Bacillus subtilis subsp. subtilis str. 168

Summary

Alias: Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700

Top Publications

  1. ncbi Replication initiation proteins regulate a developmental checkpoint in Bacillus subtilis
    W F Burkholder
    Department of Biology, Massachusetts Institute of Technology, Building 68, Room 530, Cambridge, MA 02139, USA
    Cell 104:269-79. 2001
  2. pmc Ribonucleases J1 and J2: two novel endoribonucleases in B.subtilis with functional homology to E.coli RNase E
    Sergine Even
    CNRS UPR9073, IBPC 13 rue P et M Curie, 75005 Paris, France
    Nucleic Acids Res 33:2141-52. 2005
  3. ncbi Processing of a sporulation sigma factor in Bacillus subtilis: how morphological structure could control gene expression
    P Stragier
    Institut de Microbiologie, Universite Paris Sud, Orsay, France
    Cell 52:697-704. 1988
  4. pmc Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis
    Shunji Nakano
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 100:13603-8. 2003
  5. ncbi Cannibalism by sporulating bacteria
    Jose E Gonzalez-Pastor
    Department of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 301:510-3. 2003
  6. pmc Global analysis of the general stress response of Bacillus subtilis
    A Petersohn
    Institut fur Mikrobiologie, Ernst Moritz Arndt Universitat, 17487 Greifswald, Deutsches Krebsforschungszentrum Heidelberg, 69120 Heidelberg, Germany
    J Bacteriol 183:5617-31. 2001
  7. pmc Helicase binding to DnaI exposes a cryptic DNA-binding site during helicase loading in Bacillus subtilis
    Charikleia Ioannou
    Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Nucleic Acids Res 34:5247-58. 2006
  8. ncbi The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis
    Stefanie Töwe
    Institute for Microbiology, Ernst Moritz Arndt University of Greifswald, F L Jahn Str 15, D 17487 Greifswald, Germany
    Mol Microbiol 66:40-54. 2007
  9. doi Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis
    Montira Leelakriangsak
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR, USA
    Mol Microbiol 67:1108-24. 2008
  10. ncbi Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in B. subtilis
    M Perego
    Dipartimento Farmaceutico, Universita degli Studi di Parma, Italy
    Cell 79:1047-55. 1994

Research Grants

  1. Meeting on the Pathogenesis of Clostridia
    ABRAHAM SONENSHEIN; Fiscal Year: 2003
  2. ABRB BINDING TO DEVELOPMENTALLY CONTROLLED PROMOTERS
    Mark Strauch; Fiscal Year: 2006
  3. Mechanism and Specificity in Manganese Homeostasis
    Arthur Glasfeld; Fiscal Year: 2007
  4. Regulation of hemolysin genes in Bacillus
    Michiko Nakano; Fiscal Year: 2007
  5. Clostridium difficile Toxin Gene Regulation
    ABRAHAM LINCOLN SONENSHEIN; Fiscal Year: 2010

Patents

  1. Enzymatic omega-oxidation and omega-amination of fatty acid
  2. Proteins associated with abiotic stress response and homologs
  3. Highly conserved genes and their use to generate probes and primers for detection of microorganisms
  4. Process for the production of a fine chemical
  5. Proteins associated with abiotic stress response and homologs
  6. RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES
  7. Process for producing dipeptides
  8. Process for producing dipeptides or dipeptide derivatives
  9. SURFACTANT AND CLEANING COMPOSITIONS COMPRISING MICROBIALLY PRODUCED BRANCHED FATTY ALCOHOLS
  10. ENZYMATIC OMEGA-OXIDATION AND OMEGA-AMINATION OF FATTY ACIDS

