Staphylococcus aureus subsp. aureus MSSA476

Summary

Alias: Staphylococcus aureus subsp. aureus str. MSSA476, Staphylococcus aureus subsp. aureus strain MSSA476

Top Publications

  1. pmc Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus
    Que Chi Truong-Bolduc
    Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    J Bacteriol 185:3127-38. 2003
  2. pmc Antibacterial action of extracellular mammalian group IIA phospholipase A2 against grossly clumped Staphylococcus aureus
    M E Dominiecki
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Infect Immun 67:2299-305. 1999
  3. pmc Cloning and expression of cadD, a new cadmium resistance gene of Staphylococcus aureus
    S S Crupper
    Division of Biological Sciences, Emporia State University, Emporia, Kansas 66801, USA
    J Bacteriol 181:4071-5. 1999
  4. ncbi Catalase deficiency in Staphylococcus aureus subsp. anaerobius is associated with natural loss-of-function mutations within the structural gene
    R Sanz
    Departamento Patologia Animal I, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Microbiology 146:465-75. 2000
  5. pmc Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureus
    M T Sebulsky
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Bacteriol 182:4394-400. 2000
  6. ncbi Modification of autolysis by synthetic peptides derived from the presumptive binding domain of Staphylococcus aureus autolysin
    M Takano
    Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co, Ltd, Saitama, Japan
    Microbiol Immunol 44:463-72. 2000
  7. ncbi The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR molecules
    M Håkansson
    Molecular Biophysics, Centre for Chemistry and Chemical Engineering, Lund University, Lund, S 221 00, Sweden
    J Mol Biol 302:527-37. 2000
  8. pmc An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190
    K Kaneda
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 98:932-7. 2001
  9. ncbi Identification, cloning, and expression of a functional phenylalanyl-tRNA synthetase (pheRS) from Staphylococcus aureus
    J W Savopoulos
    GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park North, Coldharbour Road, Harlow, Essex CM19 5AD, United Kingdom
    Protein Expr Purif 21:470-84. 2001
  10. pmc Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus
    M Bischoff
    Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
    J Bacteriol 183:5171-9. 2001

Research Grants

  1. Gordon Research Conference on Staphylococcal Diseases
    BRIGITTE BERGER BACHI; Fiscal Year: 2003

Patents

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
  2. Plants with increased yield
  3. Process for the production of a fine chemical
  4. Process for the production of lutein
  5. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
  6. Process for the production of fine chemicals
  7. Process for the control of production of fine chemicals
  8. Proteins associated with abiotic stress response and homologs
  9. Proteins associated with abiotic stress response and homologs
  10. Process for the production of a fine chemical

