Bacillus anthracis str. 'Ames Ancestor'

Summary

Alias: Bacillus anthracis Ames "Ancestor", Bacillus anthracis str. Ames 0581, Bacillus anthracis str. Ames Ancestor, Bacillus anthracis strain 'Ames Ancestor'

Top Publications

  1. ncbi Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
    N S Duesbery
    Advanced BioScience Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702
    Science 280:734-7. 1998
  2. ncbi Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
    G Vitale
    Dipartimento di Scienze Biomediche, Universita di Padova, Italy
    Biochem Biophys Res Commun 248:706-11. 1998
  3. ncbi Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization
    K E Beauregard
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell Microbiol 2:251-8. 2000
  4. pmc Vector-mediated selective expression of lethal factor, a toxic element of Bacillus anthracis, damages A549 cells via inhibition of MAPK and AKT pathways
    Wenlei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Int J Med Sci 10:292-8. 2013
  5. pmc Purification, crystallization and preliminary structural analysis of nucleoside diphosphate kinase from Bacillus anthracis
    Gauri Misra
    Molecular and Structural Biology Division, Central Drug Research Institute, PO Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow 226 001, India
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:1084-6. 2007
  6. ncbi Preparation of a positive control DNA for molecular diagnosis of Bacillus anthracis
    Satoshi Inoue
    Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Jpn J Infect Dis 57:29-32. 2004
  7. ncbi Identification and characterization of a novel toxin-antitoxin module from Bacillus anthracis
    Shivangi Agarwal
    School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India
    FEBS Lett 581:1727-34. 2007
  8. pmc Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin
    Aaron M Firoved
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, 30 Convent Dr, Building 30, Room 303, Bethesda, MD 20892 4349, USA
    Infect Immun 75:2120-5. 2007
  9. ncbi Insertion of anthrax protective antigen into liposomal membranes: effects of a receptor
    Jianjun Sun
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:1059-65. 2007
  10. ncbi Identification and characterization of a germination operon from Bacillus thuringiensis
    Yuling Gai
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Science, Beijing, 100080, P R China
    Antonie Van Leeuwenhoek 89:251-9. 2006

Patents

  1. Plants with increased yield
  2. Process for the production of a fine chemical
  3. Process for the production of lutein
  4. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
  5. Process for the production of fine chemicals
  6. Process for the control of production of fine chemicals
  7. Proteins associated with abiotic stress response and homologs
  8. ANTIMICROBIAL AGENTS
  9. Proteins associated with abiotic stress response and homologs
  10. Process for the production of a fine chemical