Detail Information

Publications260 found, 100 shown here

  1. ncbi Replication initiation proteins regulate a developmental checkpoint in Bacillus subtilis
    W F Burkholder
    Department of Biology, Massachusetts Institute of Technology, Building 68, Room 530, Cambridge, MA 02139, USA
    Cell 104:269-79. 2001
    ..Purified Sda inhibited a histidine kinase needed for activation of Spo0A. Our results indicate that control of sda by DnaA establishes a checkpoint that inhibits activation of Spo0A and prevents futile attempts to initiate sporulation...
  2. pmc Ribonucleases J1 and J2: two novel endoribonucleases in B.subtilis with functional homology to E.coli RNase E
    Sergine Even
    CNRS UPR9073, IBPC 13 rue P et M Curie, 75005 Paris, France
    Nucleic Acids Res 33:2141-52. 2005
    ..RNases J1/J2 appear to be implicated in regulatory processing/maturation of specific mRNAs, such as the T-box family members thrS and thrZ, but may also contribute to global mRNA degradation...
  3. ncbi Processing of a sporulation sigma factor in Bacillus subtilis: how morphological structure could control gene expression
    P Stragier
    Institut de Microbiologie, Universite Paris Sud, Orsay, France
    Cell 52:697-704. 1988
    ..According to this model, a morphological structure would directly control the synthesis of a developmental sigma factor and would modify gene expression...
  4. pmc Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis
    Shunji Nakano
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 100:13603-8. 2003
    ....
  5. ncbi Cannibalism by sporulating bacteria
    Jose E Gonzalez-Pastor
    Department of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 301:510-3. 2003
    ..We propose that sporulation is a stress-response pathway of last resort and that B. subtilis delays a commitment to spore formation by cannibalizing its siblings...
  6. pmc Global analysis of the general stress response of Bacillus subtilis
    A Petersohn
    Institut fur Mikrobiologie, Ernst Moritz Arndt Universitat, 17487 Greifswald, Deutsches Krebsforschungszentrum Heidelberg, 69120 Heidelberg, Germany
    J Bacteriol 183:5617-31. 2001
    ..Perhaps the most interesting of the sigma(B)-independent stress phenomena was the induction of the extracytoplasmic function sigma factor sigma(W) and its entire regulon by salt shock...
  7. pmc Helicase binding to DnaI exposes a cryptic DNA-binding site during helicase loading in Bacillus subtilis
    Charikleia Ioannou
    Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Nucleic Acids Res 34:5247-58. 2006
    ..DnaI is sufficient to load the replicative helicase from a complex with six DnaI molecules, so there is no requirement for a dual helicase loader system...
  8. ncbi The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilis
    Stefanie Töwe
    Institute for Microbiology, Ernst Moritz Arndt University of Greifswald, F L Jahn Str 15, D 17487 Greifswald, Germany
    Mol Microbiol 66:40-54. 2007
    ..Moreover, the DeltaykvE mutant displayed a 2-MHQ and catechol resistant phenotype. YkvE was renamed as MhqR controlling a 2-MHQ and catechol-resistance regulon of B. subtilis...
  9. doi Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis
    Montira Leelakriangsak
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR, USA
    Mol Microbiol 67:1108-24. 2008
    ..Thus, both azoreductases that are controlled by different regulatory mechanisms have common functions in quinone and azo-compound reduction to protect cells against the thiol reactivity of electrophiles...
  10. ncbi Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in B. subtilis
    M Perego
    Dipartimento Farmaceutico, Universita degli Studi di Parma, Italy
    Cell 79:1047-55. 1994
    ..The integration of diverse environmental signals that affect the initiation of sporulation likely occurs through the competition between opposing activities of protein kinases and protein phosphatases...
  11. doi Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR)
    Thi Thu Huyen Nguyen
    Institute for Microbiology, Ernst Moritz Arndt University of Greifswald, D 17487 Greifswald, Germany
    Mol Microbiol 71:876-94. 2009
    ..We speculate that AdhR is redox-regulated via thiol-(S)-alkylation by aldehydes and that AdhA and YraA are specifically involved in reduction of aldehydes and degradation or repair of damaged thiol-containing proteins respectively...
  12. ncbi Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis
    Hideaki Nanamiya
    Cell Free Science and Technology Research Center, Ehime University, Bunkyo cho, Matsuyama 790 8577, Japan
    Mol Microbiol 67:291-304. 2008
    ..The SAS proteins thus likely function in the biosynthesis of alarmone with a mode of action distinct from that of RelA-SpoT homologues...
  13. ncbi Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis
    Wiep Klaas Smits
    Groningen Biomolecular Sciences and Biotechnology Institute, Department of Genetics, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Mol Microbiol 65:103-20. 2007
    ..Together, these results indicate that RapH is an integral part of a multifactorial regulatory circuit affecting the cell's decision between distinct developmental pathways...
  14. pmc Homologous pairs of regulatory proteins control activity of Bacillus subtilis transcription factor sigma(b) in response to environmental stress
    C M Kang
    Department of Food Science and Technology, University of California, Davis 95616, USA
    J Bacteriol 178:3846-53. 1996
    ....
  15. pmc spo0J is required for normal chromosome segregation as well as the initiation of sporulation in Bacillus subtilis
    K Ireton
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    J Bacteriol 176:5320-9. 1994
    ..The dual functions of Spo0J could provide a mechanism for regulating the initiation of sporulation in response to activity of the chromosome partition machinery...
  16. pmc A conserved anti-repressor controls horizontal gene transfer by proteolysis
    Baundauna Bose
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Microbiol 70:570-82. 2008
    ..subtilis phage phi105 is required for inactivation of the phi105 repressor (an ImmR homologue). ImmA-dependent proteolysis of ImmR repressors may be a conserved mechanism for regulating horizontal gene transfer...
  17. pmc SigmaX is involved in controlling Bacillus subtilis biofilm architecture through the AbrB homologue Abh
    Ewan J Murray
    Division of Molecular Microbiology, College of Life Sciences, MSI WTB JBC Complex, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Bacteriol 191:6822-32. 2009
    ..Furthermore, Abh is shown to activate transcription from the promoter of the eps operon through its control of SlrR. These findings add to the increasingly complex transcriptional network that controls biofilm formation by B. subtilis...