Scientific Experts

Detail Information

Publications62

  1. pmc Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus
    Que Chi Truong-Bolduc
    Division of Infectious Diseases and Medical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    J Bacteriol 185:3127-38. 2003
    ..Collectively, these results indicate that NorR is a multifunctional regulator, affecting cell surface properties as well as the expression of NorA and likely other multidrug resistance efflux pumps...
  2. pmc Antibacterial action of extracellular mammalian group IIA phospholipase A2 against grossly clumped Staphylococcus aureus
    M E Dominiecki
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Infect Immun 67:2299-305. 1999
    ..Thus, the extracellular mobilization of group IIA PLA2 during inflammation may provide a mechanism by which the host can control the proliferation and survival of S. aureus even after bacterial clumping...
  3. pmc Cloning and expression of cadD, a new cadmium resistance gene of Staphylococcus aureus
    S S Crupper
    Division of Biological Sciences, Emporia State University, Emporia, Kansas 66801, USA
    J Bacteriol 181:4071-5. 1999
    ..Moreover, the truncated version of cadX contained in pRW001 is nonfunctional and may have been generated by deletion during recombination to acquire the cadmium resistance element...
  4. ncbi Catalase deficiency in Staphylococcus aureus subsp. anaerobius is associated with natural loss-of-function mutations within the structural gene
    R Sanz
    Departamento Patologia Animal I, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Microbiology 146:465-75. 2000
    ..aureus subsp. anaerobius, as deduced from results obtained with chimeric catalase constructs...
  5. pmc Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureus
    M T Sebulsky
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Bacteriol 182:4394-400. 2000
    ..By using the Fur titration assay, it was shown that the Fur box sequences upstream of fhuCBG are recognized by the Escherichia coli Fur protein...
  6. ncbi Modification of autolysis by synthetic peptides derived from the presumptive binding domain of Staphylococcus aureus autolysin
    M Takano
    Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co, Ltd, Saitama, Japan
    Microbiol Immunol 44:463-72. 2000
    ..aureus autolysin activities. These peptides, especially the 10-mer peptide B9 (PGTKLYTVPW) that represents the C-terminal half of A10 and N-terminal half of A11, may be important segments for Atl to bind to the cell surface...
  7. ncbi The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR molecules
    M Håkansson
    Molecular Biophysics, Centre for Chemistry and Chemical Engineering, Lund University, Lund, S 221 00, Sweden
    J Mol Biol 302:527-37. 2000
    ..Since the T-cell receptor probably interacts with both domains, SEH by this rotation may modulate its binding to different TcR Vbeta-chains...
  8. pmc An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190
    K Kaneda
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 98:932-7. 2001
    ..aureus and of the different enzymatic properties of mammalian (type 1) and S. aureus (type 2) isomerases, this unusual enzyme is considered to be a suitable molecular target for the screening of antibacterial drugs specific to S. aureus...
  9. ncbi Identification, cloning, and expression of a functional phenylalanyl-tRNA synthetase (pheRS) from Staphylococcus aureus
    J W Savopoulos
    GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park North, Coldharbour Road, Harlow, Essex CM19 5AD, United Kingdom
    Protein Expr Purif 21:470-84. 2001
    ..aureus (Oxford Strain) and demonstrate that Michaelis-Menten parameters for both recombinant and native enzyme, at least for phenylalanine tRNA aminoacylation are comparable...
  10. pmc Influence of a functional sigB operon on the global regulators sar and agr in Staphylococcus aureus
    M Bischoff
    Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
    J Bacteriol 183:5171-9. 2001
    ..The data presented here suggest that sigma(B) increases sar expression while simultaneously reducing the RNAIII level in a growth phase-dependent manner...
  11. ncbi Molecular characterization of a chromosomal locus in Staphylococcus aureus that contributes to oxidative defence and is highly induced by the cell-wall-active antibiotic oxacillin
    V K Singh
    Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, IL 61790, USA
    Microbiology 147:3037-45. 2001
    ..An insertional knockout mutation in the first gene of this operon resulted in increased susceptibility of the mutant to H2O2 compared to the parent strain, but not to oxacillin...
  12. ncbi Expression, purification, and characterization of peptidyl-tRNA hydrolase from Staphylococcus aureus
    Paul D Bonin
    Cell and Molecular Biology, Rockville, Maryland, USA
    Protein Expr Purif 24:123-30. 2002
    ..aureus Pth was determined to be 2.8 microM. A far UV circular dichroism spectrum revealed that His-tagged S. aureus Pth appears to have a structured core predominated by beta-sheet...
