Genomes and Genes
Bacillus subtilis subsp. subtilis str. 168
Alias: Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
Publications260 found, 100 shown here
- Replication initiation proteins regulate a developmental checkpoint in Bacillus subtilisW F Burkholder
Department of Biology, Massachusetts Institute of Technology, Building 68, Room 530, Cambridge, MA 02139, USA
Cell 104:269-79. 2001..Purified Sda inhibited a histidine kinase needed for activation of Spo0A. Our results indicate that control of sda by DnaA establishes a checkpoint that inhibits activation of Spo0A and prevents futile attempts to initiate sporulation...
- Ribonucleases J1 and J2: two novel endoribonucleases in B.subtilis with functional homology to E.coli RNase ESergine Even
CNRS UPR9073, IBPC 13 rue P et M Curie, 75005 Paris, France
Nucleic Acids Res 33:2141-52. 2005..RNases J1/J2 appear to be implicated in regulatory processing/maturation of specific mRNAs, such as the T-box family members thrS and thrZ, but may also contribute to global mRNA degradation...
- Processing of a sporulation sigma factor in Bacillus subtilis: how morphological structure could control gene expressionP Stragier
Institut de Microbiologie, Universite Paris Sud, Orsay, France
Cell 52:697-704. 1988..According to this model, a morphological structure would directly control the synthesis of a developmental sigma factor and would modify gene expression...
- Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilisShunji Nakano
Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
Proc Natl Acad Sci U S A 100:13603-8. 2003....
- Cannibalism by sporulating bacteriaJose E Gonzalez-Pastor
Department of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Science 301:510-3. 2003..We propose that sporulation is a stress-response pathway of last resort and that B. subtilis delays a commitment to spore formation by cannibalizing its siblings...
- Global analysis of the general stress response of Bacillus subtilisA Petersohn
Institut fur Mikrobiologie, Ernst Moritz Arndt Universitat, 17487 Greifswald, Deutsches Krebsforschungszentrum Heidelberg, 69120 Heidelberg, Germany
J Bacteriol 183:5617-31. 2001..Perhaps the most interesting of the sigma(B)-independent stress phenomena was the induction of the extracytoplasmic function sigma factor sigma(W) and its entire regulon by salt shock...
- Helicase binding to DnaI exposes a cryptic DNA-binding site during helicase loading in Bacillus subtilisCharikleia Ioannou
Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Nucleic Acids Res 34:5247-58. 2006..DnaI is sufficient to load the replicative helicase from a complex with six DnaI molecules, so there is no requirement for a dual helicase loader system...
- The MarR-type repressor MhqR (YkvE) regulates multiple dioxygenases/glyoxalases and an azoreductase which confer resistance to 2-methylhydroquinone and catechol in Bacillus subtilisStefanie Töwe
Institute for Microbiology, Ernst Moritz Arndt University of Greifswald, F L Jahn Str 15, D 17487 Greifswald, Germany
Mol Microbiol 66:40-54. 2007..Moreover, the DeltaykvE mutant displayed a 2-MHQ and catechol resistant phenotype. YkvE was renamed as MhqR controlling a 2-MHQ and catechol-resistance regulon of B. subtilis...
- Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilisMontira Leelakriangsak
Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR, USA
Mol Microbiol 67:1108-24. 2008..Thus, both azoreductases that are controlled by different regulatory mechanisms have common functions in quinone and azo-compound reduction to protect cells against the thiol reactivity of electrophiles...
- Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in B. subtilisM Perego
Dipartimento Farmaceutico, Universita degli Studi di Parma, Italy
Cell 79:1047-55. 1994..The integration of diverse environmental signals that affect the initiation of sporulation likely occurs through the competition between opposing activities of protein kinases and protein phosphatases...
- Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR)Thi Thu Huyen Nguyen
Institute for Microbiology, Ernst Moritz Arndt University of Greifswald, D 17487 Greifswald, Germany
Mol Microbiol 71:876-94. 2009..We speculate that AdhR is redox-regulated via thiol-(S)-alkylation by aldehydes and that AdhA and YraA are specifically involved in reduction of aldehydes and degradation or repair of damaged thiol-containing proteins respectively...
- Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilisHideaki Nanamiya
Cell Free Science and Technology Research Center, Ehime University, Bunkyo cho, Matsuyama 790 8577, Japan
Mol Microbiol 67:291-304. 2008..The SAS proteins thus likely function in the biosynthesis of alarmone with a mode of action distinct from that of RelA-SpoT homologues...
- Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilisWiep Klaas Smits
Groningen Biomolecular Sciences and Biotechnology Institute, Department of Genetics, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
Mol Microbiol 65:103-20. 2007..Together, these results indicate that RapH is an integral part of a multifactorial regulatory circuit affecting the cell's decision between distinct developmental pathways...
- Homologous pairs of regulatory proteins control activity of Bacillus subtilis transcription factor sigma(b) in response to environmental stressC M Kang
Department of Food Science and Technology, University of California, Davis 95616, USA
J Bacteriol 178:3846-53. 1996....
- spo0J is required for normal chromosome segregation as well as the initiation of sporulation in Bacillus subtilisK Ireton
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
J Bacteriol 176:5320-9. 1994..The dual functions of Spo0J could provide a mechanism for regulating the initiation of sporulation in response to activity of the chromosome partition machinery...
- A conserved anti-repressor controls horizontal gene transfer by proteolysisBaundauna Bose
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Microbiol 70:570-82. 2008..subtilis phage phi105 is required for inactivation of the phi105 repressor (an ImmR homologue). ImmA-dependent proteolysis of ImmR repressors may be a conserved mechanism for regulating horizontal gene transfer...
- SigmaX is involved in controlling Bacillus subtilis biofilm architecture through the AbrB homologue AbhEwan J Murray
Division of Molecular Microbiology, College of Life Sciences, MSI WTB JBC Complex, University of Dundee, Dundee DD1 5EH, United Kingdom
J Bacteriol 191:6822-32. 2009..Furthermore, Abh is shown to activate transcription from the promoter of the eps operon through its control of SlrR. These findings add to the increasingly complex transcriptional network that controls biofilm formation by B. subtilis...
- Large ring polymers align FtsZ polymers for normal septum formationMuhammet E Gündoğdu
Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle, UK
EMBO J 30:617-26. 2011..We propose that SepF rings are required for the regular arrangement of FtsZ filaments. Absence of this ordered state could explain the grossly distorted septal morphologies seen in sepF mutants...
- CtsR inactivation during thiol-specific stress in low GC, Gram+ bacteriaAlexander K W Elsholz
Institute of Microbiology, Ernst Moritz Arndt University Greifswald, F L Jahnstr 15, D 17487 Greifswald, Germany
Mol Microbiol 79:772-85. 2011..Moreover, we show that in those low GC, Gram+ bacteria, which lack the McsA/McsB complex, the Zn finger protein ClpE is able to sense and respond to oxidative stress, also resulting in CtsR inactivation...
- Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levelsM Ratnayake-Lecamwasam
Tufts University School of Medicine, Department of Molecular Biology and Microbiology, Boston, Massachusetts 02111, USA
Genes Dev 15:1093-103. 2001....
- Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus subtilisP A Levin
Department of Biology, Building 68 530, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 96:9642-7. 1999..EzrA was associated with the cell membrane and also colocalized with FtsZ to the nascent septal site. We propose that EzrA interacts either with FtsZ or with one of its binding partners to promote depolymerization...
- Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loopHédia Maamar
Public Health Research Institute, 225 Warren Street, Newark NJ 07103, USA
Mol Microbiol 56:615-24. 2005..We further address the source of the noise that results in the stochastic selection of cells that will express comK. A revised model for the regulation of comK expression is proposed that partially explains bistability...
- DnaB proteolysis in vivo regulates oligomerization and its localization at oriC in Bacillus subtilisWilliam H Grainger
Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Nucleic Acids Res 38:2851-64. 2010..It encompasses an area from the middle of dnaA to the end of yaaA that includes the AT-rich region melted during the initiation stage of DNA replication...
- Cloning, sequencing, and molecular analysis of the dnaK locus from Bacillus subtilisM Wetzstein
Lehrstuhl fur Genetik, Universitat Bayreuth, Germany
J Bacteriol 174:3300-10. 1992..The biological property of this inverted repeat as a putative key element in the induction of heat shock genes is discussed. The dnaK locus was mapped at about 223 degrees on the B. subtilis genetic map...
- The spoIIJ gene, which regulates early developmental steps in Bacillus subtilis, belongs to a class of environmentally responsive genesC Antoniewski
Institut de Microbiologie, Universite Paris Sud, Orsay, France
J Bacteriol 172:86-93. 1990..Thus, spoIIj, which is transcribed during vegetative growth, presumably under the control of sigma H, encodes a protein that could interact with major regulators of early sporulation stages, such as SpoOA and/or SpoOF...
