Integrating Sex & Drug Related HIV Risk & Transmission
Principal Investigator: R Heimer
Abstract: In response to the RFA "Diffusion of HIV Infection through Sexual Risk Behaviors of Drug Users", a team of established researchers from Yale University, the Hispanic Health Council, the Biomedical Center in St. Petersburg, Russia, and Imperial College, London have established a consortium. Together, they will participate as a single entity in the Sexual Acquisition and Transmission of HIV Cooperation Agreement Program (SATH-CAP). The multidisciplinary team will employ the methodologies of behavioral and molecular epidemiology, medical sociology and anthropology, and mathematical modeling to investigate the behaviors of injection drug users and their sex partners in two locations - Connecticut and St. Petersburg. These two sites have been chosen since they differ in terms of the stage of the HIV-1 epidemic among injectors. In Connecticut, the epidemic appears to be under control, with stable or declining prevalence; in St. Petersburg, the epidemic appears to be on the increase, with high incidence and rising prevalence. This application has four specific aims: 1) to establish a multidisciplinary team based on our competences and expertise to investigate the sexual and syringeborne transmission of HIV and other pathogens among populations of drug users and from drug users to the broader population; 2) to employ a multidisciplinary approach to investigate the dynamics of sexual and syringe-borne disease transmission in cohorts of injection drug users and their sexual partners in the two locations; 3) to trace sexual transmitted HIV-1 infections in St. Petersburg back to injectors to investigate the expansion of the epidemic from one concentrated in injectors to a more generalized one; and 4) to develop mathematical models and projections of disease spread in these populations that are informed by the quantitative, qualitative, and biological data.
Funding Period: 2003-09-30 - 2010-06-30
more information: NIH RePORT
- HIV transmission from drug injectors to partners who do not inject, and beyond: modelling the potential for a generalized heterosexual epidemic in St. Petersburg, RussiaHarriet L Mills
Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom Electronic address
Drug Alcohol Depend 133:242-7. 2013..Petersburg and their non-injecting heterosexual partners (PIDUs). There are fears that sexual transmission of HIV from IDUs to PIDUs may portend a self-sustaining, heterosexual epidemic in Russia...
- Correlates of unprotected sexual intercourse among women who inject drugs or who have sexual partners who inject drugs in St Petersburg, RussiaNadia Abdala
Yale School of Public Health, New Haven, CT, USA
J Fam Plann Reprod Health Care 39:179-85. 2013..To assess risk for unintended pregnancy, this study describes the correlates of unprotected sexual intercourse (UPSI) among women who inject illicit drugs or who have sexual partners who inject drugs in St Petersburg, Russia...
- Potential bridges of heterosexual HIV transmission from drug users to the general population in St. Petersburg, Russia: is it easy to be a young female?Olga Toussova
The Biomedical Center, St Petersburg, Russia
J Urban Health 86:121-30. 2009..5, CI = 1.3-9.6) were significant correlates for ever having had an IDU SP. Urgent efforts are necessary to expand HIV prevention to target the potential bridging population to prevent further transmission...
- Age at first alcoholic drink as predictor of current HIV sexual risk behaviors among a sample of injection drug users (IDUs) and non-IDUs who are sexual partners of IDUs, in St. Petersburg, RussiaNadia Abdala
Yale School of Public Health, New Haven, CT 06520 8034, USA
AIDS Behav 16:1597-604. 2012..Different paths leading to unprotected sex and multiple sexual partners call for different approaches to reduce sexual risk behaviors among this population...
- Comparing sexual risks and patterns of alcohol and drug use between injection drug users (IDUs) and non-IDUs who report sexual partnerships with IDUs in St. Petersburg, RussiaNadia Abdala
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
BMC Public Health 10:676. 2010..Petersburg, Russia and assessed associations between substance use patterns and sexual risks within and between those two groups...
- The relative role of perceived partner risks in promoting condom use in a three-city sample of high-risk, low-income womenAllison J Ober
Integrated Substance Abuse Programs, David Geffen School of Medicine, Semel Institute for Neuroscience and Behavior, University of California, Los Angeles, 90025, USA
AIDS Behav 15:1347-58. 2011..Awareness of a partner's risks may not be sufficient for increasing condom use. Contextual factors, sex with a main partner in particular, decrease condom use despite awareness of partner risk factors...
