Genomes and Genes
Staphylococcus aureus subsp. aureus MW2
Alias: Staphylococcus aureus (strain MW2), Staphylococcus aureus subsp. aureus str. MW2
- Detection of seg, seh, and sei genes in Staphylococcus aureus isolates and determination of the enterotoxin productivities of S. aureus isolates Harboring seg, seh, or sei genesKatsuhiko Omoe
Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University, Ueda 3 18 8, Morioka, Iwate, Japan
J Clin Microbiol 40:857-62. 2002..aureus strains harboring seg and sei genes. These results suggest the importance of quantitative assessment of SEG and SEI production in foods in order to clarify the relationship between these new SEs and food poisoning...
- Mechanism of reduced vancomycin susceptibility conferred by walK mutation in community-acquired methicillin-resistant Staphylococcus aureus strain MW2Jinfeng Hu
Department of Microbiology and Immunology and CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, China
Antimicrob Agents Chemother 59:1352-5. 2015..An electrophoretic mobility shift assay indicated that WalK (G223D)-phosphorylated WalR had a reduced capacity to bind to the atlA promoter. ..
- High precision multi-genome scale reannotation of enzyme function by EFICAzAdrian K Arakaki
Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30318, USA
BMC Genomics 7:315. 2006..We have performed a reannotation of 245 genomes using an updated version of EFICAz, a highly precise method for enzyme function prediction...
- De novo bacterial genome sequencing: millions of very short reads assembled on a desktop computerDavid Hernandez
Genomic Research Laboratory, Infectious Diseases Service, Geneva University Hospitals and the University of Geneva, CH 1211 Geneva 4, Switzerland
Genome Res 18:802-9. 2008..5- to 3.0-kb fragments. We also provide indications that the broad coverage achieved by high-throughput sequencing might allow for the detection of clonal polymorphisms in the set of DNA molecules being sequenced...
- NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscessesYanpeng Ding
Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114 2696, USA
J Bacteriol 190:7123-9. 2008....
- Simulated antibiotic exposures in an in vitro hollow-fiber infection model influence toxin gene expression and production in community-associated methicillin-resistant Staphylococcus aureus strain MW2Solen Pichereau
Pharmacy Practice Division, School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA
Antimicrob Agents Chemother 56:140-7. 2012..SXT had minimal effects on toxin gene regulation, but it increased production and cytotoxicity of PVL toxin in the model and may enhance virulence when it is used to treat severe infections...
- Synthetic teichoic acid conjugate vaccine against nosocomial Gram-positive bacteriaDiana Laverde
Division of Infectious Diseases, Department of Medicine, University Medical Center Freiburg, Freiburg, Germany EA4655 U2RM Stress Virulence, University of Caen Lower Normandy, Caen, France
PLoS ONE 9:e110953. 2014..faecalis and other Gram-positive bacteria. ..
- Role of two-component systems in the resistance of Staphylococcus aureus to antibacterial agentsMiki Kawada-Matsuo
Department of Oral Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Virulence 2:427-30. 2011..Therefore, S. aureus possesses at least three TCSs that are involved in mediating its resistance to antibacterial agents...
- Role of ArlRS in autolysis in methicillin-sensitive and methicillin-resistant Staphylococcus aureus strainsGuido Memmi
Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire, USA
J Bacteriol 194:759-67. 2012..Also, the autolytic phenotype in the arlRS mutant of MSSA strain Newman could be rescued by a mutation in either atl or lytM. Together, these data showed that ArlRS impacts autolysis differently in MSSA and MRSA strains...
- Elevated enterotoxin A expression and formation in Staphylococcus aureus and its association with prophage inductionRong Cao
Applied Microbiology, Department of Chemistry, Faculty of Engineering, Lund University, Lund, Sweden
Appl Environ Microbiol 78:4942-8. 2012..The high-SEA-producing group, in particular the prophage-inducible sea(1) group, may be more relevant to staphylococcal food poisoning than the low-SEA-producing group, harboring mainly sea(2)...
