Plasmodium falciparum 3D7

Summary

Alias: Plasmodium falciparum (isolate 3D7), PLASMODIUM FALCIPARUM (ISOLATE 3D7).

Top Publications

  1. pmc In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
    Christin Sisowath
    Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 199:750-7. 2009
  2. ncbi In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)
    Christin Sisowath
    Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Infect Dis 191:1014-7. 2005
  3. pmc Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum
    Christopher J Tonkin
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    PLoS Biol 7:e84. 2009
  4. pmc A multifunctional serine protease primes the malaria parasite for red blood cell invasion
    Konstantinos Koussis
    Division of Parasitology, National Institute for Medical Research, London, UK
    EMBO J 28:725-35. 2009
  5. ncbi P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
    J A Rowe
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 388:292-5. 1997
  6. pmc The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase
    Judith L Green
    Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Biol Chem 283:30980-9. 2008
  7. pmc H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3
    Richard Bartfai
    Department of Molecular Biology, Radboud University, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    PLoS Pathog 6:e1001223. 2010
  8. pmc Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum
    Stephanie G Valderramos
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America
    PLoS Pathog 6:e1000887. 2010
  9. ncbi Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites
    Lucio H Freitas-Junior
    Institut Pasteur, Biology of Host Parasite Interactions Unit CNRS URA2581, 25, rue du Dr Roux, 75724 Paris, France
    Cell 121:25-36. 2005
  10. pmc Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth
    Matthew A Child
    Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Mol Microbiol 78:187-202. 2010

Patents

  1. A PROCESS FOR ENGINEERING NUCLEOTIDE SPECIFICITY
  2. Vaccine composition against malaria
  3. Recombinant plasmodium falciparum merozoite protein-1/42 vaccine
  4. Isolation and purification of p. Falciparum merozoite protein-1 42? vaccine
  5. Baculoviral vectors with a dual vertebrate and baculovirus promoter controlling an immunogenic fusion gene
  6. Process for the production of fine chemicals
  7. Process for the production of lutein
  8. Process for the production of fine chemicals
  9. Process for the control of production of fine chemicals
  10. Proteins associated with abiotic stress response and homologs

Detail Information

Publications210 found, 100 shown here

  1. pmc In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
    Christin Sisowath
    Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 199:750-7. 2009
    ..Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for the detection and surveillance of AL resistance...
  2. ncbi In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)
    Christin Sisowath
    Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Infect Dis 191:1014-7. 2005
    ..This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings...
  3. pmc Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum
    Christopher J Tonkin
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    PLoS Biol 7:e84. 2009
    ..This work highlights the pivotal but distinct role for both PfSir2 paralogues in epigenetic silencing of P. falciparum virulence genes and the control of pathogenicity of malaria infection...
  4. pmc A multifunctional serine protease primes the malaria parasite for red blood cell invasion
    Konstantinos Koussis
    Division of Parasitology, National Institute for Medical Research, London, UK
    EMBO J 28:725-35. 2009
    ..We propose that PfSUB1 is a multifunctional processing protease with an essential role in both egress of the malaria merozoite and remodelling of its surface in preparation for erythrocyte invasion...
  5. ncbi P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
    J A Rowe
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 388:292-5. 1997
    ..Thus we describe a new adhesive function for PfEMP1 and raise the possibility that CR1 polymorphisms in Africans that influence the interaction between erythrocytes and PfEMP1 may protect against severe malaria...
  6. pmc The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase
    Judith L Green
    Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Biol Chem 283:30980-9. 2008
    ..Both CDPK1 activity and host cell invasion can be inhibited by the kinase inhibitor K252a, suggesting that CDPK1 is a suitable target for antimalarial drug development...
  7. pmc H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3
    Richard Bartfai
    Department of Molecular Biology, Radboud University, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    PLoS Pathog 6:e1001223. 2010
    ..Furthermore, our findings place H2A.Z at the cradle of P. falciparum epigenetic regulation by stably defining intergenic regions and providing a platform for dynamic assembly of epigenetic and other transcription related complexes...
  8. pmc Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum
    Stephanie G Valderramos
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America
    PLoS Pathog 6:e1000887. 2010
    ....
  9. ncbi Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites
    Lucio H Freitas-Junior
    Institut Pasteur, Biology of Host Parasite Interactions Unit CNRS URA2581, 25, rue du Dr Roux, 75724 Paris, France
    Cell 121:25-36. 2005
    ..Our data demonstrate that mutually exclusive transcription of var genes is linked to the dynamic remodeling of chromatin...
  10. pmc Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth
    Matthew A Child
    Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Mol Microbiol 78:187-202. 2010
    ..Our findings show that correct spatiotemporal regulation of MSP1 maturation is crucial for the function of the protein and for maintenance of the parasite asexual blood-stage life cycle...
  11. ncbi Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum
    Puran S Sijwali
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, CA 94143 0811, USA
    Mol Biochem Parasitol 150:96-106. 2006
    ..Our data suggest key roles for falcipain-2 and falcipain-3 in the development of erythrocytic malaria parasites and a complex interplay between P. falciparum cysteine and aspartic proteases...
