phagocytosis and killing, their early expression is necessary for efficient modulation of the early immune response...
  40. pmc Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair
    Antje Michel
    Institut für Molekulare Infektionsbiologie, Rontgenring 11, D 97070 Wurzburg, Germany
    J Bacteriol 188:5783-96. 2006
    ..Our results indicate a strong impact of ClpP proteolytic activity on virulence, stress response, and physiology in S. aureus...
  41. pmc Catalase (KatA) and alkyl hydroperoxide reductase (AhpC) have compensatory roles in peroxide stress resistance and are required for survival, persistence, and nasal colonization in Staphylococcus aureus
    Kate Cosgrove
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom
    J Bacteriol 189:1025-35. 2007
    ..Thus, oxidative-stress resistance is an important factor in the ability of S. aureus to persist in the hospital environment and so contribute to the spread of human disease...
  42. pmc Interaction of the GraRS two-component system with the VraFG ABC transporter to support vancomycin-intermediate resistance in Staphylococcus aureus
    Michael Meehl
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA
    Antimicrob Agents Chemother 51:2679-89. 2007
    ..aureus phenotype and may hold clues to the selective pressures on staphylococci upon exposure to selective cationic peptide antibiotics used in clinical practice...
  43. ncbi Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins
    Heather M Baker
    Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand
    J Mol Biol 374:1298-308. 2007
    ..Structural comparisons also showed that the Sia binding site in SSL5 contains a substructure that is shared by other Sia binding proteins from bacteria as well as viruses and represents a common binding motif...
  44. pmc Characterization of the accessory Sec system of Staphylococcus aureus
    Ian R Siboo
    Division of Infectious Diseases, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    J Bacteriol 190:6188-96. 2008
    ..Thus, the accessory Sec system of S. aureus is required for the export of SraP, and it appears to be dedicated to the transport of this substrate exclusively...
  45. pmc Transcriptome and functional analysis of the eukaryotic-type serine/threonine kinase PknB in Staphylococcus aureus
    Stefanie Donat
    Universitat Wurzburg, Institut für Molekulare Infektionsbiologie, Wurzburg, Germany
    J Bacteriol 191:4056-69. 2009
    ..The results of this study strongly indicate that PknB has a role in regulation of purine biosynthesis, autolysis, and central metabolic processes in S. aureus...
  46. pmc Synthetic effects of secG and secY2 mutations on exoproteome biogenesis in Staphylococcus aureus
    Mark J J B Sibbald
    Department of Medical Microbiology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    J Bacteriol 192:3788-800. 2010
    ..Additionally, the results suggest that SecY2 can interact with the Sec1 channel, which would be consistent with the presence of a single set of secE and secG genes in S. aureus...
  47. doi Absence of nucleoid occlusion effector Noc impairs formation of orthogonal FtsZ rings during Staphylococcus aureus cell division
    Helena Veiga
    Laboratory of Bacterial Cell Biology, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Avenida da República, Apartado 127, 2781 901 Oeiras, Portugal
    Mol Microbiol 80:1366-80. 2011
    ..This is achieved via the action of Noc which restricts the placement of the division septum to one of an infinite number of potential division planes that exist in S. aureus...
  48. pmc Characterization of components of the Staphylococcus aureus mRNA degradosome holoenzyme-like complex
    Christelle M Roux
    Department of Microbiology and Immunology, University of Rochester Medical Center, School of Medicine and Dentistry, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Bacteriol 193:5520-6. 2011
    ..Results also revealed that the recently recognized RNase RnpA interacts with the S. aureus degradosome and that this interaction is conserved in other Gram-positive organisms...
  49. pmc New range of vectors with a stringent 5-fluoroorotic acid-based counterselection system for generating mutants by allelic replacement in Staphylococcus aureus
    Peter Redder
    Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland
    Appl Environ Microbiol 78:3846-54. 2012
    ..Finally, as proof of concept, we present six deletions or modifications of components in the S. aureus degradosome as well as the operon containing the cshB DEAD box helicase...