  13. ncbi Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A
    Louise O'Brien
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 44:1033-44. 2002
    ..aureus. Thus, S. aureus has multiple mechanisms for stimulating platelet aggregation. Such functional redundancy suggests that this phenomenon may be important in the pathogenesis of invasive diseases such as infective endocarditis...
  14. pmc Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein
    Maria A Schumacher
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97201 3098, USA
    EMBO J 21:3546-56. 2002
    ..Such binding suggests a mechanism for Hfq function...
  15. ncbi Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization
    Louise M O'Brien
    Moyne Institute of Preventive Medicine, Department of Microbiology, Trinity College Dublin, Dublin 2, Ireland
    Cell Microbiol 4:759-70. 2002
    ..We also showed that ClfB is transcribed by S. aureus in the human nares. We propose that ClfB is a major determinant in S. aureus nasal colonization...
  16. pmc A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factor A
    Champion C S Deivanayagam
    Center for Biophysical Sciences and Engineering, School of Optometry, 244 CBSE, 1025 18th Street South, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    EMBO J 21:6660-72. 2002
    ....
  17. ncbi Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureus
    N Noguchi
    Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
    FEMS Microbiol Lett 172:247-53. 1999
    ..Our results indicated that four or more antiseptic-resistance genes exist in methicillin-resistant S. aureus and that antiseptic-resistant methicillin-resistant S. aureus strains without qacA and smr are widely spread in Japan...
  18. ncbi Isolation and mutation site determination of the temperature-sensitive murB mutants of Staphylococcus aureus
    Miki Matsuo
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 3 1, 7 chome, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FEMS Microbiol Lett 222:107-13. 2003
    ..These results suggest that the murB gene is essential for growth of S. aureus and that domain 3 is important for the MurB activity...
  19. pmc Crystal structure of the SarS protein from Staphylococcus aureus
    Ronggui Li
    Integrated Department of Immunology, National Jewish Medical and Research Center, and Department of Pharmacology, Biomolecular Structure Program, School of Medicine, University of Colorado Health Science Center, Denver, Colorado 80206, USA
    J Bacteriol 185:4219-25. 2003
    ..Based on the structural differences of SarR, SarS, and MarR, we further classified these winged-helix proteins to three subfamilies, SarA, SarS, and MarR. Finally, a possible transcription regulation mechanism is proposed...
  20. ncbi Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase
    Alfredo Torres-Larios
    Laboratoire de Biologie et Genomique Structurales, IGBMC, 1 rue Laurent Fries, BP 10142, 67400 Illkirch Cedex, France
    J Mol Biol 331:201-11. 2003
    ..The structural analysis suggests that, while the small substrates can bind in any order, they must be in place before productive tRNA binding can occur...
  21. pmc MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuation
    Jutta Rossi
    Institute of Medical Microbiology, University of Zurich, CH 8028 Zurich, Switzerland
    Antimicrob Agents Chemother 47:2558-64. 2003
    ..These observations suggest that MsrR is a new component involved in sarA attenuation and the regulatory network controlling virulence gene expression in S. aureus...
  22. pmc Molecular architecture of the regulatory Locus sae of Staphylococcus aureus and its impact on expression of virulence factors
    Andrea Steinhuber
    Allgemeine Hygiene und Umwelthygiene, Universitat Tubingen, Tubingen, Germany
    J Bacteriol 185:6278-86. 2003
    ..In summary, the sae operon constitutes a four-component regulator system which acts on virulence gene expression in S. aureus...
  23. pmc Transcriptional regulation of the Staphylococcus aureus thioredoxin and thioredoxin reductase genes in response to oxygen and disulfide stress
    Orit Uziel
    Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    J Bacteriol 186:326-34. 2004
    ..This observation, coupled with structural differences between the bacterial and mammalian thioredoxin reductases, suggests that it may serve as a target for the development of new antimicrobials...
  24. ncbi Genetic analysis of 17 genes in Staphylococcus aureus with reduced susceptibility to vancomycin (VISA) and heteroVISA
    M Wootton
    J Antimicrob Chemother 53:406-7. 2004
  25. ncbi Expression of staphylococcal clumping factor A impedes macrophage phagocytosis
    Niklas Palmqvist
    Department of Rheumatology and Inflammation Research, Goteborg University, Guldhedsgatan 10 A, S 413 46 Goteborg, Sweden
    Microbes Infect 6:188-95. 2004