  12. pmc Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite
    Kerstin Leykauf
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    PLoS Pathog 6:e1000941. 2010
    ..In addition to shedding unexpected new light on AMA1 function, this work represents the first time PKA has been implicated in merozoite invasion...
  13. ncbi Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
    M B Reed
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Nature 403:906-9. 2000
    ..This has important implications for the development and efficacy of future antimalarial agents...
  14. pmc A conserved multi-gene family induces cross-reactive antibodies effective in defense against Plasmodium falciparum
    Subhash Singh
    Bio medical Parasitology Unit, Institut Pasteur, Paris, France
    PLoS ONE 4:e5410. 2009
    ..Both MSP3 and MSP6 share a common characteristic small N-terminal signature amino-acid stretch (NLRNA/G), a feature similar to MSP3-like orthologs identified in other human and primate malaria parasites...
  15. pmc Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum
    Marina Chavchich
    Australian Army Malaria Institute, Gallipoli Barracks, Enoggera, Australia
    Antimicrob Agents Chemother 54:2455-64. 2010
    ..This observation is of practical importance, because artemisinin drugs are often used in combination with mefloquine for the treatment of malaria...
  16. pmc Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease
    Natalie C Silmon de Monerri
    Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 79:1086-97. 2011
    ..Our findings imply multiple roles for PfSUB1 in the parasite life cycle, further supporting the case for considering the protease as a potential new antimalarial drug target...
  17. pmc Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway
    Eeshita G Dastidar
    Biology of Host Parasite Interactions Unit, Institut Pasteur, 25 rue du Dr Roux, F 75724 Paris, France
    BMC Biol 10:5. 2012
    ..The parasite's genome encodes one catalytic subunit, PfCK2α, which we have previously shown to be essential for completion of the asexual erythrocytic cycle, and two putative regulatory subunits, PfCK2β1 and PfCK2β2...
  18. pmc Tracking Glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum
    Jeffrey A Yeoman
    La Trobe University, Biochemistry Department, Bundoora, Australia
    Eukaryot Cell 10:556-64. 2011
    ..Replacement of the acid phosphatase homology domain of PfGAP50 with GFP appears to allow correct trafficking of the chimera but confers a growth disadvantage...
  19. pmc Analysis of the conformation and function of the Plasmodium falciparum merozoite proteins MTRAP and PTRAMP
    Onyinyechukwu Uchime
    Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    Eukaryot Cell 11:615-25. 2012
    ..MTRAP- and in general PTRAMP-specific antibodies failed to inhibit P. falciparum development in vitro. Altogether, MTRAP is a highly extended bifunctional protein that binds to an erythrocyte receptor and the merozoite motor...
  20. pmc Effects of calcium signaling on Plasmodium falciparum erythrocyte invasion and post-translational modification of gliding-associated protein 45 (PfGAP45)
    Matthew L Jones
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Biochem Parasitol 168:55-62. 2009
    ..falciparum erythrocyte invasion and reveals that the assembly status of the merozoite glideosome, which is central to erythrocyte invasion, is surprisingly dynamic...
  21. pmc Plasmodium falciparum reticulocyte binding-like homologue protein 2 (PfRH2) is a key adhesive molecule involved in erythrocyte invasion
    Tajali Sahar
    Malaria Group, International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi, India
    PLoS ONE 6:e17102. 2011
    ..PfRH2a/2b thus plays a key role in erythrocyte invasion and its conserved receptor-binding domain deserves attention as a promising candidate for inclusion in a blood-stage malaria vaccine...
  22. ncbi Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum
    K K Eggleson
    Howard Hughes Medical Institute, Washington University, Department of Molecular Microbiology, St Louis, Missouri 63110, USA
    J Biol Chem 274:32411-7. 1999
    ..The characterization of falcilysin increases our understanding of hemoglobin catabolism in P. falciparum and the unusual M16 family of metallopeptidases...
  23. doi Export of PfSBP1 to the Plasmodium falciparum Maurer's clefts
    Theodora Saridaki
    Hygiene Institut, Abteilung Parasitologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Traffic 10:137-52. 2009
    ..Our findings suggest new principles of protein export in P. falciparum-infected erythrocytes...
  24. ncbi Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:531-4. 2002
    ..We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome...
  25. doi Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa
    Sabina Dahlström
    Malaria Research, Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 200:1456-64. 2009
    ..Our data suggest for the first time, to our knowledge, the involvement of pfMRP1 in P. falciparum in vivo response to ACT...
  26. ncbi Hemoglobin metabolism in the malaria parasite Plasmodium falciparum
    S E Francis
    Howard Hughes Medical Institute, Department of Molecular Microbiology and Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Annu Rev Microbiol 51:97-123. 1997
    ..Understanding the disposition of hemoglobin has allowed identification of essential processes and metabolic weakpoints that can be exploited to combat this scourge of mankind...