  18. pmc Large ring polymers align FtsZ polymers for normal septum formation
    Muhammet E Gündoğdu
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle, UK
    EMBO J 30:617-26. 2011
    ..We propose that SepF rings are required for the regular arrangement of FtsZ filaments. Absence of this ordered state could explain the grossly distorted septal morphologies seen in sepF mutants...
  19. doi CtsR inactivation during thiol-specific stress in low GC, Gram+ bacteria
    Alexander K W Elsholz
    Institute of Microbiology, Ernst Moritz Arndt University Greifswald, F L Jahnstr 15, D 17487 Greifswald, Germany
    Mol Microbiol 79:772-85. 2011
    ..Moreover, we show that in those low GC, Gram+ bacteria, which lack the McsA/McsB complex, the Zn finger protein ClpE is able to sense and respond to oxidative stress, also resulting in CtsR inactivation...
  20. pmc Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels
    M Ratnayake-Lecamwasam
    Tufts University School of Medicine, Department of Molecular Biology and Microbiology, Boston, Massachusetts 02111, USA
    Genes Dev 15:1093-103. 2001
    ....
  21. pmc Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus subtilis
    P A Levin
    Department of Biology, Building 68 530, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 96:9642-7. 1999
    ..EzrA was associated with the cell membrane and also colocalized with FtsZ to the nascent septal site. We propose that EzrA interacts either with FtsZ or with one of its binding partners to promote depolymerization...
  22. pmc Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop
    Hédia Maamar
    Public Health Research Institute, 225 Warren Street, Newark NJ 07103, USA
    Mol Microbiol 56:615-24. 2005
    ..We further address the source of the noise that results in the stochastic selection of cells that will express comK. A revised model for the regulation of comK expression is proposed that partially explains bistability...
  23. pmc DnaB proteolysis in vivo regulates oligomerization and its localization at oriC in Bacillus subtilis
    William H Grainger
    Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Nucleic Acids Res 38:2851-64. 2010
    ..It encompasses an area from the middle of dnaA to the end of yaaA that includes the AT-rich region melted during the initiation stage of DNA replication...
  24. pmc Cloning, sequencing, and molecular analysis of the dnaK locus from Bacillus subtilis
    M Wetzstein
    Lehrstuhl fur Genetik, Universitat Bayreuth, Germany
    J Bacteriol 174:3300-10. 1992
    ..The biological property of this inverted repeat as a putative key element in the induction of heat shock genes is discussed. The dnaK locus was mapped at about 223 degrees on the B. subtilis genetic map...
  25. pmc The spoIIJ gene, which regulates early developmental steps in Bacillus subtilis, belongs to a class of environmentally responsive genes
    C Antoniewski
    Institut de Microbiologie, Universite Paris Sud, Orsay, France
    J Bacteriol 172:86-93. 1990
    ..Thus, spoIIj, which is transcribed during vegetative growth, presumably under the control of sigma H, encodes a protein that could interact with major regulators of early sporulation stages, such as SpoOA and/or SpoOF...
  26. pmc The sacT gene regulating the sacPA operon in Bacillus subtilis shares strong homology with transcriptional antiterminators
    M Debarbouille
    Unité de Biochimie Microbienne, Centre National de la Recherche Scientifique URA1300, Institut Pasteur, Paris, France
    J Bacteriol 172:3966-73. 1990
    ..It corresponds to a Asp-96-to-Tyr missense mutation located in a highly conserved region in SacT and SacY. These results strongly suggest that sacT is a specific regulatory gene of the sacPA operon...
  27. pmc Bacillus subtilis alpha-phosphoglucomutase is required for normal cell morphology and biofilm formation
    Vladimir Lazarevic
    Département de Microbiologie Fondamentale, Batiment de Biologie, Faculté de Biologie et de Médecine, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Appl Environ Microbiol 71:39-45. 2005
    ..The deficiency in biofilm formation in gtaC and gtaE mutants may be attributed to an inability to synthesize UDP-glucose, an important intermediate in a number of cell envelope biosynthetic processes...
  28. ncbi Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family
    Minsun Hong
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Cell 20:131-41. 2005
    ..The structure of the OhrR-ohrA operator complex reveals the DNA binding mechanism of the entire MarR family and suggests a common inducer binding pocket...
  29. pmc Circularly permuted GTPase YqeH binds 30S ribosomal subunit: Implications for its role in ribosome assembly
    Baskaran Anand
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India
    Biochem Biophys Res Commun 386:602-6. 2009
    ..Further, S5, a ribosomal protein which participates during the initial stages of 30S assembly, was found to promote GTP hydrolysis and RNA binding activities of YqeH...
  30. pmc Noise in gene expression determines cell fate in Bacillus subtilis
    Hédia Maamar
    Public Health Research Institute Center, New Jersey Medical School, 225 Warren Street, Newark, NJ 07103, USA
    Science 317:526-9. 2007
    ..These results illustrate how such stochastic transitions are regulated in a natural system and suggest that noise characteristics are subject to evolutionary forces...
  31. ncbi The structure of Bacillus subtilis pectate lyase in complex with calcium
    R Pickersgill
    Department of Protein Engineering, Institute of Food Research, Reading, UK
    Nat Struct Biol 1:717-23. 1994
    ..Calcium, essential for the activity of the enzyme, binds at the bottom of this cleft and an arginine residue close to the calcium, which is conserved across all pectin and pectate lyases, may be involved in catalysis...
  32. ncbi Pectate lyase from Bacillus subtilis: molecular characterization of the gene, and properties of the cloned enzyme
    W Nasser
    Laboratoire de Genetique Moleculaire des Microorganismes, URA CNRS 1486, Villeurbanne, France
    FEBS Lett 335:319-26. 1993
    ..coli periplasmic fluid after overproduction using the pT7 system. Biochemical properties of the purified enzyme were similar to those found for the PL isolated from B. subtilis extracellular media...
  33. pmc Reactivation of the Bacillus subtilis anti-sigma B antagonist, RsbV, by stress- or starvation-induced phosphatase activities
    U Voelker
    Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758, USA
    J Bacteriol 178:5456-63. 1996
