Genomes and Genes
Bacillus anthracis str. 'Ames Ancestor'
Alias: Bacillus anthracis Ames "Ancestor", Bacillus anthracis str. Ames 0581, Bacillus anthracis str. Ames Ancestor, Bacillus anthracis strain 'Ames Ancestor'
- Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factorN S Duesbery
Advanced BioScience Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702
Science 280:734-7. 1998..The identification of a cleavage site for LF may facilitate the development of LF inhibitors...
- Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophagesG Vitale
Dipartimento di Scienze Biomediche, Universita di Padova, Italy
Biochem Biophys Res Commun 248:706-11. 1998..The possible implications of these findings for the cytolysis of macrophage cells induced by LF are discussed. These results open the way to the design and screening of specific inhibitors of LF...
- Proteolytic activation of receptor-bound anthrax protective antigen on macrophages promotes its internalizationK E Beauregard
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
Cell Microbiol 2:251-8. 2000..The relatively long period of activation and internalization of PA at the cell surface may reflect adaptation of this binary toxin that maximizes self-assembly...
- Vector-mediated selective expression of lethal factor, a toxic element of Bacillus anthracis, damages A549 cells via inhibition of MAPK and AKT pathwaysWenlei Zhuo
Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China
Int J Med Sci 10:292-8. 2013..The results also revealed that the inhibition of mitogen-activated protein kinase and AKT pathways was partially involved in the process. Thus, hTERTp-regulated LF increase could be a promising approach in lung cancer-targeted therapy...
- Purification, crystallization and preliminary structural analysis of nucleoside diphosphate kinase from Bacillus anthracisGauri Misra
Molecular and Structural Biology Division, Central Drug Research Institute, PO Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow 226 001, India
Acta Crystallogr Sect F Struct Biol Cryst Commun 63:1084-6. 2007..3 A. The crystals are hexagonal in shape and belong to space group P6(3)22. The crystals contain a monomer in the asymmetric unit, which corresponds to a Matthews coefficient (V(M)) of 2.1 A(3) Da(-1) and a solvent content of about 36.9%...
- Preparation of a positive control DNA for molecular diagnosis of Bacillus anthracisSatoshi Inoue
Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
Jpn J Infect Dis 57:29-32. 2004..It also allows the detection of possible cross contamination, indicating that this strategy would be useful and convenient for the molecular identification of not only B. anthracis but also other highly pathogenic microbes...
- Identification and characterization of a novel toxin-antitoxin module from Bacillus anthracisShivangi Agarwal
School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India
FEBS Lett 581:1727-34. 2007..Gel retardation assays demonstrated that PemI binds to its upstream DNA sequence. This study reports the first evidence of an active chromosome encoded toxin-antitoxin locus in B. anthracis...
- Anthrax edema toxin sensitizes DBA/2J mice to lethal toxinAaron M Firoved
National Institute of Allergy and Infectious Diseases, National Institutes of Health, 30 Convent Dr, Building 30, Room 303, Bethesda, MD 20892 4349, USA
Infect Immun 75:2120-5. 2007..g., 15 microg) given to male and female DBA/2J mice 18 h prior to LT challenge also sensitize them to LT. This study using highly purified ET and LT demonstrates how the components of anthrax toxin can work together to increase lethality...
- Insertion of anthrax protective antigen into liposomal membranes: effects of a receptorJianjun Sun
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 282:1059-65. 2007....
- Identification and characterization of a germination operon from Bacillus thuringiensisYuling Gai
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Science, Beijing, 100080, P R China
Antonie Van Leeuwenhoek 89:251-9. 2006..These results suggest this operon is essential for normal spore germination in B. thuringiensis. The expression of cwlJ was observed in the sporulating cells through Western blot experiments...
- A Bacillus thuringiensis S-layer protein involved in toxicity against Epilachna varivestis (Coleoptera: Coccinellidae)Guadalupe Peña
Instituto de Biotecnologia, UNAM, Ap Postal 510 3, Cuernavaca 62250, Morelos, Mexico
Appl Environ Microbiol 72:353-60. 2006..anthracis, B. licheniformis, and B. thuringiensis are arranged in the same main group, suggesting similar origins. This is the first report that demonstrates that an S-layer protein is directly involved in toxicity to a coleopteran pest...
- Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domainDavid G Waterman
York Structural Biology Laboratory, University of York, Chemistry Department, York YO10 5YW, UK
J Mol Biol 356:97-110. 2006..The inaccessibility of U8 in the canonical L-shaped form of tRNA, and the existence of a glycine-rich linker joining the catalytic and RNA-binding moieties of ThiI suggest that structural changes may occur in both molecules upon binding...
