COLLABORATIVE INITIAL GLAUCOMA TREATMENT STUDY
Principal Investigator: R L Gross
Abstract: The intent of this application is to document the ability of the Department of Ophthalmology, Baylor College of Medicine, to participate as an effective and productive clinical center in the proposed multi- center clinical trial entitled "Collaborative Initial Glaucoma Treatment Study (CIGTS)". This study's purpose is to evaluate whether initial treatment of open angle glaucoma is more effective by means of a stepped medical regimen or by means of a surgical approach. Baylor College of Medicine's Clinical Center will participate in the CIGTS by identifying and recruiting eligible patients, administering the treatment regimen as assigned by the CIGTS's coordinating center and defined within the study's Manual of Operations, following and retaining study patients, recording and transferring study data to the Coordinating Center, and contributing to reports that will present the CIGTS results. This application describes the ability of Baylor College of Medicine's Clinical Center to enroll approximately 24 patients per year, based on pilot studies of patient eligibility conducted during a three-month period. Details are provided of our plans to identify, recruit, follow and retain these patients, our intent to obtain consistently high- quality data on the visual outcomes of treatment, and the personnel and facilities available within our center to carry out the provisions of the CIGTS's Manual of Operations.
Funding Period: 1993-07-01 - 2003-12-31
more information: NIH RePORT
- Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS)Sarwar Zahid
Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan
Am J Ophthalmol 155:674-680, 680.e1. 2013To report the risk of endophthalmitis and other long-term complications in patients randomized to trabeculectomy in the Collaborative Initial Glaucoma Treatment Study.
- The effect of early posttrabeculectomy intraocular pressure spike in the collaborative initial glaucoma treatment studyPhilip P Chen
Department of Ophthalmology, University of Washington, 359608, Seattle, WA 98104 2499, USA
J Glaucoma 20:211-4. 2011To examine effects of early postoperative intraocular pressure (IOP) spike in patients undergoing primary trabeculectomy in the Collaborative Initial Glaucoma Treatment Study.
- Perioperative complications of trabeculectomy in the collaborative initial glaucoma treatment study (CIGTS)Henry D Jampel
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Ophthalmol 140:16-22. 2005To describe the incidence of, and risk factors for, surgical complications reported during and within the first post-operative month after trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS).
- Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factorsDavid C Musch
Department of Ophthalmology and Visual Sciences, The University of Michigan, Ann Arbor, Michigan 48105, USA
Ophthalmology 116:200-7. 2009To evaluate factors associated with visual field (VF) progression, using all available follow-up through 9 years after treatment initiation, in the Collaborative Initial Glaucoma Treatment Study (CIGTS).