    ..Both the protection against phagocytosis and the enhanced immunostimulatory activity provided by ClfA expression are likely to contribute to the in vivo virulence of S. aureus...
  26. pmc Regulatory elements of the Staphylococcus aureus protein A (Spa) promoter
    Jinxin Gao
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA
    J Bacteriol 186:3738-48. 2004
    ..Full repression required the presence of a second consensus site adjacent to the SarS binding site. Sequences directly upstream of the core promoter sequence were found to stimulate transcription...
  27. pmc Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein
    Glenn W Kaatz
    The John D Dingell Department of Veteran s Affairs Medical Center, Detroit, MI 48201, USA
    Antimicrob Agents Chemother 49:1857-64. 2005
    ..MepR overexpression reversed the MDR phenotypes of both mutants by repressing mepA transcription. All three ORFs are preferentially transcribed as a single mepRAB unit, suggesting that the three genes form an operon...
  28. ncbi Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus
    Alexandra Pelz
    Department of Microbial Genetics, University of Tuebingen, Germany
    J Biol Chem 280:32493-8. 2005
    ..Staphyloxanthin was identified as beta-D-glucopyranosyl 1-O-(4,4'-diaponeurosporen-4-oate)-6-O-(12-methyltetradecanoate)...
  29. pmc SarA positively controls bap-dependent biofilm formation in Staphylococcus aureus
    Maria Pilar Trotonda
    Instituto Valenciano de Investigaciones Agrarias, Carretera Náquera Moncada Km 4, 5, 46113 Moncada, Valencia, Spain
    J Bacteriol 187:5790-8. 2005
    ..Based on the previous studies of others as well as our work demonstrating the role for SarA in icaADBC and bap expression, we propose that SarA is an essential regulator controlling biofilm formation in S. aureus...
  30. pmc S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins
    Michael R Dorwart
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Texas, United States of America
    PLoS Biol 8:e1000555. 2010
    ....
  31. pmc Cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of an inositol monophosphatase family protein (SAS2203) from Staphylococcus aureus MSSA476
    Sudipta Bhattacharyya
    Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721 302, India
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:471-4. 2011
    ..The diffraction data were consistent with the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 49.98, b = 68.35, c = 143.79 Å, α = β = γ = 90°, and the crystal contained two molecules in the asymmetric unit...
  32. pmc A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-L-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterization
    T Oshida
    Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 92:285-9. 1995
    ..aureus...
  33. pmc Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agr
    A L Cheung
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 89:6462-6. 1992
    ..aureus strain with a genetic background similar to strain 8325-4. This locus on the S. aureus chromosome, possibly regulatory in nature, has been designated sar for staphylococcal accessory regulator...
  34. ncbi Cleavage of human immunoglobulins by serine proteinase from Staphylococcus aureus
    L Prokesova
    Laboratory of Special Medical Microbiology and Immunology, 1st Medical Faculty, Charles University, Studnickova, Prague, Czechoslovakia
    Immunol Lett 31:259-65. 1992
    ..SP has to be considered as one of the virulence factors of S. aureus that may protect bacteria against the defence mechanisms of the host...
  35. ncbi Functional expression of the alpha-hemolysin of Staphylococcus aureus in intact Escherichia coli and in cell lysates. Deletion of five C-terminal amino acids selectively impairs hemolytic activity
    B Walker
    Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545
    J Biol Chem 267:10902-9. 1992
    ..The mutant polypeptide nevertheless binds tightly to erythrocytes as a monomer, strengthening the idea that oligomerization is required for cell lysis...
  36. pmc A general method for cloning recA genes of gram-positive bacteria by polymerase chain reaction
    P Duwat
    Laboratoire de Genetique Microbienne, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Bacteriol 174:5171-5. 1992
    ..This method is particularly useful for the recovery of the recA genes of gram-positive bacteria and avoids the difficulties of using a genetic complementation test for cloning...
  37. ncbi Nucleotide sequence analysis of the gene for protein A from Staphylococcus aureus Cowan 1 (NCTC8530) and its enhanced expression in Escherichia coli
    H L Shuttleworth
    Microbial Technology Laboratory, PHLS, Centre for Applied Microbiology and Research, Porton Down, Salisbury, Wilts, U K
    Gene 58:283-95. 1987
    ..The homology to the latter probably identifies the Fc-binding region in the immunoglobulin-binding domains of SPA. Enhanced production of SPA in Escherichia coli was achieved using the lac promoter immediately upstream from the spa gene...
