Caulobacter crescentus CB15

Summary

Alias: Caulobacter crescentus str. CB15, Caulobacter vibrioides CB15, Caulobacter crescentus CB 15, Caulobacter crescentus strain CB15, Caulobacter vibrioides ATCC 19089

Top Publications

  1. ncbi Polar localization of a bacterial chemoreceptor
    M R Alley
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305 5427
    Genes Dev 6:825-36. 1992
  2. pmc A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus
    S P Wang
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    Proc Natl Acad Sci U S A 90:630-4. 1993
  3. ncbi Cell cycle control by an essential bacterial two-component signal transduction protein
    K C Quon
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305 5427, USA
    Cell 84:83-93. 1996
  4. ncbi Cell cycle-dependent polar localization of chromosome partitioning proteins in Caulobacter crescentus
    D A Mohl
    Department of Chemistry and Biochemistry and Molecular Biology Institute, University of California, Los Angeles 90095 1569, USA
    Cell 88:675-84. 1997
  5. ncbi Ordered expression of ftsQA and ftsZ during the Caulobacter crescentus cell cycle
    M J Sackett
    Department of Chemistry, Indiana University, Bloomington 47405, USA
    Mol Microbiol 28:421-34. 1998
  6. pmc An essential protease involved in bacterial cell-cycle control
    U Jenal
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    EMBO J 17:5658-69. 1998
  7. ncbi The bacterial cytoskeleton: an intermediate filament-like function in cell shape
    Nora Ausmees
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 115:705-13. 2003
  8. pmc A temperature-sensitive mutation in the dnaE gene of Caulobacter crescentus that prevents initiation of DNA replication but not ongoing elongation of DNA
    Teresa Lo
    Department of Biology, Loyola College, Baltimore, Maryland 21210, USA
    J Bacteriol 186:1205-12. 2004
  9. ncbi Oscillating global regulators control the genetic circuit driving a bacterial cell cycle
    Julia Holtzendorff
    Department of Developmental Biology, School of Medicine, Beckman Center, Stanford University, Stanford, CA 94305, USA
    Science 304:983-7. 2004
  10. ncbi Cell cycle-dependent abundance, stability and localization of FtsA and FtsQ in Caulobacter crescentus
    Miriam E Martin
    Department of Biology, Indiana University, 1001 E 3rd St, Bloomington, IN 47405, USA
    Mol Microbiol 54:60-74. 2004

Research Grants

  1. Bacterial MreB/actin Cytoskeleton and Cell Polarity
    Zemer Gitai; Fiscal Year: 2005
  2. Type IV Secretion Systems in Legionella pneumophila
    Howard M Steinman; Fiscal Year: 2010
  3. SCienceLab
    Bert Ely; Fiscal Year: 2010

Patents

  1. DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
  2. Method for producing target substance
  3. Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
  4. Method of producing Protocatechuic acid
  5. Process for the production of a fine chemical
  6. Proteins associated with abiotic stress response and homologs
  7. Method of producing gallic acid
  8. DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
  9. Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
  10. Yield increase in plants overexpressing the accdp genes

Scientific Experts

  • Masayoshi Sakaguchi
  • U Jenal
  • Tomohiro Hiraishi
  • Zemer Gitai
  • Marilis do Valle Marques
  • Patrick H Viollier
  • BERT E ELY
  • J Maddock
  • G Leclerc
  • HOWARD STEINMAN
  • C Stephens
  • A M Simm
  • C D Mohr
  • Erin D Goley
  • Lucy Shapiro
  • Christine Jacobs-Wagner
  • Yves V Brun
  • Bum Han Ryu
  • Sunish Kumar Radhakrishnan
  • Grant R Bowman
  • Martin Thanbichler
  • John Smit
  • Ralf Paul
  • Hubert Lam
  • L Shapiro
  • Michael T Laub
  • Antonio A Iniesta
  • Kirstine L Bendtsen
  • Kathleen R Ryan
  • Emanuele G Biondi
  • Harley H McAdams
  • T Doohun Kim
  • Tri Duc Ngo
  • Kyeong Kyu Kim
  • Brandon Williams
  • Peter Chien
  • Michelle F Susin
  • Andrea Harms
  • Géraldine Laloux
  • Kristina Jonas
  • Carmen Fernandez-Fernandez
  • Monica A Schwartz
  • Natalie A Dye
  • N Ohta
  • Gail G Hardy
  • Noriko Ohta
  • Austin Newton
  • Jay H Russell
  • James A Taylor
  • Kenneth H Downing
  • Andrea Moll
  • Luis R Comolli
  • S M Shaheen
  • Paul D Cook
  • A Newton
  • D A Mullin
  • Sean Pritchard
  • Teresa Costa
  • Gitte Ebersbach
  • Rebecca C Allen
  • Raquel Paes da Rocha
  • Valerie Guillet
  • Stephanie Cabantous
  • Grant J Jensen
  • Y V Brun
  • Michelle Aaron
  • Gregory T Marczynski
  • Zhuo Li
  • Paul Wassmann
  • Matthew J Ford
  • Deanne L Pierce
  • R S Janakiraman
  • Patrick T McGrath
  • Ivana De Domenico
  • Edgar Huitema
  • Michael J Trimble
  • John F Nomellini
  • Suely L Gomes
  • Jennifer K Wagner
  • Boris Gorbatyuk
  • Stephen A Sciochetti
  • Rita C G Simão
  • M Osteras
  • Mihai Iuga
  • Julia Holtzendorff
  • Jean Yves Matroule
  • Miriam E Martin
  • Teresa Lo
  • Boo Young Kim
  • Christian N S Pedersen