  50. pmc The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus
    Stella Oun
    Department of Microbiology and Molecular Medicine, CMU, Medical Faculty, University of Geneva, Geneve, Switzerland
    RNA Biol 10:157-65. 2013
    ....
  51. pmc Identification of a novel gene cluster encoding staphylococcal exotoxin-like proteins: characterization of the prototypic gene and its protein product, SET1
    R J Williams
    Cellular Microbiology Research Group, Division of Surgical Sciences, University College London, London, United Kingdom
    Infect Immun 68:4407-15. 2000
    ..The distribution of allelic variants of the set genes among strains of S. aureus may contribute to differences in the pathogenic potential of this bacterium...
  52. ncbi Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease
    F M McAleese
    Microbiology Department, Moyne Institute for Preventive Medicine, Trinity College, Dublin 2, Ireland
    J Biol Chem 276:29969-78. 2001
    ..Cleavage was detected at two sites, one located between residues Ser(197) and Leu(198) and the other between Ala(199) and Val(200). The truncated form of ClfB did not bind fibrinogen...
  53. ncbi Dispersed mode of Staphylococcus aureus cell wall synthesis in the absence of the division machinery
    Mariana G Pinho
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Mol Microbiol 50:871-81. 2003
    ..The results have implications for understanding the nature of S. aureus morphogenesis and for inhibitors of cell division proteins as drug targets...
  54. pmc Cytoplasmic control of premature activation of a secreted protease zymogen: deletion of staphostatin B (SspC) in Staphylococcus aureus 8325-4 yields a profound pleiotropic phenotype
    Lindsey N Shaw
    Department of Biochemistry and Molecular Biology, University of Georgia, Life Sciences Bldg, Athens, GA 30602, USA
    J Bacteriol 187:1751-62. 2005
    ..Seemingly, some of these proteins may play a role in protein secretion; hence, their proteolytic inactivation by SspB has pleiotropic effects on the SspC-deficient mutant...
  55. pmc Investigations into sigmaB-modulated regulatory pathways governing extracellular virulence determinant production in Staphylococcus aureus
    Lindsey N Shaw
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    J Bacteriol 188:6070-80. 2006
    ..Thus, we propose that the loss of individual genes in this chromosomal hot spot region results in a destabilization of cellular harmony and disruption of the sigmaB regulatory cascade...
  56. pmc Transcriptional profiling of target of RNAIII-activating protein, a master regulator of staphylococcal virulence
    Moshe Korem
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Israel
    Infect Immun 73:6220-8. 2005
    ..TRAP is thus demonstrated to be a master regulator of staphylococcal pathogenesis...
  57. pmc Molecular basis of resistance to muramidase and cationic antimicrobial peptide activity of lysozyme in staphylococci
    Silvia Herbert
    Microbial Genetics Department, University of Tubingen, Tubingen, Germany
    PLoS Pathog 3:e102. 2007
    ..The two lysozyme activities act synergistically, as the oatA/dltA or oatA/graRS double mutants are much more susceptible to lysozyme than each of the single mutants...
  58. pmc Sequence, expression in Escherichia coli, and analysis of the gene encoding a novel intracellular protease (PfpI) from the hyperthermophilic archaeon Pyrococcus furiosus
    S B Halio
    Department of Chemical Engineering, North Carolina State University, Raleigh, 27695 7905, USA
    J Bacteriol 178:2605-12. 1996
    ..identified only two similar amino acid sequences: an open reading frame of unknown function from Staphylococcus aureus NCTC 8325 (171 amino acid residues, 18...
  59. pmc Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome
    E Y Ng
    Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114 2696
    Antimicrob Agents Chemother 38:1345-55. 1994
    ..locus, flqB, linked to transposon insertion omega 1108 and fus on the SmaI D fragment of the Staphylococcus aureus NCTC 8325 chromosome, the same fragment that contains the norA gene. S...
  60. ncbi The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil)
    S D Cox
    Centre for Biostructural and Biomolecular Research, University of Western Sydney, Hawkesbury, New South Wales, Western Australia
    J Appl Microbiol 88:170-5. 2000
    ..of action against the Gram-negative bacterium Escherichia coli AG100, the Gram-positive bacterium Staphylococcus aureus NCTC 8325, and the yeast Candida albicans has been investigated using a range of methods...