- The sacT gene regulating the sacPA operon in Bacillus subtilis shares strong homology with transcriptional antiterminatorsM Debarbouille
Unité de Biochimie Microbienne, Centre National de la Recherche Scientifique URA1300, Institut Pasteur, Paris, France
J Bacteriol 172:3966-73. 1990..It corresponds to a Asp-96-to-Tyr missense mutation located in a highly conserved region in SacT and SacY. These results strongly suggest that sacT is a specific regulatory gene of the sacPA operon...
- Bacillus subtilis alpha-phosphoglucomutase is required for normal cell morphology and biofilm formationVladimir Lazarevic
Département de Microbiologie Fondamentale, Batiment de Biologie, Faculté de Biologie et de Médecine, Universite de Lausanne, CH 1015 Lausanne, Switzerland
Appl Environ Microbiol 71:39-45. 2005..The deficiency in biofilm formation in gtaC and gtaE mutants may be attributed to an inability to synthesize UDP-glucose, an important intermediate in a number of cell envelope biosynthetic processes...
- Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR familyMinsun Hong
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
Mol Cell 20:131-41. 2005..The structure of the OhrR-ohrA operator complex reveals the DNA binding mechanism of the entire MarR family and suggests a common inducer binding pocket...
- Circularly permuted GTPase YqeH binds 30S ribosomal subunit: Implications for its role in ribosome assemblyBaskaran Anand
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India
Biochem Biophys Res Commun 386:602-6. 2009..Further, S5, a ribosomal protein which participates during the initial stages of 30S assembly, was found to promote GTP hydrolysis and RNA binding activities of YqeH...
- Noise in gene expression determines cell fate in Bacillus subtilisHédia Maamar
Public Health Research Institute Center, New Jersey Medical School, 225 Warren Street, Newark, NJ 07103, USA
Science 317:526-9. 2007..These results illustrate how such stochastic transitions are regulated in a natural system and suggest that noise characteristics are subject to evolutionary forces...
- The structure of Bacillus subtilis pectate lyase in complex with calciumR Pickersgill
Department of Protein Engineering, Institute of Food Research, Reading, UK
Nat Struct Biol 1:717-23. 1994..Calcium, essential for the activity of the enzyme, binds at the bottom of this cleft and an arginine residue close to the calcium, which is conserved across all pectin and pectate lyases, may be involved in catalysis...
- Pectate lyase from Bacillus subtilis: molecular characterization of the gene, and properties of the cloned enzymeW Nasser
Laboratoire de Genetique Moleculaire des Microorganismes, URA CNRS 1486, Villeurbanne, France
FEBS Lett 335:319-26. 1993..coli periplasmic fluid after overproduction using the pT7 system. Biochemical properties of the purified enzyme were similar to those found for the PL isolated from B. subtilis extracellular media...
- Reactivation of the Bacillus subtilis anti-sigma B antagonist, RsbV, by stress- or starvation-induced phosphatase activitiesU Voelker
Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758, USA
J Bacteriol 178:5456-63. 1996..Both dephosphorylation reactions required at least one of the genes included in a deletion that removed rsbR, -S, and -T; however, only an environmental insult required RsbU to reactivate RsbV...
- Bacillus subtilis possesses a second determinant with extensive sequence similarity to the Escherichia coli mreB morphogeneY Abhayawardhane
Department of Microbiology and Immunology, University of South Carolina School of Medicine, Columbia 29208
J Bacteriol 177:765-73. 1995..A second site mutation, designated som-1, was mapped to the hisA-mbl region of the chromosome by transduction...
- The glucose kinase of Bacillus subtilisP Skarlatos
Lehrstuhl fur Mikrobiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Germany
J Bacteriol 180:3222-6. 1998..77 and 0.24 mM, respectively, and a Vmax of 93 mumol min-1 mg-1. A B. subtilis strain deficient for glucose kinase grew at the same rate on different carbon sources tested, including disaccharides such as maltose, trehalose, and sucrose...
- Identification of yrrU as the methylthioadenosine nucleosidase gene in Bacillus subtilisA Sekowska
Régulation de l Expression Génétique, Institut Pasteur, Paris, France
DNA Res 6:255-64. 1999..We showed that yrrU codes for a protein recycling methylthioadenosine, probably a nucleosidase. In addition we observed that B. subtilis can use methylthioribose as a sulfur source, and that it is an efficient sulfur scavenger...
- The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functionsMark Albano
Public Health Research Institute, Newark, NJ 07103, USA
J Bacteriol 187:2010-9. 2005..We present evidence for the recent introduction of rok into the B. subtilis-Bacillus licheniformis-Bacilllus amyloliquefaciens group by horizontal transmission...