Detail Information

Publications107 found, 100 shown here

  1. ncbi Polar localization of a bacterial chemoreceptor
    M R Alley
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305 5427
    Genes Dev 6:825-36. 1992
    ..These results suggest that subcellular localization of a prokaryotic protein involves interaction of specific regions of the protein with unique cell sites that contain either localized binding proteins or a specific secretory apparatus...
  2. pmc A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus
    S P Wang
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    Proc Natl Acad Sci U S A 90:630-4. 1993
    ..The use of a phosphorelay system cued to internal changes in the cell would provide a mechanism for coordinating major changes in gene expression with the completion of specific cell cycle events...
  3. ncbi Cell cycle control by an essential bacterial two-component signal transduction protein
    K C Quon
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, California 94305 5427, USA
    Cell 84:83-93. 1996
    ....
  4. ncbi Cell cycle-dependent polar localization of chromosome partitioning proteins in Caulobacter crescentus
    D A Mohl
    Department of Chemistry and Biochemistry and Molecular Biology Institute, University of California, Los Angeles 90095 1569, USA
    Cell 88:675-84. 1997
    ..These results suggest that ParA and ParB are involved in partitioning newly replicated chromosomes to the poles of the predivisional cell and may function as components of a bacterial mitotic apparatus...
  5. ncbi Ordered expression of ftsQA and ftsZ during the Caulobacter crescentus cell cycle
    M J Sackett
    Department of Chemistry, Indiana University, Bloomington 47405, USA
    Mol Microbiol 28:421-34. 1998
    ..Thus, transcription of ftsA and ftsZ mimics their order of action in Caulobacter and proper transcription of ftsA has to be maintained for normal cell division and differentiation...
  6. pmc An essential protease involved in bacterial cell-cycle control
    U Jenal
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    EMBO J 17:5658-69. 1998
    ..In particular, CtrA negatively controls DNA replication and our findings suggest that specific degradation of the CtrA protein by the ClpXP protease contributes to G1-to-S transition in this organism...
  7. ncbi The bacterial cytoskeleton: an intermediate filament-like function in cell shape
    Nora Ausmees
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 115:705-13. 2003
    ..We propose that IF-like filaments of crescentin assemble into a helical structure, which by applying its geometry to the cell, generates a vibrioid or helical cell shape depending on the length of the cell...
  8. pmc A temperature-sensitive mutation in the dnaE gene of Caulobacter crescentus that prevents initiation of DNA replication but not ongoing elongation of DNA
    Teresa Lo
    Department of Biology, Loyola College, Baltimore, Maryland 21210, USA
    J Bacteriol 186:1205-12. 2004
    ....
  9. ncbi Oscillating global regulators control the genetic circuit driving a bacterial cell cycle
    Julia Holtzendorff
    Department of Developmental Biology, School of Medicine, Beckman Center, Stanford University, Stanford, CA 94305, USA
    Science 304:983-7. 2004
    ..CtrA functions as a silencer of the replication origin and GcrA as an activator of components of the replisome and the segregation machinery...
  10. ncbi Cell cycle-dependent abundance, stability and localization of FtsA and FtsQ in Caulobacter crescentus
    Miriam E Martin
    Department of Biology, Indiana University, 1001 E 3rd St, Bloomington, IN 47405, USA
    Mol Microbiol 54:60-74. 2004
    ....
  11. pmc Caulobacter crescentus requires RodA and MreB for stalk synthesis and prevention of ectopic pole formation
    Jennifer K Wagner
    Department of Biology, Indiana University, Bloomington, IN 47405 3700, USA
    J Bacteriol 187:544-53. 2005
    ..We conclude that MreB, RodA, and the target(s) of amdinocillin all contribute to the maintenance of cellular polarity in C. crescentus...
  12. ncbi Regulated degradation of chromosome replication proteins DnaA and CtrA in Caulobacter crescentus
    Boris Gorbatyuk
    Department of Microbiology and Immunology, McGill University, 3775 University Street, Room 506, Montreal, Quebec, H3A 2B4, Canada
    Mol Microbiol 55:1233-45. 2005
    ..This unexpected and finely tuned proteolysis system may be an important adaptation for a developmental bacterium that is often challenged by nutrient-poor environments...
  13. ncbi MreB actin-mediated segregation of a specific region of a bacterial chromosome
    Zemer Gitai
    Department of Developmental Biology, Beckman Center, School of Medicine, Stanford University, California 94305, USA
    Cell 120:329-41. 2005
    ..MreB selectively interacts, directly or indirectly, with origin-proximal regions of the chromosome, arguing that the origin-proximal region segregates via an MreB-dependent mechanism not used by the rest of the chromosome...
  14. ncbi A dynamically localized protease complex and a polar specificity factor control a cell cycle master regulator
    Patrick T McGrath
    Department of Physics, Stanford University, Stanford, CA 94305, USA
    Cell 124:535-47. 2006
    ..Thus, a dynamically localized ClpXP proteolysis complex in concert with a cytoplasmic factor provides temporal and spatial specificity to protein degradation during a bacterial cell cycle...
  15. ncbi MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter
    Martin Thanbichler
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, 279 Campus Drive, Stanford, CA 94305, USA
    Cell 126:147-62. 2006
    ..The cellular localization of MipZ thus serves the dual function of positioning the FtsZ ring and delaying formation of the cell division apparatus until chromosome segregation has initiated...
  16. ncbi Regulation of the bacterial cell cycle by an integrated genetic circuit
    Emanuele G Biondi
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 444:899-904. 2006
    ..Our results define a single integrated circuit whose components and connectivity can account for the cell cycle oscillations of CtrA in Caulobacter...
  17. pmc The structure of FtsZ filaments in vivo suggests a force-generating role in cell division
    Zhuo Li
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    EMBO J 26:4694-708. 2007
    ....
  18. pmc A polymeric protein anchors the chromosomal origin/ParB complex at a bacterial cell pole
    Grant R Bowman
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, Stanford, CA 94305, USA
    Cell 134:945-55. 2008