Scientific Experts

Detail Information

Publications63

  1. ncbi Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
    N S Duesbery
    Advanced BioScience Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702
    Science 280:734-7. 1998
    ..The identification of a cleavage site for LF may facilitate the development of LF inhibitors...
  2. ncbi Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
    G Vitale
    Dipartimento di Scienze Biomediche, Universita di Padova, Italy
    Biochem Biophys Res Commun 248:706-11. 1998
    ..The possible implications of these findings for the cytolysis of macrophage cells induced by LF are discussed. These results open the way to the design and screening of specific inhibitors of LF...
  3. ncbi Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalization
    K E Beauregard
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell Microbiol 2:251-8. 2000
    ..The relatively long period of activation and internalization of PA at the cell surface may reflect adaptation of this binary toxin that maximizes self-assembly...
  4. pmc Vector-mediated selective expression of lethal factor, a toxic element of Bacillus anthracis, damages A549 cells via inhibition of MAPK and AKT pathways
    Wenlei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Int J Med Sci 10:292-8. 2013
    ..The results also revealed that the inhibition of mitogen-activated protein kinase and AKT pathways was partially involved in the process. Thus, hTERTp-regulated LF increase could be a promising approach in lung cancer-targeted therapy...
  5. pmc Purification, crystallization and preliminary structural analysis of nucleoside diphosphate kinase from Bacillus anthracis
    Gauri Misra
    Molecular and Structural Biology Division, Central Drug Research Institute, PO Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow 226 001, India
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:1084-6. 2007
    ..3 A. The crystals are hexagonal in shape and belong to space group P6(3)22. The crystals contain a monomer in the asymmetric unit, which corresponds to a Matthews coefficient (V(M)) of 2.1 A(3) Da(-1) and a solvent content of about 36.9%...
  6. ncbi Preparation of a positive control DNA for molecular diagnosis of Bacillus anthracis
    Satoshi Inoue
    Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    Jpn J Infect Dis 57:29-32. 2004
    ..It also allows the detection of possible cross contamination, indicating that this strategy would be useful and convenient for the molecular identification of not only B. anthracis but also other highly pathogenic microbes...
  7. ncbi Identification and characterization of a novel toxin-antitoxin module from Bacillus anthracis
    Shivangi Agarwal
    School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India
    FEBS Lett 581:1727-34. 2007
    ..Gel retardation assays demonstrated that PemI binds to its upstream DNA sequence. This study reports the first evidence of an active chromosome encoded toxin-antitoxin locus in B. anthracis...
  8. pmc Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin
    Aaron M Firoved
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, 30 Convent Dr, Building 30, Room 303, Bethesda, MD 20892 4349, USA
    Infect Immun 75:2120-5. 2007
    ..g., 15 microg) given to male and female DBA/2J mice 18 h prior to LT challenge also sensitize them to LT. This study using highly purified ET and LT demonstrates how the components of anthrax toxin can work together to increase lethality...
  9. ncbi Insertion of anthrax protective antigen into liposomal membranes: effects of a receptor
    Jianjun Sun
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:1059-65. 2007
    ....
  10. ncbi Identification and characterization of a germination operon from Bacillus thuringiensis
    Yuling Gai
    State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Science, Beijing, 100080, P R China
    Antonie Van Leeuwenhoek 89:251-9. 2006
    ..These results suggest this operon is essential for normal spore germination in B. thuringiensis. The expression of cwlJ was observed in the sporulating cells through Western blot experiments...
  11. pmc A Bacillus thuringiensis S-layer protein involved in toxicity against Epilachna varivestis (Coleoptera: Coccinellidae)
    Guadalupe Peña
    Instituto de Biotecnologia, UNAM, Ap Postal 510 3, Cuernavaca 62250, Morelos, Mexico
    Appl Environ Microbiol 72:353-60. 2006
    ..anthracis, B. licheniformis, and B. thuringiensis are arranged in the same main group, suggesting similar origins. This is the first report that demonstrates that an S-layer protein is directly involved in toxicity to a coleopteran pest...
  12. ncbi Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain
    David G Waterman
    York Structural Biology Laboratory, University of York, Chemistry Department, York YO10 5YW, UK
    J Mol Biol 356:97-110. 2006
    ..The inaccessibility of U8 in the canonical L-shaped form of tRNA, and the existence of a glycine-rich linker joining the catalytic and RNA-binding moieties of ThiI suggest that structural changes may occur in both molecules upon binding...
  13. ncbi The DNA-binding specificity of the Bacillus anthracis AbrB protein
    Mark A Strauch
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Microbiology 151:1751-9. 2005