  27. pmc Mosquito heparan sulfate and its potential role in malaria infection and transmission
    Photini Sinnis
    Department of Medical Parasitology, New York University School of Medicine, New York, New York 10010, USA
    J Biol Chem 282:25376-84. 2007
    ..The heparan sulfate isolated from the whole mosquito binds to circumsporozoite protein, suggesting a role within the mosquito for infection and transmission of the Plasmodium parasite...
  28. doi The novel heme oxygenase-like protein from Plasmodiumfalciparum converts heme to bilirubin IXalpha in the apicoplast
    Ken Okada
    Research Center for Advanced Agrotechnology and Biotechnology, Toyohashi University of Technology, 1 1 Hibarigaoka, Tempaku cho, Toyohashi, Aichi 441 8580, Japan
    FEBS Lett 583:313-9. 2009
    ..In addition, PfHO required an iron chelator such as deferoxamine for complete activity. These observations lead to the conclusion that a novel enzymatic heme degradation system is present in human malaria parasites...
  29. pmc Natural selection maintains a stable polymorphism at the circumsporozoite protein locus of Plasmodium falciparum in a low endemic area
    Chaturong Putaporntip
    Department of Parasitology, Faculty of Medicine, Molecular Biology of Malaria and Opportunistic Parasites Research Unit, Chulalongkorn University, Bangkok, Thailand
    Infect Genet Evol 9:567-73. 2009
    ....
  30. doi Association of molecular markers in Plasmodium falciparum crt and mdr1 with in vitro chloroquine resistance: a Philippine study
    Toshimitsu Hatabu
    Gunma University School of Health Sciences, 3 39 15 Showa Machi, Maebashi 371 8514, Japan
    Parasitol Int 58:166-70. 2009
    ..The results of this study indicate that mutations in pfcrt and pfmdr1 are not predictive of in vitro CQ resistance in Philippine isolates and may therefore not be suitable as molecular markers for surveillance...
  31. pmc Evidence for catalytic roles for Plasmodium falciparum aminopeptidase P in the food vacuole and cytosol
    Daniel Ragheb
    Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Biol Chem 284:24806-15. 2009
    ..These results provide support for roles for PfAPP in peptide catabolism in both the food vacuole and the cytosol and suggest that PfAPP has evolved a dual distribution in response to the metabolic needs of the intraerythrocytic parasite...
  32. ncbi Identifying merozoite surface protein 4 and merozoite surface protein 7 Plasmodium falciparum protein family members specifically binding to human erythrocytes suggests a new malarial parasite-redundant survival mechanism
    Yesid Garcia
    Fundacion Instituto de Inmunologia de Colombia, Carrera 50 No 26 00, CP 020304, Bogota D C, Colombia, South America
    J Med Chem 50:5665-75. 2007
    ....
  33. pmc Differential selective pressures on the merozoite surface protein 2 locus of Plasmodium falciparum in a low endemic area
    Chaturong Putaporntip
    Molecular Biology of Malaria and Opportunistic Parasites Research Unit, Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Gene 427:51-7. 2008
    ..falciparum population in Thailand as a result of effective control measures that have sharply reduced the incidence of malaria infection...
  34. doi A polymorphic drug pump in the malaria parasite
    Kevin J Saliba
    Biochemistry and Molecular Biology, School of Biology, The Australian National University, Canberra, ACT 0200, Australia
    Mol Microbiol 70:775-9. 2008
    ..The work provides important new insights into the mechanism by which Pgh1 influences malaria parasite drug sensitivity...
  35. pmc Functional dissection of the catalytic carboxyl-terminal domain of origin recognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodium falciparum
    Ashish Gupta
    Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India
    Eukaryot Cell 8:1341-51. 2009
    ..These results not only provide us a useful system to study the function of the essential genes in Plasmodium, they help us to identify the previously undiscovered unique features of replication proteins in general...
  36. pmc Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock
    Melissa Botha
    Biomedical Biotechnology Research Unit, Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown, South Africa
    Cell Stress Chaperones 16:389-401. 2011
    ....
  37. pmc Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies
    Anna Olivieri
    Division of Parasitology, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom
    PLoS Pathog 7:e1002448. 2011
    ..Drugs that inhibit PfSUB2 activity should block parasite replication and may also enhance the efficacy of vaccines based on AMA1 and other merozoite surface proteins...
  38. pmc Genetic polymorphism of merozoite surface protein 2 and prevalence of K76T pfcrt mutation in Plasmodium falciparum field isolates from Congolese children with asymptomatic infections
    Felix Koukouikila-Koussounda
    Congolese Foundation for Medical Research, Brazzaville, Republic of Congo
    Malar J 11:105. 2012
    ..The prevalence of mutant P. falciparum chloroquine resistance transporter (pfcrt) allele in isolates was also determined...