    ....
  19. pmc A self-associating protein critical for chromosome attachment, division, and polar organization in caulobacter
    Gitte Ebersbach
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 134:956-68. 2008
    ..Instead, evidence suggests that localization of PopZ largely relies on PopZ multimerization in chromosome-free regions, consistent with a self-organizing mechanism...
  20. pmc Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function
    Grant R Bowman
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Microbiol 76:173-89. 2010
    ..We propose that pole-specific control of PopZ function co-ordinates polar development and cell cycle progression by enabling independent assembly and tethering activities at the two cell poles...
  21. pmc Cell pole-specific activation of a critical bacterial cell cycle kinase
    Antonio A Iniesta
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:7012-7. 2010
    ..Because DivL and CckA accumulate at the same cell pole after the initiation of DNA replication and were found to interact in vivo, we propose that DivL recruits CckA to the pole, thereby promoting its autophosphorylation and activity...
  22. pmc Identification of a Caulobacter crescentus operon encoding hrcA, involved in negatively regulating heat-inducible transcription, and the chaperone gene grpE
    R C Roberts
    Department of Developmental Biology, Stanford University School of Medicine, California 94305 5427, USA
    J Bacteriol 178:1829-41. 1996
    ....
  23. pmc Mutations in DivL and CckA rescue a divJ null mutant of Caulobacter crescentus by reducing the activity of CtrA
    Deanne L Pierce
    Indiana University, Department of Biology, 1001 E 3rd Street, Bloomington, IN 47405, USA
    J Bacteriol 188:2473-82. 2006
    ..In vivo phosphorylation assays confirmed that divJ mutants have elevated levels of CtrA phosphorylation and that this level is reduced in the suppressors with mutations in divL...
  24. ncbi The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus
    Michelle Aaron
    Department of Molecular, Cellular, and Developmental Biology, and Microbiology Program, Yale University, New Haven, CT 06520, USA
    Mol Microbiol 64:938-52. 2007
    ..Evidence suggests that bacteria use both a FtsZ-independent and a FtsZ-dependent mode of peptidoglycan synthesis to elongate, the importance of each mode depending on the timing of FtsZ assembly during elongation...
  25. doi Structure of a novel lipid A obtained from the lipopolysaccharide of Caulobacter crescentus
    John Smit
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    Innate Immun 14:25-37. 2008
    b>Caulobacter crescentus CB15 is a dimorphic bacterium that is best known as a prokaryotic model for cell development...
  26. ncbi Organization and ordered expression of Caulobacter genes encoding flagellar basal body rod and ring proteins
    A Dingwall
    Department of Developmental Biology, Stanford University School of Medicine, CA 94305 5427
    J Mol Biol 228:1147-62. 1992
    ..The sequential activation of these three subgroups of structural genes reflects the order of assembly of their gene products into the flagellum...
  27. ncbi Cell-cycle control of a cloned chromosomal origin of replication from Caulobacter crescentus
    G T Marczynski
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, CA 94305
    J Mol Biol 226:959-77. 1992
    ..The latter two motifs are implicated in essential C. crescentus replication functions, because they are contained within specific deletions that abolish replication...
  28. pmc The cell cycle-regulated flagellar gene flbF of Caulobacter crescentus is homologous to a virulence locus (lcrD) of Yersinia pestis
    G Ramakrishnan
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014
    J Bacteriol 173:7283-92. 1991
    ....
  29. ncbi Temporal regulation and overlap organization of two Caulobacter flagellar genes
    J B Kaplan
    Department of Microbiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032
    J Mol Biol 205:71-83. 1989
    ..The entire promoter region and an upstream consensus sequence that might be a regulatory element for the flaY gene lies within the carboxyl-terminal coding sequence of the flaE gene...
  30. pmc Transcriptional analysis of the major surface array gene of Caulobacter crescentus
    J A Fisher
    Naval Bioscience Laboratory, School of Public Health, University of California Berkeley 94720
    J Bacteriol 170:4706-13. 1988
    The major component of the paracrystalline surface array of Caulobacter crescentus CB15 and one of the most abundant cellular proteins is a protein designated 130K...
  31. ncbi Copper-zinc superoxide dismutase from Caulobacter crescentus CB15. A novel bacteriocuprein form of the enzyme
    H M Steinman
    J Biol Chem 257:10283-93. 1982
    ..has been discovered, purified, and characterized from the free living, non-symbiotic bacterium, Caulobacter crescentus CB15. In its native molecular weight, homodimeric subunit structure, specific activity, and metal content, ..
  32. pmc An essential single domain response regulator required for normal cell division and differentiation in Caulobacter crescentus
    G B Hecht
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, NJ 08544, USA
    EMBO J 14:3915-24. 1995
    ..We suggest that phosphotransfer mediated by these two-component signal transduction systems may represent a general mechanism regulating cell differentiation and cell division in response to successive cell cycle checkpoints...
  33. pmc Identification, characterization, and chromosomal organization of cell division cycle genes in Caulobacter crescentus
    N Ohta
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    J Bacteriol 179:2169-80. 1997
    ..On the basis of these results, we suggest that the C. crescentus divA-divB-divE(ftsA)-ftsZ gene cluster corresponds to the 2-min fts gene cluster of Escherichia coli...
  34. ncbi Genetic organization and transposition properties of IS511
    D A Mullin
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Mol Gen Genet 254:456-63. 1997
    IS511 is an endogenous insertion sequence (IS) of the bacterium Caulobacter crescentus strain CB15 and it is the first Caulobacter IS to be characterized at the molecular level...
  35. pmc Cell cycle control of a holdfast attachment gene in Caulobacter crescentus
    R S Janakiraman
    Department of Biology, Indiana University, Bloomington, Indiana 47405 6801, USA
    J Bacteriol 181:1118-25. 1999
    ..This increase in expression is largely due to the preferential transcription of hfaA in the swarmer pole of the predivisional cell...