  38. ncbi The phosphoenolpyruvate:sugar phosphotransferase system in gram-positive bacteria: properties, mechanism, and regulation
    J Reizer
    Department of Biology, University of California at San Diego, La Jolla
    Crit Rev Microbiol 15:297-338. 1988
    ....
  39. ncbi Complete amino acid sequence of staphylococcal enterotoxin A
    I Y Huang
    J Biol Chem 262:7006-13. 1987
    ..and Bergdoll, M. S. (1970) J. Biol. Chem. 245, 3518-3525), and C1 (Schmidt, J. J., and Spero, L. (1983) J. Biol. Chem. 258, 6300-6306) than that seen between enterotoxins B and C1...
  40. pmc Secretion of staphylococcal nuclease by Bacillus subtilis
    S Kovacevic
    J Bacteriol 162:521-8. 1985
    ..These findings indicate the prospective use of nuclease as a model system for studying secretion of heterologous proteins in B. subtilis...
  41. ncbi Amino acid sequence of the amphiphilic phosphocarrier protein factor IIILac of the lactose-specific phosphotransferase system of Staphylococcus
    K Stuber
    Biochemistry 24:1164-8. 1985
    ..The N-terminal part of the protein comprising approximately one-third of the chain exhibits in vitro affinity toward membrane-bound enzyme IILac...
  42. ncbi A genetic system for analysis of staphylococcal nuclease
    D Shortle
    Gene 22:181-9. 1983
    ..In combination with present methods for efficient in vitro mutagenesis, this plasmid-based genetic system can be applied to the detailed genetic analysis of this small, biochemically and biophysically well-characterized enzyme...
  43. pmc Primary sequence of the alpha-toxin gene from Staphylococcus aureus wood 46
    G S Gray
    Infect Immun 46:615-8. 1984
    ..The mature alpha-toxin protein had a molecular size of 33,000 and contained only three short regions of high hydrophobicity in addition to a number of short, weakly hydrophobic regions...
  44. ncbi A homologue to the Escherichia coli alkyl hydroperoxide reductase AhpC is induced by osmotic upshock in Staphylococcus aureus
    L Armstrong-Buisseret
    Department of Applied Biochemistry and Food Science, University of Nottingham, Faculty of Agricultural and Food Sciences, Leicestershire, UK
    Microbiology 141:1655-61. 1995
    ..Exposure of S. aureus to varying concentrations of H202 did not result in the detectable induction of AhpC...
  45. ncbi Identification of the active-site nucleophile in 6-phospho-beta-galactosidase from Staphylococcus aureus by labelling with synthetic inhibitors
    P Staedtler
    Arbeitsgruppe Physiologie der Mikroorganismen, Abteilung Biologie, Ruhr Universitat Bochum, Germany
    Eur J Biochem 232:658-63. 1995
    ..It was shown to be identical to an authentic, synthetic sample. From this, it is evident that E375 is the active-site nucleophile of 6-phospho-galactosidase, consistent with previous findings for enzymes in this family...
  46. pmc Crystal structure of the superantigen staphylococcal enterotoxin type A
    E M Schad
    Molecular Biophysics, Chemical Centre, Lund University
    EMBO J 14:3292-301. 1995
    ..Four amino acids including Ser1, His187, His225 and Asp227 were found to be involved in direct coordination of the metal ion. SEA is the first Zn2+ binding enterotoxin that has been structurally determined...
  47. ncbi Comparative biochemical and molecular analysis of the Staphylococcus hyicus, Staphylococcus aureus and a hybrid lipase. Indication for a C-terminal phospholipase domain
    K Nikoleit
    Universitat Tubingen, Germany
    Eur J Biochem 228:732-8. 1995
    ..hyicus lipase. The fact that two closely related enzymes differ in the need for Ca2+ underscores the notion that it plays a structural rather than a catalytic role...
  48. ncbi Molecular characterization and expression of a gene encoding a Staphylococcus aureus collagen adhesin
    J M Patti
    Department of Biochemistry, University of Alabama, Birmingham 35294 0005
    J Biol Chem 267:4766-72. 1992
    ..Finally, the bacterial lysate containing the recombinant adhesin can effectively inhibit the binding of soluble collagen to cells of S. aureus...
  49. ncbi Identification of a chromosomally encoded ABC-transport system with which the staphylococcal erythromycin exporter MsrA may interact
    J I Ross
    Department of Microbiology, University of Leeds, UK
    Gene 153:93-8. 1995
    ..There was no further sequence similarity outside these conserved regions. These results indicate that the chromosomes of S. hominis and S. aureus contain sequences encoding a potential TM protein with which MsrA might interact...
  50. ncbi A genetic and molecular characterization of the recA gene from Staphylococcus aureus
    K W Bayles
    Department of Biological Sciences, University of Maryland, Baltimore 21228
    Gene 147:13-20. 1994
    ..Furthermore, genetic and physical mapping of S. aureus recA placed it in the same region as the uvs-568 mutation. These data strongly suggest that these mutations represent different alleles of the same recA gene...