  39. ncbi Plasmodium falciparum protein associated with the invasion junction contains a conserved oxidoreductase domain
    D E Hudson-Taylor
    Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Microbiol 15:463-71. 1995
    ..By virtue of its positive charge, the C-terminal domain resembles domains in some cytoskeleton-associated proteins and may mediate the interaction of MCP-1 with cytoskeleton in Plasmodium...
  40. pmc Identification and localization of ERD2 in the malaria parasite Plasmodium falciparum: separation from sites of sphingomyelin synthesis and implications for organization of the Golgi
    H G Elmendorf
    Department of Microbiology and Immunology, Stanford University School of Medicine 94305 5402
    EMBO J 12:4763-73. 1993
    ..Within the parasite it again localizes to a perinuclear region but does not reorganize upon BFA treatment. The results strongly suggest that these two activities are in distinct compartments of the Golgi in the malaria parasite...
  41. ncbi The MTIP-myosin A complex in blood stage malaria parasites
    Judith L Green
    Division of Parasitology, MRC National Institute for Medical Research, London NW7 1AA, UK
    J Mol Biol 355:933-41. 2006
    ..C-MyoA peptidomimetic compounds that disrupt the MTIP-myosin A interaction are predicted to inhibit parasite motility and host cell invasion, which may be targets for new therapeutic approaches...
  42. ncbi Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole
    Shoba Subramanian
    Department of Medicine, Division of Infectious Disease, University of California, San Francisco, San Francisco, California 94143, USA
    J Biol Chem 282:24961-9. 2007
    ....
  43. pmc Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response
    Kwadwo A Kusi
    Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    PLoS ONE 5:e15391. 2010
    ..Our data confirms the feasibility and potential of multi-allele PfAMA1 formulations, and highlights the need for adjuvants with improved antibody potentiation properties for AMA1-based vaccines...
  44. pmc A family of chimeric erythrocyte binding proteins of malaria parasites
    S H Kappe
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 5645, USA
    Proc Natl Acad Sci U S A 95:1230-5. 1998
    ..We propose that MAEBL is a member of a highly conserved family of erythrocyte binding proteins of Plasmodium involved in host cell invasion...
  45. ncbi Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum
    D J Carucci
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    J Biol Chem 275:22147-56. 2000
    ..The profound structural differences identified between mammalian and parasite guanylyl cyclases suggest that aspects of this signaling pathway may be mechanistically distinct...
  46. ncbi The 22 kDa component of the protein complex on the surface of Plasmodium falciparum merozoites is derived from a larger precursor, merozoite surface protein 7
    J A Pachebat
    Division of Parasitology, National Institute for Medical Research, Mill Hill, NW7 1AA, London, UK
    Mol Biochem Parasitol 117:83-9. 2001
    ..A related gene was identified and cloned from the rodent malaria parasite, Plasmodium yoelii YM; at the amino acid level this sequence was 23% identical and 50% similar to that of P. falciparum MSP7...
  47. pmc Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket
    Tao Bai
    University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 102:12736-41. 2005
    ..Precedents set by viral receptor proteins would suggest that this is likely to be the AMA1 receptor binding pocket...
  48. pmc The role of KAHRP domains in knob formation and cytoadherence of P falciparum-infected human erythrocytes
    Melanie Rug
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 108:370-8. 2006
    ..We propose that the 5' repeat region of KAHRP is important in cross-linking to the host-cell cytoskeleton and this is required for knob protrusion and efficient adhesion under physiologic flow conditions...
  49. pmc Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease
    Stephanie X Wang
    Department of Pathology and the Sandler Center, San Francisco General Hospital, University of California, CA 94143, USA
    Proc Natl Acad Sci U S A 103:11503-8. 2006
    ..Motifs similar to FP2(nose) and FP2(arm) are found only in related plasmodial proteases, suggesting that they confer malaria-specific functions...
  50. pmc Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologue
    Damien V Cordery
    Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    J Infect Dis 195:905-12. 2007
    ..The identification of a parasite homologue of MIF raised the question of whether it affects monocyte function in a manner similar to its human counterpart...
  51. doi Polymorphisms within PfMDR1 alter the substrate specificity for anti-malarial drugs in Plasmodium falciparum
    Cecilia P Sanchez
    Hygiene Institut, Abteilung Parasitologie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Mol Microbiol 70:786-98. 2008
    ..falciparum digestive vacuole, and that this contributes to accumulation of, and susceptibility to, the drug in question...
  52. pmc CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expression
    Pamela A Magistrado
    Centre for Medical Parasitology at the Institute of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Malar J 7:204. 2008
    ..Also, unlike var genes from groups B and C, those from group A do not have sequences consistent with CD36 binding--a major cytoadhesion phenotype of P. falciparum isolates...
  53. doi Rhoptry neck protein RON2 forms a complex with microneme protein AMA1 in Plasmodium falciparum merozoites
    Jun Cao
    Department of Molecular Parasitology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Parasitol Int 58:29-35. 2009
    ..This evidence suggests that RON2 appears to have a fundamental role in host cell invasion by apicomplexan parasites, and is a potential target for malaria intervention strategies...