- Molecular characterization and expression of a gene encoding a Staphylococcus aureus collagen adhesinJ M Patti
Department of Biochemistry, University of Alabama, Birmingham 35294 0005
J Biol Chem 267:4766-72. 1992..Finally, the bacterial lysate containing the recombinant adhesin can effectively inhibit the binding of soluble collagen to cells of S. aureus...
- A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor AChampion C S Deivanayagam
Center for Biophysical Sciences and Engineering, School of Optometry, 244 CBSE, 1025 18th Street South, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
EMBO J 21:6660-72. 2002....
- Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonizationLouise M O'Brien
Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College Dublin, Dublin 2, Ireland
Cell Microbiol 4:759-70. 2002..We also showed that ClfB is transcribed by S. aureus in the human nares. We propose that ClfB is a major determinant in S. aureus nasal colonization...
- Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like proteinMaria A Schumacher
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201 3098, USA
EMBO J 21:3546-56. 2002..Such binding suggests a mechanism for Hfq function...
- Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein ALouise O'Brien
Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
Mol Microbiol 44:1033-44. 2002..aureus. Thus, S. aureus has multiple mechanisms for stimulating platelet aggregation. Such functional redundancy suggests that this phenomenon may be important in the pathogenesis of invasive diseases such as infective endocarditis...
- Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureusQue Chi Truong-Bolduc
Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2696, USA
J Bacteriol 185:3127-38. 2003..Collectively, these results indicate that NorR is a multifunctional regulator, affecting cell surface properties as well as the expression of NorA and likely other multidrug resistance efflux pumps...
- Expression, purification, and characterization of peptidyl-tRNA hydrolase from Staphylococcus aureusPaul D Bonin
Cell and Molecular Biology, Rockville, Maryland, USA
Protein Expr Purif 24:123-30. 2002..aureus Pth was determined to be 2.8 microM. A far UV circular dichroism spectrum revealed that His-tagged S. aureus Pth appears to have a structured core predominated by beta-sheet...
- Molecular characterization of a chromosomal locus in Staphylococcus aureus that contributes to oxidative defence and is highly induced by the cell-wall-active antibiotic oxacillinV K Singh
Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, IL 61790, USA
Microbiology 147:3037-45. 2001..An insertional knockout mutation in the first gene of this operon resulted in increased susceptibility of the mutant to H2O2 compared to the parent strain, but not to oxacillin...
- Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureusM Bischoff
Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
J Bacteriol 183:5171-9. 2001..The data presented here suggest that sigma(B) increases sar expression while simultaneously reducing the RNAIII level in a growth phase-dependent manner...
- Identification, cloning, and expression of a functional phenylalanyl-tRNA synthetase (pheRS) from Staphylococcus aureusJ W Savopoulos
GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park North, Coldharbour Road, Harlow, Essex CM19 5AD, United Kingdom
Protein Expr Purif 21:470-84. 2001..aureus (Oxford Strain) and demonstrate that Michaelis-Menten parameters for both recombinant and native enzyme, at least for phenylalanine tRNA aminoacylation are comparable...
- An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190K Kaneda
Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
Proc Natl Acad Sci U S A 98:932-7. 2001..aureus and of the different enzymatic properties of mammalian (type 1) and S. aureus (type 2) isomerases, this unusual enzyme is considered to be a suitable molecular target for the screening of antibacterial drugs specific to S. aureus...
- The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR moleculesM Håkansson
Molecular Biophysics, Centre for Chemistry and Chemical Engineering, Lund University, Lund, S 221 00, Sweden
J Mol Biol 302:527-37. 2000..Since the T-cell receptor probably interacts with both domains, SEH by this rotation may modulate its binding to different TcR Vbeta-chains...
- Modification of autolysis by synthetic peptides derived from the presumptive binding domain of Staphylococcus aureus autolysinM Takano
Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co, Ltd, Saitama, Japan
Microbiol Immunol 44:463-72. 2000..aureus autolysin activities. These peptides, especially the 10-mer peptide B9 (PGTKLYTVPW) that represents the C-terminal half of A10 and N-terminal half of A11, may be important segments for Atl to bind to the cell surface...
- Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureusM T Sebulsky
Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada, N6A 5C1
J Bacteriol 182:4394-400. 2000..By using the Fur titration assay, it was shown that the Fur box sequences upstream of fhuCBG are recognized by the Escherichia coli Fur protein...
- Isolation and mutation site determination of the temperature-sensitive murB mutants of Staphylococcus aureusMiki Matsuo
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 3 1, 7 chome, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
FEMS Microbiol Lett 222:107-13. 2003..These results suggest that the murB gene is essential for growth of S. aureus and that domain 3 is important for the MurB activity...
- Crystal structure of the SarS protein from Staphylococcus aureusRonggui Li
Integrated Department of Immunology, National Jewish Medical and Research Center, and Department of Pharmacology, Biomolecular Structure Program, School of Medicine, University of Colorado Health Science Center, Denver, Colorado 80206, USA
J Bacteriol 185:4219-25. 2003..Based on the structural differences of SarR, SarS, and MarR, we further classified these winged-helix proteins to three subfamilies, SarA, SarS, and MarR. Finally, a possible transcription regulation mechanism is proposed...
- Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetaseAlfredo Torres-Larios
Laboratoire de Biologie et Genomique Structurales, IGBMC, 1 rue Laurent Fries, BP 10142, 67400 Illkirch Cedex, France
J Mol Biol 331:201-11. 2003..The structural analysis suggests that, while the small substrates can bind in any order, they must be in place before productive tRNA binding can occur...
- MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuationJutta Rossi
Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
Antimicrob Agents Chemother 47:2558-64. 2003..These observations suggest that MsrR is a new component involved in sarA attenuation and the regulatory network controlling virulence gene expression in S. aureus...
- Transcriptional regulation of the Staphylococcus aureus thioredoxin and thioredoxin reductase genes in response to oxygen and disulfide stressOrit Uziel
Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
J Bacteriol 186:326-34. 2004..This observation, coupled with structural differences between the bacterial and mammalian thioredoxin reductases, suggests that it may serve as a target for the development of new antimicrobials...
- Genetic analysis of 17 genes in Staphylococcus aureus with reduced susceptibility to vancomycin (VISA) and heteroVISAM Wootton
J Antimicrob Chemother 53:406-7. 2004
- Expression of staphylococcal clumping factor A impedes macrophage phagocytosisNiklas Palmqvist
Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10 A, S 413 46 Goteborg, Sweden
Microbes Infect 6:188-95. 2004..Both the protection against phagocytosis and the enhanced immunostimulatory activity provided by ClfA expression are likely to contribute to the in vivo virulence of S. aureus...
- Regulatory elements of the Staphylococcus aureus protein A (Spa) promoterJinxin Gao
Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA
J Bacteriol 186:3738-48. 2004..Full repression required the presence of a second consensus site adjacent to the SarS binding site. Sequences directly upstream of the core promoter sequence were found to stimulate transcription...
- Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport proteinGlenn W Kaatz
The John D Dingell Department of Veteran s Affairs Medical Center, Detroit, MI 48201, USA
Antimicrob Agents Chemother 49:1857-64. 2005..MepR overexpression reversed the MDR phenotypes of both mutants by repressing mepA transcription. All three ORFs are preferentially transcribed as a single mepRAB unit, suggesting that the three genes form an operon...
- Structure and biosynthesis of staphyloxanthin from Staphylococcus aureusAlexandra Pelz
Department of Microbial Genetics, University of Tuebingen, Germany
J Biol Chem 280:32493-8. 2005..Staphyloxanthin was identified as beta-D-glucopyranosyl 1-O-(4,4'-diaponeurosporen-4-oate)-6-O-(12-methyltetradecanoate)...
- SarA positively controls bap-dependent biofilm formation in Staphylococcus aureusMaria Pilar Trotonda
Instituto Valenciano de Investigaciones Agrarias, Carretera Náquera Moncada Km 4, 5, 46113 Moncada, Valencia, Spain
J Bacteriol 187:5790-8. 2005..Based on the previous studies of others as well as our work demonstrating the role for SarA in icaADBC and bap expression, we propose that SarA is an essential regulator controlling biofilm formation in S. aureus...