- The DNA-binding specificity of the Bacillus anthracis AbrB proteinMark A Strauch
Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
Microbiology 151:1751-9. 2005..In B. subtilis cells, the B. anthracis promoters from the atxA and abrB genes were regulated by AbrB(BS), and the B. subtilis promoter from the yxbB operon was regulated by AbrB(BA)...
- Anthrax lethal factor inhibitionW L Shoop
Merck Research Laboratories, Rahway, NJ 07065, USA
Proc Natl Acad Sci U S A 102:7958-63. 2005..These results indicate that a small molecule, hydroxamate LF inhibitor, as revealed herein, can ameliorate the toxemia characteristic of an active B. anthracis infection and could be a vital adjunct to our ability to combat anthrax...
- High-level expression and characterization of two chitinases, ChiCH and ChiCW, of Bacillus cereus 28-9 in Escherichia coliChien Jui Huang
Department of Plant Pathology and Microbiology, National Taiwan University, Taipei 106, Taiwan
Biochem Biophys Res Commun 327:8-17. 2005..Therefore, the method of high-level expression of chitinases is helpful to studies and applications of chitinases...
- Distinct mutations in PlcR explain why some strains of the Bacillus cereus group are nonhemolyticLeyla Slamti
Groupe Génétique et Physiologie des Bacillus pathogènes, Institut Pasteur, 75015 Paris, France
J Bacteriol 186:3531-8. 2004..We also found that the plcR genes of three B. anthracis strains belonging to different phylogenetic groups contained the same nonsense mutation, suggesting that this mutation is a distinctive trait of this species...
- Characterization of a major Bacillus anthracis spore coat protein and its role in spore inactivationHo San Kim
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
J Bacteriol 186:2413-7. 2004..Since Cot alpha is an abundant outer spore coat protein of the B. cereus group with a prominent role in spore resistance and sensitivity, it is a promising target for the inactivation of B. anthracis spores...
- Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxinsYuequan Shen
Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
EMBO J 21:6721-32. 2002..However, CyaA is fully activated by CaM without the domain corresponding to the helical domain of EF...
- The type III pantothenate kinase encoded by coaX is essential for growth of Bacillus anthracisCarleitta Paige
Center for Structural Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Bacteriol 190:6271-5. 2008..We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanK(Ba) is an essential enzyme, thus contributing to its validation as a new antimicrobial target...
- Dual promoters control expression of the Bacillus anthracis virulence factor AtxACristina Bongiorni
Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Bacteriol 190:6483-92. 2008..The dual promoter activity and the extended untranslated mRNA suggest that as-yet-unknown regulatory mechanisms may act on this region to influence the level of AtxA in the cell...
- Structural studies of shikimate dehydrogenase from Bacillus anthracis complexed with cofactor NADPGuy Barros Barcellos
Faculdade de Biociencias, Laboratório de Bioquímica Estrutural, Pontificia Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS, Brazil
J Mol Model 15:147-55. 2009..This study was able to identify the main residues of the NADP binding site responsible for ligand affinities. This structural study can be used in the design of more specific drugs against infectious diseases...
- Bacillus anthracis edema toxin suppresses human macrophage phagocytosis and cytoskeletal remodeling via the protein kinase A and exchange protein activated by cyclic AMP pathwaysLinsey A Yeager
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 0610, USA
Infect Immun 77:2530-43. 2009..These results suggested that EdTx weakened the host immune response by increasing cAMP levels, which then signaled via PKA and Epac to cripple MPhi phagocytosis and interfered with cytoskeletal remodeling...
- Anthrax lethal toxin impairs IL-8 expression in epithelial cells through inhibition of histone H3 modificationBenoit Raymond
Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
PLoS Pathog 5:e1000359. 2009..This epigenetic reprogramming, in addition to previously reported effects of LT, may represent an efficient strategy used by B. anthracis for invading the host...
- Mechanisms of DNA binding and regulation of Bacillus anthracis DNA primaseSubhasis B Biswas
Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
Biochemistry 48:7373-82. 2009..anthracis and E. coli; however, between DnaB proteins derived from these two organisms, only the homologous DNA helicase (DnaB(BA)) acted as a positive effector of primer synthesis...
- Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames)Rafael M Couñago
Department of Biochemistry, University of Otago, Dunedin, New Zealand
BMC Struct Biol 9:53. 2009..We also compare the native AlrBax structure to a recently reported structure of the same enzyme obtained through reductive lysine methylation...
