Genomes and Genes
Plasmodium falciparum 3D7
Alias: Plasmodium falciparum (isolate 3D7), PLASMODIUM FALCIPARUM (ISOLATE 3D7).
Publications210 found, 100 shown here
- In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in AfricaChristin Sisowath
Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
J Infect Dis 199:750-7. 2009..Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for the detection and surveillance of AL resistance...
- In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)Christin Sisowath
Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
J Infect Dis 191:1014-7. 2005..This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings...
- Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparumChristopher J Tonkin
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
PLoS Biol 7:e84. 2009..This work highlights the pivotal but distinct role for both PfSir2 paralogues in epigenetic silencing of P. falciparum virulence genes and the control of pathogenicity of malaria infection...
- A multifunctional serine protease primes the malaria parasite for red blood cell invasionKonstantinos Koussis
Division of Parasitology, National Institute for Medical Research, London, UK
EMBO J 28:725-35. 2009..We propose that PfSUB1 is a multifunctional processing protease with an essential role in both egress of the malaria merozoite and remodelling of its surface in preparation for erythrocyte invasion...
- P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1J A Rowe
Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
Nature 388:292-5. 1997..Thus we describe a new adhesive function for PfEMP1 and raise the possibility that CR1 polymorphisms in Africans that influence the interaction between erythrocytes and PfEMP1 may protect against severe malaria...
- The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinaseJudith L Green
Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
J Biol Chem 283:30980-9. 2008..Both CDPK1 activity and host cell invasion can be inhibited by the kinase inhibitor K252a, suggesting that CDPK1 is a suitable target for antimalarial drug development...
- H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3Richard Bartfai
Department of Molecular Biology, Radboud University, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
PLoS Pathog 6:e1001223. 2010..Furthermore, our findings place H2A.Z at the cradle of P. falciparum epigenetic regulation by stably defining intergenic regions and providing a platform for dynamic assembly of epigenetic and other transcription related complexes...
- Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparumStephanie G Valderramos
Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America
PLoS Pathog 6:e1000887. 2010....
- Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasitesLucio H Freitas-Junior
Institut Pasteur, Biology of Host Parasite Interactions Unit CNRS URA2581, 25, rue du Dr Roux, 75724 Paris, France
Cell 121:25-36. 2005..Our data demonstrate that mutually exclusive transcription of var genes is linked to the dynamic remodeling of chromatin...
- Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growthMatthew A Child
Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Mol Microbiol 78:187-202. 2010..Our findings show that correct spatiotemporal regulation of MSP1 maturation is crucial for the function of the protein and for maintenance of the parasite asexual blood-stage life cycle...
- Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparumPuran S Sijwali
Department of Medicine, San Francisco General Hospital, University of California San Francisco, CA 94143 0811, USA
Mol Biochem Parasitol 150:96-106. 2006..Our data suggest key roles for falcipain-2 and falcipain-3 in the development of erythrocytic malaria parasites and a complex interplay between P. falciparum cysteine and aspartic proteases...
- Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasiteKerstin Leykauf
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
PLoS Pathog 6:e1000941. 2010..In addition to shedding unexpected new light on AMA1 function, this work represents the first time PKA has been implicated in merozoite invasion...
- Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparumM B Reed
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Nature 403:906-9. 2000..This has important implications for the development and efficacy of future antimalarial agents...
- A conserved multi-gene family induces cross-reactive antibodies effective in defense against Plasmodium falciparumSubhash Singh
Bio medical Parasitology Unit, Institut Pasteur, Paris, France
PLoS ONE 4:e5410. 2009..Both MSP3 and MSP6 share a common characteristic small N-terminal signature amino-acid stretch (NLRNA/G), a feature similar to MSP3-like orthologs identified in other human and primate malaria parasites...
- Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparumMarina Chavchich
Australian Army Malaria Institute, Gallipoli Barracks, Enoggera, Australia
Antimicrob Agents Chemother 54:2455-64. 2010..This observation is of practical importance, because artemisinin drugs are often used in combination with mefloquine for the treatment of malaria...
- Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing proteaseNatalie C Silmon de Monerri
Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
Infect Immun 79:1086-97. 2011..Our findings imply multiple roles for PfSUB1 in the parasite life cycle, further supporting the case for considering the protease as a potential new antimalarial drug target...
- Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathwayEeshita G Dastidar
Biology of Host Parasite Interactions Unit, Institut Pasteur, 25 rue du Dr Roux, F 75724 Paris, France
BMC Biol 10:5. 2012..The parasite's genome encodes one catalytic subunit, PfCK2α, which we have previously shown to be essential for completion of the asexual erythrocytic cycle, and two putative regulatory subunits, PfCK2β1 and PfCK2β2...
- Tracking Glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparumJeffrey A Yeoman
La Trobe University, Biochemistry Department, Bundoora, Australia
Eukaryot Cell 10:556-64. 2011..Replacement of the acid phosphatase homology domain of PfGAP50 with GFP appears to allow correct trafficking of the chimera but confers a growth disadvantage...
- Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMPOnyinyechukwu Uchime
Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
Eukaryot Cell 11:615-25. 2012..MTRAP- and in general PTRAMP-specific antibodies failed to inhibit P. falciparum development in vitro. Altogether, MTRAP is a highly extended bifunctional protein that binds to an erythrocyte receptor and the merozoite motor...
- Effects of calcium signaling on Plasmodium falciparum erythrocyte invasion and post-translational modification of gliding-associated protein 45 (PfGAP45)Matthew L Jones
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Mol Biochem Parasitol 168:55-62. 2009..falciparum erythrocyte invasion and reveals that the assembly status of the merozoite glideosome, which is central to erythrocyte invasion, is surprisingly dynamic...
- Plasmodium falciparum reticulocyte binding-like homologue protein 2 (PfRH2) is a key adhesive molecule involved in erythrocyte invasionTajali Sahar
Malaria Group, International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi, India
PLoS ONE 6:e17102. 2011..PfRH2a/2b thus plays a key role in erythrocyte invasion and its conserved receptor-binding domain deserves attention as a promising candidate for inclusion in a blood-stage malaria vaccine...
- Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparumK K Eggleson
Howard Hughes Medical Institute, Washington University, Department of Molecular Microbiology, St Louis, Missouri 63110, USA
J Biol Chem 274:32411-7. 1999..The characterization of falcilysin increases our understanding of hemoglobin catabolism in P. falciparum and the unusual M16 family of metallopeptidases...
- Export of PfSBP1 to the Plasmodium falciparum Maurer's cleftsTheodora Saridaki
Hygiene Institut, Abteilung Parasitologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
Traffic 10:137-52. 2009..Our findings suggest new principles of protein export in P. falciparum-infected erythrocytes...
- Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14Malcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:531-4. 2002..We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome...
- Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in AfricaSabina Dahlström
Malaria Research, Karolinska Institutet, Stockholm, Sweden
J Infect Dis 200:1456-64. 2009..Our data suggest for the first time, to our knowledge, the involvement of pfMRP1 in P. falciparum in vivo response to ACT...
- Hemoglobin metabolism in the malaria parasite Plasmodium falciparumS E Francis
Howard Hughes Medical Institute, Department of Molecular Microbiology and Barnes Jewish Hospital, St Louis, Missouri 63110, USA
Annu Rev Microbiol 51:97-123. 1997..Understanding the disposition of hemoglobin has allowed identification of essential processes and metabolic weakpoints that can be exploited to combat this scourge of mankind...
- Mosquito heparan sulfate and its potential role in malaria infection and transmissionPhotini Sinnis
Department of Medical Parasitology, New York University School of Medicine, New York, New York 10010, USA
J Biol Chem 282:25376-84. 2007..The heparan sulfate isolated from the whole mosquito binds to circumsporozoite protein, suggesting a role within the mosquito for infection and transmission of the Plasmodium parasite...
- The novel heme oxygenase-like protein from Plasmodiumfalciparum converts heme to bilirubin IXalpha in the apicoplastKen Okada
Research Center for Advanced Agrotechnology and Biotechnology, Toyohashi University of Technology, 1 1 Hibarigaoka, Tempaku cho, Toyohashi, Aichi 441 8580, Japan
FEBS Lett 583:313-9. 2009..In addition, PfHO required an iron chelator such as deferoxamine for complete activity. These observations lead to the conclusion that a novel enzymatic heme degradation system is present in human malaria parasites...