- A membrane protein, EzrA, regulates assembly dynamics of FtsZ by interacting with the C-terminal tail of FtsZJay Kumar Singh
School of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India
Biochemistry 46:11013-22. 2007..The results indicated an interesting possibility that the assembly dynamics of FtsZ in the Z-ring is regulated by the competition between positive and negative regulators sharing the same binding site on FtsZ...
- A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecAIsabelle Mortier-Barrière
Laboratoire de Microbiologie et Genetique Moleculaires, UMR 5100 CNRS Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
Cell 130:824-36. 2007..We propose that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation...
- Bacillus subtilis SpoIIIJ and YqjG function in membrane protein biogenesisManfred J Saller
Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Kluyver Centre for the Genomics of Industrial Fermentations and the Zernike Institute of Advanced Materials, University of Groningen, 9751 NN Haren, The Netherlands
J Bacteriol 191:6749-57. 2009..These data demonstrate that the Bacillus Oxa1p homologs have a role in membrane protein biogenesis rather than in protein secretion...
- The paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilisBui Khanh Chi
Institute for Microbiology, Ernst Moritz Arndt University of Greifswald, F L Jahn Str 15, D 17487 Greifswald, Germany
J Bacteriol 192:4571-81. 2010..Redox regulation of CatR occurs independently of YodB, and no protein interaction was detected between CatR and YodB in vivo using protein cross-linking and mass spectrometry...
- Identification of the rph (RNase PH) gene of Bacillus subtilis: evidence for suppression of cold-sensitive mutations in Escherichia coliM G Craven
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109 0620
J Bacteriol 174:4727-35. 1992..coli, but not the temperature-sensitive phenotype of three temperature-sensitive mutants, including the nusA11(Ts) mutant, that were tested...
- MinCD proteins control the septation process during sporulation of Bacillus subtilisI Barak
Institute of Molecular Biology, Slovak Academy of Sciences, 841 51 Bratislava, Slovak Republic
J Bacteriol 180:5327-33. 1998..We propose that the MinCD complex plays an important role in asymmetric septum formation during sporulation of B. subtilis cells...
- NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteinsBenjamin G Bobay
Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, 27695, USA
J Biol Chem 281:21399-409. 2006..The results of accompanying in vitro DNA-binding studies serve to highlight binding differences between the two proteins...
- Functional role for a conserved aspartate in the Spo0E signature motif involved in the dephosphorylation of the Bacillus subtilis sporulation regulator Spo0AAlejandra R Diaz
Department of Molecular and Experimental Medicine, Division of Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Biol Chem 283:2962-72. 2008..S., and Dijkstra, B. W. (1999) Biochem. J. 339, 223-226 )...
- PcrA is an essential DNA helicase of Bacillus subtilis fulfilling functions both in repair and rolling-circle replicationM A Petit
Laboratoire de Genetique Microbienne, INRA, Jouy en Josas, France
Mol Microbiol 29:261-73. 1998..Furthermore, it conferred a Rep-phenotype on E. coli. Altogether, these results show that PcrA is an helicase used for plasmid rolling-circle replication and suggest that it is also involved in UV repair...
- DNA sequence similarity requirements for interspecific recombination in BacillusJ Majewski
Department of Biology, Wesleyan University, Middletown, Connecticut 06459, USA
Genetics 153:1525-33. 1999..They also suggest a model for rapid spread of novel adaptations, such as antibiotic resistance genes, among related species...
- Induction of the Bacillus subtilis ptsGHI operon by glucose is controlled by a novel antiterminator, GlcTJ Stülke
Unité de Biochimie Microbienne, Institut Pasteur, URA 1300 du Centre National de la Recherche Scientifique, Paris, France
Mol Microbiol 25:65-78. 1997..A deletion of the terminator alleviates the need for GlcT. The activity of GlcT is negatively regulated by the glucose permease...
- Mass spectrometry and site-directed mutagenesis identify several autophosphorylated residues required for the activity of PrkC, a Ser/Thr kinase from Bacillus subtilisEdwige Madec
Institut de Genetique et Microbiologie, Bat 409, UMR CNRS 8621, Universite Paris Sud, 91405 Orsay Cedex, France
J Mol Biol 330:459-72. 2003..This is the first structure-function analysis of a bacterial receptor-like kinase of the Hanks family...
- The GTP-binding protein YlqF participates in the late step of 50 S ribosomal subunit assembly in Bacillus subtilisYoshitaka Matsuo
Department of Bioinformatics and Genomics, Graduate School of Information Science, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0101, Japan
J Biol Chem 281:8110-7. 2006..Our results collectively indicate that YlqF will organize the late step of 50 S ribosomal subunit assembly...