- Role of luxS in Bacillus anthracis growth and virulence factor expressionMarcus B Jones
Pathogen Functional Genomics Resource Center, J Craig Venter Institute, Rockville, MD, USA
Virulence 1:72-83. 2010..anthracis S-layer protein gene EA1 and pXO1 virulence genes. These data indicate that B. anthracis may use luxS/AI-2-mediated QS to regulate growth, density-dependent gene expression and virulence factor expression...
- Contribution of lethal toxin and edema toxin to the pathogenesis of anthrax meningitisCelia M Ebrahimi
Department of Biology and Center for Microbial Sciences, San Diego State University, 5500 Campanile Dr, San Diego, California 92182 4614, USA
Infect Immun 79:2510-8. 2011..Finally, in a murine model of anthrax meningitis, mice infected with the ΔLF mutant exhibited no mortality, brain bacterial load, or evidence of meningitis compared to mice infected with the parental or ΔEF strains...
- Lethal factor is not required for Bacillus anthracis virulence in guinea pigs and rabbitsHaim Levy
Department of Infectious Diseases, Israel Institute for Biological Research, 74100 Ness Ziona, Israel
Microb Pathog 51:345-51. 2011..These results indicate that unlike the data obtained in mice, the LF mutation does not abolish B. anthracis pathogenicity...
- CodY regulation is required for full virulence and heme iron acquisition in Bacillus anthracisAlice Château
Unité des Toxines et Pathogénie Bactériennes, Laboratoire Pathogénie des Toxi Infections Bactériennes, Institut Pasteur, Paris, France
FASEB J 25:4445-56. 2011..The lack of CodY-mediated transcription weakens virulence by controlling iron acquisition and synthesis of toxin, but without modifying capsulation...
- Structure of N5-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracisMicheal L Tuntland
Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA
Acta Crystallogr D Biol Crystallogr 67:870-4. 2011..Two interesting features of baPurK are a flexible B-loop (residues 149/150-157) that is in close contact with the active site and the binding of Mg2+ to the active site without additional ligands...
- Coenzyme A binding to the aminoglycoside acetyltransferase (3)-IIIb increases conformational sampling of antibiotic binding siteXiaohu Hu
UT ORNL Center for Molecular Biophysics, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, United States
Biochemistry 50:10559-65. 2011....
- Catalysis and sulfa drug resistance in dihydropteroate synthaseMi Kyung Yun
Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Science 335:1110-4. 2012..This substructure, together with the pterin-binding pocket, explains the roles of the conserved active-site residues and reveals how sulfonamide resistance arises...
- Elastic and inelastic diffraction changes upon variation of the relative humidity environment of PurE crystalsR Oliete
Plataforma Automatitzada de Cristal lografia, Barcelona, Spain
Acta Crystallogr D Biol Crystallogr 69:194-212. 2013....
- Proteasome activity is required for anthrax lethal toxin to kill macrophagesG Tang
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Infect Immun 67:3055-60. 1999..Moreover, this proteasome-dependent process is an early step in LeTx intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates...
- The structure of neutral protease from Bacillus cereus at 0.2-nm resolutionW Stark
Department of Structural Biology, University of Basel, Switzerland
Eur J Biochem 207:781-91. 1992..The high-resolution analysis allows detailed examination of possible causes for the difference in thermostability between neutral protease and thermolysin...
- Site-directed mutagenesis of dicarboxylic acids near the active site of Bacillus cereus 5/B/6 beta-lactamase IIH M Lim
School of Life and Health Sciences, University of Delaware, Newark 19716
Biochem J 276:401-4. 1991..Conversion of Asp90 into Asn90 or Glu90 lead to the synthesis of inactive enzyme, suggesting that the spatial position of the beta-carboxy group of Asp90 is critical for enzyme function...
- Molecular characterization of immune inhibitor A, a secreted virulence protease from Bacillus thuringiensisA Lovgren
Department of Microbiology, University of Stockholm, Sweden
Mol Microbiol 4:2137-46. 1990..The LD50 dose of purified InA protein injected in T. ni larvae was 12.5 +/- 2.5 ng per mg of larval body weight...
- Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracisS Makino
Department of Bacteriology, University of Tokyo, Japan
J Bacteriol 171:722-30. 1989..anthracis. Using strains of B. anthracis with or without insertional inactivation of the cap region, we found that the capsule of B. anthracis conferred strong resistance to phagocytosis upon the bacterial host...
- Molecular characterization and sequence of phosphatidylinositol-specific phospholipase C of Bacillus thuringiensisM Lechner
Institut fur Biologie II, University of Tubingen, FRG
Mol Microbiol 3:621-6. 1989..The enzyme from the E. coli recombinant shows no activity on other phospholipids and sphingomyelin. The cleaving specificity of PI-PLC was examined by thin layer chromatography...
