TRAINING PROGRAM IN HYPERTENSION

Summary

Principal Investigator: Gordon H Williams
Abstract: DESCRIPTION (provided by applicant): The Hypertension Training Program provides comprehensive, curriculum- and mentor- based research training in hypertension at the molecular, cellular, whole animal, translational, patient-oriented and population-oriented levels by continuing the process that began five years ago that integrated the resources of the Brigham and Women's Hospital (BWH) and the Morehouse School of Medicine (MSM) into a cohesive single, two site program. The training program is mature, being 35 years old, with nearly 2/3's of the preceptors serving longer than 5 years. Yet, also it is dynamic with 1/3 of the preceptors being new to the program. Administratively, the program is guided by three committees: Steering Committee (responsible for overall program structure and function);Mentoring Committee (responsible for the mentoring relationships);and Individual Research Committee (functions like a thesis committee). The Program is divided into five components. (1) The introductory course is a broad survey-type activity consisting of lectures and seminars that provide all trainees with broad exposure to endocrine, renal and cardiovascular physiology and pathophysiology, vascular biology, laboratory and patient-oriented research human subjects and animal care and ethics. (2) Mentor-guided research project(s) begin with trainees (with Mentoring Committee guidance) choosing one of the following broad training tracts: Patient/Population-Oriented Research;Human Genetics;or Bench Research, as well as (a) mentor(s). Trainees gain experience in diverse areas such as ethics of medical research, molecular biology, transgenic technology, signal transduction, receptor techniques, human and animal genetics, vascular biology, nutrition and detailed assessment of the factors regulating blood pressure at the cell, animal and human levels. (3) In their second year trainees are encouraged to participate in a degree program leading to a master in medical science or public health or a PhD. (4) On-going activities in this interdisciplinary, translational research program include the availability of co-mentors with specialized complementary expertise, an exchange program between MSM and BWH, a variety of lectures and seminars and rounds in which the trainee can give a presentation. (5) The program includes individual career guidance and mentoring with formal evaluations of the trainees, mentors and the program. Trainee selection criteria are: letters of recommendation, previous training experience, research interests, and the results of a personal interview. During the past 10 years, approximately 40% of entering trainees had an MD plus another degree or a PhD, with 10 MDs obtaining a second degree while in the training program. Under-representative minorities comprised 17% of the trainees during the past 10 years and 25% during the past 5 years. In the past 10 years, 90% of completers of the program have careers in research, teaching and/or administration in academia, government or industry. Funds are requested to continue to support eight post-doctoral trainees. (End of Abstract)
Funding Period: 1991-07-01 - 2018-07-31
more information: NIH RePORT

Top Publications

  1. pmc Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension
    Jonathan S Williams
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 25:812-7. 2012
  2. pmc Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance
    Patricia C Underwood
    Division of Endocrinology, Diabetes, and HTN, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 61:667-71. 2012
  3. pmc Correlation of cystatin-C with glomerular filtration rate by inulin clearance in pregnancy
    A R Saxena
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hypertens Pregnancy 31:22-30. 2012
  4. pmc Cardiovascular risk factors and menstrual cycle phase in pre-menopausal women
    A R Saxena
    Brigham and Women s Hospital, Boston, MA 02115, USA
    J Endocrinol Invest 35:715-9. 2012
  5. ncbi Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart
    Vincent Ricchiuti
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Endocrinol 211:47-54. 2011
  6. pmc Inflammation and hypertension: the interplay of interleukin-6, dietary sodium, and the renin-angiotensin system in humans
    Bindu Chamarthi
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s and Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 24:1143-8. 2011
  7. pmc Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension
    Luminita H Pojoga
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 96:E1288-92. 2011
  8. pmc The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Endocrinol (Oxf) 74:783-90. 2011
  9. pmc The association of the angiotensinogen gene with insulin sensitivity in humans: a tagging single nucleotide polymorphism and haplotype approach
    Patricia C Underwood
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 60:1150-7. 2011
  10. pmc Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation
    Rui Fang
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 39:222-33. 2010