  36. ncbi Biochemical and molecular characterization of poly(aspartic acid) hydrolase-2 from sphingomonas sp. KT-1
    Tomohiro Hiraishi
    Polymer Chemistry Laboratory, RIKEN Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Biomacromolecules 4:1285-92. 2003
    ..KT-1 was cloned, and genetic analysis showed that the deduced amino acid sequence of PAA hydrolase-2 is similar to a putative peptidase, which belongs to the M20/M25/M40 family of proteins, from Caulobacter crescentus CB15.
  37. ncbi The role of polar localization in the function of an essential Caulobacter crescentus tyrosine kinase
    Stephen A Sciochetti
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Microbiol 56:1467-80. 2005
    ..Thus, subcellular localization of DivL is not essential to its function in cell division regulation. Regulation of cell division by DivL does, however, depend on its localization in the cell membrane...
  38. ncbi Bacterial birth scar proteins mark future flagellum assembly site
    Edgar Huitema
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell 124:1025-37. 2006
    ..Thus TipN and TipF establish a link between bacterial cytokinesis and polar asymmetry, demonstrating that division does indeed leave a positional mark in its wake to direct the biogenesis of a polar organelle...
  39. pmc S-layer anchoring and localization of an S-layer-associated protease in Caulobacter crescentus
    Matthew J Ford
    Department of Microbiology and Immunology, University of British Columbia, 2509 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    J Bacteriol 189:2226-37. 2007
    ..Moreover, Sap was secreted to the cell surface primarily by the S-layer type I secretion apparatus...
  40. ncbi Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition
    Paul Wassmann
    Core Program of Structural Biology and Biophysics, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Structure 15:915-27. 2007
    ..Here, a second mode is observed that crosslinks the DGC domains within a PleD dimer. Both modes cause noncompetitive product inhibition by domain immobilization...
  41. pmc Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate
    Ralf Paul
    Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Cell 133:452-61. 2008
    ..crescentus. Thus, single domain response regulators can facilitate crosstalk, feedback control, and long-range communication among members of the two-component network...
  42. pmc The β-sliding clamp directs the localization of HdaA to the replisome in Caulobacter crescentus
    Carmen Fernandez-Fernandez
    Department of Fundamental Microbiology, Faculty of Biology and Medicine, University of Lausanne, Quartier UNIL Sorge, Lausanne, CH 1015, Switzerland
    Microbiology 159:2237-48. 2013
    ..The AAA+ domain of HdaA may therefore be required during RIDA after the initial recruitment of HdaA to the replisome by DnaN. ..
  43. pmc Glucoamylase of Caulobacter crescentus CB15: cloning and expression in Escherichia coli and functional identification
    Masayoshi Sakaguchi
    Department of Applied Chemistry, Kogakuin University, 2, 665 1 Nakano cho, Hachioji, Tokyo 192 0015, Japan
    AMB Express 4:5. 2014
    The biochemical properties of the maltodextrin-hydrolyzing enzymes of cold-tolerant proteobacterium Caulobacter crescentus CB15 remain to be elucidated, although whose maltodextrin transport systems were well investigated...
  44. pmc ClpXP and ClpAP proteolytic activity on divisome substrates is differentially regulated following the Caulobacter asymmetric cell division
    Brandon Williams
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA
    Mol Microbiol 93:853-66. 2014
    ..Taken together, these results suggest that the activity of both ClpXP and ClpAP on divisome substrates is differentially regulated in daughter cells. ..
  45. pmc Biochemical and Structural Analysis of a Novel Esterase from Caulobacter crescentus related to Penicillin-Binding Protein (PBP)
    Bum Han Ryu
    Department of Chemistry, College of Natural Science, Sookmyung Women s University, Seoul 140 742, Korea
    Sci Rep 6:37978. 2016
    ..Here, a novel PBP homologue (CcEstA) from Caulobacter crescentus CB15 was characterized using native-PAGE, mass spectrometry, gel filtration, CD spectroscopy, fluorescence, ..
  46. pmc Toxin inhibition in C. crescentus VapBC1 is mediated by a flexible pseudo-palindromic protein motif and modulated by DNA binding
    Kirstine L Bendtsen
    Centre for Bacterial Stress Response and Persistence
    Nucleic Acids Res . 2016
    ..Here, we determine crystal structures of the complete 90 kDa heterooctameric VapBC1 complex from Caulobacter crescentus CB15 both in isolation and bound to its cognate DNA operator sequence at 1.6 and 2...
  47. pmc Tracking of chromosome and replisome dynamics in Myxococcus xanthus reveals a novel chromosome arrangement
    Andrea Harms
    Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
    PLoS Genet 9:e1003802. 2013
    ..We conclude that M. xanthus chromosome arrangement and dynamics combine features from previously described systems with new features leading to a novel spatiotemporal arrangement pattern. ..
  48. pmc Proteotoxic stress induces a cell-cycle arrest by stimulating Lon to degrade the replication initiator DnaA
    Kristina Jonas
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 154:623-36. 2013
    ..Our work reveals a mechanism for regulating DNA replication under adverse growth conditions. Additionally, our data indicate that unfolded proteins can actively and directly alter substrate recognition by cellular proteases. ..
  49. pmc Spatiotemporal control of PopZ localization through cell cycle-coupled multimerization
    Géraldine Laloux
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA
    J Cell Biol 201:827-41. 2013
    ..Such coupling of protein assembly with a cell cycle-associated molecular asymmetry may represent a principle of cellular organization for controlling protein localization in both time and space...
  50. pmc Mutations in the nucleotide binding pocket of MreB can alter cell curvature and polar morphology in Caulobacter
    Natalie A Dye
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA
    Mol Microbiol 81:368-94. 2011
    ..These mutant strains provide novel insight into how MreB's protein structure, subcellular localization, and activity contribute to its function in bacterial cell shape...
  51. pmc An SMC ATPase mutant disrupts chromosome segregation in Caulobacter
    Monica A Schwartz
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Microbiol 82:1359-74. 2011