    ..Both dephosphorylation reactions required at least one of the genes included in a deletion that removed rsbR, -S, and -T; however, only an environmental insult required RsbU to reactivate RsbV...
  34. pmc Bacillus subtilis possesses a second determinant with extensive sequence similarity to the Escherichia coli mreB morphogene
    Y Abhayawardhane
    Department of Microbiology and Immunology, University of South Carolina School of Medicine, Columbia 29208
    J Bacteriol 177:765-73. 1995
    ..A second site mutation, designated som-1, was mapped to the hisA-mbl region of the chromosome by transduction...
  35. pmc The glucose kinase of Bacillus subtilis
    P Skarlatos
    Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Germany
    J Bacteriol 180:3222-6. 1998
    ..77 and 0.24 mM, respectively, and a Vmax of 93 mumol min-1 mg-1. A B. subtilis strain deficient for glucose kinase grew at the same rate on different carbon sources tested, including disaccharides such as maltose, trehalose, and sucrose...
  36. ncbi Identification of yrrU as the methylthioadenosine nucleosidase gene in Bacillus subtilis
    A Sekowska
    Régulation de l Expression Génétique, Institut Pasteur, Paris, France
    DNA Res 6:255-64. 1999
    ..We showed that yrrU codes for a protein recycling methylthioadenosine, probably a nucleosidase. In addition we observed that B. subtilis can use methylthioribose as a sulfur source, and that it is an efficient sulfur scavenger...
  37. pmc The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions
    Mark Albano
    Public Health Research Institute, Newark, NJ 07103, USA
    J Bacteriol 187:2010-9. 2005
    ..We present evidence for the recent introduction of rok into the B. subtilis-Bacillus licheniformis-Bacilllus amyloliquefaciens group by horizontal transmission...
  38. ncbi A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZ
    Jay Kumar Singh
    School of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India
    Biochemistry 46:11013-22. 2007
    ..The results indicated an interesting possibility that the assembly dynamics of FtsZ in the Z-ring is regulated by the competition between positive and negative regulators sharing the same binding site on FtsZ...
  39. ncbi A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA
    Isabelle Mortier-Barrière
    Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
    Cell 130:824-36. 2007
    ..We propose that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation...
  40. pmc Bacillus subtilis SpoIIIJ and YqjG function in membrane protein biogenesis
    Manfred J Saller
    Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Kluyver Centre for the Genomics of Industrial Fermentations and the Zernike Institute of Advanced Materials, University of Groningen, 9751 NN Haren, The Netherlands
    J Bacteriol 191:6749-57. 2009
    ..These data demonstrate that the Bacillus Oxa1p homologs have a role in membrane protein biogenesis rather than in protein secretion...
  41. pmc The paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis
    Bui Khanh Chi
    Institute for Microbiology, Ernst Moritz Arndt University of Greifswald, F L Jahn Str 15, D 17487 Greifswald, Germany
    J Bacteriol 192:4571-81. 2010
    ..Redox regulation of CatR occurs independently of YodB, and no protein interaction was detected between CatR and YodB in vivo using protein cross-linking and mass spectrometry...
  42. pmc Identification of the rph (RNase PH) gene of Bacillus subtilis: evidence for suppression of cold-sensitive mutations in Escherichia coli
    M G Craven
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109 0620
    J Bacteriol 174:4727-35. 1992
    ..coli, but not the temperature-sensitive phenotype of three temperature-sensitive mutants, including the nusA11(Ts) mutant, that were tested...
  43. pmc MinCD proteins control the septation process during sporulation of Bacillus subtilis
    I Barak
    Institute of Molecular Biology, Slovak Academy of Sciences, 841 51 Bratislava, Slovak Republic
    J Bacteriol 180:5327-33. 1998
    ..We propose that the MinCD complex plays an important role in asymmetric septum formation during sporulation of B. subtilis cells...
  44. pmc NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins
    Benjamin G Bobay
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, 27695, USA
    J Biol Chem 281:21399-409. 2006
    ..The results of accompanying in vitro DNA-binding studies serve to highlight binding differences between the two proteins...
  45. ncbi Functional role for a conserved aspartate in the Spo0E signature motif involved in the dephosphorylation of the Bacillus subtilis sporulation regulator Spo0A
    Alejandra R Diaz
    Department of Molecular and Experimental Medicine, Division of Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 283:2962-72. 2008
    ..S., and Dijkstra, B. W. (1999) Biochem. J. 339, 223-226 )...
  46. ncbi PcrA is an essential DNA helicase of Bacillus subtilis fulfilling functions both in repair and rolling-circle replication
    M A Petit
    Laboratoire de Genetique Microbienne, INRA, Jouy en Josas, France
    Mol Microbiol 29:261-73. 1998
    ..Furthermore, it conferred a Rep-phenotype on E. coli. Altogether, these results show that PcrA is an helicase used for plasmid rolling-circle replication and suggest that it is also involved in UV repair...
  47. pmc DNA sequence similarity requirements for interspecific recombination in Bacillus
    J Majewski
    Department of Biology, Wesleyan University, Middletown, Connecticut 06459, USA
    Genetics 153:1525-33. 1999
    ..They also suggest a model for rapid spread of novel adaptations, such as antibiotic resistance genes, among related species...
  48. ncbi Induction of the Bacillus subtilis ptsGHI operon by glucose is controlled by a novel antiterminator, GlcT
    J Stülke
    Unité de Biochimie Microbienne, Institut Pasteur, URA 1300 du Centre National de la Recherche Scientifique, Paris, France
    Mol Microbiol 25:65-78. 1997
    ..A deletion of the terminator alleviates the need for GlcT. The activity of GlcT is negatively regulated by the glucose permease...
  49. ncbi Mass spectrometry and site-directed mutagenesis identify several autophosphorylated residues required for the activity of PrkC, a Ser/Thr kinase from Bacillus subtilis
    Edwige Madec
    Institut de Genetique et Microbiologie, Bat 409, UMR CNRS 8621, Universite Paris Sud, 91405 Orsay Cedex, France
    J Mol Biol 330:459-72. 2003
    ..This is the first structure-function analysis of a bacterial receptor-like kinase of the Hanks family...
  50. ncbi The GTP-binding protein YlqF participates in the late step of 50 S ribosomal subunit assembly in Bacillus subtilis
    Yoshitaka Matsuo