- Natural selection maintains a stable polymorphism at the circumsporozoite protein locus of Plasmodium falciparum in a low endemic areaChaturong Putaporntip
Department of Parasitology, Faculty of Medicine, Molecular Biology of Malaria and Opportunistic Parasites Research Unit, Chulalongkorn University, Bangkok, Thailand
Infect Genet Evol 9:567-73. 2009....
- Association of molecular markers in Plasmodium falciparum crt and mdr1 with in vitro chloroquine resistance: a Philippine studyToshimitsu Hatabu
Gunma University School of Health Sciences, 3 39 15 Showa Machi, Maebashi 371 8514, Japan
Parasitol Int 58:166-70. 2009..The results of this study indicate that mutations in pfcrt and pfmdr1 are not predictive of in vitro CQ resistance in Philippine isolates and may therefore not be suitable as molecular markers for surveillance...
- Evidence for catalytic roles for Plasmodium falciparum aminopeptidase P in the food vacuole and cytosolDaniel Ragheb
Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
J Biol Chem 284:24806-15. 2009..These results provide support for roles for PfAPP in peptide catabolism in both the food vacuole and the cytosol and suggest that PfAPP has evolved a dual distribution in response to the metabolic needs of the intraerythrocytic parasite...
- Identifying merozoite surface protein 4 and merozoite surface protein 7 Plasmodium falciparum protein family members specifically binding to human erythrocytes suggests a new malarial parasite-redundant survival mechanismYesid Garcia
Fundacion Instituto de Inmunologia de Colombia, Carrera 50 No 26 00, CP 020304, Bogota D C, Colombia, South America
J Med Chem 50:5665-75. 2007....
- Differential selective pressures on the merozoite surface protein 2 locus of Plasmodium falciparum in a low endemic areaChaturong Putaporntip
Molecular Biology of Malaria and Opportunistic Parasites Research Unit, Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
Gene 427:51-7. 2008..falciparum population in Thailand as a result of effective control measures that have sharply reduced the incidence of malaria infection...
- A polymorphic drug pump in the malaria parasiteKevin J Saliba
Biochemistry and Molecular Biology, School of Biology, The Australian National University, Canberra, ACT 0200, Australia
Mol Microbiol 70:775-9. 2008..The work provides important new insights into the mechanism by which Pgh1 influences malaria parasite drug sensitivity...
- Functional dissection of the catalytic carboxyl-terminal domain of origin recognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodium falciparumAshish Gupta
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India
Eukaryot Cell 8:1341-51. 2009..These results not only provide us a useful system to study the function of the essential genes in Plasmodium, they help us to identify the previously undiscovered unique features of replication proteins in general...
- Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shockMelissa Botha
Biomedical Biotechnology Research Unit, Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown, South Africa
Cell Stress Chaperones 16:389-401. 2011....
- Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodiesAnna Olivieri
Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom
PLoS Pathog 7:e1002448. 2011..Drugs that inhibit PfSUB2 activity should block parasite replication and may also enhance the efficacy of vaccines based on AMA1 and other merozoite surface proteins...
- Genetic polymorphism of merozoite surface protein 2 and prevalence of K76T pfcrt mutation in Plasmodium falciparum field isolates from Congolese children with asymptomatic infectionsFelix Koukouikila-Koussounda
Congolese Foundation for Medical Research, Brazzaville, Republic of Congo
Malar J 11:105. 2012..The prevalence of mutant P. falciparum chloroquine resistance transporter (pfcrt) allele in isolates was also determined...
- Plasmodium falciparum protein associated with the invasion junction contains a conserved oxidoreductase domainD E Hudson-Taylor
Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Microbiol 15:463-71. 1995..By virtue of its positive charge, the C-terminal domain resembles domains in some cytoskeleton-associated proteins and may mediate the interaction of MCP-1 with cytoskeleton in Plasmodium...