- Structural homology between virulence-associated bacterial adenylate cyclasesV Escuyer
Unité des Antigènes Bactériens, Institut Pasteur, Paris, France
Gene 71:293-8. 1988..These data corroborate the immunological relatedness of the two enzymes and suggest that the two prokaryotic calmodulin-sensitive adenylate cyclases originate from a common ancestor...
- An X-ray-crystallographic study of beta-lactamase II from Bacillus cereus at 0.35 nm resolutionB J Sutton
Department of Zoology, Oxford, U K
Biochem J 248:181-8. 1987..The structure of the apoenzyme at this resolution appears to differ from that of the Cd(II)-enzyme only in the orientation of two of the histidine residues and the cysteine residue that surround the metal ion...
- Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclaseD L Robertson
Department of Chemistry, Brigham Young University, Provo, UT 84602
Gene 73:363-71. 1988..B. anthracis EF was not related to the Escherichia coli or yeast adenylate cyclases, but was related to the Bordetella pertussis calmodulin-dependent adenylate cyclase...
- Identification and characterization of a trans-activator involved in the regulation of encapsulation by Bacillus anthracisN J Vietri
Division of Bacteriology, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702 5011
Gene 152:1-9. 1995..No cap-specific mRNA, and very low levels of ORF-specific mRNA, were detected in UUP5 containing the frameshift mutation.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Bacillus anthracis pXO1 virulence plasmid encodes a type 1 DNA topoisomeraseA Fouet
Laboratoire de Génétique Moléculaire des Toxines URA 557, CNRS, Institut Pasteur, Paris, France
Mol Microbiol 11:471-9. 1994..The regulation of expression from the topX promoter is modified by addition of a gyrase inhibiting antibiotic. The Topo X1 protein is likely to be involved in the stability of pXO1...
- Molecular cloning of the hom-thrC-thrB cluster from Bacillus sp. ULM1: expression of the thrC gene in Escherichia coli and corynebacteria, and evolutionary relationships of the threonine genesM Malumbres
Department of Ecology, Genetics and Microbiology, Faculty of Biology, University of Leon, Spain
Folia Microbiol (Praha) 40:595-606. 1995..Amino acid comparison of nine threonine synthases revealed evolutionary relationships between different groups of bacteria...
- Secondary structure of anthrax lethal toxin proteins and their interaction with large unilamellar vesicles: a fourier-transform infrared spectroscopy approachX M Wang
Laboratoire de Chimie Physique des Macromolecules aux Interfaces, Universite Libre de Bruxelles, Belgium
Biochemistry 35:14939-46. 1996....
- Cloning and nucleotide sequence analysis of gyrB of Bacillus cereus, B. thuringiensis, B. mycoides, and B. anthracis and their application to the detection of B. cereus in riceS Yamada
Central Research Laboratory, Nippon Suisan Kaisha, Ltd, Hachioji City, Tokyo 192, Japan
Appl Environ Microbiol 65:1483-90. 1999..This method enabled us to detect an initial inoculum of 0.24 CFU of B. cereus cells per g of boiled rice food homogenate without extracting DNA. However, a simple two-step filtration step is required to remove PCR inhibitory substances...
- Replication mechanism and sequence analysis of the replicon of pAW63, a conjugative plasmid from Bacillus thuringiensisA Wilcks
National Institute of Occupational Health, Copenhagen, Denmark
J Bacteriol 181:3193-200. 1999..Hybridization experiments using the cloned replicon as a probe showed that pAW63 has similarity to large plasmids from other B. thuringiensis subsp. kurstaki strains and to a strain of B. thuringiensis subsp. alesti...
- The structural basis for substrate and inhibitor selectivity of the anthrax lethal factorBenjamin E Turk
Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nat Struct Mol Biol 11:60-6. 2004..The crystal structures of LF bound to an optimized peptide substrate and to peptide-based inhibitors provide a rationale for the observed selectivity and may be exploited in the design of future generations of LF inhibitors...
- vrrB, a hypervariable open reading frame in Bacillus anthracisJ M Schupp
Department of Biological Sciences, Northern Arizona University, Flagstaff 86011 5640, USA
J Bacteriol 182:3989-97. 2000..anthracis. Evolution of hypervariable genes can negate the lack of genetic variability in species such as B. anthracis and provide select rapid evolution in other more variable species...
- Structural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamaseL Chantalat
Laboratoire de Cristallographie Macromoléculaire, Institut de Biologie Structurale Jean Pierre Ebel, CNRS CEA, Grenoble, France
Protein Sci 9:1402-6. 2000..The evolution of a large superfamily including Zn-beta-lactamases suggests that they may not all share the same mechanism...