  54. pmc Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum
    Zoe Holland
    INSERM U609, Wellcome Centre for Molecular Parasitology, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, Scotland, United Kingdom
    Eukaryot Cell 8:388-97. 2009
    ..falciparum CK2alpha enzymes to a small molecule inhibitor. Taken together, our data identify PfCK2alpha as a potential target for antimalarial chemotherapeutic intervention...
  55. pmc Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum
    Alexander G Maier
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Infect Immun 77:1689-99. 2009
    ..Combined, these data highlight the importance of sequence variability in EBAs as driven by immune selection but not by receptor specificity...
  56. ncbi Genetic polymorphism in msp-2, ama-1 and csp genes in Plasmodium falciparum field isolates from north and north-western India
    Umar Farooq
    Department of Parasitology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    J Vector Borne Dis 46:109-16. 2009
    ..The aim of this study was to detect extent of genetic polymorphism in potential vaccine candidate antigen genes, i.e. msp-2, ama-1 and csp of P. falciparum isolates prevalent in northern and north-western parts of India...
  57. pmc Small variant STEVOR antigen is uniquely located within Maurer's clefts in Plasmodium falciparum-infected red blood cells
    M Kaviratne
    Division of Parasitology, National Institute for Medical Research, London, United Kingdom
    Eukaryot Cell 1:926-35. 2002
    ..The fact that the timing of stevor expression and the location of STEVOR are clearly distinct from those of other parasite variant antigens suggests that this gene family may have a novel role in P. falciparum biology...
  58. pmc Trafficking of the major virulence factor to the surface of transfected P. falciparum-infected erythrocytes
    Ellen Knuepfer
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, 3050 Australia
    Blood 105:4078-87. 2005
    ..This study identifies the sequences required for expression of proteins to the outside of the P. falciparum-infected RBC membrane...
  59. pmc Domain III of Plasmodium falciparum apical membrane antigen 1 binds to the erythrocyte membrane protein Kx
    Kentaro Kato
    Laboratory of Malaria and Vector Research and Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    Proc Natl Acad Sci U S A 102:5552-7. 2005
    ....
  60. ncbi Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex
    Osamu Kaneko
    Department of Molecular Parasitology, Ehime University School of Medicine, Toon, Shigenobu cho, Ehime 791 0295, Japan
    Mol Biochem Parasitol 143:20-8. 2005
    ..Since the PfRhopH complex binds the erythrocyte surface, and RhopH2 and RhopH3 are encoded by single copy genes, the RhopH1/Clag proteins may serve to confer some degree of specificity to the roles of the individual complexes...
  61. ncbi Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes
    Janine Stubbs
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 309:1384-7. 2005
    ..Differential activation of PfRh4 represents a previously unknown mechanism to switch invasion pathways and provides P. falciparum with exquisite adaptability in the face of erythrocyte receptor polymorphisms and host immune responses...
  62. pmc Plasmodium falciparum AMA1 binds a rhoptry neck protein homologous to TgRON4, a component of the moving junction in Toxoplasma gondii
    David L Alexander
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305 5124, USA
    Eukaryot Cell 5:1169-73. 2006
    ..PfRON4 also originates in the rhoptry necks, suggesting that this unusual collaboration of micronemes and rhoptries is a conserved feature of Apicomplexa...
  63. ncbi pfmdr2 confers heavy metal resistance to Plasmodium falciparum
    Elli Rosenberg
    Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel
    J Biol Chem 281:27039-45. 2006
    ..In contrast, the resistant line harbors a full-length, active protein. These findings strongly suggest that the PFMDR2 protein acts as an efflux pump of heavy metals...
  64. pmc Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface
    Alexander G Maier
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Blood 109:1289-97. 2007
    ..Furthermore, the major reactivity of antibodies from malaria-exposed multigravid women is directed toward PfEMP1 because this is abolished in the absence of PfSBP1...
  65. ncbi Plasmodium falciparum merozoite surface protein 3 is a target of allele-specific immunity and alleles are maintained by natural selection
    Spencer D Polley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 195:279-87. 2007
    ..Sequence polymorphisms divide alleles into 2 major types, but the adaptive and immunological significance of the types has not been defined...
  66. pmc Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal
    Cameron V Jennings
    Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Infect Immun 75:3531-8. 2007
    ....
  67. pmc Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion
    Alfred Cortes
    Division of Parasitology, Medical Research Council National Institute for Medical Research NIMR, London, United Kingdom
    PLoS Pathog 3:e107. 2007
    ..Clonal variant expression of invasion-related ligands increases the flexibility of the parasite to adapt to its human host...
  68. pmc Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process
    Moritz Treeck
    Department of Molecular Parasitology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS Pathog 5:e1000322. 2009
    ..We show that the cytoplasmic domain of AMA-1 is phosphorylated. Mutational analysis suggests an important role for the phosphorylation in the invasion process, which might translate into novel therapeutic strategies...