Detail Information

Publications49

  1. pmc Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension
    Jonathan S Williams
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 25:812-7. 2012
    ..The aim of this study was to test the hypothesis that dietary salt influences the activity of a histone-modifying enzyme, lysine-specific demethylase 1 (LSD-1), which in turn is associated with salt-sensitivity of blood pressure (BP)...
  2. pmc Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance
    Patricia C Underwood
    Division of Endocrinology, Diabetes, and HTN, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 61:667-71. 2012
    ..05 × 10(-6)). This rare replication of a gene-environment interaction extends the generalizability of the results to hypertension while highlighting this polymorphism as a marker of IR in obese individuals...
  3. pmc Correlation of cystatin-C with glomerular filtration rate by inulin clearance in pregnancy
    A R Saxena
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hypertens Pregnancy 31:22-30. 2012
    ..To test utility of cystatin-C as a marker of glomerular filtration rate during pregnancy, we performed serial correlations with inulin clearance during pregnancy and postpartum...
  4. pmc Cardiovascular risk factors and menstrual cycle phase in pre-menopausal women
    A R Saxena
    Brigham and Women s Hospital, Boston, MA 02115, USA
    J Endocrinol Invest 35:715-9. 2012
    ..Exogenous estrogens have been shown to affect markers of cardiovascular risk in women...
  5. ncbi Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart
    Vincent Ricchiuti
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Endocrinol 211:47-54. 2011
    ..Dietary sodium restriction has beneficial effects on the cardiac expression of factors associated with CV injury. These changes may play a role in the cardioprotective effects of dietary sodium restriction...
  6. pmc Inflammation and hypertension: the interplay of interleukin-6, dietary sodium, and the renin-angiotensin system in humans
    Bindu Chamarthi
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s and Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 24:1143-8. 2011
    ..The aim of this study was to examine the relationship of IL-6 and renin-angiotensin system (RAS) activity in human hypertension...
  7. pmc Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension
    Luminita H Pojoga
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 96:E1288-92. 2011
    ..Caveolin-1 (CAV1), a gene previously associated with metabolic dysfunction in animal and cellular models, may be a marker for these conditions in humans...
  8. pmc The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Endocrinol (Oxf) 74:783-90. 2011
    ....
  9. pmc The association of the angiotensinogen gene with insulin sensitivity in humans: a tagging single nucleotide polymorphism and haplotype approach
    Patricia C Underwood
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 60:1150-7. 2011
    ..Thus, AGT gene variants, previously shown to be associated with AGT levels, are also associated with insulin sensitivity; suggesting a relationship between the AGT gene, AGT levels, and insulin sensitivity in humans...
  10. pmc Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation
    Rui Fang
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 39:222-33. 2010
    ..These data provide a possible molecular mechanism linking LSD2 to transcriptional regulation after initiation...
  11. pmc Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake
    A D Rao
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Hum Hypertens 27:176-80. 2013
    ..SGK1 genetic variants are associated with salt sensitivity of BP and PRA in human hypertension. Genotype status at these SGK1 variants may identify individuals prone to salt-sensitive hypertension...
  12. pmc Luteinizing hormone correlates with adrenal function in postmenopausal women
    Aditi R Saxena
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Menopause 19:1280-3. 2012
    ..Our objective was to explore the relationship of LH with adrenal function in postmenopausal women, as assessed by 24-hour urinary free cortisol (UFC) and aldosterone excretion rate (AER)...
  13. ncbi Long-term dietary sodium restriction increases adiponectin expression and ameliorates the proinflammatory adipokine profile in obesity
    R Baudrand
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago 8330074, Chile
    Nutr Metab Cardiovasc Dis 24:34-41. 2014
    ..We tested if long-term dietary sodium restriction modifies the expression of adiponectin and ameliorates the pro-inflammatory profile of obese, diabetic mice...
  14. pmc Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice
    Luminita H Pojoga
    Cardiovascular Endocrine Section, Endocrinology, Diabetes and Hypertension Division L H P, T M Y, A E G, G K A, G H W, and Division of Vascular and Endovascular Surgery L A O, O M R, R A K, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts
    J Pharmacol Exp Ther 348:260-70. 2014
    ....
  15. ncbi Aldosterone's mechanism of action: roles of lysine-specific demethylase 1, caveolin and striatin
    Rene Baudrand
    aDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School Boston, Massachusetts, USA bDepartment of Endocrinology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Curr Opin Nephrol Hypertens 23:32-7. 2014
    ..This review describes new mediators of aldosterone's mechanisms of action: lysine-specific demethylase 1 (LSD1), caveolin 1 (cav-1) and striatin...
  16. pmc Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone
    Jenifer M Brown
    Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, RFB, Boston, MA 02115
    Hypertension 63:273-80. 2014
    ..Future studies to evaluate the impact of RAAS inhibitors in treating PTH-mediated disorders are warranted. ..