- Successful multiresistant community-associated methicillin-resistant Staphylococcus aureus lineage from Taipei, Taiwan, that carries either the novel Staphylococcal chromosome cassette mec (SCCmec) type VT or SCCmec type IVSusan Boyle-Vavra
Department of Pediatrics, Section of Infectious Diseases, University of Chicago, IL, 60637, USA
J Clin Microbiol 43:4719-30. 2005..SCCmec V(T) is a novel SCCmec variant that is found in multiply resistant CAMRSA strains with sequence type 59 in Taipei in association with the PVL leukotoxin genes...
- A subset of Staphylococcus aureus strains harboring staphylococcal cassette chromosome mec (SCCmec) type IV is deficient in CcrAB-mediated SCCmec excisionMichael J Noto
Department of Microbiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0565, USA
Antimicrob Agents Chemother 50:2782-8. 2006..Acquisition of this mobile element, containing a known virulence gene, appears to have stabilized the chromosomal integration of the methicillin resistance gene in these strains...
- Direct hemin transfer from IsdA to IsdC in the iron-regulated surface determinant (Isd) heme acquisition system of Staphylococcus aureusMengyao Liu
Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana 59718, USA
J Biol Chem 283:6668-76. 2008....
- Structural characterization of the alpha-hemolysin monomer from Staphylococcus aureusChristian Meesters
Institute of Molecular Biophysics, University of Mainz, Mainz, Germany
Proteins 75:118-26. 2009..This structure reveals details of the monomeric conformation of the alpha-hemolysin, for example inherent flexibility, along with definite differences in comparison to the structures used as templates...
- The phosphoenolpyruvate:sugar phosphotransferase system in gram-positive bacteria: properties, mechanism, and regulationJ Reizer
Department of Biology, University of California at San Diego, La Jolla
Crit Rev Microbiol 15:297-338. 1988....
- A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-L-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterizationT Oshida
Rockefeller University, New York, NY 10021
Proc Natl Acad Sci U S A 92:285-9. 1995..aureus...
- Catalase deficiency in Staphylococcus aureus subsp. anaerobius is associated with natural loss-of-function mutations within the structural geneR Sanz
Departamento Patologia Animal I, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
Microbiology 146:465-75. 2000..aureus subsp. anaerobius, as deduced from results obtained with chimeric catalase constructs...
- Crystal structure of the superantigen staphylococcal enterotoxin type AE M Schad
Molecular Biophysics, Chemical Centre, Lund University
EMBO J 14:3292-301. 1995..Four amino acids including Ser1, His187, His225 and Asp227 were found to be involved in direct coordination of the metal ion. SEA is the first Zn2+ binding enterotoxin that has been structurally determined...
- Identification of the active-site nucleophile in 6-phospho-beta-galactosidase from Staphylococcus aureus by labelling with synthetic inhibitorsP Staedtler
Arbeitsgruppe Physiologie der Mikroorganismen, Abteilung Biologie, Ruhr Universitat Bochum, Germany
Eur J Biochem 232:658-63. 1995..It was shown to be identical to an authentic, synthetic sample. From this, it is evident that E375 is the active-site nucleophile of 6-phospho-galactosidase, consistent with previous findings for enzymes in this family...
- A homologue to the Escherichia coli alkyl hydroperoxide reductase AhpC is induced by osmotic upshock in Staphylococcus aureusL Armstrong-Buisseret
Department of Applied Biochemistry and Food Science, University of Nottingham, Faculty of Agricultural and Food Sciences, Leicestershire, UK
Microbiology 141:1655-61. 1995..Exposure of S. aureus to varying concentrations of H202 did not result in the detectable induction of AhpC...
- Primary sequence of the alpha-toxin gene from Staphylococcus aureus wood 46G S Gray
Infect Immun 46:615-8. 1984..The mature alpha-toxin protein had a molecular size of 33,000 and contained only three short regions of high hydrophobicity in addition to a number of short, weakly hydrophobic regions...