  69. pmc Ectopic recombination of a malaria var gene during mitosis associated with an altered var switch rate
    Michael F Duffy
    Department of Medicine at RMH, University of Melbourne, Parkville 3050, Australia
    J Mol Biol 389:453-69. 2009
    ....
  70. ncbi A MAP kinase homologue from the human malaria parasite, Plasmodium falciparum
    C M Doerig
    Unité INSERM 399, Faculte de Medecine de Marseille, France
    Gene 177:1-6. 1996
    ..Pfmap-1 is located on chromosome 14 of P.falciparum, and its mRNA has a size of 3.7 kb...
  71. ncbi A central role for P48/45 in malaria parasite male gamete fertility
    M R van Dijk
    Laboratory for Parasitology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Cell 104:153-64. 2001
    ..Unexpectedly, only male gamete fertility of p48/45- parasites was affected, failing to penetrate otherwise fertile female gametes. P48/45 is shown to be a surface protein of malaria parasites with a demonstrable role in fertilization...
  72. ncbi Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion
    A Craig
    Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK
    Mol Biochem Parasitol 115:129-43. 2001
    ..This review provides a summary of the molecules involved in cytoadherence and antigenic variation in P. falciparum...
  73. ncbi Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum
    Norman C Waters
    Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910 5100, USA
    Mol Biochem Parasitol 123:85-94. 2002
    ..During the schizont stage of parasite development, there is a significant up-regulation of the mRNAs corresponding to these proteins, indicating an important metabolic requirement for fatty acids during this stage...
  74. pmc A multigene family that interacts with the amino terminus of plasmodium MSP-1 identified using the yeast two-hybrid system
    Kerrianne Mello
    Division of Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Eukaryot Cell 1:915-25. 2002
    ..In vitro binding experiments confirmed the interaction between MSRP-1, MSRP-2, and the amino-terminal region of P. falciparum MSP-1...
  75. pmc Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote
    Pauline Ward
    Wellcome Centre for Molecular Parasitology, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, Scotland, UK
    BMC Genomics 5:79. 2004
    ..We report an exhaustive analysis of the P. falciparum genomic database (PlasmoDB) aimed at identifying and classifying all ePKs in this organism...
  76. ncbi Analysis of the vitamin B6 biosynthesis pathway in the human malaria parasite Plasmodium falciparum
    Carsten Wrenger
    Department of Biochemistry, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    J Biol Chem 280:5242-8. 2005
    ..The occurrence of the vitamin B6 de novo synthesis pathway displays a potential new drug target, which can be exploited for the development of new chemotherapeutics against the human malaria parasite P. falciparum...
  77. ncbi Characterisation of two novel proteins from the asexual stage of Plasmodium falciparum, H101 and H103
    J Andrew Pearce
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC 3050, Australia
    Mol Biochem Parasitol 139:141-51. 2005
    ..This result may reflect redundancy in function among members of the MSP3/MSP6 gene family as has been described for other families of paralogue genes in P. falciparum...
  78. ncbi Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum
    Erica L Dahl
    Department of Medicine, San Francisco General Hospital, University of California, Box 0811, San Francisco, CA 94143 0811, USA
    Mol Biochem Parasitol 139:205-12. 2005
    ..Our results support overlapping but not fully redundant roles for falcipain-2 and -3, which are targeted to the food vacuole and activated sequentially to degrade hemoglobin in erythrocytic parasites...
  79. ncbi Structural and functional studies of interaction between Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) and erythrocyte spectrin
    Xinhong Pei
    Red Cell Physiology Laboratory, New York Blood Center, New York, New York, 10021, USA
    J Biol Chem 280:31166-71. 2005
    ..As the presence of KAHRP at the erythrocyte membrane is necessary for cytoadherence in vivo, our findings have implications for the development of new therapies for mitigating the severity of malaria infection...
  80. ncbi Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum
    Jacqueline F Satchell
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Acta Crystallogr D Biol Crystallogr 61:1213-21. 2005
    ....
  81. ncbi A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites
    Jake Baum
    Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Biol Chem 281:5197-208. 2006
    ....
  82. ncbi Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site
    Mark A Robien
    Structural Genomics of Pathogenic Protozoa SGPP, Department of Biochemistry, University of Washington, Seattle 98195, USA
    Proteins 62:570-7. 2006
    ..This putative AEBSF molecule is positioned in a crucial location and hence our structure, with expected and unexpected ligands bound, can be of assistance in lead development and design of novel antimalarials...
  83. ncbi Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum
    Paul R Gilson
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Mol Cell Proteomics 5:1286-99. 2006
    ..Together this work identified 11 and predicted a further 19 GPI-anchored proteins in P. falciparum...
  84. ncbi Interactions between merozoite surface proteins 1, 6, and 7 of the malaria parasite Plasmodium falciparum
    Christian W Kauth
    Zentrum fuer Molekulare Biologie der Universitaet Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    J Biol Chem 281:31517-27. 2006
    ....