- Whole-genome analysis of the chromosome partitioning and sporulation protein Spo0J (ParB) reveals spreading and origin-distal sites on the Bacillus subtilis chromosomeAdam M Breier
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Microbiol 64:703-18. 2007..Gene expression in areas near parS sites was similar in wild type and a spo0J null mutant, indicating that binding and spreading of Spo0J on DNA does not normally silence transcription of nearby genes...
- Sequence and properties of mecA, a negative regulator of genetic competence in Bacillus subtilisL Kong
Public Health Research Institute, New York, New York 10016
Mol Microbiol 9:365-73. 1993..Expression of a mecA-lacZ translational fusion was constitutive during growth and did not vary significantly in the different media tested. The role of mecA in competence development and other stationary phase phenomena is discussed...
- The dnaK operon of Bacillus subtilis is heptacistronicG Homuth
Institute of Genetics, University of Bayreuth, Germany
J Bacteriol 179:1153-64. 1997..Blocking transcription of the suboperon from the upstream heat-inducible promoter did not impair growth and viability at high temperatures...
- A Bacillus subtilis gene-encoding protein homologous to eukaryotic SMC motor protein is necessary for chromosome partitionS Moriya
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Japan
Mol Microbiol 29:179-87. 1998..These results indicate that the B. subtilis smc gene is essential for chromosome partition. The role of B. subtilis Smc protein in chromosome partition is discussed...
- Bacillus subtilis GlcK activity requires cysteines within a motif that discriminates microbial glucokinases into two lineagesLili R Mesak
Department of Microbiology, Institute for Microbiology, Biochemistry and Genetics, University of Erlangen Nuremberg, Staudstrasse 5, 91058 Erlangen, Germany
BMC Microbiol 4:6. 2004..7%) to the Escherichia coli glucokinase (Glk) (GenBank P46880) and some other glucokinases (EC 220.127.116.11), yet glucose is merely its substrate. Our lab has previously isolated and characterized the glcK gene...
- Metals in the sporulation phosphorelay: manganese binding by the response regulator Spo0FDebashis Mukhopadhyay
Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Acta Crystallogr D Biol Crystallogr 60:638-45. 2004..It is proposed that the existence of a deep pocket which extends from the surface to the metal site could attract and direct the metal, thereby facilitating the metal binding of the complex...
- The Bacillus subtilis DnaD and DnaB proteins exhibit different DNA remodelling activitiesWenke Zhang
Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park, Nottingham NG7, 2RD, UK
J Mol Biol 351:66-75. 2005....
- The essential GTPase RbgA (YlqF) is required for 50S ribosome assembly in Bacillus subtilisWilliam C Uicker
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, 48824, USA
Mol Microbiol 59:528-40. 2006..Based on these results we propose to rename the ylqF gene rbgA (ribosome biogenesis GTPase A)...
- YjbH is a novel negative effector of the disulphide stress regulator, Spx, in Bacillus subtilisJonas T Larsson
Department of Cell and Organism Biology, Lund University, Sölvegatan 35, SE 223 62 Lund, Sweden
Mol Microbiol 66:669-84. 2007..YjbH is proposed to affect the cellular concentration of Spx by modulating proteolysis via the ClpXP protease...
- Involvement of nitrogen regulation in Bacillus subtilis degU expressionAyako Yasumura
Institute of Oceanic Research and Development, Tokai University, Orido 3 20 1, Shimizu ku, Shizuoka 424 8610, Japan
J Bacteriol 190:5162-71. 2008..These results suggest that degU expression is controlled by the three promoters under different growth conditions...
- Functional interactions between proteins of the phosphoenolpyruvate:sugar phosphotransferase systems of Bacillus subtilis and Escherichia coliJ Reizer
Department of Biology, University of California at San Diego, La Jolla 92093 0116
J Biol Chem 267:9158-69. 1992..Site-specific mutations in histidyl residues 68 and 83 (H68A and H83A) inactivated IIAglc of B. subtilis with respect to phosphoryl transfer and its various regulatory roles...
- Sequence and properties of comQ, a new competence regulatory gene of Bacillus subtilisY Weinrauch
Department of Microbiology, Public Health Research Institute, New York, New York 10016
J Bacteriol 173:5685-93. 1991..These and other results suggest a role for ComQ early in the hierarchy of competence regulatory genes, probably as a component of a signal transduction system...
- The Bacillus subtilis SinR protein is a repressor of the key sporulation gene spo0AI Mandic-Mulec
Public Health Research Institute, New York, New York 10016, USA
J Bacteriol 177:4619-27. 1995..Finally, we present evidence that SinR controls sporulation through several independent genes, i.e., sp0A, spoIIA, and possibly spoIIG and spoIIE...
- Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilisJ Deutscher
Max Planck Institute for Molecular Physiology, Dortmund, Germany
J Bacteriol 176:3336-44. 1994..Enzymes that were repressed in the ptsH1 mutant were also repressed in the ccpA mutant...
- A family of cold shock proteins in Bacillus subtilis is essential for cellular growth and for efficient protein synthesis at optimal and low temperaturesP Graumann
Biochemie, Fachbereich Chemie, Philipps Universitat Marburg, Germany
Mol Microbiol 25:741-56. 1997..As CspB, CspC and CspD are shown to bind to RNA in a co-operative and interactive manner, CSPs are suggested to function as RNA chaperones facilitating the initiation of translation under optimal and low temperatures...
- Regulation and characterization of a newly deduced cell wall hydrolase gene (cwlJ) which affects germination of Bacillus subtilis sporesS Ishikawa
Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, Nagano, Japan
J Bacteriol 180:1375-80. 1998..CJSB spores became slightly gray after 6 h in the germinant, but their refractility was much greater than that of sleB mutant spores. The roles of the sleB and cwlJ mutations in germination and spore maturation are also discussed...
- Structure of the nucleotide-diphospho-sugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed formsS J Charnock
Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, UK
Biochemistry 38:6380-5. 1999..0 and 1.7 A, respectively. These complexes, together with the sequence conservation, begin to shed light on the mechanism of this ubiquitous family of inverting glycosyltransferases...
- Analysis of the Bacillus subtilis spoIIIJ gene and its Paralogue gene, yqjGTakako Murakami
International Environmental and Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183 8509, Japan
J Bacteriol 184:1998-2004. 2002..This localization of SpoIIIJ at the sporulation-specific septa may be important for the role of spoIIIJ during sporulation...
- An expanded view of bacterial DNA replicationMarie Francoise Noirot-Gros
Génétique Microbienne, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France
Proc Natl Acad Sci U S A 99:8342-7. 2002..Thus, our interaction map provides a valuable tool for the discovery of aspects of bacterial DNA replication...
- Endonucleolytic processing of CCA-less tRNA precursors by RNase Z in Bacillus subtilisOlivier Pellegrini
CNRS UPR 9073, Institut de Biologie Physico Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France
EMBO J 22:4534-43. 2003..Lastly, tRNAs with long 5' extensions are poor substrates for cleavage, suggesting that for some tRNAs, processing of the 5' end by RNase P may have to precede RNase Z cleavage...
- Transmembrane modulator-dependent bacterial tyrosine kinase activates UDP-glucose dehydrogenasesIvan Mijakovic
Laboratoire de génétique des microorganismes, CNRS INRA INA PG UMR2585, 78850 Thiverval Grignon, France
EMBO J 22:4709-18. 2003..YwqE, which is encoded by the fourth gene of the B.subtilis ywqCDEF operon, also dephosphorylates P-Tyr-YwqD...
- Structural basis of Redox-coupled protein substrate selection by the cytochrome c biosynthesis protein ResAAllister Crow
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
J Biol Chem 279:23654-60. 2004..Furthermore, a polar cavity, present only in the reduced state, may confer specificity to recognize apo-cytochrome c. The described features of ResA are likely to be general for bacterial cytochrome c maturation systems...
- Genes involved in formation of structured multicellular communities by Bacillus subtilisSteven S Branda
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
J Bacteriol 186:3970-9. 2004..Further analysis revealed that these six genes play different roles in B. subtilis community development...
- Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteinsDavid E Anderson
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Bacteriol 186:5775-81. 2004..In B. subtilis, only 30 to 35% of the FtsZ protein was in the Z ring, from which we conclude that a Z ring only 2 or 3 protofilaments thick can function for cell division...
- Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase ZInes Li de La Sierra-Gallay
CNRS UPR 9073, Université de Paris 7 Denis Diderot, France
Nature 433:657-61. 2005..Finally, it highlights the extraordinary adaptability of the metallo-hydrolase domain of the beta-lactamase family for the hydrolysis of covalent bonds...
- In vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqEIvan Mijakovic
Microbial Physiology and Genetics Group, BioCentrum, Technical University of Denmark, Lyngby, Denmark
J Bacteriol 187:3384-90. 2005..In this study, we characterize YwqE, compare the activities of the three B. subtilis PTPs (YwqE, YwlE, and YfkJ), and demonstrate that the two B. subtilis class II PTPs do not dephosphorylate the physiological substrates of YwqE...