    Department of Bioinformatics and Genomics, Graduate School of Information Science, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0101, Japan
    J Biol Chem 281:8110-7. 2006
    ..Our results collectively indicate that YlqF will organize the late step of 50 S ribosomal subunit assembly...
  51. ncbi Whole-genome analysis of the chromosome partitioning and sporulation protein Spo0J (ParB) reveals spreading and origin-distal sites on the Bacillus subtilis chromosome
    Adam M Breier
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Microbiol 64:703-18. 2007
    ..Gene expression in areas near parS sites was similar in wild type and a spo0J null mutant, indicating that binding and spreading of Spo0J on DNA does not normally silence transcription of nearby genes...
  52. ncbi Sequence and properties of mecA, a negative regulator of genetic competence in Bacillus subtilis
    L Kong
    Public Health Research Institute, New York, New York 10016
    Mol Microbiol 9:365-73. 1993
    ..Expression of a mecA-lacZ translational fusion was constitutive during growth and did not vary significantly in the different media tested. The role of mecA in competence development and other stationary phase phenomena is discussed...
  53. pmc The dnaK operon of Bacillus subtilis is heptacistronic
    G Homuth
    Institute of Genetics, University of Bayreuth, Germany
    J Bacteriol 179:1153-64. 1997
    ..Blocking transcription of the suboperon from the upstream heat-inducible promoter did not impair growth and viability at high temperatures...
  54. ncbi A Bacillus subtilis gene-encoding protein homologous to eukaryotic SMC motor protein is necessary for chromosome partition
    S Moriya
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Japan
    Mol Microbiol 29:179-87. 1998
    ..These results indicate that the B. subtilis smc gene is essential for chromosome partition. The role of B. subtilis Smc protein in chromosome partition is discussed...
  55. pmc Bacillus subtilis GlcK activity requires cysteines within a motif that discriminates microbial glucokinases into two lineages
    Lili R Mesak
    Department of Microbiology, Institute for Microbiology, Biochemistry and Genetics, University of Erlangen Nuremberg, Staudstrasse 5, 91058 Erlangen, Germany
    BMC Microbiol 4:6. 2004
    ..7%) to the Escherichia coli glucokinase (Glk) (GenBank P46880) and some other glucokinases (EC 2.7.1.2), yet glucose is merely its substrate. Our lab has previously isolated and characterized the glcK gene...
  56. ncbi Metals in the sporulation phosphorelay: manganese binding by the response regulator Spo0F
    Debashis Mukhopadhyay
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Acta Crystallogr D Biol Crystallogr 60:638-45. 2004
    ..It is proposed that the existence of a deep pocket which extends from the surface to the metal site could attract and direct the metal, thereby facilitating the metal binding of the complex...
  57. pmc The Bacillus subtilis DnaD and DnaB proteins exhibit different DNA remodelling activities
    Wenke Zhang
    Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park, Nottingham NG7, 2RD, UK
    J Mol Biol 351:66-75. 2005
    ....
  58. ncbi The essential GTPase RbgA (YlqF) is required for 50S ribosome assembly in Bacillus subtilis
    William C Uicker
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, 48824, USA
    Mol Microbiol 59:528-40. 2006
    ..Based on these results we propose to rename the ylqF gene rbgA (ribosome biogenesis GTPase A)...
  59. ncbi YjbH is a novel negative effector of the disulphide stress regulator, Spx, in Bacillus subtilis
    Jonas T Larsson
    Department of Cell and Organism Biology, Lund University, Sölvegatan 35, SE 223 62 Lund, Sweden
    Mol Microbiol 66:669-84. 2007
    ..YjbH is proposed to affect the cellular concentration of Spx by modulating proteolysis via the ClpXP protease...
  60. pmc Involvement of nitrogen regulation in Bacillus subtilis degU expression
    Ayako Yasumura
    Institute of Oceanic Research and Development, Tokai University, Orido 3 20 1, Shimizu ku, Shizuoka 424 8610, Japan
    J Bacteriol 190:5162-71. 2008
    ..These results suggest that degU expression is controlled by the three promoters under different growth conditions...
  61. ncbi Functional interactions between proteins of the phosphoenolpyruvate:sugar phosphotransferase systems of Bacillus subtilis and Escherichia coli
    J Reizer
    Department of Biology, University of California at San Diego, La Jolla 92093 0116
    J Biol Chem 267:9158-69. 1992
    ..Site-specific mutations in histidyl residues 68 and 83 (H68A and H83A) inactivated IIAglc of B. subtilis with respect to phosphoryl transfer and its various regulatory roles...
  62. pmc Sequence and properties of comQ, a new competence regulatory gene of Bacillus subtilis
    Y Weinrauch
    Department of Microbiology, Public Health Research Institute, New York, New York 10016
    J Bacteriol 173:5685-93. 1991
    ..These and other results suggest a role for ComQ early in the hierarchy of competence regulatory genes, probably as a component of a signal transduction system...
  63. pmc The Bacillus subtilis SinR protein is a repressor of the key sporulation gene spo0A
    I Mandic-Mulec
    Public Health Research Institute, New York, New York 10016, USA
    J Bacteriol 177:4619-27. 1995
    ..Finally, we present evidence that SinR controls sporulation through several independent genes, i.e., sp0A, spoIIA, and possibly spoIIG and spoIIE...
  64. pmc Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilis
    J Deutscher
    Max Planck Institute for Molecular Physiology, Dortmund, Germany
    J Bacteriol 176:3336-44. 1994
    ..Enzymes that were repressed in the ptsH1 mutant were also repressed in the ccpA mutant...
  65. ncbi A family of cold shock proteins in Bacillus subtilis is essential for cellular growth and for efficient protein synthesis at optimal and low temperatures
    P Graumann
    Biochemie, Fachbereich Chemie, Philipps Universitat Marburg, Germany
    Mol Microbiol 25:741-56. 1997
    ..As CspB, CspC and CspD are shown to bind to RNA in a co-operative and interactive manner, CSPs are suggested to function as RNA chaperones facilitating the initiation of translation under optimal and low temperatures...
  66. pmc Regulation and characterization of a newly deduced cell wall hydrolase gene (cwlJ) which affects germination of Bacillus subtilis spores
    S Ishikawa
    Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, Nagano, Japan
    J Bacteriol 180:1375-80. 1998
    ..CJSB spores became slightly gray after 6 h in the germinant, but their refractility was much greater than that of sleB mutant spores. The roles of the sleB and cwlJ mutations in germination and spore maturation are also discussed...
