HIV PREVENTION TRIALS UNIT-THAILAND

Summary

Principal Investigator: David Celentano
Abstract: The Johns Hopkins University and its partners, Research Institute for Health Sciences [RIHES] and Faculty of Medicine, Chiang Mai University of Public Health Region 10; HIVNET 021 for participating medical centers; Northern Drug Dependence Treatment Center seek to be a Prevention Trial Network (PTN) Unit for Thailand. The purpose of our PTN Unit is to conduct state-of-the-art preventative interventions to slow the acquisition and transmission of HIV infection in this region. We propose to participate in HIV prevention trials in multi-site or single-site investigations in the following areas: (1) To continue our HIVNET sponsored investigation, "Hormonal Contraception and the Risk of HIV Acquisition (HIVNET 021)," which is a consortium of 7 clinical sites in Thailand and a Coordinating Center at RIHES. We are recruiting 2,600 women in 4 regions of Thailand over a 15-month period and following them at 3-month intervals for an average of 24 months with incident HIV and STDs as study endpoints. PTN support for the period June 2000 to July 2002 is requested in this application. (2) To conduct a Phase I safety and acceptability trial of an anorectal microbicidal for men who have sex with men (MSM) in Chiang Mai. Possible products include Nonoxynol-9, other spermicides, BufferGel or other promising compounds, along with promotion of the use of the female condom during anal intercourse. (3) To evaluate the following substance use related interventions: (a) a feasibility study of promoting drug treatment entry among HIV-1 infected drug users who have relapsed to drug use following inpatient drug detoxification at the NDTC in Mae Rim. (4) To conduct a Phase I trial for antenatal/intrapartum prevention of maternal to child transmission (MCT) of HIV-1 infection using ZT monotherapy vs. PETRA (AZT/ETC); PMPA, an investigational new drug that has been demonstrated in the laboratory to have intriguing anti-retroviral effects; a combination of proven anti-retrovirals (e.g. nevirapine and AZT) or other promising compounds, as recommended by the PTN's Perinatal Working Group. Under HIVNET, we received approval for the conduct of a Phase I safety and toxicity study of PMPA in 25 mother/infant pairs in Thailand; due to unexpected complications from the company, we have not yet been able to field this study but anticipate doing so this coming year. Our team has the capacity to rapidly respond to new opportunities in HIV prevention, as might occur within the PTN structure. Our partners have demonstrated over the past 9 years that we have the necessary infrastructure, trained manpower, scientific capability and expertise to both expand our efforts to meet the needs for large population efficacy trials, and to be able to recruit and retain very large, diverse cohorts which might be needed as trials are ready for Phase III implementation.
Funding Period: 2000-07-01 - 2008-06-30
more information: NIH RePORT

Top Publications

  1. pmc The dynamic relationship between social norms and behaviors: the results of an HIV prevention network intervention for injection drug users
    Carl Latkin
    Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Addiction 108:934-43. 2013
  2. pmc Behavioural strategies to reduce HIV transmission: how to make them work better
    Thomas J Coates
    UCLA Program in Global Health, Division of Infectious Diseases, University of California, Los Angeles, CA, USA
    Lancet 372:669-84. 2008
  3. pmc The efficacy of a network intervention to reduce HIV risk behaviors among drug users and risk partners in Chiang Mai, Thailand and Philadelphia, USA
    Carl A Latkin
    Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Soc Sci Med 68:740-8. 2009
  4. pmc Relationships between social norms, social network characteristics, and HIV risk behaviors in Thailand and the United States
    Carl Latkin
    Department of Health, John Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Health Psychol 28:323-9. 2009

Scientific Experts

Detail Information

Publications4

  1. pmc The dynamic relationship between social norms and behaviors: the results of an HIV prevention network intervention for injection drug users
    Carl Latkin
    Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Addiction 108:934-43. 2013
    ..This study examined changes in social norms and relationships between HIV injection risk behaviors and social norms among injection drug users (IDUs) involved in an experimental intervention...
  2. pmc Behavioural strategies to reduce HIV transmission: how to make them work better
    Thomas J Coates
    UCLA Program in Global Health, Division of Infectious Diseases, University of California, Los Angeles, CA, USA
    Lancet 372:669-84. 2008
    ..Fifth, we need to get the simple things right. The fundamentals of HIV prevention need to be agreed upon, funded, implemented, measured, and achieved. That, presently, is not the case...
  3. pmc The efficacy of a network intervention to reduce HIV risk behaviors among drug users and risk partners in Chiang Mai, Thailand and Philadelphia, USA
    Carl A Latkin
    Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Soc Sci Med 68:740-8. 2009
    ..The intervention did not result in overall reductions in self-reported sexual risk behaviors, and although reductions in injection risk behaviors were observed, the overall efficacy in reducing risk was not established...
  4. pmc Relationships between social norms, social network characteristics, and HIV risk behaviors in Thailand and the United States
    Carl Latkin
    Department of Health, John Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Health Psychol 28:323-9. 2009
    ..In this study, the authors examined whether the social norms of HIV risk behaviors are clustered within social networks and whether the norms of network members are linked to the risk behaviors of their social network members...