  61. doi The inability of a bacteriophage to infect Staphylococcus aureus does not prevent it from specifically delivering a photosensitizer to the bacterium enabling its lethal photosensitization
    C K Hope
    Division of Microbial Diseases, UCL Eastman Dental Institute, London, UK
    J Antimicrob Chemother 64:59-61. 2009
    ..In this study we have investigated whether a bacteriophage requires the capacity to infect the bacterium to enhance lethal photosensitization when linked to a photosensitizer...
  62. doi Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR
    TIMOTHY J OPPERMAN
    Microbiotix, Inc, Worcester, MA 01605 4332, United States
    Bioorg Med Chem 18:2123-30. 2010
    ..To study the mechanism of action of bis-indoles, selections for mutants of Staphylococcus aureus NCTC 8325 with reduced susceptibility to several chemically related bis-indoles were carried out using serial ..
  63. ncbi Staphylococcal peptidoglycan interpeptide bridge biosynthesis: a novel antistaphylococcal target?
    U Kopp
    Bayer AG, Pharma Research Antiinfectives I, Wuppertal, Germany
    Microb Drug Resist 2:29-41. 1996
    ..The drastic loss of beta-lactam resistance after inactivation of FemA or partial impairment of FemX even beyond the level of the sensitive wild-type strains renders these proteins attractive antistaphylococcal targets...
  64. ncbi Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides
    J Luba
    Department of Biochemistry, Wake Forest University Medical Center, Winston Salem, North Carolina 27157, USA
    Biochemistry 38:2725-37. 1999
    ..The EH2.NADPH/EH4.NADP+ complex which results is reoxidized quantitatively in titrations with CoASSCoA, supporting a possible role for the asymmetric reduced dimer in catalysis...
  65. ncbi SarA and not sigmaB is essential for biofilm development by Staphylococcus aureus
    Jaione Valle
    Instituto de Agrobiotecnología y Recursos Naturales and Dpto de Producción Agraria, Universidad Pública de Navarra CSIC, Pamplona 31006, Spain
    Mol Microbiol 48:1075-87. 2003
    ....
  66. pmc Transcriptional activation of the Staphylococcus aureus putP gene by low-proline-high osmotic conditions and during infection of murine and human tissues
    William R Schwan
    Department of Microbiology, University of Wisconsin La Crosse, 1725 State Street, La Crosse, WI 54601, USA
    Infect Immun 74:399-409. 2006
    ..Thus, putP is transcriptionally activated by a low-proline and high osmotic environment both in growth media and in murine or human clinical specimens...
  67. pmc Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315
    T Ito
    Department of Bacteriology, Juntendo University, Tokyo, Japan
    Antimicrob Agents Chemother 43:1449-58. 1999
    ..However, there was no ORF that might encode mec DNA-specific transposase or integrase proteins, indicating that the mec DNA is not a transposon or a bacteriophage in nature...
  68. ncbi Functional expression of the alpha-hemolysin of Staphylococcus aureus in intact Escherichia coli and in cell lysates. Deletion of five C-terminal amino acids selectively impairs hemolytic activity
    B Walker
    Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545
    J Biol Chem 267:10902-9. 1992
    ..The mutant polypeptide nevertheless binds tightly to erythrocytes as a monomer, strengthening the idea that oligomerization is required for cell lysis...
  69. ncbi The coagulase of Staphylococcus aureus 8325-4. Sequence analysis and virulence of site-specific coagulase-deficient mutants
    P Phonimdaeng
    Department of Microbiology, Moyne Institute, Trinity College, Dublin, Ireland
    Mol Microbiol 4:393-404. 1990
    ..This contradicts findings of several groups using Coa- mutants generated by chemical mutagenesis and suggests that the earlier results were obtained with strains that had suffered additional mutations in virulence-related genes...
