COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDY

Summary

Principal Investigator: R L Gross
Abstract: The intent of this application is to document the ability of the Department of Ophthalmology, Baylor College of Medicine, to participate as an effective and productive clinical center in the proposed multi- center clinical trial entitled "Collaborative Initial Glaucoma Treatment Study (CIGTS)". This study's purpose is to evaluate whether initial treatment of open angle glaucoma is more effective by means of a stepped medical regimen or by means of a surgical approach. Baylor College of Medicine's Clinical Center will participate in the CIGTS by identifying and recruiting eligible patients, administering the treatment regimen as assigned by the CIGTS's coordinating center and defined within the study's Manual of Operations, following and retaining study patients, recording and transferring study data to the Coordinating Center, and contributing to reports that will present the CIGTS results. This application describes the ability of Baylor College of Medicine's Clinical Center to enroll approximately 24 patients per year, based on pilot studies of patient eligibility conducted during a three-month period. Details are provided of our plans to identify, recruit, follow and retain these patients, our intent to obtain consistently high- quality data on the visual outcomes of treatment, and the personnel and facilities available within our center to carry out the provisions of the CIGTS's Manual of Operations.
Funding Period: 1993-07-01 - 2003-12-31
more information: NIH RePORT

Top Publications

  1. pmc Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS)
    Sarwar Zahid
    Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan
    Am J Ophthalmol 155:674-680, 680.e1. 2013
  2. pmc The effect of early posttrabeculectomy intraocular pressure spike in the collaborative initial glaucoma treatment study
    Philip P Chen
    Department of Ophthalmology, University of Washington, 359608, Seattle, WA 98104 2499, USA
    J Glaucoma 20:211-4. 2011
  3. ncbi Perioperative complications of trabeculectomy in the collaborative initial glaucoma treatment study (CIGTS)
    Henry D Jampel
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 140:16-22. 2005
  4. pmc Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors
    David C Musch
    Department of Ophthalmology and Visual Sciences, The University of Michigan, Ann Arbor, Michigan 48105, USA
    Ophthalmology 116:200-7. 2009

Scientific Experts

  • P P Chen
  • H D Jampel
  • David C Musch
  • Sarwar Zahid
  • Paul R Lichter
  • Leslie M Niziol
  • Nancy K Janz
  • Brenda W Gillespie

Detail Information

Publications4

  1. pmc Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS)
    Sarwar Zahid
    Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan
    Am J Ophthalmol 155:674-680, 680.e1. 2013
    To report the risk of endophthalmitis and other long-term complications in patients randomized to trabeculectomy in the Collaborative Initial Glaucoma Treatment Study.
  2. pmc The effect of early posttrabeculectomy intraocular pressure spike in the collaborative initial glaucoma treatment study
    Philip P Chen
    Department of Ophthalmology, University of Washington, 359608, Seattle, WA 98104 2499, USA
    J Glaucoma 20:211-4. 2011
    To examine effects of early postoperative intraocular pressure (IOP) spike in patients undergoing primary trabeculectomy in the Collaborative Initial Glaucoma Treatment Study.
  3. ncbi Perioperative complications of trabeculectomy in the collaborative initial glaucoma treatment study (CIGTS)
    Henry D Jampel
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 140:16-22. 2005
    To describe the incidence of, and risk factors for, surgical complications reported during and within the first post-operative month after trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS).
  4. pmc Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors
    David C Musch
    Department of Ophthalmology and Visual Sciences, The University of Michigan, Ann Arbor, Michigan 48105, USA
    Ophthalmology 116:200-7. 2009
    To evaluate factors associated with visual field (VF) progression, using all available follow-up through 9 years after treatment initiation, in the Collaborative Initial Glaucoma Treatment Study (CIGTS).