- The crystal structure of beryllofluoride Spo0F in complex with the phosphotransferase Spo0B represents a phosphotransfer pretransition stateKottayil I Varughese
Division of Cellular Biology, Department of Molecular and Experimental Medicine, MEM 116, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Bacteriol 188:4970-7. 2006..In order to visualize the autophosphorylation of the histidine kinase, KinA, and the subsequent phosphoryl transfer to Spo0F, we generated in silico models representing these reaction steps...
- Purification and characterization of extracellular soluble and membrane-bound insoluble alkaline phosphatases possessing phosphodiesterase activities in Bacillus subtilisK Yamane
J Bacteriol 134:100-7. 1978..Present results suggest that each enzyme is composed of a single polypeptide chain and that 6160-BC6 APase aggregates in solutions of low ionic strength...
- Identification of Bacillus subtilis genes for septum placement and shape determinationP A Levin
Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
J Bacteriol 174:6717-28. 1992..The possible involvement of min gene products in the switch from medial to polar placement of the septum during sporulation is discussed...
- Identification of dinR, a DNA damage-inducible regulator gene of Bacillus subtilisA Raymond-Denise
Unite de Pathogenie Microbienne Moleculaire, U199 Institut National de la Santé et de la Recherche Médicale, Institut Pasteur, Paris, France
J Bacteriol 173:7084-91. 1991..In addition, DinR seems to regulate the expression of dinC, another SOS gene...
- In vitro type II binding of chromosomal DNA to membrane in Bacillus subtilisY Sato
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347
J Bacteriol 173:7732-5. 1991..We found and sequenced two adjacent areas of type II binding within 1% of oriC on the B. subtilis chromosome...
- Nucleotide sequence and organization of dnaB gene and neighbouring genes on the Bacillus subtilis chromosomeN Ogasawara
Nucleic Acids Res 14:9989-99. 1986..The third ORF in the same transcriptional unit would produce a hydrophobic protein which might be involved in the DNA-membrane binding function of dnaB gene. No homologous Escherichia coli genes have been found...
- Regulation of sigma B levels and activity in Bacillus subtilisA K Benson
Department of Microbiology, University of Texas Health Science Center, San Antonio 78284 7758
J Bacteriol 175:2347-56. 1993..This finding is consistent with RsbW and sigma B being present within the cell in equivalent amounts, a circumstance that would permit RsbW to directly influence sigma B activity by a direct protein-protein interaction...
- Two-component regulatory proteins ResD-ResE are required for transcriptional activation of fnr upon oxygen limitation in Bacillus subtilisM M Nakano
Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport, Louisiana 71130 3932, USA
J Bacteriol 178:3796-802. 1996..The observed defect in anaerobic growth of a Pspac-fnr delta resDE mutant in the presence of IPTG indicated that resDE has an additional role in B. subtilis anaerobic gene regulation...
- A compartmentalized regulator of developmental gene expression in Bacillus subtilisI Bagyan
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6076, USA
J Bacteriol 178:4500-7. 1996..SpoVT acts both positively and negatively in controlling sigmaG-dependent gene expression, providing an additional level of refinement to forespore gene regulation and feedback control of spoIIIG expression...
- A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoDS Eder
University of Illinois at Chicago, Laboratory for Molecular Biology 60607, USA
Microbiology 142:2041-7. 1996..The promoter was then cloned, sequenced and used in phoD-lacZ promoter fusions which showed that the gene was phosphate-starvation-induced and dependent on PhoP and PhoR for expression...
- Opposing pairs of serine protein kinases and phosphatases transmit signals of environmental stress to activate a bacterial transcription factorX Yang
Department of Food Science and Technology, University of California, Davis 95616, USA
Genes Dev 10:2265-75. 1996..This partner-switching mechanism provides a general regulatory strategy in which linked modules sense and integrate multiple signals by protein-protein interaction...
- The bacillus subtilis dinR gene codes for the analogue of Escherichia coli LexA. Purification and characterization of the DinR proteinM C Miller
Department of Chemistry, Williams College, Williamstown, Massachusetts 01267, USA
J Biol Chem 271:33502-8. 1996..subtilis cells following exposure to mitomycin C. Thus, the DinR protein is structurally and functionally analogous to the E. coli LexA protein, and accordingly, we propose renaming the protein B. subtilis LexA...
- Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolismL C Christiansen
Department of Biological Chemistry, University of Copenhagen, Denmark
J Bacteriol 179:2540-50. 1997..This result suggests the existence of different signalling pathways for repression of the transcription of the xpt-pbuX operon and the induction of xanthine dehydrogenase...