  70. ncbi Nucleotide sequence analysis of the gene for protein A from Staphylococcus aureus Cowan 1 (NCTC8530) and its enhanced expression in Escherichia coli
    H L Shuttleworth
    Microbial Technology Laboratory, PHLS, Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wilts, U K
    Gene 58:283-95. 1987
    ..The homology to the latter probably identifies the Fc-binding region in the immunoglobulin-binding domains of SPA. Enhanced production of SPA in Escherichia coli was achieved using the lac promoter immediately upstream from the spa gene...
  71. ncbi A genetic system for analysis of staphylococcal nuclease
    D Shortle
    Gene 22:181-9. 1983
    ..In combination with present methods for efficient in vitro mutagenesis, this plasmid-based genetic system can be applied to the detailed genetic analysis of this small, biochemically and biophysically well-characterized enzyme...
  72. pmc Primary sequence of the alpha-toxin gene from Staphylococcus aureus wood 46
    G S Gray
    Infect Immun 46:615-8. 1984
    ..The mature alpha-toxin protein had a molecular size of 33,000 and contained only three short regions of high hydrophobicity in addition to a number of short, weakly hydrophobic regions...
  73. pmc Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus
    L Ferrero
    Departement des Biotechnologies, Rhone Poulenc Rorer S A, Vitry sur Seine, France
    Antimicrob Agents Chemother 39:1554-8. 1995
    ..Ferrero, B. Cameron, B. Manse, D. Lagneaux, J. Crouzet, A. Famechon, and F. Blanche, Mol. Microbiol. 13:641-653, 1994) that DNA topoisomerase IV is a primary target of fluoroquinolones in S. aureus...
  74. ncbi A homologue to the Escherichia coli alkyl hydroperoxide reductase AhpC is induced by osmotic upshock in Staphylococcus aureus
    L Armstrong-Buisseret
    Department of Applied Biochemistry and Food Science, University of Nottingham, Faculty of Agricultural and Food Sciences, Leicestershire, UK
    Microbiology 141:1655-61. 1995
    ..Exposure of S. aureus to varying concentrations of H202 did not result in the detectable induction of AhpC...
  75. ncbi Identification of the active-site nucleophile in 6-phospho-beta-galactosidase from Staphylococcus aureus by labelling with synthetic inhibitors
    P Staedtler
    Arbeitsgruppe Physiologie der Mikroorganismen, Abteilung Biologie, Ruhr Universitat Bochum, Germany
    Eur J Biochem 232:658-63. 1995
    ..It was shown to be identical to an authentic, synthetic sample. From this, it is evident that E375 is the active-site nucleophile of 6-phospho-galactosidase, consistent with previous findings for enzymes in this family...
  76. ncbi Comparative biochemical and molecular analysis of the Staphylococcus hyicus, Staphylococcus aureus and a hybrid lipase. Indication for a C-terminal phospholipase domain
    K Nikoleit
    Universitat Tubingen, Germany
    Eur J Biochem 228:732-8. 1995
    ..hyicus lipase. The fact that two closely related enzymes differ in the need for Ca2+ underscores the notion that it plays a structural rather than a catalytic role...
  77. pmc A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-L-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterization
    T Oshida
    Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 92:285-9. 1995
    ..aureus...
  78. ncbi Identification of a chromosomally encoded ABC-transport system with which the staphylococcal erythromycin exporter MsrA may interact
    J I Ross
    Department of Microbiology, University of Leeds, UK
    Gene 153:93-8. 1995
    ..There was no further sequence similarity outside these conserved regions. These results indicate that the chromosomes of S. hominis and S. aureus contain sequences encoding a potential TM protein with which MsrA might interact...
  79. pmc Localized perforation of the cell wall by a major autolysin: atl gene products and the onset of penicillin-induced lysis of Staphylococcus aureus
    M Sugai
    Department of Microbiology, Hiroshima University School of Dentistry, Japan
    J Bacteriol 179:2958-62. 1997
    ....
  80. ncbi Characterization of a novel structural member, LukE-LukD, of the bi-component staphylococcal leucotoxins family
    A Gravet
    UPRES EA 1318, Institut de Bacteriologie de la Faculte de Medecine, Université Louis Pasteur Hôpitaux Universitaires de Strasbourg, France
    FEBS Lett 436:202-8. 1998
    ..005). LukE+LukD was as effective as the Panton-Valentine leucocidin for inducing dermonecrosis when injected in the rabbit skin, but not hemolytic and poorly leucotoxic compared to other leucotoxins expressed by Staphylococcus aureus...