    ..In B. subtilis cells, the B. anthracis promoters from the atxA and abrB genes were regulated by AbrB(BS), and the B. subtilis promoter from the yxbB operon was regulated by AbrB(BA)...
  14. pmc Anthrax lethal factor inhibition
    W L Shoop
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 102:7958-63. 2005
    ..These results indicate that a small molecule, hydroxamate LF inhibitor, as revealed herein, can ameliorate the toxemia characteristic of an active B. anthracis infection and could be a vital adjunct to our ability to combat anthrax...
  15. ncbi High-level expression and characterization of two chitinases, ChiCH and ChiCW, of Bacillus cereus 28-9 in Escherichia coli
    Chien Jui Huang
    Department of Plant Pathology and Microbiology, National Taiwan University, Taipei 106, Taiwan
    Biochem Biophys Res Commun 327:8-17. 2005
    ..Therefore, the method of high-level expression of chitinases is helpful to studies and applications of chitinases...
  16. pmc Distinct mutations in PlcR explain why some strains of the Bacillus cereus group are nonhemolytic
    Leyla Slamti
    Groupe Génétique et Physiologie des Bacillus pathogènes, Institut Pasteur, 75015 Paris, France
    J Bacteriol 186:3531-8. 2004
    ..We also found that the plcR genes of three B. anthracis strains belonging to different phylogenetic groups contained the same nonsense mutation, suggesting that this mutation is a distinctive trait of this species...
  17. pmc Characterization of a major Bacillus anthracis spore coat protein and its role in spore inactivation
    Ho San Kim
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Bacteriol 186:2413-7. 2004
    ..Since Cot alpha is an abundant outer spore coat protein of the B. cereus group with a prominent role in spore resistance and sensitivity, it is a promising target for the inactivation of B. anthracis spores...
  18. pmc Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
    Yuequan Shen
    Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    EMBO J 21:6721-32. 2002
    ..However, CyaA is fully activated by CaM without the domain corresponding to the helical domain of EF...
  19. pmc The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracis
    Carleitta Paige
    Center for Structural Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Bacteriol 190:6271-5. 2008
    ..We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanK(Ba) is an essential enzyme, thus contributing to its validation as a new antimicrobial target...
  20. pmc Dual promoters control expression of the Bacillus anthracis virulence factor AtxA
    Cristina Bongiorni
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 190:6483-92. 2008
    ..The dual promoter activity and the extended untranslated mRNA suggest that as-yet-unknown regulatory mechanisms may act on this region to influence the level of AtxA in the cell...
  21. doi Structural studies of shikimate dehydrogenase from Bacillus anthracis complexed with cofactor NADP
    Guy Barros Barcellos
    Faculdade de Biociencias, Laboratório de Bioquímica Estrutural, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Mol Model 15:147-55. 2009
    ..This study was able to identify the main residues of the NADP binding site responsible for ligand affinities. This structural study can be used in the design of more specific drugs against infectious diseases...
  22. pmc Bacillus anthracis edema toxin suppresses human macrophage phagocytosis and cytoskeletal remodeling via the protein kinase A and exchange protein activated by cyclic AMP pathways
    Linsey A Yeager
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 0610, USA
    Infect Immun 77:2530-43. 2009
    ..These results suggested that EdTx weakened the host immune response by increasing cAMP levels, which then signaled via PKA and Epac to cripple MPhi phagocytosis and interfered with cytoskeletal remodeling...
  23. pmc Anthrax lethal toxin impairs IL-8 expression in epithelial cells through inhibition of histone H3 modification
    Benoit Raymond
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    PLoS Pathog 5:e1000359. 2009
    ..This epigenetic reprogramming, in addition to previously reported effects of LT, may represent an efficient strategy used by B. anthracis for invading the host...
  24. pmc Mechanisms of DNA binding and regulation of Bacillus anthracis DNA primase
    Subhasis B Biswas
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
    Biochemistry 48:7373-82. 2009
    ..anthracis and E. coli; however, between DnaB proteins derived from these two organisms, only the homologous DNA helicase (DnaB(BA)) acted as a positive effector of primer synthesis...
  25. pmc Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames)
    Rafael M Couñago
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    BMC Struct Biol 9:53. 2009
    ..We also compare the native AlrBax structure to a recently reported structure of the same enzyme obtained through reductive lysine methylation...
  26. pmc Role of luxS in Bacillus anthracis growth and virulence factor expression
    Marcus B Jones
    Pathogen Functional Genomics Resource Center, J Craig Venter Institute, Rockville, MD, USA
    Virulence 1:72-83. 2010