- Identification and localization of ERD2 in the malaria parasite Plasmodium falciparum: separation from sites of sphingomyelin synthesis and implications for organization of the GolgiH G Elmendorf
Department of Microbiology and Immunology, Stanford University School of Medicine 94305 5402
EMBO J 12:4763-73. 1993..Within the parasite it again localizes to a perinuclear region but does not reorganize upon BFA treatment. The results strongly suggest that these two activities are in distinct compartments of the Golgi in the malaria parasite...
- The MTIP-myosin A complex in blood stage malaria parasitesJudith L Green
Division of Parasitology, MRC National Institute for Medical Research, London NW7 1AA, UK
J Mol Biol 355:933-41. 2006..C-MyoA peptidomimetic compounds that disrupt the MTIP-myosin A interaction are predicted to inhibit parasite motility and host cell invasion, which may be targets for new therapeutic approaches...
- Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuoleShoba Subramanian
Department of Medicine, Division of Infectious Disease, University of California, San Francisco, San Francisco, California 94143, USA
J Biol Chem 282:24961-9. 2007....
- Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of responseKwadwo A Kusi
Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
PLoS ONE 5:e15391. 2010..Our data confirms the feasibility and potential of multi-allele PfAMA1 formulations, and highlights the need for adjuvants with improved antibody potentiation properties for AMA1-based vaccines...
- A family of chimeric erythrocyte binding proteins of malaria parasitesS H Kappe
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 5645, USA
Proc Natl Acad Sci U S A 95:1230-5. 1998..We propose that MAEBL is a member of a highly conserved family of erythrocyte binding proteins of Plasmodium involved in host cell invasion...
- Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparumD J Carucci
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
J Biol Chem 275:22147-56. 2000..The profound structural differences identified between mammalian and parasite guanylyl cyclases suggest that aspects of this signaling pathway may be mechanistically distinct...
- The 22 kDa component of the protein complex on the surface of Plasmodium falciparum merozoites is derived from a larger precursor, merozoite surface protein 7J A Pachebat
Division of Parasitology, National Institute for Medical Research, Mill Hill, NW7 1AA, London, UK
Mol Biochem Parasitol 117:83-9. 2001..A related gene was identified and cloned from the rodent malaria parasite, Plasmodium yoelii YM; at the amino acid level this sequence was 23% identical and 50% similar to that of P. falciparum MSP7...
- Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocketTao Bai
University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 102:12736-41. 2005..Precedents set by viral receptor proteins would suggest that this is likely to be the AMA1 receptor binding pocket...
- The role of KAHRP domains in knob formation and cytoadherence of P falciparum-infected human erythrocytesMelanie Rug
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Blood 108:370-8. 2006..We propose that the 5' repeat region of KAHRP is important in cross-linking to the host-cell cytoskeleton and this is required for knob protrusion and efficient adhesion under physiologic flow conditions...
- Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial proteaseStephanie X Wang
Department of Pathology and the Sandler Center, San Francisco General Hospital, University of California, CA 94143, USA
Proc Natl Acad Sci U S A 103:11503-8. 2006..Motifs similar to FP2(nose) and FP2(arm) are found only in related plasmodial proteases, suggesting that they confer malaria-specific functions...
- Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologueDamien V Cordery
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
J Infect Dis 195:905-12. 2007..The identification of a parasite homologue of MIF raised the question of whether it affects monocyte function in a manner similar to its human counterpart...
- Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in Plasmodium falciparumCecilia P Sanchez
Hygiene Institut, Abteilung Parasitologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
Mol Microbiol 70:786-98. 2008..falciparum digestive vacuole, and that this contributes to accumulation of, and susceptibility to, the drug in question...
- CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expressionPamela A Magistrado
Centre for Medical Parasitology at the Institute of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
Malar J 7:204. 2008..Also, unlike var genes from groups B and C, those from group A do not have sequences consistent with CD36 binding--a major cytoadhesion phenotype of P. falciparum isolates...
- Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoitesJun Cao
Department of Molecular Parasitology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
Parasitol Int 58:29-35. 2009..This evidence suggests that RON2 appears to have a fundamental role in host cell invasion by apicomplexan parasites, and is a potential target for malaria intervention strategies...
- Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparumZoe Holland
INSERM U609, Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, Scotland, United Kingdom
Eukaryot Cell 8:388-97. 2009..falciparum CK2alpha enzymes to a small molecule inhibitor. Taken together, our data identify PfCK2alpha as a potential target for antimalarial chemotherapeutic intervention...
- Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparumAlexander G Maier
The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
Infect Immun 77:1689-99. 2009..Combined, these data highlight the importance of sequence variability in EBAs as driven by immune selection but not by receptor specificity...
- Genetic polymorphism in msp-2, ama-1 and csp genes in Plasmodium falciparum field isolates from north and north-western IndiaUmar Farooq
Department of Parasitology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
J Vector Borne Dis 46:109-16. 2009..The aim of this study was to detect extent of genetic polymorphism in potential vaccine candidate antigen genes, i.e. msp-2, ama-1 and csp of P. falciparum isolates prevalent in northern and north-western parts of India...
- Small variant STEVOR antigen is uniquely located within Maurer's clefts in Plasmodium falciparum-infected red blood cellsM Kaviratne
Division of Parasitology, National Institute for Medical Research, London, United Kingdom
Eukaryot Cell 1:926-35. 2002..The fact that the timing of stevor expression and the location of STEVOR are clearly distinct from those of other parasite variant antigens suggests that this gene family may have a novel role in P. falciparum biology...
- Trafficking of the major virulence factor to the surface of transfected P. falciparum-infected erythrocytesEllen Knuepfer
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, 3050 Australia
Blood 105:4078-87. 2005..This study identifies the sequences required for expression of proteins to the outside of the P. falciparum-infected RBC membrane...
- Domain III of Plasmodium falciparum apical membrane antigen 1 binds to the erythrocyte membrane protein KxKentaro Kato
Laboratory of Malaria and Vector Research and Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
Proc Natl Acad Sci U S A 102:5552-7. 2005....
- Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complexOsamu Kaneko
Department of Molecular Parasitology, Ehime University School of Medicine, Toon, Shigenobu cho, Ehime 791 0295, Japan
Mol Biochem Parasitol 143:20-8. 2005..Since the PfRhopH complex binds the erythrocyte surface, and RhopH2 and RhopH3 are encoded by single copy genes, the RhopH1/Clag proteins may serve to confer some degree of specificity to the roles of the individual complexes...
- Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytesJanine Stubbs
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Science 309:1384-7. 2005..Differential activation of PfRh4 represents a previously unknown mechanism to switch invasion pathways and provides P. falciparum with exquisite adaptability in the face of erythrocyte receptor polymorphisms and host immune responses...
- Plasmodium falciparum AMA1 binds a rhoptry neck protein homologous to TgRON4, a component of the moving junction in Toxoplasma gondiiDavid L Alexander
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305 5124, USA
Eukaryot Cell 5:1169-73. 2006..PfRON4 also originates in the rhoptry necks, suggesting that this unusual collaboration of micronemes and rhoptries is a conserved feature of Apicomplexa...
- pfmdr2 confers heavy metal resistance to Plasmodium falciparumElli Rosenberg
Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel
J Biol Chem 281:27039-45. 2006..In contrast, the resistant line harbors a full-length, active protein. These findings strongly suggest that the PFMDR2 protein acts as an efflux pump of heavy metals...
- Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surfaceAlexander G Maier
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Blood 109:1289-97. 2007..Furthermore, the major reactivity of antibodies from malaria-exposed multigravid women is directed toward PfEMP1 because this is abolished in the absence of PfSBP1...
- Plasmodium falciparum merozoite surface protein 3 is a target of allele-specific immunity and alleles are maintained by natural selectionSpencer D Polley
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
J Infect Dis 195:279-87. 2007..Sequence polymorphisms divide alleles into 2 major types, but the adaptive and immunological significance of the types has not been defined...
- Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from SenegalCameron V Jennings
Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Infect Immun 75:3531-8. 2007....
- Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasionAlfred Cortes
Division of Parasitology, Medical Research Council National Institute for Medical Research NIMR, London, United Kingdom
PLoS Pathog 3:e107. 2007..Clonal variant expression of invasion-related ligands increases the flexibility of the parasite to adapt to its human host...
- Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion processMoritz Treeck
Department of Molecular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
PLoS Pathog 5:e1000322. 2009..We show that the cytoplasmic domain of AMA-1 is phosphorylated. Mutational analysis suggests an important role for the phosphorylation in the invasion process, which might translate into novel therapeutic strategies...
- Ectopic recombination of a malaria var gene during mitosis associated with an altered var switch rateMichael F Duffy
Department of Medicine at RMH, University of Melbourne, Parkville 3050, Australia
J Mol Biol 389:453-69. 2009....
- A MAP kinase homologue from the human malaria parasite, Plasmodium falciparumC M Doerig
Unité INSERM 399, Faculte de Medecine de Marseille, France
Gene 177:1-6. 1996..Pfmap-1 is located on chromosome 14 of P.falciparum, and its mRNA has a size of 3.7 kb...
- A central role for P48/45 in malaria parasite male gamete fertilityM R van Dijk
Laboratory for Parasitology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Cell 104:153-64. 2001..Unexpectedly, only male gamete fertility of p48/45- parasites was affected, failing to penetrate otherwise fertile female gametes. P48/45 is shown to be a surface protein of malaria parasites with a demonstrable role in fertilization...
- Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasionA Craig
Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK
Mol Biochem Parasitol 115:129-43. 2001..This review provides a summary of the molecules involved in cytoadherence and antigenic variation in P. falciparum...
- Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparumNorman C Waters
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910 5100, USA
Mol Biochem Parasitol 123:85-94. 2002..During the schizont stage of parasite development, there is a significant up-regulation of the mRNAs corresponding to these proteins, indicating an important metabolic requirement for fatty acids during this stage...
- A multigene family that interacts with the amino terminus of plasmodium MSP-1 identified using the yeast two-hybrid systemKerrianne Mello
Division of Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
Eukaryot Cell 1:915-25. 2002..In vitro binding experiments confirmed the interaction between MSRP-1, MSRP-2, and the amino-terminal region of P. falciparum MSP-1...
- Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryotePauline Ward
Wellcome Centre for Molecular Parasitology, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, Scotland, UK
BMC Genomics 5:79. 2004..We report an exhaustive analysis of the P. falciparum genomic database (PlasmoDB) aimed at identifying and classifying all ePKs in this organism...
- Analysis of the vitamin B6 biosynthesis pathway in the human malaria parasite Plasmodium falciparumCarsten Wrenger
Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
J Biol Chem 280:5242-8. 2005..The occurrence of the vitamin B6 de novo synthesis pathway displays a potential new drug target, which can be exploited for the development of new chemotherapeutics against the human malaria parasite P. falciparum...
- Characterisation of two novel proteins from the asexual stage of Plasmodium falciparum, H101 and H103J Andrew Pearce
Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3050, Australia
Mol Biochem Parasitol 139:141-51. 2005..This result may reflect redundancy in function among members of the MSP3/MSP6 gene family as has been described for other families of paralogue genes in P. falciparum...
- Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparumErica L Dahl
Department of Medicine, San Francisco General Hospital, University of California, Box 0811, San Francisco, CA 94143 0811, USA
Mol Biochem Parasitol 139:205-12. 2005..Our results support overlapping but not fully redundant roles for falcipain-2 and -3, which are targeted to the food vacuole and activated sequentially to degrade hemoglobin in erythrocytic parasites...
- Structural and functional studies of interaction between Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) and erythrocyte spectrinXinhong Pei
Red Cell Physiology Laboratory, New York Blood Center, New York, New York, 10021, USA
J Biol Chem 280:31166-71. 2005..As the presence of KAHRP at the erythrocyte membrane is necessary for cytoadherence in vivo, our findings have implications for the development of new therapies for mitigating the severity of malaria infection...
- Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparumJacqueline F Satchell
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Acta Crystallogr D Biol Crystallogr 61:1213-21. 2005....
- A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasitesJake Baum
Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
J Biol Chem 281:5197-208. 2006....
- Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active siteMark A Robien
Structural Genomics of Pathogenic Protozoa SGPP, Department of Biochemistry, University of Washington, Seattle 98195, USA
Proteins 62:570-7. 2006..This putative AEBSF molecule is positioned in a crucial location and hence our structure, with expected and unexpected ligands bound, can be of assistance in lead development and design of novel antimalarials...
- Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparumPaul R Gilson
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
Mol Cell Proteomics 5:1286-99. 2006..Together this work identified 11 and predicted a further 19 GPI-anchored proteins in P. falciparum...
- Interactions between merozoite surface proteins 1, 6, and 7 of the malaria parasite Plasmodium falciparumChristian W Kauth
Zentrum fuer Molekulare Biologie der Universitaet Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
J Biol Chem 281:31517-27. 2006....
- The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparumTania F de Koning-Ward
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
Mol Microbiol 67:278-90. 2008..This reduced efficiency of emergence explains the significant defect in oocyst formation in mosquitoes fed blood meals containing Pfg377-negative gametocytes, resulting in an almost complete blockade of infection...
- MSP1(19) miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface traffickingPaul R Gilson
The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3050, Australia
Mol Microbiol 68:124-38. 2008..Using a line expressing a green fluorescent protein-MSP1 fusion protein, we demonstrate that one mode of inhibition by antibodies targeting the MSP1(19) domain is the rapid agglutinating of merozoites prior to erythrocyte attachment...
- Alveolins, a new family of cortical proteins that define the protist infrakingdom AlveolataSven B Gould
School of Botany, University of Melbourne, Victoria, Australia
Mol Biol Evol 25:1219-30. 2008..They provide an excellent opportunity to explore the exceptional compartment that was apparently the key to a remarkable diversification of unique protists that occupy a wide array of lifestyle niches...
- Association of pfcrt but not pfmdr1 alleles with chloroquine resistance in Iranian isolates of Plasmodium falciparumSedigheh Zakeri
Malaria and Vector Research Group, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
Am J Trop Med Hyg 78:633-40. 2008..falciparum mutations associated with resistance to CQ are abundant in south-eastern Iran and this finding strongly supports that CQ as the first line drug is inadequate for treatment of uncomplicated falciparum malaria in Iran...
- Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesisCathy J Taylor
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
Mol Microbiol 69:110-8. 2008..The data indicate that PfPDEdelta plays a crucial role in regulating cGMP levels during sexual development...
- Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analysesAnna C van Brummelen
Department of Biochemistry, University of Pretoria, Pretoria, Gauteng 0002, South Africa
J Biol Chem 284:4635-46. 2009..In contrast with previous reports, the results provide evidence that P. falciparum responds to alleviate the detrimental effects of polyamine depletion via regulation of its transcriptome and subsequently the proteome and metabolome...
- Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membraneReginald A Kavishe
Department of Pharmacology and Toxicology 149, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
Malar J 8:205. 2009..In order to understand the molecular mechanisms underlying drug resistance, characterization of these transporters is essential. The aim of this study was to characterize and localize putative ABC transporters...
- Differential, positional-dependent transcriptional response of antigenic variation (var) genes to biological stress in Plasmodium falciparumElli Rosenberg
The Shraga Segal Department of Microbiology and Immunology, Ben Gurion University of Negev, Beer Sheva, Israel
PLoS ONE 4:e6991. 2009..As disease severity is partly associated with expression of particular var gene subtypes, manipulation of the IE environment may serve as a mechanism to direct transcription towards less virulent genes...
- MAHRP2, an exported protein of Plasmodium falciparum, is an essential component of Maurer's cleft tethersEsther Pachlatko
Swiss Tropical and Public Health Institute, Basel, Switzerland
Mol Microbiol 77:1136-52. 2010..Solubilization studies showed that MAHRP2 is membrane associated but not membrane spanning. Several attempts to delete the mahrp2 gene failed, indicating that the protein is essential for parasite survival...
- Validation of isoleucine utilization targets in Plasmodium falciparumEva S Istvan
Department of Medicine and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 108:1627-32. 2011..This approach is generally useful for elucidation of new targets in P. falciparum. Our study shows that isoleucine utilization is an essential pathway that can be targeted for antimalarial drug development...