    ..In wild-type cells, ATP hydrolysis opens the SMC dimer, freeing one chromosome to segregate to the opposite pole. The loss of ATP hydrolysis causes the SMC-E1076Q dimer to remain bound to both chromosomes, inhibiting segregation...
  52. pmc Identification, crystallization and preliminary X-ray diffraction analysis of esterase A from Caulobacter crescentus CB15, a family VIII lipolytic enzyme
    Bum Han Ryu
    Department of Molecular Science and Technology, Graduate School of Interdisciplinary Programs, Ajou University, Suwon 443 749, Republic of Korea
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:560-4. 2012
    ..Here, the X-ray crystallographic study of a family VIII esterase from Caulobacter crescentus CB15 (CcEstA) is described...
  53. pmc Molecular genetics of the flgI region and its role in flagellum biosynthesis in Caulobacter crescentus
    F M Khambaty
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    J Bacteriol 174:4101-9. 1992
    ..This is the first example of an operon containing both flagellar and chemotaxis genes in C. crescentus...
  54. ncbi Nucleotide sequence of the Caulobacter crescentus flaF and flbT genes and an analysis of codon usage in organisms with G + C-rich genomes
    P V Schoenlein
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    Gene 93:17-25. 1990
    ..Furthermore, comparison to the codon usage of other organisms with G + C-rich genomes indicated a strong preference for the same codons preferred by C. crescentus...
  55. pmc Analysis of a Caulobacter crescentus gene cluster involved in attachment of the holdfast to the cell
    H D Kurtz
    Department of Microbiology, University of British Columbia, Vancouver, Canada
    J Bacteriol 174:687-94. 1992
    ..This information suggests that the protein encoded by the hfaA locus may have a direct role in the attachment of the holdfast to the cell, whereas hfaB may be involved in the positive regulation of hfaC...
  56. pmc Identification, distribution, and sequence analysis of new insertion elements in Caulobacter crescentus
    N Ohta
    Department of Molecular Biology, Princeton University, New Jersey 08544
    J Bacteriol 172:236-42. 1990
    ..IS298 contains an imperfect terminal inverted repeat 16 bp long, and IS511 contains a 32-bp inverted repeat at the termini. IS298 and IS511 are the first insertion elements described in C. crescentus...
  57. pmc FlbD of Caulobacter crescentus is a homologue of the NtrC (NRI) protein and activates sigma 54-dependent flagellar gene promoters
    G Ramakrishnan
    Department of Biology, Lewis Thomas Laboratory, Princeton University, NJ 08544
    Proc Natl Acad Sci U S A 87:2369-73. 1990
    ..FlbD is also unusual in that its amino-terminal domain contains only one of the three residues conserved in previously described members of this family of response regulators...
  58. pmc Expression of the Caulobacter heat shock gene dnaK is developmentally controlled during growth at normal temperatures
    S L Gomes
    Departamento de Bioquimica, Universidade de Sao Paulo, Brazil
    J Bacteriol 172:3051-9. 1990
    ..K. L. Milarski and R. I. Morimoto, Proc. Natl. Acad. Sci. USA 83:9517-9521, 1986) and in a simple bacterium, the transcription of a hsp70 gene is temporally controlled as a function of the cell cycle under normal growth conditions...
  59. pmc Promoter mapping and cell cycle regulation of flagellin gene transcription in Caulobacter crescentus
    S A Minnich
    Proc Natl Acad Sci U S A 84:1142-6. 1987
    ..This result supports a model in which the timing of fla gene transcription in the C. crescentus cell cycle is determined in part by a cascade of trans-acting regulatory gene products...
  60. pmc Cloning of the major protein of the Caulobacter crescentus periodic surface layer: detection and characterization of the cloned peptide by protein expression assays
    J Smit
    J Bacteriol 160:1137-45. 1984
    A precisely ordered crystalline array is found on the surface of the bacterium Caulobacter crescentus CB15. Using an immunological assay, we identified recombinant bacteriophage clones expressing the predominant protein of this structure ..
  61. pmc Principal sigma subunit of the Caulobacter crescentus RNA polymerase
    J Malakooti
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    J Bacteriol 177:6854-60. 1995
    ..coli RNA polymerase, allowing the expression of C. crescentus promoters in E. coli. Thus, the C. crescentus sigma 73 appears to have a broader specificity than does the sigma 70 of the enteric bacteria...
  62. pmc Synthesis of the Caulobacter ferredoxin protein, FdxA, is cell cycle controlled
    S P Wang
    Department of Biological Sciences, University of South Carolina, Columbia 29208, USA
    J Bacteriol 177:2901-7. 1995
    ..crescentus. Further experiments demonstrated that the fdxA gene is temporally expressed in C. crescentus and that FdI is required for completion of the cell cycle at 37 degrees C...
  63. pmc Cell cycle arrest of a Caulobacter crescentus secA mutant
    P J Kang
    Department of Developmental Biology, Stanford University School of Medicine, California 94305 5427
    J Bacteriol 176:4958-65. 1994
    ..However, both cell division and stalk formation, which is analogous to a polar division event, require SecA function...
  64. pmc Identification and characterization of the ilvR gene encoding a LysR-type regulator of Caulobacter crescentus
    J Malakooti
    Department of Biological Sciences, University of South Carolina, Columbia 29208
    J Bacteriol 176:1275-81. 1994
    ..Amino acid sequence comparison revealed that the IlvR protein is a member of the LysR family of transcriptional regulators...
  65. pmc Expression of Caulobacter dnaA as a function of the cell cycle
    G Zweiger
    Department of Genetics, Stanford University School of Medicine, California 94305
    J Bacteriol 176:401-8. 1994
    ..Immunoprecipitation of a DnaA'-beta-lactamase fusion protein showed that although expression occurs throughout the cell cycle, there is a doubling in the rate of expression just prior to the initiation of replication...
  66. pmc Regulation of a heat shock sigma32 homolog in Caulobacter crescentus
    A Reisenauer
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5427, USA
    J Bacteriol 178:1919-27. 1996
    ..The isolation of rpoH provides an important tool for future studies of the role of sigma32 in the normal physiology of C. crescentus...
  67. pmc Cell cycle regulation and cell type-specific localization of the FtsZ division initiation protein in Caulobacter
    E Quardokus
    Department of Biology, Indiana University, Bloomington 47405 6801, USA