    ..anthracis S-layer protein gene EA1 and pXO1 virulence genes. These data indicate that B. anthracis may use luxS/AI-2-mediated QS to regulate growth, density-dependent gene expression and virulence factor expression...
  27. pmc Contribution of lethal toxin and edema toxin to the pathogenesis of anthrax meningitis
    Celia M Ebrahimi
    Department of Biology and Center for Microbial Sciences, San Diego State University, 5500 Campanile Dr, San Diego, California 92182 4614, USA
    Infect Immun 79:2510-8. 2011
    ..Finally, in a murine model of anthrax meningitis, mice infected with the ΔLF mutant exhibited no mortality, brain bacterial load, or evidence of meningitis compared to mice infected with the parental or ΔEF strains...
  28. doi Lethal factor is not required for Bacillus anthracis virulence in guinea pigs and rabbits
    Haim Levy
    Department of Infectious Diseases, Israel Institute for Biological Research, 74100 Ness Ziona, Israel
    Microb Pathog 51:345-51. 2011
    ..These results indicate that unlike the data obtained in mice, the LF mutation does not abolish B. anthracis pathogenicity...
  29. doi CodY regulation is required for full virulence and heme iron acquisition in Bacillus anthracis
    Alice Château
    Unité des Toxines et Pathogénie Bactériennes, Laboratoire Pathogénie des Toxi Infections Bactériennes, Institut Pasteur, Paris, France
    FASEB J 25:4445-56. 2011
    ..The lack of CodY-mediated transcription weakens virulence by controlling iron acquisition and synthesis of toxin, but without modifying capsulation...
  30. pmc Structure of N5-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis
    Micheal L Tuntland
    Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA
    Acta Crystallogr D Biol Crystallogr 67:870-4. 2011
    ..Two interesting features of baPurK are a flexible B-loop (residues 149/150-157) that is in close contact with the active site and the binding of Mg2+ to the active site without additional ligands...
  31. doi Coenzyme A binding to the aminoglycoside acetyltransferase (3)-IIIb increases conformational sampling of antibiotic binding site
    Xiaohu Hu
    UT ORNL Center for Molecular Biophysics, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, United States
    Biochemistry 50:10559-65. 2011
    ....
  32. pmc Catalysis and sulfa drug resistance in dihydropteroate synthase
    Mi Kyung Yun
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Science 335:1110-4. 2012
    ..This substructure, together with the pterin-binding pocket, explains the roles of the conserved active-site residues and reveals how sulfonamide resistance arises...
  33. doi Elastic and inelastic diffraction changes upon variation of the relative humidity environment of PurE crystals
    R Oliete
    Plataforma Automatitzada de Cristal lografia, Barcelona, Spain
    Acta Crystallogr D Biol Crystallogr 69:194-212. 2013
    ....
  34. pmc Proteasome activity is required for anthrax lethal toxin to kill macrophages
    G Tang
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 67:3055-60. 1999
    ..Moreover, this proteasome-dependent process is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates...
  35. ncbi The structure of neutral protease from Bacillus cereus at 0.2-nm resolution
    W Stark
    Department of Structural Biology, University of Basel, Switzerland
    Eur J Biochem 207:781-91. 1992
    ..The high-resolution analysis allows detailed examination of possible causes for the difference in thermostability between neutral protease and thermolysin...
  36. pmc Site-directed mutagenesis of dicarboxylic acids near the active site of Bacillus cereus 5/B/6 beta-lactamase II
    H M Lim
    School of Life and Health Sciences, University of Delaware, Newark 19716
    Biochem J 276:401-4. 1991
    ..Conversion of Asp90 into Asn90 or Glu90 lead to the synthesis of inactive enzyme, suggesting that the spatial position of the beta-carboxy group of Asp90 is critical for enzyme function...
  37. ncbi Molecular characterization of immune inhibitor A, a secreted virulence protease from Bacillus thuringiensis
    A Lovgren
    Department of Microbiology, University of Stockholm, Sweden
    Mol Microbiol 4:2137-46. 1990
    ..The LD50 dose of purified InA protein injected in T. ni larvae was 12.5 +/- 2.5 ng per mg of larval body weight...
  38. pmc Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis
    S Makino
    Department of Bacteriology, University of Tokyo, Japan
    J Bacteriol 171:722-30. 1989
    ..anthracis. Using strains of B. anthracis with or without insertional inactivation of the cap region, we found that the capsule of B. anthracis conferred strong resistance to phagocytosis upon the bacterial host...
  39. ncbi Molecular characterization and sequence of phosphatidylinositol-specific phospholipase C of Bacillus thuringiensis
    M Lechner
    Institut fur Biologie II, University of Tubingen, FRG
    Mol Microbiol 3:621-6. 1989
    ..The enzyme from the E. coli recombinant shows no activity on other phospholipids and sphingomyelin. The cleaving specificity of PI-PLC was examined by thin layer chromatography...
  40. ncbi Structural homology between virulence-associated bacterial adenylate cyclases
    V Escuyer
    Unité des Antigènes Bactériens, Institut Pasteur, Paris, France
    Gene 71:293-8. 1988