  17. pmc Association of female reproductive factors with body composition: the Framingham Heart Study
    Subbulaxmi Trikudanathan
    Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 98:236-44. 2013
    ..The association of female reproductive factors with measures of regional body fat distribution has not been comprehensively studied...
  18. pmc Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter
    Robert M Carey
    Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1414, USA
    Hypertension 60:1359-66. 2012
    ..2 × 10(-5)]; rs1017783 [P=1.1 × 10(-4)]). In conclusion, SLC4A5 variants are strongly associated with salt sensitivity of blood pressure in 2 separate white populations...
  19. pmc Direct renin inhibition modulates insulin resistance in caveolin-1-deficient mice
    Somlak Chuengsamarn
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 62:275-81. 2013
    ..To test the hypothesis that aliskiren improves the metabolic phenotype in a genetic mouse model of the metabolic syndrome (the caveolin-1 (cav-1) knock out (KO) mouse)...
  20. pmc Nonmodulation as the mechanism for salt sensitivity of blood pressure in individuals with hypertension and type 2 diabetes mellitus
    Patricia C Underwood
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, RFB 386, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 97:3775-82. 2012
    ..However, studies supporting these assumptions may have been confounded by participant inclusion criteria, and study results may reflect target organ damage...
  21. pmc Different polymorphisms of the mineralocorticoid receptor gene are associated with either glucocorticoid or mineralocorticoid levels in hypertension
    Bei Sun
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 97:E1825-9. 2012
    ....
  22. ncbi Anemia in chronic kidney disease: new advances
    Tejas V Patel
    Renal Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Heart Fail Clin 6:347-57. 2010
    ..Lastly, while awaiting updated guidelines, the authors outline their recommendations on how to best manage patients who are anemic and have CKD...
  23. pmc Increased sensitivity to angiotensin II is present postpartum in women with a history of hypertensive pregnancy
    Aditi R Saxena
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Ave, RFB 2, Boston, MA 02115, USA
    Hypertension 55:1239-45. 2010
    ..Increased sensitivity to angiotensin II observed during pregnancy in women with hypertensive pregnancy is present postpartum; this feature may contribute to future cardiovascular risk in these women...
  24. pmc A mechanism for salt-sensitive hypertension: abnormal dietary sodium-mediated vascular response to angiotensin-II
    Bindu Chamarthi
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Hypertens 28:1020-6. 2010
    ..We tested the hypothesis that abnormalities in peripheral vascular responsiveness to angiotensin-II (ANGII) might also exist in salt-sensitive hypertension because of the interplay of the renin-angiotensin system and dietary sodium...
  25. ncbi Insulin induces renal vasodilation, increases plasma renin activity, and sensitizes the renal vasculature to angiotensin receptor blockade in healthy subjects
    Todd S Perlstein
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 18:944-51. 2007
    ..Further studies are warranted to address this balance in states of insulin resistance and the possible implications for the association of insulin resistance with risk for chronic kidney disease...
  26. ncbi Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension
    Bindu Chamarthi
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:1340-6. 2007
    ..Emerging evidence suggests a role for cortisol in essential hypertension, and preliminary reports indicate that urinary free cortisol (UFC) may be an intermediate phenotype...
  27. ncbi Ala92 type 2 deiodinase allele increases risk for the development of hypertension
    Olga Gumieniak
    Endocrinology, Diabetes, and Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 49:461-6. 2007
    ..These data support an important role for genetic variation in the hypothalamic-pituitary-thyroid pathway in influencing susceptibility to hypertension...
  28. ncbi Prorenin and angiotensin-dependent renal vasoconstriction in type 1 and type 2 diabetes
    Ana R Stankovic
    Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Am Soc Nephrol 17:3293-9. 2006
    ....
  29. ncbi Uric acid and the development of hypertension: the normative aging study
    Todd S Perlstein
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Hypertension 48:1031-6. 2006
    ..01 to 1.12; P=0.03). The baseline serum uric acid level is a durable marker of risk for the development of hypertension. The association is independent of elements of the metabolic syndrome, alcohol intake, and renal function...
  30. ncbi Estradiol increases proteinuria and angiotensin II type 1 receptor in kidneys of rats receiving L-NAME and angiotensin II
    E M Oestreicher
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Kidney Int 70:1759-68. 2006
    ..Thus, under conditions of low NO and high AngII, E2 exacerbated renal injury. E2-mediated increases in renal cortical AT(1)R expression may represent a novel mechanism for the adverse renovascular effects of estrogen...
  31. ncbi Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension
    Luminita Pojoga
    Brigham and Women s Hospital, Division of Endocrinology, Diabetes, and Hypertension, 221 Longwood Ave, Boston, MA 02115, USA
    Hypertension 48:892-900. 2006
    ..Importantly, this association could only be detected with an intermediate and not a distant phenotype...
  32. pmc Using regular expressions to abstract blood pressure and treatment intensification information from the text of physician notes
    Alexander Turchin
    Clinical Informatics Research and Development, Partners HealthCare System, 93 Worcester Street, Suite 201, Wellesley, MA 02481, USA