    Proc Natl Acad Sci U S A 93:6314-9. 1996
    ..Constitutive expression of FtsZ leads to defects in stalk biosynthesis suggesting a role for FtsZ in this developmental process in addition to its role in cell division...
  68. ncbi Expression of the groESL operon is cell-cycle controlled in Caulobacter crescentus
    M Avedissian
    Departamento de Bioquimica, Universidade de Sao Paulo, Brasil
    Mol Microbiol 19:79-89. 1996
    ..crescentus groESL expression...
  69. pmc Transcription of genes encoding DNA replication proteins is coincident with cell cycle control of DNA replication in Caulobacter crescentus
    R C Roberts
    Department of Developmental Biology, Stanford University School of Medicine, California 94305 5427, USA
    J Bacteriol 179:2319-30. 1997
    ....
  70. pmc An alkB gene homolog is differentially transcribed during the Caulobacter crescentus cell cycle
    D Colombi
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    J Bacteriol 179:3139-45. 1997
    ..crescentus. Nevertheless, transcription of the alkB gene is cell cycle controlled, with a pattern of expression similar to that of several Caulobacter genes involved in DNA replication...
  71. pmc Transcriptional and mutational analyses of the rpoN operon in Caulobacter crescentus
    R S Janakiraman
    Department of Biology, Indiana University, Bloomington 47405, USA
    J Bacteriol 179:5138-47. 1997
    ..The mutations have no effect on the transcription of previously known sigma54-dependent flagellar promoters except for a slight effect of an ORF159 mutation on transcription of fljK...
  72. pmc A gene coding for a putative sigma 54 activator is developmentally regulated in Caulobacter crescentus
    M V Marques
    Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
    J Bacteriol 179:5502-10. 1997
    ..These results suggest that the TacA protein could mediate the effect of sigma54 on a different pathway in C. crescentus...
  73. pmc Identification and transcriptional control of the genes encoding the Caulobacter crescentus ClpXP protease
    M Osteras
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Bacteriol 181:3039-50. 1999
    ..crescentus. Determination of the numbers of ClpP and ClpX molecules per cell suggested that ClpX is the limiting component compared with ClpP...
  74. pmc A novel bacterial tyrosine kinase essential for cell division and differentiation
    J Wu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 96:13068-73. 1999
    ..DivL is the only reported HPK homologue whose function has been shown to require autophosphorylation on a tyrosine, and, thus, it represents a new class of kinases within this superfamily of protein kinases...
  75. pmc Identification and cell cycle control of a novel pilus system in Caulobacter crescentus
    J M Skerker
    Department of Developmental Biology, Beckman Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    EMBO J 19:3223-34. 2000
    ....
  76. pmc A family of six flagellin genes contributes to the Caulobacter crescentus flagellar filament
    B Ely
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    J Bacteriol 182:5001-4. 2000
    ..Since these flagellins are the first to be assembled in the flagellar filament, one or both might have specialized to facilitate the initiation of filament assembly...
  77. ncbi FlbT, the post-transcriptional regulator of flagellin synthesis in Caulobacter crescentus, interacts with the 5' untranslated region of flagellin mRNA
    P E Anderson
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles, CA 90095 1569, USA
    Mol Microbiol 38:41-52. 2000
    ..Interestingly, the mutant transcript that failed to associate with FlbT in vitro was still repressed in mutants defective in flagellum assembly, suggesting that other factors in addition to FlbT couple assembly to translation...
  78. ncbi Precise amounts of a novel member of a phosphotransferase superfamily are essential for growth and normal morphology in Caulobacter crescentus
    T Fuchs
    Division of Molecular Microbiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Mol Microbiol 39:679-92. 2001
    ....
  79. ncbi Organization, expression, and function of Caulobacter crescentus genes needed for assembly and function of the flagellar hook
    D A Mullin
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Mol Genet Genomics 265:445-54. 2001
    ..We present evidence showing that, in addition to its role in termination of hook synthesis, FliK is also required for initiation of hook assembly...
  80. ncbi The Caulobacter crescentus outer membrane protein Omp58 (RsaF) is not required for paracrystalline S-layer secretion
    M Reichelt
    Chirurgische Forschung, Chirurgische Universitatsklinik, Hugstetter Strasse 55, D 79106 i Br, Freiburg, Germany
    FEMS Microbiol Lett 201:277-83. 2001
    ..crescentus surface-layer export system...
  81. ncbi Polyhydroxybutyrate biosynthesis in Caulobacter crescentus: molecular characterization of the polyhydroxybutyrate synthase
    Q Qi
    Institut für Mikrobiologie der Westfälischen Wilhelms Universität Münster, Corrensstrasse 3, 48149 Munster, Germany
    Microbiology 147:3353-8. 2001
    ..eutropha, contributing to approximately 62% and 6% of cell dry weight, respectively. Functional expression of the coding region of phaC was confirmed by immunoblotting and in vitro PHB synthase activity...
  82. ncbi A novel metallo-beta-lactamase, Mbl1b, produced by the environmental bacterium Caulobacter crescentus
    A M Simm
    Department of Pathology and Microbiology, University of Bristol, University Walk, UK
    FEBS Lett 509:350-4. 2001
    ..The main differences between Mbl1 and L1 are in the N-terminal region...
  83. ncbi Characterization and crystallization of DivK, an essential response regulator for cell division and differentiation in Caulobacter crescentus
    Stephanie Cabantous
    Groupe de Cristallographie Biologique IPBS CNRS, 205 route de Narbonne, 31077 Toulouse, France
    Acta Crystallogr D Biol Crystallogr 58:1249-51. 2002
    ..These crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 37.2, b = 40.5, c = 67.1 A and diffract beyond 1.6 A on a synchrotron beamline...
  84. ncbi Crystallographic and biochemical studies of DivK reveal novel features of an essential response regulator in Caulobacter crescentus
    Valerie Guillet
    Groupe de Cristallographie Biologique, IPBS CNRS, 205 route de Narbonne, 31077 Toulouse, France
    J Biol Chem 277:42003-10. 2002
    ....
  85. ncbi Role of the GGDEF regulator PleD in polar development of Caulobacter crescentus
    Phillip Aldridge
    Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Mol Microbiol 47:1695-708. 2003