  51. pmc Histidine residues near the N terminus of staphylococcal alpha-toxin as reporters of regions that are critical for oligomerization and pore formation
    R Jursch
    Institute of Medical Microbiology, University of Mainz, Germany
    Infect Immun 62:2249-56. 1994
    ..We interpret these results to indicate that the N-terminal domain of alpha-toxin in the region of H-35 and H-48 is involved in protomer-protomer interactions that underlie the hexamerization and pore-forming process...
  52. pmc Staphylococcus aureus penicillin-binding protein 4 and intrinsic beta-lactam resistance
    U U Henze
    Institute of Medical Microbiology, University of Zurich, Switzerland
    Antimicrob Agents Chemother 39:2415-22. 1995
    ..The abcA-pbp4-tagD gene cluster was located in the SmaI-D fragment in the S. aureus 8325 chromosome in close proximity to the RNA polymerase gene rpoB...
  53. ncbi Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore
    L Song
    Department of Biochemistry, University of Chicago, 920 East 58 Street, Chicago, IL 60637, USA
    Science 274:1859-66. 1996
    ....
  54. pmc Localized perforation of the cell wall by a major autolysin: atl gene products and the onset of penicillin-induced lysis of Staphylococcus aureus
    M Sugai
    Department of Microbiology, Hiroshima University School of Dentistry, Japan
    J Bacteriol 179:2958-62. 1997
    ....
  55. ncbi Glutamine synthetase and heteroresistance in methicillin-resistant Staphylococcus aureus
    A M Stranden
    Institute of Medical Microbiology, University of Zurich, Switzerland
    Microb Drug Resist 2:201-7. 1996
    ..This suggests that S. aureus can adopt multiple ways to achieve high methicillin resistance...
  56. ncbi Subcellular localization of the major autolysin, ATL and its processed proteins in Staphylococcus aureus
    H Komatsuzawa
    Department of Microbiology, Hiroshima University School of Dentistry, Japan
    Microbiol Immunol 41:469-79. 1997
    ..We suggest that the 138-kDa ATL undergoes processing through intermediate proteins (115- and 85-kDa proteins) to mature as the active cell cluster-dispersing enzymes 51-kDa GL and 62-kDa AM on the cell surface...
  57. pmc Staphylococcus aureus cap5O and cap5P genes functionally complement mutations affecting enterobacterial common-antigen biosynthesis in Escherichia coli
    K B Kiser
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bacteriol 180:403-6. 1998
    ..Cap5P and Cap5O likely function as UDP-GlcNAc 2-epimerase and UDP-ManNAc dehydrogenase enzymes, respectively, in the synthesis of the capsule precursor UDP-ManNAcA...
  58. ncbi Characterization of a novel structural member, LukE-LukD, of the bi-component staphylococcal leucotoxins family
    A Gravet
    UPRES EA 1318, Institut de Bacteriologie de la Faculte de Medecine, Université Louis Pasteur Hôpitaux Universitaires de Strasbourg, France
    FEBS Lett 436:202-8. 1998
    ..005). LukE+LukD was as effective as the Panton-Valentine leucocidin for inducing dermonecrosis when injected in the rabbit skin, but not hemolytic and poorly leucotoxic compared to other leucotoxins expressed by Staphylococcus aureus...
  59. ncbi The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action
    M A Parry
    Max Planck Institute of Biochemistry, Department for Structural Research, Martinsried, Germany
    Nat Struct Biol 5:917-23. 1998
    ..Furthermore, it provides a template for the design of improved plasminogen activators and plasmin inhibitors with considerable therapeutical potential...
  60. ncbi Clumping factor B (ClfB), a new surface-located fibrinogen-binding adhesin of Staphylococcus aureus
    D Ni Eidhin
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 30:245-57. 1998
    ....
  61. pmc Transcriptional analysis of the Staphylococcus aureus penicillin binding protein 2 gene
    M G Pinho
    Laboratory of Microbiology, The Rockefeller University, New York, New York 10021, USA
    J Bacteriol 180:6077-81. 1998
    ..We now show that introduction of the intact pbp2 gene with its two newly identified promoters into the chromosome of the transposon mutant resulted in the full recovery of high-level methicillin resistance...
  62. pmc Identification and characterization of SirA, an iron-regulated protein from Staphylococcus aureus
    J H Heinrichs
    MedImmune, Inc, Gaithersburg, Maryland 20878, USA
    J Bacteriol 181:1436-43. 1999
    ..aureus culture medium. sir-encoded proteins may be involved in iron acquisition in vivo and therefore may be targets for antimicrobial agents...

Research Grants1

  1. Gordon Research Conference on Staphylococcal Diseases
    BRIGITTE BERGER BACHI; Fiscal Year: 2003
    ..S. This will afford a unique and rich opportunity for fellowship and scientific exchange between young and established investigators in the field. ..

Patents10

  1. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  2. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  3. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
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