- Estimates of HIV incidence among drug users in St. Petersburg, Russia: continued growth of a rapidly expanding epidemicLinda M Niccolai
Yale School of Public Health, Center for Interdisciplinary Research on AIDS, Yale University, New Haven, CT 06520, USA
Eur J Public Health 21:613-9. 2011..To monitor the current epidemic situation, we sought to estimate recent HIV incidence among IDU in St Petersburg...
- Survival of hepatitis C virus in syringes: implication for transmission among injection drug usersElijah Paintsil
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Infect Dis 202:984-90. 2010..We hypothesized that the high prevalence of hepatitis C virus (HCV) among injection drug users might be due to prolonged virus survival in contaminated syringes...
- HIV disclosure, condom use, and awareness of HIV infection among HIV-positive, heterosexual drug injectors in St. Petersburg, Russian FederationLauretta E Grau
Division of Epidemiology of Microbial Diseases, Yale University School of Public Health, 60 College Street, P O Box 208034, New Haven, CT 06520 8034, USA
AIDS Behav 15:45-57. 2011..61, 95% CI 1.44-9.06) or HIV-seropositive (aOR 45.12, 95% CI 2.79-730.46). Scaling up HIV testing services and interventions that increase the likelihood of individuals receiving their test results is recommended...
- Relationship characteristics associated with anal sex among female drug usersMary Ellen Mackesy-Amiti
Community Outreach Intervention Projects, Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois, 1603 W Taylor Street, Chicago, IL 60612, USA
Sex Transm Dis 37:346-51. 2010..Anal sex is an important yet little studied HIV risk behavior for women...
- Estimation of the number of injection drug users in St. Petersburg, RussiaRobert Heimer
Yale School of Public Health, 60 College St, PO Box 208034, New Haven, CT, USA 06520 8034
Drug Alcohol Depend 109:79-83. 2010..Petersburg must be expanded access to HIV testing, prevention, and treatment that is targeted to IDUs...
- High HIV prevalence, suboptimal HIV testing, and low knowledge of HIV-positive serostatus among injection drug users in St. Petersburg, RussiaLinda M Niccolai
Department of Epidemiology and Public Health, Center for Interdisciplinary Research on AIDS, Yale School of Public Health, New Haven, CT 06520, USA
AIDS Behav 14:932-41. 2010..Adequate coverage of HIV testing has not been achieved, resulting in poor knowledge of positive serostatus. Efforts are needed to better understand motivating and deterring factors for HIV testing in this setting...
- Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIVMusie Ghebremichael
Department of Biostatistics, Harvard University and Dana Farber Cancer Center, Boston, MA, USA
AIDS Care 21:834-41. 2009..Moreover, depression is associated with HIV disease progression. Our findings have implications for the provision of alcohol use interventions and psychological resources to improve the health of women with HIV...
- Hepatitis C virus infection among drug injectors in St Petersburg, Russia: social and molecular epidemiology of an endemic infectionElijah Paintsil
Yale University School of Medicine, New Haven, CT 06520, USA
Addiction 104:1881-90. 2009..To understand the epidemiology and transmission patterns of hepatitis C virus (HCV), the predominant blood borne-pathogen infecting injection drug users (IDUs), in a part of the former Soviet Union...
- The potential for bridging of HIV transmission in the Russian Federation: sex risk behaviors and HIV prevalence among drug users (DUs) and their non-DU sex partnersLinda M Niccolai
Yale School of Public Health and Center for Interdisciplinary Research on AIDS, Yale University, 60 College Street, New Haven, CT 06520, USA
J Urban Health 86:131-43. 2009..The degree to which there will be further transmission from non-DU sex partners of DUs who exhibit high levels of sex risk behaviors to other non-DU sex partners deserves further study...
- Simultaneous recruitment of drug users and men who have sex with men in the United States and Russia using respondent-driven sampling: sampling methods and implicationsMartin Y Iguchi
RAND Corporation, 1776 Main Street, Santa Monica, CA 90407, USA
J Urban Health 86:5-31. 2009..The disadvantages were a recruitment bias by race/ethnicity and income status (at the US sites) and under-enrollment of MSM samples because of short recruitment chains (at the Russian site)...
- Alcohol abuse, sexual risk behaviors, and sexually transmitted infections in women in Moshi urban district, northern TanzaniaMusie Ghebremichael
Harvard University School of Public Health, Boston, Massachusetts, USA
Sex Transm Dis 36:102-7. 2009..To assess the covariates of alcohol abuse and the association between alcohol abuse, high-risk sexual behaviors and sexually transmitted infections (STIs)...