    ..These data corroborate the immunological relatedness of the two enzymes and suggest that the two prokaryotic calmodulin-sensitive adenylate cyclases originate from a common ancestor...
  41. pmc An X-ray-crystallographic study of beta-lactamase II from Bacillus cereus at 0.35 nm resolution
    B J Sutton
    Department of Zoology, Oxford, U K
    Biochem J 248:181-8. 1987
    ..The structure of the apoenzyme at this resolution appears to differ from that of the Cd(II)-enzyme only in the orientation of two of the histidine residues and the cysteine residue that surround the metal ion...
  42. ncbi Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase
    D L Robertson
    Department of Chemistry, Brigham Young University, Provo, UT 84602
    Gene 73:363-71. 1988
    ..B. anthracis EF was not related to the Escherichia coli or yeast adenylate cyclases, but was related to the Bordetella pertussis calmodulin-dependent adenylate cyclase...
  43. ncbi Identification and characterization of a trans-activator involved in the regulation of encapsulation by Bacillus anthracis
    N J Vietri
    Division of Bacteriology, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702 5011
    Gene 152:1-9. 1995
    ..No cap-specific mRNA, and very low levels of ORF-specific mRNA, were detected in UUP5 containing the frameshift mutation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  44. ncbi Bacillus anthracis pXO1 virulence plasmid encodes a type 1 DNA topoisomerase
    A Fouet
    Laboratoire de Génétique Moléculaire des Toxines URA 557, CNRS, Institut Pasteur, Paris, France
    Mol Microbiol 11:471-9. 1994
    ..The regulation of expression from the topX promoter is modified by addition of a gyrase inhibiting antibiotic. The Topo X1 protein is likely to be involved in the stability of pXO1...
  45. ncbi Molecular cloning of the hom-thrC-thrB cluster from Bacillus sp. ULM1: expression of the thrC gene in Escherichia coli and corynebacteria, and evolutionary relationships of the threonine genes
    M Malumbres
    Department of Ecology, Genetics and Microbiology, Faculty of Biology, University of Leon, Spain
    Folia Microbiol (Praha) 40:595-606. 1995
    ..Amino acid comparison of nine threonine synthases revealed evolutionary relationships between different groups of bacteria...
  46. ncbi Secondary structure of anthrax lethal toxin proteins and their interaction with large unilamellar vesicles: a fourier-transform infrared spectroscopy approach
    X M Wang
    Laboratoire de Chimie Physique des Macromolecules aux Interfaces, Universite Libre de Bruxelles, Belgium
    Biochemistry 35:14939-46. 1996
    ....
  47. pmc Cloning and nucleotide sequence analysis of gyrB of Bacillus cereus, B. thuringiensis, B. mycoides, and B. anthracis and their application to the detection of B. cereus in rice
    S Yamada
    Central Research Laboratory, Nippon Suisan Kaisha, Ltd, Hachioji City, Tokyo 192, Japan
    Appl Environ Microbiol 65:1483-90. 1999
    ..This method enabled us to detect an initial inoculum of 0.24 CFU of B. cereus cells per g of boiled rice food homogenate without extracting DNA. However, a simple two-step filtration step is required to remove PCR inhibitory substances...
  48. pmc Replication mechanism and sequence analysis of the replicon of pAW63, a conjugative plasmid from Bacillus thuringiensis
    A Wilcks
    National Institute of Occupational Health, Copenhagen, Denmark
    J Bacteriol 181:3193-200. 1999
    ..Hybridization experiments using the cloned replicon as a probe showed that pAW63 has similarity to large plasmids from other B. thuringiensis subsp. kurstaki strains and to a strain of B. thuringiensis subsp. alesti...
  49. ncbi The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor
    Benjamin E Turk
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Struct Mol Biol 11:60-6. 2004
    ..The crystal structures of LF bound to an optimized peptide substrate and to peptide-based inhibitors provide a rationale for the observed selectivity and may be exploited in the design of future generations of LF inhibitors...
  50. pmc vrrB, a hypervariable open reading frame in Bacillus anthracis
    J M Schupp
    Department of Biological Sciences, Northern Arizona University, Flagstaff 86011 5640, USA
    J Bacteriol 182:3989-97. 2000
    ..anthracis. Evolution of hypervariable genes can negate the lack of genetic variability in species such as B. anthracis and provide select rapid evolution in other more variable species...
  51. pmc Structural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamase
    L Chantalat
    Laboratoire de Cristallographie Macromoléculaire, Institut de Biologie Structurale Jean Pierre Ebel, CNRS CEA, Grenoble, France
    Protein Sci 9:1402-6. 2000
    ..The evolution of a large superfamily including Zn-beta-lactamases suggests that they may not all share the same mechanism...
  52. ncbi Deletion of aprA and nprA genes for alkaline protease A and neutral protease A from bacillus thuringiensis: effect on insecticidal crystal proteins
    Y Tan
    Ecogen, Inc, 2000 Cabot Boulevard West, Langhorne, Pennsylvania, PA 19047, USA
    J Biotechnol 84:67-72. 2001
    ..These results suggest that enhanced yield of certain crystal proteins can be obtained by deletion of the genes aprA and nprA which are the major extracellular proteases of B. thuringiensis...