- Deletion of aprA and nprA genes for alkaline protease A and neutral protease A from bacillus thuringiensis: effect on insecticidal crystal proteinsY Tan
Ecogen, Inc, 2000 Cabot Boulevard West, Langhorne, Pennsylvania, PA 19047, USA
J Biotechnol 84:67-72. 2001..These results suggest that enhanced yield of certain crystal proteins can be obtained by deletion of the genes aprA and nprA which are the major extracellular proteases of B. thuringiensis...
- GerN, an antiporter homologue important in germination of Bacillus cereus endosporesP D Thackray
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom
J Bacteriol 183:476-82. 2001..Since germination in suboptimal concentrations of L-alanine shows a delay, additional germination transporters may be required for optimal response at low germinant concentrations...
- Hydrophobic residues Phe552, Phe554, Ile562, Leu566, and Ile574 are required for oligomerization of anthrax protective antigenN Ahuja
Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India
Biochem Biophys Res Commun 287:542-9. 2001..Consequently, these mutants became nontoxic in combination with lethal factor and edema factor. Therapeutic importance of these mutants and their potential as vaccine candidates is discussed...
- Toxins of Bacillus anthracisF Brossier
Unité des Toxines et Pathogénie Bactériennes URA CNRS 2172, Institut Pasteur, 28 rue du Docteur Roux, 75725 15, Paris Cedex, France
Toxicon 39:1747-55. 2001..Progress in the structure-function relationship of these three proteins, their regulation mechanisms and their roles in pathogenesis and immunoprotection will be exposed...
- Crystal structure of the anthrax lethal factorA D Pannifer
Biochemistry Department, University of Leicester, Leicester LE1 7RH, UK
Nature 414:229-33. 2001..The structure thus reveals a protein that has evolved through a process of gene duplication, mutation and fusion, into an enzyme with high and unusual specificity...
- Isolation and expression of a Bacillus cereus gene encoding benzil reductaseR Maruyama
Department of Cell Engineering, Faculty of Engineering, Toyama University, Toyama, Japan
Biotechnol Bioeng 75:630-3. 2001....
- Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus speciesYi Hu Dong
Institute of Molecular Agrobiology, National University of Singapore, Singapore 117604
Appl Environ Microbiol 68:1754-9. 2002..Sequence comparison of the gene products and motif analysis showed that the gene products belong to the same family of AHL lactonases...
- Identification of amino acid residues of anthrax protective antigen involved in binding with lethal factorVibha Chauhan
Centre for Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India
Infect Immun 70:4477-84. 2002..It was concluded that residues 202, 203, 205, and 207 of PA are essential for the binding of LF to PA...
- A cell-cell signaling peptide activates the PlcR virulence regulon in bacteria of the Bacillus cereus groupLeyla Slamti
Unité de Biochimie Microbienne, CNRS URA2172, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France
EMBO J 21:4550-9. 2002..This activating mechanism was found to be strain specific, with this specificity determined by the first residue of the penta peptide...
- Requirement of flhA for swarming differentiation, flagellin export, and secretion of virulence-associated proteins in Bacillus thuringiensisEmilia Ghelardi
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, Universita degli Studi di Pisa, 56127 Pisa, Italy
J Bacteriol 184:6424-33. 2002..thuringiensis may be coordinately regulated by flhA, which appears to play a crucial role in the export of flagellar as well as nonflagellar proteins...
- The role of the pro-sequence in the processing and secretion of the thermolysin-like neutral protease from Bacillus cereusD R Wetmore
Department of Biological Sciences, University of Calgary, Alberta, Canada
Mol Microbiol 6:1593-604. 1992..N-terminal analysis of the mutant mature protein demonstrates that the processing site is unaltered by the pro-sequence deletion. The deletion must, therefore, modulate the kinetics of processing and/or secretion of the pro-protein...
- Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping coughSandriyana Soelaiman
Ben May Institute for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 278:25990-7. 2003..It may serve as a lead to design antitoxins to address the role of adenylyl cyclase toxins in bacterial pathogenesis and to fight against anthrax and whooping cough...
- Genetics Modifiers of Anthrax Lethal Toxin Induced PathophysiologyKenneth Bradley; Fiscal Year: 2008..abstract_text> ..
- CHARACTERIZATION OF ANTHRAX TOXIN RECEPTOR INTERACTIONSKenneth Bradley; Fiscal Year: 2008..unreadable] [unreadable]..
- Genetics Modifiers of Anthrax Lethal Toxin Induced PathophysiologyKENNETH ALAN BRADLEY; Fiscal Year: 2010..abstract_text> ..
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