  81. ncbi Clumping factor B (ClfB), a new surface-located fibrinogen-binding adhesin of Staphylococcus aureus
    D Ni Eidhin
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 30:245-57. 1998
    ....
  82. ncbi Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureus
    N Noguchi
    Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
    FEMS Microbiol Lett 172:247-53. 1999
    ..Our results indicated that four or more antiseptic-resistance genes exist in methicillin-resistant S. aureus and that antiseptic-resistant methicillin-resistant S. aureus strains without qacA and smr are widely spread in Japan...
  83. pmc Antibacterial action of extracellular mammalian group IIA phospholipase A2 against grossly clumped Staphylococcus aureus
    M E Dominiecki
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Infect Immun 67:2299-305. 1999
    ..Thus, the extracellular mobilization of group IIA PLA2 during inflammation may provide a mechanism by which the host can control the proliferation and survival of S. aureus even after bacterial clumping...
  84. ncbi Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis
    A Bouhss
    Biochimie Structurale et Cellulaire, CNRS, Batiment 430, Universite Paris Sud, F 91405, Orsay, France
    Mol Microbiol 34:576-85. 1999
    ..It was noteworthy that S. aureus MraY was functional in E. coli. An increased MraY transferase activity was observed only with the untruncated hybrids from both organisms...
  85. pmc An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190
    K Kaneda
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 98:932-7. 2001
    ..aureus and of the different enzymatic properties of mammalian (type 1) and S. aureus (type 2) isomerases, this unusual enzyme is considered to be a suitable molecular target for the screening of antibacterial drugs specific to S. aureus...
  86. pmc Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus
    M Bischoff
    Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
    J Bacteriol 183:5171-9. 2001
    ..The data presented here suggest that sigma(B) increases sar expression while simultaneously reducing the RNAIII level in a growth phase-dependent manner...
  87. ncbi Molecular characterization of a chromosomal locus in Staphylococcus aureus that contributes to oxidative defence and is highly induced by the cell-wall-active antibiotic oxacillin
    V K Singh
    Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, IL 61790, USA
    Microbiology 147:3037-45. 2001
    ..An insertional knockout mutation in the first gene of this operon resulted in increased susceptibility of the mutant to H2O2 compared to the parent strain, but not to oxacillin...
  88. pmc A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A
    Champion C S Deivanayagam
    Center for Biophysical Sciences and Engineering, School of Optometry, 244 CBSE, 1025 18th Street South, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    EMBO J 21:6660-72. 2002
    ....
  89. pmc MprF-mediated lysinylation of phospholipids in Staphylococcus aureus leads to protection against oxygen-independent neutrophil killing
    Sascha A Kristian
    Microbial Genetics, University of Tubingen, 72076 Tubingen, Germany
    Infect Immun 71:546-9. 2003
    ..These results demonstrate the impact and specificity of MprF-mediated CAMP resistance and underscore the role of defensin-like peptides in innate host defense...
  90. ncbi Studies on the expression of regulatory locus sae in Staphylococcus aureus
    Ana T Giraudo
    Departamento de Microbiologia e Inmunologia, Facultad de Ciencias Exactas Físico, Química y Naturales, Universidad Nacional de Rio Cuarto, Rio Cuarto, Cordoba, Argentina
    Curr Microbiol 46:246-50. 2003
    ..This work, as well as previous studies, reveals a complex hierarchical regulatory network involving several loci that control the expression of virulence determinants in S. aureus...
  91. pmc Crystal structure of the SarS protein from Staphylococcus aureus
    Ronggui Li
    Integrated Department of Immunology, National Jewish Medical and Research Center, and Department of Pharmacology, Biomolecular Structure Program, School of Medicine, University of Colorado Health Science Center, Denver, Colorado 80206, USA
    J Bacteriol 185:4219-25. 2003
    ..Based on the structural differences of SarR, SarS, and MarR, we further classified these winged-helix proteins to three subfamilies, SarA, SarS, and MarR. Finally, a possible transcription regulation mechanism is proposed...