  67. ncbi Structure of the nucleotide-diphospho-sugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed forms
    S J Charnock
    Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, UK
    Biochemistry 38:6380-5. 1999
    ..0 and 1.7 A, respectively. These complexes, together with the sequence conservation, begin to shed light on the mechanism of this ubiquitous family of inverting glycosyltransferases...
  68. pmc Analysis of the Bacillus subtilis spoIIIJ gene and its Paralogue gene, yqjG
    Takako Murakami
    International Environmental and Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
    J Bacteriol 184:1998-2004. 2002
    ..This localization of SpoIIIJ at the sporulation-specific septa may be important for the role of spoIIIJ during sporulation...
  69. pmc An expanded view of bacterial DNA replication
    Marie Francoise Noirot-Gros
    Génétique Microbienne, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France
    Proc Natl Acad Sci U S A 99:8342-7. 2002
    ..Thus, our interaction map provides a valuable tool for the discovery of aspects of bacterial DNA replication...
  70. pmc Endonucleolytic processing of CCA-less tRNA precursors by RNase Z in Bacillus subtilis
    Olivier Pellegrini
    CNRS UPR 9073, Institut de Biologie Physico Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France
    EMBO J 22:4534-43. 2003
    ..Lastly, tRNAs with long 5' extensions are poor substrates for cleavage, suggesting that for some tRNAs, processing of the 5' end by RNase P may have to precede RNase Z cleavage...
  71. pmc Transmembrane modulator-dependent bacterial tyrosine kinase activates UDP-glucose dehydrogenases
    Ivan Mijakovic
    Laboratoire de génétique des microorganismes, CNRS INRA INA PG UMR2585, 78850 Thiverval Grignon, France
    EMBO J 22:4709-18. 2003
    ..YwqE, which is encoded by the fourth gene of the B.subtilis ywqCDEF operon, also dephosphorylates P-Tyr-YwqD...
  72. ncbi Structural basis of Redox-coupled protein substrate selection by the cytochrome c biosynthesis protein ResA
    Allister Crow
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    J Biol Chem 279:23654-60. 2004
    ..Furthermore, a polar cavity, present only in the reduced state, may confer specificity to recognize apo-cytochrome c. The described features of ResA are likely to be general for bacterial cytochrome c maturation systems...
  73. pmc Genes involved in formation of structured multicellular communities by Bacillus subtilis
    Steven S Branda
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
    J Bacteriol 186:3970-9. 2004
    ..Further analysis revealed that these six genes play different roles in B. subtilis community development...
  74. pmc Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins
    David E Anderson
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Bacteriol 186:5775-81. 2004
    ..In B. subtilis, only 30 to 35% of the FtsZ protein was in the Z ring, from which we conclude that a Z ring only 2 or 3 protofilaments thick can function for cell division...
  75. ncbi Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase Z
    Ines Li de La Sierra-Gallay
    CNRS UPR 9073, Université de Paris 7 Denis Diderot, France
    Nature 433:657-61. 2005
    ..Finally, it highlights the extraordinary adaptability of the metallo-hydrolase domain of the beta-lactamase family for the hydrolysis of covalent bonds...
  76. pmc In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE
    Ivan Mijakovic
    Microbial Physiology and Genetics Group, BioCentrum, Technical University of Denmark, Lyngby, Denmark
    J Bacteriol 187:3384-90. 2005
    ..In this study, we characterize YwqE, compare the activities of the three B. subtilis PTPs (YwqE, YwlE, and YfkJ), and demonstrate that the two B. subtilis class II PTPs do not dephosphorylate the physiological substrates of YwqE...
  77. pmc The crystal structure of beryllofluoride Spo0F in complex with the phosphotransferase Spo0B represents a phosphotransfer pretransition state
    Kottayil I Varughese
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, MEM 116, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 188:4970-7. 2006
    ..In order to visualize the autophosphorylation of the histidine kinase, KinA, and the subsequent phosphoryl transfer to Spo0F, we generated in silico models representing these reaction steps...
  78. pmc Purification and characterization of extracellular soluble and membrane-bound insoluble alkaline phosphatases possessing phosphodiesterase activities in Bacillus subtilis
    K Yamane
    J Bacteriol 134:100-7. 1978
    ..Present results suggest that each enzyme is composed of a single polypeptide chain and that 6160-BC6 APase aggregates in solutions of low ionic strength...
  79. pmc Identification of Bacillus subtilis genes for septum placement and shape determination
    P A Levin
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
    J Bacteriol 174:6717-28. 1992
    ..The possible involvement of min gene products in the switch from medial to polar placement of the septum during sporulation is discussed...
  80. pmc Identification of dinR, a DNA damage-inducible regulator gene of Bacillus subtilis
    A Raymond-Denise
    Unite de Pathogenie Microbienne Moleculaire, U199 Institut National de la Santé et de la Recherche Médicale, Institut Pasteur, Paris, France
    J Bacteriol 173:7084-91. 1991
    ..In addition, DinR seems to regulate the expression of dinC, another SOS gene...
  81. pmc In vitro type II binding of chromosomal DNA to membrane in Bacillus subtilis
    Y Sato
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347
    J Bacteriol 173:7732-5. 1991
    ..We found and sequenced two adjacent areas of type II binding within 1% of oriC on the B. subtilis chromosome...
  82. pmc Nucleotide sequence and organization of dnaB gene and neighbouring genes on the Bacillus subtilis chromosome
    N Ogasawara
    Nucleic Acids Res 14:9989-99. 1986
    ..The third ORF in the same transcriptional unit would produce a hydrophobic protein which might be involved in the DNA-membrane binding function of dnaB gene. No homologous Escherichia coli genes have been found...
  83. pmc Regulation of sigma B levels and activity in Bacillus subtilis
    A K Benson
    Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758
    J Bacteriol 175:2347-56. 1993
    ..This finding is consistent with RsbW and sigma B being present within the cell in equivalent amounts, a circumstance that would permit RsbW to directly influence sigma B activity by a direct protein-protein interaction...
  84. pmc Two-component regulatory proteins ResD-ResE are required for transcriptional activation of fnr upon oxygen limitation in Bacillus subtilis
    M M Nakano