- Modulator protein RsbR regulates environmental signalling in the general stress pathway of Bacillus subtilisS Akbar
Department of Food Science and Technology, University of California, Davis 95616, USA
Mol Microbiol 24:567-78. 1997..Our data further suggest that: (i) RsbR influences the antagonist function of RsbS by direct protein-protein interaction; and (ii) this interaction with RsbS is likely controlled by the phosphorylation state of RsbR...
- An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transportB R Belitsky
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Bacteriol 179:5448-57. 1997..The product of the azlB gene is an Lrp-like protein that negatively regulates expression of the azlBCDEF operon. Resistance to 4-azaleucine in azlB mutants is due to overproduction of AzlC and AzlD, two novel hydrophobic proteins...
- KapB is a lipoprotein required for KinB signal transduction and activation of the phosphorelay to sporulation in Bacillus subtilisV Dartois
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Mol Microbiol 26:1097-108. 1997..Models for the role of KapB in regulating KinB activity are discussed...
- Characterization of glucose-specific catabolite repression-resistant mutants of Bacillus subtilis: identification of a novel hexose:H+ symporterI T Paulsen
Department of Biology, University of California at San Diego, La Jolla 92093 0116, USA
J Bacteriol 180:498-504. 1998..We conclude that B. subtilis possesses at least two distinct routes of glucose entry, both of which contribute to the phenomenon of catabolite repression...
- Characterization of a prokaryotic SMC protein involved in chromosome partitioningR A Britton
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Genes Dev 12:1254-9. 1998..Our results demonstrate that the B. subtilis Smc protein, like its eukaryotic counterpart, plays an important role in chromosome structure and partitioning...
- In vitro and in vivo oxidation of methionine residues in small, acid-soluble spore proteins from Bacillus speciesC S Hayes
Department of Biochemistry, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Bacteriol 180:2694-700. 1998..This may be important in vivo since alpha/beta-type SASP containing oxidized methionine residues no longer bind DNA well and alpha/beta-type SASP-DNA binding is essential for long-term spore survival...
- Genetic recombination in Bacillus subtilis 168: effects of recU and recS mutations on DNA repair and homologous recombinationS Fernandez
Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
J Bacteriol 180:3405-9. 1998..We tentatively placed recS within a new group, termed "zeta"...
- An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complexR J Lewis
Department of Chemistry, University of York, York, YO10 5DD, UK
J Mol Biol 283:907-12. 1998....
- The hprK gene of Enterococcus faecalis encodes a novel bifunctional enzyme: the HPr kinase/phosphataseM Kravanja
Ruhr Universitat Bochum, Germany
Mol Microbiol 31:59-66. 1999..subtilis enzyme to the kinase activity. A change in activity of the B. subtilis HPr kinase was only observed when fructose-1,6-bisphosphate was also present...
- The transcriptional profile of early to middle sporulation in Bacillus subtilisP Fawcett
Millennium Pharmaceuticals, Cambridge MA, 02138 Harvard University, Department of Molecular and Cellular Biology, Cambridge, MA, 01238, USA
Proc Natl Acad Sci U S A 97:8063-8. 2000..Disruption of two such newly identified genes, yabP and yabQ, blocked sporulation at a late stage...
- New family of regulators in the environmental signaling pathway which activates the general stress transcription factor sigma(B) of Bacillus subtilisS Akbar
Department of Food Science and Technology, University of California, Davis, California 95616, USA
J Bacteriol 183:1329-38. 2001....
- Bacillus subtilis locus encoding a killer protein and its antidoteE Adler
Institut de Biologie Physico Chimique, Paris, France
J Bacteriol 183:3574-81. 2001..The spoIIS locus is unique to B. subtilis, and since it is completely dispensable for sporulation its physiological role remains elusive...
- Meeting on the Pathogenesis of ClostridiaABRAHAM SONENSHEIN; Fiscal Year: 2003..The conference will conclude with an in-depth analysis of interactions between the pathogenic clostridia and their hosts in Session 10. ..
- ABRB BINDING TO DEVELOPMENTALLY CONTROLLED PROMOTERSMark Strauch; Fiscal Year: 2006..abstract_text> ..
- Mechanism and Specificity in Manganese HomeostasisArthur Glasfeld; Fiscal Year: 2007..That understanding may open the way to future antibiotic development. [unreadable] [unreadable] [unreadable]..
- Regulation of hemolysin genes in BacillusMichiko Nakano; Fiscal Year: 2007..subtilis. [unreadable] [unreadable] [unreadable]..
- Clostridium difficile Toxin Gene RegulationABRAHAM LINCOLN SONENSHEIN; Fiscal Year: 2010..abstract_text> ..
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