    J Am Med Inform Assoc 13:691-5. 2006
    ..8%, specificity of 95.0%, and precision of 85.9%. Regular expressions can be an effective method for focused information extraction tasks related to high-priority disease areas such as hypertension...
  33. ncbi Dietary sodium intake modulates myocardial relaxation responsiveness to angiotensin II
    Jonathan S Williams
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Transl Res 148:49-54. 2006
    ..Ang II may play a role in the interaction between dietary sodium and myocardial relaxation. Future research will investigate whether abnormalities in these mechanisms play a role in disorders of diastolic function...
  34. ncbi Hypertension, the Kuna, and the epidemiology of flavanols
    Marjorie L McCullough
    Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30309 4251, USA
    J Cardiovasc Pharmacol 47:S103-9; discussion 119-21. 2006
    ..Among dietary factors that varied among migrating Kuna, the notably higher intake of flavanol-rich cocoa is a potential candidate for further study...
  35. ncbi Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus
    Hylton V Joffe
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:2552-8. 2007
    ..Aldosterone causes cardiovascular injury and is not suppressed by chronic angiotensin converting enzyme (ACE) inhibitor therapy...
  36. ncbi Gender and the renal nitric oxide synthase system in healthy humans
    Sofia B Ahmed
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Clin J Am Soc Nephrol 2:926-31. 2007
    ..Animal models suggest that the renal vasculature of men may be significantly more dependent on nitric oxide than that of women...
  37. pmc Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II
    Luminita H Pojoga
    Brigham and Women s Hospital Harvard Medical School, Department of Endocrinology, Diabetes, and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocrinology 151:1236-46. 2010
    ..WT mice, consistent with decreased MR signaling in the cav-1 KO. Thus, we conclude that the L-NAME/AngII-induced biventricular damage is mediated by a mechanism partially dependent on cav-1 and signaling via MR/ALDO...
  38. pmc ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase
    Connie Ng Hess
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:32209-24. 2009
    ..These data suggest that the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS...
  39. pmc A comparison of prediction equations for estimating glomerular filtration rate in pregnancy
    Sofia B Ahmed
    Division of Nephrology, Department of Medicine, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    Hypertens Pregnancy 28:243-55. 2009
    ..To compare existing glomerular filtration rate (GFR) prediction equations with the gold standard, inulin clearance, in pregnancy...
  40. pmc Oral contraceptive progestins and angiotensin-dependent control of the renal circulation in humans
    M A Sarna
    Department of Medicine, University of Calgary, Alberta, Canada
    J Hum Hypertens 23:407-14. 2009
    ..002 between groups). Our results suggest that the OC progestin component is a significant influence on the degree of angiotensin-dependent control of the renal circulation, though these findings may not apply to women with diabetes...
  41. pmc Estradiol increases angiotensin II type 1 receptor in hearts of ovariectomized rats
    Vincent Ricchiuti
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Endocrinol 200:75-84. 2009
    ..In summary, E(2) treatment increased cardiac expression of AT(1)R as well as the expression of pro-inflammatory and prothrombotic factors...
  42. ncbi Angiotensinogen genotype predicts abnormal renal hemodynamics in young hypertensive patients
    Tejas V Patel
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Hypertens 26:1353-9. 2008
    ..This blunting has been associated with the angiotensinogen 235TT genotype. As several measures of renal function decline with age, we sought to determine the interaction of age and genotype on this intermediate phenotype...
  43. pmc Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines
    Christine Guo
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 117:2253-61. 2008
    ....
  44. pmc Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice
    Luminita H Pojoga
    Cardiovascular Endocrine Section, Endocrinology, Diabetes and Hypertension Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 294:H1258-65. 2008
    ..The data support the hypothesis that endothelial Cav-1, likely through an effect on eNOS activity, plays a prominent role in the regulation of vascular function during substantial changes in dietary sodium intake...
  45. pmc Cumulative community-level lead exposure and pulse pressure: the normative aging study
    Todd Perlstein
    Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Environ Health Perspect 115:1696-700. 2007
    ..Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote functional and structural vascular disease...
  46. ncbi Short- and long-term glycaemic control and the state of the renin system in type 1 diabetes mellitus
    Radomir D Stevanovic
    Department of Medicine, Saint Mary s Hospital, Waterbury, CT 06706, USA
    J Renin Angiotensin Aldosterone Syst 8:85-92. 2007
    ..72; p=0.008). Conversely, HbA1C correlated with none of the measures of renin system activation (r=0.05;p=0.7). In type 1 diabetic subjects, short-term hyperglycaemia, but not long-term glycaemic control, enhanced the RR to captopril...
  47. ncbi The influence of dietary sodium on blood pressure
    Norman K Hollenberg
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical Center, Boston, MA 02115, USA
    J Am Coll Nutr 25:240S-246S. 2006
    ..On the bright side, prognosis is improved substantially by the array of antihypertensive drugs available today...