    ..Possible roles for PleD and its C-terminal output domain in modulating the polar cell surface of C. crescentus are discussed...
  86. ncbi A lytic transglycosylase homologue, PleA, is required for the assembly of pili and the flagellum at the Caulobacter crescentus cell pole
    Patrick H Viollier
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, B343, 279 Campus Drive, Stanford, CA 94305, USA
    Mol Microbiol 49:331-45. 2003
    ..In support of this, PleA was found to be present only during a short interval in the cell cycle that coincides with the assembly of the flagellum and the pilus secretion apparatus...
  87. ncbi Cytokinesis monitoring during development; rapid pole-to-pole shuttling of a signaling protein by localized kinase and phosphatase in Caulobacter
    Jean Yves Matroule
    Department of Molecular, Cellular, and Developmental Biology, Yale University, P O Box 208103, New Haven, CT 06520, USA
    Cell 118:579-90. 2004
    ..Thus, dynamic polar localization of a diffusible protein provides a control mechanism that monitors cytokinesis to regulate development...
  88. ncbi Comparison of S-layer secretion genes in freshwater caulobacters
    Mihai Iuga
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
    Can J Microbiol 50:751-66. 2004
    ..Finally, while all of the S-layer proteins of this subset of strains were secreted by type I mechanisms, there were significant differences in genome positions of the transporter genes that correlated with S-layer protein size...
  89. ncbi Cells lacking ClpB display a prolonged shutoff phase of the heat shock response in Caulobacter crescentus
    Rita C G Simão
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, C P 26077, Sao Paulo, SP, 05513 970, Brazil
    Mol Microbiol 57:592-603. 2005
    ..Our findings also indicated that the absence of ClpB made cells more sensitive to heat shock and ethanol but not to other stresses, and unable to acquire thermotolerance...
  90. ncbi Purification and characterization of recombinant Caulobacter crescentus Cu,Zn superoxide dismutase
    Ivana De Domenico
    Department of Microbiological, Genetic and Molecular Sciences, University of Messina, Salita Sperone, 31, 98166 Messina, Italy
    Biochim Biophys Acta 1764:105-9. 2006
    ....
  91. ncbi A landmark protein essential for establishing and perpetuating the polarity of a bacterial cell
    Hubert Lam
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 124:1011-23. 2006
    ..Localization defects of the actin-like protein MreB in the DeltatipN mutant suggest that TipN is upstream of MreB in regulating cell polarity...
  92. pmc Characterization of the SOS regulon of Caulobacter crescentus
    Raquel Paes da Rocha
    Department of Microbiology, Institute of Biomedical Sciences, Sao Paulo University, Sao Paulo, Brazil
    J Bacteriol 190:1209-18. 2008
    ....
  93. pmc The dynamic interplay between a cell fate determinant and a lysozyme homolog drives the asymmetric division cycle of Caulobacter crescentus
    Sunish Kumar Radhakrishnan
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Genes Dev 22:212-25. 2008
    ..The dynamic interplay between SpmX and DivK is at the heart of the molecular circuitry that sustains the Caulobacter developmental cycle...
  94. pmc Localization of PBP3 in Caulobacter crescentus is highly dynamic and largely relies on its functional transpeptidase domain
    Teresa Costa
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Mol Microbiol 70:634-51. 2008
    ..Collectively, our results suggest a role for PBP3 in pole morphogenesis and provide new insights into the process of peptidoglycan assembly during division...
  95. doi Comparative analysis of Caulobacter chromosome replication origins
    S M Shaheen
    McGill University, Department of Microbiology and Immunology, Montreal, QC H3A 2B4, Canada
    Microbiology 155:1215-25. 2009
    ..Despite this similarity, phylogenetic analysis unexpectedly shows that CtrA usage evolved separately among these Caulobacter oris. We discuss consensus oris and convergent ori evolution in differentiating bacteria...
  96. doi FtsN-like proteins are conserved components of the cell division machinery in proteobacteria
    Andrea Moll
    Independent Junior Research Group Prokaryotic Cell Biology, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse 1, 35043 Marburg, Germany
    Mol Microbiol 72:1037-53. 2009
    ..coli and C. crescentus, we identified FtsN-like cell division proteins in beta- and delta-proteobacteria, suggesting that FtsN is widespread among bacteria, albeit highly variable at the sequence level...
  97. pmc Two site-directed mutations are required for the conversion of a sugar dehydratase into an aminotransferase
    Paul D Cook
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biochemistry 48:5246-53. 2009
    ..coli (strain 5a, type O55:H7) to that of GDP-perosamine synthase from Caulobacter crescentus CB15 suggested that only two mutations would be required to convert ColD into an aminotransferase...
  98. doi Mutations that alter RcdA surface residues decouple protein localization and CtrA proteolysis in Caulobacter crescentus
    James A Taylor
    Department of Plant and Microbial Biology, 251 Koshland Hall, University of California, Berkeley, Berkeley, CA 94720 3102, USA
    J Mol Biol 394:46-60. 2009
    ..Our results argue that RcdA stimulates CtrA proteolysis neither by localizing CtrA at the cell pole nor by preventing competition from SsrA-tagged substrates...
  99. doi Coupling prokaryotic cell fate and division control with a bifunctional and oscillating oxidoreductase homolog
    Sunish Kumar Radhakrishnan
    Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Dev Cell 18:90-101. 2010
    ....
  100. pmc Structure of the Caulobacter crescentus trpFBA operon
    C M Ross
    Department of Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611
    J Bacteriol 170:757-68. 1988
    ..crescentus and other bacteria. Taken together, these results are relevant to the analysis of gene expression in C. crescentus and the study of trp gene structure and regulation...
  101. ncbi A set of positively regulated flagellar gene promoters in Caulobacter crescentus with sequence homology to the nif gene promoters of Klebsiella pneumoniae
    D Mullin
    Department of Molecular Biology, Princeton University, NJ 08544
    J Mol Biol 195:939-43. 1987
    ..We speculate that the conserved sequence elements mapping at -13, -24 and -100 are cis-acting regulatory elements required for the transcription and periodic regulation of these fla genes in the C. crescentus cell cycle...