  92. pmc MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuation
    Jutta Rossi
    Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
    Antimicrob Agents Chemother 47:2558-64. 2003
    ..These observations suggest that MsrR is a new component involved in sarA attenuation and the regulatory network controlling virulence gene expression in S. aureus...
  93. ncbi Latent LytM at 1.3A resolution
    Sergey G Odintsov
    International Institute of Molecular and Cell Biology, ul Trojdena 4, 02 109 Warsaw, Poland
    J Mol Biol 335:775-85. 2004
    ..aureus supernatant. The "asparagine switch" in LytM is analogous to the "cysteine switch" in pro-matrix metalloproteases...
  94. ncbi Expression of staphylococcal clumping factor A impedes macrophage phagocytosis
    Niklas Palmqvist
    Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10 A, S 413 46 Goteborg, Sweden
    Microbes Infect 6:188-95. 2004
    ..Both the protection against phagocytosis and the enhanced immunostimulatory activity provided by ClfA expression are likely to contribute to the in vivo virulence of S. aureus...
  95. pmc Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde
    Luan Tao
    Biological and Chemical Sciences and Engineering, Central Research and Development, E I DuPont de Nemours Inc, E328 B48, Wilmington, Deleware 19880 0328, USA
    Appl Environ Microbiol 71:3294-301. 2005
    ..coli as the predominant carotenoid. This C30 dialdehyde is a dark-reddish purple pigment that may have potential uses in foods and cosmetics...
  96. pmc SarA positively controls bap-dependent biofilm formation in Staphylococcus aureus
    Maria Pilar Trotonda
    Instituto Valenciano de Investigaciones Agrarias, Carretera Náquera Moncada Km 4, 5, 46113 Moncada, Valencia, Spain
    J Bacteriol 187:5790-8. 2005
    ..Based on the previous studies of others as well as our work demonstrating the role for SarA in icaADBC and bap expression, we propose that SarA is an essential regulator controlling biofilm formation in S. aureus...
  97. pmc MepR, a repressor of the Staphylococcus aureus MATE family multidrug efflux pump MepA, is a substrate-responsive regulatory protein
    Glenn W Kaatz
    The John D Dingell Department of Veterans Affairs Medical Center, and Department of Medicine, Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Antimicrob Agents Chemother 50:1276-81. 2006
    ....
  98. ncbi Regulation of Staphylococcus aureus alpha-toxin gene (hla) expression by agr, sarA, and sae in vitro and in experimental infective endocarditis
    Yan Q Xiong
    Department of Medicine, Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, CA, USA
    J Infect Dis 194:1267-75. 2006
    ..However, their relative in vivo contributions to hla expression, particularly in endovascular infections, have not been defined...
  99. ncbi Haem recognition by a Staphylococcus aureus NEAT domain
    Jason C Grigg
    Department of Microbiology and Immunology, Life Sciences Institute, The University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Mol Microbiol 63:139-49. 2007
    ..An analysis of IsdA structure-sequence alignments indicate that conservation of Tyr(166) is a predictor of haem binding by NEAT domains...
  100. ncbi Fibrinogen and elastin bind to the same region within the A domain of fibronectin binding protein A, an MSCRAMM of Staphylococcus aureus
    Fiona M Keane
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 63:711-23. 2007
    ....
  101. pmc Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans
    Heiman F L Wertheim
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Med 5:e17. 2008
    ..aureus colonizes the nose are still unknown. The staphylococcal cell-wall protein clumping factor B (ClfB) promotes adhesion to squamous epithelial cells in vitro and might be a physiologically relevant colonization factor...

Research Grants16

  1. THERAPEUTIC APPROACHES TO BIOFILM ANTIBIOTIC RESISTANCE
    Timothy Opperman; Fiscal Year: 2005
    ..We will develop these compounds into innovative drugs that will be used in combination with clinically relevant antibiotics to eradicate biofilm infections. ..