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport, Louisiana 71130 3932, USA
    J Bacteriol 178:3796-802. 1996
    ..The observed defect in anaerobic growth of a Pspac-fnr delta resDE mutant in the presence of IPTG indicated that resDE has an additional role in B. subtilis anaerobic gene regulation...
  85. pmc A compartmentalized regulator of developmental gene expression in Bacillus subtilis
    I Bagyan
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6076, USA
    J Bacteriol 178:4500-7. 1996
    ..SpoVT acts both positively and negatively in controlling sigmaG-dependent gene expression, providing an additional level of refinement to forespore gene regulation and feedback control of spoIIIG expression...
  86. ncbi A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD
    S Eder
    University of Illinois at Chicago, Laboratory for Molecular Biology 60607, USA
    Microbiology 142:2041-7. 1996
    ..The promoter was then cloned, sequenced and used in phoD-lacZ promoter fusions which showed that the gene was phosphate-starvation-induced and dependent on PhoP and PhoR for expression...
  87. ncbi Opposing pairs of serine protein kinases and phosphatases transmit signals of environmental stress to activate a bacterial transcription factor
    X Yang
    Department of Food Science and Technology, University of California, Davis 95616, USA
    Genes Dev 10:2265-75. 1996
    ..This partner-switching mechanism provides a general regulatory strategy in which linked modules sense and integrate multiple signals by protein-protein interaction...
  88. ncbi The bacillus subtilis dinR gene codes for the analogue of Escherichia coli LexA. Purification and characterization of the DinR protein
    M C Miller
    Department of Chemistry, Williams College, Williamstown, Massachusetts 01267, USA
    J Biol Chem 271:33502-8. 1996
    ..subtilis cells following exposure to mitomycin C. Thus, the DinR protein is structurally and functionally analogous to the E. coli LexA protein, and accordingly, we propose renaming the protein B. subtilis LexA...
  89. pmc Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism
    L C Christiansen
    Department of Biological Chemistry, University of Copenhagen, Denmark
    J Bacteriol 179:2540-50. 1997
    ..This result suggests the existence of different signalling pathways for repression of the transcription of the xpt-pbuX operon and the induction of xanthine dehydrogenase...
  90. ncbi Modulator protein RsbR regulates environmental signalling in the general stress pathway of Bacillus subtilis
    S Akbar
    Department of Food Science and Technology, University of California, Davis 95616, USA
    Mol Microbiol 24:567-78. 1997
    ..Our data further suggest that: (i) RsbR influences the antagonist function of RsbS by direct protein-protein interaction; and (ii) this interaction with RsbS is likely controlled by the phosphorylation state of RsbR...
  91. pmc An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport
    B R Belitsky
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Bacteriol 179:5448-57. 1997
    ..The product of the azlB gene is an Lrp-like protein that negatively regulates expression of the azlBCDEF operon. Resistance to 4-azaleucine in azlB mutants is due to overproduction of AzlC and AzlD, two novel hydrophobic proteins...
  92. ncbi KapB is a lipoprotein required for KinB signal transduction and activation of the phosphorelay to sporulation in Bacillus subtilis
    V Dartois
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Microbiol 26:1097-108. 1997
    ..Models for the role of KapB in regulating KinB activity are discussed...
  93. pmc Characterization of glucose-specific catabolite repression-resistant mutants of Bacillus subtilis: identification of a novel hexose:H+ symporter
    I T Paulsen
    Department of Biology, University of California at San Diego, La Jolla 92093 0116, USA
    J Bacteriol 180:498-504. 1998
    ..We conclude that B. subtilis possesses at least two distinct routes of glucose entry, both of which contribute to the phenomenon of catabolite repression...
  94. pmc Characterization of a prokaryotic SMC protein involved in chromosome partitioning
    R A Britton
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 12:1254-9. 1998
    ..Our results demonstrate that the B. subtilis Smc protein, like its eukaryotic counterpart, plays an important role in chromosome structure and partitioning...
  95. pmc In vitro and in vivo oxidation of methionine residues in small, acid-soluble spore proteins from Bacillus species
    C S Hayes
    Department of Biochemistry, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Bacteriol 180:2694-700. 1998
    ..This may be important in vivo since alpha/beta-type SASP containing oxidized methionine residues no longer bind DNA well and alpha/beta-type SASP-DNA binding is essential for long-term spore survival...
  96. pmc Genetic recombination in Bacillus subtilis 168: effects of recU and recS mutations on DNA repair and homologous recombination
    S Fernandez
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Bacteriol 180:3405-9. 1998
    ..We tentatively placed recS within a new group, termed "zeta"...
  97. ncbi An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complex
    R J Lewis
    Department of Chemistry, University of York, York, YO10 5DD, UK
    J Mol Biol 283:907-12. 1998
    ....
  98. ncbi The hprK gene of Enterococcus faecalis encodes a novel bifunctional enzyme: the HPr kinase/phosphatase
    M Kravanja
    Ruhr Universitat Bochum, Germany
    Mol Microbiol 31:59-66. 1999
    ..subtilis enzyme to the kinase activity. A change in activity of the B. subtilis HPr kinase was only observed when fructose-1,6-bisphosphate was also present...
  99. pmc The transcriptional profile of early to middle sporulation in Bacillus subtilis
    P Fawcett
    Millennium Pharmaceuticals, Cambridge MA, 02138 Harvard University, Department of Molecular and Cellular Biology, Cambridge, MA, 01238, USA
    Proc Natl Acad Sci U S A 97:8063-8. 2000
    ..Disruption of two such newly identified genes, yabP and yabQ, blocked sporulation at a late stage...
  100. pmc New family of regulators in the environmental signaling pathway which activates the general stress transcription factor sigma(B) of Bacillus subtilis
    S Akbar
    Department of Food Science and Technology, University of California, Davis, California 95616, USA
    J Bacteriol 183:1329-38. 2001
    ....
  101. pmc Bacillus subtilis locus encoding a killer protein and its antidote
    E Adler
    Institut de Biologie Physico Chimique, Paris, France
    J Bacteriol 183:3574-81. 2001
    ..The spoIIS locus is unique to B. subtilis, and since it is completely dispensable for sporulation its physiological role remains elusive...