  53. pmc GerN, an antiporter homologue important in germination of Bacillus cereus endospores
    P D Thackray
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom
    J Bacteriol 183:476-82. 2001
    ..Since germination in suboptimal concentrations of L-alanine shows a delay, additional germination transporters may be required for optimal response at low germinant concentrations...
  54. ncbi Hydrophobic residues Phe552, Phe554, Ile562, Leu566, and Ile574 are required for oligomerization of anthrax protective antigen
    N Ahuja
    Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India
    Biochem Biophys Res Commun 287:542-9. 2001
    ..Consequently, these mutants became nontoxic in combination with lethal factor and edema factor. Therapeutic importance of these mutants and their potential as vaccine candidates is discussed...
  55. ncbi Toxins of Bacillus anthracis
    F Brossier
    Unité des Toxines et Pathogénie Bactériennes URA CNRS 2172, Institut Pasteur, 28 rue du Docteur Roux, 75725 15, Paris Cedex, France
    Toxicon 39:1747-55. 2001
    ..Progress in the structure-function relationship of these three proteins, their regulation mechanisms and their roles in pathogenesis and immunoprotection will be exposed...
  56. ncbi Crystal structure of the anthrax lethal factor
    A D Pannifer
    Biochemistry Department, University of Leicester, Leicester LE1 7RH, UK
    Nature 414:229-33. 2001
    ..The structure thus reveals a protein that has evolved through a process of gene duplication, mutation and fusion, into an enzyme with high and unusual specificity...
  57. ncbi Isolation and expression of a Bacillus cereus gene encoding benzil reductase
    R Maruyama
    Department of Cell Engineering, Faculty of Engineering, Toyama University, Toyama, Japan
    Biotechnol Bioeng 75:630-3. 2001
    ....
  58. pmc Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus species
    Yi Hu Dong
    Institute of Molecular Agrobiology, National University of Singapore, Singapore 117604
    Appl Environ Microbiol 68:1754-9. 2002
    ..Sequence comparison of the gene products and motif analysis showed that the gene products belong to the same family of AHL lactonases...
  59. pmc Identification of amino acid residues of anthrax protective antigen involved in binding with lethal factor
    Vibha Chauhan
    Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India
    Infect Immun 70:4477-84. 2002
    ..It was concluded that residues 202, 203, 205, and 207 of PA are essential for the binding of LF to PA...
  60. pmc A cell-cell signaling peptide activates the PlcR virulence regulon in bacteria of the Bacillus cereus group
    Leyla Slamti
    Unité de Biochimie Microbienne, CNRS URA2172, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France
    EMBO J 21:4550-9. 2002
    ..This activating mechanism was found to be strain specific, with this specificity determined by the first residue of the penta peptide...
  61. pmc Requirement of flhA for swarming differentiation, flagellin export, and secretion of virulence-associated proteins in Bacillus thuringiensis
    Emilia Ghelardi
    Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, Universita degli Studi di Pisa, 56127 Pisa, Italy
    J Bacteriol 184:6424-33. 2002
    ..thuringiensis may be coordinately regulated by flhA, which appears to play a crucial role in the export of flagellar as well as nonflagellar proteins...
  62. ncbi The role of the pro-sequence in the processing and secretion of the thermolysin-like neutral protease from Bacillus cereus
    D R Wetmore
    Department of Biological Sciences, University of Calgary, Alberta, Canada
    Mol Microbiol 6:1593-604. 1992
    ..N-terminal analysis of the mutant mature protein demonstrates that the processing site is unaltered by the pro-sequence deletion. The deletion must, therefore, modulate the kinetics of processing and/or secretion of the pro-protein...
  63. ncbi Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough
    Sandriyana Soelaiman
    Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:25990-7. 2003
    ..It may serve as a lead to design antitoxins to address the role of adenylyl cyclase toxins in bacterial pathogenesis and to fight against anthrax and whooping cough...

Research Grants3

  1. Genetics Modifiers of Anthrax Lethal Toxin Induced Pathophysiology
    Kenneth Bradley; Fiscal Year: 2008
    ..abstract_text> ..
  2. CHARACTERIZATION OF ANTHRAX TOXIN RECEPTOR INTERACTIONS
    Kenneth Bradley; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  3. Genetics Modifiers of Anthrax Lethal Toxin Induced Pathophysiology
    KENNETH ALAN BRADLEY; Fiscal Year: 2010
    ..abstract_text> ..

Patents10

  1. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  2. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  3. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  4. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  5. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  6. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  7. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  8. ANTIMICROBIAL AGENTS
    Patent Number: WO2013114363-A2; Date:2013-08-08
  9. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  10. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27