  85. ncbi The role of osmiophilic bodies and Pfg377 expression in female gametocyte emergence and mosquito infectivity in the human malaria parasite Plasmodium falciparum
    Tania F de Koning-Ward
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Mol Microbiol 67:278-90. 2008
    ..This reduced efficiency of emergence explains the significant defect in oocyst formation in mosquitoes fed blood meals containing Pfg377-negative gametocytes, resulting in an almost complete blockade of infection...
  86. doi MSP1(19) miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface trafficking
    Paul R Gilson
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3050, Australia
    Mol Microbiol 68:124-38. 2008
    ..Using a line expressing a green fluorescent protein-MSP1 fusion protein, we demonstrate that one mode of inhibition by antibodies targeting the MSP1(19) domain is the rapid agglutinating of merozoites prior to erythrocyte attachment...
  87. doi Alveolins, a new family of cortical proteins that define the protist infrakingdom Alveolata
    Sven B Gould
    School of Botany, University of Melbourne, Victoria, Australia
    Mol Biol Evol 25:1219-30. 2008
    ..They provide an excellent opportunity to explore the exceptional compartment that was apparently the key to a remarkable diversification of unique protists that occupy a wide array of lifestyle niches...
  88. ncbi Association of pfcrt but not pfmdr1 alleles with chloroquine resistance in Iranian isolates of Plasmodium falciparum
    Sedigheh Zakeri
    Malaria and Vector Research Group, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
    Am J Trop Med Hyg 78:633-40. 2008
    ..falciparum mutations associated with resistance to CQ are abundant in south-eastern Iran and this finding strongly supports that CQ as the first line drug is inadequate for treatment of uncomplicated falciparum malaria in Iran...
  89. pmc Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis
    Cathy J Taylor
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK
    Mol Microbiol 69:110-8. 2008
    ..The data indicate that PfPDEdelta plays a crucial role in regulating cGMP levels during sexual development...
  90. pmc Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses
    Anna C van Brummelen
    Department of Biochemistry, University of Pretoria, Pretoria, Gauteng 0002, South Africa
    J Biol Chem 284:4635-46. 2009
    ..In contrast with previous reports, the results provide evidence that P. falciparum responds to alleviate the detrimental effects of polyamine depletion via regulation of its transcriptome and subsequently the proteome and metabolome...
  91. pmc Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane
    Reginald A Kavishe
    Department of Pharmacology and Toxicology 149, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Malar J 8:205. 2009
    ..In order to understand the molecular mechanisms underlying drug resistance, characterization of these transporters is essential. The aim of this study was to characterize and localize putative ABC transporters...
  92. pmc Differential, positional-dependent transcriptional response of antigenic variation (var) genes to biological stress in Plasmodium falciparum
    Elli Rosenberg
    The Shraga Segal Department of Microbiology and Immunology, Ben Gurion University of Negev, Beer Sheva, Israel
    PLoS ONE 4:e6991. 2009
    ..As disease severity is partly associated with expression of particular var gene subtypes, manipulation of the IE environment may serve as a mechanism to direct transcription towards less virulent genes...
  93. doi MAHRP2, an exported protein of Plasmodium falciparum, is an essential component of Maurer's cleft tethers
    Esther Pachlatko
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Mol Microbiol 77:1136-52. 2010
    ..Solubilization studies showed that MAHRP2 is membrane associated but not membrane spanning. Several attempts to delete the mahrp2 gene failed, indicating that the protein is essential for parasite survival...
  94. pmc Validation of isoleucine utilization targets in Plasmodium falciparum
    Eva S Istvan
    Department of Medicine and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 108:1627-32. 2011
    ..This approach is generally useful for elucidation of new targets in P. falciparum. Our study shows that isoleucine utilization is an essential pathway that can be targeted for antimalarial drug development...
  95. doi The cysteine-rich regions of Plasmodium falciparum RON2 bind with host erythrocyte and AMA1 during merozoite invasion
    Mohammad E Hossain
    International Centre for Genetic Engineering and Biotechnology, New Delhi, 110 067, India
    Parasitol Res 110:1711-21. 2012
    ..These results suggest that PfRON2 plays a role in merozoite invasion and thus it can be an important vaccine candidate antigen...
  96. pmc Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
    Stephan Meister
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 334:1372-7. 2011
    ..The open-source chemical tools resulting from our effort provide starting points for future drug discovery programs, as well as opportunities for researchers to investigate the biology of exo-erythrocytic forms...
  97. doi Plasmodium falciparum centromeres display a unique epigenetic makeup and cluster prior to and during schizogony
    Wieteke A M Hoeijmakers
    Department of Molecular Biology, Radboud University, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Cell Microbiol 14:1391-401. 2012
    ..These findings suggest that DNA-associated and epigenetic elements play an important role in centromere establishment in this important human pathogen...
  98. pmc Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites
    Eric Salazar
    Tri Institutional MD PhD Program, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, New York, United States of America
    PLoS ONE 7:e39769. 2012
    ..One particular inhibitor is selective for PfACβ relative to its human ortholog, soluble adenylyl cyclase (sAC); thus, PfACβ represents a potential target for development of safe and effective antimalarial therapeutics...