Research Grants6

  1. Meeting on the Pathogenesis of Clostridia
    ABRAHAM SONENSHEIN; Fiscal Year: 2003
    ..The conference will conclude with an in-depth analysis of interactions between the pathogenic clostridia and their hosts in Session 10. ..
  2. ABRB BINDING TO DEVELOPMENTALLY CONTROLLED PROMOTERS
    Mark Strauch; Fiscal Year: 2006
    ..abstract_text> ..
  3. Mechanism and Specificity in Manganese Homeostasis
    Arthur Glasfeld; Fiscal Year: 2007
    ..That understanding may open the way to future antibiotic development. [unreadable] [unreadable] [unreadable]..
  4. Regulation of hemolysin genes in Bacillus
    Michiko Nakano; Fiscal Year: 2007
    ..subtilis. [unreadable] [unreadable] [unreadable]..
  5. Clostridium difficile Toxin Gene Regulation
    ABRAHAM LINCOLN SONENSHEIN; Fiscal Year: 2010
    ..abstract_text> ..

Patents29

  1. Enzymatic omega-oxidation and omega-amination of fatty acid
    Patent Number: JP2015509730-A; Date:2015-04-02
  2. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  3. Highly conserved genes and their use to generate probes and primers for detection of microorganisms
    Patent Number: WO0123604-A2; Date:2001-04-05
  4. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27
  5. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  6. RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES
    Patent Number: KR1020130117753-A; Date:2013-10-28
  7. Process for producing dipeptides
    Patent Number: EP1627884-A1; Date:2006-02-22
  8. Process for producing dipeptides or dipeptide derivatives
    Patent Number: EP1616963-A2; Date:2006-01-18
  9. SURFACTANT AND CLEANING COMPOSITIONS COMPRISING MICROBIALLY PRODUCED BRANCHED FATTY ALCOHOLS
    Patent Number: WO2011100667-A1; Date:2011-08-18
  10. ENZYMATIC OMEGA-OXIDATION AND OMEGA-AMINATION OF FATTY ACIDS
    Patent Number: WO2013135650-A1; Date:2013-09-19
  11. Mutated prokaryotic cells with high secretion-levels
    Patent Number: WO2005098003-A1; Date:2005-10-20
  12. Microorganisms producing dipeptides and process for producing dipeptides using the microorganisms
    Patent Number: EP1529837-A2; Date:2005-05-11
  13. Process for producing dipeptides
    Patent Number: EP1433791-A2; Date:2004-06-30
  14. PROCESS FOR THE BIOLOGICAL PRODUCTION OF CIS-5-HYDROXY-L-PIPECOLIC ACID
    Patent Number: WO2013187438-A; Date:2013-12-19
  15. NOVEL SECRETION FACTORS FOR GRAM-POSITIVE MICROORGANISMS, GENES ENCODING THEM AND METHODS OF USING IT
    Patent Number: WO9703197-A1; Date:1997-01-30
  16. Production of peracids using an enzyme having perhydrolysis activity
    Patent Number: WO2007070609-A2; Date:2007-06-21
  17. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  18. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  19. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  20. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  21. Plants with increased yield (lt)
    Patent Number: WO2010034672-A1; Date:2010-04-01
  22. Plants with increased yield by increasing or generating one or more activities in a plant or a part thereof
    Patent Number: WO2010020654-A2; Date:2010-02-25
  23. Genes and uses for plant enhancement
    Patent Number: WO2009134339-A2; Date:2009-11-05
  24. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  25. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  26. Production of peracids using an enzyme having perhydrolysis activity
    Patent Number: WO2009067279-A1; Date:2009-05-28
  27. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  28. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  29. Production of peracids using an enzyme having perhydrolysis activity
    Patent Number: WO2008073139-A1; Date:2008-06-19