- A genetic system for analysis of staphylococcal nucleaseD Shortle
Gene 22:181-9. 1983..In combination with present methods for efficient in vitro mutagenesis, this plasmid-based genetic system can be applied to the detailed genetic analysis of this small, biochemically and biophysically well-characterized enzyme...
- Amino acid sequence of the amphiphilic phosphocarrier protein factor IIILac of the lactose-specific phosphotransferase system of StaphylococcusK Stuber
Biochemistry 24:1164-8. 1985..The N-terminal part of the protein comprising approximately one-third of the chain exhibits in vitro affinity toward membrane-bound enzyme IILac...
- Complete amino acid sequence of staphylococcal enterotoxin AI Y Huang
J Biol Chem 262:7006-13. 1987..and Bergdoll, M. S. (1970) J. Biol. Chem. 245, 3518-3525), and C1 (Schmidt, J. J., and Spero, L. (1983) J. Biol. Chem. 258, 6300-6306) than that seen between enterotoxins B and C1...
- Comparative biochemical and molecular analysis of the Staphylococcus hyicus, Staphylococcus aureus and a hybrid lipase. Indication for a C-terminal phospholipase domainK Nikoleit
Universitat Tubingen, Germany
Eur J Biochem 228:732-8. 1995..hyicus lipase. The fact that two closely related enzymes differ in the need for Ca2+ underscores the notion that it plays a structural rather than a catalytic role...
- Nucleotide sequence analysis of the gene for protein A from Staphylococcus aureus Cowan 1 (NCTC8530) and its enhanced expression in Escherichia coliH L Shuttleworth
Microbial Technology Laboratory, PHLS, Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wilts, U K
Gene 58:283-95. 1987..The homology to the latter probably identifies the Fc-binding region in the immunoglobulin-binding domains of SPA. Enhanced production of SPA in Escherichia coli was achieved using the lac promoter immediately upstream from the spa gene...
- Nucleotide sequence of the type C3 staphylococcal enterotoxin gene suggests that intergenic recombination causes antigenic variationJ L Couch
Department of Bacteriology, University of Wisconsin Madison 53706
J Bacteriol 171:4507-10. 1989..Sequence comparisons between the entC3, entC1, and entB genes suggest that an ancestral entC1-like gene was formed by recombination between the entC3 and entB genes...
- A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureusY Ohshita
Department of Microbiology, Faculty of Medicine, Juntendo University, Tokyo, Japan
Biochem Biophys Res Commun 172:1028-34. 1990....
- Complete nucleotide sequence of IS431mec in Staphylococcus aureusL Barberis-Maino
Institute of Medical Microbiology, University of Zurich, Switzerland
Nucleic Acids Res 18:5548. 1990
- A general method for cloning recA genes of gram-positive bacteria by polymerase chain reactionP Duwat
Laboratoire de Genetique Microbienne, Institut National de la Recherche Agronomique, Jouy en Josas, France
J Bacteriol 174:5171-5. 1992..This method is particularly useful for the recovery of the recA genes of gram-positive bacteria and avoids the difficulties of using a genetic complementation test for cloning...
- Functional expression of the alpha-hemolysin of Staphylococcus aureus in intact Escherichia coli and in cell lysates. Deletion of five C-terminal amino acids selectively impairs hemolytic activityB Walker
Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545
J Biol Chem 267:10902-9. 1992..The mutant polypeptide nevertheless binds tightly to erythrocytes as a monomer, strengthening the idea that oligomerization is required for cell lysis...
- Cleavage of human immunoglobulins by serine proteinase from Staphylococcus aureusL Prokesova
Laboratory of Special Medical Microbiology and Immunology, 1st Medical Faculty, Charles University, Studnickova, Prague, Czechoslovakia
Immunol Lett 31:259-65. 1992..SP has to be considered as one of the virulence factors of S. aureus that may protect bacteria against the defence mechanisms of the host...
- Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agrA L Cheung
Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, NY 10021
Proc Natl Acad Sci U S A 89:6462-6. 1992..aureus strain with a genetic background similar to strain 8325-4. This locus on the S. aureus chromosome, possibly regulatory in nature, has been designated sar for staphylococcal accessory regulator...
- Molecular evolution of the staphylococcal and streptococcal pyrogenic toxin gene familyR A Van Den Bussche
Department of Biological Sciences, University of Idaho, Moscow 83843
Mol Phylogenet Evol 2:281-92. 1993....
- Antibacterial action of extracellular mammalian group IIA phospholipase A2 against grossly clumped Staphylococcus aureusM E Dominiecki
Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
Infect Immun 67:2299-305. 1999..Thus, the extracellular mobilization of group IIA PLA2 during inflammation may provide a mechanism by which the host can control the proliferation and survival of S. aureus even after bacterial clumping...
- Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureusN Noguchi
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
FEMS Microbiol Lett 172:247-53. 1999..Our results indicated that four or more antiseptic-resistance genes exist in methicillin-resistant S. aureus and that antiseptic-resistant methicillin-resistant S. aureus strains without qacA and smr are widely spread in Japan...
- Identification and characterization of SirA, an iron-regulated protein from Staphylococcus aureusJ H Heinrichs
MedImmune, Inc, Gaithersburg, Maryland 20878, USA
J Bacteriol 181:1436-43. 1999..aureus culture medium. sir-encoded proteins may be involved in iron acquisition in vivo and therefore may be targets for antimicrobial agents...
- Transcriptional analysis of the Staphylococcus aureus penicillin binding protein 2 geneM G Pinho
Laboratory of Microbiology, The Rockefeller University, New York, New York 10021, USA
J Bacteriol 180:6077-81. 1998..We now show that introduction of the intact pbp2 gene with its two newly identified promoters into the chromosome of the transposon mutant resulted in the full recovery of high-level methicillin resistance...
- Clumping factor B (ClfB), a new surface-located fibrinogen-binding adhesin of Staphylococcus aureusD Ni Eidhin
Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
Mol Microbiol 30:245-57. 1998....
- Characterization of a novel structural member, LukE-LukD, of the bi-component staphylococcal leucotoxins familyA Gravet
UPRES EA 1318, Institut de Bacteriologie de la Faculte de Medecine, Université Louis Pasteur Hôpitaux Universitaires de Strasbourg, France
FEBS Lett 436:202-8. 1998..005). LukE+LukD was as effective as the Panton-Valentine leucocidin for inducing dermonecrosis when injected in the rabbit skin, but not hemolytic and poorly leucotoxic compared to other leucotoxins expressed by Staphylococcus aureus...
- Subcellular localization of the major autolysin, ATL and its processed proteins in Staphylococcus aureusH Komatsuzawa
Department of Microbiology, Hiroshima University School of Dentistry, Japan
Microbiol Immunol 41:469-79. 1997..We suggest that the 138-kDa ATL undergoes processing through intermediate proteins (115- and 85-kDa proteins) to mature as the active cell cluster-dispersing enzymes 51-kDa GL and 62-kDa AM on the cell surface...
- Glutamine synthetase and heteroresistance in methicillin-resistant Staphylococcus aureusA M Stranden
Institute of Medical Microbiology, University of Zurich, Switzerland
Microb Drug Resist 2:201-7. 1996..This suggests that S. aureus can adopt multiple ways to achieve high methicillin resistance...
- Localized perforation of the cell wall by a major autolysin: atl gene products and the onset of penicillin-induced lysis of Staphylococcus aureusM Sugai
Department of Microbiology, Hiroshima University School of Dentistry, Japan
J Bacteriol 179:2958-62. 1997....
- Staphylococcus aureus penicillin-binding protein 4 and intrinsic beta-lactam resistanceU U Henze
Institute of Medical Microbiology, University of Zurich, Switzerland
Antimicrob Agents Chemother 39:2415-22. 1995..The abcA-pbp4-tagD gene cluster was located in the SmaI-D fragment in the S. aureus 8325 chromosome in close proximity to the RNA polymerase gene rpoB...