  2. c-diGMP Signal Transduction Proteins are Biofilm Drug Targets
    Timothy Opperman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  3. Proline uptake in staphylococcus aureus pathogenesis
    WILLIAM SCHWAN; Fiscal Year: 2002
    ..The results of this study will help us understand the role of proline transport in S. aureus infections. ..
  4. Gordon Research Conference on Staphylococcal Diseases
    BRIGITTE BERGER BACHI; Fiscal Year: 2003
    ..S. This will afford a unique and rich opportunity for fellowship and scientific exchange between young and established investigators in the field. ..
  5. OmpR and acid regulation of Escherichia coli fim genes
    WILLIAM SCHWAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  6. Nucleotide Methylation in Ribosome Maturation
    JASON RIFE; Fiscal Year: 2008
    ..Ultimately, these studies will reveal molecular details of methyltransferase reactions as well as likely provide the first evidence for a universal step in ribosome biogenesis. ..
  7. CF EPITHELIAL CELLS: INTERACTIONS WITH PSEUDOMONAS
    Alice Prince; Fiscal Year: 2005
    ..Using genetically defined mutants, the contribution of PLC to epithelial damage in normal and CF cells will be examined. ..
  8. Novel Therapies for BioFilm-Related Infections
    Timothy Opperman; Fiscal Year: 2005
    ..epidermidis. The work in Phase I will provide all the molecular genetic tools and screening methods needed in Phase II for the discovery of potent small molecule inhibitors of staphylococcal biofilm formation. ..
  9. Binding and regulation mechanism for S aureus
    Ambrose Cheung; Fiscal Year: 2006
    ..An understanding of these mechanisms will facilitate the development of novel agents that interfere with the function of the SarA family and the ensuing synthesis of cell wall adhesins and toxins. ..
  10. Rat, a regulator of autolysis in S. aureus
    Ambrose Cheung; Fiscal Year: 2008
    ..Our long-term goal is to promote autolysis with an anti-Rat or pro-SarV strategy without developing an untoward impact on virulence. ..
  11. IN VIVO GENE EXPRESSION IN STAPHYLOCCUS AUREUS
    Ambrose Cheung; Fiscal Year: 2009
    ..Upon the completion of these studies, we hope to understand how sae is activated in vivo and what target genes sae impacts during infection. ..
  12. Characterization of sar-agr Interactions in S. aureus
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2010
    ..Our goal is to understand how SarA controls target gene and how other intracellular regulators affect SarA expression in S. aureus. ..
  13. The toxin-antitoxin system of Staphylococcus aureus.
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2010
    ..As therapy options against multidrug resistant S. aureus are limited, our screening assays will provide the initial compounds against MazE for the development of novel antimicrobial therapy against S. aureus ..
  14. BACTERIAL INDUCTION OF CYTOKINE EXPRESSION IN THE LUNG
    Alice Prince; Fiscal Year: 2005
    ....

Patents12

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  2. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  3. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  4. Beta-lactones as antibacterial agents
    Patent Number: WO2009106211-A1; Date:2009-09-03
  5. Plants with increased yield (lt)
    Patent Number: WO2010034672-A1; Date:2010-04-01
  6. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  7. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  8. HIGHLY CONSERVED GENES AND THEIR USE TO GENERATE SPECIES-SPECIFIC, GENUS-SPECIFIC, FAMILY-SPECIFIC, GROUP-SPECIFIC AND UNIVERSAL NUCLEIC ACID PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY ALGAL, ARCHAEAL, BACTERIAL, FUNGAL AND PARASITICAL MICROOR-GANISMS FROM CLINICAL SPECIMENS FOR DIAGNOSIS
    Patent Number: JP2003511015-A; Date:2003-03-25
  9. Beta-Lactones as antibacterial agents
    Patent Number: JP2011517315-A; Date:2011-06-02
  10. Targeting polypeptide
    Patent Number: WO2005092918-A2; Date:2005-10-06
  11. FUNCTIONALIZATION OF CAROTENOID COMPOUNDS
    Patent Number: JP2005521390-A; Date:2005-07-21
  12. Highly conserved genes and their use to generate probes and primers for detection of microorganisms
    Patent Number: WO0123604-A2; Date:2001-04-05