  99. pmc Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy
    Aline Fréville
    Center for Infection and Immunity of Lille, INSERM U1019 CNRS UMR 8204, University of Lille Nord de France, Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019 Lille, Cedex, France
    BMC Biol 11:80. 2013
    ..Among these, inhibitor-2 (I2) is one of the most evolutionarily ancient PP1 regulators. In vivo studies in various organisms revealed a defect in chromosome segregation and cell cycle progression when the function of I2 is blocked...
  100. ncbi A new blood stage antigen of Plasmodium falciparum transported to the erythrocyte surface
    B Knapp
    Department of Molecular Biology, Behringwerke AG, Marburg, F R G
    Mol Biochem Parasitol 37:47-56. 1989
    ..The 41-2 protein could be localized in the schizont membrane, associated with membranous structures in the erythrocytic cytoplasm and with the erythrocyte membrane...
  101. ncbi Merozoite surface protein 8 of Plasmodium falciparum contains two epidermal growth factor-like domains
    C G Black
    Department of Microbiology, PO Box 53, Monash University, 3800, Victoria, Australia
    Mol Biochem Parasitol 114:217-26. 2001
    ..suggesting that the two proteins are homologues. Taken together, these findings suggest that MSP8/pypAg-2 may play an important role in the process of red cell invasion and is a potential malaria vaccine candidate...

Research Grants9

  1. Translational Control in Plasmodium Sexual Development
    Liwang Cui; Fiscal Year: 2005
    ....
  2. Plasmodium vivax:Proteomic Analysis of Asexual and Sporozoite Stages
    Liwang Cui; Fiscal Year: 2007
    ..Its recent resurgence in prevalence and emergence of drug- resistant parasite strains have raised a great concern for the future control of malaria. [unreadable] [unreadable] [unreadable]..
  3. Development of a cell-based method for high-throughput drug screening in malaria
    Liwang Cui; Fiscal Year: 2008
    ..To facilitate antimalarial drug discovery, we propose to develop a highly sensitive, cell-based, one-step luminescent drug screen assay for high throughput screening of large chemical libraries. [unreadable] [unreadable] [unreadable]..
  4. Proteomic analysis of the T. gondii vacuolar membrane
    Anthony Sinai; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  5. Blockade of host apoptosis by Toxoplasma gondii
    Anthony P Sinai; Fiscal Year: 2010
    ..Dissection of these pathways is particularly important given the targets of NFKB many of the cytokines implicated both in the pathogenesis of acute toxoplasmosis and the development of immunity to the parasite. ..
  6. A Tetravalent Dengue Recombinanat Protein Vaccine
    B Sim; Fiscal Year: 2005
    ..abstract_text> ..
  7. A SARS-CoV Spike Protein Vaccine
    B Sim; Fiscal Year: 2005
    ..abstract_text> ..
  8. Plasmodium vivax recombinant CS protein vaccine
    B Sim; Fiscal Year: 2006
    ..abstract_text> ..
  9. Inhibition of Alzheimer's Beta-Amyloid Fibril Formation
    Duy Hua; Fiscal Year: 2009
    ..However, soluble oligomeric Abeta showed high neuronal toxicity. Inhibition of the formation of these toxic soluble Abeta oligomers would provide therapeutics for AD. ..

Patents15

  1. A PROCESS FOR ENGINEERING NUCLEOTIDE SPECIFICITY
    Patent Number: WO2016103276-A1; Date:2016-06-30
  2. Vaccine composition against malaria
    Patent Number: JP2014520563-A; Date:2014-08-25
  3. Recombinant plasmodium falciparum merozoite protein-1/42 vaccine
    Patent Number: WO02058727-A2; Date:2002-08-01
  4. Isolation and purification of p. Falciparum merozoite protein-1 42? vaccine
    Patent Number: WO03004525-A2; Date:2003-01-16
  5. Baculoviral vectors with a dual vertebrate and baculovirus promoter controlling an immunogenic fusion gene
    Patent Number: WO2009020236-A1; Date:2009-02-12
  6. Process for the production of fine chemicals
    Patent Number: EP2080769-A2; Date:2009-07-22
  7. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  8. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  9. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  10. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  11. ATTENUATED PLASMODIUM WITH DEACTIVATED HMGB2 GENE, AS VACCINE
    Patent Number: WO2013011247-A1; Date:2013-01-24
  12. CONDITIONAL KNOCKOUT MUTANTS OF SORTILIN-LIKE RECEPTOR IN APICOMPLEXAN PARASITES AND USES THEREOF
    Patent Number: WO2012175410-A1; Date:2012-12-27
  13. No title supplied
    Patent Number: WO2006056468-A1; Date:2006-06-01
  14. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  15. NOVEL VIRAL VECTOR
    Patent Number: JP2010535466-A; Date:2010-11-25