Research Grants3

  1. Bacterial MreB/actin Cytoskeleton and Cell Polarity
    Zemer Gitai; Fiscal Year: 2005
    ..By examining such a simple cell biological system, I hope to gain insight into the most fundamental mechanisms of actin-based regulation and cell polarity. ..
  2. Type IV Secretion Systems in Legionella pneumophila
    Howard M Steinman; Fiscal Year: 2010
    ....
  3. SCienceLab
    Bert Ely; Fiscal Year: 2010
    ..To address this problem, SCienceLab provides an opportunity for students to spend a day experiencing research and interacting with students who are working in a biomedical research laboratory. ..

Patents25

  1. DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
    Patent Number: JP2014131515-A; Date:2014-07-17
  2. Method for producing target substance
    Patent Number: WO2015060391-A; Date:2015-04-30
  3. Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
    Patent Number: JP2009504146-A; Date:2009-02-05
  4. Method of producing Protocatechuic acid
    Patent Number: JP2010207094-A; Date:2010-09-24
  5. Process for the production of a fine chemical
    Patent Number: WO2008034648-A1; Date:2008-03-27
  6. Proteins associated with abiotic stress response and homologs
    Patent Number: WO2007110314-A; Date:2007-10-04
  7. Method of producing gallic acid
    Patent Number: JP2009065839-A; Date:2009-04-02
  8. DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
    Patent Number: JP2006517412-A; Date:2006-07-27
  9. Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
    Patent Number: WO2007017270-A1; Date:2007-02-15
  10. Yield increase in plants overexpressing the accdp genes
    Patent Number: WO2007011625-A2; Date:2007-01-25
  11. Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms
    Patent Number: EP1752532-A1; Date:2007-02-14
  12. Diagnosis and treatment of multiple sulfatase deficiency and other using a formylglycine generating enzyme (fge)
    Patent Number: WO2004072275-A2; Date:2004-08-26
  13. DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES
    Patent Number: JP2012090630-A; Date:2012-05-17
  14. Plants with increased tolerance and/or resistance to environmental stress and increased biomass production
    Patent Number: WO2008142034-A2; Date:2008-11-27
  15. Proteins associated with abiotic stress response and homologs
    Patent Number: EP2221382-A2; Date:2010-08-25
  16. Process for the control of production of fine chemicals
    Patent Number: EP2199304-A1; Date:2010-06-23
  17. Process for the production of fine chemicals
    Patent Number: EP2194140-A2; Date:2010-06-09
  18. Plants with increased yield (nue)
    Patent Number: WO2010046221-A1; Date:2010-04-29
  19. Method for producing a transgenic plant cell, a plant or a part thereof with increased resistance biotic stress
    Patent Number: WO2010037714-A1; Date:2010-04-08
  20. Plants with increased yield (lt)
    Patent Number: WO2010034672-A1; Date:2010-04-01
  21. Process for the production of lutein
    Patent Number: EP2096177-A2; Date:2009-09-02
  22. Process for the production of a fine chemical
    Patent Number: EP2090662-A2; Date:2009-08-19
  23. Plants with increased yield
    Patent Number: WO2009037329-A2; Date:2009-03-26
  24. Plants with increased yield
    Patent Number: WO2009037279-A1; Date:2009-03-26
  25. Microbial synthesis of d-1,2,4-butanetriol
    Patent Number: WO2008091288-A2; Date:2008-07-31