- Histidine residues near the N terminus of staphylococcal alpha-toxin as reporters of regions that are critical for oligomerization and pore formationR Jursch
Institute of Medical Microbiology, University of Mainz, Germany
Infect Immun 62:2249-56. 1994..We interpret these results to indicate that the N-terminal domain of alpha-toxin in the region of H-35 and H-48 is involved in protomer-protomer interactions that underlie the hexamerization and pore-forming process...
- A genetic and molecular characterization of the recA gene from Staphylococcus aureusK W Bayles
Department of Biological Sciences, University of Maryland, Baltimore 21228
Gene 147:13-20. 1994..Furthermore, genetic and physical mapping of S. aureus recA placed it in the same region as the uvs-568 mutation. These data strongly suggest that these mutations represent different alleles of the same recA gene...
- Identification of a chromosomally encoded ABC-transport system with which the staphylococcal erythromycin exporter MsrA may interactJ I Ross
Department of Microbiology, University of Leeds, UK
Gene 153:93-8. 1995..There was no further sequence similarity outside these conserved regions. These results indicate that the chromosomes of S. hominis and S. aureus contain sequences encoding a potential TM protein with which MsrA might interact...
- Secretion of staphylococcal nuclease by Bacillus subtilisS Kovacevic
J Bacteriol 162:521-8. 1985..These findings indicate the prospective use of nuclease as a model system for studying secretion of heterologous proteins in B. subtilis...
- Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strainsXiao Xue Ma
Department of Bacteriology, Juntendo University, Tokyo, Japan
Antimicrob Agents Chemother 46:1147-52. 2002..Consistent with the strains' susceptibilities to various non-beta-lactam antibiotics, the type IV SCCmec was devoid of any antibiotic resistance genes other than the mecA gene...
- Identification and characterization of the PutP proline permease that contributes to in vivo survival of Staphylococcus aureus in animal modelsW R Schwan
PathoGenesis Corporation, Seattle, Washington 98119, USA
Infect Immun 66:567-72. 1998..aureus high-affinity proline permease suggests that proline scavenging by the bacteria is important for in vivo growth and proliferation and that analogs of proline may serve as potential antistaphylococcal therapeutic agents...
- Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane poreL Song
Department of Biochemistry, University of Chicago, 920 East 58 Street, Chicago, IL 60637, USA
Science 274:1859-66. 1996....
- Novel non-mecA-containing staphylococcal chromosomal cassette composite island containing pbp4 and tagF genes in a commensal staphylococcal species: a possible reservoir for antibiotic resistance islands in Staphylococcus aureusKanokporn Mongkolrattanothai
Section of Pediatric Infectious Diseases, Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
Antimicrob Agents Chemother 48:1823-36. 2004..In view of the fact that SCC-CI was found in a commensal species, it may represent a reservoir for sequences involved in genetic shuffling between staphylococci and may contribute to the diversity found in SCC elements...
- Chromosome-determined zinc-responsible operon czr in Staphylococcus aureus strain 912M Kuroda
Department of Microbiology, Institute of Basic Medical Sciences, and College of Medical Technology, University of Tsukuba, Ibaraki, Japan
Microbiol Immunol 43:115-25. 1999..25 mg per g dry weight. The findings indicated that the novel operon czrAB should play a role in the transportation of zinc across the cell membrane to maintain the proper intracellular concentration...
- Staphylococcus aureus chromosomal mutation plaC1 amplifies plasmid pT181 by depressing synthesis of its negative-effector countertranscriptsS Iordanescu
Department of Plasmid Biology, Public Health Research Institute, New York, New York 10016
J Bacteriol 171:4831-5. 1989..In turn, the reduction in countertranscript synthesis leads to an increase in the production of the initiator protein RepC, which is limiting for plasmid replication, and a higher plasmid copy number...
- Gordon Research Conference on Staphylococcal DiseasesBRIGITTE BERGER BACHI; Fiscal Year: 2003..S. This will afford a unique and rich opportunity for fellowship and scientific exchange between young and established investigators in the field. ..
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