- The cysteine-rich regions of Plasmodium falciparum RON2 bind with host erythrocyte and AMA1 during merozoite invasionMohammad E Hossain
International Centre for Genetic Engineering and Biotechnology, New Delhi, 110 067, India
Parasitol Res 110:1711-21. 2012..These results suggest that PfRON2 plays a role in merozoite invasion and thus it can be an important vaccine candidate antigen...
- Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discoveryStephan Meister
Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
Science 334:1372-7. 2011..The open-source chemical tools resulting from our effort provide starting points for future drug discovery programs, as well as opportunities for researchers to investigate the biology of exo-erythrocytic forms...
- Plasmodium falciparum centromeres display a unique epigenetic makeup and cluster prior to and during schizogonyWieteke A M Hoeijmakers
Department of Molecular Biology, Radboud University, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
Cell Microbiol 14:1391-401. 2012..These findings suggest that DNA-associated and epigenetic elements play an important role in centromere establishment in this important human pathogen...
- Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasitesEric Salazar
Tri Institutional MD PhD Program, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, New York, United States of America
PLoS ONE 7:e39769. 2012..One particular inhibitor is selective for PfACβ relative to its human ortholog, soluble adenylyl cyclase (sAC); thus, PfACβ represents a potential target for development of safe and effective antimalarial therapeutics...
- Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapyAline Fréville
Center for Infection and Immunity of Lille, INSERM U1019 CNRS UMR 8204, University of Lille Nord de France, Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019 Lille, Cedex, France
BMC Biol 11:80. 2013..Among these, inhibitor-2 (I2) is one of the most evolutionarily ancient PP1 regulators. In vivo studies in various organisms revealed a defect in chromosome segregation and cell cycle progression when the function of I2 is blocked...
- A new blood stage antigen of Plasmodium falciparum transported to the erythrocyte surfaceB Knapp
Department of Molecular Biology, Behringwerke AG, Marburg, F R G
Mol Biochem Parasitol 37:47-56. 1989..The 41-2 protein could be localized in the schizont membrane, associated with membranous structures in the erythrocytic cytoplasm and with the erythrocyte membrane...
- Merozoite surface protein 8 of Plasmodium falciparum contains two epidermal growth factor-like domainsC G Black
Department of Microbiology, PO Box 53, Monash University, 3800, Victoria, Australia
Mol Biochem Parasitol 114:217-26. 2001..suggesting that the two proteins are homologues. Taken together, these findings suggest that MSP8/pypAg-2 may play an important role in the process of red cell invasion and is a potential malaria vaccine candidate...
- Translational Control in Plasmodium Sexual DevelopmentLiwang Cui; Fiscal Year: 2005....
- Plasmodium vivax:Proteomic Analysis of Asexual and Sporozoite StagesLiwang Cui; Fiscal Year: 2007..Its recent resurgence in prevalence and emergence of drug- resistant parasite strains have raised a great concern for the future control of malaria. [unreadable] [unreadable] [unreadable]..
- Development of a cell-based method for high-throughput drug screening in malaria Liwang Cui; Fiscal Year: 2008..To facilitate antimalarial drug discovery, we propose to develop a highly sensitive, cell-based, one-step luminescent drug screen assay for high throughput screening of large chemical libraries. [unreadable] [unreadable] [unreadable]..
- Proteomic analysis of the T. gondii vacuolar membraneAnthony Sinai; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Blockade of host apoptosis by Toxoplasma gondiiAnthony P Sinai; Fiscal Year: 2010..Dissection of these pathways is particularly important given the targets of NFKB many of the cytokines implicated both in the pathogenesis of acute toxoplasmosis and the development of immunity to the parasite. ..
- A Tetravalent Dengue Recombinanat Protein VaccineB Sim; Fiscal Year: 2005..abstract_text> ..
- A SARS-CoV Spike Protein VaccineB Sim; Fiscal Year: 2005..abstract_text> ..
- Plasmodium vivax recombinant CS protein vaccineB Sim; Fiscal Year: 2006..abstract_text> ..
- Inhibition of Alzheimer's Beta-Amyloid Fibril FormationDuy Hua; Fiscal Year: 2009..However, soluble oligomeric Abeta showed high neuronal toxicity. Inhibition of the formation of these toxic soluble Abeta oligomers would provide therapeutics for AD. ..
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